Hub : Genes

IAH1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0750	0.0260	7.8e-05	0.032	0.025	0.020	0.025	0.021	8.5e-05	4.8e-04	1.6e-03	3.9e-04	1.2e-03
2	GTEx	Cells Transformed fibroblasts	0.0910	0.0390	1.7e-03	0.095	NA	0.070	NA	0.073	1.4e-07	NA	5.7e-06	NA	3.7e-06
3	GTEx	Esophagus Mucosa	0.1230	0.0470	3.3e-03	0.004	NA	-0.002	NA	0.007	1.6e-01	NA	5.0e-01	NA	1.1e-01
4	GTEx	Pancreas	0.2200	0.0750	3.2e-04	0.135	NA	0.089	NA	0.131	2.6e-06	NA	1.4e-04	NA	3.8e-06
5	GTEx	Testis	0.3000	0.0840	4.6e-05	0.074	NA	0.076	NA	0.094	3.4e-04	NA	2.9e-04	NA	5.8e-05
6	NTR	Blood	0.0306	0.0084	2.0e-08	0.034	0.027	0.033	0.034	0.036	2.8e-11	2.7e-09	7.1e-11	3.6e-11	8.8e-12
7	ROSMAP	Brain Pre-frontal Cortex	0.0793	0.0226	2.0e-07	0.070	0.059	0.063	0.061	0.065	2.2e-09	4.1e-08	1.7e-08	2.3e-08	8.8e-09
8	YFS	Blood	0.0662	0.0177	6.8e-09	0.010	0.025	0.039	0.023	0.025	2.2e-04	7.3e-09	9.2e-13	3.8e-08	7.4e-09
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0257	0.0192	3.3e-03	0.015	0.021	0.017	NA	0.017	7.2e-03	1.7e-03	4.5e-03	NA	4.5e-03
10	TCGA	Thyroid Carcinoma	0.0910	0.0510	4.4e-03	0.031	0.030	0.028	NA	0.027	5.0e-04	5.4e-04	8.6e-04	NA	1.0e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.5	0.8	2.2	-1.4	-0.2	0.7	-0.6	-0.2	0.3	-0.6	-1.5	-0.7	-1.4
Bipolar Disorder or Schizophrenia	0.2	0.6	2.0	-1.4	-0.2	0.7	-0.5	-0.3	0.3	-0.7	-1.0	-0.7	-1.1
Depressed Affect (Nagel 2018)	0.8	1.6	3.2	-0.7	-1.4	-1.6	0.3	-1.4	1.3	-1.4	-1.8	-1.1	0.8
Depression (Nagel 2018)	0.1	0.1	0.4	0.6	0.1	-0.2	0.0	0.1	-0.1	0.6	-0.3	0.2	0.5
Intelligence (Savage-Jansen 2018)	0.4	1.1	5.0	0.2	0.1	-2.2	-1.1	0.0	0.1	0.5	-1.4	-0.5	-1.4
Neuroticism (Nagel 2018)	0.3	0.6	2.0	-0.3	-0.6	-1.3	-0.1	-0.7	0.7	-0.8	-1.4	-0.7	-0.0
Schizophrenia (2018)	0.1	0.1	0.5	-0.7	-0.1	0.4	-0.1	-0.3	0.1	-0.4	-0.2	-0.4	-0.2
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	0.0	-0.1	0.3	0.4	0.1	0.1	0.4	0.5	-0.1	0.2
Worry (Nagel 2018)	0.3	0.6	1.7	-0.2	0.4	-1.2	-1.3	0.3	-0.4	-0.2	-1.1	0.2	-0.9
Alzheimer’s Disease (in mother)	0.5	0.6	3.1	-0.5	0.2	-1.4	-1.8	-0.0	-0.3	0.4	0.4	0.2	-0.4
Alzheimer’s Disease (in father)	0.4	0.5	1.7	-0.4	-0.6	-1.3	-0.2	-0.7	0.6	-0.5	-0.5	-0.5	0.9
Alzheimer’s Disease (including proxy)	0.5	0.7	4.0	-0.1	0.0	-1.5	-2.0	-0.2	-0.2	0.4	0.3	0.2	0.0
Crohns Disease (2017)	0.4	0.8	2.3	-0.7	-0.8	-0.3	1.3	-0.4	0.7	-1.0	1.0	-0.3	1.5
Irritable Bowel Disease (IBD)	2.6	6.1	12.9	-2.2	-2.8	-0.1	3.4	-2.3	2.6	-3.1	0.1	-1.7	3.6
Ulcerative Colitis (UC)	3.9	7.3	15.9	-2.4	-2.9	0.2	3.9	-2.4	2.8	-3.3	-0.3	-1.8	4.0
Major Depression (MDD)	1.0	1.2	3.2	1.8	0.6	1.6	-1.5	0.5	-0.4	0.9	1.0	-0.0	-1.3
Reaction Time	0.9	1.8	3.8	0.1	1.6	2.0	0.4	1.8	-1.6	1.0	1.0	1.8	-0.4
Verbal and Numeric Reasoning (VNR)	1.1	2.7	14.5	0.8	0.8	-3.8	-2.1	0.4	-1.0	1.0	-1.7	0.5	-1.4
Breast Cancer	0.1	0.2	0.9	0.3	-0.2	0.8	-0.7	-0.3	-0.0	0.2	-0.1	-0.3	-0.9
Ovarian Cancer	0.4	0.5	1.9	0.0	-0.0	1.4	-1.0	0.2	0.0	0.4	0.5	-0.4	-1.1
Prostate Cancer	1.0	1.4	6.2	0.8	-0.1	1.4	2.5	0.2	0.2	-0.2	1.7	0.2	1.4
Age at First Birth	1.7	2.5	7.3	2.0	1.1	1.4	1.5	1.3	-1.0	0.8	2.7	1.6	1.7
Bipolar Disorder (2011)	0.3	0.3	1.0	-0.4	-0.3	-0.0	0.2	-0.5	0.3	-0.9	-1.0	-0.5	-0.4
Body Mass Index (BMI) (2010)	3.1	4.3	11.1	-3.3	-2.0	-2.3	0.7	-2.0	1.7	-2.0	-2.8	-1.8	0.2
Coronary Artery Disease (CAD)	2.6	3.2	7.9	-1.2	-2.2	1.2	-0.1	-2.2	2.3	-1.4	-1.4	-2.8	-1.4
Crohns Disease (2012)	0.3	0.4	1.4	-0.7	-0.5	-0.1	1.2	-0.3	0.5	-0.4	0.8	-0.4	0.8
Mean Putamen Volume	0.8	1.0	3.8	-1.2	0.0	-2.0	-0.7	-0.2	0.1	-0.1	-1.5	-0.4	-1.2
Fasting Glucose	0.8	1.0	4.0	-0.2	-0.5	0.8	2.0	-0.5	0.6	-0.3	0.5	-0.1	2.0
HbA1C	0.7	0.8	3.7	-1.9	0.0	-1.2	-0.3	0.0	-0.1	-0.1	-1.4	-0.2	-0.7
HDL Cholesterol	1.0	1.6	3.0	1.4	1.6	0.2	0.6	1.7	-1.6	1.6	0.5	1.6	0.7
LDL Cholesterol	1.0	1.6	2.8	-1.4	-1.5	0.5	0.5	-1.5	1.7	-1.7	-0.4	-1.6	0.3
Lupus	0.3	0.5	1.7	-0.7	-0.2	-0.6	-1.0	-0.5	0.1	-0.4	-1.3	-0.4	-1.0
Neuroticism (2016)	0.3	0.5	1.5	-0.7	-0.5	-1.2	0.2	-0.6	0.4	-0.5	-1.1	-0.6	0.1
