Hub : Genes

AC016722.2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.357	0.1180	5.3e-03	0.187	NA	0.165	NA	0.186	4.6e-06	NA	1.8e-05	NA	4.9e-06
2	GTEx	Brain Cerebellum	0.330	0.0880	4.7e-04	0.001	NA	0.012	NA	0.028	2.9e-01	NA	1.3e-01	NA	5.0e-02
3	GTEx	Brain Nucleus accumbens basal ganglia	0.483	0.1280	2.8e-03	0.179	NA	0.096	NA	0.135	1.6e-05	NA	1.5e-03	NA	1.9e-04
4	GTEx	Esophagus Gastroesophageal Junction	0.305	0.0840	1.6e-04	0.072	NA	0.085	NA	0.112	1.4e-03	NA	5.5e-04	NA	7.7e-05
5	ROSMAP	Brain Pre-frontal Cortex	0.127	0.0332	3.6e-06	0.016	0.058	0.064	0.06	0.048	3.3e-03	5.3e-08	1.3e-08	3.5e-08	7.4e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.6	0.9	2.6	-0.9	-0.3	-1.0	0.2	1.6
Bipolar Disorder or Schizophrenia	0.4	1.0	3.5	-0.2	-0.9	-0.5	0.7	1.9
Depressed Affect (Nagel 2018)	0.2	0.5	1.0	0.6	-1.0	0.8	-0.3	0.6
Depression (Nagel 2018)	0.1	0.2	1.0	0.2	-1.0	-0.1	0.1	0.1
Intelligence (Savage-Jansen 2018)	1.4	4.2	8.1	-1.6	-2.8	-1.7	2.5	-1.2
Neuroticism (Nagel 2018)	0.3	0.7	2.2	-0.6	-1.5	-0.3	0.4	0.8
Schizophrenia (2018)	0.3	0.6	1.4	0.6	-0.9	0.2	0.7	1.2
Schizophrenia vs Biploar Disorder	0.7	1.0	2.2	1.0	-0.0	1.0	1.5	0.8
Worry (Nagel 2018)	1.0	2.0	3.2	-1.8	-1.8	-1.7	0.4	0.9
Alzheimer’s Disease (in mother)	0.4	0.5	1.9	-0.2	0.7	-0.1	-0.3	1.4
Alzheimer’s Disease (in father)	0.2	0.3	0.7	0.8	0.2	0.6	0.3	-0.3
Alzheimer’s Disease (including proxy)	0.7	1.1	2.7	0.4	1.5	0.5	-0.3	1.6
Crohns Disease (2017)	0.5	1.1	1.8	1.3	1.0	1.1	-1.4	0.4
Irritable Bowel Disease (IBD)	0.5	1.1	5.1	-0.1	0.4	-0.4	-2.2	-0.0
Ulcerative Colitis (UC)	0.8	1.6	5.8	-0.8	-0.1	-1.2	-2.4	-0.3
Major Depression (MDD)	1.8	2.2	4.6	-2.0	0.6	-2.2	-1.4	-0.5
Reaction Time	0.3	0.5	1.1	0.7	0.7	0.8	1.0	-0.1
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.5	-0.8	-1.9	-0.9	1.4	-1.2
Breast Cancer	0.2	0.4	1.3	-0.3	-1.1	-0.3	-0.8	-0.2
Ovarian Cancer	0.1	0.2	0.3	0.4	0.4	0.1	-0.6	-0.4
Prostate Cancer	0.8	1.1	4.4	-0.0	0.5	-0.1	0.9	-2.1
Age at First Birth	0.1	0.1	0.2	-0.5	0.4	-0.3	-0.1	0.1
Bipolar Disorder (2011)	1.1	1.0	3.3	1.0	-0.3	0.9	0.2	1.8
Body Mass Index (BMI) (2010)	0.5	0.7	1.5	1.2	0.0	1.2	0.4	0.6
Coronary Artery Disease (CAD)	0.7	0.8	1.4	-1.2	-0.4	-1.1	-0.6	-0.9
Crohns Disease (2012)	0.3	0.4	1.1	0.7	-0.1	0.7	0.1	1.1
Mean Putamen Volume	0.2	0.2	0.5	0.0	-0.1	-0.4	-0.7	-0.5
Fasting Glucose	0.7	0.8	2.0	1.1	0.9	1.4	-0.4	0.1
HbA1C	1.5	1.6	3.7	1.0	1.9	1.2	-1.0	1.0
HDL Cholesterol	0.4	0.7	1.3	-0.7	-1.1	-0.9	0.7	-0.3
LDL Cholesterol	0.2	0.3	1.0	0.4	0.7	0.3	1.0	-0.1
Lupus	0.4	0.6	1.6	0.6	1.3	1.0	0.6	0.2
Neuroticism (2016)	0.5	0.8	2.2	-0.4	-1.5	-0.6	1.0	0.0
Primary Biliary Cirrhosis	0.1	0.2	0.5	0.7	0.1	0.5	0.1	0.3
Rheumatoid Arthritis	0.3	0.5	2.0	0.3	-1.4	0.4	0.3	-0.2
Schizophrenia (2014)	0.2	0.4	1.5	0.4	-0.0	0.1	0.7	1.2
Triglycerides	0.2	0.3	0.5	-0.0	-0.7	0.1	0.7	-0.5
Type 2 Diabetes (T2D) (2012)	0.9	1.1	4.7	-0.0	-0.8	0.2	2.2	0.3
