TWAS hub - BAIAP2L2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0750	0.0260	5.7e-06	0.018	0.026	0.047	0.025	0.040	2.7e-03	3.1e-04	1.8e-06	0.00049	1.2e-05
2	GTEx	Adipose Subcutaneous	0.1130	0.0400	1.3e-03	0.032	NA	0.032	NA	0.043	1.1e-03	NA	1.1e-03	NA	1.8e-04
3	GTEx	Esophagus Mucosa	0.3400	0.0570	0.0e+00	0.329	NA	0.357	NA	0.365	1.4e-22	NA	8.3e-25	NA	1.7e-25
4	GTEx	Nerve Tibial	0.0665	0.0312	5.9e-03	0.067	NA	0.022	NA	0.058	1.6e-05	NA	1.1e-02	NA	5.7e-05
5	GTEx	Skin Sun Exposed Lower leg	0.0930	0.0310	6.6e-05	0.092	NA	0.085	NA	0.091	4.7e-08	NA	1.6e-07	NA	5.5e-08
6	YFS	Blood	0.2848	0.0490	0.0e+00	0.032	0.103	0.119	NA	0.107	1.2e-10	7.9e-32	1.1e-36	NA	3.7e-33
7	TCGA	Brain Lower Grade Glioma	0.0536	0.0308	1.3e-03	0.011	0.028	0.026	NA	0.017	1.7e-02	3.7e-04	5.4e-04	NA	4.0e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Trunk fat percentage	7.6	30.4	81.5	-3.4	-9.0	4.9	1.8	-7.4	-1.7	-5.9
Breast Cancer	7.4	17.8	49.4	-3.1	-3.7	5.0	2.5	-7.0	1.4	-4.4
Body fat percentage	6.4	25.1	67.4	-3.1	-8.2	4.5	1.7	-6.4	-1.5	-5.6
Trunk fat mass	6.3	27.0	62.4	-3.5	-7.9	5.1	2.2	-7.2	-1.3	-5.5
Hearing difficulty/problems: Yes	5.7	8.7	21.8	-4.0	1.8	4.7	3.9	0.6	0.5	-2.1
Whole body fat mass	5.6	23.3	49.4	-3.6	-7.0	4.9	2.5	-6.5	-1.0	-5.4
Triglycerides	5.0	8.1	27.4	0.3	4.4	-2.4	-0.5	5.2	0.9	1.9
Arm fat percentage (left)	4.8	19.1	40.3	-3.5	-6.3	4.3	2.3	-5.5	-1.0	-5.0
Deep venous thrombosis (DVT) (self-reported)	4.8	6.1	12.3	-1.2	-3.0	1.9	1.2	-3.5	-2.8	-2.7
Reaction Time	4.6	8.8	16.7	3.7	2.8	-3.0	-3.1	2.2	0.1	4.1
Leg fat mass (right)	4.6	18.0	36.7	-3.2	-6.1	4.3	2.4	-5.6	-0.7	-4.8
Hearing difficulty/problems with background noise	4.5	7.3	14.6	-3.8	1.3	3.8	3.7	-0.3	-1.0	-2.4
Coronary Artery Disease (CAD)	4.4	5.2	12.1	-1.9	-1.7	3.5	2.1	-2.0	-1.5	-2.6
Arm fat percentage (right)	4.4	17.3	38.7	-3.2	-6.2	4.0	2.0	-5.4	-0.9	-4.7
Mean time to correctly identify matches	4.4	8.3	15.0	3.8	2.2	-3.0	-3.1	2.3	-0.1	3.9
Blood clot in the leg (DVT)	4.2	5.5	10.4	-1.1	-3.0	1.7	1.0	-3.2	-2.7	-2.6
Leg fat mass (left)	4.2	16.6	34.2	-3.0	-5.8	4.2	2.1	-5.5	-0.5	-4.5
Arm fat mass (right)	3.8	15.8	30.0	-3.3	-5.2	4.2	2.5	-5.5	-0.3	-4.4
Leg fat percentage (right)	3.8	13.6	37.4	-2.3	-6.1	3.4	1.6	-4.2	-1.2	-4.3
Pack years of smoking	3.7	5.4	13.0	-3.6	0.1	3.1	2.8	-1.2	0.7	-2.3
Pack years adult smoking proportion	3.6	5.6	13.5	-3.7	0.2	3.2	2.8	-1.2	0.7	-2.2
Arm fat mass (left)	3.6	14.7	27.2	-3.3	-4.9	4.0	2.5	-5.2	-0.3	-4.3
Diabetes (self-reported)	3.5	5.4	10.9	1.5	3.3	-2.5	-1.5	3.1	0.6	2.4
Impedance of arm (right)	3.5	16.4	59.4	0.2	-7.7	1.6	-1.4	-5.6	-3.0	-3.1
LDL Cholesterol	3.4	5.3	8.9	2.1	2.6	-2.8	-2.4	3.0	0.1	1.8
