Hub : Genes

IAH1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0750 0.0260 7.8e-05 0.032 0.025 0.020 0.025 0.021 8.5e-05 4.8e-04 1.6e-03 3.9e-04 1.2e-03
2 GTEx Cells Transformed fibroblasts 0.0910 0.0390 1.7e-03 0.095 NA 0.070 NA 0.073 1.4e-07 NA 5.7e-06 NA 3.7e-06
3 GTEx Esophagus Mucosa 0.1230 0.0470 3.3e-03 0.004 NA -0.002 NA 0.007 1.6e-01 NA 5.0e-01 NA 1.1e-01
4 GTEx Pancreas 0.2200 0.0750 3.2e-04 0.135 NA 0.089 NA 0.131 2.6e-06 NA 1.4e-04 NA 3.8e-06
5 GTEx Testis 0.3000 0.0840 4.6e-05 0.074 NA 0.076 NA 0.094 3.4e-04 NA 2.9e-04 NA 5.8e-05
6 NTR Blood 0.0306 0.0084 2.0e-08 0.034 0.027 0.033 0.034 0.036 2.8e-11 2.7e-09 7.1e-11 3.6e-11 8.8e-12
7 ROSMAP Brain Pre-frontal Cortex 0.0793 0.0226 2.0e-07 0.070 0.059 0.063 0.061 0.065 2.2e-09 4.1e-08 1.7e-08 2.3e-08 8.8e-09
8 YFS Blood 0.0662 0.0177 6.8e-09 0.010 0.025 0.039 0.023 0.025 2.2e-04 7.3e-09 9.2e-13 3.8e-08 7.4e-09
9 TCGA Kidney Renal Clear Cell Carcinoma 0.0257 0.0192 3.3e-03 0.015 0.021 0.017 NA 0.017 7.2e-03 1.7e-03 4.5e-03 NA 4.5e-03
10 TCGA Thyroid Carcinoma 0.0910 0.0510 4.4e-03 0.031 0.030 0.028 NA 0.027 5.0e-04 5.4e-04 8.6e-04 NA 1.0e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.5 0.8 2.2 -1.4 -0.2 0.7 -0.6 -0.2 0.3 -0.6 -1.5 -0.7 -1.4
Bipolar Disorder or Schizophrenia 0.2 0.6 2.0 -1.4 -0.2 0.7 -0.5 -0.3 0.3 -0.7 -1.0 -0.7 -1.1
Depressed Affect (Nagel 2018) 0.8 1.6 3.2 -0.7 -1.4 -1.6 0.3 -1.4 1.3 -1.4 -1.8 -1.1 0.8
Depression (Nagel 2018) 0.1 0.1 0.4 0.6 0.1 -0.2 0.0 0.1 -0.1 0.6 -0.3 0.2 0.5
Intelligence (Savage-Jansen 2018) 0.4 1.1 5.0 0.2 0.1 -2.2 -1.1 0.0 0.1 0.5 -1.4 -0.5 -1.4
Neuroticism (Nagel 2018) 0.3 0.6 2.0 -0.3 -0.6 -1.3 -0.1 -0.7 0.7 -0.8 -1.4 -0.7 -0.0
Schizophrenia (2018) 0.1 0.1 0.5 -0.7 -0.1 0.4 -0.1 -0.3 0.1 -0.4 -0.2 -0.4 -0.2
Schizophrenia vs Biploar Disorder 0.1 0.1 0.2 0.0 -0.1 0.3 0.4 0.1 0.1 0.4 0.5 -0.1 0.2
Worry (Nagel 2018) 0.3 0.6 1.7 -0.2 0.4 -1.2 -1.3 0.3 -0.4 -0.2 -1.1 0.2 -0.9
Alzheimer’s Disease (in mother) 0.5 0.6 3.1 -0.5 0.2 -1.4 -1.8 -0.0 -0.3 0.4 0.4 0.2 -0.4
Alzheimer’s Disease (in father) 0.4 0.5 1.7 -0.4 -0.6 -1.3 -0.2 -0.7 0.6 -0.5 -0.5 -0.5 0.9
Alzheimer’s Disease (including proxy) 0.5 0.7 4.0 -0.1 0.0 -1.5 -2.0 -0.2 -0.2 0.4 0.3 0.2 0.0
Crohns Disease (2017) 0.4 0.8 2.3 -0.7 -0.8 -0.3 1.3 -0.4 0.7 -1.0 1.0 -0.3 1.5
Irritable Bowel Disease (IBD) 2.6 6.1 12.9 -2.2 -2.8 -0.1 3.4 -2.3 2.6 -3.1 0.1 -1.7 3.6
Ulcerative Colitis (UC) 3.9 7.3 15.9 -2.4 -2.9 0.2 3.9 -2.4 2.8 -3.3 -0.3 -1.8 4.0
Major Depression (MDD) 1.0 1.2 3.2 1.8 0.6 1.6 -1.5 0.5 -0.4 0.9 1.0 -0.0 -1.3
Reaction Time 0.9 1.8 3.8 0.1 1.6 2.0 0.4 1.8 -1.6 1.0 1.0 1.8 -0.4
Verbal and Numeric Reasoning (VNR) 1.1 2.7 14.5 0.8 0.8 -3.8 -2.1 0.4 -1.0 1.0 -1.7 0.5 -1.4
Breast Cancer 0.1 0.2 0.9 0.3 -0.2 0.8 -0.7 -0.3 -0.0 0.2 -0.1 -0.3 -0.9
Ovarian Cancer 0.4 0.5 1.9 0.0 -0.0 1.4 -1.0 0.2 0.0 0.4 0.5 -0.4 -1.1
Prostate Cancer 1.0 1.4 6.2 0.8 -0.1 1.4 2.5 0.2 0.2 -0.2 1.7 0.2 1.4
Age at First Birth 1.7 2.5 7.3 2.0 1.1 1.4 1.5 1.3 -1.0 0.8 2.7 1.6 1.7
Bipolar Disorder (2011) 0.3 0.3 1.0 -0.4 -0.3 -0.0 0.2 -0.5 0.3 -0.9 -1.0 -0.5 -0.4
Body Mass Index (BMI) (2010) 3.1 4.3 11.1 -3.3 -2.0 -2.3 0.7 -2.0 1.7 -2.0 -2.8 -1.8 0.2
Coronary Artery Disease (CAD) 2.6 3.2 7.9 -1.2 -2.2 1.2 -0.1 -2.2 2.3 -1.4 -1.4 -2.8 -1.4
Crohns Disease (2012) 0.3 0.4 1.4 -0.7 -0.5 -0.1 1.2 -0.3 0.5 -0.4 0.8 -0.4 0.8
Mean Putamen Volume 0.8 1.0 3.8 -1.2 0.0 -2.0 -0.7 -0.2 0.1 -0.1 -1.5 -0.4 -1.2
Fasting Glucose 0.8 1.0 4.0 -0.2 -0.5 0.8 2.0 -0.5 0.6 -0.3 0.5 -0.1 2.0
HbA1C 0.7 0.8 3.7 -1.9 0.0 -1.2 -0.3 0.0 -0.1 -0.1 -1.4 -0.2 -0.7
HDL Cholesterol 1.0 1.6 3.0 1.4 1.6 0.2 0.6 1.7 -1.6 1.6 0.5 1.6 0.7
LDL Cholesterol 1.0 1.6 2.8 -1.4 -1.5 0.5 0.5 -1.5 1.7 -1.7 -0.4 -1.6 0.3
Lupus 0.3 0.5 1.7 -0.7 -0.2 -0.6 -1.0 -0.5 0.1 -0.4 -1.3 -0.4 -1.0
Neuroticism (2016) 0.3 0.5 1.5 -0.7 -0.5 -1.2 0.2 -0.6 0.4 -0.5 -1.1 -0.6 0.1
