TWAS hub - ECM2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1600	0.0430	7.6e-11	0.098	0.108	0.109	0.109	0.097	5.3e-12	5.1e-13	3.4e-13	3.8e-13	7.9e-12
2	GTEx	Adipose Subcutaneous	0.0520	0.0270	3.3e-03	0.002	NA	0.001	NA	0.005	1.9e-01	NA	2.6e-01	NA	1.2e-01
3	GTEx	Artery Aorta	0.1110	0.0390	5.7e-05	0.105	NA	0.073	NA	0.090	2.1e-06	NA	7.6e-05	NA	1.1e-05
4	GTEx	Heart Left Ventricle	0.0697	0.0359	6.5e-03	0.046	NA	0.004	NA	0.019	1.7e-03	NA	1.9e-01	NA	3.1e-02
5	GTEx	Liver	0.1630	0.0620	4.4e-05	0.175	NA	0.185	NA	0.181	1.4e-05	NA	7.4e-06	NA	9.0e-06
6	GTEx	Nerve Tibial	0.0844	0.0455	5.0e-03	0.019	NA	-0.003	NA	0.006	1.6e-02	NA	7.2e-01	NA	1.1e-01
7	NTR	Blood	0.0273	0.0119	1.5e-03	0.014	0.008	0.010	0.011	0.011	1.3e-05	7.4e-04	2.2e-04	1.5e-04	1.4e-04
8	TCGA	Breast Invasive Carcinoma	0.0281	0.0167	1.8e-04	0.019	0.019	0.016	NA	0.020	5.8e-05	5.5e-05	2.5e-04	NA	3.9e-05
9	TCGA	Cervical Squamous Cell Carcinoma	0.1790	0.1030	8.4e-03	0.012	0.017	0.071	NA	0.057	7.6e-02	4.6e-02	2.2e-04	NA	8.6e-04
10	TCGA	Brain Lower Grade Glioma	0.2585	0.0845	3.5e-06	-0.002	0.061	0.060	NA	0.001	7.7e-01	1.8e-07	2.2e-07	NA	2.5e-01
11	TCGA	Lung Adenocarcinoma	0.1011	0.0508	2.8e-03	0.038	0.024	0.016	NA	0.036	2.8e-05	6.6e-04	4.3e-03	NA	4.2e-05
12	TCGA	Prostate Adenocarcinoma	0.1884	0.0663	1.2e-07	0.036	0.079	0.085	NA	0.085	1.0e-04	1.2e-08	3.3e-09	NA	3.4e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Waist Hip Ratio (WHR)	5.2	23.3	67.8	-1.7	-2.0	6.5	6.6	6.2	6.1	-3.7	-2.4	1.8	1.2	8.2	4.3
Impedance of arm (right)	5.0	23.2	81.0	-4.6	-5.5	2.2	3.6	9.0	3.7	-5.4	-7.4	3.7	1.7	3.5	0.3
Impedance of arm (left)	4.5	20.8	73.7	-4.6	-5.0	2.2	3.7	8.6	3.4	-5.0	-7.1	3.2	1.3	3.4	0.0
Mouth/teeth dental problems	4.4	6.7	15.9	0.1	0.9	3.3	3.1	2.0	4.0	-2.5	0.2	1.6	2.9	2.9	3.8
Ever depressed for a whole week	4.4	5.4	8.7	2.9	2.8	2.5	2.9	-0.5	2.6	-0.0	2.4	-0.9	3.0	1.6	2.9
Impedance of whole body	4.0	20.4	68.4	-3.5	-3.8	3.3	5.1	8.3	4.3	-5.0	-5.8	2.5	2.1	4.7	1.6
Height	3.8	73.9	201.6	-7.2	-13.3	-7.5	-5.5	10.6	-2.4	-8.0	-14.2	9.4	0.3	-7.7	-6.4
Hayfever/allergic rhinitis (self-reported)	3.7	4.9	11.9	1.8	3.5	2.7	2.2	-1.8	2.2	1.0	3.1	-0.8	1.5	2.2	2.4
Impedance of leg (left)	3.2	15.3	37.0	-0.8	-1.3	4.2	6.1	6.0	4.7	-3.7	-2.7	0.9	2.9	5.2	3.3
Blood Platelet Count	3.1	36.4	81.2	4.9	6.1	9.0	8.6	-0.9	7.3	0.3	6.0	-1.2	3.5	8.2	7.1
Mouth/teeth dental problems: Bleeding gums	2.9	3.7	7.8	0.7	-1.2	-1.8	-2.1	-1.6	-2.6	2.8	0.5	-2.5	-1.8	-1.1	-2.7
Pulse wave peak to peak time	2.9	3.4	7.8	-2.5	-2.5	-2.3	-1.3	2.1	-1.8	-1.7	-2.8	-0.0	-1.0	-0.9	-1.0
Sitting height	2.8	19.5	52.7	-2.9	-7.0	-5.4	-3.5	5.0	-2.7	-2.1	-7.3	1.3	-0.2	-4.4	-5.1
Standing height	2.8	27.5	76.2	-3.9	-8.4	-5.0	-3.7	6.5	-2.0	-3.9	-8.7	4.4	0.6	-5.0	-4.9
Impedance of leg (right)	2.7	13.2	33.4	-1.1	-1.3	3.8	5.8	5.5	4.3	-3.6	-2.6	1.1	2.6	4.7	3.1
Medication: Levothyroxine sodium	2.6	4.4	13.0	-0.8	1.6	2.8	2.4	0.1	2.2	-1.8	1.1	1.1	-0.6	3.5	3.6
Financial situation satisfaction	2.6	3.2	10.5	3.2	1.2	2.0	2.0	-1.6	1.6	1.5	2.8	-0.5	0.8	1.0	0.9
Medication: Co-codamol	2.5	2.9	6.2	1.0	2.2	2.4	1.0	-1.7	1.5	0.9	2.5	-1.1	-0.7	2.3	1.9
Mouth/teeth dental problems: Dentures	2.5	4.2	8.3	-2.4	-1.6	-2.3	-2.6	0.5	-2.4	-0.4	-2.4	1.1	-2.9	-1.6	-2.5
Ever unenthusiastic/disinterested for a whole week	2.4	2.9	6.5	2.3	2.6	2.1	1.5	-1.0	1.9	0.5	2.1	0.1	1.7	1.1	1.7
Comparative height size at age 10	2.4	13.0	35.9	-2.1	-5.9	-3.9	-3.0	4.1	-1.4	-1.8	-6.0	2.1	0.1	-3.6	-4.2
Lung FVC	2.3	11.6	37.3	2.5	2.8	-2.9	-3.4	-6.1	-3.3	3.9	3.8	-1.9	-1.6	-3.9	-2.0
Eye problems/disorders: Diabetes related eye disease	2.3	2.5	6.8	1.3	-0.4	2.3	2.6	1.4	2.4	-0.6	0.0	1.0	1.1	1.9	1.6
Leg fat-free mass (left)	2.3	12.4	33.9	-0.9	-2.9	-5.1	-5.8	-1.5	-4.3	1.4	-1.7	0.5	-2.1	-5.3	-4.6
Leg predicted mass (left)	2.3	12.0	32.7	-0.8	-2.8	-5.0	-5.7	-1.5	-4.2	1.5	-1.6	0.4	-2.0	-5.3	-4.6
Leg fat-free mass (right)	2.3	12.1	33.3	-0.6	-2.8	-5.0	-5.8	-1.3	-4.2	1.5	-1.8	0.4	-1.9	-5.3	-4.7
Leg predicted mass (right)	2.3	12.2	33.9	-0.7	-2.8	-5.0	-5.8	-1.3	-4.2	1.5	-1.7	0.4	-1.9	-5.3	-4.7
Whole body fat-free mass	2.2	12.6	34.1	-0.1	-2.5	-5.3	-5.8	-2.1	-4.4	1.6	-1.0	0.5	-1.9	-5.8	-4.3
Whole body water mass	2.2	12.7	34.3	-0.1	-2.4	-5.3	-5.8	-2.1	-4.4	1.6	-1.0	0.4	-1.9	-5.9	-4.4
Bipolar Disorder (2018)	2.1	3.4	8.8	-2.9	-2.3	-1.5	-1.1	2.0	-1.1	-1.6	-3.0	1.3	-1.6	-0.9	-1.2
