Best TWAS P=3.12e-14 · Best GWAS P=1.05e-11 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CDK10 | 0.27 | 0.14 | lasso | 9 | 0.21 | 6.9e-25 | 6.46 | -5.2 | 1.6e-07 | -0.11 | 0.00 | 1.00 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | CTU2 | 0.10 | 0.07 | lasso | 5 | 0.08 | 4.0e-10 | -5.39 | 5.7 | 1.2e-08 | -0.43 | 0.94 | 0.06 | FALSE |
3 | GTEx | Adipose Subcutaneous | CHMP1A | 0.29 | 0.07 | enet | 35 | 0.12 | 2.0e-10 | 4.36 | 5.2 | 2.5e-07 | -0.07 | 0.23 | 0.56 | FALSE |
4 | GTEx | Adipose Subcutaneous | CDK10 | 0.37 | 0.20 | enet | 50 | 0.26 | 4.0e-21 | 1.49 | -5.5 | 3.1e-08 | -0.21 | 0.39 | 0.61 | FALSE |
5 | GTEx | Adipose Visceral Omentum | CDK10 | 0.43 | 0.19 | lasso | 6 | 0.32 | 3.6e-17 | 6.46 | -5.8 | 5.4e-09 | -0.19 | 0.00 | 1.00 | TRUE |
6 | GTEx | Adrenal Gland | URAHP | 0.22 | 0.04 | enet | 16 | 0.17 | 8.2e-07 | -3.67 | -5.4 | 6.1e-08 | 0.11 | 0.11 | 0.13 | TRUE |
7 | GTEx | Artery Aorta | VPS9D1 | 0.12 | 0.00 | enet | 21 | 0.06 | 5.0e-04 | 6.40 | 5.5 | 2.9e-08 | 0.03 | 0.03 | 0.71 | FALSE |
8 | GTEx | Artery Aorta | CHMP1A | 0.38 | 0.00 | enet | 32 | 0.30 | 1.2e-16 | -0.62 | 6.0 | 2.1e-09 | -0.03 | 0.08 | 0.35 | TRUE |
9 | GTEx | Artery Aorta | CDK10 | 0.33 | 0.07 | enet | 27 | 0.18 | 2.7e-10 | 6.41 | -6.0 | 2.5e-09 | -0.20 | 0.00 | 1.00 | FALSE |
10 | GTEx | Artery Tibial | CHMP1A | 0.21 | 0.06 | enet | 34 | 0.11 | 7.3e-09 | 4.36 | 6.5 | 7.3e-11 | -0.09 | 0.07 | 0.40 | TRUE |
11 | GTEx | Brain Cerebellar Hemisphere | CDK10 | 0.62 | 0.20 | enet | 33 | 0.28 | 6.4e-08 | 6.46 | -5.4 | 5.6e-08 | -0.21 | 0.00 | 1.00 | FALSE |
12 | GTEx | Brain Cortex | URAHP | 0.34 | 0.19 | enet | 15 | 0.17 | 2.4e-05 | -3.67 | -5.4 | 6.6e-08 | 0.15 | 0.38 | 0.13 | FALSE |
13 | GTEx | Cells Transformed fibroblasts | CHMP1A | 0.27 | 0.06 | enet | 23 | 0.11 | 7.0e-09 | 4.36 | 6.2 | 6.5e-10 | -0.02 | 0.65 | 0.14 | FALSE |
14 | GTEx | Cells Transformed fibroblasts | RP5-1142A6.9 | 0.08 | 0.07 | lasso | 4 | 0.06 | 2.6e-05 | -5.36 | 5.4 | 7.7e-08 | -0.40 | 0.70 | 0.23 | FALSE |
15 | GTEx | Colon Sigmoid | CDK10 | 0.37 | 0.12 | lasso | 8 | 0.22 | 2.2e-08 | 6.46 | -7.1 | 1.7e-12 | -0.21 | 0.01 | 0.99 | FALSE |
16 | GTEx | Esophagus Gastroesophageal Junction | CDK10 | 0.38 | 0.28 | lasso | 4 | 0.29 | 5.6e-11 | 6.41 | -6.8 | 7.6e-12 | -0.13 | 0.00 | 1.00 | FALSE |
17 | GTEx | Esophagus Mucosa | CDK10 | 0.36 | 0.15 | lasso | 6 | 0.23 | 1.9e-15 | 6.46 | -5.7 | 1.4e-08 | -0.18 | 0.00 | 1.00 | FALSE |
18 | GTEx | Esophagus Muscularis | CHMP1A | 0.15 | 0.01 | enet | 32 | 0.09 | 6.6e-06 | -2.30 | 5.7 | 1.5e-08 | -0.11 | 0.06 | 0.17 | FALSE |
19 | GTEx | Esophagus Muscularis | CDK10 | 0.24 | 0.11 | enet | 19 | 0.14 | 4.3e-09 | 6.46 | -7.6 | 3.1e-14 | -0.21 | 0.00 | 1.00 | TRUE |
20 | GTEx | Heart Atrial Appendage | CDK10 | 0.26 | 0.07 | lasso | 3 | 0.13 | 1.4e-06 | -2.92 | -5.3 | 8.7e-08 | -0.21 | 0.01 | 0.97 | FALSE |
21 | GTEx | Lung | SPIRE2 | 0.17 | 0.01 | enet | 24 | 0.04 | 7.7e-04 | 4.39 | -5.2 | 2.1e-07 | -0.05 | 0.02 | 0.97 | FALSE |
22 | GTEx | Muscle Skeletal | CDK10 | 0.17 | 0.12 | lasso | 6 | 0.10 | 9.2e-10 | 6.46 | -6.8 | 9.2e-12 | -0.17 | 0.00 | 1.00 | FALSE |