Smoking status: Previous	3.4	5.0	11.0	2.8	-1.5	-2.9	-3.3	0.1	-0.8	2.2
Impedance of arm (left)	3.3	15.2	57.3	-0.2	-7.6	1.7	-1.2	-5.1	-2.9	-3.2
Leg fat percentage (left)	3.3	11.9	35.1	-2.0	-5.9	3.2	1.2	-4.1	-0.9	-4.0
Medication: Gliclazide	3.0	3.4	5.4	2.0	1.1	-2.2	-2.3	2.0	-0.1	2.1
Weight	2.9	14.0	31.5	-3.0	-4.5	4.3	2.2	-5.6	0.3	-3.8
Birth weight of first child	2.9	5.2	10.6	-3.0	-2.2	3.3	1.5	-2.9	0.2	-1.4
Past tobacco smoking	2.8	5.1	11.3	-2.7	0.6	3.0	3.4	-1.0	0.7	-2.5
Breast cancer (self-reported)	2.8	3.4	11.6	0.5	1.5	-1.8	-1.7	3.4	-1.0	1.6
Diverticular disease/diverticulitis (self-reported)	2.7	3.2	5.6	-2.0	-1.8	2.0	1.8	-1.1	-1.0	-2.4
Medication: Ibuprofen	2.7	3.2	7.7	2.8	0.6	-1.9	-2.4	1.2	-0.2	1.8
Comparative height size at age 10	2.7	15.1	42.9	-2.3	-5.6	3.9	1.7	-6.6	0.2	-2.9
Alzheimer’s Disease (in father)	2.5	2.7	6.7	0.5	2.3	-2.1	-0.6	2.6	-0.3	1.3
Breastfed as a baby	2.5	3.1	6.0	2.3	1.5	-1.0	-2.1	1.6	0.5	2.5
Ever taken oral contraceptive pill	2.5	2.8	5.1	1.2	2.2	-1.4	-0.9	2.3	0.9	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.8	8.2	0.6	-2.9	1.2	0.6	-2.4	0.4	-1.8
Long-standing illness, disability or infirmity	2.4	3.7	6.1	1.1	2.5	-2.0	-2.2	1.5	1.8	2.1
Alzheimer’s Disease (including proxy)	2.3	3.3	6.4	1.0	1.2	-2.2	-2.5	1.5	0.8	2.5
Age when periods started (menarche)	2.3	5.6	9.9	2.7	1.5	-2.9	-2.7	2.0	0.4	3.2
Hip circumference	2.3	9.8	18.6	-2.3	-4.3	3.6	1.6	-4.3	-0.6	-3.2
Diabetes diagnosed by doctor	2.3	3.9	10.5	0.6	3.2	-1.9	-0.7	2.6	0.9	2.1
Impedance of whole body	2.3	11.8	49.8	1.2	-7.1	0.6	-2.2	-3.9	-2.5	-2.3
Intelligence (Savage-Jansen 2018)	2.2	6.8	21.2	2.3	4.6	-1.4	-1.7	2.8	0.5	2.8
Alzheimer’s Disease (in mother)	2.2	2.6	7.3	1.2	-0.1	-1.3	-2.7	0.5	0.7	2.6
Falls in the last year	2.2	2.9	7.7	-1.3	-1.7	2.2	0.4	-2.8	-0.4	-1.7
Respiratory disease	2.1	4.7	7.2	2.2	2.7	-2.2	-1.8	2.3	1.2	2.4
Type 2 Diabetes (T2D) (2018)	2.1	4.0	8.9	1.2	3.0	-2.1	-1.5	2.2	0.6	2.4
Leg fat-free mass (left)	2.1	11.1	21.1	-3.6	-2.1	4.3	3.2	-4.6	1.0	-3.1
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	3.8	-1.9	-1.7	1.5	1.8	-1.2	-1.1	-1.8
Leg predicted mass (left)	2.0	10.8	20.9	-3.5	-2.1	4.2	3.2	-4.6	0.9	-3.1
Number of incorrect matches in round	2.0	3.3	5.0	-2.2	-1.5	2.1	1.8	-1.6	1.2	-2.0
Happiness	2.0	2.4	6.2	-0.2	2.1	0.1	0.5	1.5	2.5	1.8
Shortness of breath walking on level ground	2.0	2.3	9.9	-0.1	-3.2	1.2	0.2	-1.1	-1.3	-1.4
Hearing aid user	2.0	2.2	7.5	-1.4	1.2	2.7	1.7	0.0	0.8	-0.9
Age started oral contraceptive pill	2.0	2.5	4.6	0.7	1.5	-2.1	-1.5	2.0	0.7	1.9
Age at First Birth	1.9	2.8	7.2	2.0	1.1	-1.6	-2.7	0.6	1.0	1.6
HbA1C	1.9	2.1	6.8	1.1	-1.0	-1.5	-2.6	0.1	-1.8	0.5
