Hub : Genes

GRHL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.3740	0.1130	4.0e-03	0.114	NA	0.062	NA	0.128	3.0e-04	NA	6.5e-03	NA	1.3e-04
2	GTEx	Esophagus Mucosa	0.1630	0.0480	1.0e-03	0.008	NA	-0.002	NA	0.000	8.4e-02	NA	4.6e-01	NA	3.4e-01
3	GTEx	Skin Not Sun Exposed Suprapubic	0.2430	0.0770	3.4e-03	0.094	NA	0.115	NA	0.168	7.6e-06	NA	7.1e-07	NA	1.6e-09
4	GTEx	Skin Sun Exposed Lower leg	0.2800	0.0520	2.5e-08	0.165	NA	0.205	NA	0.198	1.4e-13	NA	8.2e-17	NA	2.9e-16
5	GTEx	Thyroid	0.1480	0.0490	1.7e-03	0.037	NA	0.019	NA	0.012	8.0e-04	NA	1.2e-02	NA	3.9e-02
6	TCGA	Colon Adenocarcinoma	0.1050	0.0450	3.7e-03	0.025	0.019	0.032	NA	0.019	1.3e-02	2.7e-02	6.1e-03	NA	2.7e-02
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0522	0.0265	9.4e-03	-0.001	0.012	-0.001	NA	-0.001	3.9e-01	1.4e-02	4.2e-01	NA	4.6e-01
8	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1830	0.0640	1.2e-05	0.038	0.125	0.113	NA	0.114	3.1e-03	1.3e-07	5.2e-07	NA	4.4e-07
9	TCGA	Pheochromocytoma and Paraganglioma	0.1270	0.0570	2.4e-03	0.083	0.077	0.081	NA	0.091	3.5e-04	5.7e-04	3.9e-04	NA	1.9e-04
10	TCGA	Prostate Adenocarcinoma	0.0515	0.0253	2.4e-03	0.047	0.023	0.018	NA	0.031	1.1e-05	1.8e-03	4.8e-03	NA	2.8e-04
11	TCGA	Stomach Adenocarcinoma	0.0990	0.0490	3.9e-03	0.040	0.023	0.008	NA	0.014	6.4e-04	8.1e-03	7.5e-02	NA	3.2e-02
12	TCGA	Testicular Germ Cell Tumors	0.2990	0.1170	3.6e-03	0.040	0.058	0.037	NA	0.053	1.5e-02	4.3e-03	1.8e-02	NA	5.8e-03
13	TCGA	Thyroid Carcinoma	0.1160	0.0470	4.5e-05	0.067	0.049	0.057	NA	0.055	4.4e-07	1.6e-05	3.2e-06	NA	4.9e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.2	0.4	1.9	-0.3	0.4	-0.5	-0.4	0.4	-0.8	-1.4	-0.3	0.6	0.3	0.8	-0.6	0.0
Bipolar Disorder or Schizophrenia	0.3	0.7	3.8	0.7	2.0	0.0	0.4	1.2	-1.2	0.0	-0.2	-0.5	-0.9	0.6	-0.2	0.4
Depressed Affect (Nagel 2018)	0.8	1.7	7.9	0.5	1.4	-0.7	0.7	1.7	-2.8	-1.3	-0.3	-0.2	-1.3	-0.4	1.9	-0.8
Depression (Nagel 2018)	0.4	0.6	5.4	0.0	-0.5	-0.4	-0.1	0.9	-0.8	-0.1	0.7	0.1	-0.3	-0.2	2.3	0.4
Intelligence (Savage-Jansen 2018)	0.3	0.8	4.8	0.6	-0.8	0.3	0.2	-0.2	0.2	1.4	1.3	0.1	-0.1	-0.3	2.2	0.9
Neuroticism (Nagel 2018)	0.6	1.3	6.9	0.2	0.7	-1.1	0.2	0.9	-2.6	-1.1	0.0	1.0	-0.9	-0.7	2.0	-0.6
Schizophrenia (2018)	0.5	1.1	4.7	1.1	2.2	0.4	0.9	1.3	-1.0	1.2	0.0	-1.1	-1.4	0.0	0.2	0.5
Schizophrenia vs Biploar Disorder	0.6	0.8	2.4	1.2	0.9	0.9	0.6	1.0	0.1	1.4	0.1	-1.5	-1.1	0.2	0.7	0.4
Worry (Nagel 2018)	0.5	1.0	4.5	-0.5	0.4	-0.6	-0.1	-0.6	-2.1	-0.7	-0.3	1.6	-0.6	-1.4	1.0	-1.0
Alzheimer’s Disease (in mother)	0.5	0.6	1.4	-0.6	0.8	-0.1	0.8	-0.8	-1.2	-0.7	-0.4	0.2	-0.7	-0.7	-0.9	-1.0
Alzheimer’s Disease (in father)	0.5	0.6	1.4	1.2	0.6	0.5	0.8	0.3	-0.6	0.4	-0.3	-0.6	-1.2	-0.4	1.0	-1.0
Alzheimer’s Disease (including proxy)	0.3	0.5	1.7	0.4	0.8	-0.3	0.6	-0.1	-0.8	-0.6	-0.6	-0.4	-1.0	-0.5	0.4	-1.3
Crohns Disease (2017)	0.4	0.8	2.4	-0.8	-1.1	-1.6	-0.9	-0.1	1.3	-0.1	0.5	0.2	0.9	0.8	0.7	1.1
Irritable Bowel Disease (IBD)	0.6	1.4	6.0	-1.7	-2.4	-1.0	-0.6	0.8	0.6	0.7	1.3	1.6	1.1	0.4	-0.5	0.7
Ulcerative Colitis (UC)	0.6	1.2	5.3	-1.5	-2.3	-0.2	-0.2	0.7	-0.1	1.1	1.3	1.7	0.9	0.0	-0.8	0.1
Major Depression (MDD)	0.6	0.7	2.9	0.0	-1.1	-0.6	-0.3	1.2	-0.9	0.7	1.7	0.7	0.4	1.2	0.0	0.2
Reaction Time	0.4	0.7	3.2	-0.5	0.9	0.9	0.6	-0.9	-0.4	0.4	-0.7	0.3	-0.7	-1.1	-1.8	-0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.8	4.6	1.3	0.3	0.9	1.1	0.0	-0.4	-0.0	0.5	-0.9	-1.0	0.3	2.1	0.4
Breast Cancer	4.4	10.7	22.9	0.7	-3.4	-4.0	-4.8	0.4	4.7	2.2	2.8	1.2	4.8	3.2	-2.0	3.7
Ovarian Cancer	0.5	0.6	3.7	-0.1	0.7	1.9	1.3	-1.0	0.2	0.1	-0.2	-0.3	-0.7	-0.3	-0.2	-0.6
Prostate Cancer	7.8	10.9	23.7	-1.2	4.9	2.9	4.3	-0.5	-4.0	-2.6	-4.0	-0.3	-4.3	-3.3	-2.9	-3.6
Age at First Birth	0.7	1.0	3.1	-0.8	-0.6	1.1	1.1	-1.7	-1.4	-1.8	-0.0	0.6	-0.3	0.4	-0.2	-1.3
Bipolar Disorder (2011)	1.9	1.9	6.9	0.0	0.0	0.0	0.0	0.0	-1.9	-2.6	-1.5	1.1	-1.1	-0.5	-1.7	-2.4
Body Mass Index (BMI) (2010)	0.5	0.7	2.6	1.0	0.9	0.4	0.6	1.1	0.9	1.0	-0.6	-1.6	-0.7	-0.3	0.4	-0.0
Coronary Artery Disease (CAD)	0.8	0.9	2.3	-1.4	-1.2	-0.3	-0.4	-0.2	1.2	0.7	1.0	1.5	0.8	0.2	-1.5	0.2
Crohns Disease (2012)	1.3	2.0	5.1	-2.1	-1.3	-2.2	-1.7	-0.5	2.1	0.6	0.4	1.7	1.5	-0.5	-1.1	0.8
Mean Putamen Volume	1.1	1.3	3.6	0.3	-0.2	-1.7	-0.9	1.0	0.9	1.4	1.6	0.7	1.5	0.5	-0.5	1.9
Fasting Glucose	0.7	0.9	2.1	0.6	-0.6	-1.2	-1.5	0.2	1.1	0.1	0.4	1.1	1.0	1.3	-1.1	0.7
HbA1C	2.1	2.4	6.7	0.6	-2.0	-1.1	-1.9	-0.1	1.9	1.8	2.0	0.1	1.1	2.6	0.8	1.4
HDL Cholesterol	0.7	1.1	3.0	0.2	-1.0	-0.5	-1.1	0.2	1.4	-0.6	0.7	-0.3	1.6	1.7	0.5	1.7
LDL Cholesterol	1.0	1.6	5.6	1.0	0.6	0.8	1.0	1.6	-1.2	-2.4	-1.3	-1.0	-1.1	0.5	1.7	-1.3
