Hub : Genes

GRHL1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.3740 0.1130 4.0e-03 0.114 NA 0.062 NA 0.128 3.0e-04 NA 6.5e-03 NA 1.3e-04
2 GTEx Esophagus Mucosa 0.1630 0.0480 1.0e-03 0.008 NA -0.002 NA 0.000 8.4e-02 NA 4.6e-01 NA 3.4e-01
3 GTEx Skin Not Sun Exposed Suprapubic 0.2430 0.0770 3.4e-03 0.094 NA 0.115 NA 0.168 7.6e-06 NA 7.1e-07 NA 1.6e-09
4 GTEx Skin Sun Exposed Lower leg 0.2800 0.0520 2.5e-08 0.165 NA 0.205 NA 0.198 1.4e-13 NA 8.2e-17 NA 2.9e-16
5 GTEx Thyroid 0.1480 0.0490 1.7e-03 0.037 NA 0.019 NA 0.012 8.0e-04 NA 1.2e-02 NA 3.9e-02
6 TCGA Colon Adenocarcinoma 0.1050 0.0450 3.7e-03 0.025 0.019 0.032 NA 0.019 1.3e-02 2.7e-02 6.1e-03 NA 2.7e-02
7 TCGA Kidney Renal Clear Cell Carcinoma 0.0522 0.0265 9.4e-03 -0.001 0.012 -0.001 NA -0.001 3.9e-01 1.4e-02 4.2e-01 NA 4.6e-01
8 TCGA Kidney Renal Papillary Cell Carcinoma 0.1830 0.0640 1.2e-05 0.038 0.125 0.113 NA 0.114 3.1e-03 1.3e-07 5.2e-07 NA 4.4e-07
9 TCGA Pheochromocytoma and Paraganglioma 0.1270 0.0570 2.4e-03 0.083 0.077 0.081 NA 0.091 3.5e-04 5.7e-04 3.9e-04 NA 1.9e-04
10 TCGA Prostate Adenocarcinoma 0.0515 0.0253 2.4e-03 0.047 0.023 0.018 NA 0.031 1.1e-05 1.8e-03 4.8e-03 NA 2.8e-04
11 TCGA Stomach Adenocarcinoma 0.0990 0.0490 3.9e-03 0.040 0.023 0.008 NA 0.014 6.4e-04 8.1e-03 7.5e-02 NA 3.2e-02
12 TCGA Testicular Germ Cell Tumors 0.2990 0.1170 3.6e-03 0.040 0.058 0.037 NA 0.053 1.5e-02 4.3e-03 1.8e-02 NA 5.8e-03
13 TCGA Thyroid Carcinoma 0.1160 0.0470 4.5e-05 0.067 0.049 0.057 NA 0.055 4.4e-07 1.6e-05 3.2e-06 NA 4.9e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bipolar Disorder (2018) 0.2 0.4 1.9 -0.3 0.4 -0.5 -0.4 0.4 -0.8 -1.4 -0.3 0.6 0.3 0.8 -0.6 0.0
Bipolar Disorder or Schizophrenia 0.3 0.7 3.8 0.7 2.0 0.0 0.4 1.2 -1.2 0.0 -0.2 -0.5 -0.9 0.6 -0.2 0.4
Depressed Affect (Nagel 2018) 0.8 1.7 7.9 0.5 1.4 -0.7 0.7 1.7 -2.8 -1.3 -0.3 -0.2 -1.3 -0.4 1.9 -0.8
Depression (Nagel 2018) 0.4 0.6 5.4 0.0 -0.5 -0.4 -0.1 0.9 -0.8 -0.1 0.7 0.1 -0.3 -0.2 2.3 0.4
Intelligence (Savage-Jansen 2018) 0.3 0.8 4.8 0.6 -0.8 0.3 0.2 -0.2 0.2 1.4 1.3 0.1 -0.1 -0.3 2.2 0.9
Neuroticism (Nagel 2018) 0.6 1.3 6.9 0.2 0.7 -1.1 0.2 0.9 -2.6 -1.1 0.0 1.0 -0.9 -0.7 2.0 -0.6
Schizophrenia (2018) 0.5 1.1 4.7 1.1 2.2 0.4 0.9 1.3 -1.0 1.2 0.0 -1.1 -1.4 0.0 0.2 0.5
Schizophrenia vs Biploar Disorder 0.6 0.8 2.4 1.2 0.9 0.9 0.6 1.0 0.1 1.4 0.1 -1.5 -1.1 0.2 0.7 0.4
Worry (Nagel 2018) 0.5 1.0 4.5 -0.5 0.4 -0.6 -0.1 -0.6 -2.1 -0.7 -0.3 1.6 -0.6 -1.4 1.0 -1.0
Alzheimer’s Disease (in mother) 0.5 0.6 1.4 -0.6 0.8 -0.1 0.8 -0.8 -1.2 -0.7 -0.4 0.2 -0.7 -0.7 -0.9 -1.0
Alzheimer’s Disease (in father) 0.5 0.6 1.4 1.2 0.6 0.5 0.8 0.3 -0.6 0.4 -0.3 -0.6 -1.2 -0.4 1.0 -1.0
Alzheimer’s Disease (including proxy) 0.3 0.5 1.7 0.4 0.8 -0.3 0.6 -0.1 -0.8 -0.6 -0.6 -0.4 -1.0 -0.5 0.4 -1.3
Crohns Disease (2017) 0.4 0.8 2.4 -0.8 -1.1 -1.6 -0.9 -0.1 1.3 -0.1 0.5 0.2 0.9 0.8 0.7 1.1
Irritable Bowel Disease (IBD) 0.6 1.4 6.0 -1.7 -2.4 -1.0 -0.6 0.8 0.6 0.7 1.3 1.6 1.1 0.4 -0.5 0.7
Ulcerative Colitis (UC) 0.6 1.2 5.3 -1.5 -2.3 -0.2 -0.2 0.7 -0.1 1.1 1.3 1.7 0.9 0.0 -0.8 0.1
Major Depression (MDD) 0.6 0.7 2.9 0.0 -1.1 -0.6 -0.3 1.2 -0.9 0.7 1.7 0.7 0.4 1.2 0.0 0.2
Reaction Time 0.4 0.7 3.2 -0.5 0.9 0.9 0.6 -0.9 -0.4 0.4 -0.7 0.3 -0.7 -1.1 -1.8 -0.7
Verbal and Numeric Reasoning (VNR) 0.3 0.8 4.6 1.3 0.3 0.9 1.1 0.0 -0.4 -0.0 0.5 -0.9 -1.0 0.3 2.1 0.4
Breast Cancer 4.4 10.7 22.9 0.7 -3.4 -4.0 -4.8 0.4 4.7 2.2 2.8 1.2 4.8 3.2 -2.0 3.7
Ovarian Cancer 0.5 0.6 3.7 -0.1 0.7 1.9 1.3 -1.0 0.2 0.1 -0.2 -0.3 -0.7 -0.3 -0.2 -0.6
Prostate Cancer 7.8 10.9 23.7 -1.2 4.9 2.9 4.3 -0.5 -4.0 -2.6 -4.0 -0.3 -4.3 -3.3 -2.9 -3.6
Age at First Birth 0.7 1.0 3.1 -0.8 -0.6 1.1 1.1 -1.7 -1.4 -1.8 -0.0 0.6 -0.3 0.4 -0.2 -1.3
Bipolar Disorder (2011) 1.9 1.9 6.9 0.0 0.0 0.0 0.0 0.0 -1.9 -2.6 -1.5 1.1 -1.1 -0.5 -1.7 -2.4
Body Mass Index (BMI) (2010) 0.5 0.7 2.6 1.0 0.9 0.4 0.6 1.1 0.9 1.0 -0.6 -1.6 -0.7 -0.3 0.4 -0.0
Coronary Artery Disease (CAD) 0.8 0.9 2.3 -1.4 -1.2 -0.3 -0.4 -0.2 1.2 0.7 1.0 1.5 0.8 0.2 -1.5 0.2
Crohns Disease (2012) 1.3 2.0 5.1 -2.1 -1.3 -2.2 -1.7 -0.5 2.1 0.6 0.4 1.7 1.5 -0.5 -1.1 0.8
Mean Putamen Volume 1.1 1.3 3.6 0.3 -0.2 -1.7 -0.9 1.0 0.9 1.4 1.6 0.7 1.5 0.5 -0.5 1.9
Fasting Glucose 0.7 0.9 2.1 0.6 -0.6 -1.2 -1.5 0.2 1.1 0.1 0.4 1.1 1.0 1.3 -1.1 0.7
HbA1C 2.1 2.4 6.7 0.6 -2.0 -1.1 -1.9 -0.1 1.9 1.8 2.0 0.1 1.1 2.6 0.8 1.4
HDL Cholesterol 0.7 1.1 3.0 0.2 -1.0 -0.5 -1.1 0.2 1.4 -0.6 0.7 -0.3 1.6 1.7 0.5 1.7
LDL Cholesterol 1.0 1.6 5.6 1.0 0.6 0.8 1.0 1.6 -1.2 -2.4 -1.3 -1.0 -1.1 0.5 1.7 -1.3
