Best TWAS P=7.88e-10 · Best GWAS P=6.65e-15 conditioned to 2.15e-10
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | AP1G1 | 0.10 | 0.09 | lasso | 2 | 0.07 | 1.3e-04 | -5.2 | -5.2 | 1.6e-07 | 0.30 | 0.07 | 0.87 | FALSE |
| 2 | GTEx | Skin Sun Exposed Lower leg | AP1G1 | 0.06 | 0.00 | enet | 15 | 0.01 | 5.7e-02 | -5.2 | -5.8 | 7.2e-09 | 0.38 | 0.07 | 0.85 | FALSE |
| 3 | GTEx | Testis | PHLPP2 | 0.29 | 0.38 | enet | 20 | 0.37 | 3.0e-17 | -5.8 | 5.7 | 1.5e-08 | -0.30 | 0.02 | 0.98 | FALSE |
| 4 | YFS | Blood | ATXN1L | 0.02 | 0.02 | blup | 413 | 0.02 | 6.5e-07 | 4.8 | 5.6 | 1.9e-08 | -0.33 | 0.81 | 0.18 | FALSE |
| 5 | YFS | Blood | PHLPP2 | 0.04 | 0.03 | bslmm | 459 | 0.05 | 5.5e-16 | -5.8 | 5.2 | 1.6e-07 | -0.25 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Esophageal Carcinoma | PHLPP2 | 0.18 | 0.03 | blup | 67 | 0.07 | 2.9e-03 | -5.8 | -6.2 | 7.9e-10 | 0.27 | 0.02 | 0.74 | TRUE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AP1G1 | 0.03 | 0.03 | lasso | 4 | 0.02 | 2.1e-03 | -4.4 | -5.6 | 2.2e-08 | 0.27 | 0.02 | 0.86 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | MARVELD3 | 0.08 | 0.01 | blup | 44 | 0.06 | 7.1e-07 | -5.7 | 6.0 | 2.7e-09 | -0.26 | 0.02 | 0.96 | FALSE |