Hub : Genes

PDS5B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1920	0.0610	1.6e-03	0.006	NA	0.022	NA	0.011	1.4e-01	NA	2.2e-02	NA	8.0e-02
2	YFS	Blood	0.0276	0.0083	7.6e-08	0.038	0.024	0.032	0.028	0.035	2.3e-12	1.4e-08	7.2e-11	1.4e-09	1.4e-11
3	TCGA	Thyroid Carcinoma	0.0190	0.0140	9.2e-03	0.011	0.015	0.010	NA	0.007	2.5e-02	1.2e-02	3.4e-02	NA	6.8e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.1	0.3	-0.1	0.6	-0.3
Bipolar Disorder or Schizophrenia	0.3	0.7	1.0	0.6	1.0	-0.8
Depressed Affect (Nagel 2018)	0.7	1.5	2.4	-0.4	-1.6	1.4
Depression (Nagel 2018)	1.9	2.9	4.7	-0.7	-1.8	2.2
Intelligence (Savage-Jansen 2018)	0.9	2.8	5.5	0.9	-2.3	1.5
Neuroticism (Nagel 2018)	0.1	0.3	0.6	0.4	-0.3	0.7
Schizophrenia (2018)	0.3	0.6	0.7	0.8	0.8	-0.8
Schizophrenia vs Biploar Disorder	0.7	0.9	2.7	-1.6	0.3	-0.1
Worry (Nagel 2018)	0.6	1.2	1.6	1.1	1.3	-0.9
Alzheimer’s Disease (in mother)	1.6	1.8	3.2	1.8	1.1	-1.1
Alzheimer’s Disease (in father)	0.1	0.1	0.3	0.0	0.5	0.0
Alzheimer’s Disease (including proxy)	1.0	1.5	2.4	1.1	1.5	-1.0
Crohns Disease (2017)	0.2	0.4	0.7	-0.5	0.4	-0.8
Irritable Bowel Disease (IBD)	0.2	0.4	0.7	-0.8	-0.6	0.3
Ulcerative Colitis (UC)	0.3	0.6	0.7	-0.8	-0.9	0.7
Major Depression (MDD)	0.0	0.0	0.1	0.3	-0.1	0.0
Reaction Time	0.8	1.5	3.4	1.8	0.7	-0.9
Verbal and Numeric Reasoning (VNR)	0.8	1.9	3.6	-0.4	-1.9	1.4
Breast Cancer	1.0	2.4	5.2	-2.3	-0.9	1.1
Ovarian Cancer	0.7	0.9	2.5	-1.6	-0.3	0.4
Prostate Cancer	0.7	1.0	1.8	0.2	-1.3	1.2
Age at First Birth	0.1	0.1	0.2	0.4	-0.5	0.1
Bipolar Disorder (2011)	0.8	0.8	2.2	1.5	0.3	-0.1
Body Mass Index (BMI) (2010)	4.9	6.7	10.3	-1.3	-2.8	3.2
Coronary Artery Disease (CAD)	1.7	2.0	2.5	-1.0	-1.6	1.6
Crohns Disease (2012)	0.0	0.0	0.1	-0.0	-0.2	-0.3
Mean Putamen Volume	0.2	0.2	0.3	0.5	-0.6	0.3
Fasting Glucose	0.2	0.3	0.3	-0.4	0.6	-0.5
HbA1C	0.5	0.6	1.0	-1.0	-0.6	0.7
HDL Cholesterol	1.0	1.6	4.8	-2.2	-0.1	0.3
LDL Cholesterol	0.6	1.0	1.5	0.3	-1.2	1.2
Lupus	0.4	0.5	0.9	-1.0	-0.5	0.6
Neuroticism (2016)	0.2	0.3	0.7	-0.1	-0.4	0.9
Primary Biliary Cirrhosis	1.9	2.7	3.8	-0.8	-1.9	1.9
Rheumatoid Arthritis	1.2	1.6	2.9	1.7	0.7	-1.2
Schizophrenia (2014)	0.2	0.4	1.1	-1.0	0.2	-0.3
Triglycerides	0.8	1.3	1.5	-1.1	-1.1	1.2
Type 2 Diabetes (T2D) (2012)	4.3	4.9	7.7	-0.5	-2.8	2.6
Ulcerative Colitis	1.5	2.2	2.5	-1.4	-1.4	1.6
Blood Eosinophil Count	0.5	3.6	5.1	-1.1	2.2	-2.1
Blood Platelet Count	6.0	69.2	122.1	3.0	8.7	-11.0
Blood Red Count	0.0	0.1	0.3	0.0	0.5	-0.2
Blood White Count	0.1	0.8	1.4	-0.4	-1.2	0.9
Heel T-Score	2.9	23.0	34.7	-1.2	-5.7	5.9
BMI	7.6	44.0	66.1	-2.6	-7.7	8.1
Height	3.4	65.0	100.0	5.5	8.0	-10.0
Waist Hip Ratio (WHR)	0.3	1.1	1.7	0.4	1.3	-1.2
Systolic Blood Pressure	1.3	6.6	18.1	-4.3	-0.5	1.2
Smoking Status	0.4	0.9	1.7	0.3	-0.9	1.3
