Best TWAS P=2.56e-11 · Best GWAS P=2.02e-12 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | BAIAP2L2 | 0.11 | 0.03 | lasso | 5 | 0.04 | 1.8e-04 | 5.1 | -5.6 | 2.1e-08 | -0.75 | 0.12 | 0.50 | FALSE |
2 | GTEx | Cells EBV-transformed lymphocytes | PLA2G6 | 0.28 | 0.17 | enet | 13 | 0.18 | 1.3e-06 | -3.6 | 5.2 | 1.6e-07 | 0.70 | 0.06 | 0.91 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | PLA2G6 | 0.23 | 0.09 | lasso | 9 | 0.10 | 9.9e-08 | 6.7 | 6.4 | 2.1e-10 | 0.83 | 0.08 | 0.92 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | MAFF | 0.08 | 0.08 | lasso | 3 | 0.06 | 2.2e-05 | 5.6 | -5.4 | 5.8e-08 | -0.71 | 0.26 | 0.43 | FALSE |
5 | GTEx | Esophagus Mucosa | PLA2G6 | 0.22 | 0.02 | lasso | 6 | 0.04 | 1.9e-03 | 6.7 | 6.2 | 4.4e-10 | 0.80 | 0.02 | 0.97 | FALSE |
6 | GTEx | Nerve Tibial | PLA2G6 | 0.34 | 0.08 | lasso | 8 | 0.11 | 2.9e-08 | -3.6 | 5.5 | 3.7e-08 | 0.74 | 0.10 | 0.90 | FALSE |
7 | GTEx | Nerve Tibial | MAFF | 0.14 | 0.06 | lasso | 3 | 0.05 | 1.2e-04 | 7.0 | -6.7 | 2.6e-11 | -0.99 | 0.00 | 0.99 | TRUE |
8 | GTEx | Skin Sun Exposed Lower leg | BAIAP2L2 | 0.09 | 0.09 | lasso | 4 | 0.09 | 5.5e-08 | 6.2 | -6.6 | 5.7e-11 | -0.77 | 0.05 | 0.95 | FALSE |
9 | GTEx | Thyroid | TMEM184B | 0.19 | 0.16 | lasso | 7 | 0.18 | 1.0e-13 | 3.8 | -5.3 | 9.1e-08 | -0.66 | 0.54 | 0.46 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PLA2G6 | 0.05 | 0.01 | blup | 76 | 0.01 | 7.7e-02 | 6.5 | 5.9 | 4.1e-09 | 0.85 | 0.02 | 0.73 | FALSE |
11 | The Cancer Genome Atlas | Thyroid Carcinoma | PLA2G6 | 0.03 | 0.02 | lasso | 2 | 0.03 | 6.5e-04 | 5.5 | 5.4 | 5.1e-08 | 0.82 | 0.09 | 0.16 | FALSE |