[Hub]/) : Traits : Comparative height size at age 10 :

chr14:24,020,127-25,593,857

Best TWAS P=6.4e-19 · Best GWAS P=1.8e-19 conditioned to 0.0301

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex NFATC4 0.07 0.04 blup 538 0.03 8.5e-05 5.59 -6.3 2.7e-10 -0.42 0.15 0.72 FALSE
2 GTEx Adipose Subcutaneous ADCY4 0.08 0.04 lasso 3 0.03 3.3e-03 7.79 8.4 5.1e-17 0.62 0.21 0.22 FALSE
3 GTEx Adipose Subcutaneous LTB4R 0.14 0.12 lasso 3 0.12 1.3e-09 7.79 -7.8 6.3e-15 -0.61 0.95 0.05 FALSE
4 GTEx Artery Aorta LTB4R 0.27 0.01 lasso 11 0.03 6.4e-03 5.98 -5.5 3.5e-08 -0.50 0.63 0.06 FALSE
5 GTEx Artery Coronary CBLN3 0.52 0.20 lasso 7 0.24 9.7e-09 4.57 -5.1 2.9e-07 -0.12 0.96 0.01 FALSE
6 GTEx Brain Cortex TGM1 0.35 0.09 lasso 12 0.06 8.4e-03 5.22 5.4 7.1e-08 0.59 0.17 0.44 FALSE
7 GTEx Brain Hippocampus ADCY4 0.35 0.03 lasso 10 0.07 1.1e-02 7.28 6.2 5.4e-10 0.49 0.07 0.23 FALSE
8 GTEx Breast Mammary Tissue LTB4R 0.30 0.18 lasso 4 0.16 2.3e-08 7.68 -7.7 1.8e-14 -0.63 0.70 0.29 FALSE
9 GTEx Breast Mammary Tissue (Male) LTB4R 0.26 0.06 lasso 4 0.03 6.7e-02 5.98 -6.4 1.7e-10 -0.53 0.06 0.15 FALSE
10 GTEx Breast Mammary Tissue (Female) LTB4R 0.12 0.02 lasso 2 0.01 2.1e-01 7.68 -6.5 7.2e-11 -0.57 0.06 0.07 FALSE
11 GTEx Cells EBV-transformed lymphocytes TGM1 0.24 0.16 enet 6 0.16 6.2e-06 5.22 6.5 1.0e-10 0.56 0.69 0.04 FALSE
12 GTEx Cells Transformed fibroblasts LTB4R 0.12 0.09 lasso 2 0.06 4.1e-05 5.98 -6.1 1.1e-09 -0.53 0.88 0.05 FALSE
13 GTEx Colon Sigmoid TGM1 0.28 0.11 lasso 8 0.19 3.3e-07 7.81 6.3 3.1e-10 0.53 0.50 0.18 FALSE
14 GTEx Colon Transverse TGM1 0.20 0.03 lasso 7 0.02 2.7e-02 7.81 8.0 1.6e-15 0.61 0.25 0.51 FALSE
15 GTEx Colon Transverse ADCY4 0.26 -0.01 lasso 4 0.00 3.6e-01 8.64 5.5 3.2e-08 0.36 0.05 0.34 FALSE
16 GTEx Esophagus Mucosa TGM1 0.14 0.03 enet 21 0.03 5.1e-03 7.79 -7.5 7.3e-14 -0.68 0.12 0.79 FALSE
17 GTEx Esophagus Mucosa DHRS1 0.59 0.19 lasso 9 0.50 3.0e-38 7.81 -5.3 1.5e-07 -0.43 0.98 0.02 FALSE
18 GTEx Heart Atrial Appendage ADCY4 0.28 0.14 lasso 4 0.10 2.1e-05 8.64 7.8 5.5e-15 0.48 0.06 0.86 FALSE
19 GTEx Heart Atrial Appendage LTB4R 0.17 0.02 lasso 2 0.06 8.6e-04 7.68 -7.4 1.2e-13 -0.47 0.31 0.24 FALSE
