Hub : Genes

NYNRIN

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1630	0.0520	0.00046	0.055	0.025	0.086	0.072	0.097	2.5e-07	0.00041	1.4e-10	3.7e-09	7.4e-12
2	GTEx	Brain Hypothalamus	0.4290	0.1500	0.00750	0.023	NA	0.038	NA	0.050	9.6e-02	NA	4.6e-02	NA	2.6e-02
3	GTEx	Pituitary	0.4650	0.1140	0.00490	0.023	NA	-0.008	NA	0.027	8.6e-02	NA	5.9e-01	NA	7.1e-02
4	GTEx	Skin Sun Exposed Lower leg	0.1440	0.0530	0.00290	0.131	NA	0.118	NA	0.115	5.7e-11	NA	5.9e-10	NA	9.8e-10
5	TCGA	Lung Squamous Cell Carcinoma	0.0545	0.0263	0.00370	0.016	0.017	0.005	NA	0.011	4.9e-03	0.00400	7.5e-02	NA	1.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.4	2.2	4.1	1.7	0.8	-0.5	1.9	2.0
Bipolar Disorder or Schizophrenia	0.4	0.9	2.3	1.2	0.2	0.1	0.8	1.5
Depressed Affect (Nagel 2018)	1.1	2.4	5.8	1.4	1.2	-2.4	0.7	1.5
Depression (Nagel 2018)	0.2	0.3	0.7	0.6	0.6	-0.8	-0.1	0.1
Intelligence (Savage-Jansen 2018)	0.3	1.1	2.6	-0.2	-1.6	-0.3	-1.1	1.2
Neuroticism (Nagel 2018)	1.0	2.4	5.2	2.3	1.5	-1.7	1.0	0.7
Schizophrenia (2018)	0.0	0.1	0.2	0.2	-0.1	0.5	-0.3	0.3
Schizophrenia vs Biploar Disorder	0.5	0.7	1.3	-0.9	-0.5	0.9	-0.6	-1.1
Worry (Nagel 2018)	0.4	0.8	3.4	1.8	0.4	-0.7	0.2	-0.1
Alzheimer’s Disease (in mother)	0.7	0.8	1.5	1.0	-1.0	1.2	0.9	0.4
Alzheimer’s Disease (in father)	0.6	0.6	1.8	0.9	1.3	0.4	-0.2	-0.6
Alzheimer’s Disease (including proxy)	0.6	0.8	2.9	1.7	0.2	0.9	0.7	0.0
Crohns Disease (2017)	0.8	1.7	6.6	-1.0	-0.4	0.7	-0.2	-2.6
Irritable Bowel Disease (IBD)	0.4	1.1	3.6	-1.0	0.2	-0.8	-0.1	-1.9
Ulcerative Colitis (UC)	0.4	0.8	2.7	-0.9	0.3	-1.6	-0.4	0.0
Major Depression (MDD)	2.0	2.4	4.7	1.6	1.0	0.4	1.9	2.2
Reaction Time	0.6	1.1	4.0	-0.4	-2.0	-0.3	-1.1	0.2
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.2	-0.4	-0.6	-0.3	-1.5	1.0
Breast Cancer	0.8	1.9	4.0	-1.1	-0.7	-0.6	-2.0	-1.9
Ovarian Cancer	0.4	0.6	1.4	-0.8	0.5	0.2	-1.2	-0.7
Prostate Cancer	0.2	0.3	1.1	0.5	0.3	1.0	0.2	0.5
Age at First Birth	0.6	0.9	1.6	0.1	1.2	-0.7	-1.3	-0.9
Bipolar Disorder (2011)	0.4	0.4	1.0	0.0	0.5	-0.7	-1.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.2	0.3	-0.4	-0.3	-0.6	0.3	-0.3
Coronary Artery Disease (CAD)	0.3	0.4	1.4	-0.3	1.2	0.5	0.2	-0.5
Crohns Disease (2012)	1.9	3.1	11.7	-0.8	1.2	0.7	-1.1	-3.4
Mean Putamen Volume	0.5	0.6	1.7	-0.4	1.1	-1.3	0.0	-0.1
Fasting Glucose	0.4	0.4	0.8	0.6	0.9	-0.6	0.8	-0.2
HbA1C	0.2	0.2	0.5	-0.3	-0.2	-0.7	-0.5	-0.2
HDL Cholesterol	0.2	0.4	0.7	-0.4	0.4	0.6	-0.7	-0.8
LDL Cholesterol	8.8	13.9	30.2	-5.1	-1.0	-0.8	-5.5	-3.5
Lupus	0.6	0.9	1.6	0.7	-0.3	1.1	1.3	0.9
Neuroticism (2016)	0.5	0.8	1.5	0.1	-1.2	-1.1	-0.8	-0.6
Primary Biliary Cirrhosis	1.0	1.5	3.8	0.8	1.5	0.3	2.0	0.9
Rheumatoid Arthritis	1.1	1.5	5.2	0.2	-1.3	-2.3	-0.6	0.7
Schizophrenia (2014)	0.1	0.2	0.5	0.4	-0.4	0.7	0.1	0.2
Triglycerides	0.3	0.4	1.2	0.3	-1.1	0.1	-0.1	-0.9
