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chr11:16,343,081-19,345,331

Best TWAS P=4.79e-13 · Best GWAS P=4.67e-11 conditioned to 0.00539

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
7	GTEx	Brain Cortex	KCNJ11	0.17	0.01	enet	24	0.06	7.7e-03	-5.6	7.2	4.8e-13	0.54	0.07	0.61	TRUE
4	GTEx	Artery Aorta	SPTY2D1	0.13	0.17	enet	10	0.16	2.5e-09	5.2	5.6	2.7e-08	0.06	0.00	1.00	TRUE
14	GTEx	Colon Transverse	OR7E14P	0.21	0.21	enet	21	0.26	7.3e-13	6.2	-7.2	7.8e-13	-0.53	0.11	0.89	FALSE
16	GTEx	Esophagus Mucosa	OR7E14P	0.33	0.32	enet	31	0.41	1.6e-29	-5.6	-7.1	1.2e-12	-0.58	0.18	0.82	FALSE
23	GTEx	Lung	OR7E14P	0.22	0.13	enet	28	0.26	3.4e-20	-5.6	-6.9	6.5e-12	-0.43	0.26	0.74	FALSE
43	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	DKFZp686O24166	0.04	0.00	blup	71	0.02	7.1e-03	-4.8	-6.8	7.8e-12	-0.79	0.01	0.80	FALSE
11	GTEx	Cells Transformed fibroblasts	PIK3C2A	0.10	0.08	lasso	4	0.08	1.3e-06	6.1	-6.8	1.2e-11	-0.60	0.08	0.91	FALSE
1	CommonMind	Brain Pre-frontal Cortex	KCNJ11	0.04	0.03	lasso	3	0.03	2.6e-04	6.1	6.7	1.7e-11	0.93	0.02	0.97	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NUCB2	0.10	0.04	enet	8	0.05	2.6e-06	-5.8	-6.7	2.1e-11	-0.70	0.23	0.70	FALSE
33	GTEx	Small Intestine Terminal Ileum	OR7E14P	0.29	0.10	enet	19	0.22	1.3e-05	-3.0	-6.6	3.1e-11	-0.49	0.11	0.56	FALSE
49	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PIK3C2A	0.05	0.01	blup	52	0.03	7.2e-03	6.1	-6.6	4.9e-11	-0.66	0.02	0.66	FALSE
35	GTEx	Stomach	OR7E14P	0.23	0.07	enet	25	0.01	7.5e-02	-6.0	-6.6	5.5e-11	-0.57	0.18	0.74	FALSE
31	GTEx	Skin Sun Exposed Lower leg	KCNJ11	0.23	0.09	lasso	10	0.12	1.7e-10	6.5	-6.5	6.3e-11	-0.89	0.01	0.99	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	KCNJ11	0.18	0.07	lasso	6	0.12	7.0e-07	6.1	-6.5	6.4e-11	-0.85	0.02	0.98	FALSE
2	GTEx	Adipose Subcutaneous	OR7E14P	0.10	0.09	lasso	5	0.10	1.2e-08	-6.0	-6.5	9.1e-11	-0.64	0.20	0.80	FALSE
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DKFZp686O24166	0.03	0.01	blup	72	0.03	2.4e-04	6.5	-6.5	1.0e-10	-0.83	0.01	0.95	FALSE
15	GTEx	Esophagus Mucosa	NUCB2	0.08	0.03	lasso	4	0.04	8.8e-04	6.1	-6.4	2.0e-10	-0.56	0.14	0.80	FALSE
28	GTEx	Pancreas	OR7E14P	0.30	0.15	lasso	10	0.23	3.5e-10	-3.2	-6.4	2.0e-10	-0.31	0.65	0.26	FALSE
13	GTEx	Colon Transverse	NUCB2	0.13	0.09	lasso	6	0.06	9.6e-04	-6.0	-6.3	2.2e-10	-0.58	0.16	0.81	FALSE
20	GTEx	Esophagus Muscularis	RP1-239B22.5	0.06	0.08	enet	8	0.08	1.3e-05	-6.0	-6.3	2.7e-10	-0.60	0.15	0.80	FALSE
32	GTEx	Skin Sun Exposed Lower leg	RP1-239B22.5	0.06	0.06	lasso	2	0.07	8.6e-07	-4.9	-6.3	2.7e-10	-0.83	0.03	0.96	FALSE
40	METSIM	Adipose	NUCB2	0.05	0.07	enet	10	0.05	4.0e-08	-6.0	-6.2	5.6e-10	-0.58	0.25	0.75	FALSE
30	GTEx	Skin Sun Exposed Lower leg	OR7E14P	0.11	0.05	lasso	6	0.08	4.3e-07	6.1	-6.2	6.5e-10	-0.48	0.06	0.93	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	PIK3C2A	0.08	0.05	lasso	3	0.05	9.6e-06	6.1	-6.2	6.9e-10	-0.59	0.02	0.98	FALSE
8	GTEx	Breast Mammary Tissue	OR7E14P	0.21	0.06	enet	23	0.08	7.7e-05	6.1	-6.2	7.8e-10	-0.46	0.12	0.87	FALSE
12	GTEx	Cells Transformed fibroblasts	NUCB2	0.13	0.11	lasso	2	0.09	1.7e-07	-6.0	-6.2	7.8e-10	-0.53	0.24	0.76	FALSE