Ever had hysterectomy (womb removed)	1.9	2.1	6.5	-0.6	-1.4	1.3	0.8	-2.6	-0.4	-1.8
Friendships satisfaction	1.9	2.3	7.7	0.3	2.0	-0.3	-0.4	1.2	2.8	1.7
Body Mass Index (BMI) (2010)	1.8	2.4	4.7	-1.7	-2.2	1.6	1.4	-1.5	-0.7	-1.4
Birth weight	1.8	3.8	13.4	-1.3	-2.3	1.6	0.8	-3.7	-0.1	-1.9
BMI	1.7	10.0	14.2	-3.5	-3.4	3.4	3.0	-3.8	-0.2	-3.4
Maternal smoking around birth	1.7	2.5	5.5	2.3	-0.1	-1.9	-1.8	1.2	-1.1	1.5
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	3.9	1.2	0.3	-1.0	-2.0	2.0	1.0	1.5
Qualifications: College or University degree	1.7	5.4	10.0	1.4	2.5	-2.8	-2.7	2.0	0.9	3.2
Mouth/teeth dental problems: Loose teeth	1.7	2.0	5.1	1.3	1.0	-2.3	-0.6	2.2	0.3	1.1
Fractured/broken bones in last 5 years	1.7	2.2	5.1	-0.8	-0.8	2.3	1.2	-1.2	-1.7	-1.7
Smoking Status	1.6	3.7	7.2	2.4	-0.1	-2.3	-2.7	0.8	0.6	2.6
Medication: Metformin	1.6	2.3	9.7	0.2	3.1	-1.0	-0.1	2.0	0.4	1.1
Waist circumference	1.6	6.0	9.5	-2.5	-2.7	2.9	1.9	-2.6	-0.0	-3.1
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	6.5	2.5	0.8	-1.3	-1.9	0.6	-0.2	1.1
Family relationship satisfaction	1.6	1.9	10.4	0.1	1.2	-0.3	-0.4	0.5	3.2	1.1
Leg fat-free mass (right)	1.6	8.7	17.2	-3.2	-1.6	3.8	2.9	-4.2	1.3	-2.5
Leg predicted mass (right)	1.6	8.3	17.0	-3.0	-1.5	3.7	2.8	-4.1	1.3	-2.5
Heart disease (siblings)	1.6	1.9	5.1	-0.7	-2.3	1.3	0.4	-1.2	-1.5	-1.6
HDL Cholesterol	1.5	2.4	7.9	0.1	-2.8	0.5	-0.3	-2.6	-0.7	-1.1
Body mass index (BMI)	1.5	6.3	8.9	-2.7	-2.4	3.0	2.2	-2.9	0.5	-2.9
Ever unenthusiastic/disinterested for a whole week	1.5	1.9	4.4	-2.1	-0.6	2.1	1.7	-0.3	-0.0	-1.1
Asthma	1.5	3.0	8.9	0.9	3.0	-1.5	-1.0	1.9	1.5	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	2.0	5.1	-0.2	-1.3	0.6	1.5	0.1	-2.3	-2.1
Commuting to job workplace: Car/motor vehicle	1.5	1.7	4.3	-0.2	1.4	-0.5	-0.9	2.1	1.7	1.3
Asthma (self-reported)	1.5	3.0	10.4	0.9	3.2	-1.4	-0.8	1.9	1.4	1.4
Mother’s age at death	1.5	1.9	4.3	2.1	1.2	-1.4	-1.6	0.1	0.3	1.7
Pain type(s) experienced in last month: Hip pain	1.5	1.8	3.2	1.7	1.8	-1.1	-0.9	1.0	1.0	1.7
Diabetes (father)	1.4	1.8	6.7	0.0	1.7	0.7	0.0	0.7	2.6	1.5
Osteoarthritis (self-reported)	1.4	1.8	4.3	1.4	-1.0	-2.1	-2.0	0.9	-0.3	0.7
Tinnitus: Yes, now most or all of the time	1.4	1.6	3.1	-1.6	0.2	1.4	1.8	1.1	1.0	-1.2
Ever smoked	1.4	2.5	5.7	1.3	0.8	-1.7	-2.1	1.3	-0.1	2.4
Blood Red Count	1.3	13.0	46.9	-1.1	6.8	-1.8	1.2	5.5	2.7	0.7
Impedance of leg (left)	1.3	6.1	23.0	2.4	-4.8	-0.9	-2.6	-1.5	-2.0	-0.9
Length of working week for main job	1.3	1.4	3.8	2.0	-0.5	-1.4	-1.9	-0.2	-0.1	0.4
Peak expiratory flow (PEF)	1.3	2.9	8.1	-0.1	-2.8	1.4	-0.5	-2.8	0.6	-1.4
