Hub : Genes

ADAM17

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1390	0.0360	9.4e-09	0.080	0.090	0.129	NA	0.102	5.9e-10	4.0e-11	2.2e-15	NA	2.0e-12
2	GTEx	Brain Frontal Cortex BA9	0.1998	0.0762	2.9e-03	0.144	NA	0.127	NA	0.152	1.2e-04	NA	3.1e-04	NA	7.8e-05
3	GTEx	Esophagus Mucosa	0.2100	0.0680	3.0e-03	0.002	NA	0.000	NA	-0.002	2.3e-01	NA	3.0e-01	NA	4.7e-01
4	GTEx	Muscle Skeletal	0.0734	0.0253	1.2e-04	0.072	NA	0.055	NA	0.052	1.4e-07	NA	4.5e-06	NA	7.3e-06
5	GTEx	Nerve Tibial	0.1033	0.0420	1.1e-03	0.021	NA	0.013	NA	0.011	1.1e-02	NA	3.9e-02	NA	4.8e-02
6	NTR	Blood	0.0345	0.0098	1.9e-07	0.030	0.025	0.022	0.026	0.028	4.0e-10	9.3e-09	9.7e-08	5.9e-09	2.2e-09
7	ROSMAP	Brain Pre-frontal Cortex	0.1473	0.0395	8.9e-06	0.012	0.032	0.045	0.043	0.032	1.1e-02	5.5e-05	1.6e-06	2.5e-06	4.4e-05
8	TCGA	Breast Invasive Carcinoma	0.0304	0.0167	5.4e-06	0.024	0.028	0.027	NA	0.024	7.0e-06	1.8e-06	2.4e-06	NA	7.9e-06
9	TCGA	Lung Adenocarcinoma	0.0337	0.0239	2.6e-03	0.007	0.016	0.014	NA	0.009	4.9e-02	4.7e-03	7.8e-03	NA	2.4e-02
10	TCGA	Testicular Germ Cell Tumors	0.1020	0.0540	6.9e-05	0.135	0.087	0.084	NA	0.127	1.7e-05	5.6e-04	6.9e-04	NA	3.2e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.3	0.5	2.4	-0.6	0.5	-1.6	-0.1	-0.0	0.2	-1.1	-0.5	0.5	0.4
Bipolar Disorder or Schizophrenia	0.5	1.2	8.0	0.6	0.7	-2.8	-1.1	0.2	0.3	-0.9	-0.7	-0.3	-0.5
Depressed Affect (Nagel 2018)	0.7	1.5	3.4	1.1	0.9	-1.0	-1.0	1.4	1.2	-0.4	-1.4	-1.8	-1.2
Depression (Nagel 2018)	0.2	0.3	1.6	0.1	-0.1	1.3	-0.6	-0.1	-0.3	0.0	-0.2	-0.7	-0.5
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.6	-0.4	0.1	-0.4	0.4	-0.0	-0.1	-0.6	-0.8	0.1	-0.1
Neuroticism (Nagel 2018)	0.2	0.4	0.7	0.3	0.6	-0.8	-0.1	0.6	0.6	-0.7	-0.8	-0.8	-0.5
Schizophrenia (2018)	0.5	1.1	4.8	1.3	0.5	-2.2	-1.4	0.3	0.2	-0.4	-0.5	-0.8	-1.0
Schizophrenia vs Biploar Disorder	0.1	0.1	0.4	0.6	0.5	0.2	-0.3	0.1	0.1	0.5	0.2	-0.2	-0.5
Worry (Nagel 2018)	0.3	0.7	2.4	-1.0	-0.6	-1.5	0.4	-0.4	-0.3	-1.5	-0.4	0.2	0.4
Alzheimer’s Disease (in mother)	1.0	1.1	5.9	-1.7	-1.0	0.5	0.3	-0.1	0.0	-2.4	-0.7	-0.4	0.3
Alzheimer’s Disease (in father)	1.2	1.3	2.4	0.4	0.1	1.5	-1.4	0.8	0.8	-1.1	-1.4	-1.6	-1.5
Alzheimer’s Disease (including proxy)	1.4	2.0	9.2	-1.6	-1.0	1.8	-0.8	0.1	0.2	-3.0	-1.4	-1.0	-0.4
Crohns Disease (2017)	0.4	1.0	3.6	0.7	0.3	-1.9	-1.1	0.8	1.0	-0.3	-0.3	-1.4	-0.9
Irritable Bowel Disease (IBD)	2.3	5.4	10.4	2.7	1.9	0.2	-2.8	2.7	2.9	0.6	-1.3	-3.2	-2.7
Ulcerative Colitis (UC)	3.3	6.2	10.8	3.3	2.2	2.2	-2.5	2.9	2.9	1.5	-1.0	-2.9	-2.5
Major Depression (MDD)	0.2	0.2	0.7	-0.6	0.0	-0.8	-0.0	-0.5	-0.6	-0.2	-0.2	0.4	-0.3
Reaction Time	1.8	3.4	5.7	-2.2	-1.5	-1.3	1.9	-1.8	-1.6	-0.1	2.2	2.2	2.4
Verbal and Numeric Reasoning (VNR)	0.5	1.3	2.9	-1.4	-1.4	-1.1	1.6	-0.7	-0.9	-1.7	-0.4	0.1	0.9
Breast Cancer	0.0	0.1	0.3	0.2	0.1	-0.3	0.1	0.1	0.2	-0.2	0.0	0.5	0.2
Ovarian Cancer	0.1	0.1	0.4	0.3	0.3	-0.3	-0.4	0.0	0.0	0.6	-0.4	0.1	-0.2
Prostate Cancer	0.9	1.3	8.7	1.4	0.9	0.2	0.2	-0.0	0.1	3.0	1.1	0.3	0.1
Age at First Birth	0.9	1.3	3.7	1.1	-0.7	0.4	0.5	-1.0	-1.0	1.9	1.9	1.0	0.7
Bipolar Disorder (2011)	0.3	0.3	0.9	0.5	0.5	-0.7	-1.0	0.3	0.1	0.8	-0.2	-0.1	-0.2
Body Mass Index (BMI) (2010)	1.2	1.6	3.4	0.8	1.5	1.1	-0.9	1.9	1.7	-0.9	-1.3	-1.2	-1.1
Coronary Artery Disease (CAD)	2.2	2.6	7.4	1.1	2.7	-0.4	-1.3	1.9	1.8	0.7	-1.9	-1.5	-1.5
Crohns Disease (2012)	0.3	0.4	0.8	0.6	0.7	-0.9	-0.5	0.5	0.8	0.7	-0.0	-0.9	-0.6
Mean Putamen Volume	0.1	0.1	0.4	0.1	0.1	-0.6	0.6	-0.0	-0.1	-0.5	-0.6	0.1	0.2
Fasting Glucose	0.7	0.8	2.9	0.9	0.9	0.3	-1.3	0.7	0.4	1.7	0.5	-0.6	-0.9
HbA1C	0.1	0.1	0.2	-0.2	0.3	-0.4	0.1	-0.1	-0.2	0.4	0.2	0.2	0.4
HDL Cholesterol	0.8	1.3	2.7	-0.3	-1.1	0.4	1.2	-1.6	-1.6	0.6	1.6	0.9	0.9
LDL Cholesterol	1.4	2.2	4.0	1.7	1.8	0.5	-2.0	1.5	1.5	0.3	-1.5	-1.3	-1.8
Lupus	0.2	0.3	1.2	0.0	0.3	-0.6	-0.3	0.3	0.4	-1.1	-0.7	0.1	-0.2
Neuroticism (2016)	0.1	0.2	0.4	0.6	0.6	0.2	-0.3	0.5	0.3	-0.1	-0.5	-0.4	-0.6
