TWAS hub - ZNF484

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.4120	0.0560	0.0e+00	0.346	0.314	0.347	0.319	0.357	1.1e-43	5.2e-39	9.7e-44	1.2e-39	2.8e-45
2	GTEx	Brain Cerebellum	0.2060	0.0830	3.8e-03	0.015	NA	-0.010	NA	0.009	1.2e-01	NA	8.4e-01	NA	1.7e-01
3	GTEx	Nerve Tibial	0.2817	0.0675	2.5e-07	0.058	NA	0.127	NA	0.126	6.2e-05	NA	3.1e-09	NA	3.3e-09
4	GTEx	Uterus	0.2350	0.1100	6.4e-03	0.052	NA	0.020	NA	0.054	3.3e-02	NA	1.3e-01	NA	3.0e-02
5	NTR	Blood	0.0318	0.0147	2.3e-03	0.009	0.010	0.005	0.011	0.003	3.8e-04	2.4e-04	8.7e-03	1.3e-04	2.8e-02
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0395	0.0234	5.4e-03	0.001	0.012	0.022	NA	0.007	2.7e-01	1.4e-02	1.4e-03	NA	4.5e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Heel T-Score	5.4	43.3	77.3	8.0	6.6	7.8	1.6	8.8	-3.4
Medication: Co-codamol	3.6	4.2	10.9	-1.5	1.9	0.9	2.7	-0.3	3.3
Pain type(s) experienced in last month: Hip pain	3.5	4.4	12.1	2.8	0.3	1.3	0.1	3.5	-2.1
Irritable Bowel Disease (IBD)	3.2	7.5	14.7	3.8	3.0	2.2	2.0	3.6	0.1
Tense / ‘highly strung’	3.2	5.3	17.5	2.5	-0.3	2.1	-0.4	4.2	-2.0
Waist Hip Ratio (WHR)	3.0	13.3	49.0	2.5	7.0	3.0	1.2	0.6	3.7
Hayfever/allergic rhinitis (self-reported)	3.0	4.0	6.8	-1.3	2.2	1.4	2.3	1.9	2.6
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	7.0	1.9	1.9	2.1	0.1	2.6	0.8
Crohns Disease (2017)	2.8	6.2	13.0	3.6	2.5	2.6	1.8	2.9	-0.1
Risk taking	2.8	4.2	8.5	1.7	-1.5	2.3	1.0	2.9	-2.2
Height	2.4	46.0	174.2	3.6	-4.7	-5.3	-13.2	-4.6	-4.0
Pulse wave peak to peak time	2.4	2.8	5.4	2.0	-1.9	0.3	-1.9	0.3	-2.3
Ulcerative Colitis (UC)	2.3	4.3	7.9	2.2	2.6	1.0	2.1	2.8	0.9
Multivitamins +/- minerals	2.2	2.8	6.7	2.5	0.2	2.1	0.2	2.6	-0.1
Heart disease (mother)	2.1	2.5	5.2	2.3	1.5	0.3	-1.1	1.9	-1.8
Blood White Count	2.0	14.6	39.1	-2.4	3.8	1.8	6.2	-2.0	4.7
Vitamin and mineral supplements	2.0	2.7	6.7	-2.0	-0.9	-1.8	-1.2	-2.6	-0.3
Mouth/teeth dental problems	2.0	3.1	11.3	0.2	3.4	-1.3	-0.4	-1.3	1.9
Blood Platelet Count	1.9	22.5	63.7	-1.2	8.0	0.7	6.2	0.6	5.6
Time employed in main current job	1.9	2.1	6.1	-0.4	1.3	1.0	2.5	1.0	1.6
Asthma	1.9	3.7	6.5	1.8	2.5	2.6	0.0	2.3	1.0
Comparative height size at age 10	1.9	10.2	35.7	0.8	-3.0	-3.0	-6.0	-2.2	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.2	7.0	2.6	1.4	2.6	0.4	2.5	-1.8
Sitting height	1.8	12.6	42.8	0.9	-3.9	-1.8	-6.5	-3.0	-2.2
Diabetes (self-reported)	1.8	2.8	7.2	0.4	1.6	1.3	2.2	0.4	2.7
Standing height	1.8	17.8	63.2	1.4	-3.5	-4.0	-8.0	-3.3	-1.9
Number of treatments/medications taken	1.7	3.0	8.6	2.9	1.1	1.9	0.6	1.8	-0.9
Serious illness, injury or assault of a close relative in last 2 years	1.7	2.0	4.2	-1.5	-0.1	-1.9	-1.2	-2.0	0.7
Pulse wave Arterial Stiffness index	1.7	2.0	4.2	-1.8	1.7	-0.2	1.3	-0.4	2.0
Pulse wave reflection index	1.7	2.0	6.6	-0.2	1.1	1.4	2.6	1.2	1.0
Wheeze or whistling in the chest in last year	1.7	3.1	9.0	1.1	0.6	3.0	1.0	2.5	-0.4
Asthma (self-reported)	1.7	3.4	6.2	1.7	2.3	2.5	0.1	2.1	1.0
Alcohol drinker status: Previous	1.7	1.9	5.2	1.5	-1.1	-0.3	-2.3	0.3	-1.7
