TWAS hub - PROX2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Lung Adenocarcinoma	0.0597	0.0425	0.00036	0.004	0.026	0.024	NA	0.016	0.088	0.00049	0.00069	NA	0.005
2	TCGA	Soft Tissue Sarcoma	0.0670	0.0430	0.00220	0.013	0.033	0.019	NA	0.016	0.052	0.00450	0.02500	NA	0.035

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Taking other prescription medications	10.7	16.5	24.9	2.8	5.0
Number of treatments/medications taken	9.8	17.6	27.6	2.8	5.2
Medication for cholesterol	9.8	14.9	25.8	-2.0	-5.1
Fed-up feelings	9.2	16.8	20.0	4.5	3.7
Neuroticism	8.2	19.8	22.6	4.1	4.8
Neuroticism score	8.0	16.7	17.6	4.0	4.2
Suffer from ‘nerves’	7.5	11.8	13.3	3.6	3.2
Worry (Nagel 2018)	7.4	15.6	24.0	2.7	4.9
Seen doctor (GP) for nerves, anxiety, tension or depression	7.1	10.9	15.8	2.5	4.0
Mood swings	7.0	12.6	17.9	4.2	2.7
Neuroticism (Nagel 2018)	6.9	16.1	18.7	4.3	3.7
Depressed Affect (Nagel 2018)	6.5	13.7	21.1	4.6	2.5
Nervous feelings	6.5	12.0	21.2	1.7	4.6
Back pain experienced in last month	6.4	9.3	14.7	3.8	2.0
Ever unenthusiastic/disinterested for a whole week	6.3	7.7	9.3	2.5	3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	6.3	7.3	11.4	3.4	1.8
Medication: Bendroflumethiazide	5.9	8.9	17.8	-0.0	4.2
Medication: Lansoprazole	5.6	6.3	7.7	2.2	2.8
Chronic bronchitis/emphysema (mother)	5.3	6.2	12.4	3.5	-0.0
Worrier / anxious feelings	5.2	9.9	16.0	1.9	4.0
Tense / ‘highly strung’	5.2	8.6	17.0	0.5	4.1
Pain type(s) experienced in last month: Hip pain	5.2	6.5	11.5	3.4	1.3
Reaction Time	4.8	9.2	17.3	-4.2	1.1
Qualifications: nursing, teaching	4.8	7.5	14.9	0.1	-3.9
Illnesses of father: High blood pressure	4.8	5.9	10.8	-1.0	3.3
Medication: Atenolol	4.4	5.5	9.4	1.3	3.1
Supplements: Vitamin C	4.4	5.2	7.5	-1.7	-2.7
Number of self-reported non-cancer illnesses	4.4	7.6	9.6	2.4	3.1
Leg fat percentage (right)	4.3	15.4	28.0	1.7	5.3
Guilty feelings	4.3	6.5	7.6	2.8	2.3
Medication: Blood pressure	4.3	8.1	14.3	1.4	3.8
Wheeze or whistling in the chest in last year	4.0	7.2	11.0	1.9	3.3
Neck or shoulder pain in last month	4.0	5.6	7.2	2.0	2.7
Medication: Omeprazole	4.0	4.8	8.5	2.9	1.0
Lung FEV1/FVC ratio	3.9	19.7	25.3	-3.8	-5.0
Leg fat percentage (left)	3.9	14.2	25.4	1.7	5.0
Qualifications: A levels/AS levels or equivalent	3.7	8.2	8.7	-3.0	-2.8
Medication: Aspirin	3.7	4.9	9.2	0.8	3.0
Pain experienced in last month	3.7	6.2	6.3	-2.5	-2.5
Chronic bronchitis/emphysema (father)	3.6	4.2	5.3	2.3	-1.8
Medication for pain relief, constipation, heartburn	3.6	6.1	9.6	-1.6	-3.1
Other serious medical condition/disability diagnosed by doctor	3.5	4.6	5.7	1.8	2.4
Qualifications: None of the above	3.3	7.1	8.7	2.4	2.9
Seen a psychiatrist for nerves, anxiety, tension or depression	3.3	4.3	5.2	1.8	2.3
Chest pain or discomfort	3.3	4.8	8.2	-1.1	2.9
Type 2 Diabetes (T2D) (2012)	3.2	3.7	7.1	-2.7	0.5
Body fat percentage	3.2	12.6	24.7	-0.6	5.0
Eye problems/disorders: Cataract	3.2	3.7	6.7	-0.8	-2.6
Medication: Omeprazole (e.g. Zanprol)	3.2	3.9	7.5	2.7	0.6
