TWAS hub - PML

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1410	0.0480	7.9e-04	0.021	NA	0.010	NA	0.017	9.1e-03	NA	5.8e-02	NA	1.9e-02
2	YFS	Blood	0.0482	0.0122	8.0e-11	0.052	0.037	0.049	0.047	0.051	1.5e-16	4.5e-12	1.1e-15	4.2e-15	3.8e-16

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Length of working week for main job	8.6	9.5	13.2	-2.4	-3.6
Coronary Artery Disease (CAD)	6.1	7.3	9.0	-3.0	-2.4
Hand grip strength (left)	6.0	15.7	27.0	5.2	2.1
Height	5.7	110.3	198.8	14.1	4.7
Peak expiratory flow (PEF)	5.7	13.3	22.7	4.8	2.0
Overall health rating	5.7	12.3	13.7	-3.3	-3.7
Hand grip strength (right)	5.4	14.7	25.9	5.1	1.9
Standing height	5.1	51.0	93.5	9.7	2.9
Commuting to job workplace: Cycle	4.8	5.9	7.1	2.7	2.1
Waist Hip Ratio (WHR)	4.7	21.1	32.9	-3.1	-5.7
Comparative height size at age 10	4.6	25.1	50.0	7.1	0.5
High blood pressure (mother)	4.5	6.2	11.4	-3.4	-1.1
Alzheimer’s Disease (in father)	4.4	4.7	9.0	0.7	3.0
Pulse rate	4.4	7.4	12.2	-3.5	-1.6
Sitting height	4.3	30.4	48.6	7.0	3.5
Leg fat percentage (left)	4.2	15.2	21.6	-4.7	-3.0
Heart disease (mother)	4.1	4.9	6.7	-1.8	-2.6
Neck or shoulder pain in last month	4.0	5.6	9.9	-3.1	-1.2
Medication: Seretide 50 evohaler	4.0	4.6	5.1	2.0	2.3
Age at last live birth	3.9	5.6	9.7	1.2	3.1
Age at first live birth	3.7	6.6	10.7	1.6	3.3
Leg pain on walking	3.7	4.6	7.4	-1.3	-2.7
Medication: Amlodipine	3.6	5.1	7.8	2.8	1.5
Health satisfaction	3.5	4.5	5.8	-2.4	-1.8
Medication: Atenolol	3.4	4.3	6.4	-1.4	-2.5
Forced vital capacity (FVC), Best measure	3.4	12.6	25.1	5.0	0.3
Pulse wave peak to peak time	3.4	4.0	7.9	2.8	0.4
Ulcerative Colitis	2.9	4.1	7.7	-0.8	-2.8
Leg fat percentage (right)	2.9	10.5	15.0	-3.9	-2.4
Medication: Allopurinol	2.9	3.9	6.5	1.1	2.5
Waist circumference	2.8	10.1	11.0	-3.0	-3.3
Illnesses of mother	2.8	3.5	5.1	2.3	1.4
Glaucoma (self-reported)	2.8	3.3	3.5	-1.9	-1.8
Body mass index (BMI)	2.7	11.5	17.1	-4.1	-2.4
Medication for pain relief, constipation, heartburn	2.7	4.7	6.7	2.6	1.6
Medication: Omeprazole	2.7	3.2	5.6	-2.4	-0.9
Pulse rate, automated reading	2.7	8.8	13.9	-3.7	-1.9
Illnesses of siblings: Diabetes	2.7	3.4	5.2	1.2	2.3
Forced expiratory volume in 1-second (FEV1), Best measure	2.6	8.4	16.7	4.1	0.1
Pain experienced in last month	2.6	4.4	4.7	2.2	2.0
Mouth/teeth dental problems: Mouth ulcers	2.5	4.0	5.1	1.7	2.3
Age at First Birth	2.4	3.5	6.0	2.4	1.0
BMI	2.4	13.7	22.6	-4.8	-2.2
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.9	5.3	-2.3	-1.6
Exposure to tobacco smoke at home	2.4	2.7	4.9	-2.2	-0.7
Guilty feelings	2.4	3.6	4.1	2.0	1.8
Hair/balding pattern: Pattern 2	2.3	2.9	3.0	-1.7	-1.7
Forced vital capacity (FVC)	2.3	8.9	17.6	4.2	0.5
Body fat percentage	2.3	9.1	9.9	-3.1	-2.9
Arm fat percentage (left)	2.3	9.0	12.1	-3.5	-2.4
Townsend deprivation index at recruitment	2.2	3.1	4.6	-2.1	-1.3
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.7	3.4	-1.4	-1.8
Trunk predicted mass	2.2	12.4	21.9	4.7	1.7