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.9	-1.4	-1.2	-0.7	-0.5	0.0
Ulcerative Colitis	0.8	1.2	3.2	-0.5	1.8	-1.6	0.0	-0.2
Blood Eosinophil Count	0.1	0.6	1.5	-1.1	-1.2	0.2	-0.7	0.1
Blood Platelet Count	0.1	0.8	1.9	-0.5	-1.4	-0.5	-0.3	1.1
Blood Red Count	1.0	9.9	23.7	-4.9	-0.3	1.5	-3.4	-3.4
Blood White Count	0.8	6.0	17.3	1.8	1.8	-1.4	4.2	2.1
Heel T-Score	1.3	10.7	42.6	-0.7	-1.1	-1.2	-2.8	-6.5
BMI	0.2	1.3	3.8	-1.3	-1.0	-1.9	-0.1	0.4
Height	1.9	37.6	132.2	2.4	-2.1	-0.8	6.7	11.5
Waist Hip Ratio (WHR)	0.1	0.3	0.6	0.3	-0.6	0.4	0.7	0.6
Systolic Blood Pressure	0.4	2.0	5.7	-0.1	-1.1	-2.4	0.9	1.5
Smoking Status	1.1	2.7	7.5	-1.6	2.7	-1.6	-0.5	-0.7
Allergy or Eczema	0.4	1.0	4.2	0.5	-2.0	-0.7	-0.3	0.3
Cardiovascular Disease	0.7	2.3	4.0	-1.1	-1.7	-1.8	-0.6	2.0
Hypothyroidism (self reported)	0.3	0.7	2.2	0.4	0.2	-0.9	-0.1	1.5
Respiratory disease	0.3	0.6	1.1	0.1	-1.1	0.9	0.7	0.7
Type 2 Diabetes (T2D) (2018)	1.4	2.6	8.8	-3.0	-0.3	-1.2	-1.6	-0.5
Lung FEV1/FVC ratio	0.6	3.2	6.1	2.1	-0.5	-0.9	2.1	2.5
Lung FVC	0.1	0.6	1.1	-0.6	-0.2	-0.8	-1.0	-1.0
Neuroticism	0.5	1.2	2.5	1.6	-0.1	-1.5	0.3	1.1
Chronotype (morning person)	0.6	1.4	5.5	1.0	-2.3	-0.5	0.3	0.4
Hair Pigment	0.1	1.7	2.8	-1.2	0.3	-1.2	-1.6	-1.7
Tanning	0.0	0.3	0.8	0.5	0.6	0.4	0.9	-0.1
Hand grip strength (left)	0.6	1.6	3.4	-1.0	1.4	-1.1	-0.7	1.8
Number of treatments/medications taken	0.4	0.7	1.5	-1.1	-0.6	-0.2	-1.2	0.6
Average weekly spirits intake	0.1	0.1	0.3	0.1	-0.5	-0.5	0.2	-0.2
Sensitivity / hurt feelings	0.1	0.1	0.2	0.4	-0.4	-0.3	-0.2	-0.1
Frequency of depressed mood in last 2 weeks	1.1	1.5	2.8	1.7	1.3	-1.4	1.0	0.4
Hearing difficulty/problems: Yes	0.7	1.1	3.3	0.8	-0.0	1.8	1.2	0.1
Relative age of first facial hair	4.5	9.2	27.6	-2.2	1.1	0.7	-3.5	-5.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.6	0.4	-0.6	0.4	1.3	0.8
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.2	-1.5	0.5	-0.9	-0.7	1.8
Ever had hysterectomy (womb removed)	0.5	0.6	2.4	-0.3	0.2	0.6	0.2	1.5
Systolic blood pressure, automated reading	0.2	0.7	3.1	-0.4	-0.3	-1.8	0.0	-0.1
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	4.8	-2.2	-0.5	0.4	-1.4	-1.3
Angina	1.3	1.8	4.7	-1.1	-1.5	2.2	-0.7	-0.0
Medication for hormone replacement therapy	0.9	1.0	1.4	-0.9	-0.9	0.9	-1.0	1.2
Vitamin and mineral supplements	1.8	2.5	4.2	-2.0	0.9	1.5	-1.7	-1.4
Supplements: Zinc	2.5	2.8	5.3	0.9	-1.0	2.2	1.3	2.3
Medication: Co-codamol	0.8	1.0	3.9	-0.0	-0.2	2.0	0.2	0.9
Medication: Metformin	1.6	2.2	4.1	-2.0	0.2	-1.5	-2.0	-0.7
Diabetes (father)	0.5	0.7	2.0	-0.9	-0.1	-1.4	-0.4	-0.4
Diabetes (mother)	2.2	2.8	7.3	-2.7	-0.0	-0.1	-2.5	-0.4
Severe depression (siblings)	0.9	1.0	2.1	1.0	0.7	0.6	1.0	-1.5
Pack years adult smoking proportion	0.6	1.0	1.9	-1.4	-0.9	-1.4	-0.5	0.1
Impedance of leg (right)	0.1	0.6	2.1	-0.2	0.2	1.5	-0.9	-0.1
Leg fat-free mass (left)	1.1	5.8	17.6	0.3	-0.8	-1.5	2.9	4.2