Lupus	0.6	0.9	3.9	-0.5	-0.2	0.9	0.6	-1.2	-1.2	0.7	0.0	0.7	-0.8	-0.9	-2.0	-1.2
Neuroticism (2016)	0.2	0.3	0.8	-0.1	-0.7	-0.7	0.3	0.3	-0.8	-0.6	0.4	0.4	-0.1	0.5	0.5	-0.9
Primary Biliary Cirrhosis	0.4	0.5	1.6	-0.2	0.2	1.0	0.5	0.2	-1.2	-1.3	-0.7	0.4	-0.8	-0.3	0.3	-0.8
Rheumatoid Arthritis	0.4	0.6	3.7	-0.3	0.3	0.6	0.5	0.9	0.5	-0.6	0.1	-0.8	-0.8	0.2	1.9	0.4
Schizophrenia (2014)	0.5	1.1	5.8	1.1	2.4	0.1	0.2	1.5	-0.7	0.5	-0.3	-1.4	-1.1	0.5	0.2	0.6
Triglycerides	1.3	2.1	6.4	1.2	1.7	2.2	2.5	2.2	-1.0	-0.1	-0.4	-1.5	-1.6	-0.2	0.6	-0.6
Type 2 Diabetes (T2D) (2012)	0.8	1.0	4.4	-0.7	0.1	0.8	0.8	0.2	-0.8	-0.9	-1.4	-0.0	0.4	-1.2	-2.1	-1.1
Ulcerative Colitis	1.0	1.5	4.2	-0.6	-1.9	0.4	-0.3	1.6	0.9	1.7	2.0	0.9	0.9	1.0	-1.1	0.9
Blood Eosinophil Count	0.4	3.0	8.9	-0.2	2.7	0.2	1.6	-0.8	-0.1	-3.0	-2.9	-0.7	-2.2	-1.4	0.3	-2.1
Blood Platelet Count	0.5	5.9	12.3	0.2	2.8	3.5	2.6	-1.1	-2.1	-2.1	-3.5	-1.5	-3.0	-2.3	-1.2	-3.1
Blood Red Count	0.2	1.8	7.1	0.5	-1.1	0.1	-0.6	1.5	-0.1	0.2	2.1	-0.4	1.8	2.0	-0.9	2.7
Blood White Count	0.3	2.3	6.7	-1.4	1.1	1.2	1.2	-2.6	0.4	-1.7	-2.3	-0.2	-1.0	-1.9	-1.1	-1.8
Heel T-Score	0.4	3.4	11.4	-2.8	0.9	0.8	0.7	-2.6	1.7	-3.4	-2.2	1.1	-1.7	-0.4	-1.1	-1.8
BMI	0.1	0.3	0.9	0.1	0.0	0.5	0.7	0.1	0.9	-0.1	-0.9	-0.9	0.1	-0.4	0.7	-0.4
Height	0.8	16.2	110.2	4.6	0.2	2.1	1.0	10.5	-3.2	3.6	4.0	-3.7	-0.1	2.6	2.6	2.8
Waist Hip Ratio (WHR)	0.3	1.3	9.5	0.9	0.9	0.8	0.3	3.1	-1.1	0.7	-1.1	-0.9	-0.2	-1.1	0.1	-0.1
Systolic Blood Pressure	1.1	5.6	16.4	-4.0	1.8	0.5	1.0	-3.4	-1.5	-0.5	-1.2	3.7	-1.6	-3.4	-2.5	-1.1
Smoking Status	0.4	0.9	2.6	-1.6	1.3	0.7	0.8	-0.4	-0.3	-1.2	-1.3	0.8	-1.1	-1.0	0.0	-0.5
Allergy or Eczema	1.4	3.6	8.8	1.4	-2.2	-3.0	-2.5	1.2	2.0	0.6	1.2	-0.5	2.9	1.9	0.8	2.1
Cardiovascular Disease	1.6	5.2	8.5	-2.4	2.9	1.2	2.5	-1.9	-2.7	-2.5	-2.4	1.2	-2.7	-2.5	-1.0	-2.3
Hypothyroidism (self reported)	0.1	0.3	1.2	0.1	-0.0	-1.1	-0.6	-0.2	-0.5	1.1	0.6	0.6	0.0	-0.5	-0.5	-0.1
Respiratory disease	0.9	1.9	11.6	1.2	1.9	-0.1	0.3	3.4	0.1	0.3	-0.4	-1.4	-0.6	-0.2	2.1	1.0
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.2	-0.8	-0.7	-1.5	-1.3	0.2	0.8	0.1	-0.0	0.9	1.3	-1.2	-0.4	1.5
Lung FEV1/FVC ratio	0.7	3.5	11.3	-3.0	0.2	1.8	1.7	-1.8	-1.4	-0.2	-0.4	2.7	-2.2	-3.4	0.3	-0.7
Lung FVC	0.2	0.9	3.9	-0.6	-0.5	0.1	-0.0	-0.5	-0.7	1.6	2.0	1.0	-0.0	0.9	-1.3	0.2
Neuroticism	0.5	1.3	8.3	0.3	0.6	-0.6	0.5	1.8	-2.9	0.2	0.5	0.4	-0.6	-0.7	1.7	-0.1
Chronotype (morning person)	0.5	1.1	3.8	-0.0	-1.4	0.1	0.1	1.8	0.4	-1.0	1.3	0.3	1.5	1.9	-0.2	0.5
Hair Pigment	0.0	0.4	3.0	0.1	-0.2	1.0	0.2	-0.6	0.6	-0.1	0.1	0.1	-0.5	0.3	0.2	1.7
Tanning	0.1	0.9	2.4	1.1	-1.1	-1.2	-1.6	0.1	1.1	1.4	1.0	-0.5	0.9	0.6	0.2	0.5
Hand grip strength (left)	0.2	0.5	1.5	0.9	-0.2	-0.1	-0.4	0.0	1.2	1.0	0.5	-1.0	-0.1	0.9	1.0	0.5
Number of treatments/medications taken	0.7	1.3	4.2	-0.1	1.9	1.1	1.4	0.9	-0.5	-2.0	-1.5	-0.5	-1.2	-0.2	-0.4	-0.8
Average weekly spirits intake	0.7	0.9	4.0	0.1	-0.5	-0.4	-1.3	0.7	2.0	0.7	0.6	-0.2	1.2	0.9	-0.5	1.0
Sensitivity / hurt feelings	0.4	0.6	2.8	1.2	0.3	0.0	0.6	0.5	-1.2	0.0	-0.5	-1.7	-0.1	-0.0	1.3	-0.4
Frequency of depressed mood in last 2 weeks	0.4	0.6	3.8	0.1	-0.3	-1.0	-0.4	1.0	-1.0	0.1	0.8	0.3	-0.1	-0.3	1.9	0.3
Hearing difficulty/problems: Yes	1.2	1.9	3.6	0.7	1.4	1.3	1.8	0.4	-1.9	-0.8	-1.7	-0.9	-1.7	-1.6	0.8	-1.6
Relative age of first facial hair	0.5	1.1	5.8	0.3	1.2	-0.7	0.0	2.4	-0.9	-1.2	0.7	0.6	-0.3	0.2	1.4	1.2
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	6.8	0.1	1.3	-0.3	0.8	-1.0	-1.2	-1.6	-2.6	0.4	-0.7	-1.8	-0.5	-2.0
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.7	0.3	-1.3	-1.1	-1.0	0.0	1.0	0.3	-0.2	0.3	1.0	0.7	0.6	-0.4
Ever had hysterectomy (womb removed)	0.6	0.6	3.4	0.3	0.1	-1.8	-0.0	1.2	0.3	-1.0	-0.3	0.4	-0.1	0.3	1.4	-0.1
Systolic blood pressure, automated reading	1.2	3.6	11.4	-3.4	0.8	0.2	0.3	-3.1	-0.7	-0.4	-0.9	3.2	-0.9	-2.1	-2.8	-0.6
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.6	0.5	0.2	-1.3	-1.2	1.2	0.7	-0.2	-0.4	-0.9	0.3	0.6	-0.4	0.2
Angina	0.1	0.2	1.0	-0.3	0.1	0.3	0.3	-0.4	0.2	0.0	0.4	0.2	0.2	0.7	-1.0	-0.0
Medication for hormone replacement therapy	0.4	0.4	1.5	-0.9	-0.7	-0.4	-0.6	-0.3	0.4	-0.8	-0.3	0.2	0.7	0.6	-0.3	-1.2
Vitamin and mineral supplements	0.6	0.8	4.2	0.1	0.4	2.0	1.1	0.8	-1.1	-0.6	-0.4	-0.2	-0.9	-0.4	1.1	-0.6
Supplements: Zinc	0.5	0.5	1.0	0.1	0.9	0.8	1.0	-0.5	0.2	-0.9	-0.4	-1.0	-0.9	0.7	0.3	-0.7
Medication: Co-codamol	0.5	0.6	1.6	0.6	0.5	0.1	1.0	0.5	-0.7	-1.1	-1.1	0.2	-0.3	-0.3	-1.3	-1.2
Medication: Metformin	0.9	1.3	4.4	-0.1	-1.3	-1.7	-1.2	0.7	0.9	0.5	1.2	1.0	1.5	0.1	-0.2	2.1
