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chr17:17,400,972-18,923,818

Best TWAS P=3.67e-10 · Best GWAS P=8.05e-10 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	ALKBH5	0.19	0.18	lasso	2	0.17	1.0e-13	-5.1	-5.1	3.0e-07	0.87	0.44	0.56	FALSE
2	GTEx	Adipose Subcutaneous	TOP3A	0.12	0.03	lasso	3	0.03	1.1e-03	-4.3	5.3	8.6e-08	-0.68	0.11	0.74	FALSE
3	GTEx	Adipose Visceral Omentum	RP11-258F1.1	0.08	0.02	lasso	2	0.03	1.3e-02	-5.3	-5.3	1.4e-07	0.87	0.10	0.56	FALSE
4	GTEx	Artery Aorta	ALKBH5	0.08	0.05	lasso	7	0.06	5.2e-04	-5.5	-5.9	3.8e-09	0.81	0.02	0.94	FALSE
5	GTEx	Artery Aorta	TOP3A	0.13	0.11	enet	8	0.15	1.8e-08	-5.6	5.5	2.8e-08	-0.72	0.05	0.95	FALSE
6	GTEx	Artery Aorta	RP11-258F1.1	0.11	0.12	lasso	5	0.10	4.7e-06	-5.1	-5.6	2.2e-08	0.89	0.10	0.89	FALSE
7	GTEx	Artery Coronary	CCDC144B	0.14	0.02	lasso	5	0.02	5.2e-02	4.6	-5.8	8.9e-09	0.80	0.04	0.66	FALSE
8	GTEx	Artery Coronary	TOP3A	0.27	0.19	lasso	6	0.16	6.8e-06	-5.7	6.1	1.2e-09	-0.82	0.02	0.97	FALSE
9	GTEx	Artery Tibial	ALKBH5	0.17	0.16	lasso	5	0.15	4.8e-12	-5.1	-5.2	2.0e-07	0.88	0.40	0.60	FALSE
10	GTEx	Artery Tibial	CCDC144B	0.11	0.07	lasso	7	0.07	6.2e-06	-5.5	-5.5	3.7e-08	0.65	0.08	0.84	FALSE
11	GTEx	Artery Tibial	TOP3A	0.09	0.04	lasso	5	0.04	4.4e-04	-5.7	5.4	5.9e-08	-0.70	0.04	0.95	FALSE
12	GTEx	Breast Mammary Tissue (Male)	CCDC144B	0.07	0.01	lasso	3	0.02	9.9e-02	-5.7	-5.7	1.5e-08	0.74	0.02	0.32	FALSE
13	GTEx	Breast Mammary Tissue (Female)	ALKBH5	0.12	0.08	lasso	3	0.08	2.3e-03	-5.1	-5.1	2.7e-07	0.87	0.11	0.39	FALSE
14	GTEx	Colon Transverse	ALKBH5	0.16	0.08	lasso	4	0.07	3.4e-04	-5.1	-5.7	1.3e-08	0.88	0.04	0.89	FALSE
15	GTEx	Colon Transverse	TOP3A	0.11	0.04	lasso	5	0.07	3.5e-04	-5.1	5.8	6.4e-09	-0.90	0.02	0.97	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	SHMT1	0.15	0.00	lasso	4	0.00	2.5e-01	3.2	-5.3	1.4e-07	0.81	0.03	0.70	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	RP11-258F1.1	0.34	0.12	lasso	1	0.10	1.6e-04	-5.3	-5.3	1.4e-07	0.87	0.09	0.72	FALSE
18	GTEx	Esophagus Mucosa	ALKBH5	0.09	0.08	lasso	8	0.06	9.3e-05	-5.1	-5.5	3.6e-08	0.85	0.05	0.88	FALSE
19	GTEx	Esophagus Mucosa	LLGL1	0.38	0.39	lasso	6	0.39	8.0e-28	-6.0	-6.1	9.1e-10	0.96	0.01	0.99	FALSE
20	GTEx	Esophagus Mucosa	MIEF2	0.11	0.07	lasso	10	0.06	1.0e-04	-6.1	-5.2	2.0e-07	0.90	0.01	0.99	FALSE
21	GTEx	Esophagus Muscularis	TOP3A	0.07	0.00	lasso	4	0.00	3.0e-01	-6.1	5.9	3.1e-09	-0.90	0.02	0.82	FALSE
