TWAS hub - CCDC144B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2140	0.0530	5.6e-17	0.050	0.122	0.156	0.135	0.152	9.7e-07	1.2e-14	1.5e-18	4.1e-16	5.0e-18
2	GTEx	Adrenal Gland	0.1445	0.0582	8.0e-04	0.076	NA	0.048	NA	0.045	1.1e-03	NA	8.2e-03	NA	1.0e-02
3	GTEx	Artery Coronary	0.1370	0.0580	2.1e-03	0.020	NA	0.008	NA	0.024	7.1e-02	NA	1.6e-01	NA	5.2e-02
4	GTEx	Artery Tibial	0.1101	0.0507	1.7e-04	0.070	NA	0.065	NA	0.067	3.5e-06	NA	8.7e-06	NA	6.2e-06
5	GTEx	Breast Mammary Tissue	0.1880	0.0760	3.4e-03	0.000	NA	0.062	NA	0.014	3.2e-01	NA	4.0e-04	NA	6.0e-02
6	GTEx	Breast Mammary Tissue (Male)	0.0693	0.0622	1.7e-01	0.006	NA	0.007	NA	0.022	2.3e-01	NA	2.1e-01	NA	9.9e-02
7	GTEx	Breast Mammary Tissue (Female)	0.3149	0.1135	1.0e-02	0.015	NA	0.011	NA	0.056	1.1e-01	NA	1.5e-01	NA	9.1e-03
8	GTEx	Cells Transformed fibroblasts	0.0590	0.0300	2.6e-03	0.015	NA	0.060	NA	0.047	2.3e-02	NA	2.9e-05	NA	2.0e-04
9	GTEx	Nerve Tibial	0.1086	0.0549	6.0e-03	0.022	NA	0.025	NA	0.039	1.1e-02	NA	6.9e-03	NA	8.8e-04
10	GTEx	Thyroid	0.1140	0.0510	6.0e-04	0.073	NA	0.073	NA	0.061	2.9e-06	NA	2.9e-06	NA	1.8e-05
11	GTEx	Whole Blood	0.0490	0.0250	4.7e-03	0.059	NA	0.018	NA	0.060	3.9e-06	NA	8.6e-03	NA	3.2e-06
12	ROSMAP	Brain Pre-frontal Cortex	0.2846	0.0607	0.0e+00	0.132	0.169	0.172	0.161	0.130	1.3e-16	3.7e-21	1.5e-21	3.5e-20	2.2e-16

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Alcohol intake frequency.	9.0	21.0	33.1	1.5	-4.9	-5.8	-5.5	-2.5	-5.7	-0.4	-4.9	-3.5	-5.6	-5.2	-5.5
Waist Hip Ratio (WHR)	8.9	39.9	67.9	2.0	-6.1	-7.8	-6.7	-5.8	-6.8	-4.3	-8.2	-4.3	-6.7	-6.9	-7.2
Alcohol drinker status: Never	6.2	7.4	14.3	1.8	-1.4	-3.3	-3.2	-2.5	-3.7	0.3	-2.0	-1.3	-3.7	-3.8	-2.9
Number of live births	5.7	8.1	15.8	1.1	-3.0	-3.0	-3.3	-2.0	-3.3	0.8	-2.1	-2.5	-4.0	-3.5	-3.7
Qualifications: College or University degree	5.4	17.0	39.4	-2.5	3.6	4.1	4.3	4.3	3.5	2.5	4.0	4.5	4.7	3.8	6.3
Lung FEV1/FVC ratio	5.3	27.1	54.0	1.2	-4.3	-6.4	-5.6	-3.9	-5.8	-2.3	-7.3	-2.8	-6.1	-5.5	-7.1
Qualifications: None of the above	5.3	11.3	15.7	3.0	-2.8	-2.0	-3.6	-4.0	-3.2	-3.3	-3.2	-3.9	-3.8	-3.1	-3.9
Depression (self-reported)	4.9	5.9	10.7	-0.9	2.3	3.3	2.3	2.8	3.0	0.3	2.4	0.9	2.8	3.0	3.0
Age at first live birth	4.9	8.6	19.1	-4.4	0.7	1.6	2.6	3.9	2.8	0.8	0.4	2.3	4.3	3.9	3.5
Number of full sisters	4.9	6.0	11.1	0.5	-2.1	-3.3	-3.0	-1.5	-3.3	0.5	-2.7	-1.0	-3.0	-2.8	-2.9
Ever had bowel cancer screening	4.0	4.6	11.4	-1.6	3.0	2.2	2.4	1.1	1.9	2.8	3.4	1.4	1.0	1.9	1.5
Back pain experienced in last month	4.0	5.8	9.5	-2.3	2.6	2.7	3.1	2.5	2.4	0.2	1.0	2.7	2.6	2.8	2.4
Age at First Birth	3.9	5.7	10.7	-3.3	2.4	1.5	2.4	2.3	2.5	-0.0	2.3	1.9	2.6	2.6	3.2
HbA1C	3.7	4.1	11.5	0.2	-1.9	-2.1	-2.5	0.6	-2.5	-0.3	-3.4	-1.7	-0.9	-2.4	-2.5
Ever used hormone-replacement therapy (HRT)	3.7	4.7	10.4	-0.4	2.2	3.2	2.0	1.4	2.5	3.0	3.0	1.3	1.2	1.5	2.2
Forced expiratory volume in 1-second (FEV1), predicted	3.7	7.7	16.3	2.3	-4.0	-4.0	-2.5	-0.6	-3.5	-1.2	-3.4	-1.4	-1.0	-3.2	-3.0
Depression (Nagel 2018)	3.6	5.5	13.3	-2.6	1.1	1.9	2.1	3.7	3.2	1.8	1.7	1.4	2.5	2.3	2.6
Mouth/teeth dental problems: Bleeding gums	3.5	4.5	9.2	1.6	-1.8	-0.8	-3.0	-2.8	-2.5	0.2	-2.1	-1.8	-2.5	-2.2	-2.3
Depressed Affect (Nagel 2018)	3.3	6.9	16.7	-2.2	1.7	2.6	2.8	3.7	4.1	1.2	1.6	1.7	2.8	2.9	2.7
Mood swings	3.3	6.0	13.1	-0.9	1.4	2.9	2.8	2.8	3.6	0.0	1.5	1.4	3.0	3.2	2.9
Coronary Artery Disease (CAD)	3.2	3.8	16.7	0.4	-4.1	-2.5	-1.5	-0.6	-1.9	0.4	0.0	-1.4	-2.2	-1.5	-2.7
Supplements: Glucosamine	3.2	4.1	6.8	-2.4	0.9	2.4	2.6	2.6	2.1	1.1	2.6	1.5	1.1	2.5	1.4
Neuroticism	3.1	7.6	13.0	-3.0	2.2	3.1	2.8	3.5	3.6	1.1	0.9	2.0	3.1	3.4	2.8
Sensitivity / hurt feelings	3.1	5.3	11.8	-1.5	2.4	3.1	2.6	0.5	3.2	-0.9	0.5	1.6	2.8	3.4	2.3
Qualifications: CSEs or equivalent	3.1	4.1	9.5	1.5	-1.0	-1.8	-1.7	-3.0	-2.1	-0.6	-1.7	-1.1	-3.1	-2.4	-2.5
Alcohol intake versus 10 years previously	3.1	4.6	13.1	-0.3	-3.6	-3.4	-1.9	-0.5	-3.1	0.7	-2.1	-0.5	-1.8	-2.4	-1.8
Neuroticism (Nagel 2018)	3.0	7.1	14.6	-3.3	2.4	3.2	2.5	2.9	3.8	1.1	0.8	1.7	2.5	3.2	2.9
Type 2 Diabetes (T2D) (2012)	3.0	3.5	7.7	0.5	-1.8	-2.3	-1.9	-1.7	-2.8	-0.6	-1.3	-1.3	-2.2	-2.2	-2.3
Tinnitus: Yes, but not now, but have in the past	3.0	3.2	6.8	1.6	-2.5	-1.5	-1.2	-1.4	-1.7	0.0	-0.8	-1.6	-2.6	-2.3	-2.4
Major Depression (MDD)	2.8	3.4	7.2	-1.2	2.0	1.9	2.1	0.7	2.6	-1.1	0.0	1.4	1.8	2.7	2.6