Lupus 0.6 0.9 3.9 -0.5 -0.2 0.9 0.6 -1.2 -1.2 0.7 0.0 0.7 -0.8 -0.9 -2.0 -1.2
Neuroticism (2016) 0.2 0.3 0.8 -0.1 -0.7 -0.7 0.3 0.3 -0.8 -0.6 0.4 0.4 -0.1 0.5 0.5 -0.9
Primary Biliary Cirrhosis 0.4 0.5 1.6 -0.2 0.2 1.0 0.5 0.2 -1.2 -1.3 -0.7 0.4 -0.8 -0.3 0.3 -0.8
Rheumatoid Arthritis 0.4 0.6 3.7 -0.3 0.3 0.6 0.5 0.9 0.5 -0.6 0.1 -0.8 -0.8 0.2 1.9 0.4
Schizophrenia (2014) 0.5 1.1 5.8 1.1 2.4 0.1 0.2 1.5 -0.7 0.5 -0.3 -1.4 -1.1 0.5 0.2 0.6
Triglycerides 1.3 2.1 6.4 1.2 1.7 2.2 2.5 2.2 -1.0 -0.1 -0.4 -1.5 -1.6 -0.2 0.6 -0.6
Type 2 Diabetes (T2D) (2012) 0.8 1.0 4.4 -0.7 0.1 0.8 0.8 0.2 -0.8 -0.9 -1.4 -0.0 0.4 -1.2 -2.1 -1.1
Ulcerative Colitis 1.0 1.5 4.2 -0.6 -1.9 0.4 -0.3 1.6 0.9 1.7 2.0 0.9 0.9 1.0 -1.1 0.9
Blood Eosinophil Count 0.4 3.0 8.9 -0.2 2.7 0.2 1.6 -0.8 -0.1 -3.0 -2.9 -0.7 -2.2 -1.4 0.3 -2.1
Blood Platelet Count 0.5 5.9 12.3 0.2 2.8 3.5 2.6 -1.1 -2.1 -2.1 -3.5 -1.5 -3.0 -2.3 -1.2 -3.1
Blood Red Count 0.2 1.8 7.1 0.5 -1.1 0.1 -0.6 1.5 -0.1 0.2 2.1 -0.4 1.8 2.0 -0.9 2.7
Blood White Count 0.3 2.3 6.7 -1.4 1.1 1.2 1.2 -2.6 0.4 -1.7 -2.3 -0.2 -1.0 -1.9 -1.1 -1.8
Heel T-Score 0.4 3.4 11.4 -2.8 0.9 0.8 0.7 -2.6 1.7 -3.4 -2.2 1.1 -1.7 -0.4 -1.1 -1.8
BMI 0.1 0.3 0.9 0.1 0.0 0.5 0.7 0.1 0.9 -0.1 -0.9 -0.9 0.1 -0.4 0.7 -0.4
Height 0.8 16.2 110.2 4.6 0.2 2.1 1.0 10.5 -3.2 3.6 4.0 -3.7 -0.1 2.6 2.6 2.8
Waist Hip Ratio (WHR) 0.3 1.3 9.5 0.9 0.9 0.8 0.3 3.1 -1.1 0.7 -1.1 -0.9 -0.2 -1.1 0.1 -0.1
Systolic Blood Pressure 1.1 5.6 16.4 -4.0 1.8 0.5 1.0 -3.4 -1.5 -0.5 -1.2 3.7 -1.6 -3.4 -2.5 -1.1
Smoking Status 0.4 0.9 2.6 -1.6 1.3 0.7 0.8 -0.4 -0.3 -1.2 -1.3 0.8 -1.1 -1.0 0.0 -0.5
Allergy or Eczema 1.4 3.6 8.8 1.4 -2.2 -3.0 -2.5 1.2 2.0 0.6 1.2 -0.5 2.9 1.9 0.8 2.1
Cardiovascular Disease 1.6 5.2 8.5 -2.4 2.9 1.2 2.5 -1.9 -2.7 -2.5 -2.4 1.2 -2.7 -2.5 -1.0 -2.3
Hypothyroidism (self reported) 0.1 0.3 1.2 0.1 -0.0 -1.1 -0.6 -0.2 -0.5 1.1 0.6 0.6 0.0 -0.5 -0.5 -0.1
Respiratory disease 0.9 1.9 11.6 1.2 1.9 -0.1 0.3 3.4 0.1 0.3 -0.4 -1.4 -0.6 -0.2 2.1 1.0
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.2 -0.8 -0.7 -1.5 -1.3 0.2 0.8 0.1 -0.0 0.9 1.3 -1.2 -0.4 1.5
Lung FEV1/FVC ratio 0.7 3.5 11.3 -3.0 0.2 1.8 1.7 -1.8 -1.4 -0.2 -0.4 2.7 -2.2 -3.4 0.3 -0.7
Lung FVC 0.2 0.9 3.9 -0.6 -0.5 0.1 -0.0 -0.5 -0.7 1.6 2.0 1.0 -0.0 0.9 -1.3 0.2
Neuroticism 0.5 1.3 8.3 0.3 0.6 -0.6 0.5 1.8 -2.9 0.2 0.5 0.4 -0.6 -0.7 1.7 -0.1
Chronotype (morning person) 0.5 1.1 3.8 -0.0 -1.4 0.1 0.1 1.8 0.4 -1.0 1.3 0.3 1.5 1.9 -0.2 0.5
Hair Pigment 0.0 0.4 3.0 0.1 -0.2 1.0 0.2 -0.6 0.6 -0.1 0.1 0.1 -0.5 0.3 0.2 1.7
Tanning 0.1 0.9 2.4 1.1 -1.1 -1.2 -1.6 0.1 1.1 1.4 1.0 -0.5 0.9 0.6 0.2 0.5
Hand grip strength (left) 0.2 0.5 1.5 0.9 -0.2 -0.1 -0.4 0.0 1.2 1.0 0.5 -1.0 -0.1 0.9 1.0 0.5
Number of treatments/medications taken 0.7 1.3 4.2 -0.1 1.9 1.1 1.4 0.9 -0.5 -2.0 -1.5 -0.5 -1.2 -0.2 -0.4 -0.8
Average weekly spirits intake 0.7 0.9 4.0 0.1 -0.5 -0.4 -1.3 0.7 2.0 0.7 0.6 -0.2 1.2 0.9 -0.5 1.0
Sensitivity / hurt feelings 0.4 0.6 2.8 1.2 0.3 0.0 0.6 0.5 -1.2 0.0 -0.5 -1.7 -0.1 -0.0 1.3 -0.4
Frequency of depressed mood in last 2 weeks 0.4 0.6 3.8 0.1 -0.3 -1.0 -0.4 1.0 -1.0 0.1 0.8 0.3 -0.1 -0.3 1.9 0.3
Hearing difficulty/problems: Yes 1.2 1.9 3.6 0.7 1.4 1.3 1.8 0.4 -1.9 -0.8 -1.7 -0.9 -1.7 -1.6 0.8 -1.6
Relative age of first facial hair 0.5 1.1 5.8 0.3 1.2 -0.7 0.0 2.4 -0.9 -1.2 0.7 0.6 -0.3 0.2 1.4 1.2
Other serious medical condition/disability diagnosed by doctor 1.3 1.7 6.8 0.1 1.3 -0.3 0.8 -1.0 -1.2 -1.6 -2.6 0.4 -0.7 -1.8 -0.5 -2.0
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.7 0.3 -1.3 -1.1 -1.0 0.0 1.0 0.3 -0.2 0.3 1.0 0.7 0.6 -0.4
Ever had hysterectomy (womb removed) 0.6 0.6 3.4 0.3 0.1 -1.8 -0.0 1.2 0.3 -1.0 -0.3 0.4 -0.1 0.3 1.4 -0.1
Systolic blood pressure, automated reading 1.2 3.6 11.4 -3.4 0.8 0.2 0.3 -3.1 -0.7 -0.4 -0.9 3.2 -0.9 -2.1 -2.8 -0.6
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.6 0.5 0.2 -1.3 -1.2 1.2 0.7 -0.2 -0.4 -0.9 0.3 0.6 -0.4 0.2
Angina 0.1 0.2 1.0 -0.3 0.1 0.3 0.3 -0.4 0.2 0.0 0.4 0.2 0.2 0.7 -1.0 -0.0
Medication for hormone replacement therapy 0.4 0.4 1.5 -0.9 -0.7 -0.4 -0.6 -0.3 0.4 -0.8 -0.3 0.2 0.7 0.6 -0.3 -1.2
Vitamin and mineral supplements 0.6 0.8 4.2 0.1 0.4 2.0 1.1 0.8 -1.1 -0.6 -0.4 -0.2 -0.9 -0.4 1.1 -0.6
Supplements: Zinc 0.5 0.5 1.0 0.1 0.9 0.8 1.0 -0.5 0.2 -0.9 -0.4 -1.0 -0.9 0.7 0.3 -0.7
Medication: Co-codamol 0.5 0.6 1.6 0.6 0.5 0.1 1.0 0.5 -0.7 -1.1 -1.1 0.2 -0.3 -0.3 -1.3 -1.2
Medication: Metformin 0.9 1.3 4.4 -0.1 -1.3 -1.7 -1.2 0.7 0.9 0.5 1.2 1.0 1.5 0.1 -0.2 2.1