Chronic bronchitis/emphysema (father)	1.6	1.9	3.3	-0.9	1.8	0.8	1.5	1.3	1.8
Falls in the last year	1.6	2.1	4.9	1.9	0.0	1.7	0.5	2.2	-1.1
Number of live births	1.6	2.3	7.1	1.4	-1.3	-0.3	-1.6	0.4	-2.7
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	4.3	0.5	-1.9	1.2	0.4	1.6	-2.1
Chest pain or discomfort	1.6	2.2	5.7	2.4	-0.6	1.8	-0.3	1.3	-1.6
Illnesses of siblings: Diabetes	1.6	1.9	7.0	0.6	0.5	1.3	0.7	2.7	-1.3
Impedance of arm (right)	1.5	6.8	13.9	2.6	3.7	-0.6	-3.6	-2.1	1.6
Number of full sisters	1.5	1.9	5.6	1.8	0.4	0.8	-1.2	2.4	-0.1
Diabetes diagnosed by doctor	1.5	2.4	5.3	1.4	2.3	1.6	1.2	1.1	1.4
Miserableness	1.5	2.6	7.2	1.7	-1.6	-1.0	0.4	2.7	-1.3
Myopia	1.5	2.2	4.0	-1.6	-0.5	-1.5	-1.8	-2.0	-0.7
Supplements: Zinc	1.4	1.5	3.4	1.9	-0.2	1.3	0.7	1.5	-0.9
Average weekly fortified wine intake	1.4	1.7	4.1	-0.2	-1.5	-2.0	0.2	-1.9	-0.2
Medication: Levothyroxine sodium	1.4	2.3	6.2	-0.0	2.4	-0.2	1.3	-0.6	2.5
Had other major operations	1.4	1.7	3.2	1.2	1.3	1.3	1.5	1.8	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.3	5.9	2.2	1.1	2.4	0.3	1.9	-1.9
Trunk fat-free mass	1.4	7.8	28.9	-0.5	-5.4	-1.8	-2.7	-1.0	-2.5
Trunk predicted mass	1.4	7.7	28.2	-0.3	-5.3	-1.8	-2.8	-1.0	-2.5
Ever had prostate specific antigen (PSA) test	1.4	1.7	3.1	1.3	1.7	1.8	-0.3	1.2	0.9
Primary Biliary Cirrhosis	1.3	1.9	5.6	-0.7	1.2	0.0	1.9	-0.5	2.4
Impedance of leg (left)	1.3	6.4	30.5	1.4	5.5	0.4	-1.3	0.9	1.9
Number of incorrect matches in round	1.3	2.2	4.3	-1.6	-1.1	-2.0	0.8	-2.1	0.6
Ever unenthusiastic/disinterested for a whole week	1.3	1.5	3.0	-1.2	1.5	-0.3	1.7	0.1	1.5
Allergy	1.3	3.0	6.3	-1.4	-1.8	-2.5	-0.5	-2.5	0.1
Impedance of arm (left)	1.3	6.2	12.6	2.8	3.6	-0.6	-3.2	-2.0	1.4
Whole body fat-free mass	1.3	7.3	29.8	-0.3	-5.5	-1.1	-2.4	-0.8	-2.5
Whole body water mass	1.3	7.4	30.4	-0.3	-5.5	-1.1	-2.4	-0.8	-2.5
Average weekly champagne plus white wine intake	1.3	1.7	4.6	1.0	-1.0	0.9	-1.7	-0.1	-2.1
Tinnitus: Yes, now most or all of the time	1.3	1.6	5.1	0.9	0.2	0.0	-2.3	0.1	-1.9
Fractured/broken bones in last 5 years	1.3	1.6	4.6	-1.4	0.4	-2.1	0.7	-1.4	0.8
Impedance of whole body	1.3	6.5	22.7	2.4	4.8	-0.2	-2.6	-0.8	1.8
Schizophrenia (2018)	1.2	2.5	6.9	2.6	0.5	1.1	0.9	2.4	-0.6
Ulcerative Colitis	1.2	1.8	4.4	1.2	2.1	0.7	0.8	1.8	0.4
Ever had hysterectomy (womb removed)	1.2	1.3	3.1	-1.0	0.8	-1.3	-0.3	-1.8	1.2
Leg fat-free mass (left)	1.2	6.5	28.1	0.1	-5.3	-0.5	-2.0	-1.1	-2.3
Leg predicted mass (left)	1.2	6.2	27.1	0.1	-5.2	-0.4	-1.9	-1.0	-2.3
Length of working week for main job	1.2	1.3	3.6	0.1	0.2	1.6	1.9	1.2	0.2
Medication: Ventolin 100micrograms inhaler	1.2	1.6	5.1	0.8	1.0	2.3	-0.6	1.4	-0.7
Hypertension (Self-reported)	1.2	3.3	9.2	3.0	0.8	3.0	-0.0	0.6	-0.8
Leg fat-free mass (right)	1.2	6.4	27.4	-0.0	-5.2	-0.3	-2.2	-1.0	-2.3
Smoking status: Current	1.2	1.9	3.4	-1.8	1.4	-0.3	1.7	-0.1	1.7
Leg predicted mass (right)	1.2	6.4	27.6	-0.0	-5.3	-0.4	-2.2	-1.0	-2.3
Leg fat percentage (left)	1.2	4.4	14.9	0.9	0.6	3.9	2.3	2.3	0.4
Schizophrenia vs Biploar Disorder	1.1	1.4	4.8	-0.4	2.2	-0.8	-0.6	-1.2	0.9
Crohns Disease (2012)	1.1	1.8	5.2	2.3	1.8	0.8	0.8	1.3	-0.1