Blood White Count	2.1	15.2	44.8	0.4	4.2	5.0	4.9	-1.6	3.1	1.5	4.4	-3.7	-0.1	6.7	4.8
Trunk fat-free mass	2.1	11.8	35.9	0.2	-2.3	-5.2	-5.6	-2.2	-4.3	1.4	-0.8	0.7	-1.5	-6.0	-3.8
Hip circumference	2.1	8.9	18.4	0.5	-0.3	-4.0	-4.3	-3.1	-3.8	2.7	0.6	-1.6	-2.5	-4.2	-3.8
Glaucoma (self-reported)	2.1	2.5	6.8	-1.6	-2.2	1.1	1.8	2.6	1.3	-1.5	-2.0	0.5	-0.3	1.8	0.2
Mouth/teeth dental problems: Loose teeth	2.1	2.5	6.7	-0.2	-2.5	-1.8	-1.0	1.4	-1.5	0.5	-2.2	-0.8	0.6	-1.7	-2.6
Basal metabolic rate	2.1	11.4	29.6	-0.1	-2.5	-5.0	-5.4	-1.8	-4.2	1.7	-1.1	0.1	-1.8	-5.3	-4.3
Pulse wave Arterial Stiffness index	2.0	2.3	5.3	2.3	1.9	1.9	1.1	-1.5	1.7	1.5	2.1	0.3	1.2	0.6	0.7
Trunk predicted mass	2.0	11.6	34.9	0.1	-2.3	-5.2	-5.5	-2.1	-4.2	1.3	-0.9	0.7	-1.5	-5.9	-3.8
Arm fat-free mass (right)	2.0	10.3	27.3	1.0	-1.3	-4.6	-5.0	-2.9	-4.0	2.3	0.3	-0.5	-1.5	-5.2	-3.7
Arm predicted mass (right)	2.0	10.1	28.3	1.0	-1.3	-4.6	-5.0	-2.8	-3.9	2.1	0.1	-0.4	-1.5	-5.3	-3.8
Medication: Lisinopril	2.0	2.5	6.9	0.5	0.7	2.4	2.1	1.0	2.6	-0.5	0.3	1.4	1.5	2.1	1.6
Arm fat-free mass (left)	2.0	10.1	26.0	0.5	-1.6	-4.7	-5.1	-2.5	-4.1	2.1	-0.1	-0.6	-1.7	-5.0	-3.8
Irritable Bowel Disease (IBD)	1.9	4.4	16.6	-0.5	0.4	3.4	3.2	1.3	2.2	-0.7	0.4	0.1	0.4	4.1	2.6
Number of children fathered	1.9	2.1	4.6	-1.7	-1.0	-2.1	-2.0	-0.9	-2.0	-0.3	-0.6	0.8	-2.0	-1.7	-0.7
Mother’s age at death	1.9	2.4	8.3	-0.3	1.5	-0.9	-1.7	-2.9	-1.8	0.8	2.1	-0.7	-2.3	-0.9	0.5
Arm predicted mass (left)	1.9	9.9	25.6	0.4	-1.8	-4.7	-5.1	-2.3	-4.0	2.0	-0.4	-0.6	-1.6	-4.9	-3.9
Schizophrenia vs Biploar Disorder	1.8	2.4	5.5	1.0	-0.2	1.7	2.3	1.3	1.9	-1.8	0.3	-0.2	1.9	1.3	2.2
Alzheimer’s Disease (in father)	1.8	2.0	5.2	-1.4	-1.9	-1.4	-1.0	1.5	-0.9	-0.7	-2.3	-0.3	-1.3	-1.0	-2.0
Ulcerative Colitis (UC)	1.8	3.4	11.4	0.5	1.1	3.1	2.5	-0.2	2.0	0.1	1.6	-0.0	0.1	3.4	2.3
Smoking status: Current	1.8	2.9	6.7	2.3	1.5	1.8	0.7	-1.5	0.9	2.0	2.6	-2.1	0.6	1.9	1.0
Basal cell carcinoma (self-reported)	1.8	2.2	6.5	2.3	-0.2	1.6	2.5	1.0	1.8	0.0	0.6	-0.4	2.0	1.3	1.0
Crohns Disease (2017)	1.7	3.7	13.0	-1.1	-0.1	2.8	3.2	2.0	1.8	-0.9	-0.5	0.2	0.5	3.6	2.0
Pulse rate	1.7	2.9	6.3	2.2	1.1	1.8	2.4	1.1	2.2	0.4	0.5	-1.5	2.5	2.1	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.4	14.8	-0.8	-0.6	-3.6	-3.7	-1.4	-3.1	0.4	-0.9	0.4	-1.7	-3.9	-2.7
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	6.1	2.5	0.6	1.0	1.5	-0.2	1.0	1.8	1.3	-2.0	1.3	0.4	-0.5
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	5.7	1.7	0.7	-1.7	-0.9	-2.4	-1.7	2.2	1.5	-1.0	-1.0	-2.0	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.5	10.4	-0.3	2.1	-2.0	-2.2	-3.2	-2.5	0.9	1.7	-0.3	-2.1	-1.9	-0.2
Eye problems/disorders: Glaucoma	1.7	2.0	4.3	-1.7	-1.8	0.9	1.9	2.1	0.7	-0.7	-1.7	-0.6	-1.1	1.9	-0.0
Number of full sisters	1.6	1.9	6.1	-0.6	-1.9	0.0	-0.7	2.5	0.6	-1.4	-2.5	1.8	0.1	0.7	-0.4
Osteoarthritis (self-reported)	1.6	2.0	8.0	1.3	1.2	-0.5	-1.3	-2.8	-1.0	1.6	2.2	-0.0	-1.1	-1.1	-0.3
Commuting to job workplace: Cycle	1.6	1.9	4.8	-1.9	-1.8	-1.0	-0.8	1.2	-1.4	-1.0	-2.2	0.3	-1.8	-0.8	-1.1
Crohns Disease (2012)	1.5	2.4	5.5	-1.6	0.1	1.8	2.3	1.7	1.6	-1.8	-0.7	1.3	0.5	1.7	1.8
Mean Putamen Volume	1.5	1.7	5.7	-0.4	-0.9	-0.1	0.3	2.4	1.0	-1.9	-2.1	1.4	1.7	-0.1	0.6
Hand grip strength (right)	1.5	4.0	10.4	-1.7	-2.6	-2.3	-2.0	1.8	-1.6	-0.3	-3.2	1.1	-1.1	-1.9	-2.7
Time employed in main current job	1.5	1.8	6.8	0.3	1.4	2.2	1.5	0.2	1.5	0.3	0.8	0.4	0.2	2.6	1.4
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	6.7	0.7	1.5	1.4	0.7	-1.4	0.6	-0.8	2.5	0.1	0.1	1.3	2.6
Medication: Cholesterol lowering	1.5	2.3	4.0	-2.0	-1.8	0.8	0.5	1.7	0.6	-2.0	-1.4	1.4	-1.5	2.0	1.5
Forced vital capacity (FVC), Best measure	1.5	5.4	16.1	-0.9	-1.0	-3.6	-3.3	-0.7	-2.7	-0.0	-1.7	1.5	-1.2	-4.0	-2.9
Eye problems/disorders: None of the above	1.5	1.8	4.2	1.5	1.5	0.1	-1.1	-2.0	-0.6	2.0	1.8	-1.0	-0.0	-1.2	-1.0
Illnesses of father: Heart disease	1.5	2.1	5.3	-2.3	-1.0	-1.6	-0.9	1.5	-1.6	-0.6	-2.2	-1.4	-1.2	0.1	-1.2
Diabetes diagnosed by doctor	1.5	2.4	9.0	0.3	0.6	2.2	2.2	0.8	1.9	-0.7	0.5	0.1	0.0	3.0	2.2
Ever taken oral contraceptive pill	1.5	1.6	4.5	1.0	0.1	1.8	2.1	0.8	1.9	-0.6	0.2	0.6	1.1	1.6	1.3
Risk taking	1.5	2.2	5.3	0.1	0.2	-1.6	-1.4	-1.9	-2.3	1.6	1.1	-2.1	-1.8	-0.7	-0.9
Primary Biliary Cirrhosis	1.4	2.0	5.9	-0.3	2.4	1.6	0.4	-0.9	0.8	-0.4	1.6	-0.1	-1.5	1.9	2.4
