[Hub]/) : Traits : Alcohol intake frequency. : ← →

chr11:46,622,392-48,485,877

Best TWAS P=3.05e-13 · Best GWAS P=1.79e-12 conditioned to 0.356

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Brain Cortex	C1QTNF4	0.26	0.04	lasso	8	0.02	1.2e-01	-6.9	-7.3	3.1e-13	0.92	0.04	0.31	TRUE
41	The Cancer Genome Atlas	Colon Adenocarcinoma	NUP160	0.05	0.05	blup	44	0.05	7.7e-04	-7.0	7.3	3.1e-13	-0.98	0.02	0.83	FALSE
25	GTEx	Spleen	C1QTNF4	0.31	0.28	enet	29	0.34	1.8e-09	6.2	-7.2	5.7e-13	0.86	0.17	0.82	FALSE
9	GTEx	Cells Transformed fibroblasts	FNBP4	0.11	0.05	lasso	8	0.08	1.6e-06	-7.0	7.1	1.5e-12	-0.93	0.03	0.97	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	FNBP4	0.04	0.04	lasso	3	0.04	8.2e-06	-7.0	7.0	2.1e-12	-0.95	0.04	0.96	FALSE
27	GTEx	Testis	C1QTNF4	0.14	0.12	lasso	4	0.11	1.6e-05	-7.0	-6.9	6.1e-12	0.97	0.03	0.96	FALSE
24	GTEx	Skin Sun Exposed Lower leg	C1QTNF4	0.25	0.22	lasso	12	0.23	4.2e-19	6.6	-6.8	9.0e-12	0.83	0.32	0.68	FALSE
15	GTEx	Heart Atrial Appendage	C1QTNF4	0.26	0.14	lasso	9	0.17	3.9e-08	6.6	-6.8	1.1e-11	0.76	0.48	0.51	FALSE
52	The Cancer Genome Atlas	Lung Adenocarcinoma	C1QTNF4	0.03	0.02	blup	15	0.02	1.3e-03	6.6	-6.7	2.2e-11	0.69	0.02	0.87	FALSE
20	GTEx	Muscle Skeletal	C1QTNF4	0.09	0.14	lasso	3	0.13	9.9e-13	6.6	-6.7	2.7e-11	0.73	0.28	0.72	FALSE
3	GTEx	Adipose Subcutaneous	C1QTNF4	0.16	0.22	lasso	4	0.22	2.5e-18	6.7	-6.7	2.9e-11	0.72	0.25	0.75	FALSE
10	GTEx	Cells Transformed fibroblasts	NDUFS3	0.08	0.01	lasso	2	0.01	3.3e-02	6.7	-6.6	3.3e-11	0.76	0.09	0.60	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUP160	0.03	0.02	enet	7	0.02	6.3e-03	5.9	6.6	3.8e-11	-0.74	0.06	0.37	FALSE
14	GTEx	Esophagus Muscularis	C1QTNF4	0.10	0.05	enet	23	0.06	1.4e-04	6.7	-6.6	3.9e-11	0.82	0.15	0.83	FALSE
4	GTEx	Artery Aorta	C1QTNF4	0.09	0.10	lasso	1	0.08	3.2e-05	6.6	-6.6	4.7e-11	0.73	0.26	0.58	FALSE
12	GTEx	Esophagus Mucosa	C1QTNF4	0.10	0.11	lasso	1	0.10	5.0e-07	6.6	-6.6	4.7e-11	0.73	0.21	0.78	FALSE
16	GTEx	Heart Left Ventricle	C1QTNF4	0.10	0.11	lasso	1	0.09	1.1e-05	6.6	-6.6	4.7e-11	0.73	0.18	0.48	FALSE
39	The Cancer Genome Atlas	Colon Adenocarcinoma	C1QTNF4	0.12	0.12	lasso	1	0.12	1.6e-07	6.6	-6.6	4.7e-11	0.73	0.01	0.99	FALSE
43	The Cancer Genome Atlas	Esophageal Carcinoma	C1QTNF4	0.39	0.33	blup	15	0.35	6.1e-12	6.6	-6.6	5.0e-11	0.73	0.02	0.98	FALSE
11	GTEx	Colon Transverse	C1QTNF4	0.07	0.02	lasso	6	0.03	2.0e-02	6.7	-6.5	9.7e-11	0.71	0.21	0.34	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FAM180B	0.07	0.08	lasso	3	0.08	9.1e-10	6.6	6.4	1.4e-10	-0.69	0.69	0.31	FALSE
18	GTEx	Liver	C1QTNF4	0.25	0.14	enet	16	0.20	2.3e-06	6.6	-6.4	1.4e-10	0.71	0.26	0.55	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1QTNF4	0.12	0.14	enet	4	0.16	6.5e-18	5.9	-6.3	2.2e-10	0.69	0.14	0.86	FALSE
37	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1QTNF4	0.06	0.07	lasso	2	0.06	4.9e-06	5.9	-6.3	3.6e-10	0.68	0.04	0.96	FALSE
19	GTEx	Lung	C1QTNF4	0.18	0.15	lasso	6	0.13	3.2e-10	5.7	-6.2	6.1e-10	0.66	0.90	0.10	FALSE
54	The Cancer Genome Atlas	Stomach Adenocarcinoma	C1QTNF4	0.06	0.04	lasso	4	0.03	4.3e-03	5.9	-6.2	6.5e-10	0.66	0.02	0.68	FALSE