Ulcerative Colitis	1.4	2.1	3.8	-1.6	-0.2	-2.0	-1.7	-1.0
Blood Eosinophil Count	0.7	5.7	10.2	-2.5	-1.8	-2.6	-1.3	-3.2
Blood Platelet Count	0.2	2.8	5.5	2.0	1.2	2.3	1.0	-1.4
Blood Red Count	0.7	7.1	15.3	-2.8	-2.1	-3.9	-0.7	-2.7
Blood White Count	0.7	5.4	19.9	1.8	-0.8	1.8	4.5	0.6
Heel T-Score	0.1	1.1	5.1	0.1	0.3	0.2	2.3	-0.6
BMI	1.1	6.2	9.7	3.1	1.4	3.1	3.1	-0.7
Height	1.4	26.6	102.0	-3.0	-2.1	-3.7	-10.1	2.1
Waist Hip Ratio (WHR)	1.8	8.0	11.9	-3.3	-2.8	-3.5	-2.1	-2.2
Systolic Blood Pressure	0.1	0.6	1.5	0.3	0.8	0.4	-1.2	0.9
Smoking Status	0.3	0.8	3.6	-0.3	-0.6	-0.3	-1.9	-0.0
Allergy or Eczema	1.0	2.7	7.2	-0.7	1.9	-0.8	-2.7	1.1
Cardiovascular Disease	0.2	0.5	1.1	1.1	0.0	0.9	0.6	0.6
Hypothyroidism (self reported)	0.2	0.5	1.0	-1.0	0.0	-1.0	0.7	-0.5
Respiratory disease	0.2	0.4	0.8	-0.7	0.1	-0.7	-0.5	-0.9
Type 2 Diabetes (T2D) (2018)	0.9	1.7	2.5	1.6	-0.1	1.3	1.3	1.6
Lung FEV1/FVC ratio	1.9	9.6	24.2	2.7	0.5	3.1	4.9	2.5
Lung FVC	1.0	5.2	11.2	-3.3	-0.8	-3.4	-1.1	-1.4
Neuroticism	1.0	2.5	4.9	-1.9	-2.2	-1.9	-0.7	0.5
Chronotype (morning person)	0.7	1.6	3.0	1.2	-1.4	1.1	1.7	0.6
Hair Pigment	0.0	0.9	2.3	0.3	0.3	0.4	-1.4	-1.5
Tanning	0.1	1.8	5.4	0.7	1.4	0.7	0.6	2.3
Hand grip strength (left)	0.9	2.4	10.6	-0.4	0.4	-0.7	-3.3	0.7
Number of treatments/medications taken	0.7	1.2	5.5	-0.4	0.1	-0.5	-2.4	0.3
Average weekly spirits intake	0.6	0.7	2.8	-0.3	1.7	-0.4	0.4	-0.7
Sensitivity / hurt feelings	2.0	3.4	7.7	-2.0	-2.8	-1.8	1.2	0.3
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.5	-0.5	-0.7	-0.4	-0.2	-0.2
Hearing difficulty/problems: Yes	0.7	1.1	1.5	1.2	-0.4	1.1	1.1	1.2
Relative age of first facial hair	1.8	3.8	8.8	-1.3	-2.0	-1.1	3.0	-1.8
Other serious medical condition/disability diagnosed by doctor	1.3	1.6	3.1	-1.7	-1.2	-1.8	-0.4	-0.7
Ever used hormone-replacement therapy (HRT)	1.4	1.8	3.3	-1.6	-1.8	-1.6	0.7	-0.1
Ever had hysterectomy (womb removed)	0.4	0.5	0.7	0.8	0.6	0.7	-0.3	0.9
Systolic blood pressure, automated reading	0.2	0.5	1.5	-0.6	1.2	-0.2	-0.7	0.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.5	0.6	-0.2	0.4	0.3	-0.7
Angina	0.1	0.1	0.2	0.2	-0.4	0.5	0.2	0.4
Medication for hormone replacement therapy	0.3	0.4	1.2	-0.3	-1.1	-0.5	-0.3	0.4
Vitamin and mineral supplements	2.9	3.9	7.0	1.8	1.0	2.0	2.6	2.0
Supplements: Zinc	4.8	5.3	8.1	-2.6	-2.1	-2.8	-1.2	-2.4
Medication: Co-codamol	0.4	0.4	1.1	0.2	-0.6	0.5	1.1	-0.6
Medication: Metformin	0.1	0.1	0.2	-0.3	0.5	-0.1	-0.1	-0.3
Diabetes (father)	0.7	0.9	3.2	0.7	-0.6	0.6	1.8	0.2
Diabetes (mother)	0.1	0.2	0.6	-0.1	-0.3	0.1	0.8	0.3
Severe depression (siblings)	0.7	0.7	2.5	-0.6	0.5	-0.5	-1.6	0.6
Pack years adult smoking proportion	2.0	3.0	4.8	1.9	2.2	1.8	-0.2	1.8
Impedance of leg (right)	0.5	2.4	5.9	-2.4	0.9	-2.0	0.9	0.8
Leg fat-free mass (left)	0.5	2.8	12.2	0.9	-0.6	0.6	-3.5	-0.5