Diabetes (father)	2.1	2.6	5.9	-1.3	-2.2	-1.7	-1.8	-1.0	1.8	1.2	1.5	2.4	1.8	0.4	1.0	1.8
Diabetes (mother)	0.4	0.5	2.7	-0.3	-0.3	0.9	0.7	-0.5	-1.6	0.2	0.5	1.0	0.0	-0.9	-0.5	-0.1
Severe depression (siblings)	0.9	1.0	6.1	1.4	0.1	-0.4	0.1	0.3	-1.4	-0.9	-1.0	-1.0	-0.4	0.3	2.5	-0.6
Pack years adult smoking proportion	0.7	1.1	3.0	1.3	1.3	0.3	0.7	-1.0	-0.2	-1.1	-1.7	-1.7	-0.5	0.3	-0.7	-1.3
Impedance of leg (right)	0.3	1.5	3.8	0.5	1.8	1.4	1.5	-0.3	-1.2	-1.5	-1.0	-0.8	-1.9	-0.6	0.2	-1.4
Leg fat-free mass (left)	0.5	2.8	15.6	2.3	-0.9	0.4	-0.1	4.0	-0.8	1.7	1.4	-1.7	0.9	1.4	1.2	1.3
Trunk fat percentage	0.3	1.1	4.2	0.6	0.7	-0.3	0.5	-0.7	-0.1	-1.8	-2.0	-1.2	-0.9	-0.2	0.7	-1.5
Hand grip strength (right)	0.2	0.4	1.1	0.8	-0.3	0.6	0.2	0.1	0.4	0.8	0.6	-1.0	-0.3	1.1	0.9	0.3
Townsend deprivation index at recruitment	0.9	1.2	3.9	0.6	0.7	-1.3	-0.6	1.5	0.9	-2.0	-1.1	-1.3	-0.1	0.8	1.5	-0.5
Current tobacco smoking	0.3	0.5	4.0	-2.0	-0.2	0.0	-0.4	-0.3	0.8	-0.9	0.0	0.6	0.5	0.6	-0.3	-0.0
Average weekly fortified wine intake	1.3	1.6	6.9	1.2	0.9	1.1	0.8	2.0	-0.3	-0.6	-1.0	-1.6	-1.0	-0.6	2.6	0.1
Maternal smoking around birth	0.2	0.4	1.2	0.2	0.3	-1.1	-0.7	0.9	0.5	-0.8	0.2	-0.3	0.5	0.8	0.4	0.1
Fed-up feelings	0.4	0.7	2.2	0.9	0.5	-1.5	-0.3	1.0	-1.3	-0.7	0.0	-0.3	-0.3	0.5	1.4	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	2.5	0.4	-0.2	-0.9	-0.4	0.6	0.1	0.0	0.9	-0.0	0.1	0.3	1.6	1.0
Relative age voice broke	0.3	0.4	1.3	1.0	0.2	-0.2	0.3	1.2	-0.6	-0.4	1.0	0.3	-0.0	0.3	0.7	0.7
Taking other prescription medications	0.6	0.9	3.8	0.8	2.0	-0.6	0.3	1.2	-0.8	-0.2	-1.2	-0.9	-0.9	-0.9	1.0	0.1
Age when periods started (menarche)	0.4	0.9	2.9	-1.0	1.3	-0.3	0.2	1.4	-1.2	-1.1	0.1	0.2	-0.8	-0.2	1.7	0.2
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	2.8	-1.1	-0.7	-1.1	-0.3	-1.7	0.9	-1.3	-0.8	0.6	0.6	-0.1	0.9	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	6.1	-1.2	1.3	1.1	0.6	-0.9	0.1	-2.5	-2.4	0.0	-1.2	-0.8	-0.7	-1.8
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	1.5	-0.2	-1.0	-0.2	-0.7	-1.2	-0.1	0.7	-0.0	0.6	0.4	0.1	-0.9	-0.0
Qualifications: CSEs or equivalent	0.6	0.8	2.9	0.2	0.4	-1.7	-1.2	-0.0	1.5	0.6	-0.0	-0.5	0.8	0.4	-1.3	0.0
Serious illness, injury or assault to yourself	0.9	1.1	5.1	1.7	0.6	-0.4	-0.5	1.2	0.4	0.2	-0.8	-2.3	0.2	0.4	1.4	1.0
High blood pressure	1.3	3.7	7.4	-2.5	2.7	0.6	1.9	-1.1	-2.2	-1.7	-1.8	1.5	-2.5	-2.7	-0.8	-1.5
Hayfever, allergic rhinitis or eczema	0.6	1.4	3.2	1.1	-1.8	-1.8	-1.5	0.6	1.2	-0.3	0.3	-0.5	1.6	1.5	0.0	0.9
Multivitamins +/- minerals	0.4	0.6	3.9	-0.3	-0.2	-1.0	-0.1	-1.0	0.1	0.0	0.5	0.6	0.1	0.8	-2.0	-0.3
Stomach or abdominal pain in last month	0.4	0.5	1.7	0.7	1.0	0.7	0.5	1.3	0.1	-0.3	0.3	-0.9	0.2	1.1	-0.4	0.7
Supplements: Glucosamine	1.4	1.8	4.9	2.2	-1.5	-1.3	-1.4	0.4	0.7	1.4	0.8	-1.4	1.5	1.3	1.0	1.7
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.9	-0.6	-0.8	-0.8	-0.4	0.7	0.3	0.3	0.8	1.2	1.1	0.6	-1.4	1.0
Medication: Atenolol	1.0	1.3	5.6	-1.1	-0.0	0.9	1.6	-0.9	-0.6	-2.4	-1.2	0.8	-0.6	-0.4	1.4	-1.1
Medication: Levothyroxine sodium	0.2	0.3	0.8	0.9	0.6	-0.8	-0.2	0.8	-0.3	0.3	-0.1	-0.9	-0.2	-0.0	0.7	0.5
Sitting height	0.7	5.0	19.4	3.7	-0.3	1.2	0.8	4.4	-0.8	2.1	2.4	-2.0	0.4	2.4	1.3	2.5
Chronic bronchitis/emphysema (father)	0.5	0.6	3.4	0.3	1.9	-0.1	0.3	-1.0	0.9	-0.3	-0.6	-0.4	-1.1	-0.0	-1.0	0.1
High blood pressure (mother)	2.6	3.7	7.5	-2.6	1.6	1.4	2.1	-1.7	-2.7	-0.7	-1.1	1.9	-2.5	-2.7	-0.8	-1.6
Body mass index (BMI)	0.2	0.8	3.1	-0.3	-0.3	-0.4	0.3	-1.4	-0.3	-1.4	-1.8	-0.2	-0.0	-0.5	0.0	-1.6
Impedance of leg (left)	0.2	1.1	3.1	0.3	1.8	1.1	1.2	-0.3	-1.1	-1.1	-0.8	-0.7	-1.7	-0.6	-0.3	-1.2
Leg predicted mass (left)	0.5	2.8	15.8	2.3	-0.8	0.5	-0.0	4.0	-0.8	1.8	1.4	-1.7	0.8	1.4	1.1	1.4
Trunk fat mass	0.2	1.0	3.0	1.3	0.4	0.3	0.9	0.8	-0.7	-1.1	-1.4	-1.7	-0.7	0.1	1.1	-1.0
Waist circumference	0.2	0.6	2.0	1.1	-0.2	0.3	0.4	1.4	-0.9	0.1	-0.8	-1.4	0.3	-0.3	0.4	-0.6
Number of incorrect matches in round	0.4	0.6	5.1	1.1	0.1	-0.0	-0.4	-0.0	-0.5	2.2	0.2	-0.2	0.5	-1.1	0.0	0.5
Past tobacco smoking	0.5	0.9	3.2	-0.0	-1.3	-1.0	-1.2	0.1	1.0	1.0	1.2	0.2	1.8	0.8	-0.8	0.4
Alcohol usually taken with meals	0.9	1.5	4.4	0.7	-2.1	-0.6	-1.3	-0.2	1.2	1.6	1.7	-0.0	1.4	1.0	0.5	1.6
Nervous feelings	0.8	1.4	6.2	0.1	1.6	0.5	0.7	-1.2	-2.5	-0.6	-1.1	0.9	-1.2	-1.8	0.6	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.4	0.7	-0.9	-1.9	-0.9	0.7	0.4	-0.6	0.4	-0.5	0.7	1.0	1.8	0.8
Hearing difficulty/problems with background noise	0.4	0.6	3.2	-0.6	-0.4	-0.6	0.7	-0.1	-1.8	-0.4	0.2	1.1	-0.2	-0.4	-0.7	-0.9
