Best TWAS P=1.59e-10 · Best GWAS P=4.87e-21 conditioned to 6.85e-13
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | TTLL5 | 0.09 | 0.11 | lasso | 3 | 0.07 | 1.1e-04 | 5.4 | -5.2 | 1.9e-07 | 0.03 | 0.02 | 0.98 | FALSE |
2 | GTEx | Brain Cerebellar Hemisphere | TTLL5 | 0.19 | 0.06 | lasso | 2 | 0.02 | 9.7e-02 | 5.4 | -5.4 | 7.9e-08 | 0.06 | 0.07 | 0.55 | FALSE |
3 | GTEx | Brain Cerebellum | GSTZ1 | 0.36 | 0.00 | enet | 25 | 0.02 | 7.1e-02 | 3.4 | 5.5 | 4.5e-08 | 0.03 | 0.10 | 0.26 | TRUE |
4 | GTEx | Brain Cortex | TTLL5 | 0.23 | 0.09 | lasso | 13 | 0.07 | 5.9e-03 | 4.6 | -5.5 | 3.0e-08 | 0.01 | 0.11 | 0.53 | FALSE |
5 | GTEx | Colon Transverse | NOXRED1 | 0.16 | 0.14 | enet | 19 | 0.17 | 1.2e-08 | 4.8 | 5.4 | 7.7e-08 | 0.08 | 0.02 | 0.97 | FALSE |
6 | NTR | Blood | NPC2 | 0.02 | 0.01 | lasso | 5 | 0.01 | 6.3e-03 | -5.6 | 6.2 | 6.0e-10 | -0.72 | 0.03 | 0.96 | FALSE |
7 | YFS | Blood | NPC2 | 0.09 | 0.06 | enet | 10 | 0.07 | 1.6e-22 | -5.8 | 6.4 | 1.6e-10 | -0.73 | 1.00 | 0.00 | TRUE |
8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TTLL5 | 0.04 | 0.02 | blup | 121 | 0.04 | 1.1e-05 | 4.5 | -5.2 | 2.0e-07 | 0.00 | 0.46 | 0.52 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C14orf148 | 0.10 | 0.08 | blup | 53 | 0.10 | 2.6e-11 | 4.8 | 5.2 | 2.2e-07 | 0.06 | 0.02 | 0.97 | FALSE |
10 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | C14orf148 | 0.11 | 0.02 | blup | 53 | 0.04 | 6.7e-03 | -4.6 | 5.3 | 1.3e-07 | 0.09 | 0.02 | 0.68 | FALSE |
11 | The Cancer Genome Atlas | Lung Adenocarcinoma | TTLL5 | 0.03 | 0.01 | blup | 122 | 0.02 | 3.2e-03 | 4.8 | -5.7 | 1.0e-08 | 0.00 | 0.09 | 0.78 | TRUE |
12 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TTLL5 | 0.02 | 0.01 | blup | 121 | 0.02 | 2.5e-03 | 3.5 | -5.2 | 1.7e-07 | 0.00 | 0.06 | 0.49 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | TMED8 | 0.03 | 0.04 | blup | 72 | 0.03 | 3.3e-04 | 4.7 | -5.2 | 2.2e-07 | -0.03 | 0.02 | 0.75 | FALSE |