Best TWAS P=1.62e-56 · Best GWAS P=4.47e-84 conditioned to 0.0289
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EFEMP1 | 0.31 | 0.08 | bslmm | 493 | 0.24 | 1.4e-28 | 2.822 | -5.3 | 1.3e-07 | 0.43 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Brain Frontal Cortex BA9 | EFEMP1 | 0.19 | 0.10 | lasso | 8 | 0.08 | 3.7e-03 | -15.646 | -15.8 | 1.6e-56 | 0.78 | 0.04 | 0.70 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | EFEMP1 | 0.11 | 0.00 | enet | 22 | 0.05 | 1.1e-04 | 0.066 | -9.6 | 1.1e-21 | 0.39 | 0.16 | 0.57 | TRUE |
| 4 | GTEx | Stomach | SMEK2 | 0.14 | 0.02 | enet | 19 | 0.04 | 3.9e-03 | -0.702 | -5.6 | 2.2e-08 | 0.08 | 0.10 | 0.04 | TRUE |
| 5 | GTEx | Whole Blood | RP11-554J4.1 | 0.13 | 0.03 | lasso | 5 | 0.03 | 6.4e-04 | -4.124 | -7.1 | 1.2e-12 | 0.08 | 0.16 | 0.13 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | EFEMP1 | 0.29 | 0.14 | enet | 37 | 0.19 | 2.2e-24 | -10.609 | -10.6 | 4.3e-26 | 0.64 | 1.00 | 0.00 | TRUE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | PNPT1 | 0.06 | 0.01 | blup | 464 | 0.01 | 1.1e-02 | 2.780 | 6.8 | 9.9e-12 | -0.12 | 0.76 | 0.01 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EFEMP1 | 0.02 | 0.01 | blup | 79 | 0.02 | 3.9e-05 | -19.428 | 8.9 | 4.2e-19 | -0.73 | 0.00 | 1.00 | FALSE |