Hair/balding pattern: Pattern 2	0.9	1.1	4.7	-2.2	-0.2	0.5	-0.1	-1.1	0.2	1.3	0.7	1.7	-0.3	-1.3	1.3	0.1
Had menopause	0.6	0.7	2.9	1.4	1.2	-0.0	0.3	0.1	0.1	0.6	-0.8	-1.7	-0.2	-0.2	1.2	0.6
Had other major operations	2.7	3.2	10.2	0.7	-2.4	-2.1	-1.4	1.0	1.1	0.9	3.2	0.3	2.4	2.7	0.6	1.6
Forced vital capacity (FVC)	0.8	3.2	11.1	2.4	-0.8	2.0	0.6	3.3	-1.0	2.2	2.6	-1.4	0.4	1.6	0.6	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	4.6	-0.9	1.7	1.6	1.1	-1.2	0.5	-1.8	-2.1	-0.4	-1.6	-0.6	-0.5	-2.0
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	7.2	1.3	-0.5	0.8	0.3	0.3	-2.7	-0.4	-1.2	-0.4	-0.5	-0.4	-1.4	-1.8
Qualifications: None of the above	0.4	0.8	2.3	1.0	1.2	1.5	1.1	0.2	-0.9	-0.7	-1.3	-1.0	-0.9	-0.3	0.1	-0.5
Financial difficulties in last 2 years	0.4	0.5	2.2	-0.2	0.2	-0.7	0.0	1.3	0.2	-1.5	-0.4	-0.2	-0.1	0.4	0.6	-0.9
Mouth/teeth dental problems	0.1	0.2	0.6	-0.0	0.8	0.6	0.6	0.1	0.5	0.4	0.2	0.1	-0.7	-0.4	0.2	0.2
Heart attack	1.0	1.3	4.9	-1.2	1.2	2.2	1.6	-0.2	-1.2	-0.1	-0.1	0.9	-1.1	-0.5	-1.5	-0.5
Allergy	0.8	1.8	4.3	-2.0	0.7	1.9	1.4	-2.1	-1.2	0.3	-0.2	1.3	-1.6	-1.7	-0.4	-0.8
Pain all over the body in last month	0.1	0.1	0.4	0.2	-0.2	-0.5	0.1	-0.7	0.2	-0.1	-0.0	0.2	-0.3	0.3	-0.3	0.0
Diabetes (self-reported)	0.8	1.2	3.8	-0.1	-0.4	-1.7	-1.2	1.2	1.2	0.9	1.3	0.5	1.3	0.2	-0.3	1.9
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	3.6	-1.0	-1.9	-1.5	-1.4	-0.9	1.8	-0.1	0.6	1.5	1.7	0.8	-1.9	0.5
Medication: Ramipril	0.5	0.6	1.7	-0.8	0.9	0.3	1.1	0.3	-1.3	-1.1	-0.5	0.1	-0.6	-0.9	-0.2	-0.9
Medication: Simvastatin	1.0	1.5	5.3	-0.2	1.2	1.8	2.3	-0.9	-0.7	-1.1	-1.2	0.8	-1.7	-1.2	-0.1	-0.9
Fluid intelligence score	0.3	0.6	1.6	0.8	0.8	0.8	0.8	-1.1	-0.1	0.7	-0.1	-0.5	-1.0	-0.6	1.3	-0.1
Illnesses of siblings	0.6	0.8	3.1	1.3	-0.9	1.0	-0.0	0.2	0.6	0.9	1.0	-0.5	0.3	1.8	0.2	1.0
Neuroticism score	0.5	1.0	6.6	-0.1	1.1	-0.8	0.3	0.3	-2.6	-0.7	-0.1	0.4	-0.9	-0.4	1.8	-0.6
Weight	0.3	1.4	6.4	1.9	-0.2	0.7	0.6	2.5	-1.1	0.3	-0.1	-1.9	-0.0	0.8	1.2	-0.1
Impedance of arm (right)	0.2	0.8	3.6	0.2	1.8	-0.2	-0.3	-0.3	1.9	-1.0	-0.9	-0.5	-1.2	0.0	0.6	-0.0
Arm fat percentage (right)	0.4	1.6	6.3	-0.4	0.7	-0.6	0.3	-1.9	0.7	-2.1	-2.5	-0.5	-0.8	-0.5	0.5	-1.8
Trunk fat-free mass	1.0	5.7	31.4	3.1	-0.7	1.6	0.8	5.6	-1.9	2.4	2.1	-2.5	0.5	1.8	1.6	1.5
Hip circumference	0.1	0.3	1.2	0.5	-0.5	0.2	0.6	0.1	-1.1	-0.4	-0.0	-0.4	-0.2	0.1	0.4	-0.8
Time employed in main current job	1.6	1.9	6.5	2.3	0.6	-1.0	-0.7	1.1	1.4	-0.5	-0.7	-2.5	0.4	1.7	1.8	0.4
Alcohol intake versus 10 years previously	0.5	0.7	1.9	0.1	1.4	0.3	0.2	0.3	-0.2	-0.5	-0.9	-0.9	-1.0	-1.0	1.2	-1.0
Father’s age at death	2.3	3.1	9.1	0.9	-2.0	-0.9	-1.6	1.3	1.2	2.5	3.0	0.2	2.4	1.2	0.3	2.5
Worrier / anxious feelings	0.6	1.2	2.7	-0.1	-1.6	-1.1	-0.7	0.9	-1.3	0.6	1.7	1.6	1.2	0.6	0.5	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.8	1.2	0.8	-1.3	-1.1	1.7	0.3	1.2	-0.1	-1.0	0.7	0.2	0.3	1.6
Falls in the last year	0.8	1.1	3.3	0.4	-0.6	-1.5	-0.7	1.0	1.2	-1.8	-0.6	-1.1	1.2	1.3	0.5	-0.2
Hair/balding pattern: Pattern 3	0.4	0.5	3.9	-0.1	-0.1	0.0	0.4	0.7	0.3	-2.0	0.3	-0.1	-0.1	1.4	0.5	0.1
Number of live births	0.5	0.8	3.0	0.7	0.3	-0.5	-0.3	1.2	0.3	1.7	0.8	0.0	0.1	-0.5	1.4	1.3
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	6.4	1.0	-0.2	2.5	1.4	1.9	-1.6	1.6	1.7	-0.2	-0.7	-0.0	0.2	0.6
Pulse rate	0.2	0.4	1.2	-0.8	-1.1	-0.0	-0.5	0.1	-0.1	1.1	0.9	0.7	0.3	-0.0	-1.0	0.2
Happiness	0.4	0.5	3.9	-0.0	0.4	0.1	0.1	0.1	-0.3	2.0	0.4	0.3	-0.4	-1.4	-0.6	0.0
Noisy workplace	0.5	0.6	4.4	-0.8	-0.4	0.1	0.2	-0.4	0.3	0.1	-0.3	0.6	0.2	-0.0	-2.1	-1.2
Qualifications: A levels/AS levels or equivalent	1.7	3.8	8.4	0.3	-2.0	-2.4	-2.4	0.2	2.4	0.9	2.4	0.8	2.2	2.9	-0.8	2.7
Serious illness, injury or assault of a close relative in last 2 years	3.3	3.8	13.1	-0.6	1.9	1.8	2.6	-1.3	-2.0	-1.2	-2.6	0.5	-1.8	-3.6	-0.6	-2.1
Mouth/teeth dental problems: Dentures	0.2	0.4	1.5	-0.3	-0.8	0.1	-0.2	0.2	-0.9	0.1	0.4	0.8	0.6	0.4	-1.2	-0.6
Asthma	1.7	3.3	13.0	1.7	3.6	0.5	1.5	2.2	-1.7	-0.2	-1.9	-1.8	-2.1	-1.7	1.5	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	5.1	1.0	0.5	-0.4	-0.9	2.3	0.4	-0.9	0.1	-1.6	0.5	0.7	0.6	0.6
Medication: Cholesterol lowering	1.6	2.6	5.3	-2.0	0.4	2.3	2.2	-0.6	-1.7	-1.3	-1.3	1.5	-1.6	-2.2	-0.6	-1.4
Depression (self-reported)	0.5	0.6	1.7	0.0	1.1	-0.8	0.4	1.3	-1.3	-0.6	-0.7	-0.2	-0.6	-1.0	0.6	-0.5
Medication: Lansoprazole	0.7	0.8	4.4	-1.0	1.0	0.1	0.1	-2.1	0.7	0.4	-0.4	0.6	0.1	-0.7	-1.6	-0.1
Prospective memory result	1.8	2.2	12.0	-1.4	-1.5	-0.6	-0.2	-0.3	-0.6	1.1	1.2	2.8	0.6	-0.3	-3.5	-0.3