Primary Biliary Cirrhosis	1.4	2.0	3.7	-0.4	-0.8	-0.9	1.4	-1.6	-1.7	1.5	1.6	1.9	1.5
Rheumatoid Arthritis	0.6	0.9	2.9	0.8	-0.7	0.7	0.8	-0.7	-0.7	1.7	1.4	0.7	0.4
Schizophrenia (2014)	0.5	1.2	6.6	1.3	0.6	-2.6	-1.4	0.1	-0.1	-0.6	-0.5	0.0	-0.6
Triglycerides	3.5	5.7	9.1	1.8	2.2	0.1	-3.0	3.0	2.8	-0.9	-3.0	-2.7	-2.6
Type 2 Diabetes (T2D) (2012)	1.1	1.2	3.5	1.9	1.3	1.1	-1.1	0.8	0.6	1.6	-0.2	-0.5	-1.0
Ulcerative Colitis	4.2	6.1	10.2	3.0	2.1	1.4	-2.6	2.9	2.9	0.7	-1.9	-3.2	-2.8
Blood Eosinophil Count	0.5	3.9	6.5	1.4	1.8	0.6	-2.5	2.3	2.2	-0.2	-2.1	-2.4	-2.5
Blood Platelet Count	0.1	1.6	3.0	-0.6	-1.2	-1.7	1.1	-1.4	-1.4	-0.8	0.9	1.5	1.4
Blood Red Count	0.0	0.2	1.2	-0.2	-0.2	1.1	0.3	-0.1	-0.0	-0.2	0.9	0.1	0.2
Blood White Count	0.2	1.2	7.3	-0.4	-1.7	2.7	-0.0	-0.5	-0.7	-0.3	0.6	0.1	-0.3
Heel T-Score	0.2	1.4	9.1	-0.7	-1.4	-3.0	-0.3	-1.0	-1.1	0.1	-0.4	-0.0	-0.1
BMI	0.7	4.0	37.7	-0.1	0.2	6.1	-0.6	0.7	0.7	0.0	0.1	-0.6	-0.6
Height	3.1	59.9	85.9	7.7	9.3	-0.3	-8.6	8.9	8.9	-1.8	-8.6	-7.6	-9.3
Waist Hip Ratio (WHR)	5.3	23.9	40.4	4.0	4.5	-0.6	-6.4	5.4	5.5	-1.6	-5.9	-5.6	-5.9
Systolic Blood Pressure	0.1	0.5	1.9	0.4	-1.4	1.2	0.4	-0.4	-0.1	-0.3	0.5	-0.6	0.1
Smoking Status	0.1	0.2	0.4	-0.5	0.1	-0.3	-0.5	0.4	0.5	-0.6	-0.4	-0.5	-0.6
Allergy or Eczema	0.9	2.3	4.8	0.2	1.2	-0.2	-1.2	2.1	1.9	-1.3	-2.2	-2.0	-1.4
Cardiovascular Disease	0.3	1.1	2.7	1.2	-0.2	1.6	-0.9	0.8	1.1	-1.1	-0.3	-1.3	-1.1
Hypothyroidism (self reported)	0.9	2.0	3.6	-0.5	-1.9	-1.4	1.5	-1.7	-1.8	0.1	1.2	1.9	1.0
Respiratory disease	0.7	1.5	2.7	1.6	1.6	-0.5	-1.6	1.2	0.9	-0.1	-1.2	-1.1	-1.3
Type 2 Diabetes (T2D) (2018)	0.7	1.2	5.8	-0.7	-0.4	2.4	-0.6	0.6	0.3	-1.6	-0.7	-1.2	-0.8
Lung FEV1/FVC ratio	0.9	4.4	17.0	-4.1	-1.0	3.9	0.9	-1.1	-0.7	-2.1	0.5	1.2	1.6
Lung FVC	0.4	2.1	3.6	-0.1	-0.8	-0.9	1.8	-1.6	-1.8	1.5	1.9	1.6	1.4
Neuroticism	0.1	0.3	1.6	0.2	0.4	-1.3	-0.4	0.2	0.3	-0.4	-0.7	-0.6	-0.4
Chronotype (morning person)	1.2	2.7	5.2	1.5	1.0	0.5	-2.3	1.8	1.8	-1.1	-1.6	-1.8	-2.1
Hair Pigment	0.1	2.5	5.7	-2.2	-2.4	-1.2	1.0	-1.8	-1.9	-0.9	0.9	1.1	1.5
Tanning	0.1	1.7	4.4	-2.1	-1.5	-0.7	1.8	-1.2	-1.2	-0.9	0.7	1.0	1.3
Hand grip strength (left)	0.7	1.8	10.1	1.6	1.6	-0.2	0.4	-0.3	-0.3	3.2	0.6	1.5	-0.1
Number of treatments/medications taken	1.3	2.4	4.4	0.5	1.1	1.5	-1.9	1.5	1.5	-2.1	-1.6	-1.8	-1.6
Average weekly spirits intake	1.1	1.3	5.1	-1.9	-1.2	-0.7	1.0	-0.8	-0.5	-2.3	-0.4	-0.1	0.9
Sensitivity / hurt feelings	0.1	0.1	0.4	0.2	0.2	-0.2	0.6	-0.3	-0.2	-0.0	0.0	0.4	0.4
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.2	-1.0	-1.1	0.6	0.5	-1.0	-1.1	-0.1	0.3	0.5	0.6
Hearing difficulty/problems: Yes	2.0	3.1	5.8	1.3	0.6	1.2	-2.0	1.8	1.7	-1.6	-2.3	-2.4	-1.9
Relative age of first facial hair	0.4	0.7	3.4	-0.4	-0.5	-1.9	0.7	-0.2	0.0	-1.6	0.2	0.2	0.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.2	0.2	0.6	1.1	-0.4	0.8	1.0	-0.5	-0.6	-0.4	-0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.6	-0.1	0.4	1.0	-0.2	0.4	0.6	-1.3	-0.5	0.0	0.0
Ever had hysterectomy (womb removed)	3.4	3.9	6.2	1.9	2.0	0.1	-2.5	2.1	2.1	-1.1	-2.4	-2.0	-2.3
Systolic blood pressure, automated reading	0.3	0.8	3.1	-0.8	-1.8	1.5	0.5	-0.7	-0.5	-0.7	0.7	0.1	0.6
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	3.9	1.3	0.7	1.2	-1.8	1.4	1.2	0.3	-1.1	-2.0	-1.6
Angina	0.2	0.3	1.0	-0.7	0.0	1.0	-0.1	0.3	0.2	-1.0	-0.5	-0.3	-0.1
Medication for hormone replacement therapy	0.8	0.9	2.3	0.9	-0.0	0.4	-0.8	1.1	0.9	-1.5	-0.8	-1.2	-0.9
Vitamin and mineral supplements	0.4	0.5	1.7	1.3	0.1	0.8	-0.5	0.5	0.4	1.1	0.2	-0.5	-0.9
Supplements: Zinc	0.1	0.1	1.2	-0.3	0.2	1.1	0.0	0.0	0.1	0.0	-0.3	-0.0	0.0
Medication: Co-codamol	1.6	1.9	6.5	0.7	0.4	2.6	-1.7	1.1	1.0	-1.5	-1.0	-1.2	-1.4
Medication: Metformin	2.0	2.8	12.2	0.4	0.3	3.5	-1.1	1.3	1.0	-1.6	-1.5	-2.1	-1.5
Diabetes (father)	0.1	0.2	0.5	0.2	0.5	-0.5	0.7	0.5	0.5	0.5	0.2	-0.0	0.2
Diabetes (mother)	1.4	1.8	2.9	-1.5	-0.8	-0.3	1.2	-1.5	-1.7	0.8	1.7	1.6	1.4