Neuroticism (2016)	1.1	1.6	4.4	0.8	-0.1	1.1	1.7	2.1	-0.3
Impedance of leg (right)	1.1	5.3	25.9	1.2	5.1	-0.2	-1.2	0.3	1.7
High blood pressure	1.1	3.1	8.2	2.8	0.8	2.9	0.0	0.8	-1.1
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	4.1	1.4	0.2	0.7	0.9	2.0	-1.6
Forced vital capacity (FVC)	1.1	4.4	9.4	-0.7	-3.1	-2.8	-2.5	-1.5	-0.7
Financial difficulties in last 2 years	1.1	1.5	3.1	0.0	1.2	1.0	1.8	1.7	0.6
Mouth/teeth dental problems: Dentures	1.1	1.8	4.1	1.0	-2.0	1.0	-0.7	1.6	-1.3
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	3.4	-0.1	1.2	1.2	1.4	1.8	-0.3
Forced vital capacity (FVC), Best measure	1.1	4.0	10.9	-1.4	-3.3	-2.2	-2.0	-1.5	0.2
Leg fat percentage (right)	1.1	3.8	12.1	0.8	0.5	3.5	2.4	2.1	0.4
Arm fat-free mass (right)	1.1	5.6	24.5	-0.3	-4.9	-0.5	-1.5	0.3	-2.5
Arm predicted mass (right)	1.1	5.6	23.5	-0.2	-4.8	-0.3	-1.6	0.4	-2.6
Overall health rating	1.1	2.4	8.9	0.8	0.6	3.0	1.1	1.8	-0.1
Long-standing illness, disability or infirmity	1.1	1.6	6.1	2.5	0.7	1.3	0.4	0.5	-1.0
Commuting to job workplace: Walk	1.1	1.1	2.3	1.5	0.9	0.8	-0.9	1.2	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.3	0.3	-0.9	-1.8	-1.3	-0.9	-1.0
Medication: Lisinopril	1.1	1.4	5.2	-0.4	2.3	0.0	0.6	-0.0	1.7
Basal metabolic rate	1.1	6.2	26.6	-0.0	-5.2	-0.5	-2.1	-0.6	-2.4
Arm fat-free mass (left)	1.1	5.6	25.1	-0.3	-5.0	-0.2	-1.4	0.3	-2.6
Basal cell carcinoma (self-reported)	1.1	1.3	4.3	1.2	2.1	0.7	-0.6	0.5	-1.0
Arm predicted mass (left)	1.1	5.5	24.1	-0.4	-4.9	-0.3	-1.7	-0.2	-2.3
Bipolar Disorder or Schizophrenia	1.0	2.4	8.0	2.8	-0.6	1.1	0.0	1.8	-1.2
Alzheimer’s Disease (in mother)	1.0	1.2	3.5	-1.4	-0.2	-0.6	-0.5	-1.9	1.0
Alzheimer’s Disease (in father)	1.0	1.1	3.1	1.0	-0.9	-0.6	-1.8	-0.7	-1.0
Major Depression (MDD)	1.0	1.3	2.7	1.5	-1.1	1.0	-0.4	0.5	-1.6
Verbal and Numeric Reasoning (VNR)	1.0	2.5	6.4	-1.6	0.0	-1.3	-1.6	-2.5	1.4
Bipolar Disorder (2011)	1.0	0.9	2.3	1.1	-0.6	-0.1	-1.5	0.9	-1.0
Fasting Glucose	1.0	1.2	3.2	1.8	0.6	1.0	-0.9	1.1	-0.6
Allergy or Eczema	1.0	2.6	5.1	1.6	0.5	2.3	1.2	1.7	-1.8
Respiratory disease	1.0	2.1	5.4	0.8	1.5	2.3	1.5	1.4	0.4
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.6	-1.4	0.1	-0.1	1.6	-1.2	0.8
Supplements: Glucosamine	1.0	1.3	4.5	-2.1	-0.7	-0.9	0.9	-0.4	1.1
Medication: Atenolol	1.0	1.2	5.1	0.1	-1.1	-0.2	-0.9	-2.3	-0.4
Body mass index (BMI)	1.0	4.2	10.7	0.3	-2.2	3.3	2.5	1.6	-0.8
Neuroticism score	1.0	2.1	7.7	2.2	0.3	0.2	0.5	2.8	-0.1
Birth weight of first child	1.0	1.9	2.9	1.1	-1.4	1.3	-1.1	1.5	-1.7
Exposure to tobacco smoke outside home	1.0	1.3	3.8	0.5	-1.9	0.4	-0.1	0.6	-2.0
Medication for pain relief, constipation, heartburn	1.0	1.7	6.2	-1.1	-0.4	-1.0	-1.3	-2.5	0.3
Medication: Blood pressure	1.0	1.8	6.3	2.5	0.4	1.4	0.8	0.2	-1.2
Knee pain experienced in last month	1.0	1.6	4.1	-1.3	-0.2	1.2	2.0	0.6	1.4
Number of self-reported non-cancer illnesses	1.0	1.7	4.8	2.2	0.4	1.7	0.9	1.1	-0.4
Commuting to job workplace: Public transport	1.0	1.2	3.1	-1.6	-0.3	-0.8	-0.1	-1.8	1.1