20 GTEx Heart Left Ventricle CBLN3 0.35 0.23 lasso 8 0.21 1.5e-11 4.57 -5.2 2.2e-07 -0.16 1.00 0.00 FALSE
21 GTEx Lung RABGGTA 0.09 0.06 lasso 2 0.05 8.2e-05 7.82 -7.5 5.0e-14 -0.60 0.46 0.42 FALSE
22 GTEx Lung LTB4R 0.19 0.15 lasso 6 0.12 2.0e-09 7.79 -8.5 2.2e-17 -0.66 0.98 0.02 FALSE
23 GTEx Muscle Skeletal CBLN3 0.14 0.13 enet 7 0.13 4.8e-13 4.47 -5.1 2.8e-07 -0.13 1.00 0.00 FALSE
24 GTEx Nerve Tibial TGM1 0.25 0.12 lasso 6 0.16 1.0e-11 3.60 6.3 4.1e-10 0.52 0.99 0.01 FALSE
25 GTEx Nerve Tibial LTB4R 0.14 0.12 lasso 6 0.12 1.5e-08 7.81 -6.4 1.8e-10 -0.57 0.97 0.03 FALSE
26 GTEx Ovary DHRS1 0.33 0.04 lasso 5 0.09 3.9e-03 5.98 5.3 1.1e-07 0.55 0.08 0.06 FALSE
27 GTEx Spleen NFATC4 0.45 0.00 enet 24 0.00 2.5e-01 4.66 -5.7 1.0e-08 -0.22 0.07 0.06 TRUE
28 GTEx Testis LTB4R 0.42 0.27 lasso 12 0.27 1.5e-12 5.98 -7.3 2.6e-13 -0.60 0.98 0.02 FALSE
29 GTEx Thyroid ADCY4 0.13 0.13 lasso 6 0.09 1.0e-07 7.28 8.6 1.1e-17 0.51 0.62 0.38 FALSE
30 GTEx Thyroid LTB4R 0.30 0.18 lasso 2 0.17 1.0e-12 7.79 -7.8 7.8e-15 -0.60 0.98 0.02 FALSE
31 METSIM Adipose ADCY4 0.07 0.03 lasso 5 0.03 2.2e-05 8.51 8.9 6.4e-19 0.71 0.14 0.86 TRUE
32 METSIM Adipose LTB4R 0.15 0.07 blup 498 0.07 6.2e-11 7.68 -6.4 1.6e-10 -0.61 0.32 0.68 FALSE
33 METSIM Adipose RABGGTA 0.10 0.06 lasso 9 0.08 5.5e-12 6.71 5.6 2.4e-08 0.62 1.00 0.00 FALSE
34 METSIM Adipose TGM1 0.18 0.15 enet 34 0.17 3.9e-24 5.22 6.6 3.6e-11 0.68 1.00 0.00 FALSE
35 YFS Blood LTB4R 0.02 0.00 blup 483 0.01 6.1e-03 6.71 -7.3 2.5e-13 -0.61 0.10 0.85 FALSE
36 YFS Blood TGM1 0.05 0.04 lasso 5 0.05 2.2e-15 5.22 5.5 3.5e-08 0.54 1.00 0.00 FALSE
37 The Cancer Genome Atlas Bladder Urothelial Carcinoma ADCY4 0.03 0.01 blup 75 0.03 1.1e-03 7.84 8.8 1.5e-18 0.71 0.05 0.74 FALSE
38 The Cancer Genome Atlas Breast Invasive Carcinoma ADCY4 0.04 0.02 blup 75 0.04 3.8e-09 4.77 6.4 1.8e-10 0.61 0.40 0.60 FALSE
39 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CBLN3 0.34 0.15 lasso 5 0.14 2.4e-07 4.84 -5.2 1.9e-07 -0.17 0.90 0.03 FALSE
40 The Cancer Genome Atlas Colon Adenocarcinoma ADCY4 0.07 0.02 lasso 4 0.03 4.7e-03 6.20 7.5 5.0e-14 0.70 0.03 0.75 FALSE
41 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ADCY4 0.03 0.03 enet 5 0.03 6.9e-04 7.29 6.3 2.2e-10 0.53 0.23 0.37 FALSE