Allergy or Eczema	0.2	0.6	1.4	1.2	0.4	-0.6
Cardiovascular Disease	2.2	7.3	8.8	-3.0	-2.2	2.9
Hypothyroidism (self reported)	4.0	9.3	15.0	-2.0	-3.0	3.9
Respiratory disease	0.1	0.2	0.3	0.6	-0.4	0.3
Type 2 Diabetes (T2D) (2018)	0.6	1.2	1.9	-0.8	-1.0	1.4
Lung FEV1/FVC ratio	0.1	0.7	1.3	1.1	-0.8	0.3
Lung FVC	0.1	0.3	0.7	-0.8	0.5	0.1
Neuroticism	0.0	0.0	0.0	-0.2	0.1	-0.1
Chronotype (morning person)	1.1	2.5	3.7	-0.5	1.9	-1.9
Hair Pigment	0.1	2.3	6.2	2.5	-0.7	0.5
Tanning	0.8	9.8	16.3	1.3	3.4	-4.0
Hand grip strength (left)	2.5	6.5	11.5	-0.2	-2.8	3.4
Number of treatments/medications taken	0.0	0.0	0.0	-0.1	0.0	0.1
Average weekly spirits intake	0.9	1.1	2.0	0.1	-1.4	1.2
Sensitivity / hurt feelings	0.3	0.6	1.1	1.1	-0.5	0.5
Frequency of depressed mood in last 2 weeks	3.1	4.3	6.2	-0.9	-2.5	2.5
Hearing difficulty/problems: Yes	0.1	0.2	0.3	0.5	0.1	0.5
Relative age of first facial hair	0.9	1.9	4.8	2.2	-0.6	0.8
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.2	0.2	-0.5
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.1	0.1	-0.4	-0.3
Ever had hysterectomy (womb removed)	0.3	0.4	0.7	0.3	-0.8	0.6
Systolic blood pressure, automated reading	1.6	4.7	10.5	-3.2	-1.1	1.5
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	2.9	-1.7	-1.6	1.1
Angina	1.3	1.7	2.6	-1.1	-1.2	1.6
Medication for hormone replacement therapy	1.2	1.3	2.0	-0.6	1.3	-1.4
Vitamin and mineral supplements	1.1	1.5	1.9	1.4	-0.9	1.3
Supplements: Zinc	1.2	1.3	2.2	-1.5	1.1	-0.7
Medication: Co-codamol	1.6	1.8	5.4	2.3	-0.2	0.3
Medication: Metformin	0.4	0.5	0.7	-0.6	-0.8	0.8
Diabetes (father)	0.0	0.1	0.1	-0.3	0.3	-0.1
Diabetes (mother)	0.2	0.3	0.5	-0.4	-0.7	0.5
Severe depression (siblings)	1.1	1.3	3.3	1.8	-0.6	0.5
Pack years adult smoking proportion	0.7	1.1	2.4	0.0	-1.0	1.6
Impedance of leg (right)	1.0	4.9	8.3	1.9	1.7	-2.9
Leg fat-free mass (left)	0.2	1.1	1.8	-1.4	-0.7	0.9
Trunk fat percentage	3.3	13.0	18.7	-2.3	-4.3	3.9
Hand grip strength (right)	2.2	5.9	10.1	-0.7	-2.6	3.2
Townsend deprivation index at recruitment	0.2	0.3	0.7	-0.8	0.5	0.1
Current tobacco smoking	0.2	0.3	0.4	-0.0	-0.6	0.7
Average weekly fortified wine intake	1.1	1.3	3.7	-1.9	0.2	-0.3
Maternal smoking around birth	2.0	2.9	3.5	-1.9	-1.4	1.9
Fed-up feelings	0.1	0.1	0.3	0.5	-0.3	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	4.6	-0.5	-1.6	2.2
Relative age voice broke	1.4	2.2	3.7	0.9	1.9	-1.4
Taking other prescription medications	0.5	0.8	1.8	1.3	-0.6	0.5
Age when periods started (menarche)	3.9	9.4	14.1	1.1	3.8	-3.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.0	0.0	-1.0	0.6
Heel bone mineral density (BMD) T-score, automated (left)	2.4	5.5	7.3	-2.7	-1.9	2.3
Tinnitus: Yes, but not now, but have in the past	2.9	3.1	3.8	-1.3	-1.9	1.9
Qualifications: CSEs or equivalent	0.6	0.8	1.8	-1.4	0.6	-0.3