Trunk fat percentage	0.4	1.6	5.1	-0.4	-0.9	-0.2	1.4	2.3
Hand grip strength (right)	0.5	1.2	2.1	-1.5	0.1	-1.3	-0.6	1.4
Townsend deprivation index at recruitment	0.7	0.9	3.9	-2.0	0.1	0.1	-0.6	-0.6
Current tobacco smoking	0.5	0.7	1.8	-1.4	-0.1	-1.1	-0.8	0.2
Average weekly fortified wine intake	0.4	0.4	1.0	1.0	0.9	-0.2	0.0	-0.4
Maternal smoking around birth	0.4	0.6	2.1	-1.5	0.6	-0.6	-0.3	-0.4
Fed-up feelings	0.4	0.7	2.2	0.5	-0.1	-0.9	0.5	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.0	-0.3	-1.0	-0.8	-0.6	-0.2
Relative age voice broke	1.3	2.0	3.9	-0.9	0.6	1.4	-1.8	-2.0
Taking other prescription medications	0.8	1.2	2.2	-1.2	-1.1	0.9	-1.5	-0.5
Age when periods started (menarche)	1.0	2.4	7.7	-0.5	-1.3	0.6	-1.5	-2.8
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.7	-0.0	-0.0	-0.8	1.0	1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	8.7	0.3	-1.4	-1.7	-0.3	-3.0
Tinnitus: Yes, but not now, but have in the past	2.4	2.5	7.5	1.6	-0.7	0.6	1.3	2.7
Qualifications: CSEs or equivalent	0.8	1.1	2.9	1.7	1.0	-0.4	1.0	-0.5
Serious illness, injury or assault to yourself	0.8	0.9	1.7	0.8	-1.3	0.0	1.2	1.0
High blood pressure	0.7	1.9	4.5	0.1	-2.1	-0.8	0.9	1.9
Hayfever, allergic rhinitis or eczema	0.6	1.3	5.6	0.2	-2.4	-0.2	-0.6	0.7
Multivitamins +/- minerals	0.8	1.0	2.2	1.0	-1.5	-1.3	0.2	0.5
Stomach or abdominal pain in last month	0.7	0.9	2.1	-0.3	0.7	-1.4	0.9	1.1
Supplements: Glucosamine	0.8	1.0	2.3	-1.4	-0.4	-0.8	-1.5	-0.3
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.6	1.3	0.0	0.8	0.5	1.2
Medication: Atenolol	0.3	0.3	0.8	-0.2	-0.9	0.1	0.8	-0.2
Medication: Levothyroxine sodium	0.3	0.6	1.2	0.6	0.0	0.3	1.1	1.1
Sitting height	0.6	4.4	15.6	0.6	-0.0	-0.4	2.4	4.0
Chronic bronchitis/emphysema (father)	0.6	0.7	1.5	0.1	1.1	-1.2	0.9	0.2
High blood pressure (mother)	0.3	0.4	1.0	-1.0	-0.8	0.1	0.2	-0.3
Body mass index (BMI)	0.1	0.6	1.6	-1.3	-0.4	-1.1	0.1	0.2
Impedance of leg (left)	0.1	0.6	1.7	-0.3	0.0	1.3	-1.0	-0.3
Leg predicted mass (left)	1.1	5.9	17.7	0.4	-0.9	-1.5	2.9	4.2
Trunk fat mass	0.7	3.2	10.3	-0.3	-1.1	-0.6	2.0	3.2
Waist circumference	0.6	2.3	5.9	-1.0	-1.2	-1.5	1.0	2.4
Number of incorrect matches in round	0.2	0.4	1.3	-0.4	0.3	0.2	-0.7	-1.1
Past tobacco smoking	1.5	2.7	9.4	0.8	-3.1	1.2	-0.4	1.4
Alcohol usually taken with meals	0.6	1.0	3.6	0.7	1.9	0.7	0.5	0.4
Nervous feelings	0.2	0.3	0.6	0.8	-0.4	-0.4	-0.6	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	2.5	0.6	-1.6	-1.4	-0.1	-0.6
Hearing difficulty/problems with background noise	0.9	1.5	5.5	-0.2	-1.2	2.3	0.2	-0.3
Hair/balding pattern: Pattern 2	0.5	0.6	2.8	0.5	0.1	0.2	0.2	1.7
Had menopause	0.1	0.1	0.2	-0.2	0.0	-0.4	-0.3	-0.3
Had other major operations	1.0	1.2	3.2	1.2	1.8	0.6	0.5	0.9
Forced vital capacity (FVC)	0.4	1.5	3.7	0.3	-0.4	-1.7	0.7	1.9
