Hub : Genes

PTPMT1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Skin Sun Exposed Lower leg 0.1280 0.0600 0.00032 0.012 NA 0.026 NA 0.010 0.03400 NA 0.00300 NA 0.04300
2 ROSMAP Brain Pre-frontal Cortex 0.0329 0.0157 0.00049 0.020 0.024 0.013 0.023 0.018 0.00120 0.00038 0.00720 0.00054 0.00170
3 YFS Blood 0.0276 0.0164 0.00024 0.007 0.008 0.007 0.009 0.009 0.00190 0.00082 0.00150 0.00035 0.00032
4 TCGA Kidney Renal Clear Cell Carcinoma 0.0655 0.0360 0.00490 0.028 0.012 0.025 NA 0.024 0.00033 0.01500 0.00068 NA 0.00100

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.0 1.6 2.9 1.0 1.7 0.6 1.5
Bipolar Disorder or Schizophrenia 0.8 1.9 3.6 0.7 1.9 0.2 1.9
Depressed Affect (Nagel 2018) 3.8 7.9 15.1 1.7 -0.6 3.9 3.7
Depression (Nagel 2018) 1.5 2.2 3.5 1.1 1.0 1.7 1.9
Intelligence (Savage-Jansen 2018) 2.8 8.6 14.5 3.0 3.8 3.1 1.2
Neuroticism (Nagel 2018) 3.6 8.3 18.8 0.5 -0.1 4.3 3.8
Schizophrenia (2018) 0.3 0.7 1.5 0.3 1.0 -0.2 1.2
Schizophrenia vs Biploar Disorder 0.4 0.5 0.8 -0.3 0.5 0.9 -0.9
Worry (Nagel 2018) 3.0 6.4 12.8 1.1 1.8 3.6 2.9
Alzheimer’s Disease (in mother) 1.0 1.2 2.3 -0.2 1.5 -1.3 0.8
Alzheimer’s Disease (in father) 1.0 1.1 2.5 1.6 0.9 0.9 0.5
Alzheimer’s Disease (including proxy) 1.8 2.6 6.2 0.6 2.5 1.6 1.2
Crohns Disease (2017) 0.5 1.1 3.6 -0.3 -1.9 -0.5 0.6
Irritable Bowel Disease (IBD) 0.4 0.9 2.8 -0.3 -1.7 -0.8 0.1
Ulcerative Colitis (UC) 0.2 0.4 0.8 -0.4 -0.9 -0.4 -0.5
Major Depression (MDD) 2.7 3.3 6.9 1.4 0.4 2.6 2.0
Reaction Time 1.6 3.0 8.2 0.6 2.9 -1.9 0.0
Verbal and Numeric Reasoning (VNR) 3.9 9.4 11.9 3.4 3.4 3.5 1.5
Breast Cancer 0.5 1.2 4.2 0.3 0.3 -0.5 2.0
Ovarian Cancer 1.7 2.2 7.0 1.3 0.0 0.3 -2.6
Prostate Cancer 1.0 1.4 3.7 -0.0 1.4 1.9 -0.4
Age at First Birth 0.4 0.6 1.0 -1.0 -0.8 -0.6 -0.5
Bipolar Disorder (2011) 1.7 1.7 3.8 0.3 1.7 -0.1 1.9
Body Mass Index (BMI) (2010) 5.0 6.8 19.5 0.5 -1.1 -4.4 2.5
Coronary Artery Disease (CAD) 0.8 1.0 1.5 -1.2 -0.6 -1.0 1.1
Crohns Disease (2012) 1.1 1.8 3.5 -1.0 -1.9 -1.7 -0.1
Mean Putamen Volume 1.7 2.0 4.4 0.0 0.1 -2.1 1.9
Fasting Glucose 3.9 4.7 9.1 3.0 2.1 -2.3 -0.3
HbA1C 1.9 2.1 4.5 -1.5 -0.7 2.1 -1.0
HDL Cholesterol 13.8 23.0 57.2 5.5 7.6 1.9 0.5
LDL Cholesterol 0.2 0.3 0.7 0.4 0.8 0.2 0.5
Lupus 1.2 1.9 3.5 1.9 0.9 1.7 -0.5
Neuroticism (2016) 3.2 4.6 12.6 0.5 -0.4 3.5 2.4
Primary Biliary Cirrhosis 1.2 1.6 5.4 0.7 0.7 2.3 0.3
Rheumatoid Arthritis 0.5 0.7 1.3 0.3 -1.2 -0.2 -1.2
Schizophrenia (2014) 0.5 1.1 2.8 0.8 1.7 0.4 1.0
Triglycerides 0.6 0.9 1.4 0.7 -1.2 -0.8 1.2
Type 2 Diabetes (T2D) (2012) 4.3 5.0 12.7 1.9 1.1 -1.5 3.6
Ulcerative Colitis 1.5 2.2 4.0 -1.3 -1.2 -2.0 -1.3