Wheeze or whistling in the chest in last year	1.3	2.3	5.1	0.8	2.1	-1.1	-1.0	2.3	1.2	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.6	1.1	1.1	-0.9	-1.4	1.9	0.6	1.2
Mood swings	1.3	2.4	5.4	-1.4	-0.5	2.1	1.9	-1.0	0.1	-2.3
Impedance of leg (right)	1.2	5.7	22.3	1.8	-4.7	-0.5	-1.9	-1.6	-2.4	-1.4
Qualifications: None of the above	1.2	2.7	6.1	-0.8	-2.2	1.4	1.1	-2.5	-0.6	-1.8
Neck or shoulder pain in last month	1.2	1.8	5.3	2.3	1.2	-1.2	-1.7	0.7	0.3	0.9
Number of full sisters	1.2	1.4	2.6	-1.5	-1.0	1.3	1.0	-1.6	-0.0	-1.2
Medication for cholesterol	1.2	1.8	5.2	0.8	-0.2	-2.3	-1.6	0.9	-0.7	1.7
Basal metabolic rate	1.2	6.9	13.2	-2.7	-1.3	3.4	2.7	-3.6	1.3	-2.3
Alcohol drinker status: Previous	1.2	1.3	2.8	-1.2	-0.9	1.1	1.7	-0.9	-0.9	-1.2
Heel T-Score	1.1	8.5	21.7	-4.4	-0.7	1.1	4.7	0.1	-1.1	-3.9
Had other major operations	1.1	1.4	3.0	0.7	0.7	-1.4	-1.4	0.8	1.0	1.7
Pulse wave reflection index	1.1	1.4	2.9	1.1	1.7	-0.6	-1.1	1.1	0.4	1.6
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	5.0	0.2	2.1	-0.9	-1.0	0.9	0.7	2.2
Ever had bowel cancer screening	1.1	1.3	2.6	0.9	-1.1	-1.6	-1.0	1.2	-1.0	0.9
Cholesterol lowering medication	1.1	1.6	3.7	-1.2	0.7	1.1	1.8	0.6	0.9	-1.9
Ulcerative Colitis	1.0	1.5	3.9	-1.8	1.1	0.9	0.8	-0.6	2.0	-0.4
Blood Platelet Count	1.0	11.9	24.2	-3.9	-2.1	4.1	3.7	-1.7	-2.6	-4.9
Number of treatments/medications taken	1.0	1.8	3.9	1.4	1.1	-1.1	-2.0	1.1	1.0	1.4
Frequency of depressed mood in last 2 weeks	1.0	1.3	3.2	1.8	0.9	-0.9	-0.8	1.8	-0.8	0.2
Supplements: Zinc	1.0	1.0	2.5	-1.0	0.9	1.1	1.6	0.1	1.1	-0.8
Fed-up feelings	1.0	1.9	5.9	-1.5	0.5	1.4	2.4	-0.4	1.5	-0.7
Standing height	1.0	9.8	37.0	-0.7	-4.3	2.9	0.2	-6.1	-0.3	-2.0
Health satisfaction	1.0	1.3	5.1	-0.2	1.7	0.9	-0.2	0.6	2.3	0.1
Emphysema/chronic bronchitis	1.0	1.1	3.2	0.6	0.6	-1.4	-0.4	1.2	-1.8	0.7
Migraine (self-reported)	1.0	1.3	2.8	1.7	0.2	-1.0	-0.3	1.6	-1.4	-0.6
Medication: Atorvastatin	1.0	1.3	3.3	-1.1	0.7	1.2	1.1	-0.9	1.8	-0.6
Tanning	0.9	11.3	33.1	2.4	-5.8	0.8	-1.9	-5.5	-2.1	-1.2
Townsend deprivation index at recruitment	0.9	1.3	4.4	-0.8	-2.1	0.7	0.7	-0.7	-1.2	-1.1
Neuroticism score	0.9	1.9	4.5	-1.0	0.1	2.1	2.1	-0.4	0.1	-1.9
Noisy workplace	0.9	1.1	2.5	-1.6	-0.6	1.1	0.6	0.6	-0.8	-1.4
Prospective memory result	0.9	1.1	4.0	0.7	-2.0	-0.9	-0.5	-0.8	-1.4	-0.2
Tense / ‘highly strung’	0.9	1.5	5.2	-1.1	-0.2	1.1	1.5	-0.1	-0.8	-2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	5.0	-0.5	-0.6	0.1	1.3	0.2	-2.2	-1.6
Loud music exposure frequency	0.9	1.0	2.7	-1.6	0.2	0.8	1.2	1.1	-0.2	-1.1
Medication: Paracetamol	0.9	1.4	2.5	1.5	1.3	-1.6	-0.8	1.5	0.3	0.6
Whole body fat-free mass	0.9	5.0	8.6	-2.4	-0.1	2.9	2.8	-2.8	1.6	-1.6
