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chr11:64,669,105-66,456,387

Best TWAS P=1.61e-11 · Best GWAS P=5.38e-11 conditioned to 0.00296

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
42	GTEx	Stomach	MAP3K11	0.09	0.02	lasso	3	0.04	4.4e-03	-5.8	-6.7	1.6e-11	-0.63	0.06	0.71	TRUE
5	GTEx	Adrenal Gland	CTSW	0.13	0.08	lasso	12	0.06	3.0e-03	6.6	-6.5	1.0e-10	-0.93	0.01	0.96	FALSE
44	GTEx	Thyroid	MAP3K11	0.20	0.19	lasso	8	0.21	4.4e-16	-5.9	-6.5	1.0e-10	-0.46	0.12	0.88	FALSE
26	GTEx	Liver	CTSW	0.27	0.03	lasso	13	0.02	1.0e-01	5.2	-6.4	1.4e-10	-0.90	0.02	0.70	FALSE
8	GTEx	Artery Coronary	FIBP	0.13	0.01	lasso	5	0.04	1.3e-02	5.1	6.3	2.8e-10	0.88	0.02	0.87	FALSE
71	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FIBP	0.04	0.01	blup	43	0.01	1.1e-02	5.1	6.3	2.8e-10	0.81	0.02	0.38	FALSE
20	GTEx	Colon Transverse	CTSW	0.37	0.27	lasso	8	0.26	1.5e-12	5.1	-6.2	6.3e-10	-0.85	0.10	0.90	FALSE
17	GTEx	Cells Transformed fibroblasts	EFEMP2	0.06	0.06	lasso	3	0.07	7.8e-06	5.2	6.1	8.1e-10	0.93	0.00	0.99	FALSE
61	The Cancer Genome Atlas	Glioblastoma Multiforme	CTSW	0.16	0.18	enet	16	0.19	2.3e-06	6.6	-6.1	8.9e-10	-0.93	0.01	0.99	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	CTSW	0.27	0.22	lasso	12	0.22	1.9e-12	5.1	-6.1	1.1e-09	-0.88	0.08	0.92	FALSE
15	GTEx	Breast Mammary Tissue (Male)	CTSW	0.53	0.19	enet	19	0.25	1.7e-06	5.1	-6.0	1.8e-09	-0.78	0.04	0.93	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	FIBP	0.03	0.03	blup	45	0.03	2.6e-07	4.9	6.0	1.8e-09	0.82	0.08	0.92	FALSE
29	GTEx	Lung	MAP3K11	0.08	0.08	lasso	5	0.07	4.4e-06	-5.8	-6.0	2.1e-09	-0.42	0.20	0.78	FALSE
80	The Cancer Genome Atlas	Thyroid Carcinoma	MAP3K11	0.04	0.04	lasso	2	0.03	6.9e-04	-5.8	-6.0	2.7e-09	-0.36	0.00	0.97	FALSE
77	The Cancer Genome Atlas	Soft Tissue Sarcoma	SNX32	0.08	0.08	lasso	2	0.10	1.5e-06	5.2	5.9	3.4e-09	0.85	0.05	0.94	FALSE
14	GTEx	Breast Mammary Tissue	MAP3K11	0.10	0.15	lasso	1	0.13	2.2e-07	-5.9	-5.9	3.6e-09	-0.36	0.14	0.84	FALSE
31	GTEx	Nerve Tibial	MAP3K11	0.11	0.16	lasso	1	0.15	9.4e-11	-5.9	-5.9	3.6e-09	-0.36	0.10	0.90	FALSE
2	GTEx	Adipose Subcutaneous	MAP3K11	0.08	0.12	lasso	2	0.12	7.1e-10	-5.9	-5.9	3.8e-09	-0.36	0.11	0.89	FALSE
34	GTEx	Prostate	MAP3K11	0.27	0.24	lasso	2	0.21	4.6e-06	-5.9	-5.9	3.8e-09	-0.36	0.13	0.64	FALSE