Blood Eosinophil Count 0.3 2.5 4.7 -2.2 -1.9 -1.2 -0.6
Blood Platelet Count 3.4 39.7 112.4 -2.3 0.3 10.6 -6.4
Blood Red Count 0.4 3.9 8.5 -1.2 -1.6 -1.8 -2.9
Blood White Count 6.2 45.7 68.4 -7.3 -8.3 -4.8 -6.2
Heel T-Score 3.8 30.1 46.4 -1.4 6.3 -5.6 -6.8
BMI 4.3 25.0 69.6 -1.4 -4.1 -8.3 3.4
Height 3.6 69.2 98.2 9.9 9.6 7.3 5.7
Waist Hip Ratio (WHR) 2.9 12.8 20.2 4.5 3.9 -1.1 3.9
Systolic Blood Pressure 9.5 47.6 87.8 -6.2 -7.0 9.4 3.9
Smoking Status 1.2 3.0 9.5 1.2 3.1 0.3 1.0
Allergy or Eczema 0.6 1.6 2.9 1.2 0.7 1.2 1.7
Cardiovascular Disease 3.5 11.4 24.2 -2.8 -3.6 1.0 4.9
Hypothyroidism (self reported) 2.4 5.5 11.1 -1.1 -3.0 -3.3 -0.9
Respiratory disease 1.6 3.5 7.3 -0.0 -0.8 2.4 2.7
Type 2 Diabetes (T2D) (2018) 4.5 8.4 17.9 1.9 0.6 -4.2 3.4
Lung FEV1/FVC ratio 0.2 1.1 3.3 -1.8 0.7 0.5 -0.7
Lung FVC 0.4 2.1 4.6 -0.9 1.2 1.3 -2.1
Neuroticism 3.8 9.3 21.5 1.1 -0.1 4.6 3.8
Chronotype (morning person) 2.1 4.9 11.8 -0.9 -1.9 -1.8 3.4
Hair Pigment 0.3 9.9 23.8 3.5 4.9 -1.5 1.2
Tanning 0.3 3.9 13.8 0.3 1.3 3.7 -0.0
Hand grip strength (left) 3.2 8.5 29.6 -0.1 1.2 5.4 -1.7
Number of treatments/medications taken 1.7 3.1 9.8 0.1 -1.4 -0.9 3.1
Average weekly spirits intake 0.4 0.5 1.4 -0.2 -1.2 -0.4 -0.6
Sensitivity / hurt feelings 0.8 1.4 3.1 -0.3 -0.8 1.8 1.4
Frequency of depressed mood in last 2 weeks 3.0 4.3 8.2 1.6 0.6 2.5 2.9
Hearing difficulty/problems: Yes 0.5 0.8 1.6 0.9 -0.8 1.3 -0.6
Relative age of first facial hair 0.6 1.2 3.0 1.2 1.7 0.0 0.4
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 2.1 0.5 -0.7 0.4 1.5
Ever used hormone-replacement therapy (HRT) 3.2 4.0 9.9 -1.5 -3.2 -1.7 -1.2
Ever had hysterectomy (womb removed) 0.9 1.1 1.8 0.9 -1.3 -1.3 -0.1
Systolic blood pressure, automated reading 6.2 18.0 30.8 -4.7 -5.5 4.0 1.8
Eye problems/disorders: Diabetes related eye disease 1.4 1.6 4.9 -0.8 -0.9 -2.2 0.1
Angina 2.1 2.8 5.8 0.2 -1.1 -2.4 2.0
Medication for hormone replacement therapy 1.6 1.8 3.8 -2.0 -0.4 0.1 -1.8
Vitamin and mineral supplements 0.3 0.4 1.1 -0.2 0.5 -0.0 1.1
Supplements: Zinc 2.3 2.5 5.3 -0.8 0.2 2.3 -2.0
Medication: Co-codamol 1.3 1.6 2.8 1.3 0.1 -1.3 1.7
Medication: Metformin 5.1 7.2 13.0 2.2 0.5 -3.6 3.3
Diabetes (father) 1.0 1.2 2.0 -1.0 -1.3 -1.4 0.4
Diabetes (mother) 1.7 2.1 3.3 1.8 1.0 -1.0 1.8
Severe depression (siblings) 2.6 2.9 5.9 0.2 2.4 2.3 -0.2
Pack years adult smoking proportion 1.0 1.6 4.8 0.7 0.9 0.2 2.2
Impedance of leg (right) 0.5 2.2 2.8 1.3 1.7 1.6 -1.4
Leg fat-free mass (left) 1.0 5.4 14.9 2.2 1.2 -0.8 3.9
Trunk fat percentage 8.0 32.1 102.0 0.6 -2.7 -10.1 4.3
Hand grip strength (right) 1.9 5.1 19.6 -0.3 0.7 4.4 -0.3