Trunk fat percentage	0.2	0.7	1.6	0.4	1.3	0.7	0.8	-0.7
Hand grip strength (right)	0.6	1.5	6.6	-0.2	0.1	-0.4	-2.6	1.0
Townsend deprivation index at recruitment	0.1	0.1	0.6	-0.1	0.2	0.1	-0.1	0.7
Current tobacco smoking	0.2	0.4	0.9	0.3	0.7	0.7	-1.0	-0.2
Average weekly fortified wine intake	1.2	1.4	2.6	-1.6	0.2	-1.6	-1.2	-0.7
Maternal smoking around birth	0.5	0.7	2.4	-0.2	0.9	0.1	1.5	0.4
Fed-up feelings	0.4	0.8	2.5	0.6	-1.6	0.8	-0.0	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.4	0.6	-1.2	0.5	-0.4	0.6
Relative age voice broke	1.6	2.4	3.7	-1.8	-1.3	-1.9	1.4	-1.1
Taking other prescription medications	0.5	0.7	2.3	-0.6	-0.0	-0.7	-1.5	-0.6
Age when periods started (menarche)	0.3	0.7	2.0	-1.1	-0.5	-1.4	-0.5	-0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.1	-0.2	-1.0	-0.3	-0.7	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.0	1.0	0.2	0.9	1.4	0.1
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	3.9	-2.0	-1.1	-1.9	0.9	-0.3
Qualifications: CSEs or equivalent	0.3	0.4	1.2	0.0	-0.9	0.0	1.1	0.4
Serious illness, injury or assault to yourself	0.3	0.4	0.5	-0.6	0.6	-0.5	-0.7	-0.6
High blood pressure	0.2	0.5	0.8	0.8	-0.0	0.8	0.9	0.7
Hayfever, allergic rhinitis or eczema	1.2	2.6	7.5	-0.5	1.9	-0.7	-2.7	1.0
Multivitamins +/- minerals	3.9	5.0	7.7	-2.3	-1.4	-2.1	-2.8	-2.4
Stomach or abdominal pain in last month	0.6	0.7	2.3	-0.4	-0.8	-0.2	0.8	-1.5
Supplements: Glucosamine	3.2	4.2	7.2	-2.1	-1.2	-2.7	-2.0	-1.9
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.0	-1.0	-0.6	-0.6	-0.3	-0.6
Medication: Atenolol	1.1	1.3	3.2	-1.2	-1.8	-1.1	0.0	-0.7
Medication: Levothyroxine sodium	2.0	3.4	6.1	-2.2	-1.2	-2.5	-1.3	-1.6
Sitting height	1.4	9.8	36.0	-2.0	-1.6	-2.3	-6.0	-1.1
Chronic bronchitis/emphysema (father)	0.5	0.6	1.8	-0.6	-0.8	-0.5	0.1	-1.3
High blood pressure (mother)	1.0	1.4	4.0	-0.1	-2.0	-0.2	1.3	-1.1
Body mass index (BMI)	0.7	2.9	5.6	2.1	1.7	2.4	1.1	-0.5
Impedance of leg (left)	0.6	3.0	7.7	-2.8	0.5	-2.4	0.8	0.8
Leg predicted mass (left)	0.5	2.9	12.5	1.0	-0.4	0.7	-3.5	-0.5
Trunk fat mass	0.2	0.7	1.4	0.7	1.2	0.9	-0.8	-0.4
Waist circumference	0.2	0.8	2.0	1.1	0.7	1.4	-0.7	-0.0
Number of incorrect matches in round	2.8	4.7	9.5	1.6	2.9	1.8	0.0	3.1
Past tobacco smoking	0.6	1.1	2.4	-1.3	0.3	-0.9	0.7	-1.5
Alcohol usually taken with meals	0.9	1.4	3.9	-0.3	2.0	-0.2	-1.0	1.4
Nervous feelings	0.6	1.1	2.5	0.5	-0.9	0.6	1.6	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.9	-1.3	-0.1	-1.2	-1.7	-0.7
Hearing difficulty/problems with background noise	0.7	1.1	1.8	1.0	-1.3	0.9	0.5	1.4
Hair/balding pattern: Pattern 2	1.1	1.4	2.6	-1.0	-1.2	-0.9	1.0	-1.6
Had menopause	0.3	0.3	1.4	0.2	0.3	0.2	0.1	-1.2
Had other major operations	2.2	2.7	5.4	-2.2	-1.5	-2.3	-0.2	-1.0
Forced vital capacity (FVC)	1.9	7.2	11.8	-3.1	-1.7	-3.4	-3.4	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	3.4	-0.6	-1.8	-0.7	1.6	-1.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.5	-1.2	0.3	-1.1	-0.2	-0.2