Severe depression (siblings)	0.4	0.5	2.2	0.3	0.1	1.4	0.4	-0.2	-0.1	1.5	0.3	0.3	0.5
Pack years adult smoking proportion	0.9	1.4	4.6	-2.1	-1.6	0.8	0.8	-1.5	-1.5	-0.4	0.3	0.6	0.8
Impedance of leg (right)	0.6	2.9	6.2	-1.7	-2.4	-2.5	1.3	-1.9	-1.9	0.2	1.8	0.8	1.4
Leg fat-free mass (left)	1.8	9.4	15.4	3.1	3.9	3.4	-3.0	3.4	3.4	0.0	-3.0	-2.4	-3.3
Trunk fat percentage	0.5	1.8	15.4	-0.3	-0.6	3.9	-0.5	0.6	0.6	-0.3	0.5	-0.9	-0.5
Hand grip strength (right)	0.6	1.8	9.2	2.1	1.6	-0.4	0.2	0.2	0.3	3.0	0.5	0.8	-0.5
Townsend deprivation index at recruitment	0.1	0.2	0.6	-0.4	0.0	0.7	0.2	-0.4	-0.3	0.2	0.4	0.7	0.3
Current tobacco smoking	0.1	0.1	0.6	-0.8	-0.3	-0.5	0.0	-0.4	-0.3	0.1	0.1	0.2	-0.1
Average weekly fortified wine intake	0.1	0.1	0.6	0.8	-0.0	0.2	-0.4	0.0	-0.2	-0.3	-0.4	0.2	-0.6
Maternal smoking around birth	0.4	0.6	4.1	-0.4	-0.5	2.0	-0.5	-0.3	-0.3	-0.8	-0.2	0.2	-0.2
Fed-up feelings	0.3	0.5	1.7	1.0	0.1	-0.3	-0.6	0.8	0.6	0.8	-0.3	-1.3	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	3.2	-1.0	-1.8	0.3	0.6	-1.0	-1.3	-0.3	0.5	0.2	0.6
Relative age voice broke	0.4	0.6	3.4	-0.7	-1.0	-0.1	0.8	-0.0	0.2	-1.8	-0.2	-0.6	0.7
Taking other prescription medications	0.3	0.4	1.7	0.2	0.9	1.3	-0.6	0.6	0.5	-0.7	-0.5	0.0	-0.5
Age when periods started (menarche)	0.0	0.1	0.3	0.2	0.1	0.4	-0.4	0.1	0.0	0.4	-0.3	-0.2	-0.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.9	-0.8	-1.3	0.0	0.6	-0.8	-0.9	-1.4	0.5	0.3	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.8	-0.2	-0.4	-1.7	-0.6	-0.1	-0.4	-0.4	-0.7	0.3	-0.7
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.4	-0.8	-0.5	-1.2	0.5	-0.5	-0.5	-0.6	-0.2	0.7	0.4
Qualifications: CSEs or equivalent	0.3	0.4	3.6	0.2	-0.1	-1.9	-0.1	0.2	0.3	-0.1	0.2	-0.3	-0.4
Serious illness, injury or assault to yourself	0.4	0.5	4.1	0.0	0.4	2.0	0.0	0.2	0.3	-0.8	-0.4	-0.0	-0.1
High blood pressure	0.7	2.0	4.1	2.0	0.2	0.7	-1.7	1.2	1.4	-1.4	-0.8	-2.0	-1.8
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.0	-0.2	0.5	-0.3	-0.6	1.2	1.0	-0.4	-1.3	-1.4	-0.7
Multivitamins +/- minerals	0.5	0.6	1.7	-1.3	-0.0	-1.2	0.3	-0.5	-0.5	-0.9	-0.3	0.7	0.8
Stomach or abdominal pain in last month	0.9	1.1	3.5	0.5	0.5	0.6	-1.2	0.9	1.0	-0.9	-1.4	-1.9	-0.8
Supplements: Glucosamine	1.0	1.3	3.9	-1.1	-0.3	-0.1	1.4	-1.1	-1.2	0.9	1.2	2.0	1.2
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	4.2	0.8	0.9	0.1	-1.5	1.6	1.5	-1.4	-2.0	-1.6	-1.6
Medication: Atenolol	0.6	0.7	4.5	-0.3	0.3	2.1	-1.0	0.5	0.6	-0.1	-0.1	-0.8	-0.6
Medication: Levothyroxine sodium	0.6	0.9	4.9	-1.0	-1.5	-0.4	0.5	-0.6	-0.6	-2.2	-0.3	0.4	0.3
Sitting height	0.9	6.5	14.6	2.9	3.8	0.2	-2.1	2.9	2.7	0.2	-2.5	-2.4	-3.1
Chronic bronchitis/emphysema (father)	2.1	2.5	6.3	-1.1	-1.4	0.8	1.6	-1.5	-1.6	0.4	2.5	1.5	2.1
High blood pressure (mother)	1.4	1.9	3.4	-1.2	-1.4	0.8	1.8	-1.6	-1.3	-1.0	1.4	1.5	1.6
Body mass index (BMI)	0.6	2.7	25.2	0.0	0.2	5.0	-0.6	0.7	0.7	-0.2	-0.0	-0.3	-0.5
Impedance of leg (left)	0.4	1.8	5.6	-1.2	-2.0	-2.4	0.7	-1.4	-1.4	-0.2	1.3	0.1	0.8
Leg predicted mass (left)	1.7	9.2	15.1	3.1	3.9	3.4	-3.0	3.3	3.4	0.0	-2.9	-2.4	-3.3
Trunk fat mass	0.9	3.7	19.8	1.1	1.0	4.5	-1.6	1.8	1.7	-0.0	-0.6	-1.7	-1.8
Waist circumference	1.4	5.1	17.8	1.3	1.7	4.2	-2.4	2.3	2.3	-0.6	-1.6	-1.9	-2.3
Number of incorrect matches in round	0.2	0.3	1.8	-0.3	-0.5	0.8	-0.2	-0.0	0.2	-1.4	0.4	-0.0	0.5
Past tobacco smoking	0.4	0.7	1.5	-0.5	-0.6	-0.8	0.7	-1.1	-1.1	0.6	0.8	1.2	0.8
Alcohol usually taken with meals	0.2	0.3	1.1	1.0	0.5	-0.7	0.6	-0.2	-0.3	0.7	0.3	0.6	-0.1
Nervous feelings	1.0	1.8	3.6	-1.9	-1.8	-0.5	1.3	-1.4	-1.3	-1.5	0.4	1.1	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.2	-0.2	-0.3	-0.0	0.0	-0.2	-0.3	0.1	0.4	-0.3	0.4
Hearing difficulty/problems with background noise	2.1	3.3	6.5	2.2	1.0	1.6	-2.1	1.8	1.7	-0.2	-1.6	-2.5	-2.2
Hair/balding pattern: Pattern 2	2.1	2.6	4.6	-2.0	-1.6	-0.6	1.9	-1.8	-1.7	-0.4	1.5	1.6	2.1