22	GTEx	Esophagus Muscularis	RP11-258F1.1	0.19	0.17	lasso	6	0.13	3.1e-08	-5.1	-5.2	2.4e-07	0.87	0.34	0.66	FALSE
23	GTEx	Heart Left Ventricle	RP11-258F1.1	0.09	0.06	lasso	2	0.04	2.4e-03	-5.3	-5.2	2.2e-07	0.86	0.06	0.85	FALSE
24	GTEx	Liver	RP1-178F10.3	0.18	0.17	enet	9	0.18	9.9e-06	-5.7	-5.9	2.8e-09	0.79	0.03	0.95	FALSE
25	GTEx	Lung	SHMT1	0.15	0.13	lasso	6	0.16	2.4e-12	-4.3	-5.2	1.5e-07	0.67	0.13	0.87	FALSE
26	GTEx	Lung	TOP3A	0.12	0.10	lasso	7	0.10	5.3e-08	-5.7	5.8	8.8e-09	-0.78	0.03	0.97	FALSE
27	GTEx	Muscle Skeletal	ALKBH5	0.10	0.09	lasso	3	0.07	2.0e-07	-5.1	-5.4	7.5e-08	0.89	0.21	0.79	FALSE
28	GTEx	Muscle Skeletal	RP11-258F1.1	0.09	0.10	lasso	2	0.09	2.2e-09	-5.3	-5.2	1.9e-07	0.87	0.35	0.65	FALSE
29	GTEx	Nerve Tibial	ALKBH5	0.27	0.19	lasso	3	0.16	1.1e-11	-5.3	-5.2	2.1e-07	0.87	0.39	0.61	FALSE
30	GTEx	Nerve Tibial	SHMT1	0.30	0.20	lasso	6	0.29	5.5e-21	-5.5	-5.5	3.5e-08	0.62	0.10	0.90	FALSE
31	GTEx	Skin Sun Exposed Lower leg	ALKBH5	0.16	0.14	lasso	3	0.13	1.0e-10	-5.1	-5.1	3.1e-07	0.87	0.39	0.61	FALSE
32	GTEx	Skin Sun Exposed Lower leg	TOP3A	0.09	0.05	lasso	4	0.05	6.7e-05	-4.3	5.3	1.1e-07	-0.64	0.06	0.79	FALSE
33	GTEx	Skin Sun Exposed Lower leg	MIEF2	0.13	0.03	lasso	4	0.05	4.0e-05	-5.2	-5.2	2.2e-07	0.74	0.04	0.95	FALSE
34	GTEx	Spleen	CTD-2303H24.2	0.32	0.02	enet	15	0.12	5.2e-04	4.1	5.4	6.1e-08	-0.60	0.07	0.52	FALSE
35	GTEx	Stomach	RP11-258F1.1	0.13	0.12	lasso	1	0.10	2.4e-05	-5.3	-5.3	1.4e-07	0.87	0.07	0.93	FALSE
36	GTEx	Testis	RP11-258F1.1	0.17	0.10	lasso	3	0.10	2.9e-05	-5.1	-5.2	1.9e-07	0.85	0.17	0.74	FALSE
37	GTEx	Thyroid	CCDC144B	0.11	0.07	enet	28	0.07	2.9e-06	-5.5	-5.6	1.8e-08	0.45	0.07	0.92	FALSE
38	GTEx	Thyroid	SHMT1	0.14	0.14	lasso	3	0.15	1.4e-11	-5.5	-5.5	4.0e-08	0.69	0.09	0.91	FALSE
39	GTEx	Whole Blood	CCDC144B	0.05	0.06	lasso	2	0.06	3.2e-06	-5.5	-5.2	2.0e-07	0.59	0.08	0.82	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	CCDC144B	0.28	0.13	enet	17	0.17	1.5e-21	-5.5	-5.5	4.4e-08	0.56	0.10	0.90	FALSE
41	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LLGL1	0.07	0.04	blup	53	0.03	6.6e-04	-5.6	-5.7	1.4e-08	0.82	0.04	0.73	FALSE
42	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ALKBH5	0.07	0.05	blup	63	0.05	2.1e-03	-6.1	-5.4	5.8e-08	0.90	0.01	0.89	FALSE
43	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	LLGL1	0.23	0.09	blup	52	0.09	3.0e-05	-5.6	-5.3	1.2e-07	0.74	0.01	0.92	FALSE