Townsend deprivation index at recruitment 3.4 4.8 7.5 1.1 1.9 2.6 2.7
Current tobacco smoking 2.0 3.2 4.7 2.1 1.8 2.2 0.7
Average weekly fortified wine intake 1.8 2.1 6.8 -0.6 -0.9 0.6 -2.6
Maternal smoking around birth 1.2 1.7 4.9 -0.7 -1.2 0.1 2.2
Fed-up feelings 3.4 6.1 12.0 0.9 -2.1 2.7 3.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.8 2.4 7.0 0.3 -0.0 2.6 1.6
Relative age voice broke 0.2 0.4 0.7 -0.4 0.8 -0.4 -0.6
Taking other prescription medications 2.4 3.8 10.0 1.0 -0.6 -1.9 3.2
Age when periods started (menarche) 3.3 7.9 14.7 2.7 3.8 3.0 -0.9
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 1.4 -0.2 -1.2 0.2 0.0
Heel bone mineral density (BMD) T-score, automated (left) 2.6 6.0 12.7 -0.7 3.6 -2.6 -2.0
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.1 -0.5 -1.0 0.3 0.1
Qualifications: CSEs or equivalent 0.4 0.5 0.9 0.7 0.4 0.9 0.8
Serious illness, injury or assault to yourself 0.6 0.7 1.0 0.9 -0.5 -0.9 1.0
High blood pressure 5.3 14.8 32.6 -3.8 -5.7 1.2 3.4
Hayfever, allergic rhinitis or eczema 0.6 1.2 2.6 0.6 0.8 1.2 1.6
Multivitamins +/- minerals 0.8 1.0 1.9 -0.2 -1.0 1.4 -1.0
Stomach or abdominal pain in last month 2.5 3.1 3.9 2.0 2.0 1.6 1.5
Supplements: Glucosamine 1.2 1.6 3.2 -1.7 -0.4 0.3 -1.8
Diverticular disease/diverticulitis (self-reported) 1.5 1.8 4.5 0.5 0.9 -2.1 1.3
Medication: Atenolol 0.1 0.1 0.3 -0.3 -0.1 0.1 -0.5
Medication: Levothyroxine sodium 2.9 4.9 9.6 -2.1 -3.1 -2.3 -0.3
Sitting height 3.0 21.2 51.1 2.8 4.3 7.2 2.8
Chronic bronchitis/emphysema (father) 0.3 0.4 1.0 -0.5 0.5 0.1 1.0
High blood pressure (mother) 2.1 2.9 7.1 -0.8 -1.4 1.4 2.7
Body mass index (BMI) 4.6 19.4 53.3 -1.1 -3.5 -7.3 3.3
Impedance of leg (left) 0.3 1.7 2.7 1.6 1.4 1.1 -0.9
Leg predicted mass (left) 1.0 5.1 14.3 2.0 1.2 -0.8 3.8
Trunk fat mass 5.5 23.6 66.3 1.3 -1.6 -8.1 4.9
Waist circumference 4.6 16.8 39.3 1.9 -1.0 -6.3 4.8
Number of incorrect matches in round 1.9 3.2 6.4 0.7 0.8 -2.5 -2.3
Past tobacco smoking 0.1 0.2 0.4 0.2 -0.3 -0.6 0.5
Alcohol usually taken with meals 0.6 0.9 1.9 1.0 -0.2 -0.9 -1.4
Nervous feelings 2.0 3.8 8.3 0.3 1.3 2.9 2.2
Frequency of tenseness / restlessness in last 2 weeks 2.4 3.7 7.8 1.1 0.5 2.8 2.4
Hearing difficulty/problems with background noise 3.8 6.1 15.1 0.4 -2.9 3.9 -1.0
Hair/balding pattern: Pattern 2 1.8 2.3 3.5 -0.6 1.5 1.8 -1.9
Had menopause 0.2 0.2 0.7 0.9 0.1 -0.4 -0.0
Had other major operations 1.4 1.8 4.6 2.1 0.8 -1.1 0.8
Forced vital capacity (FVC) 2.5 9.5 15.9 3.0 4.0 3.6 -0.3
Heel bone mineral density (BMD) T-score, automated (right) 2.8 6.5 15.8 0.1 4.0 -2.6 -1.9