Primary Biliary Cirrhosis	0.9	1.3	2.7	1.0	1.5	0.9	-0.4	1.6	-1.3	1.2	0.7	1.2	-0.9
Rheumatoid Arthritis	2.2	3.1	8.5	2.0	0.7	2.1	2.0	1.2	-0.8	0.9	2.9	1.4	2.1
Schizophrenia (2014)	0.2	0.4	1.3	-0.9	-0.0	0.7	-0.7	-0.1	0.1	-0.2	-0.9	-0.5	-1.1
Triglycerides	3.4	5.6	9.5	-2.5	-2.9	-1.1	0.2	-3.1	2.8	-3.0	-2.4	-2.8	0.1
Type 2 Diabetes (T2D) (2012)	1.3	1.5	2.9	-1.5	-1.0	-1.6	1.6	-0.7	0.9	-0.7	-1.7	-0.7	1.1
Ulcerative Colitis	4.0	5.8	9.3	-2.7	-2.9	0.1	2.3	-2.5	2.8	-3.0	-0.7	-2.2	2.9
Blood Eosinophil Count	0.4	2.7	5.2	-1.1	-2.3	0.9	0.8	-2.3	2.1	-2.2	-0.3	-2.0	0.9
Blood Platelet Count	0.1	1.7	3.5	0.7	1.4	0.7	-1.7	1.2	-1.4	1.1	1.4	1.0	-1.9
Blood Red Count	0.1	0.5	1.6	0.3	0.1	-0.8	1.1	0.2	-0.1	0.5	-0.8	0.5	1.3
Blood White Count	0.2	1.5	4.7	1.2	0.7	-0.2	0.0	0.8	-1.0	1.0	2.2	1.5	1.7
Heel T-Score	0.2	1.3	3.4	1.9	1.2	0.5	-1.6	0.8	-0.7	1.2	1.2	1.0	-0.2
BMI	0.2	1.0	4.1	-1.0	-0.7	-1.1	1.4	-0.7	0.5	-0.5	-0.5	-0.0	2.0
Height	2.6	49.3	94.9	-8.4	-8.9	0.4	1.9	-8.9	9.2	-7.7	-4.7	-9.7	0.3
Waist Hip Ratio (WHR)	3.8	17.2	29.2	-4.2	-5.2	-0.3	0.3	-5.3	5.0	-5.3	-3.9	-5.4	0.8
Systolic Blood Pressure	0.2	1.1	4.1	-0.2	0.6	-2.0	0.9	0.4	-0.7	-0.2	0.1	1.2	2.0
Smoking Status	0.2	0.6	3.8	-0.2	-0.3	2.0	-0.6	-0.3	0.3	0.3	0.6	-0.5	-0.6
Allergy or Eczema	1.2	3.1	5.0	-2.1	-2.2	-1.7	0.3	-2.2	1.9	-1.8	-1.6	-2.0	0.3
Cardiovascular Disease	0.4	1.4	6.7	-1.0	-0.6	-1.6	1.3	-0.6	0.4	-0.9	0.2	0.2	2.6
Hypothyroidism (self reported)	1.3	3.0	7.0	2.6	1.8	0.2	-1.2	1.8	-2.2	1.9	1.6	1.9	-0.4
Respiratory disease	0.5	1.1	2.5	-0.9	-1.3	1.0	0.4	-1.2	1.3	-1.6	-0.4	-1.4	-0.3
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.9	1.4	-0.5	0.1	-0.2	-0.5	0.3	0.2	1.1	-0.1	1.1
Lung FEV1/FVC ratio	0.3	1.5	5.2	0.1	1.0	-0.6	-1.2	0.9	-0.8	2.3	-1.6	0.6	-1.6
Lung FVC	0.4	1.8	3.1	1.7	1.6	1.0	0.3	1.8	-1.4	1.7	1.1	1.5	-0.3
Neuroticism	0.1	0.3	1.3	-0.2	-0.2	-1.1	-0.5	-0.2	0.4	-0.3	-0.7	-0.4	-0.2
Chronotype (morning person)	0.8	1.7	3.1	-1.5	-1.7	-0.5	0.7	-1.8	1.4	-1.7	-0.5	-1.3	1.4
Hair Pigment	0.1	2.1	4.0	0.9	1.9	0.1	-1.9	1.8	-2.0	1.3	0.6	1.8	-0.9
Tanning	0.1	1.2	2.3	1.0	1.2	-0.3	-1.5	1.0	-1.4	1.5	0.7	1.1	-0.9
Hand grip strength (left)	0.5	1.4	5.8	1.4	0.2	2.4	0.4	0.4	0.1	0.9	1.6	-0.6	-1.4
Number of treatments/medications taken	1.0	1.8	4.2	-2.0	-1.4	-0.4	-0.1	-1.6	1.2	-1.5	-1.9	-1.4	0.4
Average weekly spirits intake	1.2	1.5	6.8	-0.3	0.8	-0.2	-2.6	0.5	-0.8	1.6	0.7	0.3	-1.9
Sensitivity / hurt feelings	0.1	0.1	0.7	-0.5	0.2	0.1	-0.3	0.2	-0.0	0.4	-0.0	-0.1	-0.8
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.5	1.2	1.0	0.0	-0.5	1.0	-1.0	0.9	0.5	1.0	-0.1
Hearing difficulty/problems: Yes	1.5	2.3	4.4	-1.4	-1.7	-1.1	0.6	-1.9	1.7	-2.1	-1.1	-1.3	1.7
Relative age of first facial hair	0.1	0.2	0.6	-0.1	0.1	-0.6	-0.8	-0.2	-0.3	-0.0	-0.3	0.1	-0.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.1	-1.1	-0.9	0.5	-0.2	-0.9	0.6	-0.4	0.1	-0.9	-0.3
Ever used hormone-replacement therapy (HRT)	0.6	0.8	4.9	-0.9	-0.6	2.2	-0.1	-0.3	0.7	-0.3	-0.4	-0.6	-0.5
Ever had hysterectomy (womb removed)	2.2	2.5	5.4	-0.6	-2.2	0.4	-0.2	-2.1	2.1	-1.9	-1.4	-2.3	-0.3
Systolic blood pressure, automated reading	0.3	0.8	2.4	-0.3	0.9	-1.5	-0.5	0.7	-1.2	0.4	0.5	1.3	0.8
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.8	-0.1	-1.3	-0.1	0.9	-1.2	1.1	-1.3	0.2	-0.7	1.7
Angina	0.2	0.2	1.1	-0.6	-0.3	1.0	-0.6	-0.2	0.1	-0.1	0.1	-0.3	-0.3
Medication for hormone replacement therapy	0.9	1.0	3.8	-1.0	-1.1	-0.5	0.9	-0.9	0.9	-1.2	-0.0	-0.2	1.9
Vitamin and mineral supplements	0.6	0.9	4.0	0.1	-0.5	-0.6	1.6	-0.3	0.2	-0.3	1.0	0.2	2.0
Supplements: Zinc	0.8	0.9	5.6	0.9	0.1	2.4	-0.3	0.0	0.0	0.5	1.2	-0.3	-0.6
Medication: Co-codamol	0.9	1.1	2.7	-1.7	-0.9	-1.3	0.3	-1.1	0.8	-1.1	-0.5	-0.5	1.3
Medication: Metformin	0.6	0.8	1.9	0.3	-1.3	-1.1	-0.2	-1.4	1.0	-0.8	0.5	-0.9	1.0
Diabetes (father)	0.3	0.4	1.2	-0.4	-0.6	-1.1	1.0	-0.4	0.5	-0.3	-0.3	-0.4	0.5
Diabetes (mother)	1.0	1.3	3.1	1.8	1.5	0.4	0.0	1.5	-1.3	1.3	0.1	1.3	-0.4