Comparative height size at age 10	2.8	15.4	30.1	5.5	-3.5	-4.0	-3.1	-3.6	-2.9	-2.6	-3.0	-3.7	-4.3	-5.4	-4.4
Impedance of leg (right)	2.6	12.4	28.8	0.5	-4.0	-5.0	-4.4	-1.4	-4.4	-0.7	-5.4	-2.6	-2.6	-3.9	-3.0
Number of full brothers	2.6	3.3	7.0	-1.1	-1.7	-2.6	-2.2	-1.2	-2.6	0.7	-1.5	-0.3	-2.5	-2.1	-1.5
Neuroticism score	2.5	5.2	9.4	-2.2	1.5	2.9	2.1	3.0	3.1	0.8	0.6	1.4	2.5	2.9	2.5
Hair/balding pattern: Pattern 3	2.5	3.8	5.9	-1.4	2.1	2.4	2.3	0.3	2.1	2.3	1.7	1.9	1.3	2.1	2.2
Basal cell carcinoma (self-reported)	2.5	3.0	7.0	-1.0	1.9	2.6	2.0	1.2	1.9	1.2	2.0	1.4	0.8	2.4	1.1
Intelligence (Savage-Jansen 2018)	2.4	7.4	14.8	-2.6	3.1	2.4	2.7	1.3	2.6	2.6	3.8	2.7	2.4	2.5	3.0
Verbal and Numeric Reasoning (VNR)	2.4	5.7	12.9	-2.0	2.4	2.6	2.4	0.7	2.7	1.6	3.6	2.2	1.7	2.8	2.6
Medication: Ramipril	2.4	3.1	5.9	-1.6	1.6	1.4	1.6	2.3	2.4	-0.2	-0.9	1.3	2.4	2.3	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.7	6.2	-2.5	0.9	1.9	1.5	2.5	2.4	1.5	1.6	1.1	2.0	2.1	2.3
Medication: Blood pressure	2.4	4.2	13.4	-0.8	2.0	3.7	1.8	-0.0	3.3	0.2	0.3	0.3	1.8	2.9	2.7
Had major operations	2.4	2.8	6.8	-2.5	1.2	1.4	1.6	0.9	1.7	1.7	2.6	1.3	0.7	1.5	1.9
Standing height	2.3	23.3	50.7	7.1	-4.8	-5.3	-4.6	-3.6	-4.7	-4.3	-4.3	-4.1	-3.0	-6.0	-4.6
Irritability	2.3	3.9	7.9	-2.8	1.5	2.2	1.9	1.7	2.3	1.4	1.2	2.0	1.4	2.4	2.1
Impedance of leg (left)	2.2	10.6	29.2	0.3	-3.9	-4.5	-3.9	-1.1	-4.0	-0.5	-5.4	-2.3	-2.3	-3.4	-2.7
Miserableness	2.2	3.8	9.4	-1.1	0.9	2.4	1.9	3.0	3.1	0.8	0.9	0.5	1.9	2.8	1.8
Mean Putamen Volume	2.1	2.4	6.2	-0.2	0.6	2.1	1.9	1.1	2.0	-0.5	1.7	1.2	1.5	1.6	2.5
Qualifications: O levels/GCSEs or equivalent	2.1	3.3	7.2	-0.5	1.9	0.4	1.8	2.7	1.2	1.6	2.5	2.0	2.2	0.7	2.5
Guilty feelings	2.1	3.1	7.6	-1.0	2.8	2.5	1.9	1.4	2.0	0.8	1.7	1.4	1.4	2.0	1.3
Lupus	2.0	3.1	8.0	2.4	-1.4	-2.1	-1.8	-1.4	-1.3	-0.6	-1.1	-1.3	-2.0	-2.8	-1.6
Height	2.0	37.7	77.6	8.8	-6.0	-5.8	-5.5	-5.3	-5.7	-6.9	-5.6	-5.1	-4.5	-7.3	-6.0
Average weekly fortified wine intake	2.0	2.3	6.4	-0.3	1.3	2.0	1.4	1.0	2.1	0.6	2.5	-0.2	1.9	1.7	1.2
Hearing difficulty/problems with background noise	2.0	3.1	6.4	-1.5	-0.5	1.6	2.2	2.5	2.2	0.6	1.4	1.4	2.5	1.7	1.8
Mouth/teeth dental problems	2.0	3.1	7.8	-1.8	1.1	1.1	1.9	1.9	1.9	1.7	1.3	0.9	2.8	1.7	2.2
Fluid intelligence score	2.0	4.2	9.8	-1.5	1.2	2.1	2.2	0.9	2.3	1.4	3.1	1.9	1.8	2.5	2.6
Hand grip strength (right)	1.9	5.2	9.1	-0.8	2.8	2.2	3.0	0.5	2.8	-0.2	1.7	2.6	2.7	2.9	2.5
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	7.0	1.5	2.3	2.6	1.5	-1.7	1.7	0.5	1.4	0.1	0.6	0.8	0.6
High blood pressure	1.9	5.3	12.3	-0.3	2.1	3.5	2.4	-0.2	3.4	-1.2	1.5	0.5	2.1	3.0	3.5
Peak expiratory flow (PEF)	1.9	4.4	9.1	0.8	-1.4	-2.8	-1.9	-1.5	-3.0	-1.2	-2.9	0.2	-1.6	-2.5	-2.9
Age at last live birth	1.9	2.7	7.1	-2.6	-1.2	0.4	0.9	2.7	1.6	0.2	-0.2	0.8	2.2	2.0	2.0
Hearing aid user	1.9	2.1	5.1	-2.3	0.7	0.8	0.9	2.1	1.1	1.7	1.0	0.6	1.8	1.4	1.8
Average weekly spirits intake	1.8	2.2	7.5	0.2	-1.2	-0.4	-1.9	-0.5	-0.5	0.3	-2.7	-2.3	-1.2	-1.0	-2.4
Handedness (chirality/laterality): Left-handed	1.8	2.2	4.1	0.2	-1.8	-1.2	-1.7	-1.7	-1.8	-1.5	-1.8	-0.1	-1.4	-2.0	-1.2
Supplements: Fish oil (including cod liver oil)	1.8	2.3	7.3	-1.5	0.9	1.8	1.8	0.5	2.7	0.3	1.5	-0.5	0.7	2.3	1.7
Systolic Blood Pressure	1.7	8.6	18.6	0.6	3.2	3.8	2.9	0.4	3.8	-2.5	0.1	1.8	3.6	3.8	4.3
Fed-up feelings	1.7	3.1	9.7	-0.9	-0.0	1.5	1.8	3.1	2.7	0.4	0.3	1.0	2.3	2.0	1.6
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	5.2	-2.0	1.5	2.2	1.1	1.8	2.3	1.0	0.9	0.3	1.4	1.7	2.0
Hypertension (Self-reported)	1.7	4.7	11.5	-0.5	1.7	3.2	2.4	0.1	3.3	-1.2	1.2	0.5	2.1	2.8	3.4
Tinnitus: Yes, now most or all of the time	1.7	2.0	7.6	-2.3	-1.2	0.8	0.0	2.7	-0.3	2.8	0.7	0.7	0.6	0.8	0.2
Impedance of whole body	1.7	8.6	17.6	0.6	-3.7	-4.1	-3.7	-0.6	-3.9	0.5	-4.2	-2.4	-1.9	-3.2	-2.4
Chronotype (morning person)	1.6	3.6	10.3	0.0	0.5	-1.5	-1.9	-2.4	-2.9	0.1	-1.9	-0.5	-3.2	-2.0	-2.3
Angina	1.6	2.1	5.3	-0.6	-1.5	-2.3	-1.3	0.1	-1.7	1.0	-2.2	-0.9	-1.2	-1.4	-1.6
Impedance of arm (right)	1.6	7.3	15.2	1.3	-3.1	-3.9	-3.3	-0.5	-3.6	1.8	-2.3	-2.7	-1.8	-3.5	-2.4
Lung cancer (father)	1.6	1.9	6.4	2.5	-0.8	-0.7	-1.4	-1.5	-1.4	-0.7	-1.1	-1.5	-0.7	-1.6	-1.7
Length of working week for main job	1.6	1.8	8.2	2.1	-1.2	-0.5	-0.8	-1.2	-0.8	-2.9	-1.7	-0.4	-0.2	-1.1	-0.6
Angina (self-reported)	1.6	2.2	5.3	-0.6	-1.4	-2.3	-1.2	-0.1	-1.7	1.1	-2.2	-0.8	-1.3	-1.5	-1.7