Primary Biliary Cirrhosis 0.9 1.3 2.7 1.0 1.5 0.9 -0.4 1.6 -1.3 1.2 0.7 1.2 -0.9
Rheumatoid Arthritis 2.2 3.1 8.5 2.0 0.7 2.1 2.0 1.2 -0.8 0.9 2.9 1.4 2.1
Schizophrenia (2014) 0.2 0.4 1.3 -0.9 -0.0 0.7 -0.7 -0.1 0.1 -0.2 -0.9 -0.5 -1.1
Triglycerides 3.4 5.6 9.5 -2.5 -2.9 -1.1 0.2 -3.1 2.8 -3.0 -2.4 -2.8 0.1
Type 2 Diabetes (T2D) (2012) 1.3 1.5 2.9 -1.5 -1.0 -1.6 1.6 -0.7 0.9 -0.7 -1.7 -0.7 1.1
Ulcerative Colitis 4.0 5.8 9.3 -2.7 -2.9 0.1 2.3 -2.5 2.8 -3.0 -0.7 -2.2 2.9
Blood Eosinophil Count 0.4 2.7 5.2 -1.1 -2.3 0.9 0.8 -2.3 2.1 -2.2 -0.3 -2.0 0.9
Blood Platelet Count 0.1 1.7 3.5 0.7 1.4 0.7 -1.7 1.2 -1.4 1.1 1.4 1.0 -1.9
Blood Red Count 0.1 0.5 1.6 0.3 0.1 -0.8 1.1 0.2 -0.1 0.5 -0.8 0.5 1.3
Blood White Count 0.2 1.5 4.7 1.2 0.7 -0.2 0.0 0.8 -1.0 1.0 2.2 1.5 1.7
Heel T-Score 0.2 1.3 3.4 1.9 1.2 0.5 -1.6 0.8 -0.7 1.2 1.2 1.0 -0.2
BMI 0.2 1.0 4.1 -1.0 -0.7 -1.1 1.4 -0.7 0.5 -0.5 -0.5 -0.0 2.0
Height 2.6 49.3 94.9 -8.4 -8.9 0.4 1.9 -8.9 9.2 -7.7 -4.7 -9.7 0.3
Waist Hip Ratio (WHR) 3.8 17.2 29.2 -4.2 -5.2 -0.3 0.3 -5.3 5.0 -5.3 -3.9 -5.4 0.8
Systolic Blood Pressure 0.2 1.1 4.1 -0.2 0.6 -2.0 0.9 0.4 -0.7 -0.2 0.1 1.2 2.0
Smoking Status 0.2 0.6 3.8 -0.2 -0.3 2.0 -0.6 -0.3 0.3 0.3 0.6 -0.5 -0.6
Allergy or Eczema 1.2 3.1 5.0 -2.1 -2.2 -1.7 0.3 -2.2 1.9 -1.8 -1.6 -2.0 0.3
Cardiovascular Disease 0.4 1.4 6.7 -1.0 -0.6 -1.6 1.3 -0.6 0.4 -0.9 0.2 0.2 2.6
Hypothyroidism (self reported) 1.3 3.0 7.0 2.6 1.8 0.2 -1.2 1.8 -2.2 1.9 1.6 1.9 -0.4
Respiratory disease 0.5 1.1 2.5 -0.9 -1.3 1.0 0.4 -1.2 1.3 -1.6 -0.4 -1.4 -0.3
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.9 1.4 -0.5 0.1 -0.2 -0.5 0.3 0.2 1.1 -0.1 1.1
Lung FEV1/FVC ratio 0.3 1.5 5.2 0.1 1.0 -0.6 -1.2 0.9 -0.8 2.3 -1.6 0.6 -1.6
Lung FVC 0.4 1.8 3.1 1.7 1.6 1.0 0.3 1.8 -1.4 1.7 1.1 1.5 -0.3
Neuroticism 0.1 0.3 1.3 -0.2 -0.2 -1.1 -0.5 -0.2 0.4 -0.3 -0.7 -0.4 -0.2
Chronotype (morning person) 0.8 1.7 3.1 -1.5 -1.7 -0.5 0.7 -1.8 1.4 -1.7 -0.5 -1.3 1.4
Hair Pigment 0.1 2.1 4.0 0.9 1.9 0.1 -1.9 1.8 -2.0 1.3 0.6 1.8 -0.9
Tanning 0.1 1.2 2.3 1.0 1.2 -0.3 -1.5 1.0 -1.4 1.5 0.7 1.1 -0.9
Hand grip strength (left) 0.5 1.4 5.8 1.4 0.2 2.4 0.4 0.4 0.1 0.9 1.6 -0.6 -1.4
Number of treatments/medications taken 1.0 1.8 4.2 -2.0 -1.4 -0.4 -0.1 -1.6 1.2 -1.5 -1.9 -1.4 0.4
Average weekly spirits intake 1.2 1.5 6.8 -0.3 0.8 -0.2 -2.6 0.5 -0.8 1.6 0.7 0.3 -1.9
Sensitivity / hurt feelings 0.1 0.1 0.7 -0.5 0.2 0.1 -0.3 0.2 -0.0 0.4 -0.0 -0.1 -0.8
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.5 1.2 1.0 0.0 -0.5 1.0 -1.0 0.9 0.5 1.0 -0.1
Hearing difficulty/problems: Yes 1.5 2.3 4.4 -1.4 -1.7 -1.1 0.6 -1.9 1.7 -2.1 -1.1 -1.3 1.7
Relative age of first facial hair 0.1 0.2 0.6 -0.1 0.1 -0.6 -0.8 -0.2 -0.3 -0.0 -0.3 0.1 -0.7
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.1 -1.1 -0.9 0.5 -0.2 -0.9 0.6 -0.4 0.1 -0.9 -0.3
Ever used hormone-replacement therapy (HRT) 0.6 0.8 4.9 -0.9 -0.6 2.2 -0.1 -0.3 0.7 -0.3 -0.4 -0.6 -0.5
Ever had hysterectomy (womb removed) 2.2 2.5 5.4 -0.6 -2.2 0.4 -0.2 -2.1 2.1 -1.9 -1.4 -2.3 -0.3
Systolic blood pressure, automated reading 0.3 0.8 2.4 -0.3 0.9 -1.5 -0.5 0.7 -1.2 0.4 0.5 1.3 0.8
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 2.8 -0.1 -1.3 -0.1 0.9 -1.2 1.1 -1.3 0.2 -0.7 1.7
Angina 0.2 0.2 1.1 -0.6 -0.3 1.0 -0.6 -0.2 0.1 -0.1 0.1 -0.3 -0.3
Medication for hormone replacement therapy 0.9 1.0 3.8 -1.0 -1.1 -0.5 0.9 -0.9 0.9 -1.2 -0.0 -0.2 1.9
Vitamin and mineral supplements 0.6 0.9 4.0 0.1 -0.5 -0.6 1.6 -0.3 0.2 -0.3 1.0 0.2 2.0
Supplements: Zinc 0.8 0.9 5.6 0.9 0.1 2.4 -0.3 0.0 0.0 0.5 1.2 -0.3 -0.6
Medication: Co-codamol 0.9 1.1 2.7 -1.7 -0.9 -1.3 0.3 -1.1 0.8 -1.1 -0.5 -0.5 1.3
Medication: Metformin 0.6 0.8 1.9 0.3 -1.3 -1.1 -0.2 -1.4 1.0 -0.8 0.5 -0.9 1.0
Diabetes (father) 0.3 0.4 1.2 -0.4 -0.6 -1.1 1.0 -0.4 0.5 -0.3 -0.3 -0.4 0.5
Diabetes (mother) 1.0 1.3 3.1 1.8 1.5 0.4 0.0 1.5 -1.3 1.3 0.1 1.3 -0.4