Qualifications: None of the above	0.2	0.5	1.6	-0.3	1.3	-0.2	-0.5	-0.6
Financial difficulties in last 2 years	0.7	0.9	1.9	1.2	0.9	1.4	0.4	0.5
Mouth/teeth dental problems	1.9	3.0	7.0	-2.6	-0.7	-2.4	0.8	-1.0
Heart attack	0.3	0.4	1.0	-0.4	0.3	-0.4	-1.0	-0.8
Allergy	0.7	1.7	2.8	1.2	-1.5	1.3	1.7	0.4
Pain all over the body in last month	1.8	1.9	3.5	1.9	0.9	1.9	-1.0	0.9
Diabetes (self-reported)	0.7	1.0	2.7	1.2	0.2	0.8	0.5	1.6
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.4	-0.4	-0.2	-0.5	-1.5	1.2
Medication: Ramipril	0.4	0.6	1.0	-0.8	1.0	-0.6	-0.7	-0.6
Medication: Simvastatin	0.5	0.7	1.3	0.8	1.1	0.9	0.2	0.7
Fluid intelligence score	0.7	1.4	2.0	-1.1	-1.4	-1.4	-0.4	-1.2
Illnesses of siblings	0.2	0.2	0.6	0.3	0.3	-0.0	0.6	0.8
Neuroticism score	0.7	1.5	5.6	-0.8	-2.4	-0.7	-0.1	0.8
Weight	0.4	1.8	6.9	0.9	0.7	0.9	-2.6	-0.2
Impedance of arm (right)	0.4	2.1	5.6	-2.4	-0.4	-2.1	0.3	0.1
Arm fat percentage (right)	0.6	2.3	4.2	1.6	2.1	1.9	1.1	-0.4
Trunk fat-free mass	1.1	6.0	28.9	0.9	-0.2	0.4	-5.4	0.5
Hip circumference	0.9	3.9	7.6	2.5	1.9	2.8	-0.6	1.1
Time employed in main current job	0.4	0.5	1.0	-1.0	0.4	-0.9	0.1	-0.6
Alcohol intake versus 10 years previously	0.2	0.4	1.2	-0.4	-1.1	-0.6	0.4	-0.2
Father’s age at death	1.3	1.7	3.1	1.6	1.3	1.8	0.0	1.1
Worrier / anxious feelings	1.1	2.1	4.6	-1.8	-2.1	-1.6	0.1	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.1	0.5	-0.2	0.4	-1.1	-0.3
Falls in the last year	0.4	0.5	1.0	0.6	1.0	0.6	1.0	0.3
Hair/balding pattern: Pattern 3	3.5	5.1	8.1	2.7	1.9	2.9	1.1	2.3
Number of live births	0.5	0.7	1.9	0.0	-1.1	-0.2	1.4	-0.3
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	5.4	-2.1	-1.4	-2.3	-1.3	-0.3
Pulse rate	1.3	2.3	3.4	1.8	1.8	1.8	0.9	0.7
Happiness	0.8	0.9	2.6	-0.8	-0.1	-0.7	-1.6	0.9
Noisy workplace	0.6	0.7	2.5	-0.3	1.0	0.1	-0.1	1.6
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.6	-0.5	-0.7	-0.8	0.8	-1.9
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	4.2	-1.3	-0.0	-1.5	-2.0	-1.8
Mouth/teeth dental problems: Dentures	1.2	2.0	4.2	2.0	-1.2	1.6	1.0	-0.8
Asthma	0.5	1.0	1.6	-1.3	-0.5	-1.2	0.2	-1.2
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.8	1.2	0.8	1.2	-1.7	-0.8
Medication: Cholesterol lowering	0.1	0.2	0.3	0.6	0.5	0.3	-0.5	0.0
Depression (self-reported)	0.1	0.1	0.5	0.3	-0.7	0.2	0.1	-0.0
Medication: Lansoprazole	0.6	0.7	1.2	-1.1	-0.7	-0.8	-0.5	-0.8
Prospective memory result	0.6	0.8	1.9	-1.0	-0.7	-1.4	0.5	-0.0
Lung cancer (father)	0.4	0.5	1.4	0.4	1.2	0.6	0.0	-0.7
Illnesses of mother	0.3	0.4	0.6	0.6	0.8	0.5	-0.8	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	5.5	-1.9	-1.1	-2.3	-1.3	-0.4
Pulse wave Arterial Stiffness index	0.3	0.3	1.0	-0.0	0.7	0.1	0.1	-1.0
Impedance of arm (left)	0.6	2.7	6.6	-2.6	-0.9	-2.3	0.7	-0.2