Diabetes (self-reported)	1.4	2.1	11.2	-0.7	1.0	2.0	1.4	0.3	1.4	-0.1	0.6	-0.2	-1.1	3.3	1.8
Number of live births	1.4	2.0	4.9	-0.5	-1.8	-2.0	-1.3	1.1	-1.7	0.3	-1.8	0.5	-0.1	-1.6	-2.2
Pulse wave reflection index	1.4	1.7	4.7	0.9	1.8	1.8	-0.3	-2.1	1.0	1.3	2.2	0.3	-0.9	0.8	0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	5.8	-1.1	-2.4	-2.1	-1.9	1.5	-1.7	-0.6	-2.4	0.4	-0.1	-2.3	-2.0
Bipolar Disorder or Schizophrenia	1.3	3.1	11.5	-2.7	-3.4	-0.4	-1.2	1.4	-1.1	-1.1	-2.2	1.6	-2.1	0.2	-0.7
Bipolar Disorder (2011)	1.3	1.3	5.0	-0.1	-2.2	-0.8	-0.7	1.7	-0.7	-0.3	-2.0	0.0	0.6	-0.7	-1.2
Current tobacco smoking	1.3	2.1	5.1	1.5	1.3	1.2	0.2	-1.6	0.1	2.1	2.3	-2.2	0.1	1.5	0.5
Stomach or abdominal pain in last month	1.3	1.6	5.3	-0.6	0.8	-0.3	-0.8	-1.9	-1.5	1.0	1.4	-1.4	-2.3	0.7	0.5
Chronic bronchitis/emphysema (father)	1.3	1.6	3.4	1.2	1.6	1.8	0.9	-0.9	1.5	0.7	1.7	0.7	1.0	1.2	1.3
Body mass index (BMI)	1.3	5.6	15.9	1.1	1.4	-1.5	-2.5	-4.0	-2.1	3.5	2.6	-2.3	-2.4	-1.1	-1.9
Weight	1.3	6.4	15.6	-0.5	-2.4	-3.5	-3.9	-0.9	-2.8	1.7	-1.3	-0.3	-1.9	-3.2	-3.9
Medication: Ibuprofen	1.3	1.5	4.1	0.7	1.5	1.6	1.1	-0.8	1.1	-0.6	1.9	0.5	0.5	1.3	2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	5.8	-0.5	-1.7	-0.7	-0.0	2.3	-0.1	-0.1	-2.4	0.0	0.2	0.1	-1.7
Pulse rate, automated reading	1.3	4.1	7.3	2.6	2.3	2.0	1.8	-1.4	1.6	2.5	2.7	-2.2	1.4	2.0	0.8
LDL Cholesterol	1.2	1.8	7.4	0.7	-1.1	0.5	1.7	2.7	0.9	-1.1	-1.9	-0.0	2.0	0.2	-0.3
Neuroticism (2016)	1.2	1.7	6.7	1.3	1.4	0.3	-0.1	-2.4	-0.8	1.2	2.6	-0.9	-0.7	-0.1	0.7
Heel T-Score	1.2	9.8	35.6	0.9	-0.6	5.0	4.5	2.6	5.0	0.6	-0.0	-1.1	0.2	6.0	1.5
Hand grip strength (left)	1.2	3.3	8.8	-1.7	-2.5	-1.7	-1.7	1.9	-1.3	-0.8	-3.0	1.4	-1.3	-1.3	-2.1
Medication: Metformin	1.2	1.7	4.2	1.4	0.9	1.8	1.8	0.2	1.6	0.6	1.1	-0.9	0.9	2.0	1.1
Handedness (chirality/laterality): Left-handed	1.2	1.4	5.0	-2.2	-0.4	-0.2	-0.8	0.9	-0.1	-2.1	-1.1	1.9	-0.5	-0.2	1.0
Average weekly champagne plus white wine intake	1.2	1.6	3.9	1.3	-0.7	-2.0	-0.8	1.0	-1.3	0.1	-1.4	-0.9	1.0	-1.9	-1.7
Miserableness	1.2	2.1	6.0	-0.2	-0.3	-1.2	-1.0	-2.5	-2.3	0.9	1.2	-0.3	-2.4	-1.4	-1.1
Guilty feelings	1.2	1.8	8.0	0.0	1.1	-0.3	-1.7	-2.8	-0.5	-0.0	2.1	0.7	-1.5	-1.1	1.0
Fractured/broken bones in last 5 years	1.2	1.5	4.4	1.7	0.6	1.0	1.6	-0.7	0.8	2.1	1.2	-1.6	0.8	0.6	-0.9
Ovarian Cancer	1.1	1.5	8.0	0.6	-0.4	-0.9	-0.3	0.5	-1.0	2.0	-1.0	-0.9	0.0	-0.9	-2.8
Fasting Glucose	1.1	1.3	3.5	-1.6	-1.8	0.1	-0.1	1.8	0.6	-1.2	-1.9	1.1	-0.0	0.6	-0.2
Ulcerative Colitis	1.1	1.6	5.9	0.3	0.9	1.9	1.5	0.3	1.4	-0.2	0.8	-0.7	0.0	2.4	1.6
BMI	1.1	6.4	17.1	-0.0	1.6	-2.1	-3.4	-4.1	-2.7	2.9	2.2	-2.0	-3.5	-1.2	-1.9
Serious illness, injury or assault to yourself	1.1	1.3	3.0	0.5	1.0	-0.3	-1.2	-1.7	-0.9	1.3	1.5	-1.6	-1.6	0.1	0.2
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	7.2	-1.7	-1.0	-0.4	-1.0	-0.3	-1.3	0.1	0.0	-0.7	-2.7	0.6	-0.3
Forced vital capacity (FVC)	1.1	4.3	13.4	-0.3	-1.3	-3.3	-2.6	-0.1	-2.1	0.3	-1.8	0.9	-0.3	-3.7	-3.1
Medication: Simvastatin	1.1	1.7	6.3	-2.5	-1.7	-0.7	-0.7	0.8	-0.5	-1.1	-1.6	1.3	-1.7	0.7	0.2
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	4.9	0.2	0.7	-0.5	-1.3	-2.2	-1.4	1.6	1.9	-1.4	-2.0	0.2	-0.6
Depression (self-reported)	1.1	1.3	5.5	-0.5	-1.2	-0.4	-0.8	0.1	-0.6	1.5	-0.2	-2.3	-1.4	0.8	-1.6
Medication: Lansoprazole	1.1	1.3	2.5	0.5	1.6	1.5	1.5	-0.9	1.2	0.5	1.5	1.0	0.2	1.0	1.1
Exposure to tobacco smoke at home	1.1	1.2	3.0	1.2	0.0	-1.3	-0.8	-0.5	-1.1	1.7	0.1	-1.6	-0.1	-1.1	-1.7
Birth weight	1.1	2.4	6.6	-0.5	-1.1	0.9	0.6	2.2	1.5	-1.9	-1.5	2.2	2.6	-0.0	1.1
Exposure to tobacco smoke outside home	1.1	1.4	3.0	0.2	0.2	-1.7	-1.7	-1.2	-1.6	1.7	0.5	-1.1	-0.7	-0.7	-1.2
Medication for pain relief, constipation, heartburn	1.1	1.9	6.0	0.4	-1.3	-0.7	0.3	2.3	0.1	-0.1	-2.4	-0.1	1.9	-1.0	-2.0
Medication: Gliclazide	1.1	1.2	4.0	0.4	1.2	1.2	0.9	-0.2	0.9	-0.1	1.2	-0.4	0.6	2.0	1.9
Number of operations (self-reported)	1.1	1.6	4.8	1.4	0.9	0.5	-0.5	-2.0	-0.4	1.8	2.2	-1.6	-0.6	0.6	0.4
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.0	-0.3	-0.5	1.3	0.8	1.2	1.6	-1.4	-0.2	0.6	1.1	1.7	1.5
Type 2 Diabetes (T2D) (2012)	1.0	1.2	7.5	-0.6	-0.1	-0.2	1.0	0.6	-0.8	1.0	-0.3	-2.7	-0.9	1.5	-0.2
Systolic Blood Pressure	1.0	5.1	17.6	-2.8	-3.7	-0.9	0.6	4.2	0.1	-1.8	-3.8	-0.6	0.4	1.4	-1.1
Hearing difficulty/problems with background noise	1.0	1.7	5.4	-1.9	-1.3	0.2	-0.2	1.5	0.5	-1.7	-1.7	2.3	-0.5	0.5	-0.2
