Best TWAS P=4.44e-12 · Best GWAS P=8.7e-11 conditioned to 1.2e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | MYO9A | 0.06 | 0.03 | lasso | 2 | 0.01 | 4.7e-02 | 5.5 | -5.5 | 3.0e-08 | -0.12 | 0.35 | 0.13 | FALSE |
| 2 | GTEx | Artery Tibial | MYO9A | 0.07 | 0.08 | enet | 11 | 0.09 | 2.5e-07 | 5.4 | -5.2 | 2.2e-07 | -0.09 | 0.79 | 0.20 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | MYO9A | 0.19 | 0.02 | lasso | 8 | 0.03 | 9.4e-03 | 5.5 | -6.9 | 4.4e-12 | -0.34 | 0.18 | 0.48 | TRUE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | MYO9A | 0.13 | 0.08 | lasso | 3 | 0.08 | 1.7e-03 | 5.3 | -5.1 | 2.9e-07 | -0.10 | 0.55 | 0.15 | FALSE |
| 5 | GTEx | Nerve Tibial | MYO9A | 0.13 | 0.13 | lasso | 3 | 0.11 | 2.1e-08 | 5.5 | -6.4 | 1.7e-10 | -0.26 | 0.66 | 0.33 | FALSE |
| 6 | GTEx | Nerve Tibial | PARP6 | 0.09 | 0.07 | lasso | 11 | 0.06 | 7.2e-05 | 5.9 | 5.8 | 5.3e-09 | 0.53 | 0.16 | 0.72 | FALSE |
| 7 | GTEx | Stomach | MYO9A | 0.17 | 0.06 | lasso | 5 | 0.01 | 1.1e-01 | 5.6 | -5.4 | 7.2e-08 | -0.11 | 0.47 | 0.23 | FALSE |
| 8 | GTEx | Thyroid | PARP6 | 0.23 | 0.02 | enet | 21 | 0.07 | 9.0e-06 | 5.8 | 5.1 | 2.9e-07 | 0.27 | 0.23 | 0.76 | FALSE |
| 9 | The Cancer Genome Atlas | Esophageal Carcinoma | SENP8 | 0.30 | 0.04 | enet | 22 | 0.12 | 1.2e-04 | 5.4 | -5.2 | 1.8e-07 | -0.36 | 0.01 | 0.40 | FALSE |
| 10 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | NR2E3 | 0.07 | 0.02 | blup | 38 | 0.05 | 4.4e-03 | 5.3 | -5.2 | 1.8e-07 | -0.13 | 0.02 | 0.11 | FALSE |