38	GTEx	Skin Sun Exposed Lower leg	MAP3K11	0.08	0.07	lasso	3	0.06	6.0e-06	-5.9	-5.9	3.9e-09	-0.36	0.11	0.86	FALSE
10	GTEx	Artery Tibial	MAP3K11	0.20	0.23	lasso	9	0.21	1.9e-16	-5.9	-5.9	4.2e-09	-0.36	0.10	0.90	FALSE
24	GTEx	Esophagus Muscularis	MAP3K11	0.19	0.20	lasso	7	0.20	4.9e-12	-5.9	-5.9	4.3e-09	-0.35	0.12	0.88	FALSE
55	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SNX32	0.05	0.05	blup	60	0.03	1.1e-03	4.4	5.8	4.8e-09	0.77	0.27	0.54	FALSE
47	METSIM	Adipose	BANF1	0.10	0.06	bslmm	343	0.07	4.9e-10	5.1	-5.8	4.9e-09	-0.60	0.81	0.19	FALSE
21	GTEx	Colon Transverse	MAP3K11	0.19	0.18	lasso	5	0.17	2.4e-08	-5.9	-5.8	5.7e-09	-0.37	0.12	0.87	FALSE
12	GTEx	Brain Cerebellar Hemisphere	EFEMP2	0.35	0.15	enet	5	0.09	2.2e-03	4.9	5.8	6.5e-09	0.88	0.02	0.93	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	EFEMP2	0.04	0.02	lasso	5	0.02	1.4e-05	4.9	5.8	6.7e-09	0.85	0.02	0.98	FALSE
45	GTEx	Whole Blood	CTSW	0.08	0.01	enet	11	0.04	5.4e-05	5.1	-5.8	7.5e-09	-0.69	0.33	0.64	FALSE
75	The Cancer Genome Atlas	Rectum Adenocarcinoma	CTSW	0.21	0.05	blup	39	0.07	9.1e-03	5.1	-5.8	7.5e-09	-0.79	0.04	0.36	FALSE
54	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CTSW	0.12	0.16	enet	12	0.17	5.6e-14	5.1	-5.8	7.6e-09	-0.78	0.83	0.17	FALSE
40	GTEx	Spleen	MAP3K11	0.34	0.38	lasso	5	0.38	1.0e-10	-5.9	-5.8	8.6e-09	-0.39	0.18	0.80	FALSE
13	GTEx	Brain Cerebellum	EFEMP2	0.45	0.40	enet	8	0.39	1.6e-12	5.1	5.7	9.4e-09	0.86	0.06	0.94	FALSE
46	GTEx	Whole Blood	MAP3K11	0.12	0.07	lasso	6	0.08	1.1e-07	-5.8	-5.7	1.1e-08	-0.39	0.22	0.78	FALSE
49	METSIM	Adipose	MAP3K11	0.22	0.26	lasso	10	0.26	1.4e-38	-5.9	-5.7	1.3e-08	-0.35	0.16	0.84	FALSE
16	GTEx	Breast Mammary Tissue (Male)	MAP3K11	0.23	0.09	lasso	4	0.02	1.4e-01	-5.6	-5.6	1.9e-08	-0.32	0.09	0.13	FALSE
59	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CTSW	0.21	0.16	blup	44	0.17	7.5e-09	5.1	-5.6	1.9e-08	-0.81	0.22	0.78	FALSE
25	GTEx	Heart Left Ventricle	FIBP	0.12	0.09	lasso	3	0.07	9.8e-05	5.1	5.6	2.1e-08	0.79	0.13	0.86	FALSE
78	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CTSW	0.26	0.29	lasso	9	0.27	4.7e-10	5.1	-5.6	2.4e-08	-0.78	0.64	0.36	FALSE
43	GTEx	Thyroid	CTSW	0.18	0.22	lasso	2	0.21	4.6e-16	5.1	-5.5	3.2e-08	-0.77	0.85	0.15	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	EFEMP2	0.01	0.00	blup	45	0.01	3.0e-02	3.6	5.5	3.6e-08	0.77	0.03	0.35	FALSE