Diabetes (father) 2.1 2.6 5.9 -1.3 -2.2 -1.7 -1.8 -1.0 1.8 1.2 1.5 2.4 1.8 0.4 1.0 1.8
Diabetes (mother) 0.4 0.5 2.7 -0.3 -0.3 0.9 0.7 -0.5 -1.6 0.2 0.5 1.0 0.0 -0.9 -0.5 -0.1
Severe depression (siblings) 0.9 1.0 6.1 1.4 0.1 -0.4 0.1 0.3 -1.4 -0.9 -1.0 -1.0 -0.4 0.3 2.5 -0.6
Pack years adult smoking proportion 0.7 1.1 3.0 1.3 1.3 0.3 0.7 -1.0 -0.2 -1.1 -1.7 -1.7 -0.5 0.3 -0.7 -1.3
Impedance of leg (right) 0.3 1.5 3.8 0.5 1.8 1.4 1.5 -0.3 -1.2 -1.5 -1.0 -0.8 -1.9 -0.6 0.2 -1.4
Leg fat-free mass (left) 0.5 2.8 15.6 2.3 -0.9 0.4 -0.1 4.0 -0.8 1.7 1.4 -1.7 0.9 1.4 1.2 1.3
Trunk fat percentage 0.3 1.1 4.2 0.6 0.7 -0.3 0.5 -0.7 -0.1 -1.8 -2.0 -1.2 -0.9 -0.2 0.7 -1.5
Hand grip strength (right) 0.2 0.4 1.1 0.8 -0.3 0.6 0.2 0.1 0.4 0.8 0.6 -1.0 -0.3 1.1 0.9 0.3
Townsend deprivation index at recruitment 0.9 1.2 3.9 0.6 0.7 -1.3 -0.6 1.5 0.9 -2.0 -1.1 -1.3 -0.1 0.8 1.5 -0.5
Current tobacco smoking 0.3 0.5 4.0 -2.0 -0.2 0.0 -0.4 -0.3 0.8 -0.9 0.0 0.6 0.5 0.6 -0.3 -0.0
Average weekly fortified wine intake 1.3 1.6 6.9 1.2 0.9 1.1 0.8 2.0 -0.3 -0.6 -1.0 -1.6 -1.0 -0.6 2.6 0.1
Maternal smoking around birth 0.2 0.4 1.2 0.2 0.3 -1.1 -0.7 0.9 0.5 -0.8 0.2 -0.3 0.5 0.8 0.4 0.1
Fed-up feelings 0.4 0.7 2.2 0.9 0.5 -1.5 -0.3 1.0 -1.3 -0.7 0.0 -0.3 -0.3 0.5 1.4 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 2.5 0.4 -0.2 -0.9 -0.4 0.6 0.1 0.0 0.9 -0.0 0.1 0.3 1.6 1.0
Relative age voice broke 0.3 0.4 1.3 1.0 0.2 -0.2 0.3 1.2 -0.6 -0.4 1.0 0.3 -0.0 0.3 0.7 0.7
Taking other prescription medications 0.6 0.9 3.8 0.8 2.0 -0.6 0.3 1.2 -0.8 -0.2 -1.2 -0.9 -0.9 -0.9 1.0 0.1
Age when periods started (menarche) 0.4 0.9 2.9 -1.0 1.3 -0.3 0.2 1.4 -1.2 -1.1 0.1 0.2 -0.8 -0.2 1.7 0.2
Bilateral oophorectomy (both ovaries removed) 0.7 0.9 2.8 -1.1 -0.7 -1.1 -0.3 -1.7 0.9 -1.3 -0.8 0.6 0.6 -0.1 0.9 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.8 6.1 -1.2 1.3 1.1 0.6 -0.9 0.1 -2.5 -2.4 0.0 -1.2 -0.8 -0.7 -1.8
Tinnitus: Yes, but not now, but have in the past 0.3 0.4 1.5 -0.2 -1.0 -0.2 -0.7 -1.2 -0.1 0.7 -0.0 0.6 0.4 0.1 -0.9 -0.0
Qualifications: CSEs or equivalent 0.6 0.8 2.9 0.2 0.4 -1.7 -1.2 -0.0 1.5 0.6 -0.0 -0.5 0.8 0.4 -1.3 0.0
Serious illness, injury or assault to yourself 0.9 1.1 5.1 1.7 0.6 -0.4 -0.5 1.2 0.4 0.2 -0.8 -2.3 0.2 0.4 1.4 1.0
High blood pressure 1.3 3.7 7.4 -2.5 2.7 0.6 1.9 -1.1 -2.2 -1.7 -1.8 1.5 -2.5 -2.7 -0.8 -1.5
Hayfever, allergic rhinitis or eczema 0.6 1.4 3.2 1.1 -1.8 -1.8 -1.5 0.6 1.2 -0.3 0.3 -0.5 1.6 1.5 0.0 0.9
Multivitamins +/- minerals 0.4 0.6 3.9 -0.3 -0.2 -1.0 -0.1 -1.0 0.1 0.0 0.5 0.6 0.1 0.8 -2.0 -0.3
Stomach or abdominal pain in last month 0.4 0.5 1.7 0.7 1.0 0.7 0.5 1.3 0.1 -0.3 0.3 -0.9 0.2 1.1 -0.4 0.7
Supplements: Glucosamine 1.4 1.8 4.9 2.2 -1.5 -1.3 -1.4 0.4 0.7 1.4 0.8 -1.4 1.5 1.3 1.0 1.7
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.9 -0.6 -0.8 -0.8 -0.4 0.7 0.3 0.3 0.8 1.2 1.1 0.6 -1.4 1.0
Medication: Atenolol 1.0 1.3 5.6 -1.1 -0.0 0.9 1.6 -0.9 -0.6 -2.4 -1.2 0.8 -0.6 -0.4 1.4 -1.1
Medication: Levothyroxine sodium 0.2 0.3 0.8 0.9 0.6 -0.8 -0.2 0.8 -0.3 0.3 -0.1 -0.9 -0.2 -0.0 0.7 0.5
Sitting height 0.7 5.0 19.4 3.7 -0.3 1.2 0.8 4.4 -0.8 2.1 2.4 -2.0 0.4 2.4 1.3 2.5
Chronic bronchitis/emphysema (father) 0.5 0.6 3.4 0.3 1.9 -0.1 0.3 -1.0 0.9 -0.3 -0.6 -0.4 -1.1 -0.0 -1.0 0.1
High blood pressure (mother) 2.6 3.7 7.5 -2.6 1.6 1.4 2.1 -1.7 -2.7 -0.7 -1.1 1.9 -2.5 -2.7 -0.8 -1.6
Body mass index (BMI) 0.2 0.8 3.1 -0.3 -0.3 -0.4 0.3 -1.4 -0.3 -1.4 -1.8 -0.2 -0.0 -0.5 0.0 -1.6
Impedance of leg (left) 0.2 1.1 3.1 0.3 1.8 1.1 1.2 -0.3 -1.1 -1.1 -0.8 -0.7 -1.7 -0.6 -0.3 -1.2
Leg predicted mass (left) 0.5 2.8 15.8 2.3 -0.8 0.5 -0.0 4.0 -0.8 1.8 1.4 -1.7 0.8 1.4 1.1 1.4
Trunk fat mass 0.2 1.0 3.0 1.3 0.4 0.3 0.9 0.8 -0.7 -1.1 -1.4 -1.7 -0.7 0.1 1.1 -1.0
Waist circumference 0.2 0.6 2.0 1.1 -0.2 0.3 0.4 1.4 -0.9 0.1 -0.8 -1.4 0.3 -0.3 0.4 -0.6
Number of incorrect matches in round 0.4 0.6 5.1 1.1 0.1 -0.0 -0.4 -0.0 -0.5 2.2 0.2 -0.2 0.5 -1.1 0.0 0.5
Past tobacco smoking 0.5 0.9 3.2 -0.0 -1.3 -1.0 -1.2 0.1 1.0 1.0 1.2 0.2 1.8 0.8 -0.8 0.4
Alcohol usually taken with meals 0.9 1.5 4.4 0.7 -2.1 -0.6 -1.3 -0.2 1.2 1.6 1.7 -0.0 1.4 1.0 0.5 1.6
Nervous feelings 0.8 1.4 6.2 0.1 1.6 0.5 0.7 -1.2 -2.5 -0.6 -1.1 0.9 -1.2 -1.8 0.6 -0.9
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 3.4 0.7 -0.9 -1.9 -0.9 0.7 0.4 -0.6 0.4 -0.5 0.7 1.0 1.8 0.8
Hearing difficulty/problems with background noise 0.4 0.6 3.2 -0.6 -0.4 -0.6 0.7 -0.1 -1.8 -0.4 0.2 1.1 -0.2 -0.4 -0.7 -0.9
