Best TWAS P=6.85e-12 · Best GWAS P=1.92e-13 conditioned to 0.0138
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CHRNB1 | 0.09 | 0.06 | lasso | 2 | 0.08 | 9.8e-10 | 5.7 | 5.4 | 5.8e-08 | 0.02 | 0.00 | 1.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | EIF5A | 0.20 | 0.12 | bslmm | 446 | 0.10 | 1.2e-12 | -5.1 | -5.6 | 1.8e-08 | -0.06 | 0.11 | 0.88 | TRUE |
| 3 | CommonMind | Brain Pre-frontal Cortex | PFAS | 0.10 | 0.09 | lasso | 4 | 0.10 | 8.9e-13 | -4.0 | -5.3 | 1.1e-07 | 0.46 | 0.99 | 0.01 | FALSE |
| 4 | GTEx | Adipose Visceral Omentum | CHRNB1 | 0.29 | 0.14 | lasso | 5 | 0.14 | 1.0e-07 | 5.7 | 5.8 | 4.8e-09 | 0.02 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Male) | CHRNB1 | 0.28 | -0.01 | lasso | 6 | 0.02 | 9.6e-02 | 5.7 | 5.5 | 3.3e-08 | 0.01 | 0.01 | 0.83 | FALSE |
| 6 | GTEx | Esophagus Mucosa | CHRNB1 | 0.19 | 0.11 | lasso | 2 | 0.13 | 7.3e-09 | 5.7 | 5.7 | 1.1e-08 | 0.01 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Muscle Skeletal | EIF5A | 0.14 | 0.06 | enet | 35 | 0.05 | 4.2e-06 | -4.6 | -5.6 | 2.1e-08 | -0.01 | 0.32 | 0.67 | FALSE |
| 8 | GTEx | Pancreas | TRAPPC1 | 0.17 | 0.00 | lasso | 6 | 0.01 | 1.5e-01 | 4.3 | 5.8 | 5.9e-09 | -0.15 | 0.11 | 0.06 | FALSE |
| 9 | GTEx | Skin Not Sun Exposed Suprapubic | CHRNB1 | 0.17 | 0.15 | lasso | 3 | 0.16 | 7.4e-09 | 5.7 | 5.7 | 1.5e-08 | 0.01 | 0.01 | 0.99 | FALSE |
| 10 | GTEx | Stomach | CHRNB1 | 0.28 | 0.19 | lasso | 4 | 0.23 | 2.0e-11 | 5.7 | 5.3 | 1.2e-07 | 0.00 | 0.00 | 1.00 | FALSE |
| 11 | METSIM | Adipose | PFAS | 0.10 | 0.00 | blup | 450 | 0.03 | 1.7e-05 | -5.7 | -5.6 | 1.8e-08 | 0.36 | 0.02 | 0.82 | TRUE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | PFAS | 0.08 | 0.02 | enet | 10 | 0.03 | 4.4e-05 | -5.7 | -5.3 | 1.4e-07 | 0.40 | 0.91 | 0.03 | FALSE |
| 13 | YFS | Blood | CHRNB1 | 0.04 | 0.02 | lasso | 5 | 0.04 | 8.5e-12 | 5.8 | 5.4 | 6.8e-08 | 0.03 | 0.00 | 1.00 | FALSE |
| 14 | YFS | Blood | EIF5A | 0.61 | 0.64 | enet | 29 | 0.65 | 1.4e-287 | -5.1 | -5.2 | 2.3e-07 | -0.02 | 0.11 | 0.89 | FALSE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | AURKB | 0.02 | 0.01 | blup | 49 | 0.01 | 2.9e-03 | 1.8 | -5.4 | 7.0e-08 | 0.39 | 0.00 | 0.63 | FALSE |
| 16 | The Cancer Genome Atlas | Glioblastoma Multiforme | AMAC1L3 | 0.14 | 0.12 | lasso | 3 | 0.12 | 1.8e-04 | 5.4 | -5.5 | 4.0e-08 | -0.06 | 0.01 | 0.86 | FALSE |
| 17 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ALOXE3 | 0.04 | 0.00 | blup | 77 | 0.01 | 3.4e-02 | -3.9 | -6.9 | 6.9e-12 | 0.62 | 0.01 | 0.60 | TRUE |
| 18 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C17orf68 | 0.05 | 0.00 | blup | 59 | 0.03 | 3.3e-04 | -3.7 | -5.5 | 3.6e-08 | 0.47 | 0.01 | 0.93 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CHRNB1 | 0.05 | 0.04 | blup | 57 | 0.04 | 6.1e-05 | 5.5 | 6.3 | 2.4e-10 | 0.05 | 0.00 | 1.00 | TRUE |
| 20 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | EIF5A | 0.03 | 0.03 | blup | 52 | 0.03 | 4.2e-04 | -4.8 | -5.5 | 4.1e-08 | 0.02 | 0.02 | 0.96 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CHRNB1 | 0.18 | 0.09 | enet | 10 | 0.10 | 4.9e-11 | 5.7 | 5.3 | 1.4e-07 | 0.01 | 0.00 | 1.00 | FALSE |