Handedness (chirality/laterality): Left-handed	0.9	1.0	3.2	-1.3	-0.1	1.0	1.8	-0.3	0.5	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	4.8	-0.5	-2.2	-0.5	0.0	-0.9	-0.7	-1.0
Whole body water mass	0.9	5.0	8.6	-2.5	-0.0	2.9	2.8	-2.8	1.5	-1.6
Major Depression (MDD)	0.8	1.0	3.6	-0.1	-1.9	1.0	0.6	-0.8	-0.7	-0.8
Lupus	0.8	1.3	3.9	0.6	-0.2	-2.0	-0.8	1.1	1.4	0.8
Average weekly fortified wine intake	0.8	1.0	2.1	1.4	-0.2	-0.9	-1.2	-0.8	-1.4	0.1
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.8	0.7	1.2	-1.3	-0.9	0.0	0.2	1.1
High blood pressure (mother)	0.8	1.2	5.9	0.3	0.3	-1.1	-0.3	0.4	2.4	0.9
Glaucoma (self-reported)	0.8	1.0	3.5	-0.9	-1.9	0.9	0.9	0.2	-0.2	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	3.2	0.3	-0.6	-1.0	-0.5	-1.0	1.8	0.2
Medication: Omeprazole	0.8	0.9	3.4	0.7	-1.8	-0.2	-0.3	-1.4	0.4	-0.1
Mineral and other dietary supplements	0.8	1.0	5.4	-0.5	-2.3	-0.1	0.0	-0.2	-0.5	-1.1
Miserableness	0.8	1.4	4.5	-1.0	0.2	1.5	2.1	0.1	0.7	-1.3
Financial situation satisfaction	0.8	0.9	1.9	0.8	0.4	-1.4	-0.7	1.2	1.0	1.0
Medication: Paracetamol	0.8	1.2	2.1	1.4	1.0	-1.4	-1.1	1.5	-0.2	0.5
Schizophrenia vs Biploar Disorder	0.7	0.9	2.1	-1.5	1.1	0.6	1.0	1.2	-0.4	-0.3
Neuroticism (2016)	0.7	1.0	3.5	1.2	-0.8	0.1	-1.0	0.4	-1.9	0.1
Height	0.7	14.0	58.7	-0.3	-5.1	3.5	-0.6	-7.7	0.2	-1.1
Lung FEV1/FVC ratio	0.7	3.3	13.1	-0.5	-3.6	0.9	0.2	-2.7	0.7	-1.0
Other serious medical condition/disability diagnosed by doctor	0.7	0.8	1.6	1.2	1.2	-0.6	-1.3	-0.1	0.9	0.5
Medication for hormone replacement therapy	0.7	0.8	3.5	0.4	0.7	0.9	0.1	-1.9	0.2	-0.8
Taking other prescription medications	0.7	1.1	1.6	1.1	1.3	-0.8	-1.3	1.0	0.7	1.1
Serious illness, injury or assault to yourself	0.7	0.8	1.9	-1.1	0.6	1.1	1.4	0.0	0.4	-0.8
Sitting height	0.7	5.3	23.5	0.3	-3.0	1.8	-0.4	-4.9	0.5	-0.8
Illnesses of mother	0.7	0.9	1.7	-0.3	-1.0	1.3	0.4	-0.9	-1.3	-1.0
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.5	-0.9	0.5	0.1	1.6	0.1	-1.4	-0.5
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.0	0.7	-0.4	-1.4	-0.8	1.0	0.9	1.0
Arm fat-free mass (right)	0.7	3.5	6.3	-2.3	0.3	2.5	2.5	-1.7	1.5	-1.3
Medication: Aspirin	0.7	0.9	3.9	-0.3	2.0	0.3	0.3	1.3	-0.6	-0.2
Eye problems/disorders: Glaucoma	0.7	0.8	3.1	-0.3	-1.8	0.0	0.4	0.1	-0.7	-1.3
Depressed Affect (Nagel 2018)	0.6	1.3	2.9	-0.6	-0.4	1.4	1.7	-1.5	-0.0	-1.4
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.0	0.8	1.7	-0.2	-0.3	1.6	0.8	1.7
Prostate Cancer	0.6	0.8	1.7	0.9	0.2	-0.3	-1.3	1.3	-1.1	0.1
Blood Eosinophil Count	0.6	4.7	8.8	0.3	2.6	-3.0	-1.6	2.5	0.6	2.9
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	3.8	-1.9	0.7	0.2	1.4	1.1	-0.9	-1.0
Mouth/teeth dental problems	0.6	0.9	1.5	-0.8	0.1	1.2	1.0	-1.2	-1.0	-0.8