Neuroticism (2016)	1.5	2.1	7.1	-1.1	0.3	1.6	1.3	1.6	2.7	0.1	0.1	0.5	1.8	1.8	1.8
Rheumatoid Arthritis	1.5	2.1	11.8	1.2	-1.3	0.4	0.0	-2.3	-0.7	-3.4	0.0	0.0	-1.8	-0.9	-0.9
Loud music exposure frequency	1.5	1.6	4.1	2.0	-1.8	0.1	-1.5	-1.3	-1.0	-0.6	-0.6	-1.6	-0.7	-1.3	-1.4
Worry too long after embarrassment	1.5	2.5	7.1	-2.7	1.8	1.7	1.5	1.2	1.9	-0.1	0.3	1.1	1.2	2.2	1.1
Number of children fathered	1.5	1.7	6.4	0.7	0.6	1.3	1.6	-0.9	1.0	-1.3	0.2	1.4	1.3	1.6	2.5
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	3.8	0.4	-1.2	-0.9	-1.4	-1.9	-1.3	0.8	-2.0	-0.9	-1.2	-1.4	-1.8
Ever had prostate specific antigen (PSA) test	1.5	1.7	4.5	-0.0	1.5	1.8	1.0	0.8	2.1	-0.7	1.2	0.1	1.9	1.3	1.4
Alzheimer’s Disease (in mother)	1.4	1.6	11.2	-0.7	0.6	0.8	-0.1	1.1	0.5	3.3	2.2	-0.9	0.2	-0.0	0.0
Fasting Glucose	1.4	1.6	8.3	-2.9	0.4	1.4	0.6	1.9	1.1	1.5	0.9	-0.1	0.4	0.8	0.5
Triglycerides	1.4	2.3	5.8	-0.5	-0.9	-2.3	-1.7	-0.4	-2.4	0.3	-2.3	-0.4	-0.9	-1.8	-1.7
Blood Red Count	1.4	13.6	39.9	5.9	-0.7	-1.3	-2.3	-6.3	-1.4	-6.1	-3.7	-3.6	-2.2	-2.1	-2.3
Medication: Metformin	1.4	1.9	8.6	-0.6	-1.0	-1.1	-1.4	0.0	-1.1	2.9	-2.0	-0.7	-0.6	-1.4	-1.2
Current tobacco smoking	1.4	2.3	4.7	0.5	-2.2	-1.7	-1.8	-0.3	-1.5	0.5	-1.2	-2.0	-2.1	-1.6	-1.4
Age when periods started (menarche)	1.4	3.3	6.5	1.7	-1.3	-2.1	-2.1	-1.3	-2.2	-1.5	-2.5	-1.3	-1.4	-1.8	-2.0
Average weekly champagne plus white wine intake	1.4	1.9	5.1	0.9	1.1	1.6	1.6	2.2	1.0	0.5	1.9	1.2	1.3	0.9	1.2
Medication: Bendroflumethiazide	1.4	2.1	4.9	-1.4	1.5	2.0	1.3	0.0	1.5	-0.9	0.6	1.1	1.4	2.0	2.2
Alzheimer’s Disease (including proxy)	1.3	1.9	10.2	-0.5	1.3	1.1	0.5	1.3	1.4	3.2	2.2	-0.6	0.4	0.4	0.6
Body Mass Index (BMI) (2010)	1.3	1.7	4.7	0.1	0.7	1.4	1.8	0.6	2.2	0.6	2.1	0.8	0.6	1.7	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.8	6.4	-2.5	-0.4	1.0	0.8	2.3	1.4	1.1	-0.4	1.2	0.8	1.3	1.1
Heart attack	1.3	1.7	5.0	-0.4	-0.9	-1.2	-1.3	-1.6	-1.2	-0.2	-2.2	-1.4	-1.0	-1.4	-1.4
Mouth/teeth dental problems: Dentures	1.3	2.1	4.7	1.2	-1.5	-1.1	-1.6	-1.5	-0.8	-2.2	-1.3	-2.0	-1.8	-0.6	-1.1
Medication: Lansoprazole	1.3	1.5	6.2	1.6	1.2	2.0	-0.7	-2.5	0.2	0.8	-0.6	-1.2	-0.5	0.5	-0.5
Impedance of arm (left)	1.3	5.8	11.2	1.1	-3.2	-3.3	-3.0	-0.1	-3.3	1.4	-2.4	-2.5	-1.4	-2.7	-1.9
Tense / ‘highly strung’	1.3	2.1	5.1	-2.3	1.0	2.0	0.6	1.5	1.4	0.8	0.1	0.7	1.7	1.7	2.0
Family relationship satisfaction	1.3	1.6	3.6	-1.7	0.8	-0.1	1.0	1.6	1.1	1.3	1.1	1.5	1.9	0.8	1.2
Smoking status: Previous	1.3	2.0	4.1	-0.1	1.8	1.1	2.0	1.3	1.1	1.0	2.0	1.6	1.6	1.3	1.1
Smoking status: Current	1.3	2.0	4.3	0.4	-1.9	-1.7	-1.7	-0.4	-1.6	0.4	-0.8	-1.6	-2.1	-1.5	-1.4
Medication: Blood pressure	1.3	2.4	4.5	-1.8	1.3	1.9	1.7	0.8	2.1	-0.6	1.0	1.1	1.4	1.9	2.0
Diastolic blood pressure, automated reading	1.3	4.2	11.0	0.7	3.3	1.9	2.0	0.5	2.2	-0.7	1.7	1.6	2.5	1.8	3.2
Commuting to job workplace: Cycle	1.3	1.6	5.4	-1.1	0.5	1.2	1.1	1.4	1.4	-1.2	0.3	0.7	2.3	1.5	1.1
Heart attack/myocardial infarction (self-reported)	1.3	1.6	4.8	-0.4	-1.1	-1.3	-1.4	-1.4	-0.9	-0.1	-2.2	-1.6	-0.8	-1.4	-1.4
Hand grip strength (left)	1.2	3.3	6.5	-1.2	1.8	1.3	2.2	0.4	2.3	-1.0	0.9	2.6	2.3	2.1	2.1
Systolic blood pressure, automated reading	1.2	3.3	9.3	0.8	3.0	2.6	2.1	0.1	2.4	-0.7	0.9	1.3	1.5	1.8	2.1
Severe depression (siblings)	1.2	1.3	4.8	-0.5	1.4	1.5	1.4	0.3	2.2	-0.1	1.0	0.3	0.7	1.5	1.0
Waist circumference	1.2	4.5	9.9	2.4	-1.3	-1.6	-1.6	-3.1	-1.7	-1.9	-0.6	-1.4	-3.1	-2.5	-2.6
Past tobacco smoking	1.2	2.3	4.9	-0.3	-1.9	-1.2	-2.1	-1.1	-1.2	-0.9	-2.2	-1.7	-1.8	-1.2	-1.3
Pain all over the body in last month	1.2	1.3	3.8	1.2	-0.7	-0.8	-1.2	-1.0	-0.7	-1.0	-1.5	-0.7	-1.9	-1.2	-1.1
Medication: Simvastatin	1.2	1.8	10.4	-2.2	-0.2	0.5	-0.1	1.6	0.8	3.2	1.4	-0.7	0.0	0.4	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	9.9	0.4	-1.5	-3.1	-2.0	-0.5	-2.6	-0.8	-2.8	0.2	-1.3	-2.5	-2.5
Osteoarthritis (self-reported)	1.2	1.6	3.4	-0.9	0.0	1.4	1.8	1.2	1.7	0.5	1.9	1.1	0.5	1.4	0.8
Ever smoked	1.2	2.2	5.0	0.4	1.4	1.1	1.9	1.7	1.4	1.0	1.6	1.3	2.2	1.3	1.6
Unable to work because of sickness or disability	1.2	1.5	3.6	1.1	-1.4	-0.9	-1.3	-1.0	-1.2	0.1	-1.9	-1.1	-1.5	-1.3	-1.1
Lung FVC	1.1	5.6	11.4	-2.3	3.2	2.6	2.5	1.1	2.2	1.3	3.4	2.6	1.3	2.7	2.0
Townsend deprivation index at recruitment	1.1	1.5	3.9	0.9	-0.7	0.3	-1.3	-2.0	-1.1	0.6	-0.2	-1.7	-1.9	-0.7	-1.5