Severe depression (siblings)	0.1	0.1	0.3	-0.1	0.1	0.4	0.6	0.2	0.0	0.2	-0.2	0.1	0.0
Pack years adult smoking proportion	1.2	1.8	4.8	0.7	1.6	0.0	-1.7	1.4	-1.4	2.2	1.1	1.3	-0.7
Impedance of leg (right)	0.6	2.8	5.5	2.1	2.0	0.8	-0.3	2.0	-2.1	1.9	1.2	2.3	0.5
Leg fat-free mass (left)	1.3	7.0	13.7	-2.9	-3.5	-0.3	1.3	-3.3	3.6	-2.7	-1.3	-3.7	0.5
Trunk fat percentage	0.4	1.5	8.9	-0.9	-0.5	-0.8	1.6	-0.5	0.1	-0.5	0.7	0.6	3.0
Hand grip strength (right)	0.3	0.8	3.5	0.8	-0.3	1.9	1.1	-0.1	0.5	0.3	1.4	-0.6	-0.3
Townsend deprivation index at recruitment	0.1	0.1	0.4	-0.6	0.3	-0.0	-0.1	0.1	-0.3	0.3	-0.5	0.1	-0.4
Current tobacco smoking	0.3	0.6	2.2	1.1	0.5	1.5	-0.7	0.5	-0.4	0.9	0.2	0.2	-0.6
Average weekly fortified wine intake	0.1	0.1	0.6	0.4	0.1	-0.8	-0.3	0.1	-0.2	0.3	0.4	0.0	0.1
Maternal smoking around birth	0.2	0.2	0.7	-0.3	0.4	-0.8	-0.6	0.1	-0.5	0.1	-0.8	0.3	-0.3
Fed-up feelings	0.7	1.2	4.8	-0.4	-0.8	-1.4	1.5	-0.7	0.7	-0.9	-0.6	-0.0	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.0	1.7	1.1	-0.3	-0.2	1.1	-1.4	0.9	0.9	1.5	0.9
Relative age voice broke	0.1	0.2	0.9	-0.4	0.0	-0.7	-1.0	-0.3	-0.4	-0.2	-0.1	0.3	0.1
Taking other prescription medications	0.4	0.6	1.6	-1.1	-0.6	1.3	-0.6	-0.7	0.5	-0.5	0.1	-0.9	-1.0
Age when periods started (menarche)	0.1	0.2	0.8	0.9	-0.1	0.5	-0.8	-0.0	0.0	-0.2	0.0	-0.2	-0.6
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.5	1.2	0.7	0.6	-0.7	0.8	-1.0	0.8	1.0	1.0	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.6	1.2	0.3	1.1	-1.3	0.2	-0.3	0.5	1.0	0.1	-0.3
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	2.3	-0.6	0.6	-0.3	-1.5	0.4	-0.4	0.4	-0.1	0.1	-1.4
Qualifications: CSEs or equivalent	0.4	0.5	2.7	-0.5	-0.2	0.8	0.6	-0.2	0.0	-0.1	1.6	0.1	0.9
Serious illness, injury or assault to yourself	0.3	0.4	1.6	0.2	-0.3	0.9	-0.6	-0.2	0.2	0.3	1.3	-0.4	-0.7
High blood pressure	0.6	1.7	7.5	-1.2	-1.0	-1.2	1.3	-1.1	0.8	-1.5	-0.2	-0.3	2.7
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.5	-1.2	-1.2	-1.1	0.5	-1.2	1.1	-1.0	-0.7	-1.1	0.4
Multivitamins +/- minerals	0.7	0.9	4.9	0.4	0.5	0.6	-1.7	0.3	-0.3	0.4	-0.8	-0.2	-2.2
Stomach or abdominal pain in last month	0.4	0.5	0.9	-0.8	-0.9	0.4	-0.4	-0.9	0.9	-0.9	0.4	-0.8	0.3
Supplements: Glucosamine	1.2	1.6	5.3	0.6	1.0	1.6	-0.5	1.2	-1.0	1.5	2.3	0.8	-1.2
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.0	-0.9	-1.6	0.1	-0.3	-1.7	1.5	-1.4	-0.2	-1.7	-0.0
Medication: Atenolol	0.4	0.5	1.8	-1.0	-0.5	0.2	0.8	-0.3	0.3	-0.8	0.1	-0.1	1.3
Medication: Levothyroxine sodium	0.4	0.7	2.5	1.0	0.7	-0.5	-1.6	0.5	-1.1	0.8	0.2	0.8	-0.4
Sitting height	0.6	4.4	10.7	-1.3	-3.0	0.9	1.4	-2.7	3.3	-1.4	-0.7	-3.3	0.4
Chronic bronchitis/emphysema (father)	1.1	1.2	3.5	0.1	1.4	-0.4	0.9	1.5	-1.6	0.8	-0.7	1.9	0.5
High blood pressure (mother)	1.1	1.6	2.7	1.5	1.5	-0.5	-0.9	1.5	-1.6	1.5	0.2	1.4	-0.9
Body mass index (BMI)	0.1	0.6	2.0	-0.9	-0.7	-0.9	0.9	-0.7	0.5	-0.5	-0.0	-0.2	1.4
Impedance of leg (left)	0.3	1.5	3.6	1.3	1.5	0.4	-0.1	1.5	-1.5	1.2	0.8	1.9	0.9
Leg predicted mass (left)	1.3	6.7	13.3	-2.9	-3.4	-0.3	1.2	-3.3	3.6	-2.7	-1.3	-3.6	0.5
Trunk fat mass	0.6	2.6	8.1	-1.8	-1.7	-0.6	2.0	-1.6	1.5	-1.4	0.1	-0.9	2.9
Waist circumference	0.9	3.4	6.0	-2.4	-2.2	-1.0	1.2	-2.2	2.0	-2.0	-1.4	-1.8	1.7
Number of incorrect matches in round	0.2	0.3	1.8	-1.4	0.1	-0.7	0.1	-0.1	-0.3	-0.5	-0.7	0.3	0.3
Past tobacco smoking	0.4	0.7	2.4	1.6	1.1	0.1	-0.2	1.0	-0.9	0.8	0.2	0.9	-0.3
Alcohol usually taken with meals	0.2	0.4	1.7	1.3	0.2	0.5	0.2	0.4	-0.2	0.6	1.1	0.0	-0.2
Nervous feelings	0.6	1.2	2.1	-0.2	1.4	-1.2	-1.4	1.1	-1.4	0.9	-0.2	1.2	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.8	0.9	0.1	-0.1	0.6	0.3	-0.2	-0.0	-0.2	0.3	0.4
Hearing difficulty/problems with background noise	1.8	2.9	6.6	-1.6	-1.6	-1.2	1.6	-1.6	1.8	-2.3	-1.0	-1.1	2.6
Hair/balding pattern: Pattern 2	1.4	1.8	3.2	0.6	1.8	-1.3	-0.7	1.6	-1.7	1.3	-1.0	1.6	-0.9