Ever smoked	3.1	5.4	8.1	2.8	1.6
Knee pain experienced in last month	3.0	4.7	7.0	1.5	2.6
Age at First Birth	2.9	4.2	4.2	2.1	-2.0
Trunk fat percentage	2.9	11.6	21.3	-1.4	4.6
Schizophrenia vs Biploar Disorder	2.8	3.7	7.3	2.7	-0.0
Major Depression (MDD)	2.8	3.3	6.6	-0.3	2.6
Past tobacco smoking	2.8	5.1	5.6	-2.4	-2.1
Hair/balding pattern: Pattern 2	2.8	3.6	4.5	2.1	1.6
Long-standing illness, disability or infirmity	2.8	4.2	6.4	1.4	2.5
Medication: Aspirin	2.8	3.6	7.0	0.5	2.6
Ever had prostate specific antigen (PSA) test	2.8	3.2	4.3	-1.4	-2.1
Cholesterol lowering medication	2.8	4.1	5.8	2.4	1.6
Average weekly spirits intake	2.7	3.3	4.6	-2.1	-1.4
Medication: Levothyroxine sodium	2.7	4.6	7.3	1.4	2.7
Frequency of tiredness / lethargy in last 2 weeks	2.7	4.4	6.6	2.6	1.5
Hypothyroidism/myxoedema (self-reported)	2.7	5.2	6.0	2.1	2.4
Systolic Blood Pressure	2.6	13.0	22.6	-1.9	4.8
Average weekly fortified wine intake	2.6	3.0	5.9	-0.3	2.4
Headache pain in last month	2.6	4.6	5.0	2.0	2.2
Age at last live birth	2.6	3.7	7.4	0.2	-2.7
Medication: Gliclazide	2.6	3.0	4.6	-2.1	1.2
Sensitivity / hurt feelings	2.5	4.2	6.4	2.5	1.4
Arm fat percentage (right)	2.5	9.9	17.6	-1.4	4.2
Mean time to correctly identify matches	2.5	4.7	9.4	-3.1	-0.0
Smoking status: Previous	2.5	3.7	3.8	1.9	2.0
Fluid intelligence score	2.4	4.9	5.0	-2.2	-2.2
Happiness	2.4	2.9	5.4	2.3	0.7
Length of working week for main job	2.4	2.6	4.7	2.2	-0.8
Medication: Ventolin 100micrograms inhaler	2.4	3.0	5.8	2.4	-0.5
Loneliness, isolation	2.4	3.3	5.2	2.3	1.2
Irritability	2.4	4.1	6.9	1.1	2.6
Ulcerative Colitis (UC)	2.3	4.3	5.8	-1.7	2.4
Body Mass Index (BMI) (2010)	2.3	3.1	5.0	-1.1	2.2
Lung FVC	2.3	11.8	23.6	-0.2	4.9
Angina	2.3	3.0	6.0	0.1	2.4
Breast cancer (self-reported)	2.3	2.8	3.4	1.5	1.8
Number of operations (self-reported)	2.3	3.4	4.2	2.0	1.6
Qualifications: O levels/GCSEs or equivalent	2.2	3.5	4.9	-2.2	-1.4
Average weekly red wine intake	2.2	3.2	3.3	-1.8	-1.7
Handedness (chirality/laterality): Left-handed	2.2	2.6	4.2	-2.1	-1.0
Osteoarthritis (self-reported)	2.2	2.9	3.3	1.8	1.6
Verbal and Numeric Reasoning (VNR)	2.1	5.0	6.0	-2.0	-2.4
Hypothyroidism (self reported)	2.1	4.9	6.7	1.8	2.6
Systolic blood pressure, automated reading	2.1	6.1	11.2	-1.0	3.3
Impedance of leg (right)	2.1	10.1	13.6	2.6	3.7
Impedance of leg (left)	2.1	10.1	12.8	2.7	3.6
Had other major operations	2.1	2.6	4.7	2.2	0.7
Age at first live birth	2.1	3.7	7.5	0.1	-2.7
Health satisfaction	2.1	2.7	4.1	1.1	2.0
Shortness of breath walking on level ground	2.1	2.5	5.0	-0.2	2.2
Comparative height size at age 10	2.1	11.6	16.0	-2.7	-4.0
Overall health rating	2.1	4.5	6.7	1.5	2.6
Arm fat percentage (left)	2.1	8.3	14.6	-1.4	3.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.5	5.0	2.2	0.2
Irritable Bowel Disease (IBD)	2.0	4.8	5.5	-2.0	2.3
Bipolar Disorder (2011)	2.0	1.9	3.6	-0.5	-1.9
Medication: Co-codamol	2.0	2.4	3.2	1.8	1.2
Breastfed as a baby	2.0	2.5	3.3	-1.8	-1.3
