Best TWAS P=1.53e-09 · Best GWAS P=2.73e-09 conditioned to 0.321
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | LL22NC03-86G7.1 | 0.33 | 0.41 | enet | 22 | 0.37 | 2.9e-20 | 5.1 | -5.1 | 3.1e-07 | -0.40 | 0.30 | 0.70 | FALSE |
| 2 | GTEx | Adrenal Gland | LL22NC03-86G7.1 | 0.32 | 0.34 | lasso | 3 | 0.36 | 1.1e-13 | 5.1 | -5.4 | 8.6e-08 | -0.43 | 0.43 | 0.56 | FALSE |
| 3 | GTEx | Artery Tibial | LL22NC03-86G7.1 | 0.23 | 0.32 | enet | 24 | 0.33 | 9.7e-27 | 5.1 | -5.2 | 2.2e-07 | -0.45 | 0.28 | 0.72 | FALSE |
| 4 | GTEx | Brain Cerebellar Hemisphere | PPM1F | 0.60 | 0.46 | lasso | 5 | 0.44 | 1.1e-12 | 5.4 | 5.8 | 6.6e-09 | 0.84 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Brain Cerebellar Hemisphere | LL22NC03-86G7.1 | 0.48 | 0.40 | enet | 32 | 0.41 | 1.3e-11 | 5.1 | -5.4 | 6.2e-08 | -0.48 | 0.42 | 0.57 | FALSE |
| 6 | GTEx | Brain Cerebellum | PPM1F | 0.53 | 0.38 | lasso | 5 | 0.44 | 1.3e-14 | 5.4 | 6.0 | 1.5e-09 | 0.92 | 0.00 | 1.00 | TRUE |
| 7 | GTEx | Breast Mammary Tissue | LL22NC03-86G7.1 | 0.37 | 0.44 | lasso | 3 | 0.42 | 1.4e-23 | 5.1 | -5.1 | 2.7e-07 | -0.42 | 0.27 | 0.73 | FALSE |
| 8 | GTEx | Esophagus Gastroesophageal Junction | LL22NC03-86G7.1 | 0.36 | 0.40 | enet | 18 | 0.24 | 4.3e-09 | 5.1 | -5.4 | 8.3e-08 | -0.46 | 0.29 | 0.71 | FALSE |
| 9 | GTEx | Esophagus Mucosa | LL22NC03-86G7.1 | 0.21 | 0.26 | lasso | 3 | 0.24 | 3.3e-16 | 5.1 | -5.3 | 1.3e-07 | -0.45 | 0.29 | 0.71 | FALSE |
| 10 | GTEx | Heart Atrial Appendage | LL22NC03-86G7.1 | 0.44 | 0.52 | enet | 8 | 0.51 | 7.3e-26 | 5.0 | -5.2 | 2.2e-07 | -0.45 | 0.31 | 0.69 | FALSE |
| 11 | GTEx | Lung | LL22NC03-86G7.1 | 0.19 | 0.26 | enet | 14 | 0.26 | 5.9e-20 | 5.1 | -5.8 | 8.4e-09 | -0.51 | 0.28 | 0.72 | FALSE |
| 12 | GTEx | Nerve Tibial | PPM1F | 0.07 | 0.02 | enet | 15 | 0.02 | 7.6e-03 | 4.9 | -5.5 | 4.4e-08 | -0.55 | 0.18 | 0.36 | FALSE |
| 13 | GTEx | Nerve Tibial | LL22NC03-86G7.1 | 0.34 | 0.48 | enet | 27 | 0.52 | 2.0e-42 | 5.1 | -5.3 | 9.8e-08 | -0.48 | 0.28 | 0.72 | FALSE |
| 14 | GTEx | Pancreas | LL22NC03-86G7.1 | 0.35 | 0.40 | lasso | 5 | 0.39 | 1.4e-17 | 5.1 | -5.2 | 2.2e-07 | -0.43 | 0.28 | 0.72 | FALSE |
| 15 | GTEx | Skin Sun Exposed Lower leg | LL22NC03-86G7.1 | 0.30 | 0.43 | enet | 9 | 0.43 | 7.8e-39 | 5.1 | -5.2 | 1.5e-07 | -0.43 | 0.27 | 0.72 | FALSE |
| 16 | GTEx | Small Intestine Terminal Ileum | LL22NC03-86G7.1 | 0.39 | 0.28 | lasso | 3 | 0.27 | 7.6e-07 | 5.1 | -5.3 | 9.4e-08 | -0.47 | 0.28 | 0.51 | FALSE |
| 17 | GTEx | Testis | LL22NC03-86G7.1 | 0.20 | 0.11 | lasso | 8 | 0.12 | 9.0e-06 | 5.1 | -5.3 | 1.4e-07 | -0.50 | 0.41 | 0.58 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PPM1F | 0.03 | 0.02 | blup | 57 | 0.02 | 2.7e-03 | 4.7 | -5.4 | 8.2e-08 | -0.48 | 0.04 | 0.84 | FALSE |
| 19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | YPEL1 | 0.05 | 0.01 | blup | 62 | 0.04 | 4.0e-05 | 4.5 | 5.6 | 1.9e-08 | 0.73 | 0.05 | 0.92 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | PPM1F | 0.05 | 0.02 | blup | 57 | 0.04 | 7.5e-05 | 5.0 | -5.7 | 1.0e-08 | -0.59 | 0.03 | 0.82 | FALSE |