Best TWAS P=1.84e-16 · Best GWAS P=3.78e-34 conditioned to 1.1e-30
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | LOC441454 | 0.05 | 0.01 | lasso | 3 | 0.02 | 1.5e-03 | 5.9 | 5.8 | 6.8e-09 | 0.07 | 0.04 | 0.55 | FALSE |
2 | GTEx | Adipose Subcutaneous | HSD17B3 | 0.21 | 0.01 | enet | 31 | 0.04 | 1.9e-04 | 6.4 | 5.8 | 5.7e-09 | 0.05 | 0.32 | 0.20 | FALSE |
3 | GTEx | Adipose Visceral Omentum | C9orf156 | 0.19 | 0.15 | lasso | 4 | 0.11 | 1.6e-06 | -5.3 | -5.5 | 4.5e-08 | 0.05 | 0.45 | 0.51 | FALSE |
4 | GTEx | Artery Tibial | RP11-435O5.5 | 0.09 | 0.04 | lasso | 2 | 0.02 | 7.3e-03 | 8.2 | -8.0 | 9.6e-16 | -0.03 | 0.24 | 0.09 | TRUE |
5 | GTEx | Brain Cerebellar Hemisphere | C9orf156 | 0.26 | 0.22 | lasso | 2 | 0.14 | 1.9e-04 | -5.3 | -5.3 | 1.1e-07 | 0.05 | 0.13 | 0.51 | FALSE |
6 | GTEx | Brain Cerebellum | C9orf156 | 0.30 | 0.27 | lasso | 7 | 0.24 | 8.1e-08 | -4.9 | -5.2 | 2.1e-07 | 0.04 | 0.54 | 0.40 | FALSE |
7 | GTEx | Brain Cortex | C9orf156 | 0.51 | 0.32 | enet | 11 | 0.29 | 8.1e-09 | -5.3 | -6.0 | 2.5e-09 | 0.05 | 0.50 | 0.47 | FALSE |
8 | GTEx | Brain Frontal Cortex BA9 | C9orf156 | 0.15 | 0.28 | lasso | 1 | 0.26 | 1.1e-07 | -5.3 | -5.3 | 1.1e-07 | 0.05 | 0.33 | 0.39 | FALSE |
9 | GTEx | Breast Mammary Tissue | CDC14B | 0.16 | 0.02 | enet | 21 | 0.02 | 3.7e-02 | 8.0 | -7.0 | 2.0e-12 | -0.06 | 0.06 | 0.86 | FALSE |
10 | GTEx | Breast Mammary Tissue | ERCC6L2 | 0.17 | 0.02 | lasso | 4 | 0.03 | 1.2e-02 | 2.5 | 5.6 | 2.3e-08 | -0.14 | 0.28 | 0.04 | TRUE |
11 | GTEx | Breast Mammary Tissue (Male) | C9orf156 | 0.13 | -0.01 | enet | 1 | -0.01 | 5.6e-01 | -5.3 | -5.3 | 1.1e-07 | 0.05 | 0.05 | 0.07 | FALSE |
12 | GTEx | Breast Mammary Tissue (Female) | C9orf156 | 0.42 | 0.22 | lasso | 10 | 0.23 | 1.5e-07 | -5.3 | -6.7 | 1.8e-11 | 0.02 | 0.06 | 0.87 | FALSE |
13 | GTEx | Cells EBV-transformed lymphocytes | AAED1 | 0.17 | 0.02 | lasso | 3 | 0.04 | 2.4e-02 | 7.8 | 7.3 | 3.9e-13 | 0.06 | 0.05 | 0.44 | FALSE |
14 | GTEx | Cells Transformed fibroblasts | RP11-435O5.5 | 0.14 | 0.04 | lasso | 4 | 0.02 | 7.9e-03 | 5.1 | -5.1 | 2.9e-07 | 0.07 | 0.36 | 0.03 | FALSE |
15 | GTEx | Heart Left Ventricle | C9orf156 | 0.23 | 0.18 | enet | 13 | 0.16 | 9.3e-09 | -5.3 | -5.4 | 5.1e-08 | 0.05 | 0.55 | 0.45 | FALSE |
16 | GTEx | Liver | PTCH1 | 0.25 | 0.06 | enet | 11 | 0.03 | 4.9e-02 | 6.3 | 5.2 | 2.0e-07 | 0.17 | 0.16 | 0.09 | FALSE |
17 | GTEx | Nerve Tibial | HSD17B3 | 0.14 | 0.00 | enet | 20 | 0.00 | 2.4e-01 | 7.7 | 7.6 | 2.8e-14 | 0.11 | 0.09 | 0.34 | FALSE |
18 | GTEx | Nerve Tibial | ZNF367 | 0.10 | 0.05 | lasso | 3 | 0.02 | 7.9e-03 | 8.1 | 7.7 | 1.1e-14 | 0.05 | 0.04 | 0.94 | FALSE |
19 | GTEx | Ovary | C9orf156 | 0.39 | 0.23 | enet | 15 | 0.18 | 3.9e-05 | -5.3 | -6.5 | 8.5e-11 | 0.03 | 0.21 | 0.29 | FALSE |
20 | GTEx | Stomach | C9orf156 | 0.18 | 0.19 | lasso | 1 | 0.18 | 5.9e-09 | -5.3 | -5.3 | 1.1e-07 | 0.05 | 0.54 | 0.44 | FALSE |
21 | GTEx | Testis | HABP4 | 0.19 | 0.22 | lasso | 9 | 0.21 | 1.1e-09 | 7.9 | 7.9 | 3.3e-15 | 0.05 | 0.07 | 0.93 | FALSE |
