Best TWAS P=1.16e-14 · Best GWAS P=2.58e-14 conditioned to 0.000823
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ATG7 | 0.07 | 0.07 | lasso | 3 | 0.07 | 3.3e-09 | 7.6 | -7.7 | 1.2e-14 | -0.66 | 0.01 | 0.99 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | VGLL4 | 0.04 | 0.02 | blup | 511 | 0.02 | 7.8e-04 | 6.3 | 7.6 | 2.5e-14 | 0.74 | 0.07 | 0.89 | FALSE |
| 4 | GTEx | Muscle Skeletal | ATG7 | 0.06 | 0.02 | lasso | 4 | 0.03 | 8.6e-04 | 7.2 | -7.6 | 3.7e-14 | -0.62 | 0.05 | 0.92 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | ATG7 | 0.06 | 0.05 | lasso | 3 | 0.04 | 2.4e-06 | 7.5 | -7.3 | 3.1e-13 | -0.63 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Testis | VGLL4 | 0.18 | -0.01 | lasso | 3 | -0.01 | 6.9e-01 | 7.6 | 6.8 | 1.5e-11 | 0.50 | 0.03 | 0.48 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | ATG7 | 0.18 | 0.06 | lasso | 4 | 0.06 | 2.9e-04 | 7.5 | -6.6 | 3.4e-11 | -0.42 | 0.02 | 0.97 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ATG7 | 0.05 | 0.05 | lasso | 4 | 0.03 | 3.2e-04 | 7.5 | -6.5 | 9.3e-11 | -0.47 | 0.03 | 0.94 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | VGLL4 | 0.05 | 0.03 | blup | 422 | 0.04 | 3.7e-06 | 6.4 | 5.5 | 3.4e-08 | 0.80 | 0.16 | 0.83 | FALSE |