Arm fat mass (right)	0.4	1.7	3.2	1.6	1.6	1.8	-0.2	-0.2
Trunk predicted mass	1.0	6.0	28.4	0.9	-0.2	0.5	-5.3	0.6
Standing height	1.7	16.9	64.0	-2.6	-1.9	-3.1	-8.0	0.4
Length of working week for main job	0.5	0.5	1.2	1.1	-0.5	0.8	-0.6	-0.3
Exposure to tobacco smoke at home	0.4	0.5	1.6	-0.2	-1.2	-0.4	0.4	0.7
Breastfed as a baby	0.0	0.1	0.2	0.0	-0.0	-0.4	0.3	-0.0
Tense / ‘highly strung’	1.4	2.3	3.7	-1.8	-1.9	-1.6	-0.7	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.6	-0.8	-1.6	-0.5	-0.8	0.8
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	-0.1	-0.7	-0.1	-0.3	0.7
Birth weight of first child	3.5	6.3	10.9	-2.8	-2.3	-3.3	-2.4	-1.4
Peak expiratory flow (PEF)	1.2	2.9	5.6	-2.2	-1.7	-2.4	-0.0	-1.1
Pulse wave reflection index	0.2	0.2	0.7	0.2	0.8	0.2	0.1	0.7
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.9	0.1	1.0	0.2	0.5	0.1
Loud music exposure frequency	0.6	0.7	2.2	0.1	-1.5	0.2	0.7	0.8
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	2.3	-1.5	-1.3	-1.5	0.5	-1.2
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.6	1.0	1.2	1.0	-0.1	1.6
Blood clot in the leg (DVT)	2.9	3.7	6.4	-2.5	-0.7	-2.2	0.6	-2.5
Medication: Paracetamol	0.5	0.8	2.7	-0.3	0.8	-0.1	-0.9	-1.6
Headache pain in last month	0.4	0.7	3.1	-0.3	0.6	0.1	-0.0	-1.8
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.7	-0.8	-0.1	-0.4	-0.0	-0.4
Glaucoma (self-reported)	0.5	0.6	1.1	1.0	-0.4	1.1	-0.4	0.9
Gout (self-reported)	0.2	0.3	0.3	0.5	0.6	0.5	-0.6	0.5
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	3.6	-1.8	-0.8	-1.9	-0.5	-0.9
Medication: Amlodipine	1.3	1.8	3.0	1.7	1.4	1.6	-0.4	1.2
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.7	0.3	-0.8	0.4	0.3	-0.5
Birth weight	2.4	5.1	18.8	-0.5	2.0	-0.6	-4.3	1.4
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.8	0.2	1.7	0.2	0.1	0.9
High blood pressure (siblings)	0.3	0.4	1.2	0.2	1.1	0.5	-0.8	0.3
Forced vital capacity (FVC), Best measure	1.5	5.4	10.1	-2.7	-1.4	-3.2	-2.8	-0.5
Body fat percentage	0.4	1.6	3.7	0.9	1.9	1.3	1.2	-0.4
Leg fat percentage (right)	0.7	2.6	6.0	1.2	2.4	1.7	1.6	-0.3
Arm fat-free mass (right)	0.6	3.3	14.4	1.1	-0.4	0.7	-3.8	0.4
Exposure to tobacco smoke outside home	0.3	0.4	0.6	0.7	0.2	0.8	0.8	-0.1
Comparative body size at age 10	0.4	1.1	3.4	0.6	1.8	0.9	-0.8	0.4
Number of full brothers	0.6	0.8	1.8	0.4	-1.1	0.5	1.3	0.6
Worry too long after embarrassment	1.3	2.3	4.0	-1.4	-1.8	-1.2	0.8	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	4.1	0.9	-0.9	0.8	0.5	2.0
Wheeze or whistling in the chest in last year	1.4	2.4	3.1	-1.8	-1.1	-1.6	-1.6	-1.7
Number of children fathered	1.0	1.1	3.2	0.8	1.8	0.7	0.9	0.6
Reason for reducing amount of alcohol drunk: Health precaution	3.1	3.6	6.4	-2.1	-2.5	-2.3	-0.6	-1.2
Age at first live birth	0.1	0.2	0.7	0.1	0.0	0.3	0.2	-0.8
Pulse wave peak to peak time	0.3	0.4	0.8	-0.0	-0.8	-0.2	-0.6	0.9