Hair/balding pattern: Pattern 2 0.9 1.1 4.7 -2.2 -0.2 0.5 -0.1 -1.1 0.2 1.3 0.7 1.7 -0.3 -1.3 1.3 0.1
Had menopause 0.6 0.7 2.9 1.4 1.2 -0.0 0.3 0.1 0.1 0.6 -0.8 -1.7 -0.2 -0.2 1.2 0.6
Had other major operations 2.7 3.2 10.2 0.7 -2.4 -2.1 -1.4 1.0 1.1 0.9 3.2 0.3 2.4 2.7 0.6 1.6
Forced vital capacity (FVC) 0.8 3.2 11.1 2.4 -0.8 2.0 0.6 3.3 -1.0 2.2 2.6 -1.4 0.4 1.6 0.6 1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 4.6 -0.9 1.7 1.6 1.1 -1.2 0.5 -1.8 -2.1 -0.4 -1.6 -0.6 -0.5 -2.0
Ever unenthusiastic/disinterested for a whole week 1.1 1.3 7.2 1.3 -0.5 0.8 0.3 0.3 -2.7 -0.4 -1.2 -0.4 -0.5 -0.4 -1.4 -1.8
Qualifications: None of the above 0.4 0.8 2.3 1.0 1.2 1.5 1.1 0.2 -0.9 -0.7 -1.3 -1.0 -0.9 -0.3 0.1 -0.5
Financial difficulties in last 2 years 0.4 0.5 2.2 -0.2 0.2 -0.7 0.0 1.3 0.2 -1.5 -0.4 -0.2 -0.1 0.4 0.6 -0.9
Mouth/teeth dental problems 0.1 0.2 0.6 -0.0 0.8 0.6 0.6 0.1 0.5 0.4 0.2 0.1 -0.7 -0.4 0.2 0.2
Heart attack 1.0 1.3 4.9 -1.2 1.2 2.2 1.6 -0.2 -1.2 -0.1 -0.1 0.9 -1.1 -0.5 -1.5 -0.5
Allergy 0.8 1.8 4.3 -2.0 0.7 1.9 1.4 -2.1 -1.2 0.3 -0.2 1.3 -1.6 -1.7 -0.4 -0.8
Pain all over the body in last month 0.1 0.1 0.4 0.2 -0.2 -0.5 0.1 -0.7 0.2 -0.1 -0.0 0.2 -0.3 0.3 -0.3 0.0
Diabetes (self-reported) 0.8 1.2 3.8 -0.1 -0.4 -1.7 -1.2 1.2 1.2 0.9 1.3 0.5 1.3 0.2 -0.3 1.9
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 3.6 -1.0 -1.9 -1.5 -1.4 -0.9 1.8 -0.1 0.6 1.5 1.7 0.8 -1.9 0.5
Medication: Ramipril 0.5 0.6 1.7 -0.8 0.9 0.3 1.1 0.3 -1.3 -1.1 -0.5 0.1 -0.6 -0.9 -0.2 -0.9
Medication: Simvastatin 1.0 1.5 5.3 -0.2 1.2 1.8 2.3 -0.9 -0.7 -1.1 -1.2 0.8 -1.7 -1.2 -0.1 -0.9
Fluid intelligence score 0.3 0.6 1.6 0.8 0.8 0.8 0.8 -1.1 -0.1 0.7 -0.1 -0.5 -1.0 -0.6 1.3 -0.1
Illnesses of siblings 0.6 0.8 3.1 1.3 -0.9 1.0 -0.0 0.2 0.6 0.9 1.0 -0.5 0.3 1.8 0.2 1.0
Neuroticism score 0.5 1.0 6.6 -0.1 1.1 -0.8 0.3 0.3 -2.6 -0.7 -0.1 0.4 -0.9 -0.4 1.8 -0.6
Weight 0.3 1.4 6.4 1.9 -0.2 0.7 0.6 2.5 -1.1 0.3 -0.1 -1.9 -0.0 0.8 1.2 -0.1
Impedance of arm (right) 0.2 0.8 3.6 0.2 1.8 -0.2 -0.3 -0.3 1.9 -1.0 -0.9 -0.5 -1.2 0.0 0.6 -0.0
Arm fat percentage (right) 0.4 1.6 6.3 -0.4 0.7 -0.6 0.3 -1.9 0.7 -2.1 -2.5 -0.5 -0.8 -0.5 0.5 -1.8
Trunk fat-free mass 1.0 5.7 31.4 3.1 -0.7 1.6 0.8 5.6 -1.9 2.4 2.1 -2.5 0.5 1.8 1.6 1.5
Hip circumference 0.1 0.3 1.2 0.5 -0.5 0.2 0.6 0.1 -1.1 -0.4 -0.0 -0.4 -0.2 0.1 0.4 -0.8
Time employed in main current job 1.6 1.9 6.5 2.3 0.6 -1.0 -0.7 1.1 1.4 -0.5 -0.7 -2.5 0.4 1.7 1.8 0.4
Alcohol intake versus 10 years previously 0.5 0.7 1.9 0.1 1.4 0.3 0.2 0.3 -0.2 -0.5 -0.9 -0.9 -1.0 -1.0 1.2 -1.0
Father’s age at death 2.3 3.1 9.1 0.9 -2.0 -0.9 -1.6 1.3 1.2 2.5 3.0 0.2 2.4 1.2 0.3 2.5
Worrier / anxious feelings 0.6 1.2 2.7 -0.1 -1.6 -1.1 -0.7 0.9 -1.3 0.6 1.7 1.6 1.2 0.6 0.5 0.9
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 2.8 1.2 0.8 -1.3 -1.1 1.7 0.3 1.2 -0.1 -1.0 0.7 0.2 0.3 1.6
Falls in the last year 0.8 1.1 3.3 0.4 -0.6 -1.5 -0.7 1.0 1.2 -1.8 -0.6 -1.1 1.2 1.3 0.5 -0.2
Hair/balding pattern: Pattern 3 0.4 0.5 3.9 -0.1 -0.1 0.0 0.4 0.7 0.3 -2.0 0.3 -0.1 -0.1 1.4 0.5 0.1
Number of live births 0.5 0.8 3.0 0.7 0.3 -0.5 -0.3 1.2 0.3 1.7 0.8 0.0 0.1 -0.5 1.4 1.3
Forced expiratory volume in 1-second (FEV1) 0.5 1.7 6.4 1.0 -0.2 2.5 1.4 1.9 -1.6 1.6 1.7 -0.2 -0.7 -0.0 0.2 0.6
Pulse rate 0.2 0.4 1.2 -0.8 -1.1 -0.0 -0.5 0.1 -0.1 1.1 0.9 0.7 0.3 -0.0 -1.0 0.2
Happiness 0.4 0.5 3.9 -0.0 0.4 0.1 0.1 0.1 -0.3 2.0 0.4 0.3 -0.4 -1.4 -0.6 0.0
Noisy workplace 0.5 0.6 4.4 -0.8 -0.4 0.1 0.2 -0.4 0.3 0.1 -0.3 0.6 0.2 -0.0 -2.1 -1.2
Qualifications: A levels/AS levels or equivalent 1.7 3.8 8.4 0.3 -2.0 -2.4 -2.4 0.2 2.4 0.9 2.4 0.8 2.2 2.9 -0.8 2.7
Serious illness, injury or assault of a close relative in last 2 years 3.3 3.8 13.1 -0.6 1.9 1.8 2.6 -1.3 -2.0 -1.2 -2.6 0.5 -1.8 -3.6 -0.6 -2.1
Mouth/teeth dental problems: Dentures 0.2 0.4 1.5 -0.3 -0.8 0.1 -0.2 0.2 -0.9 0.1 0.4 0.8 0.6 0.4 -1.2 -0.6
Asthma 1.7 3.3 13.0 1.7 3.6 0.5 1.5 2.2 -1.7 -0.2 -1.9 -1.8 -2.1 -1.7 1.5 -0.5
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 5.1 1.0 0.5 -0.4 -0.9 2.3 0.4 -0.9 0.1 -1.6 0.5 0.7 0.6 0.6
Medication: Cholesterol lowering 1.6 2.6 5.3 -2.0 0.4 2.3 2.2 -0.6 -1.7 -1.3 -1.3 1.5 -1.6 -2.2 -0.6 -1.4
Depression (self-reported) 0.5 0.6 1.7 0.0 1.1 -0.8 0.4 1.3 -1.3 -0.6 -0.7 -0.2 -0.6 -1.0 0.6 -0.5
Medication: Lansoprazole 0.7 0.8 4.4 -1.0 1.0 0.1 0.1 -2.1 0.7 0.4 -0.4 0.6 0.1 -0.7 -1.6 -0.1
Prospective memory result 1.8 2.2 12.0 -1.4 -1.5 -0.6 -0.2 -0.3 -0.6 1.1 1.2 2.8 0.6 -0.3 -3.5 -0.3