High blood pressure (mother)	1.1	1.6	4.8	1.1	2.0	1.8	1.1	-0.1	2.2	-0.7	0.6	0.0	1.1	0.7	1.3
Birth weight of first child	1.1	1.9	10.8	-3.3	0.4	-0.4	0.1	2.1	-0.3	2.6	0.3	0.4	-0.7	0.1	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	7.1	-1.8	0.9	1.4	-0.2	-0.2	-0.0	2.7	-0.6	0.6	-0.3	0.9	-0.6
Mineral and other dietary supplements	1.1	1.4	4.5	1.5	-0.4	-1.2	-1.7	-0.4	-1.5	-1.2	-2.1	0.1	0.5	-1.3	-0.6
Wears glasses or contact lenses	1.1	1.2	4.9	-1.8	-0.3	-1.0	0.1	1.4	-1.0	2.2	0.6	1.3	-0.4	-0.6	0.0
Risk taking	1.1	1.6	3.8	0.6	-0.1	1.0	1.3	1.1	1.6	-1.6	1.6	0.6	1.2	1.4	1.9
Fractured/broken bones in last 5 years	1.1	1.4	7.0	1.7	-0.6	0.1	-0.8	-0.7	-0.2	-2.6	-0.4	-0.6	-1.3	-1.5	-0.9
Ever depressed for a whole week	1.1	1.3	5.7	-0.4	-2.4	-1.6	-1.6	-0.6	-0.4	-0.7	-0.2	-1.7	-0.5	-0.7	-0.3
Blood White Count	1.0	7.7	21.3	-0.4	-2.5	-4.0	-2.7	-2.3	-3.6	-0.9	-4.6	-1.5	-2.4	-2.8	-2.4
Ever had hysterectomy (womb removed)	1.0	1.1	3.2	1.2	0.4	0.4	-0.6	-1.5	0.3	1.8	0.0	-1.1	-1.6	-1.0	-1.1
Diabetes (father)	1.0	1.2	2.8	0.0	-0.2	-1.2	-1.2	-1.4	-1.1	-0.5	-1.7	-0.1	-1.4	-1.1	-1.4
Relative age voice broke	1.0	1.6	7.7	1.6	0.4	0.8	1.3	-0.2	1.0	-2.8	1.5	1.3	0.1	0.6	0.8
Worrier / anxious feelings	1.0	1.9	6.2	-1.0	1.3	1.6	0.9	1.2	2.5	-0.6	0.1	0.1	1.6	1.4	2.1
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	4.3	-0.7	-0.9	-1.3	-0.7	-1.5	-0.8	-1.3	-0.3	0.1	-2.1	-0.8	-0.3
Exposure to tobacco smoke outside home	1.0	1.3	9.2	1.4	1.4	0.7	-0.2	-1.2	0.6	-3.0	-0.0	-0.5	0.1	0.4	0.3
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.9	0.6	2.0	1.4	1.2	0.5	1.2	0.8	1.4	0.5	1.4	0.9	0.4
Friendships satisfaction	1.0	1.2	2.7	-0.0	1.6	1.1	1.4	-0.5	0.4	0.2	1.2	1.5	1.1	1.1	1.6
Breast cancer (self-reported)	1.0	1.1	5.0	2.0	-0.5	0.8	1.2	-0.5	1.0	-2.2	0.4	0.2	0.4	0.7	0.4
Medication: Lisinopril	1.0	1.3	5.2	0.7	0.9	1.7	0.8	-0.5	1.3	-0.4	2.3	-0.3	0.1	1.0	1.6
Vascular/heart problems diagnosed by doctor	1.0	2.8	7.9	0.9	-1.2	-2.5	-1.9	0.1	-2.8	0.3	-0.7	-0.1	-1.4	-2.2	-2.5
Schizophrenia (2018)	0.9	1.8	8.4	-1.1	-1.3	-2.9	-1.2	1.7	-1.1	-0.7	-1.8	-0.9	-0.2	-0.8	-0.2
Bipolar Disorder (2011)	0.9	0.9	2.7	-1.6	0.2	-0.1	0.6	1.5	0.4	1.6	0.0	0.0	1.0	0.2	1.2
Cardiovascular Disease	0.9	3.1	8.9	-1.9	1.2	2.1	1.6	-0.1	2.7	-0.8	0.6	0.5	1.6	2.4	3.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	4.1	-0.6	-0.7	0.2	1.3	1.4	1.0	-0.4	1.4	0.8	1.1	1.1	2.0
Trunk fat mass	0.9	3.7	11.6	3.4	-1.3	-1.3	-1.6	-2.4	-1.8	-1.0	-0.1	-1.5	-2.4	-2.4	-1.8
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	5.0	-1.6	-0.7	0.6	1.2	2.2	1.6	0.6	0.1	0.8	1.1	1.1	1.3
Gout (self-reported)	0.9	1.3	5.0	1.3	-1.3	0.0	-1.4	-2.2	-1.0	-1.1	0.1	-1.3	-1.1	-0.4	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.7	0.9	0.5	0.7	1.2	-1.6	0.9	-1.6	0.0	0.7	-0.7	0.9	0.8
High cholesterol (Self-reported)	0.9	1.6	4.7	-1.6	-1.0	-0.8	-1.6	0.6	-0.7	2.2	-1.5	-1.3	-0.8	-0.8	-1.2
Myopia	0.9	1.3	4.7	-2.1	-1.7	-0.8	0.5	2.2	0.3	0.5	-0.9	1.1	0.2	0.7	0.5
Heart disease (siblings)	0.9	1.2	3.6	-0.9	-1.9	-0.7	-1.0	0.3	-1.0	1.3	-1.9	-0.8	-0.3	-0.2	-1.0
Breast Cancer	0.8	1.8	5.5	2.4	-0.2	-0.4	-0.9	-0.9	-2.0	1.1	-0.4	-0.2	-1.9	-2.0	-1.4
HDL Cholesterol	0.8	1.3	2.3	-1.3	1.1	1.5	0.8	1.4	0.6	0.7	1.0	1.4	1.0	1.2	1.0
Blood Platelet Count	0.8	9.1	30.4	-5.5	2.0	1.7	3.0	4.0	1.9	4.0	1.2	3.5	2.4	2.7	1.2
Had other major operations	0.8	1.0	4.3	2.1	1.6	1.5	0.5	-0.5	0.4	-0.6	1.0	-0.5	0.6	0.5	-0.1
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	5.8	0.4	-1.4	-2.3	-1.6	-0.6	-2.2	-0.8	-2.4	0.2	-1.2	-1.8	-2.4
Happiness	0.8	1.0	3.0	-1.0	-1.0	0.4	1.5	1.1	0.7	0.3	0.4	1.7	0.8	1.0	0.9
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.1	-1.1	1.4	0.6	1.2	1.7	1.6	0.9	1.8	1.2	1.4	0.9	1.7
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	4.5	0.8	-1.0	-2.1	-0.5	0.1	-1.7	-1.0	0.1	0.7	-0.8	-1.4	-1.8
High blood pressure (siblings)	0.8	1.2	3.6	0.5	1.0	1.4	0.5	-0.7	1.4	-0.1	1.2	-0.7	1.3	1.0	1.9
Comparative body size at age 10	0.8	2.3	6.6	1.7	1.6	2.1	1.6	0.6	2.6	-1.4	1.9	-1.0	0.2	0.9	0.3
Mouth/teeth dental problems: Loose teeth	0.8	1.0	5.7	-2.4	-0.3	-0.8	0.0	1.7	-0.2	1.2	-0.3	0.5	0.2	0.7	0.3
Mean time to correctly identify matches	0.8	1.5	4.5	-1.5	-1.0	-0.0	1.3	1.4	-0.3	2.1	0.8	1.7	1.2	1.0	0.6
Average weekly red wine intake	0.8	1.2	2.7	0.6	0.9	1.6	1.2	1.2	1.5	0.3	0.8	-0.3	1.6	1.5	0.5