Serious illness, injury or assault to yourself	1.7	2.1	3.6	-0.6	-1.5	1.9
High blood pressure	1.3	3.6	7.7	-2.8	-1.0	1.5
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.7	1.3	0.2	-0.3
Multivitamins +/- minerals	1.5	1.9	2.5	-1.0	1.6	-1.5
Stomach or abdominal pain in last month	0.9	1.2	1.6	-0.9	-1.0	1.2
Supplements: Glucosamine	0.9	1.1	2.5	0.2	0.9	-1.6
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	2.7	-1.6	-1.1	0.8
Medication: Atenolol	0.1	0.1	0.1	0.3	-0.2	0.3
Medication: Levothyroxine sodium	3.9	6.7	9.1	-2.2	-2.5	3.0
Sitting height	1.6	11.3	18.3	2.2	3.3	-4.3
Chronic bronchitis/emphysema (father)	2.3	2.6	3.8	-1.9	-1.6	1.2
High blood pressure (mother)	1.9	2.7	6.9	-2.6	-0.9	0.6
Body mass index (BMI)	5.9	25.0	34.1	-3.6	-5.3	5.8
Impedance of leg (left)	0.7	3.4	4.8	2.1	0.9	-2.2
Leg predicted mass (left)	0.2	1.2	2.0	-1.4	-0.7	1.0
Trunk fat mass	2.5	10.6	14.8	-2.2	-3.8	3.5
Waist circumference	2.0	7.3	9.0	-2.2	-2.8	3.0
Number of incorrect matches in round	0.8	1.4	2.6	0.5	1.2	-1.6
Past tobacco smoking	0.4	0.8	1.6	0.2	0.8	-1.3
Alcohol usually taken with meals	1.0	1.7	2.8	1.7	0.9	-1.2
Nervous feelings	0.2	0.3	0.7	-0.1	0.8	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.0	-0.2	0.2	0.2
Hearing difficulty/problems with background noise	1.4	2.2	3.2	-1.8	-0.9	1.6
Hair/balding pattern: Pattern 2	3.9	5.0	8.3	-0.7	-2.5	2.9
Had menopause	1.0	1.2	2.5	-1.6	-0.9	0.5
Had other major operations	0.6	0.8	1.4	-0.4	-0.9	1.2
Forced vital capacity (FVC)	0.2	0.7	1.3	0.4	1.1	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	1.9	-1.3	-1.3	1.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.7	-1.3	0.2	0.1
Qualifications: None of the above	0.3	0.6	1.6	0.3	-0.5	1.2
Financial difficulties in last 2 years	0.1	0.1	0.2	-0.5	0.3	-0.1
Mouth/teeth dental problems	0.4	0.6	1.0	1.0	0.3	-0.9
Heart attack	1.0	1.3	2.3	-0.7	-1.0	1.5
Allergy	0.3	0.7	1.8	-1.3	0.2	-0.4
Pain all over the body in last month	0.8	0.8	2.0	1.4	0.3	-0.6
Diabetes (self-reported)	0.3	0.5	0.9	-0.9	-0.4	0.7
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	4.2	0.2	1.8	-2.1
Medication: Ramipril	0.1	0.1	0.2	-0.5	-0.1	0.1
Medication: Simvastatin	1.5	2.2	3.6	-0.2	-1.7	1.9
Fluid intelligence score	0.3	0.6	0.7	0.9	-0.9	0.4
Illnesses of siblings	0.5	0.7	1.9	1.4	-0.5	0.2
Neuroticism score	0.1	0.1	0.1	0.4	0.3	-0.4
Weight	1.2	6.1	7.4	-2.0	-2.6	2.7
Impedance of arm (right)	1.1	5.0	8.3	1.5	2.1	-2.9
Arm fat percentage (right)	5.7	22.6	29.5	-3.5	-5.1	5.4
Trunk fat-free mass	0.1	0.4	0.5	-0.7	0.7	-0.5
Hip circumference	2.0	8.7	10.6	-2.3	-3.2	3.3
Time employed in main current job	0.7	0.8	1.6	-1.2	-0.6	0.8
Alcohol intake versus 10 years previously	0.5	0.8	1.5	-0.6	-0.7	1.2
Father’s age at death	1.9	2.6	3.4	1.8	1.0	-1.8