Lung cancer (father)	0.8	1.0	4.5	1.5	0.8	0.5	0.7	1.1	-0.3	-0.9	-1.0	-2.1	-0.5	0.6	0.6	-0.7
Illnesses of mother	2.4	2.9	6.9	2.6	-1.3	-0.6	-1.5	1.9	2.4	1.0	0.9	-1.9	1.5	2.5	1.4	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	6.6	0.1	0.9	2.6	1.9	2.1	-2.1	1.8	1.7	0.2	-1.5	-0.6	-0.5	0.4
Pulse wave Arterial Stiffness index	0.3	0.4	1.2	-1.0	-0.2	-1.0	-0.7	-0.8	-0.1	-0.3	-0.1	0.1	0.1	-0.3	1.1	0.2
Impedance of arm (left)	0.1	0.7	2.8	0.7	1.3	-0.5	-0.5	-0.1	1.7	-0.8	-0.3	-0.8	-1.0	0.5	0.9	0.1
Arm fat mass (right)	0.1	0.5	2.2	0.4	0.3	-0.1	0.4	-0.0	-0.0	-0.9	-1.5	-1.1	-0.5	-0.1	0.9	-1.1
Trunk predicted mass	1.0	5.7	31.6	3.1	-0.6	1.7	0.9	5.6	-1.9	2.4	2.0	-2.6	0.4	1.7	1.7	1.5
Standing height	1.3	12.7	69.4	4.7	-0.3	2.2	0.6	8.3	-1.6	3.7	3.8	-3.4	0.1	2.8	2.8	3.2
Length of working week for main job	0.4	0.5	1.3	-1.0	0.2	-0.8	-0.1	-0.6	1.1	-1.1	-0.2	0.2	0.1	0.6	-1.1	-0.4
Exposure to tobacco smoke at home	4.7	5.2	11.8	-1.2	3.4	0.6	1.4	-1.4	-2.0	-3.3	-3.4	-0.6	-2.9	-2.1	0.2	-3.2
Breastfed as a baby	1.2	1.5	4.6	0.7	-1.6	0.2	-0.6	2.1	0.2	2.1	1.7	0.8	1.2	-0.2	-0.2	1.6
Tense / ‘highly strung’	2.2	3.6	9.8	0.3	2.6	1.3	2.1	1.0	-3.1	-1.2	-1.2	-0.9	-2.4	-2.1	2.7	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	4.4	0.2	1.2	0.2	0.8	-0.7	-2.1	-0.1	-0.4	0.5	-1.0	-0.7	-0.2	-1.3
Hair/balding pattern: Pattern 4	1.2	2.9	10.5	-0.8	0.3	1.4	1.6	-2.0	-2.1	-3.2	-1.6	0.0	-1.1	0.4	-2.0	-2.4
Birth weight of first child	1.8	3.3	16.0	2.2	-1.0	0.0	-0.6	4.0	1.4	1.5	1.6	-1.2	1.7	2.4	0.1	1.8
Peak expiratory flow (PEF)	1.2	2.7	12.2	0.0	0.6	3.5	2.5	-1.1	-2.5	-0.7	-0.9	0.0	-1.8	-1.5	0.1	-1.3
Pulse wave reflection index	0.3	0.4	2.8	-0.7	0.1	-0.6	-0.5	-1.7	-0.5	-0.1	-0.2	-0.0	0.3	-0.4	0.6	0.2
Ever highly irritable/argumentative for 2 days	0.6	0.7	3.3	0.6	-1.3	-0.3	-0.7	-0.0	0.2	0.8	-0.1	-0.1	1.5	0.3	-1.8	-0.7
Loud music exposure frequency	0.8	0.9	2.9	-0.4	1.7	0.0	0.6	0.2	-0.3	-0.3	-1.1	-1.3	-1.7	-0.5	0.8	-1.3
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	4.2	-1.2	-0.9	0.3	-0.8	0.0	2.1	0.1	1.2	0.6	0.7	1.3	-0.3	1.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.7	0.2	0.7	0.5	0.5	-0.0	-0.3	-1.3	-1.6	-1.1	-0.7	-0.6	0.7	-0.8
Blood clot in the leg (DVT)	2.1	2.8	8.7	0.1	2.1	2.7	3.0	0.9	-1.8	-0.7	-0.3	0.3	-2.3	-0.0	-1.2	-2.0
Medication: Paracetamol	0.5	0.8	3.7	1.5	0.9	-0.3	-0.7	1.0	0.2	-0.0	-0.6	-1.9	0.3	1.1	-0.7	-0.2
Headache pain in last month	0.7	1.3	4.9	1.1	2.1	-0.1	0.3	1.1	0.7	-0.6	-0.4	-2.2	-0.5	0.8	1.6	0.3
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	8.6	1.0	-1.5	-2.3	-2.6	0.3	2.6	1.1	1.9	-0.8	1.9	2.9	1.0	1.4
Glaucoma (self-reported)	0.4	0.5	2.1	-0.5	-1.1	-0.9	-0.9	-0.0	0.4	-0.4	0.4	0.5	1.5	0.1	-0.1	0.6
Gout (self-reported)	0.3	0.4	2.0	-0.6	0.7	-0.4	0.3	-0.1	-0.2	-1.4	-0.1	0.3	-0.1	0.6	-1.2	-0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.6	0.1	0.5	-0.9	0.1	0.3	-1.3	-0.1	-0.3	0.4	-0.4	-0.8	-0.3	-0.8
Medication: Amlodipine	2.4	3.4	9.8	-0.2	2.1	2.0	2.7	0.1	-2.6	-0.1	-1.5	0.2	-2.3	-3.1	-1.1	-1.8
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.6	1.1	1.9	0.2	-0.1	0.7	-0.2	-0.1	-1.3	-1.1	-1.4	-0.4	0.7	-0.2
Birth weight	1.0	2.2	13.2	-0.5	-1.6	0.6	0.6	3.6	-0.6	1.8	1.6	1.5	0.8	0.4	-1.7	0.4
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.0	0.2	0.3	-0.9	-0.3	-1.1	0.7	-1.3	-1.0	-1.0	0.2	0.3	1.4	-0.6
High blood pressure (siblings)	2.1	3.0	6.2	-1.9	2.5	-1.2	0.5	-1.2	-1.4	-2.1	-2.4	0.8	-1.8	-2.5	-1.0	-1.7
Forced vital capacity (FVC), Best measure	0.6	2.4	9.0	1.1	0.3	2.1	1.2	3.0	-1.4	2.0	2.5	-0.5	-0.4	1.0	-0.5	1.1
Body fat percentage	0.4	1.7	6.2	0.3	0.7	-0.1	0.9	-1.4	-0.4	-2.2	-2.5	-1.0	-1.1	-0.7	0.6	-2.0
Leg fat percentage (right)	0.9	3.1	8.8	-0.2	1.0	0.8	2.0	-2.1	-1.6	-2.5	-2.7	-0.6	-1.9	-1.1	0.2	-3.0
Arm fat-free mass (right)	0.9	4.8	24.7	3.0	-0.9	1.2	0.6	5.0	-2.3	2.7	1.9	-2.1	0.6	1.1	1.4	1.4
Exposure to tobacco smoke outside home	0.5	0.6	2.1	0.4	1.3	1.5	1.0	0.1	-0.7	0.2	-0.3	-1.3	-0.5	-0.2	0.5	-0.3
Comparative body size at age 10	0.9	2.6	12.2	-2.7	-1.5	-0.9	0.0	-2.4	0.1	-0.3	0.1	3.5	0.4	-1.6	-1.6	-0.5
Number of full brothers	0.3	0.4	2.3	-0.3	0.1	-0.7	-0.3	1.5	-1.1	-0.3	-0.3	0.4	0.1	-0.2	0.3	0.1
Worry too long after embarrassment	0.2	0.3	1.5	0.1	0.9	-0.1	0.5	0.2	-1.2	-0.3	-0.3	0.1	-0.5	-0.3	1.0	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	4.0	1.1	0.4	-0.1	0.1	-0.4	-2.0	-0.5	-0.4	-0.4	-0.2	0.8	0.6	-1.0
Wheeze or whistling in the chest in last year	0.7	1.2	5.8	1.0	2.4	-0.6	0.4	0.6	-0.2	-0.3	-1.6	-1.5	-1.1	-0.7	0.9	-0.4