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	6.5	0.7	-1.4	-1.8	0.5	-2.5
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	4.1	1.3	-0.8	-1.3	1.6	2.0
Qualifications: None of the above	0.5	1.2	4.0	-2.0	-0.4	-0.9	-0.8	-0.4
Financial difficulties in last 2 years	1.0	1.3	4.1	0.3	-2.0	0.7	-0.1	1.4
Mouth/teeth dental problems	0.8	1.2	2.8	0.4	0.7	1.7	0.3	1.6
Heart attack	0.6	0.7	1.5	-0.2	-1.2	0.9	1.0	0.5
Allergy	0.7	1.6	7.3	0.1	2.7	0.2	0.4	-0.6
Pain all over the body in last month	0.5	0.6	1.9	-0.4	0.3	1.4	0.5	-0.6
Diabetes (self-reported)	1.6	2.5	9.6	-3.1	-0.2	-0.7	-1.4	0.3
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	3.2	0.7	-1.8	1.8	0.1	1.0
Medication: Ramipril	1.2	1.6	5.6	-0.6	-2.4	0.8	0.3	1.1
Medication: Simvastatin	1.5	2.2	6.6	-2.1	-0.0	-0.3	-2.6	-0.3
Fluid intelligence score	0.4	0.7	1.5	0.1	-0.9	-0.2	-1.2	1.2
Illnesses of siblings	1.1	1.6	3.0	-0.5	1.6	1.7	-1.4	-0.3
Neuroticism score	0.6	1.3	3.1	1.4	-1.0	-1.8	-0.1	0.5
Weight	0.7	3.4	11.3	-0.8	-0.9	-1.0	1.8	3.4
Impedance of arm (right)	0.6	2.6	4.8	1.8	-0.0	2.2	1.4	1.7
Arm fat percentage (right)	0.2	0.7	2.0	-0.4	-0.3	-0.5	1.1	1.4
Trunk fat-free mass	0.9	5.1	17.1	-0.2	-1.1	-1.6	2.2	4.1
Hip circumference	0.5	2.3	6.4	-0.4	-0.5	-1.1	1.8	2.5
Time employed in main current job	0.5	0.6	1.0	0.5	1.0	0.8	0.9	-0.5
Alcohol intake versus 10 years previously	0.2	0.3	1.0	-1.0	-0.2	-0.7	0.3	0.1
Father’s age at death	0.3	0.4	0.8	0.5	0.6	0.3	-0.9	-0.7
Worrier / anxious feelings	0.4	0.7	2.7	1.6	-0.2	-0.8	-0.0	0.4
Frequency of tiredness / lethargy in last 2 weeks	1.8	3.0	7.0	2.2	-0.7	-0.6	1.5	2.7
Falls in the last year	1.4	1.9	3.6	1.9	-1.4	-0.1	1.8	0.7
Hair/balding pattern: Pattern 3	0.4	0.6	1.4	0.2	-1.0	0.1	0.8	1.2
Number of live births	0.3	0.5	1.1	0.0	0.3	-0.8	-1.1	0.7
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	6.1	1.0	0.0	-2.0	1.2	2.5
Pulse rate	0.4	0.6	1.3	0.6	-1.1	0.7	-0.4	-0.9
Happiness	3.1	3.7	5.7	2.1	2.0	-0.5	2.4	2.0
Noisy workplace	0.3	0.3	1.2	0.2	-0.5	0.1	1.1	0.6
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.3	1.5	1.0	-0.4	-0.1	-0.1
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	4.6	0.0	1.1	-2.1	-0.3	0.6
Mouth/teeth dental problems: Dentures	0.7	1.2	3.7	-1.0	-1.9	-0.7	0.6	0.4
Asthma	0.4	0.8	2.9	-0.2	-1.7	0.6	-0.7	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.9	-1.4	1.0	0.7	-1.0	-0.2
Medication: Cholesterol lowering	1.8	2.8	7.2	-2.4	-0.6	0.1	-2.7	0.7
Depression (self-reported)	0.3	0.3	0.7	0.8	0.4	-0.4	0.6	0.4
Medication: Lansoprazole	1.5	1.7	6.5	0.8	-0.9	2.5	0.2	0.6
Prospective memory result	0.1	0.1	0.2	0.0	0.4	-0.5	-0.1	0.4
Lung cancer (father)	0.6	0.6	2.4	-1.6	0.6	-0.4	0.4	-0.4
Illnesses of mother	0.4	0.4	0.7	0.6	0.8	0.5	-0.8	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	4.7	1.0	0.5	-2.2	1.3	2.2
Pulse wave Arterial Stiffness index	0.5	0.5	1.6	-0.9	0.3	-1.3	-0.0	0.4