Angina (self-reported)	2.0	2.6	4.8	-0.6	2.2
Family relationship satisfaction	2.0	2.4	4.5	0.6	2.1
Medication for hormone replacement therapy	1.9	2.1	3.9	0.6	2.0
Ever highly irritable/argumentative for 2 days	1.9	2.3	2.9	1.3	1.7
Exposure to tobacco smoke outside home	1.9	2.5	3.7	1.1	1.9
Qualifications: College or University degree	1.9	6.0	9.8	-1.5	-3.1
Migraine (self-reported)	1.9	2.3	3.1	1.8	1.3
Financial situation satisfaction	1.9	2.4	4.4	2.1	-0.6
Commuting to job workplace: Public transport	1.9	2.3	4.4	-0.3	-2.1
Alzheimer’s Disease (in mother)	1.8	2.1	2.6	-1.3	-1.6
Blood Platelet Count	1.8	20.3	22.5	-4.7	-4.3
Chronotype (morning person)	1.8	4.1	6.0	1.5	-2.4
Hearing difficulty/problems: Yes	1.8	2.8	5.4	-0.3	2.3
Medication: Metformin	1.8	2.5	2.7	-1.6	1.5
Medication: Simvastatin	1.8	2.7	3.2	1.5	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.2	4.2	0.5	2.0
Lung cancer (father)	1.7	2.0	3.7	1.9	-0.6
Hypertension (Self-reported)	1.7	4.7	9.4	0.1	3.1
Diastolic blood pressure, automated reading	1.7	5.2	10.0	-0.6	3.2
Supplements: Calcium	1.7	1.9	3.5	0.5	1.9
Heart disease (siblings)	1.7	2.1	2.2	-1.4	1.5
HDL Cholesterol	1.6	2.7	5.3	-0.2	-2.3
Ever used hormone-replacement therapy (HRT)	1.6	2.1	2.5	1.6	1.3
High blood pressure (mother)	1.6	2.2	4.1	-0.6	2.0
Hearing difficulty/problems with background noise	1.6	2.6	5.1	-0.3	2.3
Asthma	1.6	3.2	4.9	1.2	2.2
Depression (self-reported)	1.6	1.9	2.5	1.6	1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	2.0	1.4	1.3
Medication: Blood pressure	1.6	2.8	4.1	1.3	2.0
Number of full sisters	1.6	2.0	2.5	1.6	-1.2
Coronary Artery Disease (CAD)	1.5	1.8	2.8	1.7	0.9
Lupus	1.5	2.3	3.9	2.0	0.8
Triglycerides	1.5	2.4	3.4	1.2	1.8
Cardiovascular Disease	1.5	4.9	9.5	0.5	3.1
Noisy workplace	1.5	1.9	2.7	1.6	1.0
Trunk predicted mass	1.5	8.4	15.8	1.0	-4.0
Asthma (self-reported)	1.5	3.0	4.2	1.3	2.1
Neuroticism (2016)	1.4	2.0	3.1	1.8	1.0
Waist Hip Ratio (WHR)	1.4	6.5	12.5	-0.7	3.5
Smoking Status	1.4	3.4	5.0	2.2	1.4
Allergy or Eczema	1.4	3.6	6.6	-2.6	-0.8
Frequency of depressed mood in last 2 weeks	1.4	1.9	2.3	1.2	1.5
Age when periods started (menarche)	1.4	3.3	5.6	2.4	-1.0
Trunk fat-free mass	1.4	8.2	15.4	1.0	-3.9
Hair/balding pattern: Pattern 3	1.4	2.0	4.0	-0.2	-2.0
Gout (self-reported)	1.4	1.9	3.6	1.9	-0.3
Eye problems/disorders: None of the above	1.4	1.6	2.8	1.7	0.7
Diabetes diagnosed by doctor	1.4	2.2	4.2	-2.1	0.5
Miserableness	1.4	2.5	4.3	2.1	0.8
Ever taken oral contraceptive pill	1.4	1.6	2.1	1.5	1.0
Vascular/heart problems diagnosed by doctor	1.4	3.7	7.4	-0.2	-2.7
Depression (Nagel 2018)	1.3	2.0	3.5	0.7	1.9
Height	1.3	25.8	50.4	1.1	-7.1
Pulse rate	1.3	2.2	4.2	0.2	-2.1
Medication: Amlodipine	1.3	1.8	2.5	1.1	1.6
Birth weight	1.3	2.9	4.7	2.2	-1.0
Leg fat mass (right)	1.3	4.9	9.5	0.6	3.1
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.2	1.5	-1.0
Leg fat-free mass (right)	1.3	7.0	10.2	-1.9	-3.2
Leg predicted mass (right)	1.3	7.1	10.2	-2.0	-3.2
