Best TWAS P=8.23e-14 · Best GWAS P=1.72e-11 conditioned to 0.914
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SERPINF1 | 0.34 | 0.30 | enet | 24 | 0.34 | 2.2e-43 | 6.7 | -6.4 | 1.4e-10 | -0.96 | 0.00 | 1.00 | FALSE |
2 | GTEx | Adipose Subcutaneous | SERPINF1 | 0.19 | 0.05 | lasso | 6 | 0.02 | 6.3e-03 | 6.7 | -6.4 | 1.4e-10 | -0.89 | 0.01 | 0.97 | FALSE |
3 | GTEx | Adipose Subcutaneous | SMYD4 | 0.20 | 0.14 | lasso | 2 | 0.16 | 2.6e-13 | 6.7 | -6.7 | 2.7e-11 | -0.97 | 0.01 | 0.99 | FALSE |
4 | GTEx | Artery Tibial | SMYD4 | 0.20 | 0.18 | enet | 10 | 0.18 | 8.2e-14 | 6.5 | -6.6 | 4.8e-11 | -0.98 | 0.01 | 0.99 | FALSE |
5 | GTEx | Brain Cortex | SMYD4 | 0.34 | 0.17 | lasso | 4 | 0.23 | 5.3e-07 | 6.3 | -7.5 | 8.2e-14 | -0.86 | 0.01 | 0.95 | TRUE |
6 | GTEx | Cells Transformed fibroblasts | SERPINF1 | 0.20 | 0.11 | lasso | 3 | 0.16 | 5.6e-12 | 6.7 | -6.8 | 1.3e-11 | -0.85 | 0.00 | 1.00 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | SMYD4 | 0.23 | 0.18 | lasso | 4 | 0.23 | 5.9e-17 | 6.5 | -5.3 | 1.4e-07 | -0.87 | 0.01 | 0.99 | FALSE |
8 | GTEx | Colon Sigmoid | SMYD4 | 0.33 | 0.24 | lasso | 7 | 0.24 | 5.0e-09 | 6.5 | -6.8 | 8.5e-12 | -0.99 | 0.01 | 0.99 | FALSE |
9 | GTEx | Esophagus Muscularis | SMYD4 | 0.24 | 0.16 | lasso | 3 | 0.18 | 3.1e-11 | 6.5 | -6.8 | 1.4e-11 | -0.97 | 0.01 | 0.99 | FALSE |
10 | GTEx | Lung | SMYD4 | 0.10 | 0.09 | lasso | 3 | 0.09 | 1.4e-07 | 6.5 | -6.5 | 7.2e-11 | -0.97 | 0.01 | 0.99 | FALSE |
11 | GTEx | Nerve Tibial | SMYD4 | 0.23 | 0.14 | lasso | 4 | 0.17 | 3.2e-12 | 6.3 | -6.6 | 5.1e-11 | -0.96 | 0.02 | 0.98 | FALSE |
12 | GTEx | Skin Not Sun Exposed Suprapubic | SMYD4 | 0.28 | 0.06 | enet | 36 | 0.12 | 5.8e-07 | 6.7 | -5.4 | 7.2e-08 | -0.64 | 0.01 | 0.99 | FALSE |
13 | GTEx | Testis | SMYD4 | 0.24 | 0.09 | enet | 14 | 0.10 | 2.9e-05 | 6.4 | -5.8 | 9.1e-09 | -0.78 | 0.02 | 0.96 | FALSE |
14 | GTEx | Thyroid | SMYD4 | 0.32 | 0.13 | enet | 11 | 0.23 | 1.5e-17 | 6.7 | -7.1 | 1.3e-12 | -0.91 | 0.00 | 1.00 | FALSE |
15 | YFS | Blood | SMYD4 | 0.17 | 0.15 | bslmm | 436 | 0.18 | 1.2e-55 | 6.5 | -6.1 | 1.3e-09 | -0.89 | 0.02 | 0.98 | FALSE |
16 | YFS | Blood | WDR81 | 0.17 | 0.16 | enet | 22 | 0.18 | 1.3e-57 | 6.7 | 5.2 | 1.6e-07 | 0.85 | 0.00 | 1.00 | FALSE |
17 | The Cancer Genome Atlas | Glioblastoma Multiforme | SMYD4 | 0.20 | 0.10 | lasso | 6 | 0.20 | 1.3e-06 | 6.3 | -6.4 | 1.5e-10 | -0.84 | 0.01 | 0.94 | FALSE |
18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SMYD4 | 0.12 | 0.10 | lasso | 7 | 0.14 | 1.2e-15 | 6.3 | -5.6 | 2.7e-08 | -0.86 | 0.02 | 0.98 | FALSE |
19 | The Cancer Genome Atlas | Lung Adenocarcinoma | SERPINF2 | 0.13 | 0.09 | lasso | 4 | 0.10 | 1.9e-11 | -4.6 | 5.2 | 1.5e-07 | 0.06 | 1.00 | 0.00 | TRUE |
20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SMYD4 | 0.08 | 0.09 | lasso | 9 | 0.08 | 6.3e-09 | 6.4 | -6.2 | 7.3e-10 | -0.97 | 0.01 | 0.99 | FALSE |
21 | The Cancer Genome Atlas | Thyroid Carcinoma | SMYD4 | 0.08 | 0.09 | lasso | 3 | 0.07 | 3.5e-07 | 6.3 | -6.4 | 1.9e-10 | -0.92 | 0.03 | 0.97 | FALSE |