Ever unenthusiastic/disinterested for a whole week 2.9 3.6 7.8 1.5 1.5 1.5 2.8
Qualifications: None of the above 0.5 1.1 3.0 -0.9 -0.7 0.6 1.7
Financial difficulties in last 2 years 1.7 2.3 8.6 -0.1 -0.2 2.9 0.6
Mouth/teeth dental problems 0.8 1.2 1.7 -0.9 -1.2 0.9 -1.3
Heart attack 0.9 1.2 3.8 0.9 0.2 -0.4 2.0
Allergy 1.2 2.8 7.8 -0.5 -0.8 -1.6 -2.8
Pain all over the body in last month 0.8 0.8 1.2 -0.7 -1.1 -0.8 1.0
Diabetes (self-reported) 2.0 3.1 6.2 0.2 -0.0 -2.5 2.5
Hayfever/allergic rhinitis (self-reported) 1.4 1.8 3.8 1.9 -1.3 -0.3 1.3
Medication: Ramipril 1.2 1.5 3.6 -1.3 -0.5 0.7 1.9
Medication: Simvastatin 0.6 0.9 1.6 -0.8 -1.3 -0.4 1.1
Fluid intelligence score 4.5 9.4 16.0 3.3 4.0 2.8 1.7
Illnesses of siblings 1.6 2.3 4.6 2.1 1.8 0.6 -0.8
Neuroticism score 4.3 8.9 16.6 1.6 0.4 4.1 4.0
Weight 2.3 11.5 24.8 2.4 0.3 -3.9 5.0
Impedance of arm (right) 0.5 2.5 9.1 0.5 0.2 -3.0 -0.8
Arm fat percentage (right) 7.8 30.7 98.6 -0.8 -3.8 -9.9 3.0
Trunk fat-free mass 2.6 15.0 18.9 3.8 4.3 4.2 3.0
Hip circumference 2.7 11.4 24.1 -0.2 -2.9 -4.9 3.6
Time employed in main current job 1.2 1.4 4.3 0.5 2.1 -1.0 -0.2
Alcohol intake versus 10 years previously 1.3 2.0 7.8 0.1 0.3 -2.8 -0.2
Father’s age at death 0.8 1.1 3.6 -0.8 -0.4 -0.4 -1.9
Worrier / anxious feelings 2.1 3.9 8.6 1.1 1.7 1.7 2.9
Frequency of tiredness / lethargy in last 2 weeks 4.8 7.8 13.7 2.6 0.2 3.3 3.7
Falls in the last year 1.5 2.1 4.8 0.0 -0.7 2.2 1.7
Hair/balding pattern: Pattern 3 1.0 1.5 2.7 -0.5 -1.6 -0.8 1.5
Number of live births 1.2 1.6 5.2 -2.3 -1.0 0.4 -0.4
Forced expiratory volume in 1-second (FEV1) 1.7 5.8 11.1 1.4 3.0 3.3 -0.8
Pulse rate 1.0 1.7 4.7 1.3 0.4 -0.5 2.2
Happiness 0.6 0.7 1.3 0.6 -0.7 1.1 0.7
Noisy workplace 0.5 0.6 2.1 0.2 -0.3 0.5 1.4
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.6 0.8 0.6 0.2 -0.6
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 2.2 1.2 0.5 0.4 1.5
Mouth/teeth dental problems: Dentures 1.1 1.9 4.0 1.7 2.0 -0.7 0.6
Asthma 1.3 2.5 4.2 -0.9 -1.4 2.1 1.8
Medication: Ibuprofen (e.g. Nurofen) 0.0 0.0 0.1 -0.1 0.0 -0.2 0.3
Medication: Cholesterol lowering 0.8 1.3 4.9 0.1 -0.2 -0.5 2.2
Depression (self-reported) 2.2 2.6 7.9 0.2 0.9 1.3 2.8
Medication: Lansoprazole 0.8 0.9 1.7 1.3 0.4 -1.2 0.6
Prospective memory result 1.2 1.5 2.5 -1.4 -1.6 0.5 1.1
Lung cancer (father) 3.9 4.6 11.1 2.5 3.3 0.4 0.9
Illnesses of mother 1.5 1.9 7.1 0.1 0.1 -0.7 -2.7
Forced expiratory volume in 1-second (FEV1), Best measure 2.5 8.0 16.6 1.2 3.2 4.1 -1.8
Pulse wave Arterial Stiffness index 0.7 0.8 2.1 0.7 -1.4 0.5 0.6
Impedance of arm (left) 0.6 2.8 10.9 0.3 -0.3 -3.3 -0.3
