Best TWAS P=6.4e-19 · Best GWAS P=1.8e-19 conditioned to 0.0301
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | NFATC4 | 0.07 | 0.04 | blup | 538 | 0.03 | 8.5e-05 | 5.59 | -6.3 | 2.7e-10 | -0.42 | 0.15 | 0.72 | FALSE |
2 | GTEx | Adipose Subcutaneous | ADCY4 | 0.08 | 0.04 | lasso | 3 | 0.03 | 3.3e-03 | 7.79 | 8.4 | 5.1e-17 | 0.62 | 0.21 | 0.22 | FALSE |
3 | GTEx | Adipose Subcutaneous | LTB4R | 0.14 | 0.12 | lasso | 3 | 0.12 | 1.3e-09 | 7.79 | -7.8 | 6.3e-15 | -0.61 | 0.95 | 0.05 | FALSE |
4 | GTEx | Artery Aorta | LTB4R | 0.27 | 0.01 | lasso | 11 | 0.03 | 6.4e-03 | 5.98 | -5.5 | 3.5e-08 | -0.50 | 0.63 | 0.06 | FALSE |
5 | GTEx | Artery Coronary | CBLN3 | 0.52 | 0.20 | lasso | 7 | 0.24 | 9.7e-09 | 4.57 | -5.1 | 2.9e-07 | -0.12 | 0.96 | 0.01 | FALSE |
6 | GTEx | Brain Cortex | TGM1 | 0.35 | 0.09 | lasso | 12 | 0.06 | 8.4e-03 | 5.22 | 5.4 | 7.1e-08 | 0.59 | 0.17 | 0.44 | FALSE |
7 | GTEx | Brain Hippocampus | ADCY4 | 0.35 | 0.03 | lasso | 10 | 0.07 | 1.1e-02 | 7.28 | 6.2 | 5.4e-10 | 0.49 | 0.07 | 0.23 | FALSE |
8 | GTEx | Breast Mammary Tissue | LTB4R | 0.30 | 0.18 | lasso | 4 | 0.16 | 2.3e-08 | 7.68 | -7.7 | 1.8e-14 | -0.63 | 0.70 | 0.29 | FALSE |
9 | GTEx | Breast Mammary Tissue (Male) | LTB4R | 0.26 | 0.06 | lasso | 4 | 0.03 | 6.7e-02 | 5.98 | -6.4 | 1.7e-10 | -0.53 | 0.06 | 0.15 | FALSE |
10 | GTEx | Breast Mammary Tissue (Female) | LTB4R | 0.12 | 0.02 | lasso | 2 | 0.01 | 2.1e-01 | 7.68 | -6.5 | 7.2e-11 | -0.57 | 0.06 | 0.07 | FALSE |
11 | GTEx | Cells EBV-transformed lymphocytes | TGM1 | 0.24 | 0.16 | enet | 6 | 0.16 | 6.2e-06 | 5.22 | 6.5 | 1.0e-10 | 0.56 | 0.69 | 0.04 | FALSE |
12 | GTEx | Cells Transformed fibroblasts | LTB4R | 0.12 | 0.09 | lasso | 2 | 0.06 | 4.1e-05 | 5.98 | -6.1 | 1.1e-09 | -0.53 | 0.88 | 0.05 | FALSE |
13 | GTEx | Colon Sigmoid | TGM1 | 0.28 | 0.11 | lasso | 8 | 0.19 | 3.3e-07 | 7.81 | 6.3 | 3.1e-10 | 0.53 | 0.50 | 0.18 | FALSE |
14 | GTEx | Colon Transverse | TGM1 | 0.20 | 0.03 | lasso | 7 | 0.02 | 2.7e-02 | 7.81 | 8.0 | 1.6e-15 | 0.61 | 0.25 | 0.51 | FALSE |
15 | GTEx | Colon Transverse | ADCY4 | 0.26 | -0.01 | lasso | 4 | 0.00 | 3.6e-01 | 8.64 | 5.5 | 3.2e-08 | 0.36 | 0.05 | 0.34 | FALSE |
16 | GTEx | Esophagus Mucosa | TGM1 | 0.14 | 0.03 | enet | 21 | 0.03 | 5.1e-03 | 7.79 | -7.5 | 7.3e-14 | -0.68 | 0.12 | 0.79 | FALSE |
17 | GTEx | Esophagus Mucosa | DHRS1 | 0.59 | 0.19 | lasso | 9 | 0.50 | 3.0e-38 | 7.81 | -5.3 | 1.5e-07 | -0.43 | 0.98 | 0.02 | FALSE |
18 | GTEx | Heart Atrial Appendage | ADCY4 | 0.28 | 0.14 | lasso | 4 | 0.10 | 2.1e-05 | 8.64 | 7.8 | 5.5e-15 | 0.48 | 0.06 | 0.86 | FALSE |
19 | GTEx | Heart Atrial Appendage | LTB4R | 0.17 | 0.02 | lasso | 2 | 0.06 | 8.6e-04 | 7.68 | -7.4 | 1.2e-13 | -0.47 | 0.31 | 0.24 | FALSE |
20 | GTEx | Heart Left Ventricle | CBLN3 | 0.35 | 0.23 | lasso | 8 | 0.21 | 1.5e-11 | 4.57 | -5.2 | 2.2e-07 | -0.16 | 1.00 | 0.00 | FALSE |
