Best TWAS P=3.65e-11 · Best GWAS P=6.11e-11 conditioned to 0.326
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | RPS6KL1 | 0.08 | 0.08 | enet | 11 | 0.07 | 1.5e-04 | 5.7 | 6.6 | 3.7e-11 | -0.94 | 0.02 | 0.98 | TRUE |
| 1 | CommonMind | Brain Pre-frontal Cortex | DLST | 0.09 | 0.11 | lasso | 2 | 0.11 | 4.0e-13 | -6.5 | 6.6 | 5.4e-11 | -0.98 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Testis | AREL1 | 0.20 | 0.14 | enet | 34 | 0.13 | 2.1e-06 | 5.9 | 6.3 | 2.9e-10 | -0.84 | 0.09 | 0.91 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RPS6KL1 | 0.03 | 0.02 | lasso | 3 | 0.02 | 8.5e-06 | 6.0 | 6.0 | 2.2e-09 | -0.84 | 0.07 | 0.93 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RPS6KL1 | 0.04 | 0.04 | lasso | 3 | 0.03 | 1.8e-04 | 6.0 | 5.7 | 9.7e-09 | -0.86 | 0.06 | 0.90 | FALSE |
| 4 | GTEx | Muscle Skeletal | DLST | 0.28 | 0.26 | enet | 23 | 0.26 | 2.1e-25 | -5.6 | -5.4 | 5.4e-08 | 0.61 | 0.65 | 0.35 | FALSE |
| 3 | GTEx | Adrenal Gland | RPS6KL1 | 0.21 | 0.13 | enet | 25 | 0.15 | 4.4e-06 | 5.1 | 5.4 | 8.0e-08 | -0.71 | 0.07 | 0.91 | FALSE |
| 9 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PROX2 | 0.07 | 0.01 | blup | 41 | 0.03 | 4.5e-03 | -6.5 | 5.2 | 1.6e-07 | -0.87 | 0.00 | 0.89 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | RPS6KL1 | 0.04 | 0.02 | lasso | 5 | 0.02 | 4.8e-04 | 4.5 | -5.2 | 1.9e-07 | 0.65 | 0.24 | 0.35 | FALSE |