Arm fat mass (right) 4.8 19.8 56.9 0.2 -2.5 -7.5 4.0
Trunk predicted mass 2.6 14.6 17.9 3.8 4.2 4.2 3.0
Standing height 4.4 43.7 61.0 7.6 7.8 6.3 4.0
Length of working week for main job 0.3 0.3 0.7 -0.4 -0.2 0.8 -0.7
Exposure to tobacco smoke at home 0.3 0.4 0.5 -0.7 -0.7 0.2 0.7
Breastfed as a baby 2.1 2.6 4.8 1.3 2.2 2.0 -0.3
Tense / ‘highly strung’ 1.3 2.2 5.7 -0.0 -0.1 1.8 2.4
Seen doctor (GP) for nerves, anxiety, tension or depression 2.5 3.9 9.5 0.1 0.7 3.1 2.3
Hair/balding pattern: Pattern 4 2.1 5.0 10.4 -2.6 -3.2 -1.7 -0.2
Birth weight of first child 1.9 3.5 10.0 3.2 1.8 -0.4 -0.6
Peak expiratory flow (PEF) 0.9 2.0 4.1 0.4 2.0 1.6 -1.0
Pulse wave reflection index 1.2 1.4 3.0 -0.7 -1.7 0.4 -1.4
Ever highly irritable/argumentative for 2 days 1.4 1.7 6.7 0.4 0.0 0.1 2.6
Loud music exposure frequency 1.1 1.3 2.0 0.0 -1.3 -1.4 1.2
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 4.2 2.1 0.7 -0.9 1.1
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 4.1 -0.4 0.2 -0.7 2.0
Blood clot in the leg (DVT) 1.6 2.1 3.2 0.4 1.8 1.8 1.3
Medication: Paracetamol 0.7 1.1 3.7 0.5 -0.5 -1.9 0.5
Headache pain in last month 0.6 1.0 2.6 1.0 1.6 -0.6 0.4
Medication for cholesterol, blood pressure or diabetes 1.4 2.3 4.1 1.3 2.0 -0.6 -1.8
Glaucoma (self-reported) 7.7 9.1 18.5 4.3 3.6 -0.0 2.3
Gout (self-reported) 0.8 1.1 2.4 -0.5 -0.4 1.2 1.6
Hypothyroidism/myxoedema (self-reported) 2.0 3.8 7.7 -1.8 -2.8 -2.0 -0.3
Medication: Amlodipine 2.1 3.0 6.9 -0.6 -2.6 1.1 1.9
Medication: Ventolin 100micrograms inhaler 1.2 1.5 4.1 2.0 0.0 0.8 1.1
Birth weight 2.4 5.2 6.5 2.2 2.5 2.5 1.8
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.4 -0.2 -0.1 0.7 0.3
High blood pressure (siblings) 2.7 3.9 7.8 -2.8 -2.4 0.5 1.4
Forced vital capacity (FVC), Best measure 3.2 11.7 21.4 2.4 4.3 4.6 -1.3
Body fat percentage 7.9 31.1 98.0 0.2 -3.2 -9.9 4.0
Leg fat percentage (right) 5.4 19.7 62.6 -0.5 -3.0 -7.9 2.6
Arm fat-free mass (right) 2.0 10.3 16.2 3.3 2.7 2.6 4.0
Exposure to tobacco smoke outside home 0.8 1.1 3.2 0.7 -0.6 0.6 1.8
Comparative body size at age 10 5.2 14.3 26.2 -2.3 -4.5 -5.1 2.3
Number of full brothers 2.8 3.5 6.4 -2.5 -0.7 2.4 -1.2
Worry too long after embarrassment 1.1 1.8 6.2 -0.2 -0.1 2.5 1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 2.1 0.5 1.2 1.3 1.4
Wheeze or whistling in the chest in last year 1.2 2.2 7.1 1.2 -0.3 0.4 2.7
Number of children fathered 0.9 1.1 3.5 0.1 0.8 -1.9 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.2 0.0 0.0 -0.4 0.4
Age at first live birth 0.8 1.4 3.5 -0.3 -1.4 -0.5 -1.9
Pulse wave peak to peak time 0.9 1.0 4.0 -0.0 2.0 -0.1 -0.2
Health satisfaction 2.5 3.2 8.4 1.5 0.1 1.5 2.9