Intelligence (Savage-Jansen 2018)	0.9	2.7	6.3	-1.6	-0.4	-2.2	-1.2	-2.5	0.8
Breast Cancer	0.9	2.2	5.1	-1.1	-1.6	-2.3	0.3	-2.1	-0.0
BMI	0.9	5.3	13.1	0.5	-2.8	3.6	2.6	1.6	-1.3
Lung FVC	0.9	4.8	12.9	-3.0	-3.6	-2.3	0.9	-0.0	-0.6
Neuroticism	0.9	2.2	6.2	2.5	0.9	0.4	0.3	2.4	-0.3
Maternal smoking around birth	0.9	1.3	2.9	1.5	1.1	1.7	-0.8	0.3	-0.9
Serious illness, injury or assault to yourself	0.9	1.1	2.2	-0.4	-0.2	1.4	1.5	1.3	-0.7
Hip circumference	0.9	3.9	19.1	-0.3	-4.4	0.9	0.1	-0.0	-1.7
Pulse rate	0.9	1.6	5.0	-1.2	2.2	0.4	0.5	-1.2	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	10.9	-1.1	-3.3	-1.3	-1.4	-0.8	-0.0
Loud music exposure frequency	0.9	1.0	3.1	1.2	0.7	0.7	0.8	1.8	0.0
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	4.9	-0.6	1.3	-0.8	0.4	-1.7	2.2
Body fat percentage	0.9	3.5	13.5	2.3	0.2	3.7	0.4	1.4	-0.2
Number of children fathered	0.9	1.0	3.6	-0.4	-1.9	-0.2	-0.9	0.4	-1.1
Mouth/teeth dental problems: Loose teeth	0.9	1.0	1.7	-1.3	-1.3	0.9	-0.8	-1.2	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	3.3	1.8	-0.3	0.2	-1.6	-0.4	-0.8
Arm fat percentage (left)	0.9	3.6	13.4	2.3	-0.5	3.7	1.0	1.3	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.6	0.7	0.9	0.8	0.7	1.6	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	6.0	-1.6	-2.4	-1.5	0.5	-0.3	0.2
Ever taken oral contraceptive pill	0.9	1.0	3.5	-0.1	1.9	0.3	0.3	-0.9	1.3
Mother’s age at death	0.9	1.1	3.4	-0.4	-1.8	-0.7	1.2	0.6	-0.9
Financial situation satisfaction	0.9	1.1	2.6	-0.1	1.6	0.4	1.6	0.4	1.1
Medication: Bendroflumethiazide	0.9	1.4	3.3	0.6	-1.0	1.8	-0.5	1.0	-1.5
Ever depressed for a whole week	0.9	1.1	4.1	-0.7	2.0	-0.5	0.8	0.8	0.6
Worry (Nagel 2018)	0.8	1.7	5.9	1.8	0.2	-0.3	-0.9	2.4	-0.3
Cardiovascular Disease	0.8	2.6	7.1	2.6	0.9	2.7	-0.0	1.1	-0.5
Hypothyroidism (self reported)	0.8	1.7	3.5	-1.1	1.4	-0.4	0.4	-1.8	1.9
Type 2 Diabetes (T2D) (2018)	0.8	1.6	2.9	0.9	1.3	1.7	1.7	0.9	0.6
Medication: Metformin	0.8	1.2	2.7	-0.7	1.3	0.1	1.4	-0.6	1.6
Trunk fat percentage	0.8	3.2	12.0	2.4	0.1	3.5	-0.3	1.1	-0.4
Townsend deprivation index at recruitment	0.8	1.2	3.5	-1.4	0.8	-0.5	0.1	-0.8	1.9
Current tobacco smoking	0.8	1.3	3.1	-1.6	0.7	-0.1	1.8	0.2	1.2
Fed-up feelings	0.8	1.4	3.5	-0.0	-1.1	-0.1	1.6	1.9	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	2.5	0.8	-0.2	0.9	0.7	1.4	-1.6
Taking other prescription medications	0.8	1.2	4.0	2.0	1.6	0.6	0.4	-0.0	0.2
Hayfever, allergic rhinitis or eczema	0.8	1.7	3.0	1.3	0.2	1.7	0.8	1.6	-1.5
Illnesses of siblings	0.8	1.1	2.5	-1.6	0.2	-0.4	0.5	-1.1	1.5
Arm fat percentage (right)	0.8	3.2	12.8	2.2	-0.4	3.6	0.6	1.1	-0.4
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	7.6	-0.6	-2.8	-1.8	-2.0	-0.9	-0.9
Lung cancer (father)	0.8	1.0	2.8	-0.4	0.6	-1.7	-1.6	0.1	0.0
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	4.1	-2.0	-1.1	-0.2	0.3	-1.5	0.0
Headache pain in last month	0.8	1.3	2.7	0.9	0.8	1.1	-0.4	1.6	-1.6
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	5.7	-2.4	-0.7	-0.7	-0.7	-0.5	0.5
Worry too long after embarrassment	0.8	1.4	6.0	2.4	-0.3	0.2	0.4	0.9	-1.1
