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chr14:24,020,127-25,593,857

Best TWAS P=6.4e-19 · Best GWAS P=1.8e-19 conditioned to 0.0301

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
31	METSIM	Adipose	ADCY4	0.07	0.03	lasso	5	0.03	2.2e-05	8.51	8.9	6.4e-19	0.71	0.14	0.86	TRUE
27	GTEx	Spleen	NFATC4	0.45	0.00	enet	24	0.00	2.5e-01	4.66	-5.7	1.0e-08	-0.22	0.07	0.06	TRUE
37	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ADCY4	0.03	0.01	blup	75	0.03	1.1e-03	7.84	8.8	1.5e-18	0.71	0.05	0.74	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADCY4	0.06	0.06	lasso	6	0.09	3.0e-10	7.23	8.8	1.7e-18	0.75	0.19	0.81	FALSE
47	The Cancer Genome Atlas	Lung Adenocarcinoma	ADCY4	0.07	0.09	lasso	3	0.08	4.4e-10	7.68	8.7	3.7e-18	0.73	0.79	0.21	FALSE
29	GTEx	Thyroid	ADCY4	0.13	0.13	lasso	6	0.09	1.0e-07	7.28	8.6	1.1e-17	0.51	0.62	0.38	FALSE
22	GTEx	Lung	LTB4R	0.19	0.15	lasso	6	0.12	2.0e-09	7.79	-8.5	2.2e-17	-0.66	0.98	0.02	FALSE
2	GTEx	Adipose Subcutaneous	ADCY4	0.08	0.04	lasso	3	0.03	3.3e-03	7.79	8.4	5.1e-17	0.62	0.21	0.22	FALSE
51	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LTB4R	0.16	0.05	blup	73	0.08	4.9e-04	5.98	-8.0	1.5e-15	-0.70	0.02	0.59	FALSE
14	GTEx	Colon Transverse	TGM1	0.20	0.03	lasso	7	0.02	2.7e-02	7.81	8.0	1.6e-15	0.61	0.25	0.51	FALSE
18	GTEx	Heart Atrial Appendage	ADCY4	0.28	0.14	lasso	4	0.10	2.1e-05	8.64	7.8	5.5e-15	0.48	0.06	0.86	FALSE
3	GTEx	Adipose Subcutaneous	LTB4R	0.14	0.12	lasso	3	0.12	1.3e-09	7.79	-7.8	6.3e-15	-0.61	0.95	0.05	FALSE
30	GTEx	Thyroid	LTB4R	0.30	0.18	lasso	2	0.17	1.0e-12	7.79	-7.8	7.8e-15	-0.60	0.98	0.02	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	RABGGTA	0.03	0.03	lasso	3	0.02	1.4e-03	7.82	-7.8	8.6e-15	-0.60	0.00	0.99	FALSE
8	GTEx	Breast Mammary Tissue	LTB4R	0.30	0.18	lasso	4	0.16	2.3e-08	7.68	-7.7	1.8e-14	-0.63	0.70	0.29	FALSE
21	GTEx	Lung	RABGGTA	0.09	0.06	lasso	2	0.05	8.2e-05	7.82	-7.5	5.0e-14	-0.60	0.46	0.42	FALSE
40	The Cancer Genome Atlas	Colon Adenocarcinoma	ADCY4	0.07	0.02	lasso	4	0.03	4.7e-03	6.20	7.5	5.0e-14	0.70	0.03	0.75	FALSE
16	GTEx	Esophagus Mucosa	TGM1	0.14	0.03	enet	21	0.03	5.1e-03	7.79	-7.5	7.3e-14	-0.68	0.12	0.79	FALSE
19	GTEx	Heart Atrial Appendage	LTB4R	0.17	0.02	lasso	2	0.06	8.6e-04	7.68	-7.4	1.2e-13	-0.47	0.31	0.24	FALSE
35	YFS	Blood	LTB4R	0.02	0.00	blup	483	0.01	6.1e-03	6.71	-7.3	2.5e-13	-0.61	0.10	0.85	FALSE
28	GTEx	Testis	LTB4R	0.42	0.27	lasso	12	0.27	1.5e-12	5.98	-7.3	2.6e-13	-0.60	0.98	0.02	FALSE
54	The Cancer Genome Atlas	Stomach Adenocarcinoma	LTB4R2	0.04	0.04	lasso	1	0.02	2.5e-02	7.31	-7.3	2.7e-13	-0.70	0.04	0.51	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	LTB4R	0.08	0.05	lasso	8	0.05	1.7e-05	7.84	-7.2	4.4e-13	-0.58	0.61	0.19	FALSE
49	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NYNRIN	0.05	0.02	blup	81	0.02	4.0e-03	7.86	6.9	6.9e-12	0.65	0.05	0.66	FALSE
53	The Cancer Genome Atlas	Stomach Adenocarcinoma	LTB4R	0.04	0.01	blup	73	0.01	4.2e-02	7.31	-6.8	1.1e-11	-0.63	0.01	0.45	FALSE
34	METSIM	Adipose	TGM1	0.18	0.15	enet	34	0.17	3.9e-24	5.22	6.6	3.6e-11	0.68	1.00	0.00	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	NFATC4	0.04	0.02	blup	66	0.02	1.1e-02	5.59	-6.6	4.2e-11	-0.60	0.04	0.43	FALSE
10	GTEx	Breast Mammary Tissue (Female)	LTB4R	0.12	0.02	lasso	2	0.01	2.1e-01	7.68	-6.5	7.2e-11	-0.57	0.06	0.07	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	TGM1	0.24	0.16	enet	6	0.16	6.2e-06	5.22	6.5	1.0e-10	0.56	0.69	0.04	FALSE