Fluid intelligence score	0.6	1.3	2.7	1.3	1.2	-0.6	-1.4	0.7	0.7	1.6
Hair/balding pattern: Pattern 3	0.6	0.9	4.1	0.6	-2.0	-0.0	-1.0	-0.3	-0.8	0.4
Number of live births	0.6	0.8	3.4	-0.0	-1.0	0.4	0.3	-0.6	-1.9	-1.0
Qualifications: A levels/AS levels or equivalent	0.6	1.2	4.3	-0.2	1.5	-0.7	-1.1	0.5	0.5	2.1
Depression (self-reported)	0.6	0.8	2.2	0.3	1.5	-0.3	0.4	1.2	0.7	0.9
Lung cancer (father)	0.6	0.7	1.7	1.2	0.4	-0.6	-0.9	0.1	-0.3	1.3
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.9	-1.3	-0.3	1.0	1.4	-0.6	-0.7	-1.1
Number of children fathered	0.6	0.7	2.9	0.2	-1.7	-0.1	0.2	-0.6	-1.1	-0.6
Arm predicted mass (right)	0.6	3.2	6.2	-2.1	0.2	2.5	2.3	-1.7	1.5	-1.2
Chest pain or discomfort	0.6	0.8	2.0	1.0	0.6	-1.3	0.0	1.4	-0.8	-0.3
Supplements: Vitamin C	0.6	0.7	2.2	-0.8	1.1	1.5	0.6	-0.1	0.2	-0.3
Loneliness, isolation	0.6	0.8	1.4	-0.3	-1.1	1.2	1.1	-0.5	-0.6	-1.0
Osteoporosis (self-reported)	0.6	0.8	1.6	1.2	0.6	-0.8	-1.3	-0.9	-0.8	0.3
Alcohol drinker status: Never	0.6	0.7	2.2	1.0	-0.8	0.2	-1.1	-1.5	-0.2	0.1
Risk taking	0.6	0.8	3.9	-0.3	1.2	-0.4	0.1	2.0	0.0	-0.2
Pain experienced in last month	0.6	1.0	2.1	-1.1	-1.4	0.7	0.8	-1.3	-0.8	-0.6
Basal cell carcinoma (self-reported)	0.6	0.7	2.1	0.3	1.1	-0.1	0.5	1.4	0.7	-0.7
Worry (Nagel 2018)	0.5	1.1	2.5	-0.2	-0.2	1.1	1.2	-1.4	-0.8	-1.6
Mean Putamen Volume	0.5	0.5	1.3	0.4	-0.2	-0.5	-1.1	-0.8	-1.1	0.2
Fasting Glucose	0.5	0.5	1.7	0.6	-0.5	-1.3	-0.4	0.9	-0.7	-0.2
Chronotype (morning person)	0.5	1.0	3.3	-0.3	-1.8	0.8	1.0	-1.3	-0.3	-0.8
Sensitivity / hurt feelings	0.5	0.8	2.4	-0.3	-0.1	1.3	1.5	-0.6	0.3	-1.1
Hand grip strength (right)	0.5	1.5	3.9	-1.3	0.3	0.8	2.0	-0.4	0.5	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.7	-1.6	0.7	-0.5	1.3	1.4	0.1	-0.8
Financial difficulties in last 2 years	0.5	0.7	1.8	0.8	-0.7	-0.4	-0.8	-1.3	-1.0	-0.6
Pain all over the body in last month	0.5	0.5	1.7	-0.3	-0.8	0.5	0.3	-0.4	-0.9	-1.3
Medication: Ramipril	0.5	0.7	1.7	-0.8	-0.1	1.3	1.0	-1.1	0.2	-0.3
Trunk fat-free mass	0.5	3.1	5.5	-1.7	1.1	2.1	2.3	-1.8	1.9	-0.6
Worrier / anxious feelings	0.5	0.9	2.4	-0.2	0.1	1.5	1.2	-0.7	0.3	-1.4
Pulse wave Arterial Stiffness index	0.5	0.6	1.8	-0.3	-0.8	1.1	-0.0	-1.3	0.6	0.2
Trunk predicted mass	0.5	3.1	5.9	-1.7	1.1	2.2	2.4	-1.8	1.9	-0.6
Hair/balding pattern: Pattern 4	0.5	1.1	3.7	1.6	-0.8	-0.4	-1.9	-0.4	0.3	0.7
Exposure to tobacco smoke outside home	0.5	0.6	1.8	-0.6	-1.4	0.4	0.3	-0.5	-1.2	-0.5
Number of full brothers	0.5	0.6	2.0	0.5	-0.7	-0.5	0.8	0.7	-1.4	0.0
Medication: Seretide 50 evohaler	0.5	0.6	1.8	-0.4	0.7	0.7	1.3	-0.7	-0.7	-0.1
Heart disease (mother)	0.5	0.6	1.2	0.5	0.9	-1.0	-0.5	0.6	1.1	-0.2