Health satisfaction	0.8	1.1	2.9	-1.0	0.3	-0.1	1.7	-1.2	0.9
Medication: Ibuprofen	0.8	1.0	1.9	-0.3	1.3	0.8	1.2	1.4	0.2
Illnesses of father: Heart disease	0.8	1.1	4.4	0.3	-1.5	0.0	-0.5	-2.1	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	4.4	-0.8	-2.1	-0.9	0.0	-0.5	-1.2
Hearing aid user	0.8	0.9	2.5	0.1	-0.4	-0.5	-1.6	-0.8	-1.3
Irritability	0.8	1.3	4.5	1.3	-0.7	0.6	-0.2	2.1	-0.7
Vascular/heart problems diagnosed by doctor	0.8	2.1	5.5	-2.3	-0.5	-2.3	0.3	-0.3	1.0
Bipolar Disorder (2018)	0.7	1.1	2.4	1.3	-1.6	0.3	-1.1	-0.1	-1.3
Depressed Affect (Nagel 2018)	0.7	1.5	4.0	1.3	-0.6	-0.9	0.6	2.0	-1.3
Neuroticism (Nagel 2018)	0.7	1.7	5.4	1.7	-0.4	-0.5	0.4	2.3	-1.0
Alzheimer’s Disease (including proxy)	0.7	1.0	3.0	0.1	0.2	-0.5	-1.6	-1.7	0.5
Mean Putamen Volume	0.7	0.8	3.4	0.7	0.9	0.0	-1.9	-0.1	-0.5
Hand grip strength (left)	0.7	1.8	4.5	2.1	-1.5	0.1	-1.9	0.2	-0.7
Hearing difficulty/problems: Yes	0.7	1.1	2.3	1.4	1.0	0.9	0.4	1.5	0.5
Ever used hormone-replacement therapy (HRT)	0.7	0.8	2.3	1.1	-0.1	-0.6	-1.0	0.6	-1.5
Qualifications: CSEs or equivalent	0.7	0.9	2.6	0.7	-1.1	0.9	-0.5	0.1	-1.6
Stomach or abdominal pain in last month	0.7	0.8	3.1	0.4	-0.7	0.4	1.8	1.0	-0.3
Medication: Simvastatin	0.7	1.0	2.8	1.7	-0.6	-1.1	-1.1	-0.4	-0.2
Father’s age at death	0.7	1.0	2.5	-1.1	0.5	0.3	1.6	0.8	1.1
Worrier / anxious feelings	0.7	1.3	2.7	0.6	1.1	1.1	0.9	1.6	1.2
Noisy workplace	0.7	0.8	1.5	0.1	1.2	0.5	1.2	0.8	-1.1
Medication: Cholesterol lowering	0.7	1.2	6.2	2.5	0.8	-0.1	-0.2	0.2	-0.0
Depression (self-reported)	0.7	0.8	2.1	1.5	-0.5	1.3	0.3	0.1	-0.8
Medication: Lansoprazole	0.7	0.8	1.8	0.0	1.0	0.2	1.3	-0.7	1.3
Prospective memory result	0.7	0.9	2.6	-0.3	-1.2	-0.5	-0.9	0.1	-1.6
Arm fat mass (right)	0.7	2.8	8.1	1.7	-2.0	2.8	0.3	0.9	-1.1
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.1	0.8	-1.1	-0.1	-1.0	-0.2	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.8	1.7	-0.3	-0.1	-0.7	-0.3	-1.2
Medication: Seretide 50 evohaler	0.7	0.8	2.3	1.5	1.0	0.5	-0.1	0.9	-0.5
Pulse rate, automated reading	0.7	2.4	5.7	-1.6	1.6	0.8	2.4	-0.7	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.8	1.1	-0.4	1.3	-0.1	0.6	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	4.4	0.1	-1.4	-0.9	-2.1	-0.7	-1.1
Average weekly red wine intake	0.7	1.0	2.1	-0.7	-1.2	-1.2	-0.6	-1.4	0.4
Mood swings	0.7	1.2	5.5	0.8	0.0	-0.4	1.1	2.3	0.1
Friendships satisfaction	0.7	0.9	2.1	-1.1	-1.5	-0.6	-0.1	-1.3	-0.0
Qualifications: nursing, teaching	0.7	1.1	4.9	0.3	-1.1	-0.2	-0.7	0.0	-2.2
Back pain experienced in last month	0.7	1.1	4.3	0.5	0.1	1.0	0.3	2.1	-0.9
Osteoporosis (self-reported)	0.7	0.8	2.2	-0.4	0.2	-1.5	-0.9	-1.3	0.5
Arm fat mass (left)	0.7	2.7	6.6	1.7	-2.1	2.6	0.2	0.9	-1.2
Eye problems/disorders: Glaucoma	0.7	0.8	2.5	1.6	1.2	0.7	0.1	0.7	-0.5
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.5	1.3	-0.0	0.9	-0.5	1.6	-0.3
Number of operations (self-reported)	0.7	1.0	2.0	0.9	0.4	0.5	1.4	1.4	-1.0
Age started oral contraceptive pill	0.7	0.8	1.6	-1.2	-0.5	-0.8	0.4	-1.2	1.0