Worrier / anxious feelings	0.3	0.5	0.9	0.4	0.9	-0.7
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	2.7	1.6	-1.5	1.6
Falls in the last year	0.2	0.2	0.3	-0.3	0.6	-0.5
Hair/balding pattern: Pattern 3	2.9	4.3	6.7	1.1	2.3	-2.6
Number of live births	0.8	1.1	2.5	0.4	-0.9	1.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.1	0.3	1.0	-0.8
Pulse rate	1.0	1.6	2.5	-0.1	1.6	-1.5
Happiness	0.7	0.9	1.1	-0.7	1.0	-1.0
Noisy workplace	0.2	0.3	0.3	-0.6	-0.5	0.5
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.1	0.1	-0.3	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	-0.1	-0.4	0.4
Mouth/teeth dental problems: Dentures	0.4	0.7	1.0	-0.4	-0.9	1.0
Asthma	0.2	0.4	0.5	0.7	-0.7	0.6
Medication: Ibuprofen (e.g. Nurofen)	4.1	5.2	8.9	0.5	2.5	-3.0
Medication: Cholesterol lowering	3.4	5.2	9.2	-1.1	-2.3	3.0
Depression (self-reported)	1.7	2.0	3.1	-0.2	1.7	-1.8
Medication: Lansoprazole	0.5	0.5	1.2	-0.5	-0.5	1.1
Prospective memory result	0.1	0.1	0.3	0.5	0.1	0.0
Lung cancer (father)	1.0	1.2	1.8	1.3	-1.0	0.9
Illnesses of mother	1.3	1.6	2.5	1.6	0.9	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	3.6	1.3	1.9	-1.9
Pulse wave Arterial Stiffness index	0.8	0.9	1.6	0.5	0.9	-1.3
Impedance of arm (left)	1.1	5.2	8.0	1.9	2.0	-2.8
Arm fat mass (right)	3.8	15.7	19.7	-3.2	-4.2	4.4
Trunk predicted mass	0.1	0.4	0.5	-0.7	0.7	-0.5
Standing height	2.7	26.7	41.0	3.2	5.3	-6.4
Length of working week for main job	0.1	0.1	0.3	-0.5	-0.2	0.1
Exposure to tobacco smoke at home	0.2	0.2	0.6	-0.8	0.3	-0.2
Breastfed as a baby	0.1	0.1	0.2	-0.5	0.0	0.3
Tense / ‘highly strung’	0.0	0.0	0.0	0.2	-0.2	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.3	5.5	-0.1	-2.3	2.1
Hair/balding pattern: Pattern 4	1.7	4.0	4.5	-1.9	-2.0	2.1
Birth weight of first child	0.9	1.6	2.6	0.5	1.4	-1.6
Peak expiratory flow (PEF)	0.0	0.1	0.2	-0.2	0.4	-0.1
Pulse wave reflection index	0.1	0.1	0.3	0.5	0.2	-0.1
Ever highly irritable/argumentative for 2 days	0.8	1.0	1.3	-0.6	-1.1	1.1
Loud music exposure frequency	0.2	0.2	0.4	-0.4	0.0	0.6
Qualifications: O levels/GCSEs or equivalent	0.8	1.4	1.9	0.7	1.3	-1.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.5	-0.5	-0.6	1.2
Blood clot in the leg (DVT)	2.1	2.7	4.4	-0.1	-1.9	2.1
Medication: Paracetamol	0.6	1.0	2.3	1.5	0.4	-0.7
Headache pain in last month	0.2	0.3	0.3	-0.6	-0.6	0.4
Medication for cholesterol, blood pressure or diabetes	3.1	5.2	7.3	2.0	2.1	-2.7
Glaucoma (self-reported)	2.9	3.4	5.3	0.5	2.2	-2.3
Gout (self-reported)	1.9	2.5	4.3	0.2	-2.1	1.8
Hypothyroidism/myxoedema (self-reported)	2.7	5.3	8.9	-1.3	-2.3	3.0
Medication: Amlodipine	3.1	4.4	5.3	-1.9	-2.0	2.3
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.9	-0.1	0.9	-0.7
Birth weight	1.5	3.3	5.9	2.4	1.0	-1.7
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.8	-0.2	-0.3	0.9
