Best TWAS P=8.47e-11 · Best GWAS P=1.66e-11 conditioned to 2.81e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellum | COPB1 | 0.16 | 0.09 | lasso | 8 | 0.06 | 9.3e-03 | 5.6 | -5.2 | 1.8e-07 | -0.22 | 0.23 | 0.10 | FALSE |
| 2 | GTEx | Heart Atrial Appendage | PDE3B | 0.17 | 0.05 | lasso | 9 | 0.04 | 5.3e-03 | -4.8 | -5.4 | 6.5e-08 | -0.15 | 0.16 | 0.10 | FALSE |
| 3 | GTEx | Testis | RRAS2 | 0.18 | 0.13 | enet | 19 | 0.15 | 2.7e-07 | -5.0 | 6.5 | 8.5e-11 | 0.20 | 0.27 | 0.73 | TRUE |
| 4 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | RRAS2 | 0.13 | 0.01 | blup | 11 | 0.05 | 4.0e-03 | 5.8 | 5.4 | 6.5e-08 | 0.46 | 0.00 | 0.93 | FALSE |