Impedance of arm (left)	0.3	1.5	3.4	1.5	-0.0	1.9	0.8	1.1
Arm fat mass (right)	0.4	1.8	5.0	-0.6	-0.8	-1.1	1.4	2.2
Trunk predicted mass	0.9	5.0	16.5	-0.1	-1.1	-1.6	2.2	4.1
Standing height	1.4	13.9	51.1	1.0	-1.3	0.0	4.0	7.1
Length of working week for main job	0.4	0.4	1.5	0.5	0.4	1.2	-0.2	-0.3
Exposure to tobacco smoke at home	0.2	0.2	0.5	-0.7	0.2	-0.4	-0.1	0.7
Breastfed as a baby	1.1	1.3	3.6	1.1	0.6	1.1	-0.4	-1.9
Tense / ‘highly strung’	0.4	0.7	1.2	1.1	1.0	0.3	0.3	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.3	1.5	0.2	-0.7	1.0	0.9
Hair/balding pattern: Pattern 4	0.4	0.9	1.5	-0.1	1.2	1.1	0.0	-1.2
Birth weight of first child	0.9	1.6	5.6	-0.8	-0.1	-2.4	-1.1	-0.5
Peak expiratory flow (PEF)	1.4	3.2	7.3	0.9	0.4	-2.7	1.5	2.3
Pulse wave reflection index	0.7	0.9	1.8	-0.2	1.1	-1.3	0.7	0.8
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	0.7	-0.1	-0.4	0.3	-0.5
Loud music exposure frequency	1.2	1.3	2.4	1.6	-1.4	0.1	1.3	0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	0.6	1.0	-0.1	-0.2	0.3
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.4	0.5	0.8	-1.5	0.4	-1.5
Blood clot in the leg (DVT)	0.6	0.8	3.5	0.0	-0.4	-1.9	0.5	0.3
Medication: Paracetamol	0.3	0.5	1.6	0.7	-0.1	0.2	1.3	0.3
Headache pain in last month	1.4	2.5	4.6	1.8	0.4	-1.6	1.2	2.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.6	0.9	0.9	-0.1	1.0	-1.9
Glaucoma (self-reported)	0.6	0.8	2.4	-0.6	-0.0	1.6	-0.5	-0.9
Gout (self-reported)	2.1	2.9	6.0	1.6	-2.2	-0.6	1.0	2.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.6	0.7	0.4	-0.4	0.4	1.3
Medication: Amlodipine	0.7	1.0	2.5	-1.2	0.1	-0.1	-1.6	-1.1
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.7	-0.6	-1.3	0.1	-0.3	-0.9
Birth weight	1.1	2.4	5.3	-1.5	-0.4	-0.7	-2.3	-1.9
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.9	1.0	0.3	0.5	0.3	0.6
High blood pressure (siblings)	2.2	3.2	6.5	1.1	-1.4	-1.7	2.5	1.9
Forced vital capacity (FVC), Best measure	0.3	1.1	3.0	0.1	0.1	-1.7	0.3	1.5
Body fat percentage	0.2	1.0	2.7	-0.7	-0.4	-0.2	1.2	1.7
Leg fat percentage (right)	0.2	0.6	2.4	-1.6	0.5	-0.6	-0.0	0.3
Arm fat-free mass (right)	0.8	3.9	12.2	-0.7	-1.3	-1.7	1.6	3.5
Exposure to tobacco smoke outside home	0.6	0.8	2.9	0.2	-0.4	-1.7	0.1	0.8
Comparative body size at age 10	0.8	2.1	5.5	0.0	2.3	-1.8	0.4	-1.3
Number of full brothers	0.3	0.4	1.0	-0.9	0.1	0.3	-0.3	1.0
Worry too long after embarrassment	0.3	0.5	1.5	0.5	0.1	-1.2	-0.7	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.0	1.4	-0.8	0.6	0.8	-0.0
Wheeze or whistling in the chest in last year	1.1	1.9	8.6	-0.2	-2.9	-0.0	1.0	0.2
Number of children fathered	0.3	0.3	1.3	0.4	1.1	0.2	0.0	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.8	-1.4	0.6	-0.7	-1.9	-0.5
Age at first live birth	0.3	0.5	0.8	0.9	0.5	0.2	-0.8	-0.8
Pulse wave peak to peak time	0.5	0.6	1.8	0.9	-0.4	1.3	0.4	-0.0
