Best TWAS P=8.34e-14 · Best GWAS P=1.12e-11 conditioned to 0.522
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RANBP10 | 0.05 | 0.01 | lasso | 6 | 0.01 | 3.5e-02 | -5.7 | 5.3 | 1.4e-07 | -0.79 | 0.15 | 0.76 | FALSE |
| 2 | GTEx | Artery Tibial | RANBP10 | 0.08 | 0.04 | lasso | 3 | 0.05 | 6.4e-05 | -6.7 | 6.7 | 3.0e-11 | -0.92 | 0.03 | 0.96 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | RANBP10 | 0.10 | 0.01 | enet | 29 | 0.03 | 2.8e-03 | -6.0 | 5.4 | 5.4e-08 | -0.62 | 0.05 | 0.36 | FALSE |
| 4 | GTEx | Esophagus Muscularis | RANBP10 | 0.13 | 0.05 | lasso | 4 | 0.02 | 2.3e-02 | -6.7 | 6.5 | 8.1e-11 | -0.88 | 0.03 | 0.96 | FALSE |
| 5 | GTEx | Muscle Skeletal | C16orf86 | 0.05 | 0.04 | lasso | 2 | 0.03 | 4.0e-04 | -5.9 | 6.1 | 9.3e-10 | -0.82 | 0.06 | 0.75 | FALSE |
| 6 | GTEx | Nerve Tibial | RANBP10 | 0.15 | 0.14 | lasso | 7 | 0.13 | 1.8e-09 | -5.9 | 6.5 | 6.0e-11 | -0.88 | 0.11 | 0.89 | FALSE |
| 7 | GTEx | Pituitary | ZDHHC1 | 0.23 | 0.13 | lasso | 4 | 0.08 | 4.0e-03 | -5.9 | -5.2 | 2.2e-07 | 0.74 | 0.04 | 0.48 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | ZDHHC1 | 0.10 | 0.00 | lasso | 7 | 0.00 | 5.1e-01 | -6.7 | 6.6 | 3.4e-11 | -0.87 | 0.02 | 0.77 | FALSE |
| 9 | GTEx | Spleen | ATP6V0D1 | 0.36 | 0.03 | enet | 9 | 0.07 | 6.0e-03 | -2.4 | 5.3 | 1.0e-07 | -0.82 | 0.03 | 0.34 | FALSE |
| 10 | GTEx | Testis | DUS2 | 0.15 | 0.01 | enet | 9 | 0.03 | 1.1e-02 | 3.8 | 6.5 | 8.3e-11 | -0.61 | 0.16 | 0.49 | FALSE |
| 11 | GTEx | Testis | RP11-67A1.2 | 0.20 | 0.02 | lasso | 6 | 0.09 | 8.3e-05 | 3.7 | 6.3 | 3.3e-10 | -0.56 | 0.08 | 0.89 | FALSE |
| 12 | GTEx | Thyroid | RANBP10 | 0.08 | 0.03 | lasso | 4 | 0.03 | 2.2e-03 | -5.9 | 6.4 | 1.7e-10 | -0.86 | 0.06 | 0.80 | FALSE |
| 13 | GTEx | Thyroid | ZDHHC1 | 0.07 | 0.03 | lasso | 6 | 0.02 | 1.6e-02 | -6.7 | -6.6 | 3.2e-11 | 0.99 | 0.01 | 0.96 | FALSE |
| 14 | GTEx | Thyroid | HSD11B2 | 0.15 | 0.07 | enet | 23 | 0.09 | 1.9e-07 | -5.9 | -6.1 | 8.7e-10 | 0.86 | 0.35 | 0.65 | FALSE |
| 15 | GTEx | Whole Blood | DUS2 | 0.12 | 0.04 | enet | 10 | 0.05 | 4.0e-05 | -5.9 | -5.7 | 1.3e-08 | 0.74 | 0.11 | 0.89 | FALSE |
| 16 | METSIM | Adipose | CTCF | 0.03 | 0.02 | bslmm | 222 | 0.01 | 3.4e-03 | -6.8 | -7.3 | 3.1e-13 | 0.90 | 0.02 | 0.90 | FALSE |
| 17 | METSIM | Adipose | LRRC36 | 0.10 | 0.07 | lasso | 24 | 0.10 | 1.6e-14 | -6.8 | -6.6 | 3.8e-11 | 0.95 | 0.02 | 0.98 | FALSE |
| 18 | METSIM | Adipose | RLTPR | 0.04 | 0.00 | bslmm | 211 | 0.00 | 1.1e-01 | -6.8 | -7.0 | 1.9e-12 | 0.83 | 0.03 | 0.80 | FALSE |
| 19 | YFS | Blood | ATP6V0D1 | 0.14 | 0.18 | lasso | 15 | 0.20 | 1.8e-63 | -6.4 | 5.6 | 2.3e-08 | -0.92 | 0.04 | 0.96 | FALSE |
| 20 | YFS | Blood | ZDHHC1 | 0.05 | 0.05 | enet | 26 | 0.05 | 1.8e-16 | -6.4 | -5.9 | 4.4e-09 | 0.85 | 0.05 | 0.95 | FALSE |