Fasting Glucose	1.2	1.5	2.1	-1.4	-0.9
High blood pressure	1.2	3.4	6.8	0.0	2.6
Trunk fat mass	1.2	5.0	9.3	-0.9	3.0
Mouth/teeth dental problems	1.2	1.8	2.5	-1.1	-1.6
Father’s age at death	1.2	1.6	2.3	-0.9	-1.5
Standing height	1.2	12.1	23.9	-0.5	-4.9
Commuting to job workplace: Walk	1.2	1.3	2.6	-1.6	0.1
Wears glasses or contact lenses	1.2	1.4	2.7	1.6	-0.0
High cholesterol (Self-reported)	1.2	2.1	3.1	1.8	1.0
Ever had hysterectomy (womb removed)	1.1	1.2	2.4	1.6	0.2
Severe depression (siblings)	1.1	1.3	2.0	0.7	1.4
Townsend deprivation index at recruitment	1.1	1.6	2.1	1.5	1.0
Hayfever, allergic rhinitis or eczema	1.1	2.3	4.5	-2.1	-0.2
Alcohol usually taken with meals	1.1	1.7	3.4	-1.8	-0.3
Impedance of arm (right)	1.1	5.1	5.2	-2.3	2.3
Medication: Paracetamol	1.1	1.8	2.5	1.0	1.6
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.6	-0.2	-1.9
Emphysema/chronic bronchitis	1.1	1.2	1.9	0.7	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	1.5	-1.0	1.2
Whole body fat mass	1.1	4.5	8.7	-0.5	3.0
Whole body water mass	1.1	6.1	12.1	0.1	-3.5
Medication: Paracetamol	1.1	1.7	2.3	1.0	1.5
Pack years of smoking	1.1	1.6	2.0	1.1	-1.4
Ulcerative Colitis	1.0	1.5	1.7	-1.3	1.1
Blood Eosinophil Count	1.0	7.6	15.1	-0.4	-3.9
Pack years adult smoking proportion	1.0	1.5	1.6	1.3	-1.2
Leg fat-free mass (left)	1.0	5.5	6.9	-2.0	-2.6
Leg predicted mass (left)	1.0	5.5	7.1	-2.0	-2.7
Waist circumference	1.0	3.5	6.9	-0.2	2.6
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	2.9	0.4	1.7
Financial difficulties in last 2 years	1.0	1.3	2.2	0.6	-1.5
Illnesses of siblings	1.0	1.4	2.8	-0.0	-1.7
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.3	1.5	0.2
Medication: Allopurinol	1.0	1.3	1.7	1.3	-0.9
Medication: Seretide 50 evohaler	1.0	1.2	1.7	1.3	-0.8
Heart disease (mother)	1.0	1.2	1.6	1.3	0.9
Whole body fat-free mass	1.0	6.0	12.0	0.0	-3.5
Basal cell carcinoma (self-reported)	1.0	1.2	1.2	-1.1	-1.1
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.1	0.8	-1.4
Leg fat mass (left)	1.0	4.0	7.5	0.7	2.7
Blood White Count	0.9	6.6	7.9	-2.8	-2.3
BMI	0.9	5.4	10.6	-0.4	3.3
Respiratory disease	0.9	2.0	3.6	0.6	1.9
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.2	-1.8	-0.4
Diabetes (father)	0.9	1.1	2.2	0.3	1.5
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.7	-1.3	0.5
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	1.9	0.5	-1.4
Body mass index (BMI)	0.9	3.7	7.4	0.2	2.7
Number of incorrect matches in round	0.9	1.5	2.7	0.5	1.6
Illnesses of mother	0.9	1.1	1.6	-1.2	-0.9
Impedance of arm (left)	0.9	4.1	5.8	-2.4	1.5
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.3	0.1	1.5
Arm fat-free mass (right)	0.9	4.6	7.8	1.2	-2.8
Comparative body size at age 10	0.9	2.4	4.8	-2.2	0.1
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	1.4	-1.2	-1.2
Eye problems/disorders: Glaucoma	0.9	1.0	1.4	-1.2	0.8
Medication: Lisinopril	0.9	1.1	2.0	0.4	1.4
Ever depressed for a whole week	0.9	1.1	2.1	1.5	0.4