Had menopause	1.2	1.5	4.4	0.6	1.4	-0.0	-0.7	1.4	-1.5	2.1	0.9	1.4	-0.9
Had other major operations	0.6	0.7	3.6	0.7	-0.0	0.3	-1.9	0.0	-0.0	0.7	0.3	-0.3	-1.4
Forced vital capacity (FVC)	0.3	1.3	4.2	0.4	-1.0	2.0	1.1	-0.6	1.6	-0.3	0.6	-1.6	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.8	0.4	-0.6	0.4	0.1	-0.7	0.5	-0.5	0.6	-0.3	1.3
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	3.0	-0.3	-1.4	1.2	-0.3	-1.3	1.5	-0.9	-0.6	-1.7	-0.5
Qualifications: None of the above	0.8	1.7	4.8	1.5	1.2	2.2	0.4	1.2	-1.2	0.9	1.4	1.5	0.4
Financial difficulties in last 2 years	1.3	1.7	3.1	-0.7	-1.6	-0.5	-0.3	-1.8	1.7	-1.7	-1.3	-1.7	-0.1
Mouth/teeth dental problems	0.2	0.2	1.4	-0.0	-0.1	-0.1	-1.2	-0.1	0.0	-0.0	0.1	-0.3	-0.9
Heart attack	0.3	0.4	1.8	0.7	-0.2	1.3	-0.3	-0.2	0.1	0.2	1.0	-0.2	0.0
Allergy	0.4	1.0	1.6	1.3	1.3	0.4	-1.0	1.1	-1.2	1.0	0.5	1.0	-0.5
Pain all over the body in last month	0.4	0.5	1.7	0.2	0.2	-1.3	0.5	0.5	-0.3	-0.2	-0.0	0.8	1.3
Diabetes (self-reported)	0.6	0.9	2.1	0.0	-1.4	-0.3	-0.2	-1.5	1.2	-1.0	0.3	-0.9	1.2
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	4.4	-0.9	-0.6	-2.1	0.0	-0.7	0.6	-1.2	-1.9	-0.5	-0.1
Medication: Ramipril	0.3	0.4	2.2	0.2	0.5	-1.5	0.6	0.4	-0.3	0.2	-0.2	0.6	0.9
Medication: Simvastatin	0.3	0.4	1.1	-0.9	-0.6	0.7	0.9	-0.4	0.4	-0.5	-0.1	-0.3	1.0
Fluid intelligence score	1.4	2.9	6.0	1.6	1.9	-2.4	-1.6	1.7	-2.1	1.8	-0.4	1.9	-0.7
Illnesses of siblings	0.1	0.2	0.5	0.7	-0.3	0.3	0.7	-0.1	0.3	-0.6	-0.1	-0.3	0.1
Neuroticism score	0.3	0.7	1.5	0.6	1.1	-1.2	-0.6	1.0	-0.9	0.7	-0.3	1.0	-0.3
Weight	1.1	5.3	9.1	-2.6	-3.0	-0.3	1.7	-2.9	3.0	-2.3	-0.7	-2.8	1.7
Impedance of arm (right)	0.9	4.2	10.4	1.8	2.6	-0.4	-0.3	2.5	-2.8	2.1	1.4	3.2	1.1
Arm fat percentage (right)	0.4	1.4	7.0	-0.0	0.4	-1.0	1.3	0.4	-0.8	0.4	1.1	1.5	2.6
Trunk fat-free mass	2.0	11.2	25.0	-3.4	-4.4	0.4	1.5	-4.1	4.7	-3.4	-1.9	-5.0	-0.1
Hip circumference	0.2	1.0	3.8	-0.6	0.2	-0.8	1.9	0.3	-0.1	0.5	0.9	0.7	2.0
Time employed in main current job	0.9	1.1	2.3	-0.8	-1.1	1.1	1.5	-1.0	1.1	-1.1	0.6	-0.7	1.1
Alcohol intake versus 10 years previously	0.2	0.3	0.6	0.5	0.6	-0.2	-0.8	0.5	-0.6	0.5	0.3	0.7	0.4
Father’s age at death	1.2	1.6	2.7	0.7	1.5	0.8	1.3	1.6	-1.2	1.6	1.4	1.3	-0.5
Worrier / anxious feelings	0.2	0.4	2.1	0.1	0.7	-1.4	0.1	0.6	-0.5	0.1	-0.6	0.7	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.7	-0.8	-0.4	-0.4	-0.7	-0.4	0.3	-0.3	0.6	-0.2	0.4
Falls in the last year	0.4	0.5	1.3	-0.2	-1.1	0.1	-0.1	-1.1	0.8	-0.8	-0.4	-1.0	-0.1
Hair/balding pattern: Pattern 3	0.3	0.5	1.0	-0.0	-0.9	-0.2	-0.8	-1.0	0.9	-0.3	0.4	-1.0	-0.3
Number of live births	1.9	2.7	8.1	1.9	1.1	2.9	-1.6	1.4	-0.9	1.6	1.7	0.6	-1.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	2.2	0.4	-0.7	1.5	1.1	-0.3	1.2	0.1	0.1	-1.2	-0.4
Pulse rate	0.1	0.1	0.6	-0.2	-0.2	-0.4	0.2	-0.2	-0.0	-0.4	-0.0	0.2	0.8
Happiness	0.1	0.1	0.5	0.1	0.1	-0.0	-0.7	0.1	-0.1	0.1	-0.2	0.0	-0.3
Noisy workplace	1.8	2.2	4.2	-1.3	-2.0	0.5	0.2	-2.1	1.7	-1.9	0.7	-1.6	1.4
Qualifications: A levels/AS levels or equivalent	0.3	0.8	2.0	-0.8	-0.8	-0.6	-0.1	-0.9	1.0	-0.2	-1.4	-1.3	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.3	-0.0	0.3	0.3	-0.7	0.3	-0.4	0.4	0.3	0.1	-1.1
Mouth/teeth dental problems: Dentures	0.4	0.7	2.2	-0.9	-0.8	0.9	1.5	-0.8	0.7	-0.4	0.0	-0.6	0.7
Asthma	0.7	1.5	3.3	-1.8	-1.2	-1.0	1.0	-1.2	1.2	-1.6	-1.1	-1.1	0.3
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	8.5	0.2	-0.1	-2.9	-0.3	-0.6	0.1	-0.5	-2.8	-0.2	0.3
Medication: Cholesterol lowering	1.2	1.8	4.0	-0.9	-1.9	0.3	0.2	-2.0	1.8	-1.6	-0.0	-1.9	0.7
Depression (self-reported)	0.4	0.4	2.7	0.3	0.5	-0.6	0.6	0.5	-0.2	0.2	-1.6	0.4	0.2
Medication: Lansoprazole	1.1	1.3	5.1	-0.6	0.7	-1.2	-2.3	0.5	-1.0	0.7	-1.3	0.6	-1.2
Prospective memory result	1.9	2.3	5.3	-0.8	-2.1	-0.0	0.4	-2.3	1.9	-2.2	-0.5	-1.8	0.9
Lung cancer (father)	1.2	1.4	4.9	-2.1	-0.4	-1.3	1.5	-0.4	0.4	-0.7	-0.1	0.2	2.2