Lung cancer (father) 0.8 1.0 4.5 1.5 0.8 0.5 0.7 1.1 -0.3 -0.9 -1.0 -2.1 -0.5 0.6 0.6 -0.7
Illnesses of mother 2.4 2.9 6.9 2.6 -1.3 -0.6 -1.5 1.9 2.4 1.0 0.9 -1.9 1.5 2.5 1.4 1.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.2 6.6 0.1 0.9 2.6 1.9 2.1 -2.1 1.8 1.7 0.2 -1.5 -0.6 -0.5 0.4
Pulse wave Arterial Stiffness index 0.3 0.4 1.2 -1.0 -0.2 -1.0 -0.7 -0.8 -0.1 -0.3 -0.1 0.1 0.1 -0.3 1.1 0.2
Impedance of arm (left) 0.1 0.7 2.8 0.7 1.3 -0.5 -0.5 -0.1 1.7 -0.8 -0.3 -0.8 -1.0 0.5 0.9 0.1
Arm fat mass (right) 0.1 0.5 2.2 0.4 0.3 -0.1 0.4 -0.0 -0.0 -0.9 -1.5 -1.1 -0.5 -0.1 0.9 -1.1
Trunk predicted mass 1.0 5.7 31.6 3.1 -0.6 1.7 0.9 5.6 -1.9 2.4 2.0 -2.6 0.4 1.7 1.7 1.5
Standing height 1.3 12.7 69.4 4.7 -0.3 2.2 0.6 8.3 -1.6 3.7 3.8 -3.4 0.1 2.8 2.8 3.2
Length of working week for main job 0.4 0.5 1.3 -1.0 0.2 -0.8 -0.1 -0.6 1.1 -1.1 -0.2 0.2 0.1 0.6 -1.1 -0.4
Exposure to tobacco smoke at home 4.7 5.2 11.8 -1.2 3.4 0.6 1.4 -1.4 -2.0 -3.3 -3.4 -0.6 -2.9 -2.1 0.2 -3.2
Breastfed as a baby 1.2 1.5 4.6 0.7 -1.6 0.2 -0.6 2.1 0.2 2.1 1.7 0.8 1.2 -0.2 -0.2 1.6
Tense / ‘highly strung’ 2.2 3.6 9.8 0.3 2.6 1.3 2.1 1.0 -3.1 -1.2 -1.2 -0.9 -2.4 -2.1 2.7 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 4.4 0.2 1.2 0.2 0.8 -0.7 -2.1 -0.1 -0.4 0.5 -1.0 -0.7 -0.2 -1.3
Hair/balding pattern: Pattern 4 1.2 2.9 10.5 -0.8 0.3 1.4 1.6 -2.0 -2.1 -3.2 -1.6 0.0 -1.1 0.4 -2.0 -2.4
Birth weight of first child 1.8 3.3 16.0 2.2 -1.0 0.0 -0.6 4.0 1.4 1.5 1.6 -1.2 1.7 2.4 0.1 1.8
Peak expiratory flow (PEF) 1.2 2.7 12.2 0.0 0.6 3.5 2.5 -1.1 -2.5 -0.7 -0.9 0.0 -1.8 -1.5 0.1 -1.3
Pulse wave reflection index 0.3 0.4 2.8 -0.7 0.1 -0.6 -0.5 -1.7 -0.5 -0.1 -0.2 -0.0 0.3 -0.4 0.6 0.2
Ever highly irritable/argumentative for 2 days 0.6 0.7 3.3 0.6 -1.3 -0.3 -0.7 -0.0 0.2 0.8 -0.1 -0.1 1.5 0.3 -1.8 -0.7
Loud music exposure frequency 0.8 0.9 2.9 -0.4 1.7 0.0 0.6 0.2 -0.3 -0.3 -1.1 -1.3 -1.7 -0.5 0.8 -1.3
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 4.2 -1.2 -0.9 0.3 -0.8 0.0 2.1 0.1 1.2 0.6 0.7 1.3 -0.3 1.4
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 2.7 0.2 0.7 0.5 0.5 -0.0 -0.3 -1.3 -1.6 -1.1 -0.7 -0.6 0.7 -0.8
Blood clot in the leg (DVT) 2.1 2.8 8.7 0.1 2.1 2.7 3.0 0.9 -1.8 -0.7 -0.3 0.3 -2.3 -0.0 -1.2 -2.0
Medication: Paracetamol 0.5 0.8 3.7 1.5 0.9 -0.3 -0.7 1.0 0.2 -0.0 -0.6 -1.9 0.3 1.1 -0.7 -0.2
Headache pain in last month 0.7 1.3 4.9 1.1 2.1 -0.1 0.3 1.1 0.7 -0.6 -0.4 -2.2 -0.5 0.8 1.6 0.3
Medication for cholesterol, blood pressure or diabetes 2.0 3.3 8.6 1.0 -1.5 -2.3 -2.6 0.3 2.6 1.1 1.9 -0.8 1.9 2.9 1.0 1.4
Glaucoma (self-reported) 0.4 0.5 2.1 -0.5 -1.1 -0.9 -0.9 -0.0 0.4 -0.4 0.4 0.5 1.5 0.1 -0.1 0.6
Gout (self-reported) 0.3 0.4 2.0 -0.6 0.7 -0.4 0.3 -0.1 -0.2 -1.4 -0.1 0.3 -0.1 0.6 -1.2 -0.6
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.6 0.1 0.5 -0.9 0.1 0.3 -1.3 -0.1 -0.3 0.4 -0.4 -0.8 -0.3 -0.8
Medication: Amlodipine 2.4 3.4 9.8 -0.2 2.1 2.0 2.7 0.1 -2.6 -0.1 -1.5 0.2 -2.3 -3.1 -1.1 -1.8
Medication: Ventolin 100micrograms inhaler 0.7 0.9 3.6 1.1 1.9 0.2 -0.1 0.7 -0.2 -0.1 -1.3 -1.1 -1.4 -0.4 0.7 -0.2
Birth weight 1.0 2.2 13.2 -0.5 -1.6 0.6 0.6 3.6 -0.6 1.8 1.6 1.5 0.8 0.4 -1.7 0.4
Chronic bronchitis/emphysema (mother) 0.6 0.7 2.0 0.2 0.3 -0.9 -0.3 -1.1 0.7 -1.3 -1.0 -1.0 0.2 0.3 1.4 -0.6
High blood pressure (siblings) 2.1 3.0 6.2 -1.9 2.5 -1.2 0.5 -1.2 -1.4 -2.1 -2.4 0.8 -1.8 -2.5 -1.0 -1.7
Forced vital capacity (FVC), Best measure 0.6 2.4 9.0 1.1 0.3 2.1 1.2 3.0 -1.4 2.0 2.5 -0.5 -0.4 1.0 -0.5 1.1
Body fat percentage 0.4 1.7 6.2 0.3 0.7 -0.1 0.9 -1.4 -0.4 -2.2 -2.5 -1.0 -1.1 -0.7 0.6 -2.0
Leg fat percentage (right) 0.9 3.1 8.8 -0.2 1.0 0.8 2.0 -2.1 -1.6 -2.5 -2.7 -0.6 -1.9 -1.1 0.2 -3.0
Arm fat-free mass (right) 0.9 4.8 24.7 3.0 -0.9 1.2 0.6 5.0 -2.3 2.7 1.9 -2.1 0.6 1.1 1.4 1.4
Exposure to tobacco smoke outside home 0.5 0.6 2.1 0.4 1.3 1.5 1.0 0.1 -0.7 0.2 -0.3 -1.3 -0.5 -0.2 0.5 -0.3
Comparative body size at age 10 0.9 2.6 12.2 -2.7 -1.5 -0.9 0.0 -2.4 0.1 -0.3 0.1 3.5 0.4 -1.6 -1.6 -0.5
Number of full brothers 0.3 0.4 2.3 -0.3 0.1 -0.7 -0.3 1.5 -1.1 -0.3 -0.3 0.4 0.1 -0.2 0.3 0.1
Worry too long after embarrassment 0.2 0.3 1.5 0.1 0.9 -0.1 0.5 0.2 -1.2 -0.3 -0.3 0.1 -0.5 -0.3 1.0 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 4.0 1.1 0.4 -0.1 0.1 -0.4 -2.0 -0.5 -0.4 -0.4 -0.2 0.8 0.6 -1.0
Wheeze or whistling in the chest in last year 0.7 1.2 5.8 1.0 2.4 -0.6 0.4 0.6 -0.2 -0.3 -1.6 -1.5 -1.1 -0.7 0.9 -0.4