Maternal smoking around birth	2.1	3.0	5.8	-2.4	-0.5
Trunk fat-free mass	2.1	12.3	21.7	4.7	1.7
Forced expiratory volume in 1-second (FEV1)	2.1	7.1	14.1	3.8	0.3
Hair/balding pattern: Pattern 3	2.0	2.9	3.3	1.6	1.8
Pulse wave Arterial Stiffness index	2.0	2.4	4.7	-2.2	-0.3
High blood pressure (siblings)	2.0	2.9	4.5	-1.1	-2.1
Exposure to tobacco smoke outside home	2.0	2.7	3.3	-1.8	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	4.9	0.0	2.2
Osteoporosis (self-reported)	2.0	2.5	3.9	2.0	1.1
Type 2 Diabetes (T2D) (2012)	1.9	2.2	3.7	-1.9	-0.8
Chest pain or discomfort	1.9	2.8	5.6	-0.1	-2.4
Miserableness	1.9	3.4	4.8	-1.4	2.2
Pain type(s) experienced in last month: Hip pain	1.9	2.4	2.6	-1.5	-1.6
Fasting Glucose	1.8	2.2	4.2	-2.0	0.4
Arm fat percentage (right)	1.8	7.3	10.5	-3.2	-2.0
Illnesses of father: Heart disease	1.8	2.5	4.9	-0.1	-2.2
Supplements: Fish oil (including cod liver oil)	1.8	2.4	2.7	1.4	1.6
Hearing difficulty/problems: Yes	1.7	2.5	3.5	1.3	1.9
Trunk fat percentage	1.7	6.8	8.0	-2.4	-2.8
Falls in the last year	1.7	2.3	4.5	0.2	-2.1
Depressed Affect (Nagel 2018)	1.6	3.4	6.7	-0.2	2.6
Eye problems/disorders: Glaucoma	1.6	2.0	3.2	-0.8	-1.8
Average weekly beer plus cider intake	1.6	2.3	2.4	1.4	1.6
Leg fat mass (left)	1.6	6.1	6.4	-2.5	-2.4
Reaction Time	1.5	2.9	5.3	-2.3	-0.6
Vitamin and mineral supplements	1.5	2.0	2.6	-1.6	-1.2
Headache pain in last month	1.5	2.6	4.9	-2.2	-0.6
Mouth/teeth dental problems: Loose teeth	1.5	1.7	2.4	-1.6	-1.0
Knee pain experienced in last month	1.5	2.4	2.8	-1.4	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.7	3.4	-0.2	-1.8
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	2.9	-1.7	-0.8
Bipolar Disorder (2018)	1.4	2.2	4.0	-0.7	-2.0
Diabetes (father)	1.4	1.7	2.3	-1.5	-1.0
Multivitamins +/- minerals	1.4	1.8	2.0	1.3	1.4
Breastfed as a baby	1.4	1.8	3.2	-0.6	1.8
Gout (self-reported)	1.4	1.9	3.3	0.7	1.8
Qualifications: College or University degree	1.4	4.6	5.3	2.0	2.3
Eye problems/disorders: None of the above	1.4	1.6	3.2	0.2	1.8
Breast cancer (self-reported)	1.4	1.7	2.5	0.9	-1.6
Alcohol drinker status: Previous	1.4	1.6	3.2	-0.2	-1.8
Schizophrenia (2018)	1.3	2.6	4.6	2.1	0.8
Rheumatoid Arthritis	1.3	1.7	2.9	-0.8	-1.7
Neuroticism	1.3	3.0	4.4	1.3	2.1
Tense / ‘highly strung’	1.3	2.1	2.4	1.5	1.4
Chronic bronchitis/emphysema (mother)	1.3	1.5	2.6	-0.7	-1.6
Comparative body size at age 10	1.3	3.6	7.2	-2.7	-0.2
Had major operations	1.3	1.5	1.6	-1.2	-1.3
Whole body fat-free mass	1.3	7.6	14.0	3.7	1.1
Qualifications: nursing, teaching	1.3	2.0	2.5	1.2	1.6
Mineral and other dietary supplements	1.3	1.8	3.3	-1.8	-0.5
Age started oral contraceptive pill	1.3	1.7	2.0	1.4	1.2
Neuroticism (Nagel 2018)	1.2	2.8	4.0	1.3	2.0
Qualifications: CSEs or equivalent	1.2	1.6	2.5	-0.8	-1.6
Birth weight	1.2	2.7	5.4	2.3	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	1.7	1.2	1.3
Leg fat mass (right)	1.2	4.7	4.8	-2.2	-2.1
Average weekly red wine intake	1.2	1.7	2.7	-0.9	-1.6