Illnesses of mother	2.6	3.2	5.8	-2.4	-2.0	-0.3	1.7	-1.9	2.0	-2.4	-1.1	-1.7	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	6.1	0.5	-0.5	2.5	0.7	-0.1	1.0	0.4	0.8	-1.2	-1.1
Pulse wave Arterial Stiffness index	1.0	1.2	2.9	0.1	1.3	-1.7	-0.5	1.2	-1.5	0.8	0.4	1.6	0.1
Impedance of arm (left)	0.7	3.2	8.0	1.4	2.3	-0.2	-0.3	2.2	-2.5	1.8	1.4	2.8	0.9
Arm fat mass (right)	0.3	1.2	4.4	-1.2	-1.0	-0.7	1.5	-0.9	0.8	-0.7	0.2	-0.3	2.1
Trunk predicted mass	2.0	11.7	26.0	-3.4	-4.5	0.3	1.5	-4.2	4.8	-3.4	-2.0	-5.1	-0.1
Standing height	1.5	15.4	32.9	-3.8	-5.2	1.1	1.8	-4.8	5.6	-4.1	-1.5	-5.7	0.7
Length of working week for main job	1.1	1.2	2.4	-0.3	-1.3	0.1	-1.0	-1.4	1.1	-1.1	-1.5	-1.5	-0.9
Exposure to tobacco smoke at home	1.1	1.2	2.7	-0.0	1.2	-1.2	1.2	1.2	-1.2	0.8	-0.6	1.6	1.0
Breastfed as a baby	1.2	1.5	2.7	-1.5	-1.5	-0.8	-1.0	-1.6	1.4	-1.2	0.2	-1.6	-0.2
Tense / ‘highly strung’	1.0	1.6	5.9	-1.6	-0.3	-2.2	0.1	-0.6	0.3	-1.4	-2.4	-0.2	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	2.4	-0.0	0.5	0.3	-1.2	0.3	-0.5	0.7	-0.5	-0.0	-1.6
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	0.4	0.6	0.7	-0.4	0.6	-0.7	0.3	0.3	0.6	-0.6
Birth weight of first child	6.6	12.0	19.9	-3.2	-4.3	-0.2	2.5	-4.5	4.4	-4.3	-1.9	-4.1	2.5
Peak expiratory flow (PEF)	0.5	1.2	4.0	1.2	0.8	1.0	-0.1	1.2	-0.8	2.0	1.2	0.6	-0.9
Pulse wave reflection index	2.6	3.2	5.1	0.6	2.2	-1.8	-2.1	1.9	-2.3	2.3	-0.1	2.1	-1.1
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.0	-0.3	-0.5	0.7	0.2	-0.4	0.7	-0.2	-1.4	-0.8	-0.5
Loud music exposure frequency	0.3	0.3	0.7	0.2	0.5	0.4	0.9	0.5	-0.3	0.2	0.2	0.6	0.8
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	6.5	-1.6	-0.4	-1.3	-0.1	-0.5	0.7	-0.6	-2.6	-0.9	-1.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.9	0.4	0.1	0.7	1.0	0.2	-0.1	0.2	0.7	0.4	0.9
Blood clot in the leg (DVT)	0.3	0.4	2.1	0.2	-0.5	1.4	0.4	-0.4	0.5	-0.0	1.0	-0.5	0.2
Medication: Paracetamol	1.2	2.0	4.2	-1.7	-1.6	-0.8	0.6	-1.7	1.5	-1.7	-0.7	-1.0	2.1
Headache pain in last month	0.2	0.3	0.9	-0.4	-0.2	0.6	-0.9	-0.4	0.1	0.0	0.9	-0.2	-0.5
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	5.8	1.7	1.7	0.3	-2.1	1.8	-1.7	2.0	-0.1	1.2	-2.4
Glaucoma (self-reported)	0.4	0.5	1.7	0.1	0.7	0.3	-1.1	0.6	-0.7	0.4	-0.1	0.4	-1.3
Gout (self-reported)	0.1	0.2	0.5	-0.0	-0.5	-0.4	0.2	-0.5	0.3	-0.7	0.2	-0.3	0.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.2	1.0	0.0	0.2	-0.8	0.0	-0.4	0.1	1.1	0.2	0.1
Medication: Amlodipine	0.3	0.4	1.7	-0.8	-0.2	0.2	1.3	-0.0	0.4	-0.2	-0.7	-0.1	1.0
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.3	0.3	0.8	0.8	1.1	0.9	-0.6	0.9	0.9	0.7	-0.3
Birth weight	13.9	30.3	68.9	-4.1	-7.5	1.3	0.3	-7.3	7.5	-6.2	-3.1	-8.3	-0.8
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.8	0.7	1.0	0.1	-1.3	0.9	-0.9	0.9	1.2	0.6	-1.1
High blood pressure (siblings)	1.0	1.4	3.5	0.6	1.6	0.4	-0.3	1.6	-1.4	1.9	1.1	1.5	-0.1
Forced vital capacity (FVC), Best measure	0.4	1.5	6.7	0.6	-0.8	2.6	0.7	-0.4	1.2	-0.2	1.4	-1.5	-0.9
Body fat percentage	0.3	1.3	8.4	-0.6	-0.2	-0.8	1.5	-0.2	-0.1	-0.2	0.8	0.8	2.9
Leg fat percentage (right)	0.3	1.1	4.3	0.4	0.7	-0.6	1.1	0.7	-1.0	0.7	0.8	1.5	2.1
Arm fat-free mass (right)	2.1	10.7	22.8	-3.2	-4.3	0.4	1.7	-4.0	4.6	-3.4	-1.6	-4.8	0.4
Exposure to tobacco smoke outside home	0.4	0.6	1.1	0.1	0.9	-0.8	-0.1	0.9	-1.0	0.8	0.4	1.1	-0.4
Comparative body size at age 10	0.2	0.6	1.3	1.0	-0.7	0.9	-0.2	-0.7	0.8	-0.7	0.3	-1.2	-1.0
Number of full brothers	0.4	0.5	1.3	-1.1	-0.7	-0.4	0.3	-0.7	0.7	-0.8	-0.2	-0.4	1.1
Worry too long after embarrassment	2.1	3.5	9.6	1.7	1.9	0.4	-2.7	1.6	-1.5	2.4	0.5	0.9	-3.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.8	-0.4	0.2	-0.6	-0.6	-0.1	-0.0	0.1	-0.9	0.0	-0.5
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	-0.1	0.5	-0.4	-0.3	0.5	-0.4	0.2	0.1	0.5	-0.2
Number of children fathered	2.3	2.6	5.8	-1.4	-2.1	-0.3	0.3	-2.2	1.7	-2.4	-1.1	-1.8	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.1	-0.3	-0.6	-0.5	-0.5	-0.7	0.6	-0.8	-0.7	-0.8	-1.1