High blood pressure (siblings)	1.2	1.7	5.0	-2.2	-0.3	0.4
Forced vital capacity (FVC), Best measure	1.0	3.5	4.0	1.8	2.0	-1.8
Body fat percentage	4.9	19.2	25.5	-3.0	-5.0	4.8
Leg fat percentage (right)	5.1	18.6	23.9	-2.9	-4.9	4.9
Arm fat-free mass (right)	0.0	0.2	0.4	-0.7	-0.3	0.3
Exposure to tobacco smoke outside home	0.2	0.3	0.5	-0.5	-0.3	0.7
Comparative body size at age 10	1.8	5.0	7.2	-0.9	-2.6	2.7
Number of full brothers	0.3	0.4	1.0	-1.0	-0.0	0.4
Worry too long after embarrassment	3.1	5.1	7.2	2.7	2.1	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.1	-0.2	-0.2	0.3
Wheeze or whistling in the chest in last year	2.1	3.8	5.6	-0.7	-2.3	2.4
Number of children fathered	1.6	1.9	3.2	0.1	-1.5	1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.6	0.8	-0.3	-0.3
Age at first live birth	0.9	1.6	2.9	1.7	0.8	-1.2
Pulse wave peak to peak time	0.4	0.5	0.8	-0.4	-0.6	0.9
Health satisfaction	0.6	0.7	2.1	-1.4	0.3	0.2
Shortness of breath walking on level ground	1.8	2.2	3.0	0.7	-1.7	1.7
Qualifications: College or University degree	0.5	1.6	3.3	-0.4	1.2	-1.8
Eye problems/disorders: None of the above	0.2	0.2	0.3	-0.1	-0.6	0.6
Mouth/teeth dental problems: Loose teeth	1.0	1.1	2.3	0.1	-1.0	1.5
Emphysema/chronic bronchitis	0.5	0.5	1.0	0.6	1.0	-0.4
Medication for pain relief, constipation, heartburn	0.3	0.4	0.8	-0.0	-0.7	0.9
Neck or shoulder pain in last month	1.0	1.5	2.3	0.3	1.5	-1.4
Medication: Blood pressure	2.2	3.8	4.7	-2.2	-1.5	2.1
Angina (self-reported)	1.3	1.7	2.3	-1.3	-1.1	1.5
Migraine (self-reported)	1.6	2.0	3.6	0.3	1.5	-1.9
Medication: Ibuprofen	2.0	2.4	4.1	-0.1	1.7	-2.0
Medication: Allopurinol	3.0	4.0	6.1	0.2	-2.5	2.4
Medication: Omeprazole	2.6	3.1	3.8	-1.5	-1.9	1.8
Medication: Seretide 50 evohaler	0.4	0.4	0.6	0.8	-0.6	0.6
Mean time to correctly identify matches	0.1	0.3	0.6	0.8	0.1	-0.5
Heart disease (mother)	3.9	4.8	9.0	-3.0	-1.4	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.7	1.7	-0.7	0.5
Whole body fat mass	3.8	15.7	20.0	-2.9	-4.5	4.4
Leg fat mass (right)	3.8	14.7	18.6	-2.7	-4.3	4.3
Arm predicted mass (right)	0.1	0.5	0.5	-0.7	-0.7	0.6
Pulse rate, automated reading	1.6	5.3	8.3	0.2	2.7	-2.9
Alcohol intake frequency.	0.3	0.7	1.2	-1.1	-0.3	0.9
Comparative height size at age 10	2.7	15.0	27.2	1.3	4.0	-5.2
Number of full sisters	0.5	0.6	0.8	0.8	0.9	-0.7
Suffer from ‘nerves’	1.1	1.8	2.8	1.7	1.3	-1.0
Overall health rating	3.3	7.1	9.4	-1.9	-2.9	3.1
Chest pain or discomfort	3.8	5.5	8.4	0.2	-2.9	2.8
Had major operations	1.7	2.0	5.6	-2.4	-0.4	0.6
Age at last live birth	0.1	0.2	0.2	0.4	0.4	-0.4
Family relationship satisfaction	0.2	0.2	0.4	-0.6	-0.4	0.1
Leg pain on walking	0.4	0.5	1.0	1.0	-0.4	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	0.3	-0.3	0.2