56	The Cancer Genome Atlas	Breast Invasive Carcinoma	CTSW	0.25	0.39	blup	44	0.41	7.3e-91	5.1	-5.5	3.8e-08	-0.74	0.90	0.10	FALSE
1	GTEx	Adipose Subcutaneous	CTSW	0.30	0.18	lasso	6	0.16	3.9e-13	5.1	-5.5	3.9e-08	-0.75	0.46	0.54	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	MAP3K11	0.07	0.08	lasso	3	0.07	7.6e-05	-5.6	-5.5	5.1e-08	-0.33	0.18	0.68	FALSE
7	GTEx	Artery Aorta	MAP3K11	0.15	0.15	lasso	4	0.13	1.8e-07	-4.7	-5.4	5.4e-08	-0.34	0.44	0.56	FALSE
50	NTR	Blood	CTSW	0.20	0.18	enet	23	0.19	1.3e-57	5.1	-5.4	6.1e-08	-0.73	0.92	0.08	FALSE
30	GTEx	Nerve Tibial	CTSW	0.22	0.19	lasso	7	0.18	1.3e-12	5.1	-5.4	6.2e-08	-0.74	0.69	0.31	FALSE
69	The Cancer Genome Atlas	Lung Adenocarcinoma	FIBP	0.02	0.01	blup	45	0.02	1.3e-03	5.1	5.4	7.5e-08	0.75	0.08	0.27	FALSE
19	GTEx	Colon Sigmoid	CTSW	0.11	0.06	lasso	3	0.07	1.4e-03	5.1	-5.4	7.7e-08	-0.75	0.03	0.87	FALSE
6	GTEx	Artery Aorta	CTSW	0.29	0.26	lasso	7	0.25	3.2e-14	5.1	-5.4	7.9e-08	-0.72	0.79	0.21	FALSE
70	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CTSW	0.25	0.34	enet	14	0.34	4.1e-40	5.1	-5.4	7.9e-08	-0.73	0.90	0.10	FALSE
39	GTEx	Small Intestine Terminal Ileum	CTSW	0.41	0.29	lasso	13	0.27	1.1e-06	5.2	-5.4	8.2e-08	-0.74	0.22	0.67	FALSE
37	GTEx	Skin Sun Exposed Lower leg	CTSW	0.19	0.19	lasso	6	0.18	1.1e-14	5.1	-5.4	8.4e-08	-0.74	0.83	0.17	FALSE
51	ROSMAP	Brain Pre-frontal Cortex	EFEMP2	0.08	0.09	enet	13	0.09	6.8e-12	-4.7	5.4	8.5e-08	0.77	0.46	0.54	FALSE
62	The Cancer Genome Atlas	Glioblastoma Multiforme	SNX32	0.13	0.05	blup	60	0.09	1.1e-03	4.4	5.3	8.7e-08	0.72	0.07	0.48	FALSE
52	YFS	Blood	CTSW	0.53	0.41	blup	344	0.42	5.5e-149	5.1	-5.3	9.4e-08	-0.66	0.92	0.08	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	CTSW	0.18	0.15	lasso	2	0.14	1.2e-05	5.2	-5.3	1.2e-07	-0.65	0.18	0.65	FALSE
28	GTEx	Lung	CFL1	0.04	0.02	lasso	10	0.01	5.8e-02	5.1	-5.3	1.2e-07	-0.62	0.22	0.43	FALSE
33	GTEx	Pancreas	MAP3K11	0.15	0.16	lasso	3	0.11	1.6e-05	-5.8	-5.3	1.2e-07	-0.34	0.14	0.78	FALSE
63	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CTSW	0.31	0.32	lasso	4	0.34	1.8e-39	5.1	-5.3	1.3e-07	-0.74	0.91	0.09	FALSE
4	GTEx	Adipose Visceral Omentum	CTSW	0.22	0.20	lasso	11	0.19	5.1e-10	5.1	-5.2	1.5e-07	-0.71	0.74	0.26	FALSE
11	GTEx	Artery Tibial	BANF1	0.05	0.05	lasso	5	0.06	3.4e-05	4.8	-5.2	1.5e-07	-0.73	0.28	0.42	FALSE