21 | GTEx | Lung | RABGGTA | 0.09 | 0.06 | lasso | 2 | 0.05 | 8.2e-05 | 7.82 | -7.5 | 5.0e-14 | -0.60 | 0.46 | 0.42 | FALSE |
22 | GTEx | Lung | LTB4R | 0.19 | 0.15 | lasso | 6 | 0.12 | 2.0e-09 | 7.79 | -8.5 | 2.2e-17 | -0.66 | 0.98 | 0.02 | FALSE |
23 | GTEx | Muscle Skeletal | CBLN3 | 0.14 | 0.13 | enet | 7 | 0.13 | 4.8e-13 | 4.47 | -5.1 | 2.8e-07 | -0.13 | 1.00 | 0.00 | FALSE |
24 | GTEx | Nerve Tibial | TGM1 | 0.25 | 0.12 | lasso | 6 | 0.16 | 1.0e-11 | 3.60 | 6.3 | 4.1e-10 | 0.52 | 0.99 | 0.01 | FALSE |
25 | GTEx | Nerve Tibial | LTB4R | 0.14 | 0.12 | lasso | 6 | 0.12 | 1.5e-08 | 7.81 | -6.4 | 1.8e-10 | -0.57 | 0.97 | 0.03 | FALSE |
26 | GTEx | Ovary | DHRS1 | 0.33 | 0.04 | lasso | 5 | 0.09 | 3.9e-03 | 5.98 | 5.3 | 1.1e-07 | 0.55 | 0.08 | 0.06 | FALSE |
27 | GTEx | Spleen | NFATC4 | 0.45 | 0.00 | enet | 24 | 0.00 | 2.5e-01 | 4.66 | -5.7 | 1.0e-08 | -0.22 | 0.07 | 0.06 | TRUE |
28 | GTEx | Testis | LTB4R | 0.42 | 0.27 | lasso | 12 | 0.27 | 1.5e-12 | 5.98 | -7.3 | 2.6e-13 | -0.60 | 0.98 | 0.02 | FALSE |
29 | GTEx | Thyroid | ADCY4 | 0.13 | 0.13 | lasso | 6 | 0.09 | 1.0e-07 | 7.28 | 8.6 | 1.1e-17 | 0.51 | 0.62 | 0.38 | FALSE |
30 | GTEx | Thyroid | LTB4R | 0.30 | 0.18 | lasso | 2 | 0.17 | 1.0e-12 | 7.79 | -7.8 | 7.8e-15 | -0.60 | 0.98 | 0.02 | FALSE |
31 | METSIM | Adipose | ADCY4 | 0.07 | 0.03 | lasso | 5 | 0.03 | 2.2e-05 | 8.51 | 8.9 | 6.4e-19 | 0.71 | 0.14 | 0.86 | TRUE |
32 | METSIM | Adipose | LTB4R | 0.15 | 0.07 | blup | 498 | 0.07 | 6.2e-11 | 7.68 | -6.4 | 1.6e-10 | -0.61 | 0.32 | 0.68 | FALSE |
33 | METSIM | Adipose | RABGGTA | 0.10 | 0.06 | lasso | 9 | 0.08 | 5.5e-12 | 6.71 | 5.6 | 2.4e-08 | 0.62 | 1.00 | 0.00 | FALSE |
34 | METSIM | Adipose | TGM1 | 0.18 | 0.15 | enet | 34 | 0.17 | 3.9e-24 | 5.22 | 6.6 | 3.6e-11 | 0.68 | 1.00 | 0.00 | FALSE |
35 | YFS | Blood | LTB4R | 0.02 | 0.00 | blup | 483 | 0.01 | 6.1e-03 | 6.71 | -7.3 | 2.5e-13 | -0.61 | 0.10 | 0.85 | FALSE |
36 | YFS | Blood | TGM1 | 0.05 | 0.04 | lasso | 5 | 0.05 | 2.2e-15 | 5.22 | 5.5 | 3.5e-08 | 0.54 | 1.00 | 0.00 | FALSE |
37 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ADCY4 | 0.03 | 0.01 | blup | 75 | 0.03 | 1.1e-03 | 7.84 | 8.8 | 1.5e-18 | 0.71 | 0.05 | 0.74 | FALSE |
38 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ADCY4 | 0.04 | 0.02 | blup | 75 | 0.04 | 3.8e-09 | 4.77 | 6.4 | 1.8e-10 | 0.61 | 0.40 | 0.60 | FALSE |
39 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | CBLN3 | 0.34 | 0.15 | lasso | 5 | 0.14 | 2.4e-07 | 4.84 | -5.2 | 1.9e-07 | -0.17 | 0.90 | 0.03 | FALSE |
40 | The Cancer Genome Atlas | Colon Adenocarcinoma | ADCY4 | 0.07 | 0.02 | lasso | 4 | 0.03 | 4.7e-03 | 6.20 | 7.5 | 5.0e-14 | 0.70 | 0.03 | 0.75 | FALSE |