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.7	-0.2	-1.6	1.3
Illness, injury, bereavement, stress in last 2 years	3.4	4.1	6.7	1.1	2.1	-2.6
Medication: Aspirin	5.2	6.8	10.0	-1.8	-2.7	3.2
Supplements: Vitamin C	0.7	0.8	1.6	-0.3	0.9	-1.3
Knee pain experienced in last month	0.0	0.1	0.1	-0.3	-0.2	0.3
Hypertension (Self-reported)	1.5	4.3	7.6	-2.8	-1.3	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.3	-1.1	-0.5	0.6
Illnesses of father: Heart disease	0.8	1.1	1.6	0.8	-0.9	1.2
Illnesses of siblings: Diabetes	0.1	0.2	0.5	-0.7	-0.1	0.0
Smoking status: Previous	0.2	0.3	0.6	0.1	-0.4	0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.4	4.0	0.6	1.6	-2.0
Whole body fat-free mass	0.1	0.3	0.9	-0.9	-0.0	0.2
Leg fat-free mass (right)	0.2	1.1	1.3	-1.1	-0.9	1.2
Arm fat percentage (left)	6.1	24.2	32.2	-3.3	-5.4	5.7
Average weekly red wine intake	0.6	1.0	2.5	-1.6	0.4	-0.4
Handedness (chirality/laterality): Left-handed	1.4	1.7	2.5	-1.5	-0.5	1.6
Mood swings	0.0	0.1	0.1	0.3	0.1	-0.4
Loneliness, isolation	1.2	1.6	2.6	-0.6	-1.6	1.3
Long-standing illness, disability or infirmity	0.1	0.1	0.1	-0.4	-0.2	0.3
Ever had bowel cancer screening	0.3	0.3	0.5	0.5	-0.7	0.5
Diabetes diagnosed by doctor	0.3	0.6	0.9	-0.2	-0.8	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.5	1.2	-0.0	-0.1
Friendships satisfaction	0.4	0.6	1.1	-1.0	0.7	-0.3
Qualifications: nursing, teaching	1.5	2.3	3.1	-1.4	-1.8	1.3
Commuting to job workplace: Walk	0.3	0.3	0.4	-0.7	0.7	-0.2
Eye problems/disorders: Cataract	3.1	3.6	5.8	0.2	-2.4	2.2
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	2.4	-1.4	1.5	-1.3
Medication for cholesterol	0.9	1.3	3.4	1.9	0.5	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.2	-0.5	0.8	-1.1
Back pain experienced in last month	0.1	0.2	0.5	0.7	0.3	-0.0
Mineral and other dietary supplements	0.2	0.2	0.4	0.1	-0.6	0.5
Breast cancer (self-reported)	2.5	3.0	4.6	-0.3	-2.1	2.1
Asthma (self-reported)	0.1	0.3	0.3	0.6	-0.5	0.5
Osteoporosis (self-reported)	1.5	1.8	2.7	0.8	1.5	-1.6
Osteoarthritis (self-reported)	4.2	5.5	8.6	0.8	2.7	-2.9
Medication: Aspirin	4.9	6.3	8.3	-1.9	-2.7	2.9
Medication: Gliclazide	0.4	0.5	1.1	1.0	-0.5	0.2
Illnesses of father: None of the above (group 1)	1.3	1.6	2.4	-0.4	1.5	-1.5
Smoking status: Current	0.5	0.7	1.1	0.0	-1.0	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.4	-0.4	-0.5	0.6
Whole body water mass	0.1	0.4	1.1	-1.1	-0.1	0.3
Leg predicted mass (right)	0.2	1.2	1.4	-1.2	-0.9	1.2
Arm fat mass (left)	4.0	16.5	21.5	-3.0	-4.4	4.6
Number of self-reported non-cancer illnesses	0.4	0.7	1.3	-1.1	-0.7	0.6
Average weekly champagne plus white wine intake	4.3	5.9	8.6	1.1	2.8	-2.9
Miserableness	0.1	0.1	0.2	-0.1	-0.5	0.3
Guilty feelings	0.0	0.1	0.1	0.4	-0.1	0.0