Number of children fathered 1.0 1.1 3.6 -0.9 1.8 0.1 1.2 0.3 -1.1 -1.5 -0.8 0.4 -1.9 -0.8 0.8 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 4.0 -0.1 0.4 -0.9 -1.3 0.8 2.0 0.5 0.8 0.4 0.5 1.3 1.0 1.8
Age at first live birth 0.6 1.1 4.4 -2.0 -0.9 -0.0 -0.0 0.3 -0.4 0.3 1.4 2.1 0.2 -0.3 -1.1 0.8
Pulse wave peak to peak time 0.4 0.4 1.9 1.0 0.3 1.1 0.7 1.4 -0.1 0.5 0.2 -0.1 -0.2 0.2 -0.8 -0.0
Health satisfaction 0.1 0.2 0.5 0.2 0.6 -0.5 -0.5 0.5 -0.7 -0.1 -0.5 0.2 -0.2 -0.4 0.2 0.1
Shortness of breath walking on level ground 0.7 0.8 3.1 0.8 0.3 -1.6 -0.4 1.1 0.7 0.3 -0.6 -1.0 0.1 -0.5 1.8 0.1
Qualifications: College or University degree 0.1 0.5 2.6 -0.8 -0.2 -0.7 -0.1 -0.4 -0.2 -1.6 -0.5 0.8 -0.2 0.2 0.8 0.4
Eye problems/disorders: None of the above 0.8 0.9 3.2 -0.9 -0.1 0.8 0.3 -1.8 -1.2 0.7 0.2 1.4 -0.1 -1.2 -1.2 -0.7
Mouth/teeth dental problems: Loose teeth 0.4 0.5 3.8 -0.5 0.3 -0.5 -0.2 0.4 -0.2 -0.3 -0.3 0.1 -0.6 -0.9 1.9 0.6
Emphysema/chronic bronchitis 1.3 1.5 4.8 1.8 -0.3 -1.3 -1.2 0.9 0.4 -1.2 -1.2 -2.2 1.4 1.0 0.9 -0.6
Medication for pain relief, constipation, heartburn 0.3 0.6 2.1 -0.6 -1.1 -0.1 0.0 -1.5 -0.8 0.5 0.7 1.4 0.0 -0.5 0.6 0.1
Neck or shoulder pain in last month 1.2 1.7 5.3 0.1 0.8 -2.3 -1.6 0.9 1.8 -1.3 -0.1 -1.3 1.4 1.7 -0.0 1.3
Medication: Blood pressure 1.0 1.7 4.8 -0.7 1.1 1.6 1.9 0.6 -2.1 -0.9 -0.9 0.7 -1.3 -2.2 -0.8 -0.8
Angina (self-reported) 0.1 0.2 0.6 -0.4 0.2 0.2 0.3 -0.5 0.4 -0.2 0.2 0.2 0.1 0.8 -0.7 -0.1
Migraine (self-reported) 0.5 0.6 1.6 -0.4 1.0 0.8 0.9 0.1 0.3 -0.7 -0.9 -0.4 -0.7 -1.3 1.1 -0.1
Medication: Ibuprofen 0.5 0.6 3.2 0.8 1.0 0.2 -0.1 1.8 0.0 -0.9 0.3 -1.2 -0.1 0.8 0.4 0.2
Medication: Allopurinol 0.7 1.0 3.3 -0.5 0.5 0.5 0.8 -1.4 -0.4 -1.8 -1.0 0.5 -0.7 0.3 -1.4 -1.4
Medication: Omeprazole 1.3 1.5 7.1 1.6 -0.3 -0.8 -0.3 1.7 1.0 -1.4 -0.7 -0.7 0.0 1.4 2.7 0.8
Medication: Seretide 50 evohaler 0.8 1.0 3.5 0.6 0.9 -1.4 -0.4 -0.6 0.5 -0.3 -1.4 -1.9 0.2 -0.4 1.7 0.4
Mean time to correctly identify matches 0.3 0.6 2.4 -0.9 0.4 0.9 0.9 -0.6 -0.6 0.2 -0.1 0.9 -0.5 -1.0 -1.6 -0.5
Heart disease (mother) 2.8 3.4 8.2 -2.1 -0.0 0.1 0.7 -2.9 -2.6 -1.4 -0.9 2.4 -0.3 -1.9 -2.4 -2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.8 2.1 8.6 2.9 1.3 -0.8 -0.8 0.2 0.9 0.7 -1.8 -2.6 -0.4 -1.2 1.8 0.7
Whole body fat mass 0.3 1.1 3.5 0.9 0.4 0.4 1.0 0.2 -0.8 -1.4 -1.9 -1.6 -0.8 -0.3 0.9 -1.4
Leg fat mass (right) 0.3 1.3 3.2 0.9 0.3 0.8 1.4 0.1 -1.4 -1.4 -1.7 -1.4 -1.0 -0.3 0.8 -1.8
Arm predicted mass (right) 0.9 4.6 22.6 3.1 -0.8 1.2 0.6 4.8 -2.1 2.3 1.8 -2.3 0.6 1.3 1.8 1.4
Pulse rate, automated reading 0.3 1.0 5.1 -1.5 0.2 0.7 0.3 -2.2 -1.0 -0.4 -0.0 1.1 -0.8 -0.5 -1.2 -0.5
Alcohol intake frequency. 0.4 0.9 3.3 -0.1 1.3 0.7 1.1 -0.1 -1.8 -0.7 -0.4 -0.3 -1.3 -0.6 0.3 -1.6
Comparative height size at age 10 1.3 7.1 35.0 2.7 -1.3 1.5 0.6 5.9 -0.0 3.9 4.1 -1.3 0.9 1.9 0.6 2.8
Number of full sisters 0.7 0.9 5.3 1.6 -0.3 -0.7 -0.6 2.3 -0.3 0.7 0.7 -0.2 0.6 0.8 -0.3 0.7
Suffer from ‘nerves’ 0.9 1.4 2.6 -0.4 1.6 -0.2 0.8 -1.6 -1.5 -0.8 -0.7 1.2 -1.6 -1.3 -0.7 -1.6
Overall health rating 0.6 1.2 2.5 1.3 1.4 -1.0 -0.1 1.1 0.6 -1.5 -1.4 -1.5 -0.2 0.1 1.6 0.3
Chest pain or discomfort 0.4 0.6 2.1 1.0 1.2 0.0 0.9 0.3 -0.7 -1.4 -0.9 -0.9 -0.3 0.2 0.1 -0.6
Had major operations 1.4 1.7 5.8 -0.0 0.8 2.2 2.4 0.2 -1.7 -0.4 -0.3 -0.2 -1.2 -0.2 -1.4 -1.9
Age at last live birth 0.9 1.3 5.7 -1.8 -0.4 0.7 0.1 0.1 -0.5 1.3 1.9 2.4 -0.2 0.0 -0.8 0.8
Family relationship satisfaction 0.6 0.8 2.1 1.1 -0.5 -0.9 -1.5 1.2 0.8 0.8 -0.1 -0.8 1.2 0.4 -0.2 0.1
Leg pain on walking 0.3 0.4 1.4 -0.1 -0.3 -0.1 0.2 -0.6 0.1 -1.2 -0.6 0.4 0.0 1.0 -1.0 -0.9
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 1.6 -0.3 -0.5 -1.1 0.0 0.1 0.2 -0.2 1.3 0.2 -0.0 1.0 -0.2 -0.4
Commuting to job workplace: Car/motor vehicle 0.7 0.8 5.1 1.2 0.9 -0.0 0.1 0.0 1.4 0.1 -0.3 -2.2 -0.2 0.7 0.5 0.8
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 2.8 0.2 0.3 -1.0 -0.7 -0.1 -0.1 -0.3 0.6 -0.8 -0.7 1.7 0.3 -0.3
Medication: Aspirin 0.5 0.7 1.8 1.0 1.1 1.3 1.3 0.4 0.0 0.3 -0.9 -1.1 -0.9 -0.4 -0.6 -0.1
Supplements: Vitamin C 0.3 0.4 1.2 0.6 -0.1 -0.8 -0.8 -1.1 0.1 0.3 -0.7 -0.5 0.3 -0.8 0.1 -0.3
Knee pain experienced in last month 1.5 2.4 5.0 1.7 2.1 1.0 1.4 0.7 -2.2 -1.4 -2.0 -1.8 -1.3 -0.9 1.2 -1.4
Hypertension (Self-reported) 1.3 3.7 8.9 -2.2 3.0 0.6 2.1 -1.1 -2.3 -1.9 -1.8 1.1 -2.6 -2.3 -1.0 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.4 1.7 5.3 0.6 -0.2 -1.2 -0.9 1.6 1.6 -1.0 0.6 -0.5 1.1 2.3 1.6 1.9