Severe depression (siblings) 0.1 0.1 0.3 -0.1 0.1 0.4 0.6 0.2 0.0 0.2 -0.2 0.1 0.0
Pack years adult smoking proportion 1.2 1.8 4.8 0.7 1.6 0.0 -1.7 1.4 -1.4 2.2 1.1 1.3 -0.7
Impedance of leg (right) 0.6 2.8 5.5 2.1 2.0 0.8 -0.3 2.0 -2.1 1.9 1.2 2.3 0.5
Leg fat-free mass (left) 1.3 7.0 13.7 -2.9 -3.5 -0.3 1.3 -3.3 3.6 -2.7 -1.3 -3.7 0.5
Trunk fat percentage 0.4 1.5 8.9 -0.9 -0.5 -0.8 1.6 -0.5 0.1 -0.5 0.7 0.6 3.0
Hand grip strength (right) 0.3 0.8 3.5 0.8 -0.3 1.9 1.1 -0.1 0.5 0.3 1.4 -0.6 -0.3
Townsend deprivation index at recruitment 0.1 0.1 0.4 -0.6 0.3 -0.0 -0.1 0.1 -0.3 0.3 -0.5 0.1 -0.4
Current tobacco smoking 0.3 0.6 2.2 1.1 0.5 1.5 -0.7 0.5 -0.4 0.9 0.2 0.2 -0.6
Average weekly fortified wine intake 0.1 0.1 0.6 0.4 0.1 -0.8 -0.3 0.1 -0.2 0.3 0.4 0.0 0.1
Maternal smoking around birth 0.2 0.2 0.7 -0.3 0.4 -0.8 -0.6 0.1 -0.5 0.1 -0.8 0.3 -0.3
Fed-up feelings 0.7 1.2 4.8 -0.4 -0.8 -1.4 1.5 -0.7 0.7 -0.9 -0.6 -0.0 2.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 3.0 1.7 1.1 -0.3 -0.2 1.1 -1.4 0.9 0.9 1.5 0.9
Relative age voice broke 0.1 0.2 0.9 -0.4 0.0 -0.7 -1.0 -0.3 -0.4 -0.2 -0.1 0.3 0.1
Taking other prescription medications 0.4 0.6 1.6 -1.1 -0.6 1.3 -0.6 -0.7 0.5 -0.5 0.1 -0.9 -1.0
Age when periods started (menarche) 0.1 0.2 0.8 0.9 -0.1 0.5 -0.8 -0.0 0.0 -0.2 0.0 -0.2 -0.6
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.5 1.2 0.7 0.6 -0.7 0.8 -1.0 0.8 1.0 1.0 0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.6 1.2 0.3 1.1 -1.3 0.2 -0.3 0.5 1.0 0.1 -0.3
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 2.3 -0.6 0.6 -0.3 -1.5 0.4 -0.4 0.4 -0.1 0.1 -1.4
Qualifications: CSEs or equivalent 0.4 0.5 2.7 -0.5 -0.2 0.8 0.6 -0.2 0.0 -0.1 1.6 0.1 0.9
Serious illness, injury or assault to yourself 0.3 0.4 1.6 0.2 -0.3 0.9 -0.6 -0.2 0.2 0.3 1.3 -0.4 -0.7
High blood pressure 0.6 1.7 7.5 -1.2 -1.0 -1.2 1.3 -1.1 0.8 -1.5 -0.2 -0.3 2.7
Hayfever, allergic rhinitis or eczema 0.5 1.0 1.5 -1.2 -1.2 -1.1 0.5 -1.2 1.1 -1.0 -0.7 -1.1 0.4
Multivitamins +/- minerals 0.7 0.9 4.9 0.4 0.5 0.6 -1.7 0.3 -0.3 0.4 -0.8 -0.2 -2.2
Stomach or abdominal pain in last month 0.4 0.5 0.9 -0.8 -0.9 0.4 -0.4 -0.9 0.9 -0.9 0.4 -0.8 0.3
Supplements: Glucosamine 1.2 1.6 5.3 0.6 1.0 1.6 -0.5 1.2 -1.0 1.5 2.3 0.8 -1.2
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 3.0 -0.9 -1.6 0.1 -0.3 -1.7 1.5 -1.4 -0.2 -1.7 -0.0
Medication: Atenolol 0.4 0.5 1.8 -1.0 -0.5 0.2 0.8 -0.3 0.3 -0.8 0.1 -0.1 1.3
Medication: Levothyroxine sodium 0.4 0.7 2.5 1.0 0.7 -0.5 -1.6 0.5 -1.1 0.8 0.2 0.8 -0.4
Sitting height 0.6 4.4 10.7 -1.3 -3.0 0.9 1.4 -2.7 3.3 -1.4 -0.7 -3.3 0.4
Chronic bronchitis/emphysema (father) 1.1 1.2 3.5 0.1 1.4 -0.4 0.9 1.5 -1.6 0.8 -0.7 1.9 0.5
High blood pressure (mother) 1.1 1.6 2.7 1.5 1.5 -0.5 -0.9 1.5 -1.6 1.5 0.2 1.4 -0.9
Body mass index (BMI) 0.1 0.6 2.0 -0.9 -0.7 -0.9 0.9 -0.7 0.5 -0.5 -0.0 -0.2 1.4
Impedance of leg (left) 0.3 1.5 3.6 1.3 1.5 0.4 -0.1 1.5 -1.5 1.2 0.8 1.9 0.9
Leg predicted mass (left) 1.3 6.7 13.3 -2.9 -3.4 -0.3 1.2 -3.3 3.6 -2.7 -1.3 -3.6 0.5
Trunk fat mass 0.6 2.6 8.1 -1.8 -1.7 -0.6 2.0 -1.6 1.5 -1.4 0.1 -0.9 2.9
Waist circumference 0.9 3.4 6.0 -2.4 -2.2 -1.0 1.2 -2.2 2.0 -2.0 -1.4 -1.8 1.7
Number of incorrect matches in round 0.2 0.3 1.8 -1.4 0.1 -0.7 0.1 -0.1 -0.3 -0.5 -0.7 0.3 0.3
Past tobacco smoking 0.4 0.7 2.4 1.6 1.1 0.1 -0.2 1.0 -0.9 0.8 0.2 0.9 -0.3
Alcohol usually taken with meals 0.2 0.4 1.7 1.3 0.2 0.5 0.2 0.4 -0.2 0.6 1.1 0.0 -0.2
Nervous feelings 0.6 1.2 2.1 -0.2 1.4 -1.2 -1.4 1.1 -1.4 0.9 -0.2 1.2 -0.8
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.8 0.9 0.1 -0.1 0.6 0.3 -0.2 -0.0 -0.2 0.3 0.4
Hearing difficulty/problems with background noise 1.8 2.9 6.6 -1.6 -1.6 -1.2 1.6 -1.6 1.8 -2.3 -1.0 -1.1 2.6
Hair/balding pattern: Pattern 2 1.4 1.8 3.2 0.6 1.8 -1.3 -0.7 1.6 -1.7 1.3 -1.0 1.6 -0.9
Had menopause 1.2 1.5 4.4 0.6 1.4 -0.0 -0.7 1.4 -1.5 2.1 0.9 1.4 -0.9