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	11.0	-0.3	-1.0	-3.1	-2.7	-0.5	-2.3	0.2	-1.2	0.1	-0.4	-3.3	-2.3
Happiness	1.0	1.2	3.7	0.4	1.9	-0.1	-0.1	-1.3	-1.1	1.2	1.1	-1.9	-1.1	0.2	-0.2
Length of working week for main job	1.0	1.1	3.4	0.4	1.0	0.8	0.4	-1.8	0.4	1.4	1.7	-0.4	-1.2	1.1	0.3
Health satisfaction	1.0	1.3	4.8	0.9	2.2	0.5	0.7	-1.1	-0.1	1.5	1.3	-1.9	-0.3	0.7	-0.3
Qualifications: nursing, teaching	1.0	1.6	3.7	1.4	0.1	-1.2	-1.0	-0.6	-1.1	1.6	0.3	-1.9	1.1	-1.7	-1.6
Alcohol drinker status: Previous	1.0	1.1	2.1	-0.8	-1.4	-1.4	-1.0	0.7	-0.9	-0.8	-1.3	0.4	-1.0	-1.2	-1.0
Lupus	0.9	1.3	7.8	-1.2	-0.2	-0.4	-1.1	-1.8	-1.0	-0.1	0.9	0.3	-2.8	-0.1	0.7
Diabetes (father)	0.9	1.1	3.2	0.0	0.1	1.1	1.0	0.6	1.2	-1.2	0.4	-0.8	1.3	1.2	1.8
Average weekly fortified wine intake	0.9	1.1	5.5	-2.4	-0.3	-1.1	-1.2	-0.4	-1.1	-0.4	-0.5	0.7	-1.5	-0.6	-0.1
Taking other prescription medications	0.9	1.4	4.3	-0.8	-0.9	1.4	0.6	0.5	1.3	-1.2	-0.1	1.2	-1.2	2.1	1.7
Medication: Atenolol	0.9	1.1	3.6	-1.9	-0.9	-1.3	-0.4	0.7	-1.0	-0.6	-1.4	-0.4	-1.5	0.0	-0.3
Had menopause	0.9	1.1	3.2	1.2	0.9	-0.2	-1.1	-1.8	-0.5	1.7	1.3	-0.0	-0.1	-0.8	-0.8
Financial difficulties in last 2 years	0.9	1.2	3.2	0.9	1.3	1.5	1.1	-0.5	1.2	0.8	1.4	-0.4	0.3	1.8	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	5.9	1.1	0.4	-0.0	1.7	0.4	0.9	-0.1	-0.0	0.1	2.4	-1.0	0.1
Prospective memory result	0.9	1.2	2.7	1.7	0.2	-1.4	-1.2	-1.4	-1.1	0.7	0.9	-0.8	-0.1	-1.5	-0.4
Medication: Paracetamol	0.9	1.6	4.0	-0.1	1.4	-0.2	-0.5	-2.0	-1.2	0.7	2.0	-1.3	-1.7	0.4	1.3
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	4.3	-0.2	0.3	1.6	2.1	0.6	1.5	-1.3	0.2	0.4	0.1	2.0	2.1
Medication: Amlodipine	0.9	1.3	3.1	-1.8	-1.2	0.7	0.4	1.4	1.0	-1.4	-1.0	1.0	0.1	1.2	1.2
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.2	-1.1	-1.2	-1.3	-1.0	0.8	-1.1	-0.4	-1.5	0.5	-0.3	-1.2	-1.3
Comparative body size at age 10	0.9	2.4	9.0	3.0	1.5	-0.4	-0.2	-2.1	-0.4	2.4	1.8	-0.9	0.8	-1.0	-1.0
Knee pain experienced in last month	0.9	1.5	3.5	1.5	1.6	0.2	-0.2	-1.9	-0.7	1.5	1.8	-1.6	-0.9	0.3	-0.1
Ever had bowel cancer screening	0.9	1.0	2.7	-0.6	-1.6	-0.6	-1.6	-0.3	-0.1	-1.4	0.0	1.6	-0.3	-1.0	0.9
Eye problems/disorders: Cataract	0.9	1.1	3.6	-1.9	-1.3	-0.9	-1.0	0.2	-0.5	-1.4	-1.0	1.4	-0.9	0.0	0.3
Mineral and other dietary supplements	0.9	1.2	2.9	-1.0	-1.5	-1.2	-1.1	0.7	-1.1	-0.3	-1.4	0.3	-0.6	-1.1	-1.7
Medication: Paracetamol	0.9	1.4	3.9	-0.0	1.4	-0.0	-0.4	-1.9	-0.6	1.0	1.8	-1.1	-2.0	0.6	0.8
Alzheimer’s Disease (including proxy)	0.8	1.2	4.3	-0.6	-0.9	-0.4	1.1	2.1	0.1	-0.9	-2.0	-1.1	0.0	-0.2	-1.1
Major Depression (MDD)	0.8	1.0	2.9	-1.4	-0.9	-1.4	-1.1	-0.0	-1.7	-0.4	-0.8	0.6	-1.1	-0.9	-0.4
HbA1C	0.8	0.9	3.5	0.4	1.9	-0.3	-0.1	-1.7	-0.2	0.1	1.2	0.9	-0.7	-0.8	0.6
Schizophrenia (2014)	0.8	1.7	8.6	-1.3	-2.9	0.7	-0.0	1.4	-0.1	-1.3	-1.2	1.6	-0.9	0.9	0.7
Lung FEV1/FVC ratio	0.8	4.1	11.8	1.8	1.3	-0.3	-1.0	-3.2	-1.4	2.7	3.2	-3.4	-1.1	-0.0	0.2
Supplements: Glucosamine	0.8	1.1	4.0	0.7	1.7	-0.1	-0.1	-2.0	-0.4	0.6	1.9	-0.2	0.5	-0.7	1.0
High blood pressure (mother)	0.8	1.1	4.5	-1.4	-0.2	-0.2	0.8	1.4	0.3	-2.1	-1.1	1.0	0.8	0.0	1.0
Number of incorrect matches in round	0.8	1.4	4.4	0.4	1.6	-0.4	-0.9	-2.1	-0.5	1.5	1.6	-1.0	-1.4	-0.4	-0.4
Father’s age at death	0.8	1.1	2.8	1.4	1.4	1.0	1.3	-1.3	0.2	0.9	1.7	-0.3	0.7	-0.2	0.7
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	4.5	1.6	1.4	-0.8	-0.1	-0.7	-0.4	0.7	0.6	-0.7	2.1	-2.1	-0.8
Number of full brothers	0.8	1.0	2.8	-1.4	-1.7	0.6	-0.1	0.7	0.6	-1.0	-0.7	1.4	-0.5	1.2	0.5
Medication: Blood pressure	0.8	1.4	4.9	-2.1	-1.0	0.4	0.1	0.7	0.0	-0.7	-0.8	0.1	-2.2	1.9	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	4.1	-2.0	-0.0	-0.7	-0.8	-0.3	-0.8	-1.3	-0.3	0.4	-1.9	-0.4	0.4
Medication: Aspirin	0.8	1.1	4.7	-1.8	-0.0	-0.5	-1.1	-1.2	-0.6	-0.6	0.5	0.3	-2.2	0.1	1.2
Hypertension (Self-reported)	0.8	2.2	4.9	-2.2	-2.2	0.4	0.2	2.2	0.4	-1.1	-2.2	1.1	-1.3	1.7	-0.4
Friendships satisfaction	0.8	1.0	3.6	0.1	0.6	-1.2	-0.8	-0.4	-1.4	1.4	-0.1	-1.9	-0.1	-0.6	-1.4
Triglycerides	0.7	1.1	4.7	-0.1	-0.2	0.7	2.2	1.9	0.7	-0.6	-1.3	-1.0	0.2	1.2	0.3
Hypothyroidism (self reported)	0.7	1.6	5.8	-0.2	1.0	1.3	1.7	-0.1	1.2	-1.2	0.8	-0.3	-0.1	2.0	2.4
Type 2 Diabetes (T2D) (2018)	0.7	1.2	7.3	-0.0	0.1	1.5	1.1	0.3	1.1	0.0	0.6	-0.6	-0.7	2.7	1.3
Number of treatments/medications taken	0.7	1.2	4.0	-1.6	-0.7	0.9	-0.2	0.0	0.8	-0.7	-0.2	1.2	-2.0	1.6	1.1