Health satisfaction	0.7	0.9	1.8	1.0	1.3	1.1	0.2	0.9
Shortness of breath walking on level ground	1.5	1.8	3.4	1.2	-1.4	1.0	1.8	1.2
Qualifications: College or University degree	0.1	0.4	0.8	0.5	-0.4	-0.3	-0.9	0.8
Eye problems/disorders: None of the above	0.5	0.6	1.4	0.4	1.2	0.9	-0.7	0.3
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.7	-0.9	-0.9	-1.9	-0.4	-0.9
Emphysema/chronic bronchitis	2.2	2.5	8.4	0.6	-1.4	-0.3	2.9	1.3
Medication for pain relief, constipation, heartburn	0.1	0.2	0.5	0.2	-0.3	0.3	0.3	-0.7
Neck or shoulder pain in last month	0.4	0.5	1.1	0.9	-0.0	0.1	1.0	0.9
Medication: Blood pressure	1.0	1.7	5.7	-0.4	-1.6	0.0	0.5	2.4
Angina (self-reported)	1.4	1.8	3.5	-1.3	-1.7	1.9	-0.8	0.3
Migraine (self-reported)	1.2	1.4	4.0	0.9	-0.8	1.0	0.9	2.0
Medication: Ibuprofen	1.3	1.5	3.6	-1.9	1.4	0.2	-1.4	-0.3
Medication: Allopurinol	2.4	3.2	5.3	0.7	-2.2	-1.8	1.4	2.3
Medication: Omeprazole	0.7	0.8	1.6	0.9	1.1	0.6	0.4	1.3
Medication: Seretide 50 evohaler	0.4	0.5	0.9	1.0	0.7	-0.6	0.7	-0.2
Mean time to correctly identify matches	0.4	0.8	2.6	0.3	-1.6	0.5	-0.9	0.3
Heart disease (mother)	0.5	0.6	2.0	-0.3	-1.4	-0.9	-0.4	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.1	-0.9	0.8	0.1	-0.2	-1.1
Whole body fat mass	0.6	2.3	7.5	-0.6	-0.9	-0.3	1.7	2.7
Leg fat mass (right)	0.3	1.1	2.9	-1.1	-0.0	-0.8	0.9	1.7
Arm predicted mass (right)	0.7	3.8	9.8	-1.0	-1.5	-1.9	1.5	3.1
Pulse rate, automated reading	0.5	1.7	4.7	-0.6	-2.2	0.6	-1.8	0.2
Alcohol intake frequency.	0.3	0.7	2.7	-0.4	-1.6	-0.4	0.2	0.5
Comparative height size at age 10	2.5	13.8	47.1	1.7	-1.8	-0.5	4.0	6.9
Number of full sisters	0.5	0.6	1.8	0.8	-1.4	-0.4	0.5	-0.6
Suffer from ‘nerves’	0.5	0.8	1.4	1.1	0.0	0.8	-0.7	-1.2
Overall health rating	0.2	0.4	1.2	-0.4	-0.4	1.1	-0.3	0.6
Chest pain or discomfort	1.7	2.5	7.0	0.6	-0.5	-0.9	2.0	2.6
Had major operations	1.0	1.2	4.6	-0.8	-2.2	0.8	0.1	-0.2
Age at last live birth	0.6	0.9	2.8	1.7	0.8	-0.9	0.2	0.4
Family relationship satisfaction	0.6	0.7	2.1	0.7	-0.1	-0.9	1.4	-0.3
Leg pain on walking	0.7	0.9	2.3	0.1	-1.5	0.5	0.3	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.9	-0.7	0.4	-0.7	0.3	1.7
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.8	-0.6	-0.2	0.9	-0.4	-0.8
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	3.0	-1.7	0.7	0.5	-1.3	-1.4
Medication: Aspirin	0.8	1.0	3.2	-1.8	-0.2	-0.4	-1.1	-0.7
Supplements: Vitamin C	1.0	1.2	2.2	1.1	-1.5	-1.1	0.8	0.9
Knee pain experienced in last month	0.6	1.0	4.5	-0.5	-2.1	-0.2	-0.0	-0.3
Hypertension (Self-reported)	0.6	1.8	4.3	0.2	-1.9	-0.5	0.8	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.2	-1.0	1.0	-0.5	-1.3	1.8
Illnesses of father: Heart disease	1.0	1.4	3.1	1.1	-1.3	1.8	0.5	0.7
Illnesses of siblings: Diabetes	0.9	1.1	2.7	-0.4	-1.1	-1.6	0.6	1.1