Shortness of breath walking on level ground 2.9 3.5 9.6 1.8 -0.8 0.5 3.1
Qualifications: College or University degree 0.9 2.9 4.4 -2.1 -2.0 0.4 -1.8
Eye problems/disorders: None of the above 1.3 1.5 3.6 -1.4 0.4 1.9 -0.7
Mouth/teeth dental problems: Loose teeth 0.4 0.4 0.8 0.8 -0.2 0.5 0.9
Emphysema/chronic bronchitis 0.6 0.7 1.5 0.3 0.9 0.6 1.2
Medication for pain relief, constipation, heartburn 0.7 1.2 4.0 0.5 0.3 2.0 -0.5
Neck or shoulder pain in last month 0.9 1.2 2.6 0.7 -0.5 1.6 1.2
Medication: Blood pressure 3.9 6.8 13.1 -2.7 -3.6 1.6 2.1
Angina (self-reported) 2.0 2.7 5.8 0.3 -1.0 -2.4 1.9
Migraine (self-reported) 1.4 1.7 3.2 0.4 1.2 1.8 -1.5
Medication: Ibuprofen 0.1 0.1 0.4 0.1 0.1 -0.7 0.2
Medication: Allopurinol 3.3 4.4 7.5 -2.4 -2.0 2.7 0.5
Medication: Omeprazole 0.8 0.9 3.2 0.2 0.4 -1.8 0.5
Medication: Seretide 50 evohaler 1.5 1.8 6.6 0.5 0.2 0.6 2.6
Mean time to correctly identify matches 1.8 3.4 10.8 0.3 3.3 -1.4 -0.8
Heart disease (mother) 1.0 1.3 2.8 -1.4 -0.3 0.3 1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.6 3.8 -1.5 -1.9 -0.7 -0.2
Whole body fat mass 5.1 21.4 60.1 1.0 -2.0 -7.8 4.6
Leg fat mass (right) 4.1 15.7 43.0 0.2 -2.3 -6.6 3.8
Arm predicted mass (right) 2.1 10.8 16.6 3.6 2.9 2.2 4.1
Pulse rate, automated reading 2.1 6.9 10.6 2.8 2.2 -3.2 2.0
Alcohol intake frequency. 5.0 11.7 35.5 2.9 -0.1 -6.0 1.7
Comparative height size at age 10 2.3 12.7 19.9 4.5 4.3 2.7 2.2
Number of full sisters 1.1 1.4 3.3 -1.3 -0.5 1.8 0.7
Suffer from ‘nerves’ 6.5 10.2 24.4 2.1 2.8 4.9 2.1
Overall health rating 2.1 4.6 13.1 1.0 -1.4 1.6 3.6
Chest pain or discomfort 2.8 4.1 5.7 1.8 1.5 2.2 2.4
Had major operations 0.3 0.4 0.5 0.7 -0.5 0.6 0.7
Age at last live birth 1.2 1.8 6.8 -0.4 0.2 0.3 -2.6
Family relationship satisfaction 1.7 2.1 3.3 1.8 1.0 1.6 1.3
Leg pain on walking 1.1 1.4 2.9 0.6 -0.9 1.2 1.7
Qualifications: NVQ or HND or HNC or equivalent 2.6 3.2 6.2 1.4 2.5 -2.1 -0.4
Commuting to job workplace: Car/motor vehicle 2.4 2.7 4.0 0.7 1.7 -2.0 -1.9
Illness, injury, bereavement, stress in last 2 years 1.6 1.9 3.9 -0.9 -1.1 -1.4 -2.0
Medication: Aspirin 0.4 0.5 1.3 -0.5 -1.1 -0.5 0.6
Supplements: Vitamin C 0.3 0.4 0.8 0.6 0.5 -0.9 -0.4
Knee pain experienced in last month 2.7 4.3 10.9 2.0 3.3 -0.3 1.5
Hypertension (Self-reported) 5.3 14.6 30.2 -3.8 -5.5 1.1 3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.6 3.1 7.7 1.8 2.8 1.2 -0.0
Illnesses of father: Heart disease 1.2 1.7 6.1 0.2 -0.3 0.7 2.5
Illnesses of siblings: Diabetes 1.3 1.6 2.6 -1.6 -1.1 -1.6 0.2