44	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SHMT1	0.11	0.05	lasso	3	0.04	4.0e-03	-5.5	-5.2	2.2e-07	0.60	0.01	0.56	FALSE
45	The Cancer Genome Atlas	Colon Adenocarcinoma	ALKBH5	0.14	0.07	lasso	4	0.09	5.5e-06	-5.1	-5.3	1.5e-07	0.87	0.11	0.89	FALSE
46	The Cancer Genome Atlas	Colon Adenocarcinoma	LLGL1	0.14	0.13	enet	8	0.14	3.2e-08	-6.1	-6.3	3.7e-10	0.96	0.00	1.00	TRUE
47	The Cancer Genome Atlas	Colon Adenocarcinoma	SHMT1	0.08	0.06	enet	9	0.06	1.6e-04	-5.5	-5.5	3.0e-08	0.69	0.01	0.98	FALSE
48	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ALKBH5	0.02	0.02	enet	4	0.02	3.9e-03	-5.1	-5.2	2.3e-07	0.87	0.03	0.65	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LLGL1	0.08	0.03	blup	52	0.05	1.9e-06	-6.0	-5.7	1.1e-08	0.86	0.01	0.99	FALSE
50	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SMCR7	0.07	0.02	lasso	3	0.01	8.3e-03	-5.2	-5.2	2.5e-07	0.79	0.03	0.42	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ALKBH5	0.05	0.05	lasso	3	0.04	1.7e-05	-4.8	-5.2	2.2e-07	0.89	0.04	0.94	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	ALKBH5	0.05	0.04	lasso	1	0.03	9.1e-05	-6.0	-6.0	2.6e-09	0.96	0.00	0.99	FALSE
53	The Cancer Genome Atlas	Lung Adenocarcinoma	LLGL1	0.05	0.02	enet	6	0.03	7.1e-05	-6.1	-5.9	4.1e-09	0.87	0.00	0.98	FALSE
54	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ALKBH5	0.02	0.02	blup	63	0.01	3.4e-02	-5.1	-5.4	6.0e-08	0.89	0.02	0.82	FALSE
55	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LLGL1	0.09	0.02	blup	52	0.04	4.9e-05	-4.3	-5.4	7.6e-08	0.78	0.04	0.94	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	LLGL1	0.10	0.04	lasso	7	0.04	7.5e-05	-5.2	-5.6	2.5e-08	0.88	0.01	0.98	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	SHMT1	0.08	0.03	lasso	3	0.02	1.9e-03	-5.5	-5.5	3.6e-08	0.67	0.01	0.77	FALSE
58	The Cancer Genome Atlas	Stomach Adenocarcinoma	ALKBH5	0.07	0.05	blup	63	0.06	2.0e-05	-5.1	-5.3	1.1e-07	0.88	0.01	0.98	FALSE
59	The Cancer Genome Atlas	Stomach Adenocarcinoma	LLGL1	0.09	0.06	enet	6	0.05	2.5e-04	-5.6	-5.9	3.4e-09	0.81	0.02	0.94	FALSE
60	The Cancer Genome Atlas	Stomach Adenocarcinoma	SMCR7	0.06	0.02	enet	7	0.04	9.1e-04	-5.7	-5.5	4.1e-08	0.75	0.01	0.70	FALSE
61	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ALKBH5	0.11	0.03	blup	64	0.04	1.8e-02	-6.1	-5.5	4.3e-08	0.83	0.01	0.78	FALSE
62	The Cancer Genome Atlas	Thyroid Carcinoma	SHMT1	0.05	0.03	lasso	5	0.03	1.1e-03	-5.7	-5.7	9.3e-09	0.73	0.01	0.93	FALSE