Myopia	0.9	1.2	1.8	1.3	0.8
Impedance of whole body	0.9	4.4	8.8	-0.3	3.0
Heel T-Score	0.8	6.3	11.9	3.5	0.8
Current tobacco smoking	0.8	1.3	1.9	1.4	0.8
Medication: Ramipril	0.8	1.0	2.0	-0.2	1.4
Medication: Cholesterol lowering	0.8	1.2	2.0	-0.7	1.4
Arm fat mass (right)	0.8	3.2	6.2	-0.4	2.5
Hair/balding pattern: Pattern 4	0.8	2.0	2.4	-1.2	-1.6
Glaucoma (self-reported)	0.8	1.0	1.1	-0.9	1.1
Arm predicted mass (right)	0.8	4.2	6.9	1.2	-2.6
Ever had bowel cancer screening	0.8	0.9	1.7	1.3	0.2
Intelligence (Savage-Jansen 2018)	0.7	2.3	3.5	-1.0	-1.9
Alzheimer’s Disease (in father)	0.7	0.7	1.5	-1.2	0.1
Crohns Disease (2017)	0.7	1.6	2.0	-1.0	1.4
Schizophrenia (2014)	0.7	1.5	2.9	1.7	-0.3
Maternal smoking around birth	0.7	1.0	1.8	1.3	0.4
Blood clot in the leg (DVT)	0.7	0.9	1.3	0.7	-1.2
High blood pressure (siblings)	0.7	1.0	2.0	1.4	0.2
Worry too long after embarrassment	0.7	1.2	2.3	1.5	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.6	-0.4	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	1.9	-1.0	1.4
Medication: Atorvastatin	0.7	0.9	1.8	0.1	1.4
Ovarian Cancer	0.6	0.8	1.5	-0.3	1.2
HbA1C	0.6	0.7	0.8	-0.7	-0.9
Vitamin and mineral supplements	0.6	0.8	1.2	1.1	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.6	1.6	0.2
Stomach or abdominal pain in last month	0.6	0.8	1.6	1.2	0.1
Diabetes (self-reported)	0.6	0.9	1.7	-1.3	0.5
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.6	-0.2	1.3
Alcohol intake frequency.	0.6	1.4	1.6	-1.3	1.1
Illnesses of father: Heart disease	0.6	0.9	1.8	-0.0	1.3
Illnesses of siblings: Diabetes	0.6	0.8	1.1	0.7	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.2	-1.1	0.2
Illnesses of father: None of the above (group 1)	0.6	0.7	1.1	0.6	-1.0
Smoking status: Current	0.6	0.9	1.0	1.0	0.8
Arm fat mass (left)	0.6	2.7	4.9	-0.6	2.2
Basal metabolic rate	0.6	3.1	6.1	-0.2	-2.5
Arm fat-free mass (left)	0.6	2.8	4.2	1.2	-2.1
Arm predicted mass (left)	0.6	2.9	4.0	1.3	-2.0
Prostate Cancer	0.5	0.7	1.0	1.0	0.5
Rheumatoid Arthritis	0.5	0.7	1.1	1.0	-0.6
Supplements: Glucosamine	0.5	0.6	1.1	-1.1	0.2
Sitting height	0.5	3.8	5.2	-1.5	-2.3
Forced expiratory volume in 1-second (FEV1)	0.5	1.5	3.0	-1.7	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	0.9	-0.9	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.3	-0.1	1.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.7	-0.8	0.7
Average weekly beer plus cider intake	0.5	0.7	1.0	0.6	1.0
Risk taking	0.5	0.7	1.5	0.1	-1.2
Mean Putamen Volume	0.4	0.5	0.9	0.0	1.0
Tanning	0.4	4.5	9.1	-0.0	-3.0
Supplements: Zinc	0.4	0.5	0.9	-1.0	0.2
Serious illness, injury or assault to yourself	0.4	0.5	1.1	0.1	1.0
Had menopause	0.4	0.6	0.9	1.0	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.8	1.4	0.4
Heart attack	0.4	0.5	0.7	0.8	0.6
Bipolar Disorder (2018)	0.3	0.4	0.8	-0.9	-0.1
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	0.0	-0.9
Hand grip strength (left)	0.3	0.8	1.3	0.6	1.1
Qualifications: CSEs or equivalent	0.3	0.4	0.7	-0.2	0.8
