Best TWAS P=2.54e-13 · Best GWAS P=4.36e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EP300 | 0.05 | 0.00 | bslmm | 289 | 0.02 | 3.2e-03 | 4.4 | -5.2 | 2.1e-07 | 0.17 | 0.15 | 0.60 | TRUE |
| 2 | GTEx | Brain Frontal Cortex BA9 | SLC25A17 | 0.11 | -0.01 | lasso | 5 | 0.00 | 3.5e-01 | -3.9 | -5.3 | 1.3e-07 | 0.37 | 0.08 | 0.14 | FALSE |
| 3 | GTEx | Testis | ADSL | 0.18 | 0.13 | lasso | 4 | 0.10 | 5.2e-05 | -5.2 | -5.5 | 3.0e-08 | 0.43 | 0.28 | 0.10 | FALSE |
| 4 | YFS | Blood | NHP2L1 | 0.02 | 0.00 | bslmm | 300 | 0.01 | 1.6e-05 | -2.7 | -5.1 | 3.0e-07 | 0.10 | 0.34 | 0.20 | TRUE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TNRC6B | 0.02 | 0.01 | blup | 92 | 0.01 | 2.7e-03 | -3.4 | -5.5 | 3.5e-08 | 0.82 | 0.02 | 0.81 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADSL | 0.04 | 0.03 | enet | 6 | 0.03 | 1.6e-04 | -7.0 | -7.3 | 2.5e-13 | 0.88 | 0.00 | 0.92 | TRUE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADSL | 0.03 | 0.00 | blup | 33 | 0.01 | 8.9e-03 | -7.1 | -6.5 | 9.0e-11 | 0.83 | 0.00 | 0.65 | FALSE |
| 8 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ADSL | 0.06 | 0.02 | lasso | 2 | 0.03 | 6.6e-03 | -7.2 | -7.2 | 6.9e-13 | 0.99 | 0.00 | 0.86 | TRUE |
| 9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ADSL | 0.09 | 0.03 | lasso | 3 | 0.01 | 7.7e-02 | -6.9 | -6.4 | 2.1e-10 | 0.91 | 0.00 | 0.76 | FALSE |
| 10 | The Cancer Genome Atlas | Stomach Adenocarcinoma | MKL1 | 0.05 | 0.01 | blup | 95 | 0.02 | 2.2e-02 | 5.2 | -5.3 | 9.1e-08 | 0.49 | 0.01 | 0.89 | FALSE |