Health satisfaction	0.2	0.3	1.1	0.0	-0.5	0.3	1.1	0.3
Shortness of breath walking on level ground	0.7	0.9	2.9	0.0	-1.2	0.2	1.7	0.0
Qualifications: College or University degree	0.8	2.4	5.2	-1.8	-2.3	-1.7	0.9	0.4
Eye problems/disorders: None of the above	0.9	1.1	2.8	-1.7	0.0	-1.6	-0.0	-0.2
Mouth/teeth dental problems: Loose teeth	1.0	1.1	1.9	1.2	1.1	1.4	1.0	0.4
Emphysema/chronic bronchitis	1.7	1.9	4.3	1.2	-1.1	1.5	2.1	0.6
Medication for pain relief, constipation, heartburn	0.5	0.8	1.2	-0.9	-0.5	-1.1	0.8	1.0
Neck or shoulder pain in last month	0.1	0.2	0.2	0.5	0.4	0.4	-0.4	-0.1
Medication: Blood pressure	0.2	0.3	0.6	0.7	0.1	0.5	0.7	0.3
Angina (self-reported)	0.1	0.1	0.3	-0.0	-0.4	0.4	-0.0	0.5
Migraine (self-reported)	1.3	1.6	2.7	-1.6	-0.5	-1.6	-0.3	-1.6
Medication: Ibuprofen	0.6	0.8	1.5	1.2	0.2	1.2	-0.9	-0.3
Medication: Allopurinol	0.3	0.4	1.2	0.5	1.1	0.3	-0.6	-0.4
Medication: Omeprazole	0.3	0.4	0.7	-0.7	-0.9	-0.5	-0.5	-0.5
Medication: Seretide 50 evohaler	1.8	2.1	3.9	-2.0	-0.6	-1.7	-0.1	-1.7
Mean time to correctly identify matches	0.5	1.0	1.6	0.9	1.3	1.1	1.1	-0.3
Heart disease (mother)	0.9	1.1	2.2	-0.9	-1.3	-0.8	-0.6	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.1	-0.5	1.0	-0.4	0.8	-0.3
Whole body fat mass	0.3	1.1	2.2	1.1	1.5	1.4	-0.4	-0.3
Leg fat mass (right)	0.4	1.7	3.3	1.4	1.8	1.7	0.3	-0.3
Arm predicted mass (right)	0.6	3.2	14.9	0.8	-0.3	0.4	-3.9	0.1
Pulse rate, automated reading	0.3	0.9	1.7	0.8	0.4	0.9	1.3	-1.1
Alcohol intake frequency.	0.5	1.2	3.4	0.9	-0.7	1.1	1.8	-0.3
Comparative height size at age 10	1.7	9.3	42.2	0.1	0.0	0.1	-6.5	2.1
Number of full sisters	1.5	1.8	2.5	-1.3	-1.5	-1.3	1.6	-1.0
Suffer from ‘nerves’	0.3	0.4	1.6	0.0	-1.3	-0.0	0.6	0.5
Overall health rating	1.5	3.2	5.9	2.2	1.0	2.4	0.7	1.9
Chest pain or discomfort	0.1	0.1	0.4	0.1	-0.1	0.3	0.6	-0.0
Had major operations	1.2	1.4	3.1	-1.3	0.7	-1.3	-1.8	0.0
Age at last live birth	0.6	0.8	3.2	-0.4	-1.8	-0.3	0.2	-0.7
Family relationship satisfaction	0.5	0.6	1.9	0.8	0.0	0.4	0.7	1.4
Leg pain on walking	0.6	0.8	1.4	-0.9	-0.9	-0.7	1.2	-0.6
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	4.0	0.7	-0.4	1.0	2.0	0.5
Commuting to job workplace: Car/motor vehicle	2.1	2.4	6.9	1.0	2.6	0.9	-0.9	1.6
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	6.1	-0.9	-2.5	-0.6	1.3	0.1
Medication: Aspirin	0.8	1.1	2.0	1.4	1.0	1.4	-0.2	-0.5
Supplements: Vitamin C	0.1	0.1	0.1	-0.1	0.2	-0.3	0.4	-0.3
Knee pain experienced in last month	1.2	1.9	4.5	-0.7	-2.1	-0.8	0.9	-1.7
Hypertension (Self-reported)	0.4	1.0	1.5	1.2	0.2	1.2	1.1	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	-0.6	-0.6	-0.5	0.5	0.1
Illnesses of father: Heart disease	0.8	1.1	2.9	-0.4	-1.5	-0.5	0.1	-1.7
Illnesses of siblings: Diabetes	0.5	0.6	2.1	0.1	-0.6	0.4	1.4	0.8