Qualifications: nursing, teaching	0.8	1.2	2.9	-0.7	1.3	0.9	1.0	1.0	1.4	0.2	1.4	0.6	1.2	0.8	1.7
Number of self-reported non-cancer illnesses	0.8	1.4	4.3	-1.1	0.7	2.0	0.8	-0.8	2.1	-0.3	-0.1	-0.9	0.0	1.7	1.2
Mother’s age at death	0.8	1.0	4.3	-0.6	1.4	-0.1	0.8	0.7	0.2	1.6	2.1	1.1	-0.2	-0.0	0.2
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	2.6	1.6	0.4	-0.2	-0.9	-1.6	-0.5	-0.8	-0.8	-0.8	-1.1	-1.5	-1.0
Bipolar Disorder or Schizophrenia	0.7	1.6	6.9	-1.7	-0.8	-2.6	-1.0	2.1	-0.7	0.3	-0.8	-1.2	0.6	-0.5	0.6
Schizophrenia vs Biploar Disorder	0.7	0.9	3.2	-0.5	0.1	-0.8	0.9	1.2	0.3	1.1	-1.4	1.8	1.0	0.2	0.4
Ovarian Cancer	0.7	0.9	2.5	1.4	-0.3	-0.8	-0.6	-1.2	-0.5	-0.9	-0.0	-0.7	-1.2	-1.6	-1.0
LDL Cholesterol	0.7	1.0	4.2	-2.0	0.4	-0.3	0.2	1.7	0.4	1.0	0.4	0.8	1.2	0.9	0.8
Schizophrenia (2014)	0.7	1.6	5.2	-1.6	-0.7	-1.9	0.0	2.3	-0.1	-0.4	-1.2	0.4	1.7	0.3	1.4
Frequency of depressed mood in last 2 weeks	0.7	1.0	4.6	-1.1	-0.3	0.7	0.7	2.1	1.3	0.5	0.8	0.4	0.8	0.6	1.1
Medication for hormone replacement therapy	0.7	0.8	1.6	-0.1	1.0	1.3	0.6	0.9	1.2	1.3	0.6	-0.1	0.7	0.9	0.7
Vitamin and mineral supplements	0.7	0.9	3.8	1.0	0.2	-0.7	-0.9	-0.9	-1.0	-2.0	-0.9	-0.6	0.3	-0.8	-1.1
Medication: Co-codamol	0.7	0.8	4.5	1.4	-0.8	-0.4	-0.3	-1.0	-0.1	-0.9	-0.2	-0.7	-2.1	-0.5	-0.1
Trunk fat percentage	0.7	3.0	6.6	2.6	-1.2	-1.2	-1.7	-2.0	-1.8	0.1	-0.1	-1.4	-2.4	-2.3	-1.7
Taking other prescription medications	0.7	1.0	4.2	-0.1	1.8	2.1	0.0	-1.2	0.5	0.1	0.8	-0.6	-1.2	0.4	-0.3
Nervous feelings	0.7	1.3	4.1	-2.0	-1.3	-0.6	-0.8	1.9	-0.4	0.9	-1.7	-0.7	0.5	-0.2	-0.3
Hair/balding pattern: Pattern 2	0.7	0.8	6.2	-2.5	-0.5	0.5	0.5	0.4	-0.0	-0.5	-0.1	1.0	-0.4	1.2	-0.0
Weight	0.7	3.3	14.2	3.8	-1.0	-0.6	-0.8	-2.6	-0.9	-2.4	0.4	-1.1	-1.8	-1.9	-1.4
Trunk fat-free mass	0.7	3.9	18.3	4.3	-1.0	-0.8	-0.8	-2.4	-0.8	-3.5	-0.4	-0.9	-1.0	-1.9	-1.6
Prospective memory result	0.7	0.9	2.4	1.3	-0.1	-0.6	-0.9	-0.6	-0.3	-0.6	-0.5	-1.3	-1.6	-1.3	-1.0
Illnesses of mother	0.7	0.9	3.4	-0.8	-0.9	-1.6	-0.6	-0.4	-1.9	-0.5	0.2	1.1	-0.6	-0.5	-0.8
Trunk predicted mass	0.7	3.9	18.2	4.3	-1.0	-0.8	-0.8	-2.5	-0.8	-3.5	-0.3	-1.0	-1.0	-1.9	-1.6
Headache pain in last month	0.7	1.3	5.8	-2.0	-0.4	-1.4	-0.4	-0.6	-1.0	-2.4	-1.0	0.6	-0.8	-0.0	-0.2
Arm fat-free mass (right)	0.7	3.5	15.4	3.9	-0.8	-0.3	-0.6	-2.5	-0.6	-3.5	-0.3	-0.6	-1.4	-1.6	-1.4
Wheeze or whistling in the chest in last year	0.7	1.3	3.6	-1.9	-0.2	1.1	1.3	1.6	0.4	-0.5	0.7	1.4	0.9	1.4	0.8
Whole body fat mass	0.7	2.9	9.1	3.0	-1.1	-0.9	-1.3	-2.5	-1.3	-1.0	0.1	-1.3	-2.2	-2.1	-1.5
Loneliness, isolation	0.7	1.0	2.1	-1.4	0.2	1.1	0.6	1.5	1.3	0.9	-0.1	0.4	1.2	0.9	1.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.8	-0.7	0.9	1.7	1.4	0.4	1.4	1.1	1.0	0.6	-0.1	0.7	0.1
Basal metabolic rate	0.7	3.9	18.5	4.3	-0.8	-0.5	-0.8	-2.7	-0.8	-3.1	0.2	-1.0	-1.4	-1.9	-1.5
Cholesterol lowering medication	0.7	1.0	5.3	-1.6	-0.6	0.2	-0.4	1.4	0.5	2.3	-0.1	-0.2	-0.6	-0.0	-0.7
Alcohol drinker status: Previous	0.7	0.8	1.7	1.3	-1.3	-0.3	-1.0	0.1	-0.4	-1.0	0.1	-1.1	-1.2	-0.9	-1.1
Primary Biliary Cirrhosis	0.6	0.9	1.9	0.3	-0.3	-1.3	-1.1	-0.4	-1.3	1.0	-0.7	-0.6	-0.8	-1.4	-1.1
Type 2 Diabetes (T2D) (2018)	0.6	1.1	4.5	-1.0	0.0	-1.2	-1.0	-0.5	-1.4	0.9	-2.1	0.5	-0.1	-1.2	-0.6
Number of treatments/medications taken	0.6	1.1	4.9	-0.5	0.5	2.2	1.1	-0.0	1.6	0.5	0.6	-0.8	-0.5	1.1	1.0
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.0	-0.2	-0.2	-1.2	-0.4	0.6	-1.0	1.4	-1.4	-0.3	0.8	-0.4	-0.2
Supplements: Zinc	0.6	0.6	1.5	-0.9	0.9	-0.4	-0.1	-1.0	-0.7	1.2	1.2	0.7	-0.2	-0.2	0.7
Multivitamins +/- minerals	0.6	0.8	2.1	-1.4	-0.0	0.8	0.7	0.5	0.9	1.4	1.2	0.2	-0.7	0.7	0.8
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.6	0.3	0.4	-0.5	-1.0	-0.9	-1.2	-0.9	-1.3	-0.7	-1.1	-1.1	-0.3
Medication: Levothyroxine sodium	0.6	1.1	2.6	-1.4	-1.6	-1.2	-1.2	0.3	-1.2	0.6	-1.0	-0.2	-1.3	-0.6	-0.6
Financial difficulties in last 2 years	0.6	0.8	3.6	-0.3	-1.9	-1.8	-0.7	1.2	-0.3	0.0	-0.7	-0.7	-0.1	-0.4	-0.1
Pulse rate	0.6	1.0	2.6	-0.5	-1.3	-1.6	0.7	1.0	-0.1	-1.6	-1.1	1.2	1.1	0.2	0.5
Asthma	0.6	1.1	4.0	-0.8	1.1	2.0	1.0	0.1	0.9	-1.0	0.5	0.6	1.1	1.4	1.2
Medication: Cholesterol lowering	0.6	0.9	4.7	-2.2	-0.2	0.3	-0.3	0.6	0.5	1.7	-0.4	-0.9	0.5	0.3	0.8
Blood clot in the leg (DVT)	0.6	0.8	2.0	1.2	0.5	-0.3	-0.7	-1.4	-0.3	-0.9	-0.9	-0.6	-0.9	-1.3	-0.8