25	GTEx	Nerve Tibial	OR7E14P	0.18	0.28	lasso	3	0.28	9.5e-20	6.1	-6.1	9.1e-10	-0.57	0.10	0.90	FALSE
17	GTEx	Esophagus Mucosa	KCNJ11	0.27	0.16	lasso	8	0.22	1.6e-14	-4.4	-6.1	1.1e-09	-0.77	0.43	0.57	FALSE
45	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DKFZp686O24166	0.05	0.03	blup	71	0.04	1.2e-05	-4.7	-6.1	1.1e-09	-0.81	0.02	0.97	FALSE
3	GTEx	Adipose Subcutaneous	RP1-239B22.5	0.11	0.06	enet	21	0.07	1.5e-06	6.5	-6.1	1.2e-09	-0.80	0.01	0.99	FALSE
37	GTEx	Testis	OR7E14P	0.38	0.33	lasso	6	0.32	7.1e-15	6.1	-6.1	1.2e-09	-0.57	0.12	0.88	FALSE
44	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	DKFZp686O24166	0.08	0.04	blup	72	0.01	1.4e-01	-4.8	-6.0	1.5e-09	-0.56	0.03	0.09	FALSE
21	GTEx	Heart Atrial Appendage	OR7E14P	0.14	0.02	lasso	1	0.03	1.7e-02	-6.0	-6.0	2.3e-09	-0.58	0.09	0.46	FALSE
19	GTEx	Esophagus Mucosa	RP1-239B22.5	0.28	0.28	enet	47	0.32	2.9e-22	-4.6	-6.0	2.6e-09	-0.74	0.96	0.04	FALSE
39	GTEx	Thyroid	RP1-239B22.5	0.08	0.07	enet	16	0.08	1.8e-06	6.6	-6.0	2.7e-09	-0.84	0.01	0.99	FALSE
50	The Cancer Genome Atlas	Lung Adenocarcinoma	DKFZp686O24166	0.04	0.01	blup	71	0.02	1.5e-03	6.3	-5.9	2.8e-09	-0.80	0.01	0.89	FALSE
18	GTEx	Esophagus Mucosa	NCR3LG1	0.38	0.38	enet	39	0.42	3.7e-30	-4.4	-5.9	2.9e-09	-0.72	1.00	0.00	FALSE
48	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DKFZp686O24166	0.08	0.07	lasso	4	0.05	1.2e-03	-4.8	-5.9	3.8e-09	-0.72	0.04	0.92	FALSE
34	GTEx	Spleen	NUCB2	0.20	0.21	lasso	2	0.17	4.2e-05	-5.8	-5.9	4.4e-09	-0.50	0.14	0.54	FALSE
5	GTEx	Artery Tibial	OR7E14P	0.10	0.07	lasso	8	0.04	3.4e-04	-6.2	-5.9	4.5e-09	-0.57	0.10	0.88	FALSE
24	GTEx	Muscle Skeletal	OR7E14P	0.05	0.04	enet	13	0.03	7.5e-04	-5.9	-5.9	4.7e-09	-0.59	0.18	0.81	FALSE
22	GTEx	Heart Left Ventricle	OR7E14P	0.08	0.06	enet	18	0.07	1.2e-04	-6.2	-5.8	7.1e-09	-0.48	0.11	0.63	FALSE
9	GTEx	Breast Mammary Tissue (Male)	OR7E14P	0.17	0.00	enet	17	0.03	8.3e-02	-2.5	-5.4	6.2e-08	-0.31	0.06	0.20	FALSE
53	The Cancer Genome Atlas	Skin Cutaneous Melanoma	PIK3C2A	0.10	0.09	lasso	7	0.09	2.7e-03	-6.0	-5.4	6.5e-08	-0.52	0.03	0.52	FALSE
36	GTEx	Testis	NUCB2	0.28	0.13	lasso	9	0.10	2.5e-05	-6.0	5.4	6.9e-08	0.47	0.26	0.58	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	NUCB2	0.36	0.23	lasso	6	0.24	2.6e-08	-5.8	-5.4	7.1e-08	-0.50	0.23	0.76	FALSE
38	GTEx	Thyroid	OR7E14P	0.16	0.11	lasso	4	0.13	2.6e-10	-3.2	-5.3	9.3e-08	-0.22	0.99	0.00	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	OR7E14P	0.04	0.04	lasso	4	0.04	9.1e-06	-5.8	-5.3	1.2e-07	-0.58	0.15	0.84	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	KCNJ11	0.05	0.06	enet	6	0.05	3.0e-07	5.7	5.3	1.2e-07	0.73	0.20	0.79	FALSE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUCB2	0.17	0.06	blup	66	0.06	2.8e-07	5.7	5.3	1.2e-07	0.71	0.35	0.65	FALSE
27	GTEx	Ovary	NUCB2	0.31	-0.01	enet	35	0.01	2.0e-01	-6.0	-5.3	1.3e-07	-0.50	0.07	0.40	FALSE
6	GTEx	Brain Cortex	NUCB2	0.21	0.12	lasso	4	0.10	1.1e-03	-4.4	5.2	2.1e-07	0.53	0.20	0.49	FALSE
26	GTEx	Nerve Tibial	RP1-239B22.5	0.11	0.08	lasso	2	0.08	2.9e-06	-3.0	-5.2	2.5e-07	-0.74	0.03	0.92	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	SPTY2D1	0.14	0.20	lasso	3	0.20	4.4e-21	5.2	5.2	2.6e-07	0.06	0.00	0.99	FALSE