Smoking status: Previous 0.1 0.2 0.2 -0.4 0.4 -0.4 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 2.7 5.6 10.6 2.3 3.2 2.5 0.5
Whole body fat-free mass 1.7 9.6 13.0 3.4 3.1 2.2 3.6
Leg fat-free mass (right) 1.0 5.5 15.2 2.2 1.2 -0.6 3.9
Arm fat percentage (left) 8.5 33.8 104.0 -1.1 -4.2 -10.2 3.4
Average weekly red wine intake 1.6 2.3 3.5 -1.6 -0.5 1.9 -1.7
Handedness (chirality/laterality): Left-handed 1.1 1.3 3.0 1.7 1.4 0.5 0.2
Mood swings 2.9 5.3 10.5 1.0 0.1 3.2 3.1
Loneliness, isolation 6.8 9.4 19.8 2.4 1.8 4.5 3.0
Long-standing illness, disability or infirmity 2.1 3.1 8.4 1.8 -0.1 -1.0 2.9
Ever had bowel cancer screening 1.3 1.5 3.0 0.9 1.4 -1.7 -0.7
Diabetes diagnosed by doctor 3.2 5.3 11.2 1.5 0.5 -3.4 2.7
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.1 3.1 1.0 1.8 -0.6 0.3
Friendships satisfaction 0.9 1.2 2.3 1.5 0.7 0.8 1.1
Qualifications: nursing, teaching 1.5 2.3 4.0 -1.5 -2.0 -0.8 -1.6
Commuting to job workplace: Walk 1.5 1.6 5.9 0.7 -0.3 0.1 2.4
Eye problems/disorders: Cataract 1.5 1.7 4.9 0.6 -1.2 -2.2 0.3
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 2.4 -1.3 -1.2 1.6 -0.8
Medication for cholesterol 2.0 3.0 6.6 2.6 2.1 0.0 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.6 -0.8 0.3 -1.3 0.4
Back pain experienced in last month 1.1 1.6 3.2 1.3 -1.1 1.8 0.5
Mineral and other dietary supplements 1.3 1.8 3.6 -0.4 1.8 -0.2 1.9
Breast cancer (self-reported) 0.2 0.2 0.5 -0.4 -0.1 -0.3 0.7
Asthma (self-reported) 1.3 2.6 4.2 -0.5 -1.2 2.0 2.1
Osteoporosis (self-reported) 1.7 2.1 3.5 0.6 -1.2 1.7 -1.9
Osteoarthritis (self-reported) 0.8 1.0 3.8 0.5 0.3 0.1 1.9
Medication: Aspirin 0.4 0.5 1.1 -0.2 -0.6 -0.7 1.1
Medication: Gliclazide 1.6 1.8 4.6 1.6 -0.2 -2.2 0.4
Illnesses of father: None of the above (group 1) 2.0 2.5 4.8 2.2 2.0 -1.1 -0.4
Smoking status: Current 2.3 3.6 5.4 2.3 2.0 2.0 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.3 6.7 -2.4 -0.1 1.0 -2.6
Whole body water mass 1.8 10.0 13.1 3.5 3.1 2.3 3.6
Leg predicted mass (right) 1.1 5.7 15.4 2.3 1.3 -0.7 3.9
Arm fat mass (left) 5.1 21.0 61.2 0.5 -2.3 -7.8 4.2
Number of self-reported non-cancer illnesses 2.4 4.2 10.4 0.5 -1.8 1.8 3.2
Average weekly champagne plus white wine intake 3.1 4.3 7.9 2.8 2.8 0.2 1.2
Miserableness 4.2 7.4 20.3 0.5 -0.9 4.5 2.8
Guilty feelings 3.8 5.7 11.8 -2.2 -1.7 3.4 1.7
Wears glasses or contact lenses 1.2 1.4 3.7 -1.9 0.1 -1.3 0.5
Ever taken oral contraceptive pill 2.1 2.3 4.4 1.9 1.0 2.1 -0.1
Hearing aid user 2.2 2.5 5.8 -0.2 -1.3 -2.4 1.6
Mother’s age at death 0.4 0.5 0.9 0.4 0.1 0.9 -1.0
Financial situation satisfaction 2.3 2.8 6.6 2.6 1.1 1.5 1.2
Tinnitus: Yes, now most or all of the time 1.5 1.8 2.6 1.6 1.0 -1.0 -1.6