Number of children fathered	1.0	1.1	3.6	-0.9	1.8	0.1	1.2	0.3	-1.1	-1.5	-0.8	0.4	-1.9	-0.8	0.8	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	4.0	-0.1	0.4	-0.9	-1.3	0.8	2.0	0.5	0.8	0.4	0.5	1.3	1.0	1.8
Age at first live birth	0.6	1.1	4.4	-2.0	-0.9	-0.0	-0.0	0.3	-0.4	0.3	1.4	2.1	0.2	-0.3	-1.1	0.8
Pulse wave peak to peak time	0.4	0.4	1.9	1.0	0.3	1.1	0.7	1.4	-0.1	0.5	0.2	-0.1	-0.2	0.2	-0.8	-0.0
Health satisfaction	0.1	0.2	0.5	0.2	0.6	-0.5	-0.5	0.5	-0.7	-0.1	-0.5	0.2	-0.2	-0.4	0.2	0.1
Shortness of breath walking on level ground	0.7	0.8	3.1	0.8	0.3	-1.6	-0.4	1.1	0.7	0.3	-0.6	-1.0	0.1	-0.5	1.8	0.1
Qualifications: College or University degree	0.1	0.5	2.6	-0.8	-0.2	-0.7	-0.1	-0.4	-0.2	-1.6	-0.5	0.8	-0.2	0.2	0.8	0.4
Eye problems/disorders: None of the above	0.8	0.9	3.2	-0.9	-0.1	0.8	0.3	-1.8	-1.2	0.7	0.2	1.4	-0.1	-1.2	-1.2	-0.7
Mouth/teeth dental problems: Loose teeth	0.4	0.5	3.8	-0.5	0.3	-0.5	-0.2	0.4	-0.2	-0.3	-0.3	0.1	-0.6	-0.9	1.9	0.6
Emphysema/chronic bronchitis	1.3	1.5	4.8	1.8	-0.3	-1.3	-1.2	0.9	0.4	-1.2	-1.2	-2.2	1.4	1.0	0.9	-0.6
Medication for pain relief, constipation, heartburn	0.3	0.6	2.1	-0.6	-1.1	-0.1	0.0	-1.5	-0.8	0.5	0.7	1.4	0.0	-0.5	0.6	0.1
Neck or shoulder pain in last month	1.2	1.7	5.3	0.1	0.8	-2.3	-1.6	0.9	1.8	-1.3	-0.1	-1.3	1.4	1.7	-0.0	1.3
Medication: Blood pressure	1.0	1.7	4.8	-0.7	1.1	1.6	1.9	0.6	-2.1	-0.9	-0.9	0.7	-1.3	-2.2	-0.8	-0.8
Angina (self-reported)	0.1	0.2	0.6	-0.4	0.2	0.2	0.3	-0.5	0.4	-0.2	0.2	0.2	0.1	0.8	-0.7	-0.1
Migraine (self-reported)	0.5	0.6	1.6	-0.4	1.0	0.8	0.9	0.1	0.3	-0.7	-0.9	-0.4	-0.7	-1.3	1.1	-0.1
Medication: Ibuprofen	0.5	0.6	3.2	0.8	1.0	0.2	-0.1	1.8	0.0	-0.9	0.3	-1.2	-0.1	0.8	0.4	0.2
Medication: Allopurinol	0.7	1.0	3.3	-0.5	0.5	0.5	0.8	-1.4	-0.4	-1.8	-1.0	0.5	-0.7	0.3	-1.4	-1.4
Medication: Omeprazole	1.3	1.5	7.1	1.6	-0.3	-0.8	-0.3	1.7	1.0	-1.4	-0.7	-0.7	0.0	1.4	2.7	0.8
Medication: Seretide 50 evohaler	0.8	1.0	3.5	0.6	0.9	-1.4	-0.4	-0.6	0.5	-0.3	-1.4	-1.9	0.2	-0.4	1.7	0.4
Mean time to correctly identify matches	0.3	0.6	2.4	-0.9	0.4	0.9	0.9	-0.6	-0.6	0.2	-0.1	0.9	-0.5	-1.0	-1.6	-0.5
Heart disease (mother)	2.8	3.4	8.2	-2.1	-0.0	0.1	0.7	-2.9	-2.6	-1.4	-0.9	2.4	-0.3	-1.9	-2.4	-2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	8.6	2.9	1.3	-0.8	-0.8	0.2	0.9	0.7	-1.8	-2.6	-0.4	-1.2	1.8	0.7
Whole body fat mass	0.3	1.1	3.5	0.9	0.4	0.4	1.0	0.2	-0.8	-1.4	-1.9	-1.6	-0.8	-0.3	0.9	-1.4
Leg fat mass (right)	0.3	1.3	3.2	0.9	0.3	0.8	1.4	0.1	-1.4	-1.4	-1.7	-1.4	-1.0	-0.3	0.8	-1.8
Arm predicted mass (right)	0.9	4.6	22.6	3.1	-0.8	1.2	0.6	4.8	-2.1	2.3	1.8	-2.3	0.6	1.3	1.8	1.4
Pulse rate, automated reading	0.3	1.0	5.1	-1.5	0.2	0.7	0.3	-2.2	-1.0	-0.4	-0.0	1.1	-0.8	-0.5	-1.2	-0.5
Alcohol intake frequency.	0.4	0.9	3.3	-0.1	1.3	0.7	1.1	-0.1	-1.8	-0.7	-0.4	-0.3	-1.3	-0.6	0.3	-1.6
Comparative height size at age 10	1.3	7.1	35.0	2.7	-1.3	1.5	0.6	5.9	-0.0	3.9	4.1	-1.3	0.9	1.9	0.6	2.8
Number of full sisters	0.7	0.9	5.3	1.6	-0.3	-0.7	-0.6	2.3	-0.3	0.7	0.7	-0.2	0.6	0.8	-0.3	0.7
Suffer from ‘nerves’	0.9	1.4	2.6	-0.4	1.6	-0.2	0.8	-1.6	-1.5	-0.8	-0.7	1.2	-1.6	-1.3	-0.7	-1.6
Overall health rating	0.6	1.2	2.5	1.3	1.4	-1.0	-0.1	1.1	0.6	-1.5	-1.4	-1.5	-0.2	0.1	1.6	0.3
Chest pain or discomfort	0.4	0.6	2.1	1.0	1.2	0.0	0.9	0.3	-0.7	-1.4	-0.9	-0.9	-0.3	0.2	0.1	-0.6
Had major operations	1.4	1.7	5.8	-0.0	0.8	2.2	2.4	0.2	-1.7	-0.4	-0.3	-0.2	-1.2	-0.2	-1.4	-1.9
Age at last live birth	0.9	1.3	5.7	-1.8	-0.4	0.7	0.1	0.1	-0.5	1.3	1.9	2.4	-0.2	0.0	-0.8	0.8
Family relationship satisfaction	0.6	0.8	2.1	1.1	-0.5	-0.9	-1.5	1.2	0.8	0.8	-0.1	-0.8	1.2	0.4	-0.2	0.1
Leg pain on walking	0.3	0.4	1.4	-0.1	-0.3	-0.1	0.2	-0.6	0.1	-1.2	-0.6	0.4	0.0	1.0	-1.0	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.6	-0.3	-0.5	-1.1	0.0	0.1	0.2	-0.2	1.3	0.2	-0.0	1.0	-0.2	-0.4
Commuting to job workplace: Car/motor vehicle	0.7	0.8	5.1	1.2	0.9	-0.0	0.1	0.0	1.4	0.1	-0.3	-2.2	-0.2	0.7	0.5	0.8
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.8	0.2	0.3	-1.0	-0.7	-0.1	-0.1	-0.3	0.6	-0.8	-0.7	1.7	0.3	-0.3
Medication: Aspirin	0.5	0.7	1.8	1.0	1.1	1.3	1.3	0.4	0.0	0.3	-0.9	-1.1	-0.9	-0.4	-0.6	-0.1
Supplements: Vitamin C	0.3	0.4	1.2	0.6	-0.1	-0.8	-0.8	-1.1	0.1	0.3	-0.7	-0.5	0.3	-0.8	0.1	-0.3
Knee pain experienced in last month	1.5	2.4	5.0	1.7	2.1	1.0	1.4	0.7	-2.2	-1.4	-2.0	-1.8	-1.3	-0.9	1.2	-1.4
Hypertension (Self-reported)	1.3	3.7	8.9	-2.2	3.0	0.6	2.1	-1.1	-2.3	-1.9	-1.8	1.1	-2.6	-2.3	-1.0	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	5.3	0.6	-0.2	-1.2	-0.9	1.6	1.6	-1.0	0.6	-0.5	1.1	2.3	1.6	1.9
Illnesses of father: Heart disease	2.5	3.5	8.1	-2.1	1.8	1.2	1.7	-2.3	-2.8	-1.7	-1.3	1.5	-2.1	-2.1	-0.9	-2.0