Smoking status: Previous	0.7	1.0	2.2	0.9	-1.1	0.4	-1.0	1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.7	-0.3	-1.0	-0.2	-1.3	0.3
Whole body fat-free mass	0.8	4.7	22.0	1.0	-0.3	0.6	-4.7	0.1
Leg fat-free mass (right)	0.6	3.0	13.6	0.8	-0.7	0.4	-3.7	-0.4
Arm fat percentage (left)	0.6	2.5	4.0	1.7	1.9	2.0	1.4	-0.4
Average weekly red wine intake	1.5	2.2	5.3	0.0	1.7	-0.1	-2.3	1.7
Handedness (chirality/laterality): Left-handed	1.4	1.7	3.1	1.8	1.1	1.6	0.9	0.7
Mood swings	0.9	1.6	2.2	1.3	0.6	1.4	-1.4	1.5
Loneliness, isolation	1.8	2.5	9.1	-1.1	-3.0	-1.3	-0.1	-0.6
Long-standing illness, disability or infirmity	0.2	0.3	1.5	0.0	0.3	0.2	-0.3	1.2
Ever had bowel cancer screening	0.1	0.1	0.1	0.1	-0.2	0.3	0.3	0.2
Diabetes diagnosed by doctor	1.0	1.7	2.6	1.6	0.3	1.3	1.2	1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	0.6	-0.3	0.5	-0.5	0.7
Friendships satisfaction	0.5	0.7	2.2	0.3	-0.0	-0.1	1.0	1.5
Qualifications: nursing, teaching	0.0	0.1	0.2	0.1	-0.3	0.1	0.4	0.3
Commuting to job workplace: Walk	0.4	0.4	1.6	0.2	-0.3	0.3	0.2	-1.3
Eye problems/disorders: Cataract	0.3	0.4	0.9	0.9	-0.0	0.8	0.4	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	2.9	-0.1	1.7	0.2	-1.5	1.5
Medication for cholesterol	1.1	1.6	4.5	-0.0	-1.3	0.0	2.1	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.8	0.3	0.5	-0.1	-0.9	0.4
Back pain experienced in last month	0.1	0.2	0.5	-0.0	0.7	0.2	-0.1	-0.7
Mineral and other dietary supplements	2.6	3.5	9.0	1.8	-0.4	2.1	3.0	0.7
Breast cancer (self-reported)	1.1	1.4	3.1	1.4	1.0	1.8	0.3	0.8
Asthma (self-reported)	0.7	1.3	2.2	-1.5	-0.4	-1.4	0.2	-1.4
Osteoporosis (self-reported)	1.0	1.2	2.5	-1.5	0.2	-1.6	0.0	-1.1
Osteoarthritis (self-reported)	0.6	0.8	1.1	-0.9	-0.7	-0.8	-1.0	-1.0
Medication: Aspirin	0.8	1.1	2.0	1.4	0.8	1.4	-0.5	-0.7
Medication: Gliclazide	0.6	0.7	1.3	0.7	1.1	0.8	-0.2	-1.1
Illnesses of father: None of the above (group 1)	0.5	0.6	1.0	-0.7	1.0	-0.5	-0.8	0.5
Smoking status: Current	0.2	0.4	1.2	-0.0	0.6	0.3	-1.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.6	-0.2	0.1	-0.5	0.8	0.2
Whole body water mass	0.8	4.5	20.9	1.0	-0.3	0.6	-4.6	0.1
Leg predicted mass (right)	0.5	2.9	13.0	0.8	-0.8	0.4	-3.6	-0.4
Arm fat mass (left)	0.3	1.4	2.9	1.5	1.3	1.7	0.0	-0.2
Number of self-reported non-cancer illnesses	0.8	1.3	2.9	-1.3	-0.2	-1.2	-1.7	-0.6
Average weekly champagne plus white wine intake	0.8	1.0	1.9	1.0	1.0	0.9	-1.4	0.8
Miserableness	0.4	0.7	1.6	1.1	0.7	1.3	-0.1	0.5
Guilty feelings	0.3	0.4	1.1	0.1	-1.0	0.0	-0.2	1.0
Wears glasses or contact lenses	0.5	0.6	2.2	0.6	-0.6	0.3	0.1	-1.5
Ever taken oral contraceptive pill	0.2	0.2	0.7	0.5	-0.2	0.4	0.8	0.2
Hearing aid user	1.1	1.2	2.6	-1.1	-0.9	-1.1	-0.2	-1.6
Mother’s age at death	0.7	0.9	3.9	-0.4	-2.0	-0.4	0.6	-0.1
Financial situation satisfaction	0.8	1.0	2.0	0.9	1.0	1.0	1.4	0.3
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.5	1.4	1.6	1.3	-1.0	0.7