Unable to work because of sickness or disability	0.7	0.8	1.4	1.0	0.9	0.9	0.5	1.2	0.9
Pain experienced in last month	0.7	1.2	4.5	-0.7	-1.2	-0.5	-0.3	-2.1	0.8
Depression (Nagel 2018)	0.6	0.9	3.0	1.2	0.2	0.2	0.1	1.7	-1.1
Body Mass Index (BMI) (2010)	0.6	0.9	3.5	-0.0	-1.1	1.9	0.3	0.6	-0.4
LDL Cholesterol	0.6	0.9	2.0	1.1	0.8	0.4	-1.4	-0.3	-1.1
Schizophrenia (2014)	0.6	1.4	5.4	2.3	0.6	0.4	-0.3	1.5	-0.5
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.3	0.3	0.3	-1.0	-1.1	-1.5	0.3
Diabetes (mother)	0.6	0.8	1.2	1.1	1.1	1.0	-0.6	1.1	-0.1
Severe depression (siblings)	0.6	0.6	1.7	-0.2	-0.8	-1.3	-0.6	-0.8	0.6
Hand grip strength (right)	0.6	1.6	4.6	1.0	-2.1	-0.0	-1.8	-0.9	-0.4
Age when periods started (menarche)	0.6	1.5	3.0	-1.7	1.0	-0.7	1.2	-0.9	1.5
Trunk fat mass	0.6	2.6	7.2	2.0	-1.4	2.7	-1.0	0.6	-0.9
Hearing difficulty/problems with background noise	0.6	1.0	2.9	1.7	0.5	-0.2	-0.9	1.4	0.2
Had menopause	0.6	0.8	2.4	0.4	-0.6	0.0	0.3	1.6	-1.2
Medication: Ramipril	0.6	0.7	1.8	1.1	0.9	1.4	0.2	-0.5	0.2
Weight	0.6	3.1	12.4	0.9	-3.5	1.4	-1.0	0.2	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	3.0	0.3	-0.8	-0.4	1.1	1.7	-0.7
Shortness of breath walking on level ground	0.6	0.7	2.1	0.1	-0.8	-0.5	-1.4	-0.8	-0.5
Emphysema/chronic bronchitis	0.6	0.7	1.4	1.1	1.2	0.9	-0.3	0.7	0.5
Neck or shoulder pain in last month	0.6	0.8	1.3	0.8	1.1	0.8	-0.7	1.0	-1.0
Migraine (self-reported)	0.6	0.8	2.5	0.8	0.4	1.0	1.6	0.6	-0.1
Mineral and other dietary supplements	0.6	0.8	1.3	-0.3	-1.1	-0.9	-0.6	-1.2	-1.0
Medication: Gliclazide	0.6	0.7	1.4	0.1	1.0	1.1	0.8	1.2	0.0
Ever smoked	0.6	1.1	3.6	0.4	0.4	1.9	0.7	1.3	-0.6
Diastolic blood pressure, automated reading	0.6	1.9	6.5	-0.4	-1.0	2.5	1.6	-0.4	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.3	0.4	1.1	0.9	0.8	0.9	0.4
Leg fat mass (left)	0.6	2.4	9.4	0.8	-1.1	3.1	0.8	1.4	-0.6
HDL Cholesterol	0.5	0.8	2.7	0.5	-0.2	-0.0	-1.6	-0.4	-1.2
Rheumatoid Arthritis	0.5	0.8	3.9	0.2	0.5	-0.4	-2.0	-0.2	0.4
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.4	-1.2	-0.2	0.5	0.9	-0.8	0.2
Smoking Status	0.5	1.2	2.7	-0.6	1.0	-0.5	1.7	-1.0	1.3
Sensitivity / hurt feelings	0.5	0.8	2.9	1.7	0.4	0.5	-0.2	0.8	-0.8
Angina	0.5	0.6	0.8	0.8	-0.8	-0.8	-0.8	-0.5	-0.9
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.0	-0.6	0.3	-1.0	-1.0	-0.7	-0.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.6	0.9	-0.9	0.1	1.3	0.3	-0.6
Waist circumference	0.5	1.9	8.4	0.8	-0.5	2.9	1.2	0.9	0.2
Alcohol usually taken with meals	0.5	0.8	2.4	-0.4	-0.4	-1.2	0.6	-1.6	0.6
Happiness	0.5	0.6	2.5	-0.4	-0.5	-0.5	1.6	-0.6	0.4
Peak expiratory flow (PEF)	0.5	1.1	3.0	0.5	-0.8	-0.9	-1.7	-0.4	-1.4
Number of full brothers	0.5	0.7	1.9	0.3	0.4	0.3	-0.3	1.4	1.3
Eye problems/disorders: None of the above	0.5	0.6	1.6	-0.8	-0.3	-0.8	1.3	0.7	-0.2
Medication: Omeprazole	0.5	0.5	1.0	0.3	0.8	1.0	0.8	0.9	0.2
Whole body fat mass	0.5	2.2	7.4	1.5	-1.5	2.7	-0.4	0.7	-0.8
Leg fat mass (right)	0.5	2.0	7.8	0.7	-1.0	2.8	0.9	1.4	-0.4
Ever had bowel cancer screening	0.5	0.6	1.6	-0.1	-0.2	0.4	-1.3	0.6	-1.2