Illnesses of siblings: Diabetes	1.9	2.3	5.7	1.5	-1.4	-1.3	-1.6	2.1	0.9	0.7	0.4	-1.2	2.4	-0.2	1.8	2.2
Smoking status: Previous	0.8	1.3	4.5	0.6	1.8	0.8	1.1	-0.4	-1.6	-0.6	-1.3	-0.2	-2.1	-1.0	0.8	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	8.8	1.1	-1.0	-0.4	-0.6	3.0	0.6	1.4	2.1	-0.5	0.6	2.0	0.8	1.8
Whole body fat-free mass	0.8	4.6	25.3	2.9	-0.7	1.2	0.5	5.0	-1.6	2.3	1.9	-2.3	0.6	1.6	1.5	1.5
Leg fat-free mass (right)	0.5	2.9	15.0	2.2	-1.0	0.2	-0.4	3.9	-0.5	2.1	1.6	-1.6	1.1	1.4	0.9	1.6
Arm fat percentage (left)	0.4	1.6	6.2	-0.0	0.6	-0.5	0.4	-1.7	0.5	-2.1	-2.5	-0.9	-0.8	-0.5	0.8	-1.9
Average weekly red wine intake	3.2	4.7	8.9	-2.0	-2.9	-1.5	-2.1	-1.2	2.0	1.6	3.0	2.8	2.4	1.5	-2.3	2.0
Handedness (chirality/laterality): Left-handed	1.3	1.5	4.2	0.2	-1.2	-0.6	-1.5	0.7	2.0	2.0	1.6	-0.2	1.5	0.8	0.0	1.3
Mood swings	0.3	0.6	2.6	0.6	0.7	-0.6	-0.2	0.4	-1.0	0.6	0.7	0.5	-0.7	0.1	1.6	0.7
Loneliness, isolation	0.9	1.3	3.6	0.1	1.3	-0.9	0.4	1.4	-1.9	-1.6	-0.7	-0.2	-1.2	-0.4	1.6	-1.1
Long-standing illness, disability or infirmity	1.1	1.7	3.8	1.9	1.3	-0.8	-0.3	1.5	0.0	-1.8	-1.6	-1.9	0.3	1.8	-0.8	-0.3
Ever had bowel cancer screening	0.2	0.3	0.6	-0.2	0.8	-0.2	-0.0	-0.5	-0.7	-0.1	-0.7	0.1	-0.5	-0.8	0.7	0.5
Diabetes diagnosed by doctor	0.9	1.5	4.5	0.5	-0.8	-1.8	-1.4	1.7	1.0	0.7	1.2	-0.3	1.7	0.4	0.0	2.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	0.9	-0.9	0.1	0.3	0.6	-0.3	0.4	0.1	-0.5	0.4	0.0	0.4	-0.4
Friendships satisfaction	0.9	1.1	6.0	1.7	0.4	0.1	-0.8	1.0	0.1	2.4	0.2	-1.2	0.5	-0.4	-1.1	0.6
Qualifications: nursing, teaching	0.2	0.3	0.6	0.7	0.4	0.7	0.7	-0.4	0.4	0.2	0.4	-0.8	-0.4	0.6	-0.3	0.7
Commuting to job workplace: Walk	0.8	0.9	3.1	1.5	0.2	0.2	0.0	0.5	-1.2	-0.9	-1.2	-1.2	-0.3	-0.0	1.8	-0.7
Eye problems/disorders: Cataract	0.7	0.8	2.0	0.5	1.4	-0.3	0.4	0.1	0.7	-1.0	-1.2	-1.4	-1.3	0.6	0.8	0.0
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.7	-0.2	-0.1	0.1	0.1	0.6	-0.2	-0.5	0.3	-0.0	0.1	-0.3	0.7	0.8
Medication for cholesterol	0.4	0.6	2.5	0.6	-1.6	0.3	-0.1	0.6	-0.3	1.4	0.9	-0.2	0.8	-0.9	0.8	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.6	-0.0	0.9	-0.1	0.2	1.3	0.7	-0.6	0.1	-0.3	-0.4	1.2	-0.5	-0.3
Back pain experienced in last month	0.1	0.1	0.5	-0.6	0.3	0.0	0.6	-0.5	0.0	0.1	0.5	0.3	0.0	-0.1	-0.7	-0.0
Mineral and other dietary supplements	0.5	0.7	2.8	-1.4	0.6	1.7	0.7	1.5	-0.2	-0.4	0.5	0.5	-0.8	-0.1	-0.3	-0.3
Breast cancer (self-reported)	2.2	2.6	14.1	2.3	1.2	1.5	0.5	0.8	-1.5	0.8	-1.2	-3.8	-1.1	-0.8	1.8	-0.7
Asthma (self-reported)	1.9	3.9	14.4	1.6	3.8	0.4	1.4	2.4	-1.8	-0.5	-2.4	-1.9	-2.3	-1.9	1.6	-0.6
Osteoporosis (self-reported)	2.8	3.4	16.1	0.5	-0.8	-1.6	-1.5	4.0	1.4	2.3	2.5	0.2	1.3	1.1	1.0	2.3
Osteoarthritis (self-reported)	1.4	1.9	4.2	1.2	1.5	1.6	1.7	-0.6	-0.9	-1.6	-1.8	-1.5	-1.3	0.2	-0.3	-2.1
Medication: Aspirin	0.6	0.8	2.2	0.2	1.4	1.3	1.5	0.2	-0.2	0.0	-1.2	-0.3	-1.3	-1.2	-0.5	-0.3
Medication: Gliclazide	1.0	1.1	2.2	-1.1	-1.4	-0.8	-1.0	0.8	0.7	0.6	1.2	1.5	1.4	0.7	-0.7	1.4
Illnesses of father: None of the above (group 1)	0.5	0.7	2.1	1.1	-0.9	0.7	0.3	1.4	-1.1	0.4	-0.1	-1.4	0.4	0.1	-0.2	-0.6
Smoking status: Current	0.3	0.5	3.5	-1.9	-0.3	0.2	-0.3	0.1	0.9	-0.9	-0.1	0.3	0.6	0.4	-0.3	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	5.7	-0.9	0.6	1.5	1.6	0.1	-2.4	-0.0	-0.1	1.2	-1.2	-1.6	-1.1	-1.1
Whole body water mass	0.8	4.8	25.7	3.0	-0.8	1.2	0.5	5.1	-1.6	2.2	1.8	-2.4	0.7	1.8	1.6	1.5
Leg predicted mass (right)	0.5	2.9	15.2	2.2	-1.0	0.2	-0.3	3.9	-0.6	2.2	1.6	-1.6	1.1	1.4	0.9	1.6
Arm fat mass (left)	0.2	0.7	2.1	0.8	0.3	0.1	0.6	0.2	-0.1	-0.9	-1.4	-1.4	-0.5	0.2	1.1	-1.2
Number of self-reported non-cancer illnesses	0.6	1.1	4.5	-0.2	2.1	-0.5	1.2	0.7	-0.3	-2.0	-1.2	-0.4	-1.0	0.3	-0.7	-0.4
Average weekly champagne plus white wine intake	0.5	0.7	4.7	0.7	-1.1	-0.2	-0.2	-0.1	-0.4	-1.1	0.0	-0.1	0.7	0.7	2.2	0.2
Miserableness	0.8	1.4	8.3	0.4	1.7	-0.4	1.2	-0.3	-2.9	-1.3	-0.4	-0.5	-1.0	-0.2	0.7	-1.1
Guilty feelings	1.1	1.7	6.0	-0.8	-1.5	-1.6	-0.6	1.1	-0.3	0.4	1.9	1.3	1.0	0.3	2.5	1.5
Wears glasses or contact lenses	0.5	0.6	1.5	0.5	-0.0	0.9	1.1	0.7	-1.2	0.6	1.2	0.1	-0.0	0.4	-0.9	-0.6
Ever taken oral contraceptive pill	0.3	0.3	0.9	-0.8	0.4	-0.2	-0.1	-0.8	-0.2	-0.7	-0.5	0.8	-0.1	-0.6	-0.9	-0.6
Hearing aid user	1.3	1.4	2.6	1.6	1.4	1.4	1.4	0.4	-1.6	0.5	-0.5	-1.6	-1.1	-0.6	1.4	-0.8
Mother’s age at death	1.3	1.6	4.3	-0.3	-2.1	-0.9	-1.5	-0.9	1.2	1.5	1.6	0.7	1.4	0.8	-0.5	1.9
Financial situation satisfaction	0.4	0.5	1.5	0.3	-0.3	-0.8	-1.0	0.3	0.2	1.2	0.9	0.7	0.6	-0.0	-1.0	0.5