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.8	-1.2	-1.7	-0.2	-0.6	0.5	-1.2	-0.3	0.4	-0.6	-1.1	-0.4	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.3	-1.5	0.9	0.6	0.1	0.1	1.1	-0.3	1.2	0.1	0.2	0.6	1.4
Shortness of breath walking on level ground	0.6	0.7	3.6	-0.8	-0.7	-0.5	0.4	1.9	0.1	-1.3	1.1	0.4	-0.1	0.3	0.2
Medication: Ibuprofen	0.6	0.7	3.5	-0.4	0.2	0.5	0.6	0.2	1.1	-1.9	-0.7	-0.2	0.8	1.1	0.6
Medication: Seretide 50 evohaler	0.6	0.7	4.7	0.6	2.2	1.1	0.3	0.2	0.2	-0.6	1.1	-0.3	-0.5	0.7	-0.3
Arm predicted mass (right)	0.6	3.3	14.1	3.8	-0.5	-0.4	-0.6	-2.4	-0.8	-3.2	-0.3	-0.4	-1.5	-1.6	-1.6
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.6	0.6	-0.5	1.6	0.6	0.4	1.1	-0.5	-0.9	-0.4	0.9	1.1	0.8
Knee pain experienced in last month	0.6	1.0	5.2	-0.4	-1.4	0.5	1.1	0.9	1.0	-2.3	0.4	0.5	0.4	0.8	0.3
Illnesses of father: Heart disease	0.6	0.8	4.1	-2.0	-1.5	0.5	-0.1	-0.1	0.2	1.4	0.6	0.7	0.1	0.5	0.5
Whole body fat-free mass	0.6	3.4	18.1	4.3	-0.6	-0.3	-0.5	-2.4	-0.6	-3.1	0.2	-0.9	-1.0	-1.7	-1.4
Commuting to job workplace: Walk	0.6	0.7	1.9	0.5	-1.1	-1.4	-0.9	-0.9	-0.6	0.3	-0.0	-0.8	-0.3	-1.3	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	3.5	0.4	0.8	1.5	-0.1	-0.1	0.2	1.9	1.1	0.2	-0.7	0.1	-0.4
Asthma (self-reported)	0.6	1.1	3.6	-0.9	1.1	1.9	1.1	0.2	0.7	-1.1	0.6	0.9	1.0	1.3	1.2
Whole body water mass	0.6	3.5	17.7	4.2	-0.7	-0.4	-0.6	-2.5	-0.7	-2.9	0.2	-0.9	-1.2	-1.7	-1.5
Arm fat-free mass (left)	0.6	3.3	13.9	3.7	-0.4	-0.3	-0.5	-2.8	-0.4	-3.2	-0.0	-0.5	-1.2	-1.6	-1.4
Number of operations (self-reported)	0.6	0.8	2.7	1.0	1.3	1.7	0.7	-0.8	0.8	0.6	1.3	-0.6	-0.3	0.4	-0.4
Average weekly beer plus cider intake	0.6	0.9	3.0	-1.1	-1.7	-0.2	-0.2	0.0	-0.8	-1.5	-0.2	1.5	-0.7	0.4	0.6
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.9	-0.1	1.4	0.5	0.1	1.0	-0.2	1.3	1.1	0.5	-1.2	-0.3	-0.4
Arm predicted mass (left)	0.6	3.0	12.6	3.5	-0.6	-0.5	-0.5	-2.8	-0.6	-2.9	-0.1	-0.4	-1.2	-1.7	-1.4
Bipolar Disorder (2018)	0.5	0.8	2.2	-1.5	0.4	-0.6	0.1	1.3	0.3	1.3	0.0	-0.4	1.2	0.1	1.4
Worry (Nagel 2018)	0.5	1.1	2.9	-1.4	1.0	1.5	0.1	1.3	1.2	0.5	-0.3	0.0	1.0	0.9	1.7
Ulcerative Colitis	0.5	0.7	3.1	0.4	1.7	1.0	-0.1	-1.1	0.9	-0.4	0.0	-0.2	0.4	1.1	0.7
Hypothyroidism (self reported)	0.5	1.1	2.3	-1.5	-1.4	-0.7	-1.0	-0.6	-0.9	0.4	-1.5	-0.6	-1.5	-0.2	-1.2
Respiratory disease	0.5	1.1	2.8	-0.9	0.4	1.4	1.1	0.8	1.1	-0.7	0.5	0.1	1.7	1.6	1.2
Hearing difficulty/problems: Yes	0.5	0.8	2.5	-0.7	-1.3	0.7	0.0	1.6	0.8	0.7	0.6	-0.6	1.4	0.5	0.7
Leg fat-free mass (left)	0.5	2.6	14.7	3.8	-0.2	0.1	-0.5	-2.3	-0.5	-2.2	1.0	-1.0	-1.0	-1.4	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.4	-0.3	-0.4	-1.4	-0.7	-1.1	-1.3	0.5	-1.2	0.8	-1.8	-1.0	-0.7
Stomach or abdominal pain in last month	0.5	0.6	1.9	-1.0	-0.6	-0.3	-0.7	0.2	-1.3	-1.4	0.3	0.5	-0.8	-0.1	0.6
Medication: Atenolol	0.5	0.6	2.1	0.1	-0.0	-0.8	-0.8	-1.4	-1.0	0.7	-1.1	-0.6	-0.5	-0.6	-0.4
Leg predicted mass (left)	0.5	2.8	15.1	3.9	-0.1	0.1	-0.5	-2.4	-0.5	-2.2	1.0	-0.9	-1.2	-1.4	-1.2
Had menopause	0.5	0.6	1.6	0.9	0.7	0.3	1.0	0.5	0.6	1.2	1.2	0.7	0.4	-0.7	0.1
Allergy	0.5	1.0	3.4	0.5	-1.8	-0.7	-1.3	-0.0	-1.5	0.7	0.0	-0.4	-1.4	-1.2	-0.7
Hip circumference	0.5	2.3	10.7	2.2	1.5	1.9	1.4	-0.9	1.3	-0.4	3.3	0.7	-0.2	0.4	0.7
Exposure to tobacco smoke at home	0.5	0.6	1.4	0.9	-0.1	-1.2	-0.8	0.1	-0.7	-0.9	-0.6	-0.6	-0.7	-1.0	-0.6
Emphysema/chronic bronchitis	0.5	0.6	2.0	-0.6	-0.1	-1.4	-0.9	-0.0	-0.2	-0.8	-0.8	-1.3	-0.3	-0.7	-0.1
Migraine (self-reported)	0.5	0.6	1.8	-1.1	-1.2	0.1	-0.9	-0.8	-0.1	-0.1	-1.2	-1.3	-0.2	0.3	-0.4
Medication: Omeprazole	0.5	0.6	3.3	-0.0	0.7	0.1	-0.2	0.4	-0.5	0.8	0.4	0.3	-1.8	-0.7	-1.2
Chest pain or discomfort	0.5	0.8	3.5	-1.6	0.9	-0.2	0.3	0.9	-0.0	1.9	0.9	0.5	-0.2	0.4	-0.3
Leg pain on walking	0.5	0.6	1.7	-1.3	-0.9	-1.0	-0.4	-0.2	-0.7	-0.3	-0.2	0.1	-1.3	-0.4	-1.2
Medication for cholesterol	0.5	0.8	1.9	1.1	-0.5	-1.2	-0.7	-0.7	-1.4	-0.6	-0.5	-0.2	-0.7	-1.3	-0.9
Osteoporosis (self-reported)	0.5	0.6	3.7	0.6	0.7	-0.2	-0.1	-0.3	-0.1	0.3	1.9	-0.6	-1.0	-0.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	5.5	-0.8	2.3	0.1	0.1	-1.8	-0.2	-0.8	-0.3	1.1	-0.4	0.1	-0.4
Illnesses of father: High blood pressure	0.5	0.7	2.7	-0.2	1.6	0.1	0.3	-1.2	-0.4	0.8	-0.3	1.3	-0.6	-0.1	0.8
Irritable Bowel Disease (IBD)	0.4	1.0	5.6	1.4	1.1	0.8	-0.1	-1.1	0.5	-2.4	0.1	0.2	0.7	0.2	0.6
Ulcerative Colitis (UC)	0.4	0.7	2.8	1.2	0.2	-0.6	-0.9	-1.1	-0.4	-1.7	-1.3	-0.3	0.4	-0.1	-0.0