Mood swings	1.2	2.2	4.2	0.3	2.1
Whole body water mass	1.2	7.0	12.9	3.6	1.1
Sensitivity / hurt feelings	1.1	1.9	3.3	0.7	1.8
Pain all over the body in last month	1.1	1.1	2.2	0.3	-1.5
Neuroticism score	1.1	2.3	3.2	1.2	1.8
Worry too long after embarrassment	1.1	1.8	3.5	1.9	-0.2
Medication: Ibuprofen	1.1	1.3	1.3	-1.1	-1.1
Loneliness, isolation	1.1	1.5	2.7	0.6	1.6
Illnesses of father: None of the above (group 1)	1.1	1.4	1.9	0.9	1.4
Hearing aid user	1.1	1.2	2.0	0.7	1.4
Mother’s age at death	1.1	1.3	2.3	1.5	0.6
Ulcerative Colitis (UC)	1.0	1.8	3.5	-0.3	-1.9
Respiratory disease	1.0	2.3	2.8	1.7	1.4
Alcohol intake versus 10 years previously	1.0	1.5	2.6	0.6	1.6
Loud music exposure frequency	1.0	1.1	2.2	1.5	0.3
Qualifications: O levels/GCSEs or equivalent	1.0	1.7	2.6	-1.6	0.8
Medication: Paracetamol	1.0	1.7	2.2	-1.5	-1.1
Number of full brothers	1.0	1.2	2.5	-1.6	-0.0
Emphysema/chronic bronchitis	1.0	1.1	1.1	1.0	-1.1
Mean time to correctly identify matches	1.0	1.9	3.6	-1.9	-0.4
Back pain experienced in last month	1.0	1.5	1.6	-1.3	-1.2
Arm fat mass (left)	1.0	4.0	4.3	-2.1	-1.9
Illnesses of father: High blood pressure	1.0	1.3	1.4	-1.1	-1.2
Supplements: Calcium	1.0	1.1	1.1	1.1	-1.0
Worry (Nagel 2018)	0.9	1.8	2.4	1.6	1.1
Major Depression (MDD)	0.9	1.1	1.4	-0.9	-1.2
Breast Cancer	0.9	2.2	3.9	2.0	0.8
Supplements: Zinc	0.9	1.0	1.8	1.3	-0.4
Illnesses of siblings	0.9	1.2	2.1	0.6	1.4
Prospective memory result	0.9	1.1	2.0	0.3	1.4
Arm fat mass (right)	0.9	3.7	4.1	-2.0	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	2.0	0.2	-1.4
Handedness (chirality/laterality): Left-handed	0.9	1.0	1.2	-1.1	-0.9
Ever had bowel cancer screening	0.9	1.0	1.7	0.6	1.3
Cholesterol lowering medication	0.9	1.3	1.8	-1.3	-0.9
HDL Cholesterol	0.8	1.3	1.8	1.3	1.0
Average weekly spirits intake	0.8	1.0	1.2	-0.9	-1.1
Fed-up feelings	0.8	1.5	2.2	-0.9	1.5
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	1.7	-0.7	-1.3
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.0	0.2	-1.4
Ever taken oral contraceptive pill	0.8	0.9	1.5	-1.2	-0.5
High cholesterol (Self-reported)	0.8	1.4	2.7	-1.6	-0.2
Diastolic blood pressure, automated reading	0.8	2.4	4.2	-2.0	-0.8
LDL Cholesterol	0.7	1.2	2.4	0.1	1.5
Blood White Count	0.7	5.0	5.9	-2.4	-2.0
Allergy or Eczema	0.7	1.8	2.9	0.9	1.7
Number of treatments/medications taken	0.7	1.3	2.3	-0.5	-1.5
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.4	1.2	0.2
Angina	0.7	0.9	1.7	-0.2	-1.3
Leg fat-free mass (left)	0.7	3.6	7.0	2.6	0.4
Trunk fat mass	0.7	2.9	4.7	-1.1	-2.2
Impedance of arm (right)	0.7	3.4	6.7	2.6	0.1
Medication: Lansoprazole	0.7	0.8	1.1	-1.0	-0.8
Impedance of arm (left)	0.7	3.3	6.6	2.6	0.0
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.3	0.6	1.5
Arm fat-free mass (right)	0.7	3.7	7.4	2.7	0.4
Whole body fat mass	0.7	3.0	4.2	-1.3	-2.1
Arm predicted mass (right)	0.7	3.5	7.0	2.6	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.6	1.6	-0.3