Smoking status: Previous	1.1	1.7	4.3	-0.8	2.1	-0.6	0.6	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.5	-0.7	-0.5	-0.5	0.3	0.7
Whole body fat-free mass	1.0	5.7	18.2	0.0	-1.1	-1.6	2.5	4.3
Leg fat-free mass (right)	1.1	5.7	16.8	0.3	-1.0	-1.6	2.8	4.1
Arm fat percentage (left)	0.1	0.5	0.8	-0.7	-0.2	-0.7	0.7	0.9
Average weekly red wine intake	0.5	0.7	1.7	1.3	0.5	-0.9	0.6	-0.7
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.9	0.9	-0.2	0.6	-0.5	0.7
Mood swings	0.2	0.4	1.3	0.6	0.3	-1.1	0.5	0.0
Loneliness, isolation	0.8	1.0	2.9	-0.7	0.4	-1.7	-1.2	0.5
Long-standing illness, disability or infirmity	0.4	0.6	1.8	-0.8	-0.4	0.5	0.5	1.4
Ever had bowel cancer screening	0.9	1.1	2.3	0.1	-1.4	1.1	0.2	-1.5
Diabetes diagnosed by doctor	1.5	2.4	8.7	-2.9	-0.4	-0.2	-1.7	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.2	0.5	-0.6	-0.5	0.3	-1.5
Friendships satisfaction	0.5	0.7	1.4	0.6	0.2	-1.2	1.1	0.4
Qualifications: nursing, teaching	0.5	0.8	1.9	-1.4	0.2	0.7	-1.2	-0.6
Commuting to job workplace: Walk	0.7	0.7	2.9	-0.6	0.0	-0.2	-0.6	-1.7
Eye problems/disorders: Cataract	1.2	1.4	4.1	-0.1	-0.5	-1.6	0.2	-2.0
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	4.2	-0.2	0.6	-0.3	-1.1	-2.0
Medication for cholesterol	0.8	1.2	3.0	0.1	1.7	0.0	-0.5	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.4	-0.6	-0.3	0.2	-0.0	0.3
Back pain experienced in last month	0.7	1.0	3.1	0.9	0.8	-0.7	1.7	0.5
Mineral and other dietary supplements	0.5	0.6	2.8	-0.6	1.7	0.1	-0.1	0.3
Breast cancer (self-reported)	1.1	1.3	2.9	1.7	-0.8	-1.5	0.8	0.5
Asthma (self-reported)	0.4	0.9	2.8	-0.2	-1.7	1.1	-0.7	-0.3
Osteoporosis (self-reported)	1.0	1.2	2.7	1.6	0.4	0.5	1.5	0.9
Osteoarthritis (self-reported)	0.2	0.3	1.1	-0.6	-1.1	-0.1	0.2	-0.0
Medication: Aspirin	0.4	0.5	1.4	-1.2	0.1	-0.2	-0.9	-0.6
Medication: Gliclazide	3.7	4.2	9.1	-2.8	-1.0	0.6	-3.0	-1.5
Illnesses of father: None of the above (group 1)	0.5	0.6	1.6	-1.3	-0.2	0.3	0.3	-1.0
Smoking status: Current	0.6	1.0	2.5	-1.6	0.5	-0.9	-1.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.4	0.5	-0.3	-1.2	-0.1	0.2
Whole body water mass	1.0	5.8	18.8	0.1	-1.1	-1.6	2.5	4.3
Leg predicted mass (right)	1.1	5.7	16.6	0.3	-1.1	-1.6	2.9	4.1
Arm fat mass (left)	0.3	1.4	3.8	-0.8	-0.8	-0.8	1.1	1.9
Number of self-reported non-cancer illnesses	0.6	1.0	2.4	-0.3	-0.9	1.3	-0.2	1.6
Average weekly champagne plus white wine intake	0.4	0.5	1.2	0.5	-0.5	-1.1	-0.6	0.5
Miserableness	1.4	2.4	7.2	1.1	0.8	-2.7	1.3	1.1
Guilty feelings	0.4	0.6	1.8	1.4	0.0	-0.2	1.0	0.5
Wears glasses or contact lenses	0.1	0.2	0.3	0.3	0.3	-0.5	-0.2	-0.6
Ever taken oral contraceptive pill	0.3	0.4	0.7	-0.4	-0.9	0.5	-0.3	-0.8
Hearing aid user	0.5	0.6	1.6	-1.1	-1.3	-0.4	-0.1	-0.1
Mother’s age at death	1.0	1.3	2.1	1.2	1.4	-0.6	-0.9	-1.3
Financial situation satisfaction	0.5	0.7	2.6	0.3	0.4	0.2	0.7	1.6
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.5	0.4	-0.3	-0.6	-0.3	-1.6