Alcohol drinker status: Never	0.5	0.6	1.5	-0.4	0.2	-1.2	0.6	-1.2	0.5
Average weekly beer plus cider intake	0.5	0.7	1.9	0.7	1.4	0.9	0.8	0.7	0.1
Commuting to job workplace: Cycle	0.5	0.6	2.8	1.7	-0.6	0.5	-0.4	-0.1	-0.3
Reaction Time	0.4	0.8	2.6	0.6	1.6	-0.2	0.3	1.3	-0.2
Triglycerides	0.4	0.7	2.1	1.1	0.7	1.5	-0.2	0.5	-0.4
Blood Eosinophil Count	0.4	3.2	12.7	-0.2	1.2	1.0	3.6	-0.5	2.0
Lung FEV1/FVC ratio	0.4	2.1	5.6	-0.0	-0.9	1.4	2.4	1.6	-1.0
Diabetes (father)	0.4	0.4	1.8	-0.5	1.3	0.2	0.6	0.2	0.4
Relative age voice broke	0.4	0.7	2.1	1.2	0.0	0.3	0.1	1.5	-0.6
Hair/balding pattern: Pattern 2	0.4	0.5	0.9	-0.5	1.0	-0.6	-0.7	-1.0	0.5
Pain all over the body in last month	0.4	0.4	1.2	0.4	0.0	0.7	-0.3	1.1	-0.6
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.0	0.7	-1.0	0.2	-0.5	-1.4	-1.0
Breastfed as a baby	0.4	0.5	1.1	-1.1	-0.4	-0.9	-0.5	-0.6	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.6	1.3	0.6	0.3	-0.8	0.4	0.5
Hair/balding pattern: Pattern 4	0.4	1.1	5.2	-0.1	-1.0	-0.0	0.0	2.3	-0.4
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.7	0.8	0.0	-1.3	-0.6	0.3	0.1
Glaucoma (self-reported)	0.4	0.5	1.7	0.7	1.3	-0.3	-0.5	-0.1	0.6
Birth weight	0.4	1.0	2.1	0.3	1.4	-0.1	-1.5	0.6	1.1
Comparative body size at age 10	0.4	1.1	2.9	-1.7	-0.6	1.1	0.9	-1.1	0.6
Qualifications: College or University degree	0.4	1.3	3.0	-0.6	1.0	-1.4	-1.3	-1.7	0.3
Medication: Allopurinol	0.4	0.5	0.9	-0.9	0.9	-0.3	0.5	-0.9	0.5
Family relationship satisfaction	0.4	0.4	1.2	-0.3	0.1	-0.8	0.7	-1.1	0.2
Leg pain on walking	0.4	0.5	1.9	0.2	-1.4	-0.5	0.3	0.2	-0.7
Loneliness, isolation	0.4	0.6	1.8	-0.5	-0.3	-1.3	1.0	-0.5	0.0
Eye problems/disorders: Cataract	0.4	0.5	1.5	0.5	-0.4	-0.0	-1.2	-0.8	0.4
Osteoarthritis (self-reported)	0.4	0.5	0.9	0.2	-0.9	0.2	0.6	0.9	-0.9
Guilty feelings	0.4	0.6	1.5	-0.1	-0.8	0.0	1.1	1.2	-0.1
High cholesterol (Self-reported)	0.4	0.7	1.6	0.3	0.4	-1.2	-0.0	-1.1	1.3
Medication: Paracetamol	0.4	0.6	1.2	-0.8	-0.5	-0.6	1.1	0.0	1.1
Medication: Atorvastatin	0.4	0.5	1.8	1.3	-0.0	0.9	0.5	0.5	-0.4
Heart disease (siblings)	0.4	0.5	1.0	0.7	0.2	-1.0	-0.9	0.8	-0.0
Ovarian Cancer	0.3	0.3	1.4	-0.4	-1.2	0.3	0.2	0.5	-0.0
HbA1C	0.3	0.4	0.7	-0.7	-0.6	-0.7	0.8	0.4	0.1
Blood Red Count	0.3	2.8	7.3	-0.0	1.3	2.4	2.7	0.6	1.2
Systolic Blood Pressure	0.3	1.4	3.6	0.6	-0.0	0.4	-1.9	-1.8	-1.1
Average weekly spirits intake	0.3	0.4	0.8	0.9	-0.5	-0.4	-0.2	0.9	-0.5
Systolic blood pressure, automated reading	0.3	1.0	3.2	-0.5	-0.6	1.3	-0.4	-1.8	-0.7
Medication for hormone replacement therapy	0.3	0.3	0.6	-0.8	0.7	-0.3	-0.6	-0.0	-0.4
Qualifications: None of the above	0.3	0.7	3.4	0.4	-0.3	-0.4	0.5	1.9	0.1
Exposure to tobacco smoke at home	0.3	0.3	1.6	-0.0	-1.2	0.3	-0.1	0.2	-0.5
Blood clot in the leg (DVT)	0.3	0.3	0.9	-0.7	-1.0	0.4	0.0	0.2	-0.7
Medication: Paracetamol	0.3	0.4	1.4	-0.4	-0.6	-0.5	1.2	0.3	0.6
Gout (self-reported)	0.3	0.4	1.1	-0.1	0.5	0.7	1.0	-0.1	0.8
Medication: Amlodipine	0.3	0.4	1.1	0.6	1.0	0.6	-0.3	0.7	-0.1
Age at first live birth	0.3	0.5	1.5	-0.4	0.3	-0.4	0.7	-0.9	1.2
Angina (self-reported)	0.3	0.4	0.9	0.9	-0.5	-0.6	-0.6	-0.5	-0.6