Medication: Lisinopril	0.7	0.9	1.4	1.2	0.6
Alcohol drinker status: Never	0.7	0.9	1.8	-0.1	-1.3
Ever smoked	0.7	1.2	1.9	1.4	0.7
Basal metabolic rate	0.7	4.0	7.7	2.8	0.5
Risk taking	0.7	1.1	2.1	1.5	-0.1
Ever depressed for a whole week	0.7	0.9	1.8	-1.4	-0.1
Basal cell carcinoma (self-reported)	0.7	0.8	1.5	1.2	-0.5
Medication: Co-codamol	0.6	0.7	1.1	-1.1	-0.5
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.0	-0.6	-1.0
Medication: Levothyroxine sodium	0.6	1.0	1.7	0.4	1.3
Leg predicted mass (left)	0.6	3.4	6.7	2.6	0.3
Diabetes (self-reported)	0.6	0.9	1.8	0.3	-1.3
Depression (self-reported)	0.6	0.7	1.1	-1.0	-0.6
Birth weight of first child	0.6	1.0	2.0	0.3	1.4
Shortness of breath walking on level ground	0.6	0.7	1.3	-1.2	-0.1
Angina (self-reported)	0.6	0.8	1.6	0.0	-1.3
Family relationship satisfaction	0.6	0.7	1.5	-1.2	-0.1
Supplements: Vitamin C	0.6	0.7	1.0	-0.6	-1.0
Financial situation satisfaction	0.6	0.8	0.9	-1.0	-0.8
Medication: Paracetamol	0.6	0.9	1.6	-1.3	-0.4
Arm fat-free mass (left)	0.6	3.1	5.9	2.4	0.5
Arm predicted mass (left)	0.6	3.1	5.9	2.4	0.6
Schizophrenia vs Biploar Disorder	0.5	0.6	1.2	0.1	1.1
Lupus	0.5	0.7	1.2	1.1	-0.5
Blood Red Count	0.5	4.4	6.0	-1.7	-2.5
Lung FVC	0.5	2.6	3.8	1.9	1.2
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.0	1.0	0.4
Severe depression (siblings)	0.5	0.6	0.8	-0.6	-0.9
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	0.8	-0.7	-0.9
Chronic bronchitis/emphysema (father)	0.5	0.6	0.9	-0.5	-0.9
Number of incorrect matches in round	0.5	0.9	1.4	1.2	0.7
Past tobacco smoking	0.5	0.9	1.8	-1.3	0.2
Alcohol usually taken with meals	0.5	0.8	1.1	-0.6	1.1
Had menopause	0.5	0.7	1.3	1.1	-0.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	0.9	-0.6	0.9
Time employed in main current job	0.5	0.6	1.1	1.1	0.2
Father’s age at death	0.5	0.7	1.0	1.0	0.5
Noisy workplace	0.5	0.6	1.2	-0.0	1.1
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.1	-0.2	1.4
Mouth/teeth dental problems: Dentures	0.5	0.8	1.3	1.1	-0.6
Medication: Cholesterol lowering	0.5	0.8	1.3	-1.1	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.0	-0.3	-1.0
Smoking status: Previous	0.5	0.8	1.4	1.2	0.5
Leg fat-free mass (right)	0.5	2.6	5.2	2.3	0.1
Long-standing illness, disability or infirmity	0.5	0.7	1.0	-0.7	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.1	-0.0	-1.0
Friendships satisfaction	0.5	0.6	0.9	0.5	-0.9
Medication: Gliclazide	0.5	0.6	1.1	-0.2	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.1	1.4	0.3
Leg predicted mass (right)	0.5	2.8	5.6	2.4	0.2
Medication: Atorvastatin	0.5	0.6	1.1	-1.1	0.2
Number of operations (self-reported)	0.5	0.8	0.9	-1.0	-0.8
Unable to work because of sickness or disability	0.5	0.6	0.8	-0.9	-0.7
Bipolar Disorder or Schizophrenia	0.4	1.0	1.6	1.2	-0.6
Irritable Bowel Disease (IBD)	0.4	1.0	2.0	-0.2	-1.4
Mean Putamen Volume	0.4	0.5	0.6	0.6	0.8
Primary Biliary Cirrhosis	0.4	0.5	0.6	0.7	0.7
Blood Eosinophil Count	0.4	3.1	5.6	-0.8	-2.4