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.5	-1.1	-1.1	0.2	0.1	0.7	1.1	-1.6	-0.7	1.4	-0.1	0.8	1.2
Ever had hysterectomy (womb removed)	0.7	0.7	2.6	-0.0	-0.2	0.9	0.9	1.3	1.1	-0.8	-0.6	-0.0	1.6	0.7	0.6
Medication for hormone replacement therapy	0.7	0.8	3.3	1.8	-0.4	0.4	0.3	0.1	0.8	-0.4	0.5	1.0	1.8	-0.6	0.6
Maternal smoking around birth	0.7	1.1	4.4	-0.9	-1.2	0.4	0.5	1.8	0.2	-1.0	-1.0	-0.5	-0.3	2.1	0.7
Fed-up feelings	0.7	1.2	5.0	0.0	0.7	-0.8	-0.9	-2.2	-1.6	0.6	1.6	-0.3	-1.1	-1.0	-0.1
Trunk fat mass	0.7	3.0	9.3	-1.2	-2.9	-1.8	-1.7	1.3	-1.0	0.5	-2.5	0.0	-1.2	-1.0	-3.0
Alcohol usually taken with meals	0.7	1.2	3.1	-1.6	1.3	-0.2	-0.2	-1.0	-0.6	-1.8	0.5	1.1	-1.5	-0.4	1.4
Had other major operations	0.7	0.8	2.1	0.2	1.0	1.1	0.2	-1.3	0.2	0.7	1.4	-0.7	-1.0	1.0	0.9
Asthma	0.7	1.4	5.0	0.5	-0.5	2.1	1.4	0.9	2.2	0.0	-0.1	0.5	-0.2	1.9	0.6
Lung cancer (father)	0.7	0.8	3.9	0.6	1.2	0.3	0.1	-0.5	0.8	-0.6	0.5	2.0	1.2	-0.7	0.8
Arm fat mass (right)	0.7	2.7	8.4	-0.5	-1.4	-1.9	-2.3	-0.7	-1.7	1.8	-0.7	-0.9	-1.9	-1.2	-2.9
Blood clot in the leg (DVT)	0.7	0.9	3.2	0.1	0.4	-1.2	-0.5	-0.4	-0.7	1.4	-0.1	-1.7	-0.6	-0.2	-1.8
Shortness of breath walking on level ground	0.7	0.8	2.0	-0.9	-1.4	-1.1	-0.4	0.8	-0.8	-0.1	-1.3	-0.3	0.3	-1.0	-1.1
Emphysema/chronic bronchitis	0.7	0.8	3.1	0.1	-0.9	0.8	0.6	1.8	1.0	-0.3	-1.3	0.4	1.0	0.8	-0.1
Commuting to job workplace: Walk	0.7	0.7	3.6	0.9	-0.7	0.5	0.8	1.9	0.7	-0.1	-1.2	-0.5	0.8	0.5	-0.3
Asthma (self-reported)	0.7	1.3	4.7	0.2	-0.6	2.0	1.3	1.0	2.2	-0.1	-0.3	0.7	-0.3	1.9	0.5
Medication: Aspirin	0.7	1.0	3.8	-1.4	0.1	-0.1	-0.8	-1.1	-0.2	-0.8	0.5	0.5	-2.0	0.3	1.6
Illnesses of father: None of the above (group 1)	0.7	0.9	4.0	-0.8	0.1	0.8	1.1	-0.3	0.6	-1.2	0.4	2.0	-0.8	0.3	1.3
Arm fat mass (left)	0.7	2.9	8.5	-0.5	-1.3	-2.0	-2.4	-1.0	-1.8	1.8	-0.5	-0.9	-2.0	-1.3	-2.9
Tinnitus: Yes, now most or all of the time	0.7	0.8	3.9	-0.4	-2.0	-0.8	-0.4	1.3	-0.2	-0.6	-1.3	0.0	0.5	-0.6	-0.6
Myopia	0.7	1.0	4.7	1.6	0.0	-0.9	-0.9	-0.4	-0.1	0.3	0.9	-0.6	2.2	-1.2	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.0	0.4	0.4	1.3	-0.6	-1.1	1.4	0.5	1.2	1.4	-0.5	1.0	0.4
Reaction Time	0.6	1.1	2.0	0.4	0.3	1.4	1.1	0.9	1.2	-1.0	0.4	-0.6	1.3	1.4	1.3
Body Mass Index (BMI) (2010)	0.6	0.9	2.1	0.7	0.2	-1.1	-0.9	-1.2	-1.1	1.1	0.4	-0.8	-0.1	-1.5	-1.0
Smoking Status	0.6	1.3	4.0	0.5	1.0	1.5	-0.5	-1.3	0.6	0.6	1.7	-0.6	-1.3	2.0	1.1
Vitamin and mineral supplements	0.6	0.8	1.9	-0.5	-0.9	-0.9	0.2	1.4	-0.9	-1.2	-1.3	-0.4	1.1	-0.9	-0.1
Diabetes (mother)	0.6	0.8	3.2	1.8	0.2	0.7	1.1	-0.2	1.3	0.3	0.9	0.0	1.4	0.1	0.3
Qualifications: CSEs or equivalent	0.6	0.9	1.8	-0.2	-1.3	-1.3	-1.2	0.5	-1.1	0.1	-0.7	-1.0	0.3	-0.8	-1.4
High blood pressure	0.6	1.7	4.3	-1.9	-1.8	0.4	0.3	2.1	0.4	-1.1	-2.0	1.0	-0.9	1.5	-0.3
Neuroticism score	0.6	1.3	5.8	-0.8	-0.2	0.4	-0.4	-1.2	0.1	-1.2	0.6	2.1	-2.4	0.0	0.9
Peak expiratory flow (PEF)	0.6	1.3	3.5	-0.7	-1.9	-1.4	-1.5	1.2	-1.1	-0.9	-1.6	-0.0	-0.1	-1.1	-0.9
Loud music exposure frequency	0.6	0.7	1.9	0.9	0.4	1.0	-0.2	-0.8	1.0	-0.4	1.1	1.4	-0.3	0.4	1.0
Neck or shoulder pain in last month	0.6	0.8	3.1	1.8	0.0	0.6	0.8	0.1	0.9	0.8	0.6	-1.3	1.0	0.9	-0.0
Medication: Omeprazole	0.6	0.7	1.8	0.3	0.1	1.1	-0.6	-0.8	1.1	0.4	0.8	1.4	-0.8	1.1	0.2
Medication: Seretide 50 evohaler	0.6	0.7	1.8	-1.3	0.4	0.8	0.2	0.2	1.0	-0.9	-0.2	1.2	-1.0	0.8	0.6
Heart disease (mother)	0.6	0.8	2.6	1.1	0.2	0.7	1.6	0.6	1.1	0.4	-0.3	0.8	1.5	0.5	-0.1
Alcohol intake frequency.	0.6	1.3	6.7	-0.6	-0.1	0.1	0.2	-0.7	-0.7	1.4	0.6	-1.4	-2.6	1.6	-0.7
Chest pain or discomfort	0.6	0.9	2.4	-1.4	-1.6	-0.7	-0.6	0.2	-0.7	0.3	-0.9	-0.2	-1.5	0.0	-1.2
Family relationship satisfaction	0.6	0.7	2.1	1.4	1.3	0.4	1.1	-0.5	0.2	0.1	1.1	-0.7	0.7	0.4	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.8	2.4	-0.0	1.3	0.0	0.0	-1.6	-0.2	0.1	1.5	0.1	-0.8	0.4	1.4
Illnesses of siblings: Diabetes	0.6	0.8	3.1	1.8	0.3	0.5	0.1	-1.3	0.1	0.7	1.4	1.2	0.2	-0.5	-0.1
Smoking status: Previous	0.6	0.9	2.3	-0.4	-1.5	-0.2	-1.0	1.0	0.4	-0.8	-1.4	1.5	-0.7	-0.0	-0.7
Long-standing illness, disability or infirmity	0.6	0.9	4.3	-1.3	-0.8	0.5	-0.3	0.3	0.5	-0.3	0.0	-0.3	-1.3	2.1	1.3
Hearing aid user	0.6	0.7	3.0	-0.5	-1.7	-0.9	-0.2	1.1	-0.7	-0.8	-1.2	-0.3	-0.0	-0.3	-0.5
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.6	1.2	0.9	0.2	0.1	-1.6	0.1	0.6	1.5	0.6	-0.7	-0.4	-0.2