Alcohol intake frequency.	0.3	0.6	2.4	1.6	-0.2	0.6	0.7	0.7	-0.1
Had major operations	0.3	0.4	1.2	-0.0	0.6	0.7	1.1	0.1	0.4
Supplements: Vitamin C	0.3	0.4	1.1	0.4	0.4	-0.1	0.9	1.1	0.1
Breast cancer (self-reported)	0.3	0.4	1.0	1.0	0.8	0.7	0.3	-0.0	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.1	-1.0	-1.0	0.0	-0.0	-0.3	-0.3
Age at First Birth	0.2	0.3	0.7	-0.7	-0.6	0.0	0.3	-0.3	0.8
Coronary Artery Disease (CAD)	0.2	0.3	0.9	0.2	0.5	-0.5	0.9	0.6	-0.3
Chronotype (morning person)	0.2	0.4	1.4	0.5	0.8	0.5	-0.3	1.2	0.2
Tanning	0.2	1.9	4.9	-0.1	-2.2	-0.9	-0.7	1.5	-1.7
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	0.5	0.3	-0.2	-0.2	0.7	-0.8
Pack years adult smoking proportion	0.2	0.3	1.1	0.1	-0.0	-0.6	1.1	-0.3	-0.0
High blood pressure (mother)	0.2	0.2	0.7	0.1	-0.2	-0.8	-0.8	-0.2	0.3
Nervous feelings	0.2	0.3	0.7	0.1	0.8	-0.6	-0.8	-0.0	0.5
Heart attack	0.2	0.3	1.0	1.0	-0.0	0.3	-0.3	0.2	-0.6
Alcohol intake versus 10 years previously	0.2	0.3	1.0	1.0	0.1	0.7	0.4	0.5	-0.3
Hair/balding pattern: Pattern 3	0.2	0.2	0.7	0.8	0.3	0.6	0.1	0.1	0.6
Illnesses of mother	0.2	0.3	0.9	-0.9	-0.5	0.2	0.7	-0.3	0.0
High blood pressure (siblings)	0.2	0.2	0.4	0.3	-0.4	0.3	0.5	0.6	-0.6
Mean time to correctly identify matches	0.2	0.5	2.3	0.2	0.4	-0.1	0.4	1.5	-0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	-0.7	0.2	0.3	0.5	0.1	0.4
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.6	0.8	-0.5	0.4	-0.0	-0.4	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.3	-0.6	-0.2	-0.6	0.4	-0.5	-0.2
Smoking status: Previous	0.2	0.2	0.7	0.6	-0.0	0.8	-0.5	-0.3	0.2
Medication for cholesterol	0.2	0.4	1.2	-0.2	-1.1	-0.9	-0.5	-0.2	-0.1
Supplements: Calcium	0.2	0.2	0.6	0.4	0.4	-0.8	-0.2	-0.1	-0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.7	0.8	-0.2	0.3	-0.2	0.2	-0.6
Lupus	0.1	0.2	0.4	-0.0	-0.4	-0.5	0.4	-0.6	0.6
Relative age of first facial hair	0.1	0.2	0.6	-0.2	-0.7	-0.8	-0.3	0.1	-0.2
Fluid intelligence score	0.1	0.2	0.5	0.1	0.2	0.6	-0.7	-0.7	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.7	-0.1	-0.4	0.2	-0.0	0.2	0.8
Suffer from ‘nerves’	0.1	0.2	0.6	-0.4	0.4	-0.3	-0.1	-0.4	0.8
Age at last live birth	0.1	0.1	0.5	-0.2	-0.4	-0.7	-0.1	0.0	-0.2
Medication: Aspirin	0.1	0.1	0.2	0.4	-0.4	-0.1	0.4	0.2	-0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.5	-0.2	0.1	0.3	-0.1	-0.4
Illnesses of father: None of the above (group 1)	0.1	0.2	0.5	0.2	0.6	-0.7	-0.3	0.2	0.1
Wears glasses or contact lenses	0.1	0.2	0.3	0.3	-0.3	-0.1	0.6	-0.4	-0.5
Medication: Blood pressure	0.1	0.2	0.4	0.3	-0.5	0.7	-0.4	-0.6	0.1
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.2	-0.0	-0.5	0.5	-0.1	0.5
Pack years of smoking	0.1	0.2	0.7	0.3	0.1	-0.5	0.8	-0.4	0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.1	0.3	-0.3	0.2	0.1	0.6	0.0	0.2
Past tobacco smoking	0.0	0.1	0.5	0.0	-0.2	-0.7	-0.0	0.2	-0.1
Medication: Aspirin	0.0	0.1	0.2	0.4	0.1	-0.2	0.1	0.3	0.3
Cholesterol lowering medication	0.0	0.1	0.2	0.1	-0.2	0.0	-0.3	-0.4	0.0

Hub : Genes

ZNF484

Models

Trait associations