Best TWAS P=7.77e-14 · Best GWAS P=1.14e-13 conditioned to 0.000844
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | PLEKHA1 | 0.14 | 0.06 | lasso | 2 | 0.03 | 2.4e-03 | 6.8 | -6.9 | 6.9e-12 | 0.21 | 0.26 | 0.64 | FALSE |
2 | GTEx | Nerve Tibial | PLEKHA1 | 0.22 | 0.23 | enet | 17 | 0.19 | 1.1e-13 | 6.8 | -5.9 | 4.4e-09 | 0.18 | 0.30 | 0.70 | FALSE |
3 | GTEx | Skin Sun Exposed Lower leg | PLEKHA1 | 0.16 | 0.02 | lasso | 5 | 0.01 | 4.0e-02 | -5.5 | -5.9 | 3.1e-09 | 0.30 | 0.08 | 0.82 | FALSE |
4 | METSIM | Adipose | PLEKHA1 | 0.05 | 0.03 | lasso | 4 | 0.04 | 3.6e-07 | 6.7 | -6.8 | 1.3e-11 | 0.32 | 0.21 | 0.78 | TRUE |
5 | ROSMAP | Brain Pre-frontal Cortex | PLEKHA1 | 0.06 | 0.05 | lasso | 4 | 0.05 | 1.3e-06 | -7.2 | -7.2 | 7.2e-13 | 0.29 | 0.03 | 0.97 | FALSE |
6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ARMS2 | 0.04 | 0.02 | lasso | 3 | 0.01 | 2.7e-02 | -2.4 | -5.2 | 1.8e-07 | 0.24 | 0.02 | 0.94 | FALSE |
7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PLEKHA1 | 0.04 | 0.05 | lasso | 2 | 0.04 | 4.3e-05 | 6.8 | -6.8 | 1.2e-11 | 0.21 | 0.24 | 0.70 | FALSE |
8 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ARMS2 | 0.23 | 0.20 | lasso | 2 | 0.21 | 7.0e-09 | -7.2 | -7.5 | 7.8e-14 | 0.55 | 0.01 | 0.99 | TRUE |
9 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | PLEKHA1 | 0.08 | 0.06 | blup | 103 | 0.02 | 4.0e-02 | 6.7 | -6.1 | 1.2e-09 | 0.19 | 0.05 | 0.49 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ARMS2 | 0.06 | 0.04 | blup | 71 | 0.05 | 4.9e-06 | -7.2 | -7.1 | 1.4e-12 | 0.31 | 0.02 | 0.97 | FALSE |
11 | The Cancer Genome Atlas | Thyroid Carcinoma | PLEKHA1 | 0.08 | 0.10 | lasso | 1 | 0.09 | 3.5e-09 | 6.7 | -6.7 | 2.2e-11 | 0.21 | 0.39 | 0.61 | FALSE |