Tinnitus: Yes, now most or all of the time	0.3	0.4	2.1	-0.3	0.3	-0.2	0.3	-0.2	0.0	-1.5	0.3	1.1	-0.4	0.8	-0.2	0.4
Commuting to job workplace: Public transport	1.8	2.1	7.6	-1.6	-2.0	-0.4	-1.1	-0.2	1.0	-0.6	1.6	2.8	1.8	1.8	-1.4	0.3
Eye problems/disorders: Glaucoma	0.6	0.7	2.5	-1.6	-0.1	-0.7	0.1	-0.3	-0.3	-1.6	-0.8	0.7	0.2	-0.6	-0.9	-1.1
Medication: Blood pressure	0.6	1.1	5.9	-0.2	2.4	0.2	1.2	-0.8	-0.7	-0.9	-1.0	-0.2	-1.7	-0.1	-0.9	-0.7
Pain type(s) experienced in last month: Hip pain	1.2	1.5	4.8	2.1	1.6	-0.5	0.3	-0.7	-0.3	-1.3	-2.2	-2.0	-0.4	-0.0	0.6	-1.1
Supplements: Fish oil (including cod liver oil)	0.7	0.9	5.6	0.6	-1.4	-1.3	-0.4	-2.4	0.3	-0.1	-1.0	0.2	0.7	-0.5	0.5	-0.3
High cholesterol (Self-reported)	0.9	1.5	6.2	-2.5	0.2	1.0	1.8	-0.6	-0.2	-1.8	0.2	1.9	-1.1	0.3	-0.8	-0.5
Medication: Bendroflumethiazide	0.3	0.5	1.5	-0.2	1.0	-1.0	-0.0	0.6	0.3	-0.7	0.2	-0.0	-0.5	0.5	1.2	1.1
Medication: Paracetamol	0.5	0.8	3.2	0.9	1.2	-0.0	-0.1	0.3	0.9	-0.6	-0.2	-1.8	-0.1	1.8	-0.3	-0.3
Medication: Lisinopril	0.5	0.6	1.8	0.0	1.3	-0.3	-0.0	0.8	-0.2	0.4	-0.4	-0.6	-1.1	-0.9	1.3	0.7
Medication: Atorvastatin	1.6	2.0	6.7	-0.8	-0.8	-0.8	-0.6	2.6	1.6	-1.3	1.5	-0.3	0.8	2.1	1.7	1.5
Illnesses of father: High blood pressure	0.7	0.9	3.5	-1.9	1.3	-0.4	-0.3	-0.8	0.1	-1.1	-0.6	1.4	-0.6	-0.8	-1.1	0.0
Alcohol drinker status: Never	1.2	1.4	6.6	0.8	2.6	0.7	1.7	-0.3	-0.5	-0.4	-1.3	-1.5	-1.4	-0.6	0.6	-0.9
Ever smoked	0.5	0.9	3.2	-0.4	1.2	0.9	1.2	0.1	-1.3	-0.8	-1.0	0.2	-1.8	-1.0	0.6	-0.5
Basal metabolic rate	0.7	3.7	20.3	2.7	-0.6	1.1	0.5	4.5	-1.4	1.8	1.4	-2.3	0.5	1.5	1.4	1.1
Leg fat percentage (left)	0.8	2.9	8.6	-0.3	0.9	0.7	1.8	-2.3	-1.5	-2.4	-2.6	-0.5	-1.7	-1.1	-0.1	-2.9
Arm fat-free mass (left)	0.7	3.8	19.1	2.9	-0.4	1.4	0.8	4.4	-2.0	2.0	1.1	-2.3	0.3	1.0	1.5	1.0
Number of operations (self-reported)	1.0	1.5	6.3	1.2	-0.9	-1.3	-0.5	1.7	0.3	-1.1	1.2	-0.6	1.7	2.5	-0.5	0.2
Average weekly beer plus cider intake	1.6	2.3	8.3	-1.6	1.1	0.7	0.6	-1.7	-1.8	-1.3	-0.9	1.8	-0.4	-1.4	-2.9	-1.7
Irritability	0.8	1.3	4.9	-0.9	1.3	0.6	1.2	-0.7	-1.2	-1.7	-0.4	0.6	-2.2	-0.2	1.3	-1.0
Risk taking	1.1	1.6	7.3	1.7	0.3	0.4	-0.0	2.4	0.8	0.5	-0.5	-2.7	0.2	0.5	1.7	0.7
Ever had prostate specific antigen (PSA) test	1.1	1.2	3.1	-0.1	1.7	1.4	1.5	0.1	-1.3	0.1	-0.5	-1.3	-1.5	-1.2	1.0	-0.3
Fractured/broken bones in last 5 years	1.1	1.4	4.7	0.7	0.8	-0.0	1.1	-0.7	-0.8	-2.2	-1.3	-1.5	-1.0	0.8	1.3	-1.9
Age started oral contraceptive pill	1.5	1.8	5.5	0.5	-0.5	-1.6	-2.2	-0.0	1.5	2.4	0.9	0.5	1.6	0.1	-0.4	2.2
Diastolic blood pressure, automated reading	2.0	6.1	12.5	-3.5	2.8	1.6	2.1	-2.3	-2.2	-1.7	-2.1	2.1	-2.9	-2.4	-3.2	-2.4
Ever depressed for a whole week	2.0	2.4	10.0	1.1	-0.3	1.5	1.1	-1.2	-3.2	0.7	-1.1	-1.2	-0.6	-0.9	-2.3	-2.4
Unable to work because of sickness or disability	1.0	1.4	4.7	2.2	0.4	-0.7	-0.1	1.0	0.5	-1.4	-1.0	-1.9	0.3	1.1	1.7	0.0
Commuting to job workplace: Cycle	0.3	0.4	1.3	1.0	0.7	-0.7	-0.3	0.0	-0.0	0.7	-1.2	-0.5	-0.4	-0.9	0.3	0.2
Myopia	1.0	1.4	5.7	2.4	1.0	-1.0	-0.9	0.2	0.0	-0.1	-1.2	-2.1	0.3	-0.5	1.8	0.6
Vascular/heart problems diagnosed by doctor	1.6	4.5	7.7	2.8	-2.7	-1.4	-2.6	1.4	2.4	1.8	1.6	-1.6	2.7	2.6	1.3	1.8
Cholesterol lowering medication	0.4	0.5	2.2	0.2	0.7	-1.2	-0.0	0.0	1.1	-0.9	-0.1	-0.0	-0.3	0.7	1.5	0.4
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	3.4	1.2	-0.8	-1.2	-1.2	1.6	1.6	-0.7	0.1	0.1	1.0	1.8	1.9	1.6
Pain experienced in last month	0.7	1.2	4.0	-1.6	-1.0	0.6	0.8	-0.4	-1.4	0.8	0.6	2.0	-1.0	-1.6	-0.3	-0.8
Supplements: Calcium	0.6	0.6	2.5	0.6	1.6	-0.6	-0.4	1.3	0.8	0.5	-0.0	-1.1	-0.2	0.2	0.3	0.8
Basal cell carcinoma (self-reported)	0.9	1.0	7.8	1.5	1.0	0.3	0.1	-0.1	-0.7	0.8	-0.2	-0.9	0.3	-0.1	-2.8	-0.4
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.8	-1.2	0.9	2.0	1.4	-0.1	-1.1	-0.1	-0.0	0.9	-0.8	-0.5	-1.5	-0.3
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	8.4	0.0	2.0	2.5	2.9	0.7	-1.9	-1.1	-0.4	0.2	-2.3	-0.1	-1.1	-2.1
Heart disease (siblings)	0.3	0.3	1.4	-0.2	-0.8	-0.2	0.4	-0.8	-0.6	-0.4	-0.3	0.0	0.5	0.0	-0.6	-1.2
Alcohol drinker status: Previous	0.9	1.0	5.4	-0.2	-0.4	0.2	-0.7	0.8	-0.2	1.5	2.3	1.2	-0.1	1.0	-1.2	0.8
Pack years of smoking	0.8	1.2	3.2	1.3	1.1	0.4	0.9	-1.0	-0.2	-1.3	-1.7	-1.8	-0.5	0.6	-0.7	-1.4
Impedance of whole body	0.1	0.8	3.0	0.4	1.7	0.3	0.4	-0.4	0.2	-1.2	-1.0	-0.6	-1.6	-0.5	0.5	-0.8
Leg fat mass (left)	0.3	1.1	2.8	0.7	0.2	0.6	1.3	0.1	-1.3	-1.2	-1.6	-1.3	-0.8	-0.3	0.6	-1.7
Arm predicted mass (left)	0.8	4.0	20.2	2.9	-0.7	1.3	0.7	4.5	-2.0	2.2	1.4	-2.2	0.5	1.2	1.4	1.1