Illnesses of father: Heart disease 2.5 3.5 8.1 -2.1 1.8 1.2 1.7 -2.3 -2.8 -1.7 -1.3 1.5 -2.1 -2.1 -0.9 -2.0
Illnesses of siblings: Diabetes 1.9 2.3 5.7 1.5 -1.4 -1.3 -1.6 2.1 0.9 0.7 0.4 -1.2 2.4 -0.2 1.8 2.2
Smoking status: Previous 0.8 1.3 4.5 0.6 1.8 0.8 1.1 -0.4 -1.6 -0.6 -1.3 -0.2 -2.1 -1.0 0.8 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.0 8.8 1.1 -1.0 -0.4 -0.6 3.0 0.6 1.4 2.1 -0.5 0.6 2.0 0.8 1.8
Whole body fat-free mass 0.8 4.6 25.3 2.9 -0.7 1.2 0.5 5.0 -1.6 2.3 1.9 -2.3 0.6 1.6 1.5 1.5
Leg fat-free mass (right) 0.5 2.9 15.0 2.2 -1.0 0.2 -0.4 3.9 -0.5 2.1 1.6 -1.6 1.1 1.4 0.9 1.6
Arm fat percentage (left) 0.4 1.6 6.2 -0.0 0.6 -0.5 0.4 -1.7 0.5 -2.1 -2.5 -0.9 -0.8 -0.5 0.8 -1.9
Average weekly red wine intake 3.2 4.7 8.9 -2.0 -2.9 -1.5 -2.1 -1.2 2.0 1.6 3.0 2.8 2.4 1.5 -2.3 2.0
Handedness (chirality/laterality): Left-handed 1.3 1.5 4.2 0.2 -1.2 -0.6 -1.5 0.7 2.0 2.0 1.6 -0.2 1.5 0.8 0.0 1.3
Mood swings 0.3 0.6 2.6 0.6 0.7 -0.6 -0.2 0.4 -1.0 0.6 0.7 0.5 -0.7 0.1 1.6 0.7
Loneliness, isolation 0.9 1.3 3.6 0.1 1.3 -0.9 0.4 1.4 -1.9 -1.6 -0.7 -0.2 -1.2 -0.4 1.6 -1.1
Long-standing illness, disability or infirmity 1.1 1.7 3.8 1.9 1.3 -0.8 -0.3 1.5 0.0 -1.8 -1.6 -1.9 0.3 1.8 -0.8 -0.3
Ever had bowel cancer screening 0.2 0.3 0.6 -0.2 0.8 -0.2 -0.0 -0.5 -0.7 -0.1 -0.7 0.1 -0.5 -0.8 0.7 0.5
Diabetes diagnosed by doctor 0.9 1.5 4.5 0.5 -0.8 -1.8 -1.4 1.7 1.0 0.7 1.2 -0.3 1.7 0.4 0.0 2.1
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.8 0.9 -0.9 0.1 0.3 0.6 -0.3 0.4 0.1 -0.5 0.4 0.0 0.4 -0.4
Friendships satisfaction 0.9 1.1 6.0 1.7 0.4 0.1 -0.8 1.0 0.1 2.4 0.2 -1.2 0.5 -0.4 -1.1 0.6
Qualifications: nursing, teaching 0.2 0.3 0.6 0.7 0.4 0.7 0.7 -0.4 0.4 0.2 0.4 -0.8 -0.4 0.6 -0.3 0.7
Commuting to job workplace: Walk 0.8 0.9 3.1 1.5 0.2 0.2 0.0 0.5 -1.2 -0.9 -1.2 -1.2 -0.3 -0.0 1.8 -0.7
Eye problems/disorders: Cataract 0.7 0.8 2.0 0.5 1.4 -0.3 0.4 0.1 0.7 -1.0 -1.2 -1.4 -1.3 0.6 0.8 0.0
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.7 -0.2 -0.1 0.1 0.1 0.6 -0.2 -0.5 0.3 -0.0 0.1 -0.3 0.7 0.8
Medication for cholesterol 0.4 0.6 2.5 0.6 -1.6 0.3 -0.1 0.6 -0.3 1.4 0.9 -0.2 0.8 -0.9 0.8 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.6 -0.0 0.9 -0.1 0.2 1.3 0.7 -0.6 0.1 -0.3 -0.4 1.2 -0.5 -0.3
Back pain experienced in last month 0.1 0.1 0.5 -0.6 0.3 0.0 0.6 -0.5 0.0 0.1 0.5 0.3 0.0 -0.1 -0.7 -0.0
Mineral and other dietary supplements 0.5 0.7 2.8 -1.4 0.6 1.7 0.7 1.5 -0.2 -0.4 0.5 0.5 -0.8 -0.1 -0.3 -0.3
Breast cancer (self-reported) 2.2 2.6 14.1 2.3 1.2 1.5 0.5 0.8 -1.5 0.8 -1.2 -3.8 -1.1 -0.8 1.8 -0.7
Asthma (self-reported) 1.9 3.9 14.4 1.6 3.8 0.4 1.4 2.4 -1.8 -0.5 -2.4 -1.9 -2.3 -1.9 1.6 -0.6
Osteoporosis (self-reported) 2.8 3.4 16.1 0.5 -0.8 -1.6 -1.5 4.0 1.4 2.3 2.5 0.2 1.3 1.1 1.0 2.3
Osteoarthritis (self-reported) 1.4 1.9 4.2 1.2 1.5 1.6 1.7 -0.6 -0.9 -1.6 -1.8 -1.5 -1.3 0.2 -0.3 -2.1
Medication: Aspirin 0.6 0.8 2.2 0.2 1.4 1.3 1.5 0.2 -0.2 0.0 -1.2 -0.3 -1.3 -1.2 -0.5 -0.3
Medication: Gliclazide 1.0 1.1 2.2 -1.1 -1.4 -0.8 -1.0 0.8 0.7 0.6 1.2 1.5 1.4 0.7 -0.7 1.4
Illnesses of father: None of the above (group 1) 0.5 0.7 2.1 1.1 -0.9 0.7 0.3 1.4 -1.1 0.4 -0.1 -1.4 0.4 0.1 -0.2 -0.6
Smoking status: Current 0.3 0.5 3.5 -1.9 -0.3 0.2 -0.3 0.1 0.9 -0.9 -0.1 0.3 0.6 0.4 -0.3 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.5 5.7 -0.9 0.6 1.5 1.6 0.1 -2.4 -0.0 -0.1 1.2 -1.2 -1.6 -1.1 -1.1
Whole body water mass 0.8 4.8 25.7 3.0 -0.8 1.2 0.5 5.1 -1.6 2.2 1.8 -2.4 0.7 1.8 1.6 1.5
Leg predicted mass (right) 0.5 2.9 15.2 2.2 -1.0 0.2 -0.3 3.9 -0.6 2.2 1.6 -1.6 1.1 1.4 0.9 1.6
Arm fat mass (left) 0.2 0.7 2.1 0.8 0.3 0.1 0.6 0.2 -0.1 -0.9 -1.4 -1.4 -0.5 0.2 1.1 -1.2
Number of self-reported non-cancer illnesses 0.6 1.1 4.5 -0.2 2.1 -0.5 1.2 0.7 -0.3 -2.0 -1.2 -0.4 -1.0 0.3 -0.7 -0.4
Average weekly champagne plus white wine intake 0.5 0.7 4.7 0.7 -1.1 -0.2 -0.2 -0.1 -0.4 -1.1 0.0 -0.1 0.7 0.7 2.2 0.2
Miserableness 0.8 1.4 8.3 0.4 1.7 -0.4 1.2 -0.3 -2.9 -1.3 -0.4 -0.5 -1.0 -0.2 0.7 -1.1
Guilty feelings 1.1 1.7 6.0 -0.8 -1.5 -1.6 -0.6 1.1 -0.3 0.4 1.9 1.3 1.0 0.3 2.5 1.5
Wears glasses or contact lenses 0.5 0.6 1.5 0.5 -0.0 0.9 1.1 0.7 -1.2 0.6 1.2 0.1 -0.0 0.4 -0.9 -0.6
Ever taken oral contraceptive pill 0.3 0.3 0.9 -0.8 0.4 -0.2 -0.1 -0.8 -0.2 -0.7 -0.5 0.8 -0.1 -0.6 -0.9 -0.6
Hearing aid user 1.3 1.4 2.6 1.6 1.4 1.4 1.4 0.4 -1.6 0.5 -0.5 -1.6 -1.1 -0.6 1.4 -0.8
Mother’s age at death 1.3 1.6 4.3 -0.3 -2.1 -0.9 -1.5 -0.9 1.2 1.5 1.6 0.7 1.4 0.8 -0.5 1.9
Financial situation satisfaction 0.4 0.5 1.5 0.3 -0.3 -0.8 -1.0 0.3 0.2 1.2 0.9 0.7 0.6 -0.0 -1.0 0.5