Age at first live birth	0.8	1.3	4.1	1.4	0.2	-0.1	1.9	0.5	-0.5	0.4	1.5	1.0	2.0
Pulse wave peak to peak time	1.4	1.7	3.7	-0.2	-1.6	1.9	0.7	-1.4	1.8	-1.1	-0.5	-1.9	-0.0
Health satisfaction	1.0	1.3	2.3	-1.0	-1.5	-0.3	0.1	-1.4	1.5	-1.4	-1.2	-1.5	0.3
Shortness of breath walking on level ground	2.0	2.4	7.6	-0.3	-1.4	0.1	2.6	-1.1	1.4	-1.8	0.8	-0.7	2.8
Qualifications: College or University degree	0.1	0.2	0.6	0.6	-0.5	0.2	0.4	-0.3	0.7	-0.3	-0.1	-0.8	-0.3
Eye problems/disorders: None of the above	0.9	1.1	3.2	0.4	0.9	-1.6	-0.5	0.8	-1.2	0.8	-1.8	1.0	-0.1
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.6	-0.5	-0.2	-0.4	0.5	-0.2	0.4	-0.8	-0.2	-0.3	-0.2
Emphysema/chronic bronchitis	0.4	0.4	2.1	-0.3	-0.5	1.4	-0.6	-0.6	0.4	-0.7	0.2	-0.7	-0.4
Medication for pain relief, constipation, heartburn	2.6	4.4	7.6	2.3	2.5	0.9	-0.5	2.7	-2.2	2.8	1.7	1.9	-2.1
Neck or shoulder pain in last month	0.6	0.8	3.4	-1.2	-0.8	0.6	-0.0	-1.0	0.7	-0.2	1.9	-0.7	0.7
Medication: Blood pressure	2.2	3.9	11.0	-1.6	-1.9	-0.2	3.3	-1.7	1.9	-2.2	-0.2	-1.2	3.1
Angina (self-reported)	0.2	0.2	0.6	-0.7	-0.6	0.8	-0.4	-0.5	0.3	-0.4	0.1	-0.4	0.1
Migraine (self-reported)	0.5	0.6	3.7	-0.3	-0.6	0.2	1.0	-0.5	0.5	-0.6	0.5	0.0	1.9
Medication: Ibuprofen	0.7	0.9	3.4	0.5	0.5	-1.9	0.6	0.2	-0.5	0.0	-1.7	0.7	0.8
Medication: Allopurinol	0.4	0.5	1.0	-1.0	-0.5	-1.0	0.2	-0.7	0.3	-0.8	-0.7	-0.2	0.9
Medication: Omeprazole	1.9	2.2	3.5	-1.4	-1.8	0.5	1.4	-1.7	1.9	-1.9	-0.1	-1.5	1.7
Medication: Seretide 50 evohaler	0.6	0.7	1.6	1.0	0.7	1.2	0.1	0.8	-0.5	1.0	1.2	0.3	-0.5
Mean time to correctly identify matches	0.2	0.4	1.3	-1.1	0.4	1.0	0.3	0.5	-0.5	-0.1	-0.0	0.7	-0.0
Heart disease (mother)	3.4	4.1	11.1	1.9	2.0	0.4	-3.3	1.6	-2.0	2.8	0.6	1.2	-2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.2	0.6	1.2	-1.5	-0.5	1.0	-1.2	0.9	-0.5	1.0	-0.8
Whole body fat mass	0.5	1.9	6.6	-1.4	-1.4	-0.6	1.8	-1.4	1.2	-1.1	0.2	-0.7	2.6
Leg fat mass (right)	0.3	1.3	4.6	-1.0	-1.2	-0.4	1.5	-1.1	1.0	-0.8	0.3	-0.6	2.1
Arm predicted mass (right)	2.2	11.1	23.2	-3.3	-4.4	0.5	1.8	-4.1	4.7	-3.5	-1.5	-4.8	0.5
Pulse rate, automated reading	1.7	5.6	15.0	1.0	3.0	-1.7	0.7	3.0	-3.1	2.1	1.1	3.9	1.9
Alcohol intake frequency.	0.4	0.8	1.9	0.9	0.9	0.5	1.0	0.9	-1.1	0.7	0.5	1.4	1.1
Comparative height size at age 10	2.5	13.7	27.2	-3.0	-5.0	1.4	2.1	-4.6	5.2	-4.3	-1.1	-5.1	1.6
Number of full sisters	1.5	1.9	4.4	-1.3	-1.7	0.9	-0.4	-1.6	1.8	-1.5	-0.5	-2.1	-0.8
Suffer from ‘nerves’	1.1	1.7	4.1	0.9	1.4	0.5	-1.5	1.4	-1.5	1.4	0.2	1.1	-2.0
Overall health rating	0.2	0.5	2.4	-0.3	-0.8	-0.1	0.0	-0.8	0.5	-0.6	0.7	-0.2	1.6
Chest pain or discomfort	0.8	1.1	2.9	0.8	1.1	-0.1	-1.5	0.9	-1.0	1.1	-0.6	0.6	-1.7
Had major operations	1.2	1.5	3.3	-1.8	-1.5	0.3	-0.8	-1.4	1.5	-0.7	-0.5	-1.8	-0.3
Age at last live birth	0.9	1.3	3.6	1.2	0.2	0.8	1.9	0.6	-0.4	0.1	1.6	1.0	1.7
Family relationship satisfaction	0.7	0.9	2.6	-0.4	0.6	-0.7	-1.6	0.5	-0.7	0.7	-1.3	0.3	-1.4
Leg pain on walking	0.9	1.1	2.1	-1.4	-1.2	1.2	0.5	-1.0	1.3	-1.1	0.5	-1.2	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	1.7	-0.3	0.3	-0.2	-0.1	0.3	-0.5	0.2	-1.3	0.3	-0.1
Commuting to job workplace: Car/motor vehicle	0.8	1.0	3.2	1.0	0.9	1.8	0.9	1.3	-0.6	0.8	0.8	0.7	-0.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.6	0.3	0.5	0.7	0.9	0.6	-0.5	0.4	1.3	0.6	0.5
Medication: Aspirin	1.1	1.5	2.9	-1.3	-1.5	1.1	-0.2	-1.6	1.4	-1.5	0.1	-1.7	-0.1
Supplements: Vitamin C	0.5	0.5	2.5	-0.7	-0.2	1.1	-0.8	-0.1	0.4	-0.1	0.0	-0.7	-1.6
Knee pain experienced in last month	0.2	0.3	1.3	-0.6	-0.3	0.7	-0.8	-0.5	0.2	-0.2	1.1	-0.3	0.1
Hypertension (Self-reported)	0.4	1.0	5.6	-0.6	-0.4	-1.1	1.3	-0.4	0.3	-0.8	0.1	0.2	2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	-0.3	-0.1	0.4	0.2	-0.1	0.1	-0.5	-0.6	-0.1	0.1
Illnesses of father: Heart disease	2.6	3.6	10.5	1.7	2.1	-0.6	-3.2	1.8	-1.8	2.1	0.3	1.4	-2.2
Illnesses of siblings: Diabetes	0.2	0.3	0.6	-0.4	-0.8	-0.1	0.2	-0.7	0.6	-0.7	-0.5	-0.7	-0.1