Type 2 Diabetes (T2D) (2018)	0.4	0.8	0.9	-1.0	-0.8
Relative age voice broke	0.4	0.6	0.9	0.5	0.9
Age when periods started (menarche)	0.4	1.0	1.9	0.4	1.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.8	0.9	-0.3
Lung cancer (father)	0.4	0.4	0.8	0.2	0.9
Medication: Blood pressure	0.4	0.7	1.0	0.6	-1.0
Eye problems/disorders: Cataract	0.4	0.5	1.0	0.0	-1.0
Osteoarthritis (self-reported)	0.4	0.6	1.1	-0.2	-1.0
Commuting to job workplace: Public transport	0.4	0.5	0.8	-0.3	-0.9
Fractured/broken bones in last 5 years	0.4	0.6	1.2	0.0	-1.1
Myopia	0.4	0.6	0.9	0.9	-0.6
Alzheimer’s Disease (including proxy)	0.3	0.5	0.6	0.6	0.7
Bipolar Disorder (2011)	0.3	0.3	0.6	0.1	0.8
HbA1C	0.3	0.4	0.8	-0.9	0.0
Triglycerides	0.3	0.5	0.8	-0.9	0.5
Smoking Status	0.3	0.7	1.2	1.1	0.4
Ever had hysterectomy (womb removed)	0.3	0.3	0.4	0.5	0.6
Average weekly fortified wine intake	0.3	0.4	0.6	-0.5	0.8
Migraine (self-reported)	0.3	0.4	0.7	0.3	-0.8
Suffer from ‘nerves’	0.3	0.4	0.8	0.9	-0.1
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	-0.7	-0.2
Diabetes diagnosed by doctor	0.3	0.6	1.0	-0.3	-1.0
Commuting to job workplace: Walk	0.3	0.3	0.6	0.8	0.1
Number of self-reported non-cancer illnesses	0.3	0.5	0.9	0.9	-0.4
Average weekly champagne plus white wine intake	0.3	0.4	0.6	0.4	0.8
Heart disease (siblings)	0.3	0.3	0.6	-0.8	-0.3
Impedance of whole body	0.3	1.8	3.2	1.8	-0.6
Ovarian Cancer	0.2	0.2	0.3	0.4	-0.6
Neuroticism (2016)	0.2	0.4	0.7	0.8	0.2
Blood Platelet Count	0.2	1.7	2.7	-1.6	-0.9
Heel T-Score	0.2	1.4	1.9	0.9	-1.4
Hypothyroidism (self reported)	0.2	0.5	1.0	-0.2	1.0
Tanning	0.2	2.4	2.6	1.6	1.5
Relative age of first facial hair	0.2	0.3	0.5	0.7	-0.4
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.5	0.1	-0.7
Impedance of leg (right)	0.2	1.0	2.0	1.4	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.4	-0.4	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.7	0.1	-0.8
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.5	0.7	0.0
Medication: Simvastatin	0.2	0.3	0.4	-0.6	-0.3
Fluid intelligence score	0.2	0.4	0.7	0.9	0.2
Asthma	0.2	0.3	0.4	0.6	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.5	-0.7	-0.4
Number of children fathered	0.2	0.3	0.5	0.2	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.5	-0.7	0.3
Medication: Aspirin	0.2	0.3	0.5	0.0	-0.7
Medication for cholesterol	0.2	0.2	0.5	0.7	-0.0
Asthma (self-reported)	0.2	0.5	0.6	0.7	0.6
Smoking status: Current	0.2	0.3	0.3	0.6	-0.4
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.3	-0.6	0.5
Medication: Bendroflumethiazide	0.2	0.3	0.4	0.4	0.6
Depression (Nagel 2018)	0.1	0.1	0.3	0.1	0.5
Prostate Cancer	0.1	0.2	0.4	-0.6	-0.1
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.2	0.4
Schizophrenia (2014)	0.1	0.2	0.4	0.7	-0.2
Cardiovascular Disease	0.1	0.3	0.4	-0.7	-0.3
Chronotype (morning person)	0.1	0.3	0.5	0.1	-0.7
Hair Pigment	0.1	1.7	2.6	-1.6	-0.9
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.1	-0.4	0.3