Reaction Time	0.4	0.8	3.4	-1.1	-1.9	-1.0	0.0	1.0	-1.1	1.0	-0.4	0.5	0.3	0.2	-0.6
Prostate Cancer	0.4	0.6	3.7	-0.0	-0.1	-0.1	0.3	-0.8	-0.1	-1.9	-1.4	0.7	0.3	0.2	-0.3
Crohns Disease (2012)	0.4	0.7	1.8	0.9	-0.3	1.3	0.4	0.3	1.2	-1.3	1.3	-0.5	0.6	0.2	0.4
BMI	0.4	2.0	7.1	-0.3	2.0	1.8	1.6	-0.9	1.5	-0.4	2.7	1.3	-0.0	1.3	0.9
Hair Pigment	0.4	12.0	41.0	-5.6	1.2	0.2	2.1	6.4	1.6	5.7	2.6	3.3	2.5	1.8	2.1
Diabetes (mother)	0.4	0.5	1.6	0.5	-1.3	-1.2	0.1	-0.2	0.0	0.3	-0.8	0.1	-0.8	-1.2	-0.2
Pack years adult smoking proportion	0.4	0.5	1.6	-0.3	-0.9	0.2	0.9	1.1	0.8	-0.6	1.3	0.4	0.2	0.9	0.4
Number of incorrect matches in round	0.4	0.7	2.4	1.6	1.4	0.8	0.6	-0.1	0.7	1.2	0.3	-0.0	0.8	-0.2	-0.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	-0.0	-0.9	0.0	-0.7	-0.9	-0.7	1.0	0.4	-0.4	-1.1	-0.9	-0.3
Diabetes (self-reported)	0.4	0.6	2.9	-1.5	0.2	-0.2	0.0	0.9	-0.3	1.7	-1.0	0.4	0.5	0.3	0.2
Illnesses of siblings	0.4	0.6	3.7	-0.3	0.7	-0.7	0.5	1.2	-0.3	-0.0	0.3	1.9	0.3	-0.2	-0.3
Falls in the last year	0.4	0.6	1.7	1.2	1.2	0.2	0.4	0.0	0.4	0.1	0.6	1.3	-0.5	-1.0	0.2
Noisy workplace	0.4	0.5	2.0	1.1	0.6	0.7	0.3	-1.1	0.3	-1.4	0.1	0.3	-0.2	-0.3	-0.5
Arm fat mass (right)	0.4	1.5	6.8	2.6	-0.3	-0.1	-0.3	-2.1	-0.5	-0.9	1.2	-0.6	-1.4	-1.3	-0.7
Hair/balding pattern: Pattern 4	0.4	1.0	6.1	2.5	1.0	0.1	-0.8	-0.6	-0.7	-1.0	-0.5	-1.1	-0.2	-0.6	-0.8
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.2	-1.1	-0.4	-0.4	-0.0	0.9	-0.8	-0.8	-0.4	0.9	-0.6	-0.2	-0.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.6	-1.6	-0.9	-0.5	-1.1	0.0	-0.7	0.9	-0.7	-0.4	-1.2	-0.0	-0.6
Medication: Amlodipine	0.4	0.6	1.6	-0.9	-0.4	1.1	0.0	-0.4	0.5	-1.1	-0.8	-0.8	-0.2	1.3	0.5
Body fat percentage	0.4	1.8	4.2	2.0	-0.8	-0.7	-1.2	-1.8	-1.3	0.2	0.4	-1.0	-2.0	-1.7	-1.1
Medication: Allopurinol	0.4	0.5	1.1	0.9	-0.5	0.9	-0.7	-1.0	-0.3	-0.6	0.4	-1.1	-0.0	0.6	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.9	-0.3	-0.4	0.1	-0.6	-0.1	-0.9	-0.7	-0.9	-0.6	-0.6	-0.5	-1.4
Leg fat mass (right)	0.4	1.5	4.6	2.0	-0.4	-0.5	-0.7	-2.1	-0.9	-1.0	0.4	-0.6	-1.8	-1.4	-1.1
Overall health rating	0.4	0.8	2.6	-1.4	-1.1	-0.9	-0.0	1.6	-0.5	-0.5	-1.1	0.8	0.2	0.2	0.4
Illnesses of siblings: Diabetes	0.4	0.5	3.5	-1.2	0.2	0.5	0.8	-0.1	0.0	1.9	-0.2	0.1	0.2	0.5	0.3
Leg fat-free mass (right)	0.4	2.0	12.5	3.5	0.0	0.4	-0.1	-2.0	-0.2	-1.9	1.1	-0.6	-0.8	-1.0	-0.9
Diabetes diagnosed by doctor	0.4	0.6	2.7	-1.0	0.3	-0.7	-0.2	0.4	-0.4	1.6	-1.6	-0.0	-0.1	-0.5	-0.2
Eye problems/disorders: Cataract	0.4	0.5	1.5	1.2	0.2	-0.9	-1.2	0.2	-0.6	-0.1	-0.2	-0.7	0.2	-0.8	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.1	0.9	0.6	1.1	1.2	-0.6	0.5	-0.4	1.4	0.9	-0.9	-0.2	-0.5
Leg predicted mass (right)	0.4	2.1	12.7	3.6	0.1	0.5	-0.1	-2.1	-0.2	-1.9	1.1	-0.6	-0.8	-0.9	-0.9
Arm fat mass (left)	0.4	1.5	6.3	2.5	-0.4	-0.1	-0.4	-2.0	-0.4	-1.1	1.1	-0.6	-1.4	-1.1	-0.8
Medication: Atorvastatin	0.4	0.5	1.3	-0.8	0.1	0.8	-0.1	0.8	0.6	-0.1	-1.2	0.0	1.1	0.6	0.9
Age started oral contraceptive pill	0.4	0.5	1.0	0.8	-0.4	0.2	0.6	0.8	1.0	0.6	0.8	-0.3	1.0	-0.3	0.6
Pain experienced in last month	0.4	0.6	2.0	1.3	-0.3	-0.2	-0.7	0.4	0.0	1.4	1.0	-1.1	0.8	-0.2	-0.0
Pack years of smoking	0.4	0.5	1.6	0.1	-1.1	0.2	0.9	0.8	0.8	-0.8	1.3	0.2	0.1	0.8	0.1
Leg fat mass (left)	0.4	1.4	4.7	2.1	-0.4	-0.4	-0.6	-2.2	-0.8	-0.9	0.4	-0.5	-1.7	-1.3	-0.9
Crohns Disease (2017)	0.3	0.7	3.3	0.9	0.2	1.2	0.3	-0.2	0.7	-1.8	1.2	0.3	0.4	-0.2	0.5
Blood Eosinophil Count	0.3	2.0	6.5	-1.1	0.1	1.2	0.4	-1.8	1.2	-2.5	-0.7	-0.5	1.6	1.7	1.9
Relative age of first facial hair	0.3	0.6	3.5	0.8	-0.8	-0.7	-0.6	0.0	-0.8	-1.9	0.5	-0.4	-0.7	-0.4	-0.4
Maternal smoking around birth	0.3	0.4	1.8	-0.3	-0.6	0.6	-0.9	0.2	-0.5	0.3	1.3	-0.7	-0.7	-0.5	-0.5
Sitting height	0.3	2.3	9.5	3.1	-0.5	-0.6	0.3	-0.0	-0.3	-2.9	-1.6	0.4	2.3	0.1	1.1
Chronic bronchitis/emphysema (father)	0.3	0.3	1.0	-0.6	-0.2	-1.0	-0.1	0.2	0.1	0.2	0.4	0.3	-1.0	-0.9	-0.8
Body mass index (BMI)	0.3	1.3	5.0	0.8	1.3	1.7	1.1	-1.3	1.1	-0.5	2.2	0.7	-0.6	0.5	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.7	0.4	-0.0	-0.5	-0.8	-1.0	-1.0	-0.1	-1.0	-0.3	-1.3	-0.8	-0.6
Time employed in main current job	0.3	0.3	1.0	1.0	0.7	1.0	0.6	0.7	0.5	0.2	0.0	0.3	0.3	0.0	0.3
Father’s age at death	0.3	0.3	1.4	0.4	-0.6	-0.2	-0.2	0.1	0.4	-0.4	-0.2	-1.2	-1.0	0.0	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	2.8	-0.1	-0.2	0.1	0.3	-0.2	0.5	-1.7	-0.8	0.0	-0.0	0.4	0.5