Had menopause	1.7	2.1	4.2	-2.1	-1.6	1.4	1.8	-1.5	-1.4	-0.8	1.1	1.0	1.5
Had other major operations	0.7	0.9	5.3	-1.3	-0.4	0.5	-0.4	-0.0	-0.0	-2.3	-1.0	-0.1	0.0
Forced vital capacity (FVC)	0.6	2.5	7.7	2.8	2.6	-0.6	-0.9	0.9	0.8	2.4	-0.5	-0.5	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	2.4	0.7	0.2	-0.7	-1.3	0.8	0.5	0.3	-1.1	-0.7	-1.6
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	2.9	0.8	1.6	0.7	-1.6	1.4	1.1	0.4	-1.7	-1.1	-1.6
Qualifications: None of the above	0.6	1.3	2.7	-0.1	-1.1	1.6	0.4	-1.2	-1.3	0.8	1.6	1.5	0.8
Financial difficulties in last 2 years	1.6	2.1	4.7	1.1	1.2	-0.2	-1.8	1.6	1.4	-0.7	-2.2	-1.7	-1.7
Mouth/teeth dental problems	0.3	0.5	4.5	-0.1	0.1	-2.1	0.1	0.1	-0.2	-0.2	-0.6	-0.1	-0.3
Heart attack	0.2	0.3	0.8	-0.4	0.0	0.9	-0.9	0.3	0.2	-0.6	-0.2	-0.5	-0.4
Allergy	0.3	0.7	1.3	-0.1	-0.7	-0.3	0.7	-1.1	-0.9	1.1	1.0	1.1	0.6
Pain all over the body in last month	0.2	0.2	0.8	0.1	-0.9	0.9	-0.1	-0.2	-0.1	0.1	0.3	-0.7	0.2
Diabetes (self-reported)	1.5	2.3	5.4	0.2	0.2	1.8	-1.5	1.5	1.0	-2.3	-1.7	-1.9	-1.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.8	0.1	0.2	1.3	-0.6	0.5	0.3	-0.2	-0.5	-0.5	-0.1
Medication: Ramipril	0.1	0.1	0.4	0.6	-0.3	0.2	0.2	-0.4	-0.4	0.3	0.6	-0.1	0.0
Medication: Simvastatin	0.4	0.5	1.1	0.5	0.6	0.9	-1.1	0.7	0.7	-0.3	-0.4	-0.9	-0.9
Fluid intelligence score	1.1	2.4	4.5	-1.4	-2.1	-0.7	2.0	-1.8	-1.9	-1.1	1.0	1.0	1.6
Illnesses of siblings	0.7	1.0	5.6	0.9	0.8	-1.5	0.2	0.2	0.0	2.4	0.4	0.2	-0.1
Neuroticism score	0.3	0.7	1.1	-1.0	-1.1	-0.9	0.9	-1.1	-1.1	-0.3	0.4	0.5	0.9
Weight	1.7	8.2	20.8	2.5	3.0	4.6	-2.8	3.0	3.0	-0.1	-2.2	-2.4	-3.1
Impedance of arm (right)	1.3	6.0	11.9	-2.6	-3.4	-3.5	2.6	-2.5	-2.3	-0.2	2.4	0.9	2.4
Arm fat percentage (right)	0.6	2.3	16.3	-1.2	-1.5	4.0	0.6	-0.4	-0.3	-0.0	1.3	0.1	0.6
Trunk fat-free mass	2.7	15.7	29.3	4.6	5.4	2.8	-4.2	4.3	4.2	0.6	-3.9	-2.9	-4.6
Hip circumference	0.5	2.1	18.7	0.2	-0.1	4.3	0.4	-0.2	-0.1	0.5	1.3	0.7	0.2
Time employed in main current job	0.6	0.7	1.1	0.9	1.0	0.9	-0.5	1.0	1.0	0.5	-0.2	-1.0	-0.7
Alcohol intake versus 10 years previously	0.4	0.5	2.8	-0.1	-0.7	1.7	-0.5	-0.4	-0.7	-1.0	-0.1	0.1	-0.2
Father’s age at death	2.6	3.5	8.0	0.1	-0.1	0.7	2.3	-1.7	-1.4	2.6	2.8	2.4	1.9
Worrier / anxious feelings	0.2	0.3	0.5	-0.4	-0.5	0.1	0.6	-0.7	-0.6	-0.6	0.6	0.4	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	2.5	-0.1	-0.4	-0.7	-1.0	0.5	0.6	-1.6	-1.4	-1.2	-0.9
Falls in the last year	0.6	0.8	1.8	0.5	0.6	0.6	-0.9	1.1	1.0	-0.0	-1.1	-1.4	-1.0
Hair/balding pattern: Pattern 3	0.6	0.9	1.5	0.7	0.7	0.8	-1.2	1.0	0.8	-0.6	-1.1	-1.0	-1.2
Number of live births	0.4	0.6	1.7	-0.4	-0.5	-0.3	0.4	-1.1	-1.3	0.2	0.7	1.3	0.5
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	3.8	1.6	1.9	0.8	-0.5	0.6	0.6	1.5	-0.3	-0.1	-0.7
Pulse rate	0.0	0.0	0.1	0.1	-0.3	-0.2	-0.2	0.3	0.3	-0.2	-0.1	-0.2	-0.2
Happiness	0.4	0.4	1.7	-1.1	-0.4	-0.2	-0.8	-0.1	-0.0	-1.3	-0.7	-0.4	-0.2
Noisy workplace	2.8	3.4	7.0	0.5	0.8	1.2	-2.0	2.1	2.1	-0.9	-2.6	-2.6	-2.1
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.1	0.6	1.4	-1.2	-0.0	0.8	0.8	1.3	-0.8	-0.6	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.9	-0.9	-0.4	-0.0	1.0	-0.4	-0.2	0.1	0.3	0.5	0.9
Mouth/teeth dental problems: Dentures	0.7	1.2	5.7	1.3	1.0	2.4	-0.5	0.8	0.9	1.0	0.3	-0.4	-0.6
Asthma	0.5	1.0	1.9	1.4	1.1	0.5	-1.0	1.1	1.0	-0.9	-0.9	-1.1	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	2.9	-0.4	-0.4	1.7	-0.2	0.3	0.4	-1.4	-1.0	-1.2	-0.4
Medication: Cholesterol lowering	2.3	3.6	5.5	1.0	1.8	1.3	-2.4	2.0	1.8	-1.3	-2.1	-2.3	-2.3
Depression (self-reported)	0.2	0.3	0.8	0.2	0.2	-0.6	0.0	-0.5	-0.7	0.9	0.6	0.5	0.3
Medication: Lansoprazole	1.8	2.1	8.5	-2.1	-1.7	0.9	1.1	-0.8	-0.8	-2.9	-0.4	0.4	1.1
Prospective memory result	2.8	3.4	5.8	1.6	1.2	0.3	-2.2	2.2	2.2	-1.6	-2.4	-1.7	-2.1
Lung cancer (father)	0.8	1.0	5.4	1.0	-0.0	2.3	-0.9	0.5	0.4	-1.0	0.1	-0.8	-0.7