| 21 | The Cancer Genome Atlas | Breast Invasive Carcinoma | KCTD19 | 0.02 | 0.02 | blup | 29 | 0.03 | 3.5e-06 | -6.2 | -5.8 | 8.0e-09 | 0.53 | 0.11 | 0.87 | FALSE |
| 22 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LRRC36 | 0.04 | 0.04 | enet | 8 | 0.05 | 5.8e-10 | -6.2 | -6.0 | 2.1e-09 | 0.73 | 0.18 | 0.82 | FALSE |
| 23 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZDHHC1 | 0.02 | 0.01 | lasso | 1 | 0.01 | 2.4e-03 | -6.7 | 6.7 | 2.6e-11 | -0.99 | 0.01 | 0.88 | FALSE |
| 24 | The Cancer Genome Atlas | Colon Adenocarcinoma | CENPT | 0.05 | 0.05 | enet | 8 | 0.04 | 3.0e-03 | -5.9 | -6.2 | 4.7e-10 | 0.71 | 0.01 | 0.90 | FALSE |
| 25 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GFOD2 | 0.03 | 0.03 | lasso | 1 | 0.03 | 3.6e-04 | -5.8 | 5.8 | 5.9e-09 | -0.76 | 0.01 | 0.98 | FALSE |
| 26 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TPPP3 | 0.03 | 0.02 | blup | 31 | 0.04 | 2.1e-05 | -6.8 | 6.6 | 5.1e-11 | -0.92 | 0.02 | 0.98 | FALSE |
| 27 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LRRC36 | 0.07 | 0.03 | blup | 39 | 0.03 | 2.5e-04 | -6.4 | -7.0 | 3.8e-12 | 0.86 | 0.06 | 0.94 | FALSE |
| 28 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RANBP10 | 0.04 | 0.03 | blup | 31 | 0.04 | 6.5e-05 | -5.8 | 5.4 | 6.2e-08 | -0.73 | 0.02 | 0.95 | FALSE |
| 29 | The Cancer Genome Atlas | Lung Adenocarcinoma | C16orf86 | 0.04 | 0.04 | lasso | 2 | 0.03 | 3.8e-04 | -6.0 | 6.0 | 2.1e-09 | -0.80 | 0.00 | 0.98 | FALSE |
| 30 | The Cancer Genome Atlas | Lung Adenocarcinoma | RLTPR | 0.03 | 0.02 | lasso | 3 | 0.02 | 1.8e-03 | -5.4 | 5.7 | 1.0e-08 | -0.79 | 0.00 | 0.88 | FALSE |
| 31 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | AGRP | 0.11 | 0.01 | enet | 6 | 0.07 | 2.5e-05 | 1.7 | -6.4 | 2.1e-10 | 0.64 | 0.01 | 0.56 | FALSE |
| 32 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C16orf86 | 0.05 | 0.05 | lasso | 1 | 0.04 | 2.9e-05 | -6.0 | 6.0 | 2.5e-09 | -0.80 | 0.00 | 1.00 | FALSE |
| 33 | The Cancer Genome Atlas | Rectum Adenocarcinoma | LRRC36 | 0.13 | 0.12 | lasso | 14 | 0.11 | 1.4e-03 | -6.8 | -6.8 | 1.1e-11 | 1.00 | 0.01 | 0.66 | FALSE |
| 34 | The Cancer Genome Atlas | Stomach Adenocarcinoma | AGRP | 0.04 | 0.02 | blup | 23 | 0.03 | 3.0e-03 | -6.7 | -7.5 | 8.3e-14 | 0.87 | 0.01 | 0.74 | TRUE |
| 35 | The Cancer Genome Atlas | Thyroid Carcinoma | C16orf48 | 0.04 | 0.02 | blup | 17 | 0.04 | 8.5e-05 | -6.0 | 5.6 | 2.2e-08 | -0.69 | 0.00 | 0.84 | FALSE |
| 36 | The Cancer Genome Atlas | Thyroid Carcinoma | LRRC36 | 0.04 | 0.04 | lasso | 3 | 0.04 | 1.5e-04 | -6.7 | -6.7 | 1.8e-11 | 0.99 | 0.01 | 0.99 | FALSE |
| 37 | The Cancer Genome Atlas | Thyroid Carcinoma | ZDHHC1 | 0.07 | 0.06 | enet | 7 | 0.07 | 2.9e-07 | -6.6 | -6.7 | 1.9e-11 | 0.95 | 0.02 | 0.98 | FALSE |