Wears glasses or contact lenses	0.1	0.1	0.2	-0.4	0.3	-0.0
Ever taken oral contraceptive pill	1.0	1.2	1.5	0.9	1.2	-1.0
Hearing aid user	0.1	0.1	0.2	0.0	0.4	-0.5
Mother’s age at death	0.6	0.8	1.2	-0.2	1.1	-1.1
Financial situation satisfaction	0.7	0.9	2.0	-1.4	0.7	-0.5
Tinnitus: Yes, now most or all of the time	1.4	1.6	3.0	-1.7	-0.8	1.0
Commuting to job workplace: Public transport	1.8	2.1	2.3	1.4	1.5	-1.5
Eye problems/disorders: Glaucoma	4.6	5.5	8.4	1.0	2.9	-2.6
Medication: Blood pressure	0.6	1.2	1.4	-1.1	-1.2	1.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.0	0.2	1.0	-0.7
Supplements: Fish oil (including cod liver oil)	0.0	0.1	0.1	0.1	0.4	-0.1
High cholesterol (Self-reported)	0.8	1.4	2.1	-1.2	-0.8	1.5
Medication: Bendroflumethiazide	1.8	2.7	3.7	0.9	1.9	-1.9
Medication: Paracetamol	0.6	1.0	2.9	1.7	-0.2	-0.1
Medication: Lisinopril	0.1	0.2	0.3	-0.2	-0.6	0.4
Medication: Atorvastatin	0.1	0.2	0.4	-0.6	0.3	0.1
Illnesses of father: High blood pressure	0.3	0.3	0.7	0.8	0.5	-0.3
Alcohol drinker status: Never	1.5	1.8	3.2	-0.5	1.8	-1.4
Ever smoked	1.0	1.7	3.0	0.0	-1.4	1.7
Basal metabolic rate	0.2	1.2	1.8	-1.3	-0.8	1.0
Leg fat percentage (left)	5.8	21.1	27.9	-2.8	-5.3	5.2
Arm fat-free mass (left)	0.2	0.8	1.7	-1.3	-0.5	0.7
Number of operations (self-reported)	1.2	1.8	3.6	-1.9	-1.1	0.9
Average weekly beer plus cider intake	1.9	2.8	4.2	-2.1	-1.3	1.6
Irritability	1.1	1.9	2.7	-1.6	-1.2	1.2
Risk taking	0.6	0.9	2.0	0.6	-1.4	0.4
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.5	1.6	-1.1	0.8
Fractured/broken bones in last 5 years	1.2	1.5	2.8	-1.7	-0.7	1.1
Age started oral contraceptive pill	0.0	0.0	0.0	-0.2	-0.1	0.0
Diastolic blood pressure, automated reading	1.8	5.6	6.6	-2.6	-1.9	2.5
Ever depressed for a whole week	0.0	0.0	0.0	0.0	-0.1	0.2
Unable to work because of sickness or disability	0.7	0.9	2.6	-1.6	-0.3	0.3
Commuting to job workplace: Cycle	0.2	0.2	0.5	-0.1	0.4	-0.7
Myopia	0.1	0.1	0.2	-0.5	-0.3	0.1
Vascular/heart problems diagnosed by doctor	1.8	5.0	8.8	3.0	1.4	-2.1
Cholesterol lowering medication	0.7	1.0	1.8	-0.7	-0.9	1.4
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	2.2	-1.1	-1.5	1.4
Pain experienced in last month	0.1	0.2	0.2	0.4	0.5	-0.5
Supplements: Calcium	0.6	0.6	1.1	0.6	1.0	-0.7
Basal cell carcinoma (self-reported)	1.2	1.4	2.2	0.1	-1.5	1.4
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.0	-0.3	-1.0	1.4
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.1	0.4	-1.4	1.5
Heart disease (siblings)	0.7	0.8	1.6	-0.7	-0.5	1.3
Alcohol drinker status: Previous	2.0	2.2	3.6	-0.6	1.6	-1.9
Pack years of smoking	0.9	1.4	2.8	-0.2	-1.1	1.7
Impedance of whole body	1.0	5.3	7.9	2.3	1.6	-2.8
Leg fat mass (left)	3.9	15.3	19.5	-2.6	-4.4	4.4
Arm predicted mass (left)	0.1	0.7	1.2	-1.1	-0.6	0.7