Illnesses of mother	2.4	3.0	5.7	2.4	1.8	0.2	-1.9	2.0	1.8	0.9	-1.4	-1.9	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	4.3	1.5	2.1	0.1	-0.4	0.4	0.5	1.6	-0.1	0.3	-0.6
Pulse wave Arterial Stiffness index	1.6	1.9	4.0	-1.4	-2.0	-1.1	1.2	-1.2	-1.2	-1.8	1.0	1.1	1.3
Impedance of arm (left)	1.0	4.8	10.6	-2.2	-3.0	-3.2	2.3	-2.2	-1.9	-0.4	2.1	0.9	2.1
Arm fat mass (right)	0.6	2.3	18.7	0.3	0.4	4.3	-0.7	1.0	1.0	0.0	-0.1	-0.8	-0.8
Trunk predicted mass	2.8	16.2	30.1	4.7	5.5	2.7	-4.2	4.4	4.3	0.6	-4.0	-3.0	-4.6
Standing height	2.3	22.4	36.8	5.5	6.1	-0.6	-5.0	5.2	5.1	0.2	-4.8	-4.7	-5.8
Length of working week for main job	1.2	1.3	2.3	0.2	1.2	-0.5	-1.5	1.2	1.2	-1.5	-1.4	-0.8	-1.1
Exposure to tobacco smoke at home	1.3	1.5	3.2	-1.1	-1.3	0.7	1.1	-1.2	-1.3	0.1	1.8	1.2	1.5
Breastfed as a baby	2.1	2.6	6.3	0.5	0.7	0.2	-1.6	1.7	1.7	-2.1	-2.5	-1.6	-1.9
Tense / ‘highly strung’	0.3	0.5	3.4	-0.5	-0.4	-0.1	-0.3	0.3	0.4	-1.8	-0.7	-0.7	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.9	-0.5	-0.0	-0.2	0.9	-0.5	-0.6	-0.1	0.1	1.0	0.7
Hair/balding pattern: Pattern 4	0.4	1.0	2.5	-1.0	-0.6	-1.3	1.6	-0.8	-0.7	0.1	0.7	1.1	1.3
Birth weight of first child	9.4	17.1	31.9	5.6	4.6	1.1	-4.4	4.4	4.3	1.5	-3.6	-4.3	-5.1
Peak expiratory flow (PEF)	0.6	1.5	3.5	-1.6	-0.4	1.9	1.5	-1.0	-0.8	0.6	1.0	1.4	1.3
Pulse wave reflection index	3.7	4.5	9.7	-3.1	-2.8	-1.2	1.9	-2.1	-2.2	-2.5	0.9	1.4	2.0
Ever highly irritable/argumentative for 2 days	0.8	1.0	4.2	0.8	1.3	1.3	-0.9	0.4	0.4	2.0	-0.2	-0.2	-0.6
Loud music exposure frequency	0.4	0.4	1.4	-0.1	-0.1	1.1	0.4	-0.4	-0.2	1.2	0.7	0.3	0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.4	-0.1	0.9	-1.2	-0.1	0.3	0.4	0.3	-0.6	-0.3	0.0
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	1.0	0.4	-0.1	0.6	-0.3	-0.2	-0.1	1.0	0.5	0.2	0.1
Blood clot in the leg (DVT)	0.4	0.5	1.6	0.8	0.9	-0.3	-1.0	0.4	0.3	1.3	-0.2	-0.4	-0.7
Medication: Paracetamol	1.9	3.2	6.5	1.2	0.6	1.9	-2.3	1.7	1.7	-1.3	-1.7	-2.6	-2.1
Headache pain in last month	0.4	0.6	2.8	-1.4	-0.4	-0.2	0.5	0.2	0.3	-1.7	-0.6	-0.4	0.5
Medication for cholesterol, blood pressure or diabetes	1.8	3.1	5.4	-1.8	-1.6	-1.9	2.3	-1.8	-1.8	0.5	0.9	2.0	2.1
Glaucoma (self-reported)	0.4	0.5	1.1	-0.8	-0.7	-0.3	0.4	-0.7	-0.7	-1.0	0.2	1.1	0.8
Gout (self-reported)	0.2	0.2	0.4	-0.1	0.1	-0.5	-0.4	0.6	0.4	-0.5	-0.5	-0.6	-0.7
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.7	0.6	-0.4	-0.8	-0.4	0.1	0.0	-0.6	-0.4	0.3	-0.6
Medication: Amlodipine	0.5	0.7	2.1	1.5	0.8	0.9	-0.6	0.2	0.4	1.3	0.5	-0.4	-0.5
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.8	0.7	0.1	0.0	1.1	-1.0	-1.1	2.0	1.4	1.5	0.9
Birth weight	19.5	42.4	62.3	6.7	7.8	-0.8	-7.4	7.5	7.2	-0.3	-7.7	-5.8	-7.9
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.7	-0.7	-0.6	0.3	0.4	-1.0	-1.1	0.0	0.4	1.3	0.5
High blood pressure (siblings)	1.0	1.4	2.4	-0.3	-1.2	1.6	0.7	-1.5	-1.5	-0.4	1.3	1.5	0.9
Forced vital capacity (FVC), Best measure	0.6	2.3	7.4	2.7	2.3	-1.5	-0.9	0.7	0.6	2.2	-0.4	-0.2	-1.2
Body fat percentage	0.6	2.2	19.7	-0.5	-0.9	4.4	-0.2	0.3	0.3	-0.2	0.7	-0.6	-0.2
Leg fat percentage (right)	0.8	2.8	21.4	-1.0	-1.4	4.6	0.4	-0.6	-0.6	0.1	1.5	0.6	0.6
Arm fat-free mass (right)	3.0	15.6	26.7	4.3	5.2	3.9	-4.2	4.2	4.2	0.3	-3.7	-3.0	-4.5
Exposure to tobacco smoke outside home	0.9	1.2	3.2	-1.0	-1.1	0.0	1.8	-1.0	-0.8	-0.2	1.3	1.0	1.7
Comparative body size at age 10	0.3	0.8	2.3	1.5	1.4	0.2	-0.9	0.6	0.7	1.2	-0.6	0.3	-0.7
Number of full brothers	1.0	1.2	3.1	0.6	-0.0	1.8	-1.4	0.8	0.7	-1.7	-0.8	-1.1	-1.0
Worry too long after embarrassment	1.5	2.5	4.5	-2.1	-1.1	-1.2	2.0	-1.9	-1.9	-0.8	0.3	1.8	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.4	-0.7	-0.4	1.0	0.6	-0.2	-0.1	-1.2	-0.3	0.2	0.5
Wheeze or whistling in the chest in last year	0.1	0.2	0.6	-0.2	-0.6	0.4	0.5	-0.5	-0.6	-0.8	0.1	0.2	0.4
Number of children fathered	3.0	3.3	5.4	2.3	1.2	-0.3	-2.1	2.2	2.0	-0.7	-1.9	-2.1	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.5	0.0	0.7	-0.3	-0.2	0.5	0.5	0.1	-0.6	-0.3	-0.1