22 | GTEx | Testis | C9orf156 | 0.39 | 0.40 | enet | 14 | 0.41 | 1.1e-19 | -5.3 | -5.3 | 1.2e-07 | 0.06 | 0.52 | 0.48 | FALSE |
23 | GTEx | Thyroid | CDC14B | 0.15 | 0.10 | lasso | 5 | 0.08 | 5.3e-07 | 7.5 | -7.4 | 1.7e-13 | -0.09 | 0.20 | 0.80 | FALSE |
24 | GTEx | Thyroid | C9orf156 | 0.21 | 0.26 | lasso | 1 | 0.26 | 7.9e-20 | -5.3 | -5.3 | 1.1e-07 | 0.05 | 0.46 | 0.54 | FALSE |
25 | METSIM | Adipose | ANP32B | 0.05 | 0.03 | lasso | 6 | 0.02 | 1.1e-03 | -6.2 | 6.3 | 4.0e-10 | 0.04 | 0.00 | 0.99 | FALSE |
26 | METSIM | Adipose | C9orf156 | 0.15 | 0.17 | lasso | 5 | 0.17 | 4.3e-25 | -5.3 | -5.3 | 1.0e-07 | 0.06 | 0.44 | 0.56 | FALSE |
27 | METSIM | Adipose | ERCC6L2 | 0.06 | 0.01 | bslmm | 569 | 0.03 | 4.6e-05 | 6.9 | -5.2 | 2.2e-07 | 0.20 | 0.16 | 0.11 | TRUE |
28 | YFS | Blood | ANP32B | 0.03 | 0.02 | lasso | 9 | 0.02 | 1.9e-08 | -6.2 | 7.0 | 2.2e-12 | 0.05 | 0.00 | 1.00 | TRUE |
29 | YFS | Blood | HABP4 | 0.08 | 0.09 | enet | 24 | 0.11 | 5.9e-34 | 8.2 | -7.8 | 7.3e-15 | -0.01 | 0.02 | 0.98 | FALSE |
30 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CDC14B | 0.02 | 0.01 | lasso | 1 | 0.01 | 3.0e-03 | 8.0 | -8.0 | 1.2e-15 | -0.05 | 0.03 | 0.59 | FALSE |
31 | The Cancer Genome Atlas | Glioblastoma Multiforme | CDC14B | 0.16 | 0.17 | blup | 41 | 0.19 | 2.6e-06 | 7.8 | -7.3 | 3.9e-13 | -0.06 | 0.05 | 0.92 | FALSE |
32 | The Cancer Genome Atlas | Glioblastoma Multiforme | HABP4 | 0.08 | 0.06 | blup | 44 | 0.05 | 1.6e-02 | 7.5 | -8.2 | 1.8e-16 | -0.04 | 0.03 | 0.49 | TRUE |
33 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HABP4 | 0.02 | 0.02 | blup | 44 | 0.02 | 7.1e-03 | 7.8 | 8.1 | 6.2e-16 | 0.05 | 0.03 | 0.67 | FALSE |
34 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CDC14B | 0.03 | 0.02 | blup | 42 | 0.02 | 2.1e-03 | 7.8 | -8.0 | 9.0e-16 | -0.04 | 0.04 | 0.58 | FALSE |
35 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C9orf156 | 0.18 | 0.23 | lasso | 4 | 0.23 | 1.9e-25 | -5.3 | -5.4 | 5.5e-08 | 0.04 | 0.00 | 1.00 | FALSE |
36 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CDC14B | 0.05 | 0.06 | lasso | 5 | 0.06 | 6.5e-07 | 7.7 | -7.2 | 7.9e-13 | -0.06 | 0.12 | 0.88 | FALSE |
37 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HABP4 | 0.05 | 0.08 | lasso | 5 | 0.08 | 6.9e-09 | 7.6 | -7.7 | 1.4e-14 | -0.06 | 0.11 | 0.89 | FALSE |
38 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C9orf156 | 0.07 | 0.03 | lasso | 2 | 0.03 | 2.1e-04 | -5.3 | -5.2 | 1.6e-07 | 0.04 | 0.00 | 0.99 | FALSE |
39 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PTCH1 | 0.02 | 0.01 | blup | 54 | 0.02 | 1.1e-03 | 7.4 | -7.1 | 1.0e-12 | 0.07 | 0.06 | 0.04 | FALSE |
40 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CDC14B | 0.08 | 0.02 | blup | 41 | 0.04 | 1.0e-03 | 5.9 | -8.1 | 6.6e-16 | 0.00 | 0.02 | 0.60 | FALSE |
41 | The Cancer Genome Atlas | Thyroid Carcinoma | CDC14B | 0.05 | 0.07 | blup | 42 | 0.08 | 4.8e-08 | 8.1 | -7.9 | 3.2e-15 | -0.04 | 0.05 | 0.95 | FALSE |