Commuting to job workplace: Public transport 1.4 1.6 3.4 -1.8 -1.2 1.4 0.1
Eye problems/disorders: Glaucoma 13.0 15.4 31.3 5.6 4.6 -1.0 2.9
Medication: Blood pressure 2.2 4.2 9.3 -2.4 -3.0 0.3 1.3
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.7 -0.1 -0.8 -0.0 0.4
Supplements: Fish oil (including cod liver oil) 1.2 1.6 4.1 0.1 -1.3 -0.6 -2.0
High cholesterol (Self-reported) 1.0 1.8 6.7 0.3 -0.6 0.4 2.6
Medication: Bendroflumethiazide 2.4 3.7 6.5 -1.7 -2.6 1.4 1.8
Medication: Paracetamol 0.6 1.0 3.5 0.2 -0.5 -1.9 -0.4
Medication: Lisinopril 2.5 3.3 5.9 -1.9 -2.4 1.8 0.7
Medication: Atorvastatin 1.4 1.7 3.5 -0.1 1.0 -1.5 1.9
Illnesses of father: High blood pressure 2.1 2.6 4.0 -1.6 -1.1 1.7 2.0
Alcohol drinker status: Never 2.2 2.6 9.4 0.1 -0.8 -3.1 -0.7
Ever smoked 0.3 0.6 1.6 -0.3 0.4 1.2 -0.8
Basal metabolic rate 1.5 8.2 17.0 3.1 2.4 0.6 4.1
Leg fat percentage (left) 6.2 22.3 69.7 -0.4 -3.2 -8.3 3.0
Arm fat-free mass (left) 2.1 10.8 15.4 3.9 2.9 2.1 3.9
Number of operations (self-reported) 0.9 1.3 2.7 1.7 0.3 -1.5 0.2
Average weekly beer plus cider intake 2.2 3.1 9.7 0.1 1.7 3.1 -0.3
Irritability 2.7 4.6 13.3 1.7 1.5 0.2 3.6
Risk taking 0.4 0.6 1.1 1.0 0.8 0.2 -0.7
Ever had prostate specific antigen (PSA) test 0.8 0.9 2.5 -0.0 -1.1 -0.1 -1.6
Fractured/broken bones in last 5 years 3.0 3.9 13.7 -0.8 -0.5 3.7 -0.9
Age started oral contraceptive pill 0.5 0.7 1.9 1.4 -0.0 -0.2 -0.9
Diastolic blood pressure, automated reading 3.5 10.7 17.4 -4.2 -4.2 2.4 1.6
Ever depressed for a whole week 1.7 2.1 2.9 0.5 1.6 1.7 1.6
Unable to work because of sickness or disability 2.0 2.6 5.7 -0.9 0.4 2.0 2.4
Commuting to job workplace: Cycle 2.2 2.7 4.5 -2.1 -1.4 0.4 -2.0
Myopia 2.6 3.7 10.7 1.4 3.3 1.5 -0.0
Vascular/heart problems diagnosed by doctor 4.6 12.5 28.7 3.1 5.4 -0.8 -3.3
Cholesterol lowering medication 1.9 2.8 7.6 0.2 -0.6 -1.8 2.8
Medication: Omeprazole (e.g. Zanprol) 1.0 1.3 4.0 0.0 0.4 -2.0 1.0
Pain experienced in last month 1.3 2.2 5.4 -2.3 -0.7 0.7 -1.5
Supplements: Calcium 1.2 1.3 3.3 1.0 -0.1 1.8 -0.9
Basal cell carcinoma (self-reported) 2.1 2.5 8.2 -1.1 -2.9 0.7 -0.3
Heart attack/myocardial infarction (self-reported) 0.9 1.1 3.5 1.0 0.3 -0.1 1.9
Deep venous thrombosis (DVT) (self-reported) 1.4 1.8 2.9 0.4 1.6 1.7 1.3
Heart disease (siblings) 1.3 1.5 2.5 0.8 1.4 -1.6 1.1
Alcohol drinker status: Previous 2.8 3.2 6.2 2.5 0.6 -1.1 2.2
Pack years of smoking 1.2 1.7 5.2 0.8 1.0 -0.2 2.3
Impedance of whole body 0.2 1.1 2.9 1.0 0.7 -1.7 -0.2
Leg fat mass (left) 4.3 16.8 46.4 0.3 -2.3 -6.8 3.9
Arm predicted mass (left) 2.5 12.6 19.9 4.5 3.1 1.8 4.2