Age at first live birth	0.2	0.3	1.2	0.2	-0.5	0.1	0.7	-0.2	-0.2	0.8	1.1	0.1	0.1
Pulse wave peak to peak time	2.2	2.6	5.5	1.8	2.3	1.0	-1.6	1.5	1.5	1.8	-1.2	-1.3	-1.6
Health satisfaction	1.8	2.3	4.4	1.2	1.3	-0.2	-2.1	1.6	1.7	-1.1	-1.7	-1.7	-1.7
Shortness of breath walking on level ground	2.2	2.7	7.0	2.6	1.2	2.4	-1.6	1.5	1.4	1.1	-0.6	-1.1	-1.7
Qualifications: College or University degree	0.2	0.6	2.7	1.0	1.0	-1.6	-0.2	0.4	0.3	0.7	-0.2	-0.1	-0.4
Eye problems/disorders: None of the above	0.8	0.9	1.4	-0.8	-1.2	-0.8	1.2	-0.9	-0.9	-0.7	1.0	0.9	1.1
Mouth/teeth dental problems: Loose teeth	0.0	0.1	0.2	-0.3	0.2	-0.2	0.0	0.1	0.2	0.2	-0.0	-0.3	0.4
Emphysema/chronic bronchitis	0.5	0.6	2.1	0.5	0.4	-0.6	-0.9	0.5	0.3	-1.4	-0.9	-0.5	-0.6
Medication for pain relief, constipation, heartburn	4.0	6.9	12.5	-1.8	-1.0	-2.6	2.9	-2.7	-2.7	2.3	2.8	3.5	3.0
Neck or shoulder pain in last month	0.9	1.3	2.4	-0.2	0.3	1.5	-1.2	0.9	1.1	-1.5	-1.3	-1.5	-1.2
Medication: Blood pressure	2.2	4.0	9.8	3.1	2.2	1.6	-2.3	1.9	1.9	1.3	-0.2	-1.8	-2.2
Angina (self-reported)	0.4	0.5	1.8	-0.5	0.1	1.3	-0.3	0.5	0.4	-1.0	-0.7	-0.6	-0.4
Migraine (self-reported)	0.6	0.7	2.3	0.8	-0.2	1.5	-0.6	0.7	0.7	-1.0	-0.4	-1.2	-0.7
Medication: Ibuprofen	0.4	0.5	3.8	-0.2	-0.7	2.0	0.4	-0.4	-0.2	-0.6	0.3	-0.3	0.2
Medication: Allopurinol	0.3	0.4	1.1	-0.3	-0.2	0.4	-0.6	0.6	0.5	-1.0	-0.5	-1.0	-0.7
Medication: Omeprazole	3.4	4.1	12.6	1.6	1.4	3.6	-2.3	1.9	1.8	0.1	-1.4	-2.2	-2.1
Medication: Seretide 50 evohaler	0.3	0.3	1.1	0.6	0.1	0.2	0.2	-0.7	-0.7	0.7	0.4	1.1	-0.0
Mean time to correctly identify matches	0.5	0.9	2.2	-1.5	-0.9	-1.0	0.8	-0.6	-0.4	-0.8	0.9	1.1	1.2
Heart disease (mother)	2.4	3.0	9.1	-3.0	-1.8	-0.5	0.9	-1.8	-1.8	-2.4	0.1	1.6	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.7	-0.8	-0.9	-0.2	1.0	-1.2	-1.0	-0.5	0.8	1.3	1.1
Whole body fat mass	0.8	3.4	22.1	0.9	0.8	4.7	-1.3	1.5	1.4	0.1	-0.4	-1.4	-1.4
Leg fat mass (right)	0.8	3.3	24.1	0.7	0.7	4.9	-1.2	1.3	1.2	0.1	-0.4	-1.0	-1.3
Arm predicted mass (right)	3.0	15.5	26.8	4.3	5.2	3.7	-4.1	4.3	4.2	0.4	-3.8	-3.0	-4.4
Pulse rate, automated reading	2.0	6.4	13.0	-1.8	-3.6	-0.3	2.9	-2.9	-2.8	0.9	3.4	2.1	2.7
Alcohol intake frequency.	0.5	1.2	4.0	-0.6	-0.9	2.0	0.3	-0.9	-1.1	0.1	1.4	1.1	1.0
Comparative height size at age 10	3.7	20.2	30.2	4.9	5.2	0.1	-5.3	5.0	4.9	0.2	-4.6	-4.6	-5.5
Number of full sisters	2.0	2.4	3.8	0.9	1.8	0.2	-1.9	1.7	1.6	-1.2	-1.9	-1.5	-1.8
Suffer from ‘nerves’	1.6	2.6	4.6	-2.0	-1.0	-1.6	1.9	-1.6	-1.5	0.0	1.2	2.1	2.0
Overall health rating	1.1	2.4	9.5	0.3	-0.3	3.1	-1.5	1.0	1.2	-1.8	-1.2	-1.9	-1.2
Chest pain or discomfort	0.9	1.3	2.7	-1.6	-1.0	0.1	1.1	-1.2	-1.1	-1.6	0.2	1.1	1.3
Had major operations	2.3	2.7	4.7	0.1	1.5	2.2	-1.5	1.5	1.6	-1.6	-2.1	-1.6	-1.8
Age at last live birth	0.5	0.8	2.4	0.6	-0.5	-1.4	0.9	-0.3	-0.2	1.2	1.5	0.1	0.6
Family relationship satisfaction	0.5	0.6	2.4	-1.6	-0.7	-0.7	0.2	-0.6	-0.5	-0.9	-0.5	0.6	0.6
Leg pain on walking	1.3	1.6	3.5	1.2	1.2	1.9	-1.4	1.2	1.3	1.3	-0.9	-1.0	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.5	-0.7	-0.3	0.1	0.3	-0.3	-0.3	-0.2	0.4	0.3	0.6
Commuting to job workplace: Car/motor vehicle	1.5	1.7	5.4	0.9	0.2	-1.3	0.7	-1.0	-1.1	2.3	1.7	1.5	1.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.4	0.6	-0.1	-1.2	0.3	-0.4	-0.4	0.9	1.0	0.6	0.1
Medication: Aspirin	1.8	2.4	3.6	1.5	1.4	-0.2	-1.7	1.6	1.6	-1.2	-1.8	-1.8	-1.9
Supplements: Vitamin C	0.1	0.2	0.6	-0.3	0.4	-0.8	0.4	0.0	0.0	-0.2	-0.3	0.5	0.5
Knee pain experienced in last month	0.3	0.4	0.8	0.5	-0.0	0.2	-0.9	0.5	0.5	-0.8	-0.8	-0.9	-0.8
Hypertension (Self-reported)	0.3	0.8	2.0	1.4	-0.1	0.7	-0.9	0.6	0.7	-1.2	-0.1	-1.2	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	2.5	0.8	0.1	1.6	-0.6	0.1	0.2	0.1	0.0	-0.3	-0.2
Illnesses of father: Heart disease	2.5	3.4	6.6	-2.0	-2.0	-2.6	1.2	-2.0	-1.9	-2.5	0.2	1.6	1.3
