Best TWAS P=2.43e-09 · Best GWAS P=7.2e-08 conditioned to 0.831
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Whole Blood | ARL14EP | 0.07 | 0.05 | lasso | 2 | 0.05 | 3.3e-05 | -5.11 | 5.2 | 2.1e-07 | -0.95 | 0.01 | 0.99 | FALSE |
2 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C11orf46 | 0.05 | 0.05 | lasso | 5 | 0.06 | 6.2e-12 | -5.39 | 5.8 | 8.8e-09 | -0.96 | 0.00 | 1.00 | FALSE |
3 | The Cancer Genome Atlas | Colon Adenocarcinoma | C11orf46 | 0.12 | 0.08 | blup | 34 | 0.07 | 5.7e-05 | 4.37 | 5.8 | 6.0e-09 | -0.80 | 0.02 | 0.82 | FALSE |
4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C11orf46 | 0.06 | 0.06 | lasso | 2 | 0.05 | 5.5e-06 | -5.23 | 5.2 | 1.5e-07 | -0.94 | 0.01 | 0.99 | FALSE |
5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C11orf46 | 0.36 | 0.27 | lasso | 5 | 0.30 | 8.3e-34 | -5.23 | 5.8 | 7.5e-09 | -0.93 | 0.01 | 0.99 | FALSE |
6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C11orf46 | 0.13 | 0.12 | lasso | 3 | 0.11 | 8.9e-07 | -5.23 | 5.2 | 1.5e-07 | -0.94 | 0.00 | 0.99 | FALSE |
7 | The Cancer Genome Atlas | Lung Adenocarcinoma | C11orf46 | 0.09 | 0.11 | lasso | 4 | 0.10 | 1.2e-11 | -5.23 | 5.5 | 3.3e-08 | -0.96 | 0.01 | 0.99 | FALSE |
8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C11orf46 | 0.05 | 0.02 | lasso | 2 | 0.02 | 9.9e-04 | 4.21 | 5.5 | 4.5e-08 | -0.77 | 0.01 | 0.77 | FALSE |
9 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C11orf46 | 0.07 | 0.04 | blup | 34 | 0.07 | 2.5e-05 | 4.08 | 5.5 | 4.5e-08 | -0.78 | 0.03 | 0.92 | FALSE |
10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C11orf46 | 0.22 | 0.22 | lasso | 3 | 0.20 | 1.1e-08 | -5.23 | 5.3 | 1.1e-07 | -0.95 | 0.00 | 0.99 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C11orf46 | 0.09 | 0.07 | lasso | 2 | 0.06 | 2.4e-07 | -5.23 | 5.2 | 1.7e-07 | -0.94 | 0.00 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Stomach Adenocarcinoma | C11orf46 | 0.11 | 0.05 | enet | 7 | 0.09 | 3.4e-07 | -5.39 | 6.0 | 2.4e-09 | -0.89 | 0.00 | 1.00 | TRUE |
13 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | MPPED2 | 0.20 | -0.01 | blup | 147 | 0.05 | 2.0e-02 | 0.63 | 5.3 | 1.4e-07 | -0.62 | 0.02 | 0.18 | FALSE |