Medication for hormone replacement therapy	0.1	0.1	0.3	0.1	0.5
Medication: Metformin	0.1	0.1	0.2	-0.5	0.2
Current tobacco smoking	0.1	0.2	0.4	0.7	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	0.0	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.3	0.3	-0.6
High blood pressure	0.1	0.2	0.5	0.7	0.1
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.2	-0.4
Supplements: Glucosamine	0.1	0.1	0.2	0.5	-0.1
Impedance of leg (left)	0.1	0.6	1.0	0.5	-1.0
Financial difficulties in last 2 years	0.1	0.1	0.2	-0.4	0.3
Heart attack	0.1	0.2	0.3	-0.1	-0.6
Medication: Ramipril	0.1	0.1	0.1	-0.3	-0.4
Weight	0.1	0.4	0.7	0.4	-0.8
Hip circumference	0.1	0.3	0.5	-0.7	-0.2
Worrier / anxious feelings	0.1	0.1	0.2	0.4	0.2
Number of live births	0.1	0.1	0.2	-0.1	-0.4
Happiness	0.1	0.1	0.3	-0.5	0.0
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.3	0.5	-0.2
Blood clot in the leg (DVT)	0.1	0.2	0.4	-0.0	-0.6
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	0.4	-0.4
Number of full sisters	0.1	0.2	0.3	-0.6	-0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.3	-0.5	-0.2
Hypertension (Self-reported)	0.1	0.3	0.5	0.7	0.1
Medication: Aspirin	0.1	0.1	0.3	0.2	-0.5
Wears glasses or contact lenses	0.1	0.2	0.3	-0.1	0.6
Irritability	0.1	0.2	0.3	-0.1	0.5
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.3	-0.5	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	-0.1	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.1	-0.5
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.2	-0.5	-0.1
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	-0.1	-0.2
Crohns Disease (2017)	0.0	0.0	0.0	-0.0	-0.0
Verbal and Numeric Reasoning (VNR)	0.0	0.0	0.0	-0.0	0.1
Crohns Disease (2012)	0.0	0.1	0.2	0.4	0.0
Systolic Blood Pressure	0.0	0.2	0.3	-0.4	-0.5
Lung FEV1/FVC ratio	0.0	0.0	0.1	0.3	-0.0
Systolic blood pressure, automated reading	0.0	0.0	0.0	-0.0	0.2
Diabetes (mother)	0.0	0.0	0.0	-0.1	-0.1
Pack years adult smoking proportion	0.0	0.0	0.0	-0.1	0.1
Taking other prescription medications	0.0	0.0	0.1	-0.1	-0.3
Serious illness, injury or assault to yourself	0.0	0.0	0.0	-0.2	0.0
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	-0.4	0.0
Nervous feelings	0.0	0.0	0.0	-0.0	0.2
Hearing difficulty/problems with background noise	0.0	0.0	0.0	0.0	0.1
Had other major operations	0.0	0.1	0.1	0.3	0.2
Qualifications: None of the above	0.0	0.0	0.0	0.1	-0.2
Mouth/teeth dental problems	0.0	0.0	0.0	-0.2	0.0
Allergy	0.0	0.0	0.1	-0.2	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.1	0.3	0.2
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	-0.2	0.4
Pulse wave reflection index	0.0	0.0	0.0	-0.0	0.0
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.1	-0.2	0.4
Alcohol intake frequency.	0.0	0.0	0.1	-0.3	-0.1
Medication: Blood pressure	0.0	0.1	0.1	0.4	0.0
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.1	0.2	0.1
Pack years of smoking	0.0	0.0	0.1	0.1	0.2

Hub : Genes

PML

Models

Trait associations