Illnesses of siblings: Diabetes	0.4	0.5	1.4	-0.2	0.5	1.2	-0.4	0.7	0.7	-1.1	-0.5	-0.7	-0.3
Smoking status: Previous	0.3	0.4	1.6	0.2	-0.1	0.6	-0.2	0.7	0.7	-1.3	-0.5	-0.8	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	6.5	1.9	2.5	0.5	-0.9	1.7	1.9	0.3	-1.4	-1.5	-1.7
Whole body fat-free mass	2.5	14.5	25.6	4.1	5.1	3.2	-3.9	4.2	4.1	0.2	-3.8	-2.9	-4.3
Leg fat-free mass (right)	1.9	10.1	16.9	3.2	4.1	3.1	-3.1	3.6	3.6	-0.1	-3.2	-2.6	-3.5
Arm fat percentage (left)	0.5	2.2	17.7	-0.9	-1.2	4.2	0.4	-0.2	-0.1	-0.1	1.1	-0.0	0.4
Average weekly red wine intake	0.5	0.8	2.2	0.0	0.3	-1.2	-0.4	0.7	0.9	-1.5	-1.3	-0.9	-0.7
Handedness (chirality/laterality): Left-handed	4.4	5.3	9.2	-1.4	-1.7	-0.0	2.6	-2.7	-2.7	1.8	3.0	2.8	2.5
Mood swings	0.2	0.3	0.9	-0.2	-1.0	0.4	0.5	-0.6	-0.6	0.4	0.7	-0.2	0.7
Loneliness, isolation	2.0	2.7	5.1	0.8	1.0	-2.0	-2.0	1.4	1.2	-1.0	-2.2	-2.1	-1.9
Long-standing illness, disability or infirmity	0.8	1.3	3.7	0.5	1.3	1.9	-0.8	1.4	1.6	-0.7	-0.7	-0.5	-0.7
Ever had bowel cancer screening	0.4	0.5	2.0	-0.8	-0.5	1.4	-0.1	-0.2	-0.2	-1.2	0.1	0.4	0.6
Diabetes diagnosed by doctor	1.2	2.0	5.1	0.4	0.3	2.2	-1.5	1.2	0.8	-1.6	-1.4	-1.8	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	5.3	0.7	0.6	-1.6	0.5	-0.3	-0.3	2.3	1.0	0.8	0.8
Friendships satisfaction	0.2	0.3	1.2	-0.2	0.3	0.8	-0.3	-0.1	0.2	1.1	0.7	0.3	0.2
Qualifications: nursing, teaching	0.5	0.7	2.7	-1.0	-0.9	-1.4	0.8	-0.2	-0.1	-1.6	-0.5	-0.3	0.3
Commuting to job workplace: Walk	0.5	0.5	2.9	-0.9	-1.0	0.2	-0.2	0.1	0.1	-1.7	-0.5	-0.5	-0.2
Eye problems/disorders: Cataract	1.1	1.2	5.8	0.9	0.6	2.4	-0.9	0.7	0.7	1.5	-0.2	-0.8	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.0	-0.1	-0.4	0.3	-0.5	0.4	0.4	-1.0	-0.7	-0.7	-0.4
Medication for cholesterol	0.3	0.5	2.3	-0.0	1.3	0.2	-0.5	0.3	0.2	1.5	-0.3	0.1	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	8.0	9.4	13.2	3.4	3.2	1.2	-3.5	3.6	3.6	0.9	-2.8	-3.4	-3.6
Back pain experienced in last month	0.1	0.2	0.9	-0.1	-0.2	0.9	-0.3	-0.1	-0.0	-0.7	0.3	-0.0	0.1
Mineral and other dietary supplements	0.5	0.7	1.6	1.1	0.3	0.8	-0.9	0.7	0.7	-0.2	-0.5	-1.3	-1.1
Breast cancer (self-reported)	4.3	5.1	9.8	-2.4	-2.1	0.2	2.1	-3.0	-3.1	0.2	1.8	3.0	2.4
Asthma (self-reported)	0.7	1.3	2.0	1.4	1.3	0.5	-1.1	1.3	1.1	-1.0	-1.1	-1.2	-1.1
Osteoporosis (self-reported)	0.6	0.8	2.9	0.2	1.7	1.7	-0.1	0.8	0.9	-0.1	-0.6	-0.1	-0.2
Osteoarthritis (self-reported)	0.4	0.5	1.5	-0.1	-0.0	0.2	-0.8	0.7	0.8	-1.2	-0.9	-0.4	-0.6
Medication: Aspirin	2.4	3.2	4.7	1.5	1.4	0.4	-1.9	1.9	1.9	-1.6	-2.0	-2.2	-2.2
Medication: Gliclazide	1.0	1.1	2.9	0.4	0.7	1.5	-0.6	1.1	1.0	-1.2	-1.7	-0.9	-0.9
Illnesses of father: None of the above (group 1)	1.2	1.5	2.7	0.9	1.3	1.6	-1.2	1.4	1.5	0.6	-0.9	-1.2	-1.3
Smoking status: Current	0.1	0.2	0.6	-0.1	0.4	-0.0	-0.7	0.3	0.4	0.2	-0.4	-0.5	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	1.3	-0.0	0.6	1.1	0.2	0.2	0.3	0.2	-0.2	-0.3	0.0
Whole body water mass	2.5	14.2	25.4	4.1	5.0	3.1	-3.9	4.2	4.1	0.2	-3.7	-2.9	-4.3
Leg predicted mass (right)	1.9	10.1	16.8	3.3	4.1	3.1	-3.1	3.5	3.5	-0.1	-3.2	-2.6	-3.5
Arm fat mass (left)	0.6	2.6	18.0	0.6	0.7	4.2	-1.0	1.3	1.3	-0.0	-0.5	-1.0	-1.1
Number of self-reported non-cancer illnesses	1.3	2.3	6.0	1.1	1.4	2.4	-1.8	1.6	1.7	-1.4	-1.2	-0.9	-1.3
Average weekly champagne plus white wine intake	1.0	1.4	7.9	1.5	1.6	-0.8	-0.2	0.1	0.0	2.8	0.9	0.4	0.0
Miserableness	2.2	3.8	7.8	-1.7	-1.6	-1.0	2.8	-2.1	-2.1	0.4	2.0	2.2	2.5
Guilty feelings	0.8	1.2	3.0	0.5	0.1	-1.0	0.7	-1.1	-1.3	1.7	1.2	1.5	0.9
Wears glasses or contact lenses	0.1	0.2	0.4	0.2	-0.2	-0.7	0.4	0.3	0.4	-0.3	0.5	-0.4	0.3
Ever taken oral contraceptive pill	0.5	0.6	2.4	-0.5	-0.0	-1.6	1.1	-0.7	-0.5	-0.4	0.4	0.8	0.8
Hearing aid user	0.6	0.7	2.5	-1.3	-1.1	0.7	0.3	-0.1	0.0	-1.6	-0.1	-0.7	0.4
Mother’s age at death	1.6	2.1	3.4	-1.6	-1.5	-0.1	1.6	-1.7	-1.8	-0.8	1.2	1.6	1.6
Financial situation satisfaction	0.6	0.7	2.2	0.0	0.0	-0.6	-1.1	0.4	0.4	-1.5	-1.4	-0.4	-0.9