Had other major operations 0.6 0.7 3.6 0.7 -0.0 0.3 -1.9 0.0 -0.0 0.7 0.3 -0.3 -1.4
Forced vital capacity (FVC) 0.3 1.3 4.2 0.4 -1.0 2.0 1.1 -0.6 1.6 -0.3 0.6 -1.6 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.8 0.4 -0.6 0.4 0.1 -0.7 0.5 -0.5 0.6 -0.3 1.3
Ever unenthusiastic/disinterested for a whole week 1.0 1.2 3.0 -0.3 -1.4 1.2 -0.3 -1.3 1.5 -0.9 -0.6 -1.7 -0.5
Qualifications: None of the above 0.8 1.7 4.8 1.5 1.2 2.2 0.4 1.2 -1.2 0.9 1.4 1.5 0.4
Financial difficulties in last 2 years 1.3 1.7 3.1 -0.7 -1.6 -0.5 -0.3 -1.8 1.7 -1.7 -1.3 -1.7 -0.1
Mouth/teeth dental problems 0.2 0.2 1.4 -0.0 -0.1 -0.1 -1.2 -0.1 0.0 -0.0 0.1 -0.3 -0.9
Heart attack 0.3 0.4 1.8 0.7 -0.2 1.3 -0.3 -0.2 0.1 0.2 1.0 -0.2 0.0
Allergy 0.4 1.0 1.6 1.3 1.3 0.4 -1.0 1.1 -1.2 1.0 0.5 1.0 -0.5
Pain all over the body in last month 0.4 0.5 1.7 0.2 0.2 -1.3 0.5 0.5 -0.3 -0.2 -0.0 0.8 1.3
Diabetes (self-reported) 0.6 0.9 2.1 0.0 -1.4 -0.3 -0.2 -1.5 1.2 -1.0 0.3 -0.9 1.2
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 4.4 -0.9 -0.6 -2.1 0.0 -0.7 0.6 -1.2 -1.9 -0.5 -0.1
Medication: Ramipril 0.3 0.4 2.2 0.2 0.5 -1.5 0.6 0.4 -0.3 0.2 -0.2 0.6 0.9
Medication: Simvastatin 0.3 0.4 1.1 -0.9 -0.6 0.7 0.9 -0.4 0.4 -0.5 -0.1 -0.3 1.0
Fluid intelligence score 1.4 2.9 6.0 1.6 1.9 -2.4 -1.6 1.7 -2.1 1.8 -0.4 1.9 -0.7
Illnesses of siblings 0.1 0.2 0.5 0.7 -0.3 0.3 0.7 -0.1 0.3 -0.6 -0.1 -0.3 0.1
Neuroticism score 0.3 0.7 1.5 0.6 1.1 -1.2 -0.6 1.0 -0.9 0.7 -0.3 1.0 -0.3
Weight 1.1 5.3 9.1 -2.6 -3.0 -0.3 1.7 -2.9 3.0 -2.3 -0.7 -2.8 1.7
Impedance of arm (right) 0.9 4.2 10.4 1.8 2.6 -0.4 -0.3 2.5 -2.8 2.1 1.4 3.2 1.1
Arm fat percentage (right) 0.4 1.4 7.0 -0.0 0.4 -1.0 1.3 0.4 -0.8 0.4 1.1 1.5 2.6
Trunk fat-free mass 2.0 11.2 25.0 -3.4 -4.4 0.4 1.5 -4.1 4.7 -3.4 -1.9 -5.0 -0.1
Hip circumference 0.2 1.0 3.8 -0.6 0.2 -0.8 1.9 0.3 -0.1 0.5 0.9 0.7 2.0
Time employed in main current job 0.9 1.1 2.3 -0.8 -1.1 1.1 1.5 -1.0 1.1 -1.1 0.6 -0.7 1.1
Alcohol intake versus 10 years previously 0.2 0.3 0.6 0.5 0.6 -0.2 -0.8 0.5 -0.6 0.5 0.3 0.7 0.4
Father’s age at death 1.2 1.6 2.7 0.7 1.5 0.8 1.3 1.6 -1.2 1.6 1.4 1.3 -0.5
Worrier / anxious feelings 0.2 0.4 2.1 0.1 0.7 -1.4 0.1 0.6 -0.5 0.1 -0.6 0.7 0.1
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.7 -0.8 -0.4 -0.4 -0.7 -0.4 0.3 -0.3 0.6 -0.2 0.4
Falls in the last year 0.4 0.5 1.3 -0.2 -1.1 0.1 -0.1 -1.1 0.8 -0.8 -0.4 -1.0 -0.1
Hair/balding pattern: Pattern 3 0.3 0.5 1.0 -0.0 -0.9 -0.2 -0.8 -1.0 0.9 -0.3 0.4 -1.0 -0.3
Number of live births 1.9 2.7 8.1 1.9 1.1 2.9 -1.6 1.4 -0.9 1.6 1.7 0.6 -1.6
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 2.2 0.4 -0.7 1.5 1.1 -0.3 1.2 0.1 0.1 -1.2 -0.4
Pulse rate 0.1 0.1 0.6 -0.2 -0.2 -0.4 0.2 -0.2 -0.0 -0.4 -0.0 0.2 0.8
Happiness 0.1 0.1 0.5 0.1 0.1 -0.0 -0.7 0.1 -0.1 0.1 -0.2 0.0 -0.3
Noisy workplace 1.8 2.2 4.2 -1.3 -2.0 0.5 0.2 -2.1 1.7 -1.9 0.7 -1.6 1.4
Qualifications: A levels/AS levels or equivalent 0.3 0.8 2.0 -0.8 -0.8 -0.6 -0.1 -0.9 1.0 -0.2 -1.4 -1.3 -0.7
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 1.3 -0.0 0.3 0.3 -0.7 0.3 -0.4 0.4 0.3 0.1 -1.1
Mouth/teeth dental problems: Dentures 0.4 0.7 2.2 -0.9 -0.8 0.9 1.5 -0.8 0.7 -0.4 0.0 -0.6 0.7
Asthma 0.7 1.5 3.3 -1.8 -1.2 -1.0 1.0 -1.2 1.2 -1.6 -1.1 -1.1 0.3
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.7 8.5 0.2 -0.1 -2.9 -0.3 -0.6 0.1 -0.5 -2.8 -0.2 0.3
Medication: Cholesterol lowering 1.2 1.8 4.0 -0.9 -1.9 0.3 0.2 -2.0 1.8 -1.6 -0.0 -1.9 0.7
Depression (self-reported) 0.4 0.4 2.7 0.3 0.5 -0.6 0.6 0.5 -0.2 0.2 -1.6 0.4 0.2
Medication: Lansoprazole 1.1 1.3 5.1 -0.6 0.7 -1.2 -2.3 0.5 -1.0 0.7 -1.3 0.6 -1.2
Prospective memory result 1.9 2.3 5.3 -0.8 -2.1 -0.0 0.4 -2.3 1.9 -2.2 -0.5 -1.8 0.9
Lung cancer (father) 1.2 1.4 4.9 -2.1 -0.4 -1.3 1.5 -0.4 0.4 -0.7 -0.1 0.2 2.2