Commuting to job workplace: Public transport	0.5	0.6	1.8	1.4	0.3	-0.3	-0.2	1.0
Eye problems/disorders: Glaucoma	1.0	1.2	2.3	-1.3	-1.0	0.6	-1.5	-0.8
Medication: Blood pressure	0.6	1.1	1.9	0.5	-0.4	-1.4	1.3	1.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.0	-0.4	0.1	-1.0	1.0	-0.5
Supplements: Fish oil (including cod liver oil)	0.6	0.7	2.3	1.0	-1.5	-0.3	0.5	0.0
High cholesterol (Self-reported)	3.6	6.4	18.2	-3.3	0.3	-0.7	-4.3	-1.6
Medication: Bendroflumethiazide	0.8	1.2	3.8	1.2	0.7	-0.7	1.9	0.2
Medication: Paracetamol	0.2	0.3	1.1	-0.0	0.2	0.2	1.0	0.4
Medication: Lisinopril	0.7	0.9	2.9	-0.5	-1.0	-0.2	0.4	1.7
Medication: Atorvastatin	0.9	1.1	3.3	-0.3	-1.8	0.7	-0.2	1.1
Illnesses of father: High blood pressure	0.6	0.7	1.3	0.9	-0.7	-0.5	-0.9	1.1
Alcohol drinker status: Never	0.7	0.8	3.8	0.1	-0.5	-2.0	0.1	0.4
Ever smoked	1.6	2.8	8.6	-0.8	2.9	-1.3	-0.1	-1.6
Basal metabolic rate	1.0	5.7	18.4	-0.1	-1.1	-1.5	2.5	4.3
Leg fat percentage (left)	0.2	0.7	2.8	-1.7	0.3	-0.9	-0.0	0.2
Arm fat-free mass (left)	0.8	4.0	13.4	-0.6	-1.4	-1.2	1.8	3.7
Number of operations (self-reported)	0.2	0.2	0.8	-0.0	0.5	0.1	0.4	0.9
Average weekly beer plus cider intake	0.4	0.6	1.0	-0.8	0.8	-0.9	0.1	1.0
Irritability	0.3	0.5	1.2	0.4	0.9	-0.4	1.1	-0.5
Risk taking	0.5	0.7	1.5	-0.8	-0.7	1.2	-0.8	0.0
Ever had prostate specific antigen (PSA) test	2.7	3.1	5.1	-1.0	0.8	-2.1	-2.0	-2.3
Fractured/broken bones in last 5 years	0.3	0.4	1.8	0.2	-1.3	0.3	-0.4	-0.4
Age started oral contraceptive pill	1.0	1.2	4.0	0.6	-2.0	1.2	0.2	-0.5
Diastolic blood pressure, automated reading	0.3	1.0	3.2	-0.2	0.9	-1.8	0.5	0.9
Ever depressed for a whole week	2.8	3.4	7.8	1.6	0.7	-2.8	2.1	1.5
Unable to work because of sickness or disability	0.6	0.8	1.5	-0.6	0.8	0.6	1.1	1.2
Commuting to job workplace: Cycle	0.8	1.0	2.1	0.5	-1.4	1.3	-0.0	-0.9
Myopia	0.1	0.2	0.8	0.9	-0.2	0.3	0.1	0.1
Vascular/heart problems diagnosed by doctor	0.7	1.9	6.4	-0.2	2.5	0.1	-0.9	-1.5
Cholesterol lowering medication	2.3	3.3	6.5	-2.2	-1.5	-0.7	-2.5	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.9	0.6	0.4	0.4	-0.3	1.0
Pain experienced in last month	0.6	1.0	2.7	-0.6	-0.3	0.2	-1.3	-1.7
Supplements: Calcium	0.9	1.0	2.6	0.4	-0.3	0.2	1.6	1.5
Basal cell carcinoma (self-reported)	1.8	2.1	5.8	2.4	-0.0	0.5	1.6	1.4
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.6	-0.4	-1.3	0.9	0.9	0.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.6	0.1	-0.4	-1.6	0.7	0.2
Heart disease (siblings)	0.6	0.8	1.6	-0.3	-0.7	-0.4	-1.2	-1.2
Alcohol drinker status: Previous	0.1	0.1	0.4	0.1	-0.6	-0.1	0.0	0.2
Pack years of smoking	1.1	1.6	3.3	-1.8	-1.3	-1.4	-0.9	-0.3
Impedance of whole body	0.2	1.1	4.0	0.9	-0.0	2.0	0.1	0.6
Leg fat mass (left)	0.3	1.1	2.7	-1.1	-0.3	-0.8	0.9	1.6
Arm predicted mass (left)	0.8	4.0	12.4	-0.7	-1.2	-1.6	1.8	3.5