Medication: Bendroflumethiazide	0.6	0.9	3.3	0.5	-1.1	-1.1	-0.5	0.3	-0.8	1.0	-0.7	-1.2	0.3	-0.6	-1.8
Medication: Atorvastatin	0.6	0.7	3.3	-1.3	-1.1	0.2	-0.9	-0.1	-0.2	-0.1	-0.1	-0.2	-1.8	1.3	0.3
Diastolic blood pressure, automated reading	0.6	1.8	8.2	0.3	0.8	-0.9	-0.2	-0.9	-1.2	2.4	0.6	-2.9	-0.4	0.3	-1.7
Vascular/heart problems diagnosed by doctor	0.6	1.6	4.5	2.1	1.6	-0.0	0.2	-1.9	-0.1	1.4	2.0	-1.0	0.9	-1.2	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.6	-0.0	0.5	-1.1	-0.4	-0.6	-0.7	1.3	0.1	-1.6	-0.6	-0.2	-1.5
Schizophrenia (2018)	0.5	1.1	6.2	-1.0	-2.5	0.7	-0.6	0.2	-0.5	-0.1	-0.4	1.1	-1.5	0.9	0.1
Coronary Artery Disease (CAD)	0.5	0.6	1.7	0.7	0.8	0.6	1.3	-0.3	0.1	-0.3	1.0	0.2	1.3	-0.1	1.0
HDL Cholesterol	0.5	0.9	2.5	-0.4	-1.6	-1.0	-1.2	0.9	-0.2	-1.4	-1.1	0.8	0.7	-0.8	0.4
Rheumatoid Arthritis	0.5	0.6	1.9	1.0	-1.0	0.2	-0.3	0.7	0.7	-1.1	-0.5	0.9	1.4	-0.5	0.5
Blood Eosinophil Count	0.5	3.5	6.8	-0.0	2.1	1.7	0.8	-2.2	0.6	2.1	2.4	-2.4	-2.6	2.6	0.5
Cardiovascular Disease	0.5	1.6	4.4	-1.8	-2.1	0.6	-0.3	1.3	0.3	-1.0	-1.4	1.4	-1.3	1.5	0.3
Respiratory disease	0.5	1.0	2.8	0.6	0.4	1.4	1.3	-0.1	0.9	1.4	0.6	-1.5	-0.5	1.7	-0.1
Sensitivity / hurt feelings	0.5	0.9	4.4	-2.1	-0.4	-0.2	-0.3	0.1	-0.4	-1.5	-0.8	1.1	-1.3	-0.3	0.0
Hearing difficulty/problems: Yes	0.5	0.8	3.0	-1.0	0.1	1.0	0.6	0.8	1.0	-0.4	-0.4	1.7	0.1	1.4	0.4
Ever used hormone-replacement therapy (HRT)	0.5	0.6	3.3	1.8	-0.7	-0.1	0.4	-0.2	0.3	0.7	0.4	0.1	1.1	-1.0	-0.6
Angina	0.5	0.7	2.4	-0.9	-0.3	-1.1	-1.5	-0.4	-1.0	-0.1	-0.5	0.9	-0.9	-0.9	-0.4
Trunk fat percentage	0.5	2.1	6.2	-1.4	-2.5	-0.5	-0.1	2.1	0.0	0.1	-2.5	-0.3	-0.9	0.6	-2.3
Townsend deprivation index at recruitment	0.5	0.7	2.7	-0.5	0.2	1.0	0.5	-0.4	0.9	-0.7	0.9	0.9	0.2	1.3	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	2.3	0.9	0.1	-0.5	-0.1	-1.0	-1.0	0.8	0.8	-1.5	-0.5	-0.7	-0.4
Relative age voice broke	0.5	0.8	3.8	-1.2	-0.0	-0.1	0.4	-0.1	-0.5	-1.4	-0.2	2.0	0.3	-0.8	0.9
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.4	0.5	0.6	0.4	0.8	-0.9	0.1	1.0	1.2	-1.0	-0.5	0.3	0.3
Hair/balding pattern: Pattern 2	0.5	0.6	1.6	0.1	-0.8	0.7	0.9	1.2	1.1	-0.1	-0.5	-0.5	0.9	1.0	0.2
Illnesses of siblings	0.5	0.7	2.9	-1.7	0.5	-0.0	-0.8	-0.2	-0.2	-1.6	0.1	0.6	-0.5	-0.1	1.2
Worrier / anxious feelings	0.5	0.9	1.9	-0.9	0.6	1.2	0.6	-0.5	1.3	-0.3	0.6	0.8	-1.3	1.4	0.9
Noisy workplace	0.5	0.7	3.1	0.4	0.7	1.1	-0.0	-0.6	0.5	-0.9	1.2	0.3	0.2	0.1	1.8
Birth weight of first child	0.5	0.8	2.2	-0.4	-0.7	-1.4	-1.0	0.6	-0.9	-0.3	-1.2	-0.3	0.1	-1.5	-1.2
Wheeze or whistling in the chest in last year	0.5	0.9	3.2	-0.1	-0.8	0.4	-0.9	-0.3	0.1	1.2	0.4	-1.5	-1.8	1.4	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.7	-1.3	-1.1	-0.5	-0.5	0.3	-0.2	-1.0	-0.8	1.2	-0.9	-0.3	-0.1
Qualifications: College or University degree	0.5	1.4	6.7	0.9	-0.4	0.8	0.7	1.6	1.6	-1.2	-0.7	1.0	2.6	-0.2	0.7
Whole body fat mass	0.5	2.2	7.9	-0.5	-2.0	-1.7	-1.8	0.4	-1.1	1.1	-1.5	-0.7	-1.2	-1.1	-2.8
Leg pain on walking	0.5	0.6	2.0	-0.7	0.2	-1.1	-1.1	-0.9	-1.0	-0.2	-0.0	0.5	-0.9	-1.4	-0.4
Medication for cholesterol	0.5	0.7	2.2	-1.5	0.0	-1.0	-1.1	0.1	-1.0	-0.9	-0.7	-0.1	-1.2	-0.7	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.4	-0.9	-0.7	-1.2	-1.1	0.6	-0.8	-0.7	-1.0	-0.0	0.3	-0.9	-0.5
Commuting to job workplace: Public transport	0.5	0.6	2.6	-0.8	1.6	-0.2	0.2	-0.1	0.0	-1.4	0.2	-0.4	0.1	-0.0	1.4
Irritability	0.5	0.8	3.4	-0.1	0.1	-1.0	-1.0	-1.3	-1.4	-0.5	0.5	0.1	-1.8	-0.6	0.3
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.4	0.3	1.3	-0.3	0.4	0.5	0.9	-1.3	-0.7	1.2	1.6	-0.7	1.1
Allergy or Eczema	0.4	1.0	7.1	-0.4	0.2	0.4	0.0	-0.4	-0.4	1.0	0.6	-2.7	-1.2	1.3	0.2
Neuroticism	0.4	0.9	3.1	-0.9	0.2	0.8	0.4	-0.4	0.6	-1.4	0.2	1.8	-1.6	0.3	0.7
Systolic blood pressure, automated reading	0.4	1.1	2.7	-0.9	-1.4	-0.9	0.4	1.6	-0.4	0.1	-1.6	-1.3	0.3	0.3	-1.5
Age when periods started (menarche)	0.4	0.9	3.5	0.6	1.1	0.9	0.7	-1.4	0.2	0.5	1.9	-0.8	-0.0	0.5	1.1
Multivitamins +/- minerals	0.4	0.5	2.1	-0.8	-0.4	-0.1	-1.3	-0.9	0.1	0.6	0.2	0.5	-1.4	0.1	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.7	1.3	0.1	0.3	0.4	-0.9	-0.1	0.7	1.3	-1.2	0.2	-0.6	-0.5
Medication: Ramipril	0.4	0.5	1.2	-0.4	-0.1	0.6	0.7	0.7	0.5	-0.7	-0.4	0.7	-0.9	1.1	0.9
Falls in the last year	0.4	0.5	1.3	1.1	0.1	0.2	-0.0	-0.7	-0.1	1.2	1.0	-0.7	-0.8	0.9	0.1