Had major operations	0.5	0.6	1.7	-0.8	0.4	0.3	0.2	-0.7	1.3	1.0
Medication: Aspirin	0.5	0.7	2.3	-0.4	1.5	0.3	0.4	1.0	-0.8	-0.6
Back pain experienced in last month	0.5	0.7	1.6	1.3	1.1	-0.6	-0.8	0.4	0.7	0.2
Smoking status: Current	0.5	0.8	3.0	-0.5	0.9	0.7	0.3	0.2	1.7	0.9
Wears glasses or contact lenses	0.5	0.6	1.3	-0.7	-0.6	1.1	0.7	-0.9	-0.3	-0.9
Medication: Lisinopril	0.5	0.6	1.1	0.3	1.1	1.0	0.5	1.0	-0.6	-0.8
Arm fat-free mass (left)	0.5	2.7	4.6	-1.6	0.2	2.1	1.9	-2.0	1.7	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	2.7	-0.0	-1.6	0.4	0.2	-1.2	-0.3	-0.6
Arm predicted mass (left)	0.5	2.6	4.3	-1.5	0.3	2.1	1.8	-2.0	1.8	-1.0
Irritable Bowel Disease (IBD)	0.4	0.9	2.3	-0.7	-1.5	0.4	0.5	-0.3	0.7	-1.5
Ulcerative Colitis (UC)	0.4	0.8	2.2	-0.9	-1.0	0.0	0.4	-0.4	1.5	-1.1
Schizophrenia (2014)	0.4	0.9	2.6	-1.3	1.6	0.2	0.5	1.1	0.9	0.2
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.9	0.6	0.9	-0.9	-0.8	0.3	0.5	0.3
Allergy or Eczema	0.4	1.1	2.9	0.8	1.6	-0.6	-1.7	0.3	0.4	0.9
Average weekly spirits intake	0.4	0.6	1.4	-0.0	-1.2	-0.2	-1.1	-0.6	-0.9	0.1
Systolic blood pressure, automated reading	0.4	1.2	4.0	0.7	-2.0	0.2	-0.5	-1.2	-0.5	-1.4
Medication: Co-codamol	0.4	0.4	0.9	-0.9	-0.8	1.0	0.3	-0.2	0.6	-0.2
Diabetes (mother)	0.4	0.6	1.1	-1.0	0.6	-0.4	0.9	0.5	-0.8	-0.7
Current tobacco smoking	0.4	0.7	3.2	0.1	0.7	0.5	-0.2	-0.4	1.8	1.0
Qualifications: CSEs or equivalent	0.4	0.5	1.2	0.1	1.1	0.4	0.4	1.1	0.8	0.1
Stomach or abdominal pain in last month	0.4	0.5	1.3	0.8	-0.8	-0.3	-0.6	-0.4	-1.2	-0.3
Chronic bronchitis/emphysema (father)	0.4	0.4	1.2	0.3	1.1	-0.9	0.2	0.0	-0.8	-0.2
Had menopause	0.4	0.5	1.9	0.3	-0.0	-0.9	-1.4	-0.5	-0.3	0.8
Time employed in main current job	0.4	0.5	2.4	-0.0	0.7	-0.3	-0.3	1.6	-0.0	0.4
Medication: Lansoprazole	0.4	0.5	1.5	-0.0	-1.2	-0.3	0.5	-1.1	0.5	-0.0
Exposure to tobacco smoke at home	0.4	0.4	1.7	0.3	-0.1	-0.6	0.7	0.7	-1.3	0.3
Gout (self-reported)	0.4	0.5	1.4	0.7	0.3	-1.2	-0.7	0.9	-0.1	0.6
Medication: Ventolin 100micrograms inhaler	0.4	0.6	2.6	-0.5	1.6	-0.0	0.2	0.9	0.1	0.3
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.8	0.7	0.3	-0.3	-1.3	0.3	-0.4	0.8
High blood pressure (siblings)	0.4	0.5	1.4	-1.0	0.9	-0.2	0.3	1.2	-0.0	-0.4
Worry too long after embarrassment	0.4	0.7	2.7	0.1	-0.7	0.6	0.3	-1.6	0.6	-0.8
Eye problems/disorders: None of the above	0.4	0.5	1.4	-1.2	0.4	0.2	1.0	0.3	0.7	-0.2
Medication for pain relief, constipation, heartburn	0.4	0.7	1.7	-1.3	-0.9	0.9	0.8	-0.8	-0.2	-0.4
Suffer from ‘nerves’	0.4	0.6	1.2	0.1	0.3	1.1	0.8	-0.5	0.9	-1.1
Overall health rating	0.4	0.9	2.9	-0.3	0.9	0.6	-0.2	1.3	1.7	0.1