23 | GTEx | Nerve Tibial | CDK10 | 0.42 | 0.28 | enet | 16 | 0.35 | 1.2e-25 | 1.49 | -5.1 | 2.7e-07 | -0.22 | 0.72 | 0.28 | FALSE |
24 | GTEx | Ovary | CDK10 | 0.45 | 0.11 | lasso | 8 | 0.25 | 6.8e-07 | 6.46 | -5.7 | 1.1e-08 | -0.19 | 0.01 | 0.97 | TRUE |
25 | GTEx | Pituitary | VPS9D1-AS1 | 0.21 | -0.01 | lasso | 9 | -0.01 | 5.7e-01 | 6.46 | 6.6 | 4.5e-11 | 0.15 | 0.03 | 0.56 | FALSE |
26 | GTEx | Prostate | CDK10 | 0.41 | 0.16 | lasso | 6 | 0.24 | 1.0e-06 | 6.46 | -5.6 | 2.3e-08 | -0.19 | 0.00 | 0.97 | FALSE |
27 | GTEx | Skin Not Sun Exposed Suprapubic | CHMP1A | 0.25 | 0.01 | enet | 21 | 0.08 | 5.3e-05 | 4.36 | 7.4 | 1.6e-13 | 0.09 | 0.10 | 0.81 | FALSE |
28 | GTEx | Skin Sun Exposed Lower leg | VPS9D1 | 0.24 | 0.13 | lasso | 6 | 0.15 | 3.4e-12 | 3.49 | 5.6 | 2.1e-08 | 0.07 | 0.19 | 0.81 | FALSE |
29 | GTEx | Skin Sun Exposed Lower leg | CHMP1A | 0.36 | 0.11 | enet | 29 | 0.19 | 1.5e-15 | 4.36 | 6.5 | 9.2e-11 | 0.09 | 0.98 | 0.02 | FALSE |
30 | GTEx | Skin Sun Exposed Lower leg | CDK10 | 0.30 | 0.18 | enet | 18 | 0.29 | 3.0e-24 | 6.46 | -5.6 | 1.8e-08 | -0.19 | 0.00 | 1.00 | FALSE |
31 | GTEx | Skin Sun Exposed Lower leg | VPS9D1-AS1 | 0.18 | 0.04 | lasso | 5 | 0.06 | 1.2e-05 | 4.39 | 6.4 | 1.5e-10 | 0.07 | 0.01 | 0.99 | FALSE |
32 | GTEx | Small Intestine Terminal Ileum | VPS9D1 | 0.34 | 0.04 | enet | 11 | 0.11 | 2.4e-03 | 6.46 | 6.8 | 1.3e-11 | 0.16 | 0.01 | 0.93 | FALSE |
33 | GTEx | Stomach | CDK10 | 0.35 | 0.12 | enet | 12 | 0.22 | 6.4e-11 | 6.41 | -5.8 | 5.0e-09 | -0.20 | 0.00 | 1.00 | TRUE |
34 | GTEx | Testis | RP5-1142A6.2 | 0.21 | 0.13 | lasso | 4 | 0.12 | 7.2e-06 | -6.08 | -6.4 | 1.6e-10 | 0.60 | 0.01 | 0.94 | TRUE |
35 | GTEx | Thyroid | RPL13 | 0.13 | 0.05 | enet | 10 | 0.06 | 1.4e-05 | 4.28 | -5.3 | 9.9e-08 | -0.02 | 0.98 | 0.01 | TRUE |
36 | METSIM | Adipose | CHMP1A | 0.27 | 0.05 | lasso | 9 | 0.07 | 1.3e-10 | 4.36 | 7.0 | 2.6e-12 | 0.02 | 0.18 | 0.80 | FALSE |
37 | METSIM | Adipose | RP11-368I7.4 | 0.04 | 0.03 | enet | 12 | 0.02 | 2.2e-04 | 6.46 | 6.1 | 1.0e-09 | 0.17 | 0.00 | 1.00 | FALSE |
38 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CHMP1A | 0.07 | 0.02 | blup | 38 | 0.05 | 3.5e-06 | -2.62 | 5.6 | 2.4e-08 | 0.02 | 0.33 | 0.24 | FALSE |
39 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CHMP1A | 0.18 | 0.01 | enet | 11 | 0.06 | 3.8e-04 | 4.36 | 5.4 | 5.3e-08 | 0.03 | 0.06 | 0.14 | FALSE |
40 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CHMP1A | 0.07 | 0.03 | blup | 37 | 0.03 | 1.3e-04 | 4.36 | 6.6 | 3.2e-11 | 0.04 | 0.12 | 0.70 | FALSE |
41 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CDK10 | 0.20 | 0.02 | enet | 15 | 0.08 | 5.3e-04 | 4.36 | -6.0 | 2.1e-09 | -0.08 | 0.00 | 0.16 | FALSE |
42 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DBNDD1 | 0.25 | 0.00 | blup | 65 | 0.06 | 1.1e-06 | 5.49 | -5.3 | 1.4e-07 | -0.01 | 0.01 | 0.14 | FALSE |
43 | The Cancer Genome Atlas | Thyroid Carcinoma | CHMP1A | 0.11 | 0.09 | blup | 38 | 0.08 | 5.1e-08 | -2.62 | 5.3 | 1.0e-07 | 0.05 | 0.79 | 0.16 | FALSE |
44 | The Cancer Genome Atlas | Thyroid Carcinoma | DBNDD1 | 0.17 | 0.00 | blup | 66 | 0.04 | 6.6e-05 | -2.63 | -5.9 | 3.7e-09 | 0.05 | 0.04 | 0.11 | TRUE |