Best TWAS P=1.91e-09 · Best GWAS P=4.18e-09 conditioned to 0.143
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Hypothalamus | NME6 | 0.20 | 0.14 | lasso | 9 | 0.11 | 1.7e-03 | 5.4 | -5.7 | 1.6e-08 | -0.90 | 0.04 | 0.85 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Male) | FCF1P2 | 0.09 | 0.01 | lasso | 4 | 0.03 | 8.6e-02 | 5.1 | -5.5 | 4.7e-08 | -0.89 | 0.05 | 0.41 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | MAP4 | 0.19 | 0.15 | lasso | 5 | 0.16 | 4.2e-12 | 5.6 | -5.4 | 7.2e-08 | -0.92 | 0.05 | 0.95 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | MAP4 | 0.04 | 0.04 | enet | 7 | 0.04 | 2.0e-04 | 5.6 | -5.5 | 4.1e-08 | -0.88 | 0.04 | 0.92 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | CSPG5 | 0.10 | 0.10 | lasso | 5 | 0.09 | 4.6e-12 | 5.8 | 6.0 | 1.9e-09 | 0.85 | 0.02 | 0.98 | TRUE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | MAP4 | 0.06 | 0.05 | blup | 64 | 0.05 | 8.8e-04 | 5.3 | -5.6 | 1.9e-08 | -0.92 | 0.05 | 0.81 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | MAP4 | 0.03 | 0.04 | blup | 64 | 0.04 | 1.6e-05 | 5.2 | -5.5 | 3.8e-08 | -0.94 | 0.07 | 0.92 | FALSE |