Pulse wave Arterial Stiffness index	0.3	0.4	1.4	1.0	0.1	0.7	-0.3	-0.4	-0.1	1.2	-0.4	-0.7	0.1	-0.3	-0.8
Pulse wave reflection index	0.3	0.4	1.7	0.2	1.0	1.3	0.3	-0.3	0.5	1.1	0.4	0.0	0.6	0.5	0.3
Birth weight	0.3	0.6	1.6	0.9	-0.4	-0.8	-0.6	-0.3	0.2	-0.5	1.0	-0.5	-1.3	-1.1	-0.9
Leg fat percentage (right)	0.3	1.1	3.5	0.8	-0.5	-0.8	-0.9	-1.8	-1.1	-0.5	0.3	-0.6	-1.9	-1.1	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.1	0.4	0.7	1.0	0.0	-0.2	0.4	0.1	0.5	-0.7	0.1	0.3	1.0
Pulse wave peak to peak time	0.3	0.3	1.5	-0.5	-0.4	-1.0	-0.1	0.1	-0.4	-1.2	0.1	0.4	-0.5	-0.2	0.4
Health satisfaction	0.3	0.4	1.3	-0.7	-0.6	1.0	0.9	0.1	0.1	-0.6	0.1	1.1	-0.2	0.7	0.7
Eye problems/disorders: None of the above	0.3	0.3	1.1	0.7	-0.5	0.9	0.2	-0.9	0.3	-0.0	0.5	-0.4	-1.1	-0.1	-0.3
Neck or shoulder pain in last month	0.3	0.4	2.5	-1.6	-0.2	-0.2	0.8	0.2	0.1	-0.1	-0.2	1.1	-0.0	0.4	0.3
Pulse rate, automated reading	0.3	1.0	2.2	-1.5	-0.3	-0.8	1.4	1.3	0.9	-0.2	-0.3	1.3	0.9	1.0	1.2
Suffer from ‘nerves’	0.3	0.4	0.9	-0.9	-0.6	0.9	0.4	0.8	0.6	0.2	0.3	0.3	0.5	0.9	0.9
Medication: Aspirin	0.3	0.3	0.8	-0.5	0.7	0.5	0.9	-0.2	0.6	0.3	0.6	0.4	-0.3	0.7	0.9
Medication: Gliclazide	0.3	0.4	1.2	-0.8	0.5	0.3	-0.3	0.3	0.2	-1.1	0.1	-0.6	0.7	0.9	0.7
Illnesses of father: None of the above (group 1)	0.3	0.4	1.8	1.3	-0.5	-0.1	0.3	0.5	-0.0	-0.9	0.1	-0.9	0.7	0.3	-0.4
Ever taken oral contraceptive pill	0.3	0.3	1.1	-0.1	0.8	0.5	0.5	-0.2	0.3	-0.1	-0.1	-0.1	1.0	0.7	0.8
Financial situation satisfaction	0.3	0.3	0.6	0.4	0.1	0.5	0.5	0.6	0.7	0.5	0.8	0.6	0.7	0.5	0.7
Commuting to job workplace: Public transport	0.3	0.3	0.9	0.6	0.6	-0.7	-0.2	-0.3	0.2	0.8	1.0	-0.2	-0.6	-0.7	0.3
Supplements: Calcium	0.3	0.4	1.1	0.5	0.2	0.1	-0.6	-0.5	-0.5	0.5	1.0	-0.2	-1.0	-0.8	-0.5
Allergy or Eczema	0.2	0.6	2.1	-0.9	-0.2	-0.8	0.7	0.6	0.7	-0.6	-0.8	0.5	1.5	0.4	0.4
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.6	-0.4	0.5	-0.3	1.0	0.2	1.1	-0.8	-0.5	0.2	1.3	0.7	0.3
Arm fat percentage (right)	0.2	0.8	4.1	1.5	0.1	0.1	0.1	-1.3	-0.1	0.5	2.0	-0.3	-1.0	-0.8	-0.1
Breastfed as a baby	0.2	0.2	0.9	1.0	0.4	-0.3	0.2	-0.1	-0.4	-0.2	0.1	0.3	-0.3	-0.8	0.4
Medication: Paracetamol	0.2	0.3	1.3	0.3	-0.7	-0.3	0.3	-0.2	-0.0	-0.9	-0.4	0.5	-1.1	-0.3	-0.1
Glaucoma (self-reported)	0.2	0.3	0.9	-1.0	-0.2	-0.1	-0.3	0.5	-0.8	0.4	-0.6	0.4	-0.3	-0.4	-0.7
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.2	-0.1	0.5	1.1	0.5	-0.7	0.6	0.3	0.5	-0.1	-0.4	0.0	0.5
Forced vital capacity (FVC), Best measure	0.2	0.9	2.6	0.8	-0.5	-1.6	-0.7	0.1	-1.3	-0.3	-0.7	0.4	-0.3	-1.5	-1.3
Medication for pain relief, constipation, heartburn	0.2	0.3	1.8	-0.6	0.4	0.1	-0.3	-0.2	-0.3	0.2	0.7	0.2	1.3	0.5	0.3
Heart disease (mother)	0.2	0.2	0.5	0.6	-0.3	0.5	0.5	-0.5	0.7	-0.4	-0.4	-0.1	0.4	0.5	0.5
Supplements: Vitamin C	0.2	0.2	1.2	0.7	0.1	0.1	0.2	0.5	0.2	-0.5	-0.4	0.2	0.6	-0.3	1.1
Arm fat percentage (left)	0.2	0.8	3.1	1.6	-0.1	0.2	-0.1	-1.2	-0.3	0.2	1.8	-0.5	-1.2	-0.7	-0.2
Long-standing illness, disability or infirmity	0.2	0.3	1.6	-0.5	-0.8	-0.1	-0.4	-0.8	-0.5	-0.1	0.1	-0.5	-1.3	-0.5	-0.2
Medication: Paracetamol	0.2	0.3	1.4	0.6	-0.6	-0.5	0.2	-0.2	0.3	-1.2	-0.3	-0.2	-0.9	-0.2	-0.1
Leg fat percentage (left)	0.2	0.8	3.5	0.9	-0.4	-0.4	-0.6	-1.9	-0.8	-0.5	0.4	-0.5	-1.7	-0.8	-0.6
Alzheimer’s Disease (in father)	0.1	0.1	0.4	0.2	0.5	-0.2	-0.3	0.2	0.4	0.7	0.2	-0.4	0.0	-0.3	0.3
Heel T-Score	0.1	1.1	6.1	0.1	2.5	0.1	-1.3	-1.1	-1.2	0.8	0.1	-0.5	-1.3	-0.3	-0.4
Smoking Status	0.1	0.3	0.7	0.3	0.2	0.3	0.8	0.7	0.7	0.4	0.9	-0.3	-0.3	0.4	-0.0
Tanning	0.1	1.6	9.0	3.0	0.5	1.3	0.1	-1.6	0.5	-1.6	0.3	-1.4	-0.3	0.2	0.0
Serious illness, injury or assault to yourself	0.1	0.2	0.6	-0.1	-0.8	-0.3	-0.1	0.5	0.5	-0.5	-0.2	-0.2	-0.4	-0.5	0.3
Alcohol usually taken with meals	0.1	0.2	0.7	0.7	-0.5	-0.2	0.1	0.3	0.3	-0.1	-0.8	-0.8	0.1	-0.2	-0.2
Forced vital capacity (FVC)	0.1	0.4	1.1	0.7	-0.2	-0.8	-0.2	0.1	-1.0	-0.2	-0.2	0.9	0.0	-0.8	-0.9
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.6	0.3	-0.3	0.3	0.2	-0.8	0.1	-0.3	-0.5	-0.2	-0.2	-0.1	-0.5
Medication: Aspirin	0.1	0.2	0.5	-0.7	0.3	0.1	0.5	0.1	0.3	0.6	0.1	0.2	-0.5	0.3	0.4
Eye problems/disorders: Glaucoma	0.1	0.2	0.7	-0.3	0.8	0.5	-0.1	0.3	0.2	-0.0	-0.6	0.0	0.1	0.1	-0.6

Hub : Genes

CCDC144B

Models

Trait associations