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chr22:21,798,199-23,002,699

Best TWAS P=1.53e-09 · Best GWAS P=2.73e-09 conditioned to 0.321

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Brain Cerebellum	PPM1F	0.53	0.38	lasso	5	0.44	1.3e-14	5.4	6.0	1.5e-09	0.92	0.00	1.00	TRUE
4	GTEx	Brain Cerebellar Hemisphere	PPM1F	0.60	0.46	lasso	5	0.44	1.1e-12	5.4	5.8	6.6e-09	0.84	0.02	0.98	FALSE
11	GTEx	Lung	LL22NC03-86G7.1	0.19	0.26	enet	14	0.26	5.9e-20	5.1	-5.8	8.4e-09	-0.51	0.28	0.72	FALSE
20	The Cancer Genome Atlas	Thyroid Carcinoma	PPM1F	0.05	0.02	blup	57	0.04	7.5e-05	5.0	-5.7	1.0e-08	-0.59	0.03	0.82	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	YPEL1	0.05	0.01	blup	62	0.04	4.0e-05	4.5	5.6	1.9e-08	0.73	0.05	0.92	FALSE
12	GTEx	Nerve Tibial	PPM1F	0.07	0.02	enet	15	0.02	7.6e-03	4.9	-5.5	4.4e-08	-0.55	0.18	0.36	FALSE
5	GTEx	Brain Cerebellar Hemisphere	LL22NC03-86G7.1	0.48	0.40	enet	32	0.41	1.3e-11	5.1	-5.4	6.2e-08	-0.48	0.42	0.57	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PPM1F	0.03	0.02	blup	57	0.02	2.7e-03	4.7	-5.4	8.2e-08	-0.48	0.04	0.84	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	LL22NC03-86G7.1	0.36	0.40	enet	18	0.24	4.3e-09	5.1	-5.4	8.3e-08	-0.46	0.29	0.71	FALSE
2	GTEx	Adrenal Gland	LL22NC03-86G7.1	0.32	0.34	lasso	3	0.36	1.1e-13	5.1	-5.4	8.6e-08	-0.43	0.43	0.56	FALSE
16	GTEx	Small Intestine Terminal Ileum	LL22NC03-86G7.1	0.39	0.28	lasso	3	0.27	7.6e-07	5.1	-5.3	9.4e-08	-0.47	0.28	0.51	FALSE
13	GTEx	Nerve Tibial	LL22NC03-86G7.1	0.34	0.48	enet	27	0.52	2.0e-42	5.1	-5.3	9.8e-08	-0.48	0.28	0.72	FALSE
9	GTEx	Esophagus Mucosa	LL22NC03-86G7.1	0.21	0.26	lasso	3	0.24	3.3e-16	5.1	-5.3	1.3e-07	-0.45	0.29	0.71	FALSE
17	GTEx	Testis	LL22NC03-86G7.1	0.20	0.11	lasso	8	0.12	9.0e-06	5.1	-5.3	1.4e-07	-0.50	0.41	0.58	FALSE
15	GTEx	Skin Sun Exposed Lower leg	LL22NC03-86G7.1	0.30	0.43	enet	9	0.43	7.8e-39	5.1	-5.2	1.5e-07	-0.43	0.27	0.72	FALSE
3	GTEx	Artery Tibial	LL22NC03-86G7.1	0.23	0.32	enet	24	0.33	9.7e-27	5.1	-5.2	2.2e-07	-0.45	0.28	0.72	FALSE
10	GTEx	Heart Atrial Appendage	LL22NC03-86G7.1	0.44	0.52	enet	8	0.51	7.3e-26	5.0	-5.2	2.2e-07	-0.45	0.31	0.69	FALSE
14	GTEx	Pancreas	LL22NC03-86G7.1	0.35	0.40	lasso	5	0.39	1.4e-17	5.1	-5.2	2.2e-07	-0.43	0.28	0.72	FALSE
7	GTEx	Breast Mammary Tissue	LL22NC03-86G7.1	0.37	0.44	lasso	3	0.42	1.4e-23	5.1	-5.1	2.7e-07	-0.42	0.27	0.73	FALSE
1	GTEx	Adipose Visceral Omentum	LL22NC03-86G7.1	0.33	0.41	enet	22	0.37	2.9e-20	5.1	-5.1	3.1e-07	-0.40	0.30	0.70	FALSE