42 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ADCY4 0.13 0.06 enet 20 0.09 2.8e-10 5.59 6.0 1.9e-09 0.57 0.15 0.85 FALSE
43 The Cancer Genome Atlas Brain Lower Grade Glioma ADCY4 0.06 0.06 lasso 6 0.09 3.0e-10 7.23 8.8 1.7e-18 0.75 0.19 0.81 FALSE
44 The Cancer Genome Atlas Brain Lower Grade Glioma RABGGTA 0.03 0.03 lasso 3 0.02 1.4e-03 7.82 -7.8 8.6e-15 -0.60 0.00 0.99 FALSE
45 The Cancer Genome Atlas Liver Hepatocellular Carcinoma DHRS1 0.19 0.01 blup 77 0.07 2.3e-04 -0.54 -5.6 2.0e-08 -0.32 0.06 0.11 FALSE
46 The Cancer Genome Atlas Liver Hepatocellular Carcinoma TGM1 0.12 0.06 blup 61 0.04 4.3e-03 -3.32 5.6 2.5e-08 0.31 0.40 0.10 FALSE
47 The Cancer Genome Atlas Lung Adenocarcinoma ADCY4 0.07 0.09 lasso 3 0.08 4.4e-10 7.68 8.7 3.7e-18 0.73 0.79 0.21 FALSE
48 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ADCY4 0.05 0.05 lasso 6 0.08 3.7e-09 5.06 6.4 1.8e-10 0.66 0.09 0.90 FALSE
49 The Cancer Genome Atlas Lung Squamous Cell Carcinoma NYNRIN 0.05 0.02 blup 81 0.02 4.0e-03 7.86 6.9 6.9e-12 0.65 0.05 0.66 FALSE
50 The Cancer Genome Atlas Lung Squamous Cell Carcinoma RABGGTA 0.07 0.03 lasso 3 0.03 5.3e-04 5.22 -5.9 3.5e-09 -0.54 0.16 0.29 FALSE
51 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma LTB4R 0.16 0.05 blup 73 0.08 4.9e-04 5.98 -8.0 1.5e-15 -0.70 0.02 0.59 FALSE
52 The Cancer Genome Atlas Prostate Adenocarcinoma LTB4R2 0.04 0.00 blup 76 0.02 2.9e-03 7.31 -6.4 1.6e-10 -0.57 0.04 0.17 FALSE
53 The Cancer Genome Atlas Stomach Adenocarcinoma LTB4R 0.04 0.01 blup 73 0.01 4.2e-02 7.31 -6.8 1.1e-11 -0.63 0.01 0.45 FALSE
54 The Cancer Genome Atlas Stomach Adenocarcinoma LTB4R2 0.04 0.04 lasso 1 0.02 2.5e-02 7.31 -7.3 2.7e-13 -0.70 0.04 0.51 FALSE
55 The Cancer Genome Atlas Thyroid Carcinoma ADCY4 0.12 0.10 blup 75 0.12 3.6e-12 -3.77 5.6 2.0e-08 0.53 1.00 0.00 FALSE
56 The Cancer Genome Atlas Thyroid Carcinoma LTB4R 0.08 0.05 lasso 8 0.05 1.7e-05 7.84 -7.2 4.4e-13 -0.58 0.61 0.19 FALSE
57 The Cancer Genome Atlas Thyroid Carcinoma NFATC4 0.04 0.02 blup 66 0.02 1.1e-02 5.59 -6.6 4.2e-11 -0.60 0.04 0.43 FALSE
58 The Cancer Genome Atlas Thyroid Carcinoma RABGGTA 0.04 0.00 enet 11 0.01 1.4e-02 7.84 -6.2 5.6e-10 -0.58 0.01 0.94 FALSE