Illnesses of mother 2.6 3.2 5.8 -2.4 -2.0 -0.3 1.7 -1.9 2.0 -2.4 -1.1 -1.7 1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 6.1 0.5 -0.5 2.5 0.7 -0.1 1.0 0.4 0.8 -1.2 -1.1
Pulse wave Arterial Stiffness index 1.0 1.2 2.9 0.1 1.3 -1.7 -0.5 1.2 -1.5 0.8 0.4 1.6 0.1
Impedance of arm (left) 0.7 3.2 8.0 1.4 2.3 -0.2 -0.3 2.2 -2.5 1.8 1.4 2.8 0.9
Arm fat mass (right) 0.3 1.2 4.4 -1.2 -1.0 -0.7 1.5 -0.9 0.8 -0.7 0.2 -0.3 2.1
Trunk predicted mass 2.0 11.7 26.0 -3.4 -4.5 0.3 1.5 -4.2 4.8 -3.4 -2.0 -5.1 -0.1
Standing height 1.5 15.4 32.9 -3.8 -5.2 1.1 1.8 -4.8 5.6 -4.1 -1.5 -5.7 0.7
Length of working week for main job 1.1 1.2 2.4 -0.3 -1.3 0.1 -1.0 -1.4 1.1 -1.1 -1.5 -1.5 -0.9
Exposure to tobacco smoke at home 1.1 1.2 2.7 -0.0 1.2 -1.2 1.2 1.2 -1.2 0.8 -0.6 1.6 1.0
Breastfed as a baby 1.2 1.5 2.7 -1.5 -1.5 -0.8 -1.0 -1.6 1.4 -1.2 0.2 -1.6 -0.2
Tense / ‘highly strung’ 1.0 1.6 5.9 -1.6 -0.3 -2.2 0.1 -0.6 0.3 -1.4 -2.4 -0.2 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 2.4 -0.0 0.5 0.3 -1.2 0.3 -0.5 0.7 -0.5 -0.0 -1.6
Hair/balding pattern: Pattern 4 0.1 0.3 0.6 0.4 0.6 0.7 -0.4 0.6 -0.7 0.3 0.3 0.6 -0.6
Birth weight of first child 6.6 12.0 19.9 -3.2 -4.3 -0.2 2.5 -4.5 4.4 -4.3 -1.9 -4.1 2.5
Peak expiratory flow (PEF) 0.5 1.2 4.0 1.2 0.8 1.0 -0.1 1.2 -0.8 2.0 1.2 0.6 -0.9
Pulse wave reflection index 2.6 3.2 5.1 0.6 2.2 -1.8 -2.1 1.9 -2.3 2.3 -0.1 2.1 -1.1
Ever highly irritable/argumentative for 2 days 0.4 0.5 2.0 -0.3 -0.5 0.7 0.2 -0.4 0.7 -0.2 -1.4 -0.8 -0.5
Loud music exposure frequency 0.3 0.3 0.7 0.2 0.5 0.4 0.9 0.5 -0.3 0.2 0.2 0.6 0.8
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 6.5 -1.6 -0.4 -1.3 -0.1 -0.5 0.7 -0.6 -2.6 -0.9 -1.0
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.9 0.4 0.1 0.7 1.0 0.2 -0.1 0.2 0.7 0.4 0.9
Blood clot in the leg (DVT) 0.3 0.4 2.1 0.2 -0.5 1.4 0.4 -0.4 0.5 -0.0 1.0 -0.5 0.2
Medication: Paracetamol 1.2 2.0 4.2 -1.7 -1.6 -0.8 0.6 -1.7 1.5 -1.7 -0.7 -1.0 2.1
Headache pain in last month 0.2 0.3 0.9 -0.4 -0.2 0.6 -0.9 -0.4 0.1 0.0 0.9 -0.2 -0.5
Medication for cholesterol, blood pressure or diabetes 1.7 2.8 5.8 1.7 1.7 0.3 -2.1 1.8 -1.7 2.0 -0.1 1.2 -2.4
Glaucoma (self-reported) 0.4 0.5 1.7 0.1 0.7 0.3 -1.1 0.6 -0.7 0.4 -0.1 0.4 -1.3
Gout (self-reported) 0.1 0.2 0.5 -0.0 -0.5 -0.4 0.2 -0.5 0.3 -0.7 0.2 -0.3 0.5
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 1.2 1.0 0.0 0.2 -0.8 0.0 -0.4 0.1 1.1 0.2 0.1
Medication: Amlodipine 0.3 0.4 1.7 -0.8 -0.2 0.2 1.3 -0.0 0.4 -0.2 -0.7 -0.1 1.0
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.3 0.3 0.8 0.8 1.1 0.9 -0.6 0.9 0.9 0.7 -0.3
Birth weight 13.9 30.3 68.9 -4.1 -7.5 1.3 0.3 -7.3 7.5 -6.2 -3.1 -8.3 -0.8
Chronic bronchitis/emphysema (mother) 0.8 0.9 1.8 0.7 1.0 0.1 -1.3 0.9 -0.9 0.9 1.2 0.6 -1.1
High blood pressure (siblings) 1.0 1.4 3.5 0.6 1.6 0.4 -0.3 1.6 -1.4 1.9 1.1 1.5 -0.1
Forced vital capacity (FVC), Best measure 0.4 1.5 6.7 0.6 -0.8 2.6 0.7 -0.4 1.2 -0.2 1.4 -1.5 -0.9
Body fat percentage 0.3 1.3 8.4 -0.6 -0.2 -0.8 1.5 -0.2 -0.1 -0.2 0.8 0.8 2.9
Leg fat percentage (right) 0.3 1.1 4.3 0.4 0.7 -0.6 1.1 0.7 -1.0 0.7 0.8 1.5 2.1
Arm fat-free mass (right) 2.1 10.7 22.8 -3.2 -4.3 0.4 1.7 -4.0 4.6 -3.4 -1.6 -4.8 0.4
Exposure to tobacco smoke outside home 0.4 0.6 1.1 0.1 0.9 -0.8 -0.1 0.9 -1.0 0.8 0.4 1.1 -0.4
Comparative body size at age 10 0.2 0.6 1.3 1.0 -0.7 0.9 -0.2 -0.7 0.8 -0.7 0.3 -1.2 -1.0
Number of full brothers 0.4 0.5 1.3 -1.1 -0.7 -0.4 0.3 -0.7 0.7 -0.8 -0.2 -0.4 1.1
Worry too long after embarrassment 2.1 3.5 9.6 1.7 1.9 0.4 -2.7 1.6 -1.5 2.4 0.5 0.9 -3.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.8 -0.4 0.2 -0.6 -0.6 -0.1 -0.0 0.1 -0.9 0.0 -0.5
Wheeze or whistling in the chest in last year 0.1 0.1 0.2 -0.1 0.5 -0.4 -0.3 0.5 -0.4 0.2 0.1 0.5 -0.2
Number of children fathered 2.3 2.6 5.8 -1.4 -2.1 -0.3 0.3 -2.2 1.7 -2.4 -1.1 -1.8 1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.1 -0.3 -0.6 -0.5 -0.5 -0.7 0.6 -0.8 -0.7 -0.8 -1.1