Commuting to job workplace: Public transport	0.6	0.7	1.8	0.3	-1.4	0.1	0.2	-1.3
Eye problems/disorders: Glaucoma	0.2	0.3	0.9	0.4	-0.4	0.4	0.1	1.0
Medication: Blood pressure	0.3	0.5	1.3	-0.5	-0.0	-0.4	-0.9	1.1
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.6	-0.8	-0.0	-0.0	1.1	-1.3
Supplements: Fish oil (including cod liver oil)	1.5	2.0	7.1	-1.0	0.7	-1.1	-2.7	-0.1
High cholesterol (Self-reported)	0.6	1.1	1.9	0.8	1.4	0.8	-0.7	1.4
Medication: Bendroflumethiazide	0.3	0.5	1.0	1.0	0.5	0.9	-0.1	0.5
Medication: Paracetamol	0.1	0.2	0.4	0.2	0.5	0.2	-0.4	-0.6
Medication: Lisinopril	0.2	0.2	0.6	0.8	0.2	0.6	-0.0	0.5
Medication: Atorvastatin	0.1	0.2	0.4	-0.5	-0.7	-0.4	-0.2	0.0
Illnesses of father: High blood pressure	0.9	1.1	2.6	1.2	0.4	1.6	-0.2	1.2
Alcohol drinker status: Never	0.6	0.7	1.7	-0.6	-0.7	-0.8	-0.6	-1.3
Ever smoked	0.8	1.5	2.4	1.4	0.9	1.1	-1.0	1.6
Basal metabolic rate	0.7	3.9	17.9	1.0	-0.0	0.7	-4.2	0.1
Leg fat percentage (left)	0.7	2.5	5.0	1.2	2.2	1.8	1.6	-0.1
Arm fat-free mass (left)	0.7	3.3	14.9	1.0	0.1	0.7	-3.9	0.4
Number of operations (self-reported)	2.5	3.7	7.0	-2.4	-0.2	-2.6	-2.1	-1.0
Average weekly beer plus cider intake	0.4	0.5	1.5	0.4	-1.2	0.2	0.9	-0.2
Irritability	0.3	0.6	1.7	-0.3	-0.7	-0.1	-1.3	0.8
Risk taking	0.6	0.8	2.2	1.0	0.3	0.5	-0.9	1.5
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.7	0.8	0.7	0.8	-0.6	-0.1
Fractured/broken bones in last 5 years	0.4	0.5	0.9	0.5	0.8	0.2	-1.0	-0.8
Age started oral contraceptive pill	0.2	0.2	0.6	-0.5	0.1	-0.6	0.7	-0.2
Diastolic blood pressure, automated reading	0.0	0.1	0.3	-0.4	0.5	-0.2	0.5	0.0
Ever depressed for a whole week	0.7	0.9	1.7	-1.3	0.4	-1.1	-0.7	-0.9
Unable to work because of sickness or disability	2.6	3.4	6.0	2.4	1.5	2.5	1.4	0.9
Commuting to job workplace: Cycle	0.4	0.5	1.3	-0.5	-0.6	-0.7	0.5	1.1
Myopia	1.0	1.4	5.3	1.0	-0.1	1.0	2.3	0.1
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.5	-0.7	-0.4	-0.6	-0.2	-0.7
Cholesterol lowering medication	1.1	1.6	3.9	0.2	2.0	0.5	-0.7	1.8
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.7	-1.0	-0.5	-0.7	-1.3	0.1
Pain experienced in last month	0.2	0.4	1.7	-0.0	-0.0	-0.1	0.5	1.3
Supplements: Calcium	8.1	8.9	13.1	-3.5	-2.4	-3.6	-0.9	-3.6
Basal cell carcinoma (self-reported)	1.4	1.7	5.3	-0.3	-1.3	-0.3	2.3	-1.0
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.2	-0.6	0.1	-0.6	-1.1	-0.9
Deep venous thrombosis (DVT) (self-reported)	3.5	4.5	8.6	-2.9	-0.7	-2.7	0.3	-2.5
Heart disease (siblings)	0.6	0.7	2.5	0.3	0.6	0.2	-1.6	-0.7
Alcohol drinker status: Previous	1.3	1.5	2.0	1.2	1.3	1.4	-0.5	1.4
Pack years of smoking	1.5	2.2	3.4	1.7	1.9	1.6	-0.0	1.5
Impedance of whole body	0.6	3.0	7.8	-2.8	-0.1	-2.5	0.9	0.4
Leg fat mass (left)	0.4	1.6	3.0	1.5	1.7	1.7	0.2	-0.2
Arm predicted mass (left)	0.6	3.0	14.0	0.8	0.0	0.5	-3.7	0.3