Tinnitus: Yes, now most or all of the time	0.7	0.8	3.1	0.9	0.5	1.8	-1.2	0.6	0.5	0.3	-0.4	-1.0	-1.1
Commuting to job workplace: Public transport	1.7	2.0	7.3	0.2	0.2	0.4	-0.9	1.5	1.7	-1.3	-1.8	-2.7	-1.4
Eye problems/disorders: Glaucoma	0.1	0.1	0.5	0.2	0.3	0.4	-0.3	-0.0	-0.0	-0.7	-0.2	0.5	-0.0
Medication: Blood pressure	1.1	2.0	4.8	-1.5	-2.2	-0.9	1.5	-1.6	-1.4	-1.3	0.9	0.9	1.4
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.5	-0.5	0.2	0.2	-0.7	0.3	0.2	-0.6	-0.4	-0.2	-0.2
Supplements: Fish oil (including cod liver oil)	1.1	1.5	6.2	-1.1	-0.6	-2.5	1.0	-0.9	-1.0	0.4	0.9	1.3	1.3
High cholesterol (Self-reported)	0.5	0.8	1.8	0.7	0.6	0.9	-1.4	0.9	0.9	-0.6	-0.9	-1.1	-1.0
Medication: Bendroflumethiazide	0.2	0.3	1.4	1.2	-0.0	-0.1	-0.7	0.1	0.1	0.5	0.3	-0.2	-0.7
Medication: Paracetamol	0.8	1.2	3.1	0.5	-0.1	1.8	-1.4	0.6	0.6	-1.2	-0.9	-1.5	-1.1
Medication: Lisinopril	0.2	0.2	0.6	0.0	-0.1	-0.5	0.7	-0.1	0.0	0.4	0.5	0.8	0.5
Medication: Atorvastatin	0.7	0.8	5.5	-0.1	0.8	2.4	-0.3	0.6	0.8	-0.5	-0.6	-0.5	-0.2
Illnesses of father: High blood pressure	0.9	1.1	1.6	-0.6	-0.7	-1.1	1.2	-1.1	-1.0	0.7	1.2	1.2	1.2
Alcohol drinker status: Never	0.4	0.5	2.0	0.1	-0.1	-0.5	0.1	-0.6	-1.0	1.4	0.8	0.7	0.3
Ever smoked	0.3	0.5	1.2	0.7	0.7	0.7	-0.5	1.0	1.1	0.1	-0.4	-0.9	-0.7
Basal metabolic rate	2.2	12.3	20.2	3.7	4.5	3.6	-3.6	3.8	3.8	0.2	-3.3	-2.7	-3.9
Leg fat percentage (left)	0.7	2.6	22.7	-0.6	-1.1	4.8	0.0	-0.2	-0.3	-0.1	1.1	0.2	0.2
Arm fat-free mass (left)	2.5	12.6	20.5	3.8	4.5	3.8	-3.8	3.8	3.7	0.2	-3.4	-2.6	-4.0
Number of operations (self-reported)	2.5	3.7	10.0	-0.2	1.0	1.9	-2.1	1.6	1.4	-3.2	-2.7	-1.6	-1.8
Average weekly beer plus cider intake	0.1	0.1	0.4	0.3	-0.6	-0.0	-0.5	-0.2	-0.4	-0.2	0.3	-0.4	-0.4
Irritability	0.6	1.0	1.7	-1.1	-1.3	0.9	1.1	-1.1	-1.0	0.1	1.3	0.2	1.1
Risk taking	3.0	4.4	8.5	2.6	2.9	-0.2	-2.0	2.4	2.5	0.5	-1.8	-2.0	-2.1
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.5	-0.2	0.1	0.3	-0.0	-0.1	-0.3	-0.0	0.1	0.1
Fractured/broken bones in last 5 years	0.5	0.6	1.3	-0.6	-0.4	1.2	1.1	-0.6	-0.7	0.6	0.7	0.6	1.0
Age started oral contraceptive pill	0.7	0.8	3.4	-0.7	-0.8	-1.8	0.5	-0.3	-0.2	-1.6	-0.9	0.0	0.4
Diastolic blood pressure, automated reading	0.5	1.6	5.1	-1.1	-0.3	2.2	-0.8	0.8	1.2	-2.0	-1.2	-1.1	-0.6
Ever depressed for a whole week	0.3	0.4	0.9	-0.7	-0.9	-1.0	-0.1	-0.5	-0.7	-0.8	-0.3	0.2	0.1
Unable to work because of sickness or disability	0.5	0.7	2.6	-1.1	-1.0	1.6	-0.0	-0.4	-0.3	-1.1	-0.0	-0.2	0.3
Commuting to job workplace: Cycle	0.6	0.8	3.2	0.6	0.7	-1.2	0.8	-0.1	-0.1	1.8	0.9	0.9	0.3
Myopia	3.6	5.2	9.1	-3.0	-3.0	-0.5	2.4	-2.0	-2.0	-3.0	1.2	1.8	2.4
Vascular/heart problems diagnosed by doctor	0.4	1.2	3.1	-1.2	0.1	-0.8	1.1	-0.9	-1.1	1.7	0.5	1.4	1.1
Cholesterol lowering medication	0.4	0.6	2.3	-0.4	-0.7	1.5	0.4	-0.7	-0.6	-0.2	0.8	0.9	0.8
Medication: Omeprazole (e.g. Zanprol)	1.9	2.4	7.1	1.2	1.2	2.7	-1.6	1.5	1.5	-0.6	-1.2	-1.7	-1.4
Pain experienced in last month	1.3	2.1	6.2	-0.1	0.1	-1.6	1.3	-1.4	-1.6	1.8	1.4	2.5	1.2
Supplements: Calcium	0.3	0.3	1.3	-0.2	0.1	1.1	-0.1	0.3	0.5	-1.0	0.1	0.1	0.4
Basal cell carcinoma (self-reported)	1.4	1.7	3.6	-1.5	-0.3	-1.0	1.9	-1.1	-1.0	-1.4	-0.0	1.9	1.4
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.7	-0.5	0.0	0.5	-0.8	0.1	0.0	-0.5	-0.2	-0.4	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.6	1.0	1.0	-0.5	-1.0	0.5	0.4	1.3	-0.2	-0.4	-0.7
Heart disease (siblings)	1.5	1.9	12.9	-1.3	-0.6	-1.0	-0.7	-0.1	-0.1	-3.6	-1.4	-0.4	-0.4
Alcohol drinker status: Previous	0.6	0.7	3.3	-0.2	-0.4	1.5	-0.4	0.3	0.4	-1.8	-0.3	-0.6	0.1
Pack years of smoking	0.9	1.3	4.4	-2.1	-1.6	0.7	0.7	-1.4	-1.4	-0.6	0.1	0.5	0.7
Impedance of whole body	0.6	3.1	8.8	-1.6	-2.5	-3.0	1.4	-1.7	-1.7	-0.1	1.8	0.4	1.3
Leg fat mass (left)	0.9	3.7	25.2	1.0	0.9	5.0	-1.4	1.5	1.4	0.1	-0.5	-1.2	-1.5
Arm predicted mass (left)	2.9	15.0	23.8	4.2	4.9	3.7	-4.2	4.2	4.1	0.3	-3.8	-3.0	-4.4