Best TWAS P=2.07e-09 · Best GWAS P=1.02e-11 conditioned to 0.213
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | ECM2 | 0.05 | 0.00 | lasso | 4 | 0.00 | 1.2e-01 | 5.3 | -5.9 | 3.8e-09 | -0.82 | 0.05 | 0.76 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | IPPK | 0.11 | 0.09 | lasso | 8 | 0.07 | 7.8e-06 | 5.6 | 5.7 | 1.5e-08 | 0.95 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Uterus | ZNF484 | 0.23 | 0.05 | lasso | 3 | 0.05 | 3.0e-02 | 5.2 | -6.0 | 2.3e-09 | -0.82 | 0.05 | 0.38 | FALSE |
| 4 | GTEx | Whole Blood | RP11-165J3.6 | 0.10 | 0.07 | lasso | 4 | 0.05 | 1.1e-05 | 5.5 | 5.6 | 2.5e-08 | 0.17 | 0.11 | 0.87 | TRUE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ECM2 | 0.03 | 0.02 | lasso | 5 | 0.02 | 3.9e-05 | 6.3 | -6.0 | 2.1e-09 | -0.90 | 0.01 | 0.99 | TRUE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | BICD2 | 0.06 | 0.02 | blup | 52 | 0.05 | 2.9e-06 | -3.2 | -5.3 | 9.1e-08 | -0.77 | 0.01 | 0.99 | FALSE |