Tinnitus: Yes, now most or all of the time 0.3 0.4 2.1 -0.3 0.3 -0.2 0.3 -0.2 0.0 -1.5 0.3 1.1 -0.4 0.8 -0.2 0.4
Commuting to job workplace: Public transport 1.8 2.1 7.6 -1.6 -2.0 -0.4 -1.1 -0.2 1.0 -0.6 1.6 2.8 1.8 1.8 -1.4 0.3
Eye problems/disorders: Glaucoma 0.6 0.7 2.5 -1.6 -0.1 -0.7 0.1 -0.3 -0.3 -1.6 -0.8 0.7 0.2 -0.6 -0.9 -1.1
Medication: Blood pressure 0.6 1.1 5.9 -0.2 2.4 0.2 1.2 -0.8 -0.7 -0.9 -1.0 -0.2 -1.7 -0.1 -0.9 -0.7
Pain type(s) experienced in last month: Hip pain 1.2 1.5 4.8 2.1 1.6 -0.5 0.3 -0.7 -0.3 -1.3 -2.2 -2.0 -0.4 -0.0 0.6 -1.1
Supplements: Fish oil (including cod liver oil) 0.7 0.9 5.6 0.6 -1.4 -1.3 -0.4 -2.4 0.3 -0.1 -1.0 0.2 0.7 -0.5 0.5 -0.3
High cholesterol (Self-reported) 0.9 1.5 6.2 -2.5 0.2 1.0 1.8 -0.6 -0.2 -1.8 0.2 1.9 -1.1 0.3 -0.8 -0.5
Medication: Bendroflumethiazide 0.3 0.5 1.5 -0.2 1.0 -1.0 -0.0 0.6 0.3 -0.7 0.2 -0.0 -0.5 0.5 1.2 1.1
Medication: Paracetamol 0.5 0.8 3.2 0.9 1.2 -0.0 -0.1 0.3 0.9 -0.6 -0.2 -1.8 -0.1 1.8 -0.3 -0.3
Medication: Lisinopril 0.5 0.6 1.8 0.0 1.3 -0.3 -0.0 0.8 -0.2 0.4 -0.4 -0.6 -1.1 -0.9 1.3 0.7
Medication: Atorvastatin 1.6 2.0 6.7 -0.8 -0.8 -0.8 -0.6 2.6 1.6 -1.3 1.5 -0.3 0.8 2.1 1.7 1.5
Illnesses of father: High blood pressure 0.7 0.9 3.5 -1.9 1.3 -0.4 -0.3 -0.8 0.1 -1.1 -0.6 1.4 -0.6 -0.8 -1.1 0.0
Alcohol drinker status: Never 1.2 1.4 6.6 0.8 2.6 0.7 1.7 -0.3 -0.5 -0.4 -1.3 -1.5 -1.4 -0.6 0.6 -0.9
Ever smoked 0.5 0.9 3.2 -0.4 1.2 0.9 1.2 0.1 -1.3 -0.8 -1.0 0.2 -1.8 -1.0 0.6 -0.5
Basal metabolic rate 0.7 3.7 20.3 2.7 -0.6 1.1 0.5 4.5 -1.4 1.8 1.4 -2.3 0.5 1.5 1.4 1.1
Leg fat percentage (left) 0.8 2.9 8.6 -0.3 0.9 0.7 1.8 -2.3 -1.5 -2.4 -2.6 -0.5 -1.7 -1.1 -0.1 -2.9
Arm fat-free mass (left) 0.7 3.8 19.1 2.9 -0.4 1.4 0.8 4.4 -2.0 2.0 1.1 -2.3 0.3 1.0 1.5 1.0
Number of operations (self-reported) 1.0 1.5 6.3 1.2 -0.9 -1.3 -0.5 1.7 0.3 -1.1 1.2 -0.6 1.7 2.5 -0.5 0.2
Average weekly beer plus cider intake 1.6 2.3 8.3 -1.6 1.1 0.7 0.6 -1.7 -1.8 -1.3 -0.9 1.8 -0.4 -1.4 -2.9 -1.7
Irritability 0.8 1.3 4.9 -0.9 1.3 0.6 1.2 -0.7 -1.2 -1.7 -0.4 0.6 -2.2 -0.2 1.3 -1.0
Risk taking 1.1 1.6 7.3 1.7 0.3 0.4 -0.0 2.4 0.8 0.5 -0.5 -2.7 0.2 0.5 1.7 0.7
Ever had prostate specific antigen (PSA) test 1.1 1.2 3.1 -0.1 1.7 1.4 1.5 0.1 -1.3 0.1 -0.5 -1.3 -1.5 -1.2 1.0 -0.3
Fractured/broken bones in last 5 years 1.1 1.4 4.7 0.7 0.8 -0.0 1.1 -0.7 -0.8 -2.2 -1.3 -1.5 -1.0 0.8 1.3 -1.9
Age started oral contraceptive pill 1.5 1.8 5.5 0.5 -0.5 -1.6 -2.2 -0.0 1.5 2.4 0.9 0.5 1.6 0.1 -0.4 2.2
Diastolic blood pressure, automated reading 2.0 6.1 12.5 -3.5 2.8 1.6 2.1 -2.3 -2.2 -1.7 -2.1 2.1 -2.9 -2.4 -3.2 -2.4
Ever depressed for a whole week 2.0 2.4 10.0 1.1 -0.3 1.5 1.1 -1.2 -3.2 0.7 -1.1 -1.2 -0.6 -0.9 -2.3 -2.4
Unable to work because of sickness or disability 1.0 1.4 4.7 2.2 0.4 -0.7 -0.1 1.0 0.5 -1.4 -1.0 -1.9 0.3 1.1 1.7 0.0
Commuting to job workplace: Cycle 0.3 0.4 1.3 1.0 0.7 -0.7 -0.3 0.0 -0.0 0.7 -1.2 -0.5 -0.4 -0.9 0.3 0.2
Myopia 1.0 1.4 5.7 2.4 1.0 -1.0 -0.9 0.2 0.0 -0.1 -1.2 -2.1 0.3 -0.5 1.8 0.6
Vascular/heart problems diagnosed by doctor 1.6 4.5 7.7 2.8 -2.7 -1.4 -2.6 1.4 2.4 1.8 1.6 -1.6 2.7 2.6 1.3 1.8
Cholesterol lowering medication 0.4 0.5 2.2 0.2 0.7 -1.2 -0.0 0.0 1.1 -0.9 -0.1 -0.0 -0.3 0.7 1.5 0.4
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 3.4 1.2 -0.8 -1.2 -1.2 1.6 1.6 -0.7 0.1 0.1 1.0 1.8 1.9 1.6
Pain experienced in last month 0.7 1.2 4.0 -1.6 -1.0 0.6 0.8 -0.4 -1.4 0.8 0.6 2.0 -1.0 -1.6 -0.3 -0.8
Supplements: Calcium 0.6 0.6 2.5 0.6 1.6 -0.6 -0.4 1.3 0.8 0.5 -0.0 -1.1 -0.2 0.2 0.3 0.8
Basal cell carcinoma (self-reported) 0.9 1.0 7.8 1.5 1.0 0.3 0.1 -0.1 -0.7 0.8 -0.2 -0.9 0.3 -0.1 -2.8 -0.4
Heart attack/myocardial infarction (self-reported) 0.8 1.0 3.8 -1.2 0.9 2.0 1.4 -0.1 -1.1 -0.1 -0.0 0.9 -0.8 -0.5 -1.5 -0.3
Deep venous thrombosis (DVT) (self-reported) 2.1 2.7 8.4 0.0 2.0 2.5 2.9 0.7 -1.9 -1.1 -0.4 0.2 -2.3 -0.1 -1.1 -2.1
Heart disease (siblings) 0.3 0.3 1.4 -0.2 -0.8 -0.2 0.4 -0.8 -0.6 -0.4 -0.3 0.0 0.5 0.0 -0.6 -1.2
Alcohol drinker status: Previous 0.9 1.0 5.4 -0.2 -0.4 0.2 -0.7 0.8 -0.2 1.5 2.3 1.2 -0.1 1.0 -1.2 0.8
Pack years of smoking 0.8 1.2 3.2 1.3 1.1 0.4 0.9 -1.0 -0.2 -1.3 -1.7 -1.8 -0.5 0.6 -0.7 -1.4
Impedance of whole body 0.1 0.8 3.0 0.4 1.7 0.3 0.4 -0.4 0.2 -1.2 -1.0 -0.6 -1.6 -0.5 0.5 -0.8
Leg fat mass (left) 0.3 1.1 2.8 0.7 0.2 0.6 1.3 0.1 -1.3 -1.2 -1.6 -1.3 -0.8 -0.3 0.6 -1.7
Arm predicted mass (left) 0.8 4.0 20.2 2.9 -0.7 1.3 0.7 4.5 -2.0 2.2 1.4 -2.2 0.5 1.2 1.4 1.1