32	METSIM	Adipose	LTB4R	0.15	0.07	blup	498	0.07	6.2e-11	7.68	-6.4	1.6e-10	-0.61	0.32	0.68	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	LTB4R2	0.04	0.00	blup	76	0.02	2.9e-03	7.31	-6.4	1.6e-10	-0.57	0.04	0.17	FALSE
9	GTEx	Breast Mammary Tissue (Male)	LTB4R	0.26	0.06	lasso	4	0.03	6.7e-02	5.98	-6.4	1.7e-10	-0.53	0.06	0.15	FALSE
25	GTEx	Nerve Tibial	LTB4R	0.14	0.12	lasso	6	0.12	1.5e-08	7.81	-6.4	1.8e-10	-0.57	0.97	0.03	FALSE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADCY4	0.04	0.02	blup	75	0.04	3.8e-09	4.77	6.4	1.8e-10	0.61	0.40	0.60	FALSE
48	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ADCY4	0.05	0.05	lasso	6	0.08	3.7e-09	5.06	6.4	1.8e-10	0.66	0.09	0.90	FALSE
41	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ADCY4	0.03	0.03	enet	5	0.03	6.9e-04	7.29	6.3	2.2e-10	0.53	0.23	0.37	FALSE
1	CommonMind	Brain Pre-frontal Cortex	NFATC4	0.07	0.04	blup	538	0.03	8.5e-05	5.59	-6.3	2.7e-10	-0.42	0.15	0.72	FALSE
13	GTEx	Colon Sigmoid	TGM1	0.28	0.11	lasso	8	0.19	3.3e-07	7.81	6.3	3.1e-10	0.53	0.50	0.18	FALSE
24	GTEx	Nerve Tibial	TGM1	0.25	0.12	lasso	6	0.16	1.0e-11	3.60	6.3	4.1e-10	0.52	0.99	0.01	FALSE
7	GTEx	Brain Hippocampus	ADCY4	0.35	0.03	lasso	10	0.07	1.1e-02	7.28	6.2	5.4e-10	0.49	0.07	0.23	FALSE
58	The Cancer Genome Atlas	Thyroid Carcinoma	RABGGTA	0.04	0.00	enet	11	0.01	1.4e-02	7.84	-6.2	5.6e-10	-0.58	0.01	0.94	FALSE
12	GTEx	Cells Transformed fibroblasts	LTB4R	0.12	0.09	lasso	2	0.06	4.1e-05	5.98	-6.1	1.1e-09	-0.53	0.88	0.05	FALSE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ADCY4	0.13	0.06	enet	20	0.09	2.8e-10	5.59	6.0	1.9e-09	0.57	0.15	0.85	FALSE
50	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RABGGTA	0.07	0.03	lasso	3	0.03	5.3e-04	5.22	-5.9	3.5e-09	-0.54	0.16	0.29	FALSE
45	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	DHRS1	0.19	0.01	blup	77	0.07	2.3e-04	-0.54	-5.6	2.0e-08	-0.32	0.06	0.11	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	ADCY4	0.12	0.10	blup	75	0.12	3.6e-12	-3.77	5.6	2.0e-08	0.53	1.00	0.00	FALSE
33	METSIM	Adipose	RABGGTA	0.10	0.06	lasso	9	0.08	5.5e-12	6.71	5.6	2.4e-08	0.62	1.00	0.00	FALSE
46	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TGM1	0.12	0.06	blup	61	0.04	4.3e-03	-3.32	5.6	2.5e-08	0.31	0.40	0.10	FALSE
15	GTEx	Colon Transverse	ADCY4	0.26	-0.01	lasso	4	0.00	3.6e-01	8.64	5.5	3.2e-08	0.36	0.05	0.34	FALSE
4	GTEx	Artery Aorta	LTB4R	0.27	0.01	lasso	11	0.03	6.4e-03	5.98	-5.5	3.5e-08	-0.50	0.63	0.06	FALSE
36	YFS	Blood	TGM1	0.05	0.04	lasso	5	0.05	2.2e-15	5.22	5.5	3.5e-08	0.54	1.00	0.00	FALSE
6	GTEx	Brain Cortex	TGM1	0.35	0.09	lasso	12	0.06	8.4e-03	5.22	5.4	7.1e-08	0.59	0.17	0.44	FALSE
26	GTEx	Ovary	DHRS1	0.33	0.04	lasso	5	0.09	3.9e-03	5.98	5.3	1.1e-07	0.55	0.08	0.06	FALSE
17	GTEx	Esophagus Mucosa	DHRS1	0.59	0.19	lasso	9	0.50	3.0e-38	7.81	-5.3	1.5e-07	-0.43	0.98	0.02	FALSE
39	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CBLN3	0.34	0.15	lasso	5	0.14	2.4e-07	4.84	-5.2	1.9e-07	-0.17	0.90	0.03	FALSE
20	GTEx	Heart Left Ventricle	CBLN3	0.35	0.23	lasso	8	0.21	1.5e-11	4.57	-5.2	2.2e-07	-0.16	1.00	0.00	FALSE
23	GTEx	Muscle Skeletal	CBLN3	0.14	0.13	enet	7	0.13	4.8e-13	4.47	-5.1	2.8e-07	-0.13	1.00	0.00	FALSE
5	GTEx	Artery Coronary	CBLN3	0.52	0.20	lasso	7	0.24	9.7e-09	4.57	-5.1	2.9e-07	-0.12	0.96	0.01	FALSE