27	GTEx	Lung	CTSW	0.33	0.20	lasso	8	0.21	3.2e-16	5.1	-5.2	1.7e-07	-0.70	0.87	0.13	FALSE
68	The Cancer Genome Atlas	Lung Adenocarcinoma	CTSW	0.23	0.29	lasso	7	0.29	1.0e-33	5.1	-5.2	1.7e-07	-0.71	0.89	0.11	FALSE
53	YFS	Blood	MAP3K11	0.23	0.25	lasso	10	0.31	3.1e-105	3.5	-5.2	1.8e-07	-0.39	1.00	0.00	FALSE
81	The Cancer Genome Atlas	Thyroid Carcinoma	TSGA10IP	0.04	0.01	blup	44	0.02	1.1e-02	-3.8	-5.2	2.0e-07	-0.63	0.01	0.62	FALSE
3	GTEx	Adipose Subcutaneous	BANF1	0.13	0.05	lasso	8	0.07	1.0e-06	5.1	-5.2	2.2e-07	-0.57	0.92	0.08	FALSE
41	GTEx	Stomach	CTSW	0.18	0.20	lasso	7	0.19	1.7e-09	5.1	-5.2	2.2e-07	-0.71	0.58	0.42	FALSE
73	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CTSW	0.30	0.23	lasso	11	0.24	1.7e-10	5.1	-5.2	2.2e-07	-0.71	0.84	0.15	FALSE
74	The Cancer Genome Atlas	Prostate Adenocarcinoma	CTSW	0.29	0.49	enet	12	0.49	3.4e-58	5.2	-5.2	2.3e-07	-0.70	0.88	0.12	FALSE
79	The Cancer Genome Atlas	Thyroid Carcinoma	CTSW	0.25	0.37	lasso	8	0.37	5.2e-38	5.1	-5.2	2.3e-07	-0.71	0.89	0.11	FALSE
60	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TSGA10IP	0.19	0.01	lasso	5	0.02	2.2e-02	5.0	-5.2	2.4e-07	-0.52	0.07	0.13	FALSE
67	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CTSW	0.63	0.41	lasso	8	0.42	1.2e-21	5.1	-5.2	2.4e-07	-0.68	0.89	0.11	FALSE
72	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CTSW	0.20	0.23	lasso	9	0.23	1.5e-15	5.1	-5.2	2.5e-07	-0.70	0.89	0.11	FALSE
76	The Cancer Genome Atlas	Soft Tissue Sarcoma	CTSW	0.18	0.22	lasso	3	0.22	4.1e-13	5.2	-5.2	2.5e-07	-0.70	0.88	0.12	FALSE
23	GTEx	Esophagus Mucosa	CTSW	0.32	0.19	lasso	6	0.17	1.3e-11	5.1	-5.2	2.6e-07	-0.70	0.87	0.13	FALSE
48	METSIM	Adipose	CTSW	0.13	0.12	lasso	10	0.12	3.9e-17	5.1	-5.1	2.7e-07	-0.69	0.91	0.09	FALSE
32	GTEx	Pancreas	CTSW	0.13	0.11	lasso	3	0.08	4.0e-04	5.1	-5.1	2.8e-07	-0.70	0.21	0.36	FALSE
9	GTEx	Artery Tibial	CTSW	0.12	0.09	enet	22	0.11	1.2e-08	5.1	-5.1	2.9e-07	-0.69	0.81	0.19	FALSE
18	GTEx	Cells Transformed fibroblasts	EIF1AD	0.28	0.20	lasso	8	0.21	1.8e-15	5.1	5.1	2.9e-07	0.61	0.91	0.09	FALSE
64	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CTSW	0.23	0.25	lasso	6	0.25	3.2e-28	5.1	-5.1	3.0e-07	-0.70	0.89	0.11	FALSE
65	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CTSW	0.32	0.26	lasso	1	0.26	4.3e-15	5.1	-5.1	3.1e-07	-0.67	0.89	0.11	FALSE