Qualifications: A levels/AS levels or equivalent	0.4	1.0	2.2	-1.4	-0.2	-1.1	-1.1	0.9	-0.8	-0.8	-1.5	-0.6	-0.4	-1.2	-1.1
Illnesses of mother	0.4	0.5	2.2	-0.0	-0.7	-0.3	-1.5	-0.6	-1.1	0.3	0.3	-0.7	-0.9	-0.4	-0.0
Hair/balding pattern: Pattern 4	0.4	0.9	2.6	0.3	-0.2	-0.9	-1.4	-1.4	-0.9	0.1	0.5	1.6	-0.1	-1.3	-0.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.4	-0.6	0.9	-1.2	-0.9	-0.8	-1.0	-0.1	-0.1	-0.2	-0.6	-1.2	-0.3
Headache pain in last month	0.4	0.7	4.1	1.5	-0.8	-0.1	0.4	0.2	-0.5	0.4	0.3	-2.0	0.3	-0.0	0.0
High blood pressure (siblings)	0.4	0.6	2.4	1.6	-0.0	0.1	0.3	-0.3	0.0	1.5	0.4	-1.2	0.6	0.1	-0.7
Leg fat percentage (right)	0.4	1.4	3.4	0.6	1.1	0.6	0.4	-1.5	0.2	1.7	1.5	-1.8	-1.3	1.3	-0.2
Worry too long after embarrassment	0.4	0.7	3.0	-1.5	-0.0	-0.2	-0.7	-0.4	-0.4	-0.7	-0.2	1.3	-1.7	-0.5	-0.2
Angina (self-reported)	0.4	0.5	1.7	-0.9	-0.1	-0.7	-1.3	-0.3	-0.7	-0.3	-0.4	1.1	-0.9	-0.5	-0.1
Leg fat mass (right)	0.4	1.4	3.6	0.7	-0.1	-1.0	-1.3	-1.4	-0.9	1.9	0.7	-1.4	-1.2	-0.6	-1.6
Osteoporosis (self-reported)	0.4	0.5	1.6	-0.2	-0.2	0.3	1.2	1.3	0.8	-0.7	-0.9	-0.5	-0.1	0.6	0.5
Number of self-reported non-cancer illnesses	0.4	0.7	2.7	-1.1	-1.2	0.4	-0.4	0.1	0.0	0.4	-0.3	-0.1	-1.6	1.6	-0.4
High cholesterol (Self-reported)	0.4	0.6	1.6	-1.2	-0.7	0.8	0.2	0.2	0.6	-0.7	-0.2	0.8	-0.6	1.2	1.2
Leg fat percentage (left)	0.4	1.4	4.1	0.8	1.1	0.7	0.3	-1.2	0.3	1.8	1.4	-2.0	-1.2	1.4	-0.3
Unable to work because of sickness or disability	0.4	0.5	2.7	0.0	-0.7	1.1	0.4	0.1	0.5	0.2	0.5	-0.5	0.1	1.6	0.9
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.5	0.4	0.7	-0.6	-0.9	-1.0	-0.4	1.2	0.5	-0.5	-1.0	-0.2	-0.7
Leg fat mass (left)	0.4	1.6	3.8	0.6	-0.3	-1.2	-1.5	-1.1	-1.0	1.9	0.4	-1.6	-1.3	-0.6	-1.9
Neuroticism (Nagel 2018)	0.3	0.7	3.3	-0.9	-0.1	-0.1	-0.4	-1.3	-0.6	-0.7	0.6	1.1	-1.8	-0.5	0.1
Alzheimer’s Disease (in mother)	0.3	0.4	1.2	-0.1	0.3	-0.2	1.0	1.0	0.0	-0.3	-0.9	-1.1	0.2	-0.2	-0.7
Breast Cancer	0.3	0.6	1.4	-0.6	1.2	-1.0	-0.6	-0.9	-1.0	0.3	0.4	-0.7	-0.8	-0.9	-0.5
Tanning	0.3	3.5	12.2	-0.4	0.7	-2.0	-3.5	-2.5	-2.3	-0.2	0.9	0.8	-1.7	-3.1	-0.3
Average weekly spirits intake	0.3	0.4	1.0	0.7	-0.5	-0.5	-0.4	-0.9	-0.5	1.0	0.3	-0.1	-0.1	-0.9	-0.9
Frequency of depressed mood in last 2 weeks	0.3	0.5	2.6	1.0	-0.6	-0.1	-0.2	-0.1	0.0	0.9	0.2	-1.6	-0.3	-0.1	-0.9
Supplements: Zinc	0.3	0.3	0.9	0.0	-0.1	-0.4	-0.9	-0.4	-0.9	0.8	-0.1	-0.4	-0.7	-0.1	-0.5
Pack years adult smoking proportion	0.3	0.5	2.8	-0.3	-0.1	0.3	-0.2	0.0	-0.1	0.8	0.2	-1.4	-0.6	1.7	0.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.3	0.0	-0.7	-0.2	-1.1	-0.1	-0.3	-0.0	0.1	-0.6	-0.9	0.4	0.5
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.8	-1.1	0.4	0.1	-0.8	-0.6	-0.4	0.3	0.5	-1.7	-1.3	1.0	0.3
Nervous feelings	0.3	0.6	2.2	-0.2	-0.6	0.3	1.1	0.3	1.1	-1.1	-0.4	1.5	-0.5	-0.0	0.4
Qualifications: None of the above	0.3	0.6	2.4	-1.0	-0.8	-0.1	-1.1	-0.4	-0.6	0.4	0.3	0.1	-1.6	1.0	-0.2
Heart attack	0.3	0.4	1.2	0.3	0.6	-0.5	-0.8	-0.8	-0.3	1.1	0.3	-0.4	-0.8	-0.3	-0.7
Allergy	0.3	0.7	2.9	0.1	-0.5	-1.3	-1.0	-0.6	-1.3	0.0	0.0	0.8	0.1	-1.7	-0.6
Fluid intelligence score	0.3	0.7	2.8	-1.0	0.5	0.0	0.1	0.9	0.5	-1.7	-1.0	0.9	0.6	-0.3	0.8
Arm fat percentage (right)	0.3	1.1	3.8	-1.1	-1.2	-0.6	-0.6	0.4	-0.5	1.0	-1.1	-0.6	-1.6	0.5	-1.9
Tense / ‘highly strung’	0.3	0.6	2.3	-0.1	-1.0	-0.6	-1.5	-0.5	-0.9	-0.4	0.2	0.2	-1.3	-0.4	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.6	-0.1	-0.9	0.5	1.3	1.2	0.7	-0.7	-0.7	-0.1	0.6	0.6	-0.1
Gout (self-reported)	0.3	0.4	1.3	0.2	0.2	0.5	-1.1	-1.0	-0.1	0.4	0.9	0.1	-0.8	-0.0	0.3
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.5	-0.5	-0.5	0.3	0.6	1.2	0.8	-0.6	-1.0	0.4	0.3	0.4	0.3
Body fat percentage	0.3	1.1	3.5	-0.8	-1.6	-0.2	-0.1	1.1	0.0	0.7	-1.4	-0.8	-1.1	0.8	-1.9
Migraine (self-reported)	0.3	0.3	1.4	0.4	0.0	0.5	0.2	-0.9	0.0	0.0	1.2	-0.7	-0.2	0.3	0.9
Had major operations	0.3	0.3	1.3	-0.7	0.2	0.5	-0.1	-0.5	-0.1	-0.2	0.6	0.1	-0.7	1.0	1.1
Supplements: Vitamin C	0.3	0.4	1.3	-0.2	1.1	0.4	0.8	-0.8	0.3	0.0	0.8	0.1	-0.2	0.8	0.8
Arm fat percentage (left)	0.3	1.3	4.7	-1.0	-1.1	-0.6	-0.8	0.1	-0.6	1.3	-0.9	-0.8	-2.0	0.5	-2.2
Average weekly red wine intake	0.3	0.4	1.5	-0.5	-0.7	-0.8	-0.4	0.5	-0.4	0.1	-1.0	-0.3	-0.0	-0.9	-1.2
Mood swings	0.3	0.5	2.3	0.1	0.2	0.3	-0.2	-1.3	-0.5	-0.2	1.0	0.8	-1.5	0.0	0.6