Age at first live birth 0.8 1.3 4.1 1.4 0.2 -0.1 1.9 0.5 -0.5 0.4 1.5 1.0 2.0
Pulse wave peak to peak time 1.4 1.7 3.7 -0.2 -1.6 1.9 0.7 -1.4 1.8 -1.1 -0.5 -1.9 -0.0
Health satisfaction 1.0 1.3 2.3 -1.0 -1.5 -0.3 0.1 -1.4 1.5 -1.4 -1.2 -1.5 0.3
Shortness of breath walking on level ground 2.0 2.4 7.6 -0.3 -1.4 0.1 2.6 -1.1 1.4 -1.8 0.8 -0.7 2.8
Qualifications: College or University degree 0.1 0.2 0.6 0.6 -0.5 0.2 0.4 -0.3 0.7 -0.3 -0.1 -0.8 -0.3
Eye problems/disorders: None of the above 0.9 1.1 3.2 0.4 0.9 -1.6 -0.5 0.8 -1.2 0.8 -1.8 1.0 -0.1
Mouth/teeth dental problems: Loose teeth 0.1 0.2 0.6 -0.5 -0.2 -0.4 0.5 -0.2 0.4 -0.8 -0.2 -0.3 -0.2
Emphysema/chronic bronchitis 0.4 0.4 2.1 -0.3 -0.5 1.4 -0.6 -0.6 0.4 -0.7 0.2 -0.7 -0.4
Medication for pain relief, constipation, heartburn 2.6 4.4 7.6 2.3 2.5 0.9 -0.5 2.7 -2.2 2.8 1.7 1.9 -2.1
Neck or shoulder pain in last month 0.6 0.8 3.4 -1.2 -0.8 0.6 -0.0 -1.0 0.7 -0.2 1.9 -0.7 0.7
Medication: Blood pressure 2.2 3.9 11.0 -1.6 -1.9 -0.2 3.3 -1.7 1.9 -2.2 -0.2 -1.2 3.1
Angina (self-reported) 0.2 0.2 0.6 -0.7 -0.6 0.8 -0.4 -0.5 0.3 -0.4 0.1 -0.4 0.1
Migraine (self-reported) 0.5 0.6 3.7 -0.3 -0.6 0.2 1.0 -0.5 0.5 -0.6 0.5 0.0 1.9
Medication: Ibuprofen 0.7 0.9 3.4 0.5 0.5 -1.9 0.6 0.2 -0.5 0.0 -1.7 0.7 0.8
Medication: Allopurinol 0.4 0.5 1.0 -1.0 -0.5 -1.0 0.2 -0.7 0.3 -0.8 -0.7 -0.2 0.9
Medication: Omeprazole 1.9 2.2 3.5 -1.4 -1.8 0.5 1.4 -1.7 1.9 -1.9 -0.1 -1.5 1.7
Medication: Seretide 50 evohaler 0.6 0.7 1.6 1.0 0.7 1.2 0.1 0.8 -0.5 1.0 1.2 0.3 -0.5
Mean time to correctly identify matches 0.2 0.4 1.3 -1.1 0.4 1.0 0.3 0.5 -0.5 -0.1 -0.0 0.7 -0.0
Heart disease (mother) 3.4 4.1 11.1 1.9 2.0 0.4 -3.3 1.6 -2.0 2.8 0.6 1.2 -2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 2.2 0.6 1.2 -1.5 -0.5 1.0 -1.2 0.9 -0.5 1.0 -0.8
Whole body fat mass 0.5 1.9 6.6 -1.4 -1.4 -0.6 1.8 -1.4 1.2 -1.1 0.2 -0.7 2.6
Leg fat mass (right) 0.3 1.3 4.6 -1.0 -1.2 -0.4 1.5 -1.1 1.0 -0.8 0.3 -0.6 2.1
Arm predicted mass (right) 2.2 11.1 23.2 -3.3 -4.4 0.5 1.8 -4.1 4.7 -3.5 -1.5 -4.8 0.5
Pulse rate, automated reading 1.7 5.6 15.0 1.0 3.0 -1.7 0.7 3.0 -3.1 2.1 1.1 3.9 1.9
Alcohol intake frequency. 0.4 0.8 1.9 0.9 0.9 0.5 1.0 0.9 -1.1 0.7 0.5 1.4 1.1
Comparative height size at age 10 2.5 13.7 27.2 -3.0 -5.0 1.4 2.1 -4.6 5.2 -4.3 -1.1 -5.1 1.6
Number of full sisters 1.5 1.9 4.4 -1.3 -1.7 0.9 -0.4 -1.6 1.8 -1.5 -0.5 -2.1 -0.8
Suffer from ‘nerves’ 1.1 1.7 4.1 0.9 1.4 0.5 -1.5 1.4 -1.5 1.4 0.2 1.1 -2.0
Overall health rating 0.2 0.5 2.4 -0.3 -0.8 -0.1 0.0 -0.8 0.5 -0.6 0.7 -0.2 1.6
Chest pain or discomfort 0.8 1.1 2.9 0.8 1.1 -0.1 -1.5 0.9 -1.0 1.1 -0.6 0.6 -1.7
Had major operations 1.2 1.5 3.3 -1.8 -1.5 0.3 -0.8 -1.4 1.5 -0.7 -0.5 -1.8 -0.3
Age at last live birth 0.9 1.3 3.6 1.2 0.2 0.8 1.9 0.6 -0.4 0.1 1.6 1.0 1.7
Family relationship satisfaction 0.7 0.9 2.6 -0.4 0.6 -0.7 -1.6 0.5 -0.7 0.7 -1.3 0.3 -1.4
Leg pain on walking 0.9 1.1 2.1 -1.4 -1.2 1.2 0.5 -1.0 1.3 -1.1 0.5 -1.2 0.5
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 1.7 -0.3 0.3 -0.2 -0.1 0.3 -0.5 0.2 -1.3 0.3 -0.1
Commuting to job workplace: Car/motor vehicle 0.8 1.0 3.2 1.0 0.9 1.8 0.9 1.3 -0.6 0.8 0.8 0.7 -0.5
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.6 0.3 0.5 0.7 0.9 0.6 -0.5 0.4 1.3 0.6 0.5
Medication: Aspirin 1.1 1.5 2.9 -1.3 -1.5 1.1 -0.2 -1.6 1.4 -1.5 0.1 -1.7 -0.1
Supplements: Vitamin C 0.5 0.5 2.5 -0.7 -0.2 1.1 -0.8 -0.1 0.4 -0.1 0.0 -0.7 -1.6
Knee pain experienced in last month 0.2 0.3 1.3 -0.6 -0.3 0.7 -0.8 -0.5 0.2 -0.2 1.1 -0.3 0.1
Hypertension (Self-reported) 0.4 1.0 5.6 -0.6 -0.4 -1.1 1.3 -0.4 0.3 -0.8 0.1 0.2 2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.3 -0.3 -0.1 0.4 0.2 -0.1 0.1 -0.5 -0.6 -0.1 0.1
Illnesses of father: Heart disease 2.6 3.6 10.5 1.7 2.1 -0.6 -3.2 1.8 -1.8 2.1 0.3 1.4 -2.2
Illnesses of siblings: Diabetes 0.2 0.3 0.6 -0.4 -0.8 -0.1 0.2 -0.7 0.6 -0.7 -0.5 -0.7 -0.1
