Best TWAS P=2.78e-10 · Best GWAS P=2.71e-08 conditioned to 0.907
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellum | PRPS1P2 | 0.09 | 0.08 | enet | 16 | 0.04 | 2.8e-02 | 4.3 | -5.7 | 1.2e-08 | 0.85 | 0.05 | 0.77 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | GOLGA1 | 0.13 | 0.00 | enet | 8 | 0.06 | 3.8e-03 | -4.5 | -5.2 | 2.5e-07 | 0.79 | 0.16 | 0.62 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | PBX3 | 0.05 | 0.02 | enet | 7 | 0.00 | 1.4e-01 | 4.5 | -5.2 | 2.0e-07 | 0.16 | 0.08 | 0.78 | FALSE |
| 4 | GTEx | Nerve Tibial | PRPS1P2 | 0.11 | 0.11 | enet | 9 | 0.10 | 1.4e-07 | -5.5 | -5.6 | 1.8e-08 | 0.93 | 0.03 | 0.97 | FALSE |
| 5 | GTEx | Ovary | PRPS1P2 | 0.14 | 0.14 | lasso | 2 | 0.05 | 2.9e-02 | -4.5 | -5.1 | 2.8e-07 | 0.86 | 0.07 | 0.64 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | PPP6C | 0.08 | 0.06 | lasso | 4 | 0.05 | 7.8e-04 | -5.5 | 5.5 | 3.9e-08 | -0.99 | 0.02 | 0.95 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | RABEPK | 0.07 | 0.05 | lasso | 4 | 0.05 | 6.3e-05 | -5.5 | 5.4 | 5.2e-08 | -0.98 | 0.02 | 0.98 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | GAPVD1 | 0.04 | 0.01 | lasso | 4 | 0.01 | 3.8e-02 | -4.8 | 5.7 | 9.5e-09 | -0.87 | 0.07 | 0.89 | FALSE |
| 9 | GTEx | Spleen | PRPS1P2 | 0.18 | 0.02 | lasso | 4 | 0.04 | 3.9e-02 | -5.5 | -6.3 | 2.8e-10 | 0.91 | 0.05 | 0.56 | TRUE |
| 10 | GTEx | Thyroid | PRPS1P2 | 0.08 | 0.09 | enet | 18 | 0.07 | 4.0e-06 | -4.8 | -5.3 | 1.1e-07 | 0.87 | 0.17 | 0.83 | FALSE |
| 11 | NTR | Blood | MAPKAP1 | 0.03 | 0.01 | blup | 441 | 0.02 | 2.3e-07 | 4.8 | 5.2 | 2.3e-07 | 0.05 | 0.45 | 0.54 | TRUE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | PPP6C | 0.11 | 0.19 | lasso | 5 | 0.20 | 8.6e-26 | -5.4 | 5.4 | 5.1e-08 | -0.95 | 0.02 | 0.98 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | SCAI | 0.02 | 0.00 | bslmm | 316 | 0.00 | 3.3e-01 | 4.8 | 5.6 | 1.8e-08 | -0.40 | 0.04 | 0.28 | FALSE |
| 14 | YFS | Blood | RABEPK | 0.12 | 0.21 | bslmm | 317 | 0.22 | 2.4e-71 | -4.5 | 5.3 | 1.4e-07 | -0.83 | 0.66 | 0.33 | FALSE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PPP6C | 0.03 | 0.03 | lasso | 5 | 0.03 | 7.3e-07 | -5.4 | 5.3 | 8.8e-08 | -0.96 | 0.01 | 0.99 | FALSE |
| 16 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RABEPK | 0.02 | 0.02 | lasso | 2 | 0.02 | 1.4e-04 | -5.4 | 5.4 | 6.8e-08 | -0.99 | 0.00 | 0.99 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PPP6C | 0.05 | 0.06 | lasso | 3 | 0.05 | 1.1e-03 | -5.4 | 5.5 | 3.7e-08 | -0.98 | 0.01 | 0.90 | FALSE |
| 18 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | PPP6C | 0.17 | 0.06 | enet | 5 | 0.09 | 2.0e-04 | -5.4 | 5.4 | 6.7e-08 | -0.99 | 0.01 | 0.79 | FALSE |