Smoking status: Previous	0.4	0.6	2.8	-1.7	-0.7	-1.2	-0.0	-0.7	0.4	-0.6	-0.4	-0.4	0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	5.5	-1.0	-1.9	0.4	1.1	-1.7	2.4	-1.0	-0.5	-2.3	-0.2
Whole body fat-free mass	1.9	10.7	22.8	-3.4	-4.3	0.0	1.4	-4.1	4.5	-3.3	-1.9	-4.8	0.1
Leg fat-free mass (right)	1.5	7.9	15.4	-3.2	-3.6	-0.4	1.3	-3.5	3.9	-3.0	-1.4	-3.9	0.5
Arm fat percentage (left)	0.3	1.3	6.7	-0.3	0.3	-1.1	1.3	0.2	-0.6	0.2	1.0	1.2	2.6
Average weekly red wine intake	0.5	0.7	2.7	0.6	-0.6	-1.7	-0.5	-0.8	0.6	-0.3	-1.2	-0.7	-0.1
Handedness (chirality/laterality): Left-handed	3.1	3.7	7.7	1.6	2.6	0.0	0.3	2.8	-2.5	2.4	1.0	2.7	-0.3
Mood swings	0.3	0.5	1.8	0.7	0.6	-0.2	0.8	0.6	-0.6	0.0	-0.0	1.1	1.3
Loneliness, isolation	1.0	1.4	2.8	-1.2	-1.3	-0.8	-0.3	-1.5	1.4	-1.2	-1.7	-1.5	0.4
Long-standing illness, disability or infirmity	1.1	1.6	3.8	-1.7	-1.5	2.0	0.3	-1.5	1.2	-1.1	-0.1	-1.4	-0.2
Ever had bowel cancer screening	0.2	0.3	1.0	-0.9	0.2	-0.5	-0.5	0.2	-0.3	-0.2	-1.0	0.2	-0.5
Diabetes diagnosed by doctor	0.4	0.7	2.0	0.4	-1.1	-0.2	0.1	-1.1	1.0	-0.7	0.4	-0.7	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.7	0.7	0.1	1.3	0.4	0.4	0.2	-0.0	-0.0	-0.1	-0.8
Friendships satisfaction	0.3	0.4	1.5	-1.1	0.1	0.4	1.2	0.2	0.1	0.1	-0.5	0.2	0.7
Qualifications: nursing, teaching	0.3	0.4	1.8	0.6	0.2	-0.3	-1.4	0.0	-0.3	0.7	1.1	0.2	-0.5
Commuting to job workplace: Walk	0.7	0.7	4.7	-0.5	0.0	-2.2	-0.8	-0.2	-0.3	-0.2	-0.9	0.4	0.6
Eye problems/disorders: Cataract	1.0	1.1	3.8	-0.4	-0.7	0.0	1.8	-0.5	0.7	-0.2	1.9	-0.2	1.7
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	1.2	0.1	-0.3	-0.8	0.1	-0.3	0.2	-0.5	-0.1	0.1	1.1
Medication for cholesterol	0.2	0.4	0.9	0.7	-0.3	0.8	0.1	-0.4	0.7	-0.3	-0.2	-0.9	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	6.9	8.2	13.0	-2.3	-3.6	-0.1	2.6	-3.5	3.5	-3.5	-2.1	-3.1	2.4
Back pain experienced in last month	0.3	0.4	1.7	0.8	0.2	1.3	0.5	0.3	-0.3	0.4	0.8	0.3	0.4
Mineral and other dietary supplements	1.0	1.3	4.2	-1.1	-0.6	-2.0	0.8	-0.8	0.7	-1.0	-1.6	-0.4	1.4
Breast cancer (self-reported)	5.3	6.3	10.3	2.6	3.0	1.6	-2.0	3.1	-2.7	3.2	1.7	2.4	-2.1
Asthma (self-reported)	0.9	1.7	3.3	-1.8	-1.4	-1.0	0.8	-1.4	1.3	-1.7	-1.4	-1.3	0.1
Osteoporosis (self-reported)	0.8	1.0	2.7	-0.3	-1.0	1.1	-0.3	-1.0	1.1	-0.2	-0.5	-1.6	-1.6
Osteoarthritis (self-reported)	0.7	0.9	4.2	-0.8	-0.6	2.0	-0.9	-0.6	0.1	-0.7	1.3	-0.4	-0.2
Medication: Aspirin	1.5	2.0	3.7	-1.7	-1.8	0.3	0.1	-1.9	1.6	-1.9	-0.4	-1.8	0.4
Medication: Gliclazide	0.9	1.0	2.0	-0.3	-1.1	-0.5	-1.4	-1.4	0.8	-0.8	-0.8	-1.4	-1.0
Illnesses of father: None of the above (group 1)	1.1	1.3	1.9	-1.3	-1.4	0.5	1.4	-1.3	1.2	-1.3	-0.4	-1.2	0.9
Smoking status: Current	0.2	0.4	3.2	0.5	-0.2	1.8	-0.1	-0.1	0.3	0.2	0.2	-0.4	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.2	-0.2	-0.2	0.2	0.4	-0.2	0.4	0.3	-0.5	-0.5	-0.4
Whole body water mass	1.8	10.5	22.3	-3.4	-4.2	0.0	1.5	-4.0	4.5	-3.3	-1.8	-4.7	0.2
Leg predicted mass (right)	1.5	7.8	15.4	-3.2	-3.6	-0.4	1.2	-3.5	3.8	-2.9	-1.4	-3.9	0.4
Arm fat mass (left)	0.4	1.4	4.5	-1.4	-1.2	-0.7	1.4	-1.2	1.1	-1.0	0.2	-0.6	2.1
Number of self-reported non-cancer illnesses	1.0	1.8	3.7	-1.9	-1.6	0.4	0.5	-1.7	1.4	-1.8	-0.8	-1.4	0.7
Average weekly champagne plus white wine intake	0.4	0.6	2.9	0.2	-0.3	0.5	1.7	0.0	0.7	-0.5	-1.2	-0.6	-0.3
Miserableness	1.4	2.4	4.3	1.4	2.0	-0.3	-0.8	1.9	-2.1	2.0	1.1	1.8	-1.3
Guilty feelings	0.5	0.7	2.9	1.7	0.9	0.3	0.2	1.3	-0.7	0.5	0.1	0.7	-0.7
Wears glasses or contact lenses	0.5	0.6	1.5	-1.2	-0.3	-1.0	1.0	-0.3	0.1	-0.1	-1.0	0.1	0.9
Ever taken oral contraceptive pill	0.4	0.5	1.9	1.1	0.6	0.7	-0.5	0.6	-0.4	0.5	-0.1	0.1	-1.4
Hearing aid user	0.2	0.2	0.8	-0.2	0.2	-0.4	0.3	0.1	-0.2	-0.0	0.7	0.6	0.9
Mother’s age at death	2.2	2.7	7.0	2.7	1.7	0.9	-1.1	1.7	-1.6	1.9	1.8	1.5	-0.9
Financial situation satisfaction	0.3	0.4	1.6	-0.1	-0.3	0.1	-1.3	-0.4	0.3	-0.0	-1.0	-0.6	-0.8