41 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ADCY4 | 0.03 | 0.03 | enet | 5 | 0.03 | 6.9e-04 | 7.29 | 6.3 | 2.2e-10 | 0.53 | 0.23 | 0.37 | FALSE |
42 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADCY4 | 0.13 | 0.06 | enet | 20 | 0.09 | 2.8e-10 | 5.59 | 6.0 | 1.9e-09 | 0.57 | 0.15 | 0.85 | FALSE |
43 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADCY4 | 0.06 | 0.06 | lasso | 6 | 0.09 | 3.0e-10 | 7.23 | 8.8 | 1.7e-18 | 0.75 | 0.19 | 0.81 | FALSE |
44 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RABGGTA | 0.03 | 0.03 | lasso | 3 | 0.02 | 1.4e-03 | 7.82 | -7.8 | 8.6e-15 | -0.60 | 0.00 | 0.99 | FALSE |
45 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | DHRS1 | 0.19 | 0.01 | blup | 77 | 0.07 | 2.3e-04 | -0.54 | -5.6 | 2.0e-08 | -0.32 | 0.06 | 0.11 | FALSE |
46 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | TGM1 | 0.12 | 0.06 | blup | 61 | 0.04 | 4.3e-03 | -3.32 | 5.6 | 2.5e-08 | 0.31 | 0.40 | 0.10 | FALSE |
47 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADCY4 | 0.07 | 0.09 | lasso | 3 | 0.08 | 4.4e-10 | 7.68 | 8.7 | 3.7e-18 | 0.73 | 0.79 | 0.21 | FALSE |
48 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ADCY4 | 0.05 | 0.05 | lasso | 6 | 0.08 | 3.7e-09 | 5.06 | 6.4 | 1.8e-10 | 0.66 | 0.09 | 0.90 | FALSE |
49 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NYNRIN | 0.05 | 0.02 | blup | 81 | 0.02 | 4.0e-03 | 7.86 | 6.9 | 6.9e-12 | 0.65 | 0.05 | 0.66 | FALSE |
50 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RABGGTA | 0.07 | 0.03 | lasso | 3 | 0.03 | 5.3e-04 | 5.22 | -5.9 | 3.5e-09 | -0.54 | 0.16 | 0.29 | FALSE |
51 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LTB4R | 0.16 | 0.05 | blup | 73 | 0.08 | 4.9e-04 | 5.98 | -8.0 | 1.5e-15 | -0.70 | 0.02 | 0.59 | FALSE |
52 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LTB4R2 | 0.04 | 0.00 | blup | 76 | 0.02 | 2.9e-03 | 7.31 | -6.4 | 1.6e-10 | -0.57 | 0.04 | 0.17 | FALSE |
53 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LTB4R | 0.04 | 0.01 | blup | 73 | 0.01 | 4.2e-02 | 7.31 | -6.8 | 1.1e-11 | -0.63 | 0.01 | 0.45 | FALSE |
54 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LTB4R2 | 0.04 | 0.04 | lasso | 1 | 0.02 | 2.5e-02 | 7.31 | -7.3 | 2.7e-13 | -0.70 | 0.04 | 0.51 | FALSE |
55 | The Cancer Genome Atlas | Thyroid Carcinoma | ADCY4 | 0.12 | 0.10 | blup | 75 | 0.12 | 3.6e-12 | -3.77 | 5.6 | 2.0e-08 | 0.53 | 1.00 | 0.00 | FALSE |
56 | The Cancer Genome Atlas | Thyroid Carcinoma | LTB4R | 0.08 | 0.05 | lasso | 8 | 0.05 | 1.7e-05 | 7.84 | -7.2 | 4.4e-13 | -0.58 | 0.61 | 0.19 | FALSE |
57 | The Cancer Genome Atlas | Thyroid Carcinoma | NFATC4 | 0.04 | 0.02 | blup | 66 | 0.02 | 1.1e-02 | 5.59 | -6.6 | 4.2e-11 | -0.60 | 0.04 | 0.43 | FALSE |
58 | The Cancer Genome Atlas | Thyroid Carcinoma | RABGGTA | 0.04 | 0.00 | enet | 11 | 0.01 | 1.4e-02 | 7.84 | -6.2 | 5.6e-10 | -0.58 | 0.01 | 0.94 | FALSE |