28	GTEx	Whole Blood	C1QTNF4	0.09	0.05	lasso	3	0.03	1.4e-03	6.2	-6.2	7.6e-10	0.65	0.54	0.16	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	MTCH2	0.35	0.40	enet	9	0.40	4.7e-56	5.9	6.1	8.5e-10	-0.66	0.97	0.03	FALSE
34	YFS	Blood	FNBP4	0.02	0.01	bslmm	301	0.01	8.9e-05	-5.5	6.1	1.2e-09	-0.64	0.17	0.74	FALSE
13	GTEx	Esophagus Muscularis	MTCH2	0.09	0.04	lasso	6	0.02	1.8e-02	6.0	6.0	2.2e-09	-0.68	0.42	0.26	FALSE
30	NTR	Blood	MTCH2	0.02	0.04	lasso	1	0.04	1.3e-11	6.0	-6.0	2.3e-09	0.64	0.94	0.06	FALSE
46	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C1QTNF4	0.13	0.16	lasso	1	0.16	3.1e-09	6.0	-6.0	2.3e-09	0.64	0.20	0.80	FALSE
36	YFS	Blood	PTPMT1	0.03	0.01	lasso	5	0.01	3.2e-04	-6.9	-6.0	2.5e-09	0.81	0.06	0.92	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	C1QTNF4	0.32	0.18	enet	33	0.20	5.2e-11	6.6	-5.9	3.1e-09	0.71	0.27	0.73	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1QTNF4	0.06	0.08	lasso	3	0.08	7.5e-09	5.9	-5.9	3.5e-09	0.64	0.14	0.86	FALSE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTCH2	0.11	0.11	lasso	2	0.10	6.4e-12	5.9	5.9	3.9e-09	-0.64	0.80	0.20	FALSE
50	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C1QTNF4	0.19	0.19	lasso	3	0.19	3.2e-09	5.9	-5.9	3.9e-09	0.64	0.21	0.79	FALSE
8	GTEx	Breast Mammary Tissue (Female)	MADD	0.13	0.04	lasso	3	0.05	1.3e-02	5.6	5.9	4.6e-09	-0.60	0.07	0.07	FALSE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYBPC3	0.02	0.01	blup	43	0.01	3.4e-03	5.7	-5.8	6.0e-09	0.64	0.01	0.97	FALSE
21	GTEx	Nerve Tibial	C1QTNF4	0.20	0.23	enet	12	0.23	1.7e-16	6.6	-5.8	6.7e-09	0.61	0.24	0.76	FALSE
26	GTEx	Testis	MTCH2	0.17	0.16	lasso	3	0.16	1.0e-07	5.7	5.7	1.2e-08	-0.59	0.97	0.03	FALSE
29	METSIM	Adipose	C1QTNF4	0.24	0.31	lasso	7	0.31	1.2e-46	5.9	-5.7	1.2e-08	0.60	0.97	0.03	FALSE
47	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSMC3	0.07	0.07	enet	7	0.06	1.4e-04	5.6	5.7	1.2e-08	-0.59	0.01	0.98	FALSE
42	The Cancer Genome Atlas	Colon Adenocarcinoma	PSMC3	0.09	0.05	blup	39	0.05	1.0e-03	-3.7	5.6	1.8e-08	-0.79	0.02	0.82	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MTCH2	0.03	0.00	bslmm	299	0.00	1.1e-01	-1.2	5.6	2.6e-08	-0.71	0.07	0.49	FALSE
7	GTEx	Breast Mammary Tissue	C1QTNF4	0.10	0.06	lasso	2	0.03	8.5e-03	5.7	-5.5	3.1e-08	0.58	0.28	0.14	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	PSMC3	0.10	0.05	blup	39	0.08	3.7e-09	5.7	5.5	3.8e-08	-0.57	0.02	0.98	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	C1QTNF4	0.04	0.01	blup	15	0.03	7.9e-04	6.6	-5.5	4.6e-08	0.46	0.01	0.74	FALSE
22	GTEx	Pituitary	MADD	0.42	0.32	lasso	6	0.39	8.9e-11	-2.9	5.4	6.7e-08	-0.66	0.44	0.35	FALSE
40	The Cancer Genome Atlas	Colon Adenocarcinoma	KBTBD4	0.14	0.01	blup	13	0.02	1.6e-02	-6.8	5.4	7.7e-08	-0.61	0.00	0.52	FALSE
51	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSMC3	0.09	0.07	blup	39	0.06	8.7e-04	5.7	5.4	8.7e-08	-0.46	0.01	0.98	FALSE
5	GTEx	Brain Cortex	MTCH2	0.21	0.19	lasso	6	0.16	4.0e-05	6.2	5.3	1.5e-07	-0.49	0.40	0.08	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	C1QTNF4	0.05	0.06	blup	281	0.06	1.7e-08	5.7	-5.2	2.2e-07	0.51	0.90	0.10	FALSE
17	GTEx	Liver	PSMC3	0.15	0.09	lasso	4	0.07	5.9e-03	4.2	5.1	3.0e-07	-0.42	0.08	0.17	FALSE
35	YFS	Blood	PSMC3	0.02	0.01	blup	289	0.01	2.8e-05	6.7	5.1	3.1e-07	-0.62	0.33	0.51	FALSE