Smoking status: Previous 0.4 0.6 2.8 -1.7 -0.7 -1.2 -0.0 -0.7 0.4 -0.6 -0.4 -0.4 0.3
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.1 5.5 -1.0 -1.9 0.4 1.1 -1.7 2.4 -1.0 -0.5 -2.3 -0.2
Whole body fat-free mass 1.9 10.7 22.8 -3.4 -4.3 0.0 1.4 -4.1 4.5 -3.3 -1.9 -4.8 0.1
Leg fat-free mass (right) 1.5 7.9 15.4 -3.2 -3.6 -0.4 1.3 -3.5 3.9 -3.0 -1.4 -3.9 0.5
Arm fat percentage (left) 0.3 1.3 6.7 -0.3 0.3 -1.1 1.3 0.2 -0.6 0.2 1.0 1.2 2.6
Average weekly red wine intake 0.5 0.7 2.7 0.6 -0.6 -1.7 -0.5 -0.8 0.6 -0.3 -1.2 -0.7 -0.1
Handedness (chirality/laterality): Left-handed 3.1 3.7 7.7 1.6 2.6 0.0 0.3 2.8 -2.5 2.4 1.0 2.7 -0.3
Mood swings 0.3 0.5 1.8 0.7 0.6 -0.2 0.8 0.6 -0.6 0.0 -0.0 1.1 1.3
Loneliness, isolation 1.0 1.4 2.8 -1.2 -1.3 -0.8 -0.3 -1.5 1.4 -1.2 -1.7 -1.5 0.4
Long-standing illness, disability or infirmity 1.1 1.6 3.8 -1.7 -1.5 2.0 0.3 -1.5 1.2 -1.1 -0.1 -1.4 -0.2
Ever had bowel cancer screening 0.2 0.3 1.0 -0.9 0.2 -0.5 -0.5 0.2 -0.3 -0.2 -1.0 0.2 -0.5
Diabetes diagnosed by doctor 0.4 0.7 2.0 0.4 -1.1 -0.2 0.1 -1.1 1.0 -0.7 0.4 -0.7 1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 1.7 0.7 0.1 1.3 0.4 0.4 0.2 -0.0 -0.0 -0.1 -0.8
Friendships satisfaction 0.3 0.4 1.5 -1.1 0.1 0.4 1.2 0.2 0.1 0.1 -0.5 0.2 0.7
Qualifications: nursing, teaching 0.3 0.4 1.8 0.6 0.2 -0.3 -1.4 0.0 -0.3 0.7 1.1 0.2 -0.5
Commuting to job workplace: Walk 0.7 0.7 4.7 -0.5 0.0 -2.2 -0.8 -0.2 -0.3 -0.2 -0.9 0.4 0.6
Eye problems/disorders: Cataract 1.0 1.1 3.8 -0.4 -0.7 0.0 1.8 -0.5 0.7 -0.2 1.9 -0.2 1.7
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 1.2 0.1 -0.3 -0.8 0.1 -0.3 0.2 -0.5 -0.1 0.1 1.1
Medication for cholesterol 0.2 0.4 0.9 0.7 -0.3 0.8 0.1 -0.4 0.7 -0.3 -0.2 -0.9 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 6.9 8.2 13.0 -2.3 -3.6 -0.1 2.6 -3.5 3.5 -3.5 -2.1 -3.1 2.4
Back pain experienced in last month 0.3 0.4 1.7 0.8 0.2 1.3 0.5 0.3 -0.3 0.4 0.8 0.3 0.4
Mineral and other dietary supplements 1.0 1.3 4.2 -1.1 -0.6 -2.0 0.8 -0.8 0.7 -1.0 -1.6 -0.4 1.4
Breast cancer (self-reported) 5.3 6.3 10.3 2.6 3.0 1.6 -2.0 3.1 -2.7 3.2 1.7 2.4 -2.1
Asthma (self-reported) 0.9 1.7 3.3 -1.8 -1.4 -1.0 0.8 -1.4 1.3 -1.7 -1.4 -1.3 0.1
Osteoporosis (self-reported) 0.8 1.0 2.7 -0.3 -1.0 1.1 -0.3 -1.0 1.1 -0.2 -0.5 -1.6 -1.6
Osteoarthritis (self-reported) 0.7 0.9 4.2 -0.8 -0.6 2.0 -0.9 -0.6 0.1 -0.7 1.3 -0.4 -0.2
Medication: Aspirin 1.5 2.0 3.7 -1.7 -1.8 0.3 0.1 -1.9 1.6 -1.9 -0.4 -1.8 0.4
Medication: Gliclazide 0.9 1.0 2.0 -0.3 -1.1 -0.5 -1.4 -1.4 0.8 -0.8 -0.8 -1.4 -1.0
Illnesses of father: None of the above (group 1) 1.1 1.3 1.9 -1.3 -1.4 0.5 1.4 -1.3 1.2 -1.3 -0.4 -1.2 0.9
Smoking status: Current 0.2 0.4 3.2 0.5 -0.2 1.8 -0.1 -0.1 0.3 0.2 0.2 -0.4 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.2 -0.2 -0.2 0.2 0.4 -0.2 0.4 0.3 -0.5 -0.5 -0.4
Whole body water mass 1.8 10.5 22.3 -3.4 -4.2 0.0 1.5 -4.0 4.5 -3.3 -1.8 -4.7 0.2
Leg predicted mass (right) 1.5 7.8 15.4 -3.2 -3.6 -0.4 1.2 -3.5 3.8 -2.9 -1.4 -3.9 0.4
Arm fat mass (left) 0.4 1.4 4.5 -1.4 -1.2 -0.7 1.4 -1.2 1.1 -1.0 0.2 -0.6 2.1
Number of self-reported non-cancer illnesses 1.0 1.8 3.7 -1.9 -1.6 0.4 0.5 -1.7 1.4 -1.8 -0.8 -1.4 0.7
Average weekly champagne plus white wine intake 0.4 0.6 2.9 0.2 -0.3 0.5 1.7 0.0 0.7 -0.5 -1.2 -0.6 -0.3
Miserableness 1.4 2.4 4.3 1.4 2.0 -0.3 -0.8 1.9 -2.1 2.0 1.1 1.8 -1.3
Guilty feelings 0.5 0.7 2.9 1.7 0.9 0.3 0.2 1.3 -0.7 0.5 0.1 0.7 -0.7
Wears glasses or contact lenses 0.5 0.6 1.5 -1.2 -0.3 -1.0 1.0 -0.3 0.1 -0.1 -1.0 0.1 0.9
Ever taken oral contraceptive pill 0.4 0.5 1.9 1.1 0.6 0.7 -0.5 0.6 -0.4 0.5 -0.1 0.1 -1.4
Hearing aid user 0.2 0.2 0.8 -0.2 0.2 -0.4 0.3 0.1 -0.2 -0.0 0.7 0.6 0.9
Mother’s age at death 2.2 2.7 7.0 2.7 1.7 0.9 -1.1 1.7 -1.6 1.9 1.8 1.5 -0.9
Financial situation satisfaction 0.3 0.4 1.6 -0.1 -0.3 0.1 -1.3 -0.4 0.3 -0.0 -1.0 -0.6 -0.8