Back pain experienced in last month	0.3	0.5	1.0	0.5	0.3	-0.3	-0.9	-1.0	-0.4	0.9	0.9	-1.0	-0.7	-0.1	-0.4
Breast cancer (self-reported)	0.3	0.3	1.0	-0.3	-0.7	0.4	-0.5	0.3	0.1	0.4	-0.5	-0.1	-0.8	0.7	-1.0
Medication: Blood pressure	0.3	0.6	2.1	-0.7	-0.9	-0.6	-0.2	0.9	-0.1	-0.1	-1.4	0.9	-0.1	-0.5	-1.4
Alcohol drinker status: Never	0.3	0.3	1.4	0.1	0.5	0.4	0.2	-0.6	0.2	-0.2	0.9	0.6	-0.2	0.8	1.2
Average weekly beer plus cider intake	0.3	0.5	1.7	-0.3	-0.2	1.1	0.7	0.4	0.9	-0.1	0.2	0.8	0.3	1.3	0.8
Age started oral contraceptive pill	0.3	0.3	1.8	0.3	1.4	-0.3	-0.0	-0.1	-0.3	0.5	-0.4	0.2	0.0	-0.8	-0.9
Supplements: Calcium	0.3	0.3	1.2	0.3	-0.2	0.5	0.2	0.8	0.5	-1.0	-0.1	-0.3	0.5	0.2	1.1
Heart disease (siblings)	0.3	0.4	1.2	0.7	-1.1	0.6	0.1	0.0	1.0	0.7	0.1	0.6	0.1	0.6	-0.1
Pack years of smoking	0.3	0.5	2.7	-0.9	-0.4	0.3	-0.2	0.4	0.1	0.3	-0.2	-0.9	-0.9	1.7	0.5
Depressed Affect (Nagel 2018)	0.2	0.5	2.0	-0.5	-0.2	-0.1	-0.1	-1.2	-0.9	-0.3	0.7	0.6	-1.4	-0.4	-0.1
Worry (Nagel 2018)	0.2	0.5	1.7	-0.6	-0.6	0.3	0.3	-0.2	0.6	-0.8	0.0	1.3	-1.3	0.3	0.4
Age at First Birth	0.2	0.2	0.9	0.4	0.1	-0.0	-0.2	-0.6	0.0	0.5	0.3	0.8	-0.1	-1.0	-0.5
Blood Red Count	0.2	1.5	7.0	-0.7	1.4	1.5	0.4	-0.6	0.9	1.0	1.0	-0.5	-1.2	2.6	0.9
Chronotype (morning person)	0.2	0.5	2.2	0.0	-0.8	0.1	1.0	0.8	-0.0	0.5	-0.6	-1.5	-0.7	0.8	-0.6
Relative age of first facial hair	0.2	0.4	1.1	-0.7	-0.6	-0.7	0.1	-0.3	-0.9	-0.4	-0.2	0.7	-0.3	-1.0	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.4	0.1	0.3	0.8	1.2	-0.2	0.9	0.6	0.5	-0.4	-0.1	0.9	0.2
Waist circumference	0.2	0.6	2.1	0.1	-0.5	-0.3	-0.7	-0.6	-0.4	1.5	0.2	-0.8	-1.2	0.2	-1.4
Past tobacco smoking	0.2	0.4	1.3	-0.4	1.2	-0.1	1.1	-0.6	-0.5	0.5	0.7	-0.8	0.1	-0.0	0.3
Pain all over the body in last month	0.2	0.2	0.6	-0.4	-0.2	-0.2	-0.8	0.3	-0.2	-0.4	-0.2	0.5	0.5	0.1	0.6
Breastfed as a baby	0.2	0.3	0.7	-0.6	0.3	-0.6	-0.7	-0.7	-0.2	-0.2	0.2	0.5	-0.5	-0.8	0.2
Age at first live birth	0.2	0.3	1.6	-0.5	0.3	0.5	0.2	-0.2	0.4	-0.6	0.1	1.3	-0.2	-0.2	0.7
Medication: Allopurinol	0.2	0.3	0.9	0.2	-0.3	1.0	-0.5	-0.2	0.4	-0.0	0.8	-0.4	0.2	0.7	0.9
Overall health rating	0.2	0.4	1.4	-0.2	0.1	0.2	-0.0	-0.5	-0.1	0.4	0.7	-1.1	-1.0	1.2	0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.3	1.4	0.1	-1.2	0.4	-0.6	-0.3	0.4	0.6	0.5	0.4	-0.2	0.1	-0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	-0.3	-0.4	-0.6	-0.8	-0.1	-0.8	0.5	-0.4	-0.5	-0.5	-0.2	-0.8
Illnesses of father: High blood pressure	0.2	0.2	0.6	0.4	0.1	0.5	-0.4	0.0	0.2	0.6	0.6	-0.6	0.2	0.8	0.0
Pain experienced in last month	0.2	0.4	2.1	0.0	-0.1	-0.7	-0.2	0.2	-0.3	0.9	-0.6	-0.0	0.5	-0.7	-1.4
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.8	-0.4	0.8	-0.3	-0.5	0.5	0.4	-0.9	-0.7	0.5	0.5	-0.7	0.6
Severe depression (siblings)	0.1	0.2	0.4	0.3	-0.5	-0.3	-0.4	0.4	-0.2	-0.0	-0.4	-0.4	0.5	-0.4	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.8	0.2	0.2	0.5	0.7	-0.2	0.5	0.6	0.4	-0.9	-0.5	0.7	0.2
Alcohol intake versus 10 years previously	0.1	0.2	0.6	-0.4	-0.1	0.2	-0.2	0.2	-0.1	0.7	0.0	-0.7	-0.1	0.4	-0.8
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	0.1	0.1	0.1	-0.5	0.2	-0.2	-0.4	-0.3	0.6	-0.2	-0.2	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.0	-0.7	-0.3	-0.2	-0.4	-0.3	0.4	0.1	-0.3	-0.6	-0.1	-0.2
Suffer from ‘nerves’	0.1	0.2	0.5	0.2	0.6	0.3	0.7	-0.3	0.5	-0.5	0.5	0.3	-0.3	0.3	0.5
Age at last live birth	0.1	0.2	0.8	-0.4	-0.0	-0.2	-0.4	0.1	-0.1	-0.4	-0.2	0.9	0.0	-0.7	0.1
Loneliness, isolation	0.1	0.2	0.4	-0.5	0.7	0.1	-0.1	-0.6	-0.3	-0.7	0.7	0.2	-0.1	-0.1	0.6
Wears glasses or contact lenses	0.1	0.2	0.5	-0.3	0.4	-0.4	-0.5	-0.7	-0.7	-0.1	0.4	-0.1	-0.3	-0.3	0.1
Ever smoked	0.1	0.2	1.5	0.3	-0.9	0.1	-1.2	0.3	0.1	-0.1	-0.3	-0.2	-0.3	-0.0	-0.4
Cholesterol lowering medication	0.1	0.1	0.3	-0.5	-0.4	-0.1	-0.3	-0.2	0.2	0.5	-0.1	-0.1	-0.4	0.6	-0.5
Depression (Nagel 2018)	0.0	0.1	0.2	0.3	-0.3	0.1	0.0	-0.1	-0.4	-0.3	0.1	-0.3	0.1	-0.4	-0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.4	1.1	0.9	1.0	0.4	0.9	-0.7	0.5	0.4	1.0	0.3	0.2	-0.3	0.5
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	-0.1	-0.1	-0.3	0.1	-0.2	0.0	-0.0	-0.2	0.2	-0.0	-0.1	-0.1
Mean time to correctly identify matches	0.0	0.1	0.2	-0.2	0.1	0.3	-0.1	-0.2	0.2	-0.4	0.4	-0.4	0.3	0.2	0.3
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.2	0.0	0.1	-0.2	0.2	-0.0	-0.1	-0.1	-0.1	-0.2	0.3	-0.2	0.4

Hub : Genes

ECM2

Models

Trait associations