Allergy	0.3	0.7	1.4	1.2	-0.2
Time employed in main current job	0.3	0.4	0.8	-0.9	0.0
Mouth/teeth dental problems: Dentures	0.3	0.5	0.6	0.8	0.6
Number of children fathered	0.3	0.3	0.4	-0.6	0.5
Pulse wave peak to peak time	0.3	0.3	0.6	0.8	0.1
Medication: Ibuprofen	0.3	0.3	0.6	-0.3	0.7
Breast Cancer	0.2	0.6	0.9	-0.9	-0.6
Crohns Disease (2012)	0.2	0.3	0.6	-0.1	-0.7
Primary Biliary Cirrhosis	0.2	0.3	0.5	0.7	0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.2	-0.4	0.5
Diabetes (mother)	0.2	0.3	0.3	0.5	-0.5
Pain all over the body in last month	0.2	0.2	0.2	0.5	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.4	-1.2	0.0
Pulse wave Arterial Stiffness index	0.2	0.3	0.4	-0.7	-0.3
Birth weight of first child	0.2	0.4	0.7	-0.8	-0.1
Loud music exposure frequency	0.2	0.3	0.3	-0.4	-0.6
Number of full brothers	0.2	0.3	0.5	0.7	0.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	-0.0	0.7
Mineral and other dietary supplements	0.2	0.2	0.5	0.7	0.1
Osteoporosis (self-reported)	0.2	0.2	0.3	0.6	0.3
Average weekly champagne plus white wine intake	0.2	0.3	0.6	0.1	-0.8
Hearing aid user	0.2	0.2	0.3	-0.6	0.3
Fractured/broken bones in last 5 years	0.2	0.2	0.3	-0.4	0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.4	0.6	0.4
Schizophrenia (2018)	0.1	0.1	0.2	0.4	-0.2
LDL Cholesterol	0.1	0.1	0.1	0.3	-0.3
Hair Pigment	0.1	2.5	4.3	0.8	2.1
Relative age of first facial hair	0.1	0.2	0.3	0.6	-0.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.3	0.5	0.1
Multivitamins +/- minerals	0.1	0.1	0.2	-0.4	0.2
Forced vital capacity (FVC)	0.1	0.5	0.6	-0.8	0.6
Hip circumference	0.1	0.3	0.5	-0.1	0.7
Alcohol intake versus 10 years previously	0.1	0.2	0.4	0.6	0.3
Falls in the last year	0.1	0.1	0.3	0.5	-0.1
Number of live births	0.1	0.1	0.2	-0.4	-0.2
Prospective memory result	0.1	0.1	0.3	0.5	-0.1
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.2	0.4
Forced vital capacity (FVC), Best measure	0.1	0.3	0.6	-0.3	0.8
Had major operations	0.1	0.1	0.1	-0.3	-0.3
Leg pain on walking	0.1	0.1	0.2	-0.0	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.2	0.4	0.4
Friendships satisfaction	0.1	0.1	0.1	0.4	-0.3
Mother’s age at death	0.1	0.1	0.2	0.0	-0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	-0.3	-0.5
Alcohol drinker status: Never	0.1	0.1	0.1	-0.3	0.1
Age started oral contraceptive pill	0.1	0.1	0.1	0.3	-0.2
Unable to work because of sickness or disability	0.1	0.1	0.1	0.3	-0.2
Commuting to job workplace: Cycle	0.1	0.1	0.2	-0.2	-0.4
Alcohol drinker status: Previous	0.1	0.1	0.2	0.1	0.5
Bipolar Disorder or Schizophrenia	0.0	0.1	0.1	-0.3	-0.3
Blood Red Count	0.0	0.2	0.3	0.5	0.5
Hand grip strength (right)	0.0	0.1	0.1	0.3	0.2
Relative age voice broke	0.0	0.0	0.1	0.1	-0.2
Weight	0.0	0.2	0.2	-0.3	0.5
Peak expiratory flow (PEF)	0.0	0.1	0.1	0.1	0.3
Pulse wave reflection index	0.0	0.0	0.0	0.0	-0.2
Pulse rate, automated reading	0.0	0.1	0.2	-0.3	0.4

Hub : Genes

PROX2

Models

Trait associations