Tinnitus: Yes, now most or all of the time 0.4 0.5 2.4 0.0 -0.5 0.1 0.9 -0.5 0.6 -0.5 0.3 -0.2 1.5
Commuting to job workplace: Public transport 2.0 2.4 7.5 -1.6 -1.4 -2.7 0.4 -1.7 1.2 -1.6 -1.1 -0.9 1.6
Eye problems/disorders: Glaucoma 0.1 0.1 0.6 -0.3 0.1 0.7 -0.3 -0.0 0.2 -0.1 0.2 -0.3 -0.8
Medication: Blood pressure 1.0 1.9 3.6 0.3 1.7 -1.4 -1.5 1.5 -1.9 1.6 -0.0 1.7 -0.5
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.3 -1.1 -0.3 0.8 -0.7 -0.3 0.1 -0.7 -1.0 -0.4 -0.7
Supplements: Fish oil (including cod liver oil) 1.0 1.3 2.8 1.7 0.8 1.7 -0.6 1.2 -0.9 0.9 1.1 0.8 -1.2
High cholesterol (Self-reported) 0.3 0.6 1.1 -0.8 -0.8 -0.7 0.5 -1.0 0.7 -1.0 -0.6 -0.6 0.9
Medication: Bendroflumethiazide 0.6 0.9 6.0 -1.0 -0.0 -2.5 0.4 -0.1 -0.1 -0.3 -0.8 0.2 1.2
Medication: Paracetamol 0.3 0.5 1.3 -1.0 -0.5 -0.7 -0.2 -0.6 0.4 -0.5 -0.8 -0.2 1.1
Medication: Lisinopril 0.1 0.1 0.4 -0.3 0.1 -0.2 0.6 0.0 -0.2 0.3 -0.3 0.2 0.0
Medication: Atorvastatin 0.4 0.5 1.0 0.1 -0.8 -0.8 0.2 -1.0 0.8 -0.7 -1.0 -0.8 -0.1
Illnesses of father: High blood pressure 1.2 1.5 5.0 2.2 1.1 1.3 0.2 1.2 -0.9 1.1 1.6 1.0 -0.3
Alcohol drinker status: Never 1.0 1.2 6.6 1.2 0.6 2.6 0.7 0.8 -0.4 0.9 1.2 0.6 0.2
Ever smoked 0.3 0.6 1.4 -1.2 -1.0 0.6 0.7 -0.9 0.9 -0.7 0.2 -0.9 0.4
Basal metabolic rate 1.6 8.7 17.7 -3.1 -3.9 -0.0 1.5 -3.7 4.1 -3.0 -1.5 -4.2 0.5
Leg fat percentage (left) 0.3 1.0 5.3 -0.1 0.3 -0.7 1.2 0.3 -0.6 0.3 0.5 1.2 2.3
Arm fat-free mass (left) 1.7 8.6 18.0 -2.8 -3.9 0.2 1.4 -3.7 4.1 -3.0 -1.6 -4.2 0.4
Number of operations (self-reported) 1.2 1.8 4.6 -0.4 -1.5 0.7 -2.1 -1.6 1.4 -0.6 -0.0 -1.9 -1.4
Average weekly beer plus cider intake 0.2 0.3 1.4 0.7 0.4 0.2 0.5 0.3 -0.5 0.0 0.5 0.7 1.2
Irritability 0.7 1.2 3.0 0.1 1.1 -1.7 0.8 1.1 -1.0 0.5 -0.4 1.5 1.4
Risk taking 2.6 3.8 7.0 -1.4 -2.5 1.8 1.5 -2.3 2.7 -2.4 0.0 -2.6 0.4
Ever had prostate specific antigen (PSA) test 0.3 0.3 2.3 -0.8 0.0 -1.5 -0.4 -0.1 -0.1 0.4 -0.3 -0.0 -0.3
Fractured/broken bones in last 5 years 0.3 0.4 1.5 0.9 0.5 -0.4 0.4 0.4 -0.5 0.7 1.2 0.6 0.1
Age started oral contraceptive pill 0.8 1.0 4.5 -0.1 0.3 -1.1 -2.1 -0.0 -0.4 -0.0 -1.1 -0.1 -1.7
Diastolic blood pressure, automated reading 0.2 0.8 2.6 -1.6 -0.7 -1.0 -0.9 -1.0 0.6 -0.5 -0.8 -0.7 0.1
Ever depressed for a whole week 0.3 0.4 1.2 0.2 0.6 -0.5 -1.1 0.5 -0.7 0.9 -0.5 0.5 -0.5
Unable to work because of sickness or disability 0.3 0.4 0.9 0.6 0.5 1.0 -0.7 0.4 -0.6 0.8 0.8 0.6 -0.2
Commuting to job workplace: Cycle 0.2 0.3 1.5 -0.6 0.0 0.7 1.2 0.3 -0.0 0.0 -0.1 0.1 0.3
Myopia 2.3 3.3 7.0 -0.5 2.0 -2.6 -2.0 1.6 -2.2 1.8 -0.8 2.1 -1.1
Vascular/heart problems diagnosed by doctor 0.4 1.0 4.0 1.2 0.7 1.0 -0.8 0.8 -0.5 1.2 0.4 0.1 -2.0
Cholesterol lowering medication 0.2 0.3 0.8 0.0 0.6 0.1 0.5 0.6 -0.8 0.6 -0.3 0.9 0.5
Medication: Omeprazole (e.g. Zanprol) 1.2 1.4 2.3 -1.1 -1.5 0.3 1.0 -1.4 1.5 -1.5 -0.2 -1.2 1.2
Pain experienced in last month 0.8 1.4 4.8 0.9 1.2 -0.8 -0.8 1.2 -0.9 0.9 -1.5 0.4 -2.2
Supplements: Calcium 0.4 0.4 1.7 -1.2 -0.3 1.3 -0.0 -0.3 0.3 -0.5 -0.2 -0.4 -0.4
Basal cell carcinoma (self-reported) 1.8 2.2 10.6 -0.8 1.0 -0.5 -2.5 0.6 -0.7 1.2 -0.9 -0.0 -3.2
Heart attack/myocardial infarction (self-reported) 0.5 0.6 2.8 1.1 -0.0 1.7 -0.6 -0.0 0.0 0.4 1.3 -0.2 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 2.4 0.2 -0.6 1.6 0.4 -0.5 0.6 -0.1 0.9 -0.6 0.1
Heart disease (siblings) 1.0 1.2 7.3 -0.3 0.2 0.3 -2.7 -0.1 -0.1 0.4 -0.7 -0.4 -1.8
Alcohol drinker status: Previous 0.4 0.4 1.7 -0.7 -0.3 -1.3 -0.2 -0.4 -0.0 -0.7 -1.1 0.0 0.6
Pack years of smoking 1.2 1.7 4.4 0.5 1.5 -0.2 -1.9 1.2 -1.3 2.1 1.1 1.2 -0.7
Impedance of whole body 0.5 2.5 5.9 1.5 1.8 0.3 -0.1 1.9 -2.0 1.5 1.3 2.4 1.2
Leg fat mass (left) 0.4 1.7 5.2 -1.3 -1.4 -0.4 1.6 -1.3 1.2 -1.1 0.2 -0.7 2.3
Arm predicted mass (left) 2.1 10.6 21.3 -3.3 -4.3 -0.1 1.6 -4.0 4.5 -3.4 -2.0 -4.6 0.6