Tinnitus: Yes, now most or all of the time	0.4	0.5	2.4	0.0	-0.5	0.1	0.9	-0.5	0.6	-0.5	0.3	-0.2	1.5
Commuting to job workplace: Public transport	2.0	2.4	7.5	-1.6	-1.4	-2.7	0.4	-1.7	1.2	-1.6	-1.1	-0.9	1.6
Eye problems/disorders: Glaucoma	0.1	0.1	0.6	-0.3	0.1	0.7	-0.3	-0.0	0.2	-0.1	0.2	-0.3	-0.8
Medication: Blood pressure	1.0	1.9	3.6	0.3	1.7	-1.4	-1.5	1.5	-1.9	1.6	-0.0	1.7	-0.5
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.3	-1.1	-0.3	0.8	-0.7	-0.3	0.1	-0.7	-1.0	-0.4	-0.7
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.8	1.7	0.8	1.7	-0.6	1.2	-0.9	0.9	1.1	0.8	-1.2
High cholesterol (Self-reported)	0.3	0.6	1.1	-0.8	-0.8	-0.7	0.5	-1.0	0.7	-1.0	-0.6	-0.6	0.9
Medication: Bendroflumethiazide	0.6	0.9	6.0	-1.0	-0.0	-2.5	0.4	-0.1	-0.1	-0.3	-0.8	0.2	1.2
Medication: Paracetamol	0.3	0.5	1.3	-1.0	-0.5	-0.7	-0.2	-0.6	0.4	-0.5	-0.8	-0.2	1.1
Medication: Lisinopril	0.1	0.1	0.4	-0.3	0.1	-0.2	0.6	0.0	-0.2	0.3	-0.3	0.2	0.0
Medication: Atorvastatin	0.4	0.5	1.0	0.1	-0.8	-0.8	0.2	-1.0	0.8	-0.7	-1.0	-0.8	-0.1
Illnesses of father: High blood pressure	1.2	1.5	5.0	2.2	1.1	1.3	0.2	1.2	-0.9	1.1	1.6	1.0	-0.3
Alcohol drinker status: Never	1.0	1.2	6.6	1.2	0.6	2.6	0.7	0.8	-0.4	0.9	1.2	0.6	0.2
Ever smoked	0.3	0.6	1.4	-1.2	-1.0	0.6	0.7	-0.9	0.9	-0.7	0.2	-0.9	0.4
Basal metabolic rate	1.6	8.7	17.7	-3.1	-3.9	-0.0	1.5	-3.7	4.1	-3.0	-1.5	-4.2	0.5
Leg fat percentage (left)	0.3	1.0	5.3	-0.1	0.3	-0.7	1.2	0.3	-0.6	0.3	0.5	1.2	2.3
Arm fat-free mass (left)	1.7	8.6	18.0	-2.8	-3.9	0.2	1.4	-3.7	4.1	-3.0	-1.6	-4.2	0.4
Number of operations (self-reported)	1.2	1.8	4.6	-0.4	-1.5	0.7	-2.1	-1.6	1.4	-0.6	-0.0	-1.9	-1.4
Average weekly beer plus cider intake	0.2	0.3	1.4	0.7	0.4	0.2	0.5	0.3	-0.5	0.0	0.5	0.7	1.2
Irritability	0.7	1.2	3.0	0.1	1.1	-1.7	0.8	1.1	-1.0	0.5	-0.4	1.5	1.4
Risk taking	2.6	3.8	7.0	-1.4	-2.5	1.8	1.5	-2.3	2.7	-2.4	0.0	-2.6	0.4
Ever had prostate specific antigen (PSA) test	0.3	0.3	2.3	-0.8	0.0	-1.5	-0.4	-0.1	-0.1	0.4	-0.3	-0.0	-0.3
Fractured/broken bones in last 5 years	0.3	0.4	1.5	0.9	0.5	-0.4	0.4	0.4	-0.5	0.7	1.2	0.6	0.1
Age started oral contraceptive pill	0.8	1.0	4.5	-0.1	0.3	-1.1	-2.1	-0.0	-0.4	-0.0	-1.1	-0.1	-1.7
Diastolic blood pressure, automated reading	0.2	0.8	2.6	-1.6	-0.7	-1.0	-0.9	-1.0	0.6	-0.5	-0.8	-0.7	0.1
Ever depressed for a whole week	0.3	0.4	1.2	0.2	0.6	-0.5	-1.1	0.5	-0.7	0.9	-0.5	0.5	-0.5
Unable to work because of sickness or disability	0.3	0.4	0.9	0.6	0.5	1.0	-0.7	0.4	-0.6	0.8	0.8	0.6	-0.2
Commuting to job workplace: Cycle	0.2	0.3	1.5	-0.6	0.0	0.7	1.2	0.3	-0.0	0.0	-0.1	0.1	0.3
Myopia	2.3	3.3	7.0	-0.5	2.0	-2.6	-2.0	1.6	-2.2	1.8	-0.8	2.1	-1.1
Vascular/heart problems diagnosed by doctor	0.4	1.0	4.0	1.2	0.7	1.0	-0.8	0.8	-0.5	1.2	0.4	0.1	-2.0
Cholesterol lowering medication	0.2	0.3	0.8	0.0	0.6	0.1	0.5	0.6	-0.8	0.6	-0.3	0.9	0.5
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	2.3	-1.1	-1.5	0.3	1.0	-1.4	1.5	-1.5	-0.2	-1.2	1.2
Pain experienced in last month	0.8	1.4	4.8	0.9	1.2	-0.8	-0.8	1.2	-0.9	0.9	-1.5	0.4	-2.2
Supplements: Calcium	0.4	0.4	1.7	-1.2	-0.3	1.3	-0.0	-0.3	0.3	-0.5	-0.2	-0.4	-0.4
Basal cell carcinoma (self-reported)	1.8	2.2	10.6	-0.8	1.0	-0.5	-2.5	0.6	-0.7	1.2	-0.9	-0.0	-3.2
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.8	1.1	-0.0	1.7	-0.6	-0.0	0.0	0.4	1.3	-0.2	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.4	0.2	-0.6	1.6	0.4	-0.5	0.6	-0.1	0.9	-0.6	0.1
Heart disease (siblings)	1.0	1.2	7.3	-0.3	0.2	0.3	-2.7	-0.1	-0.1	0.4	-0.7	-0.4	-1.8
Alcohol drinker status: Previous	0.4	0.4	1.7	-0.7	-0.3	-1.3	-0.2	-0.4	-0.0	-0.7	-1.1	0.0	0.6
Pack years of smoking	1.2	1.7	4.4	0.5	1.5	-0.2	-1.9	1.2	-1.3	2.1	1.1	1.2	-0.7
Impedance of whole body	0.5	2.5	5.9	1.5	1.8	0.3	-0.1	1.9	-2.0	1.5	1.3	2.4	1.2
Leg fat mass (left)	0.4	1.7	5.2	-1.3	-1.4	-0.4	1.6	-1.3	1.2	-1.1	0.2	-0.7	2.3
Arm predicted mass (left)	2.1	10.6	21.3	-3.3	-4.3	-0.1	1.6	-4.0	4.5	-3.4	-2.0	-4.6	0.6