Knee pain experienced in last month	0.4	0.6	2.2	1.0	-0.4	-0.3	-1.5	-0.1	-0.6	0.8
Illnesses of siblings: Diabetes	0.4	0.4	2.2	0.2	1.5	-0.2	0.3	0.8	-0.2	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.4	-0.1	-1.8	0.5	0.2	-1.2	0.8	-0.5
Commuting to job workplace: Walk	0.4	0.4	1.0	-0.1	-0.6	0.1	0.5	-0.7	-1.0	-0.8
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.9	-0.3	1.7	0.3	0.3	-0.2	0.2	0.6
Medication: Bendroflumethiazide	0.4	0.5	1.8	0.9	-1.4	-0.1	-0.5	-0.1	-0.8	-0.5
Number of operations (self-reported)	0.4	0.7	2.9	-0.5	-0.0	0.2	-0.3	-1.0	1.7	0.5
Average weekly beer plus cider intake	0.4	0.5	1.5	0.1	0.6	-1.2	-0.6	0.6	0.4	1.0
Irritability	0.4	0.7	1.4	-1.1	0.7	1.2	1.2	0.6	-0.0	0.0
Ever depressed for a whole week	0.4	0.5	1.5	-0.8	0.7	-0.0	-0.3	1.2	-1.0	-0.1
Bipolar Disorder (2018)	0.3	0.5	1.0	-0.6	1.0	0.4	0.8	0.4	1.0	-0.8
Crohns Disease (2017)	0.3	0.6	3.0	0.5	-1.7	-0.3	-0.4	0.2	-0.5	-0.8
Primary Biliary Cirrhosis	0.3	0.5	2.5	0.2	-1.6	0.3	0.0	-0.0	-0.7	-0.5
Rheumatoid Arthritis	0.3	0.4	1.1	-0.6	-0.6	0.8	0.5	-0.0	-1.0	-0.5
Lung FVC	0.3	1.4	3.2	1.8	-0.0	-1.5	-1.7	0.4	0.0	1.0
Neuroticism	0.3	0.8	2.7	-0.5	0.2	1.0	1.7	-0.6	-0.1	-1.1
Hand grip strength (left)	0.3	0.8	2.0	-1.4	0.4	0.5	1.2	-0.8	-0.1	-1.2
Relative age voice broke	0.3	0.5	1.3	-0.4	1.0	0.0	-1.0	0.5	-1.1	0.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.8	0.9	0.6	-0.7	-0.7	-0.1	0.6	0.5
Supplements: Glucosamine	0.3	0.4	1.1	0.5	0.1	1.0	-0.0	-1.0	-0.5	-0.1
Medication: Atenolol	0.3	0.4	2.1	0.2	-1.4	-0.2	-0.7	0.0	-0.1	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	-0.3	-0.4	0.1	0.8	0.6	-1.2	-1.0
Medication: Simvastatin	0.3	0.5	1.7	0.5	-0.3	-0.3	-0.0	1.3	-0.8	-0.7
Pulse rate	0.3	0.6	1.4	-0.9	-0.8	0.8	1.2	0.1	-0.1	-0.8
Mouth/teeth dental problems: Dentures	0.3	0.4	1.5	0.7	0.0	-0.6	-1.2	0.4	-0.1	0.7
Medication: Amlodipine	0.3	0.4	0.9	0.3	-0.0	-0.9	-0.5	0.8	0.1	1.0
Comparative body size at age 10	0.3	0.7	1.6	-0.9	0.1	1.1	0.3	-1.3	1.0	-0.6
Age at first live birth	0.3	0.6	1.3	0.0	0.2	-0.2	-1.0	0.6	1.2	1.1
Pulse wave peak to peak time	0.3	0.3	1.0	0.3	0.5	-0.9	-0.0	1.0	-0.4	-0.2
Medication: Blood pressure	0.3	0.5	1.0	0.9	0.0	-0.7	-0.7	0.8	0.3	1.0
Medication: Allopurinol	0.3	0.4	1.2	-0.3	0.8	0.1	0.2	1.1	1.1	0.1
Leg pain on walking	0.3	0.3	1.2	0.5	-0.1	0.2	-0.6	0.6	-1.1	-0.4
Illnesses of father: Heart disease	0.3	0.3	1.4	0.4	-0.3	0.5	-1.2	-0.3	0.5	0.5
Average weekly red wine intake	0.3	0.4	1.1	-0.5	-1.0	-0.1	0.2	-0.9	-0.8	-0.0
Qualifications: nursing, teaching	0.3	0.5	1.5	0.4	-1.2	-0.7	-1.0	-0.2	-0.6	0.2
Commuting to job workplace: Public transport	0.3	0.3	1.0	-0.2	0.7	0.1	1.0	-0.0	-0.7	0.3
Medication: Blood pressure	0.3	0.6	2.0	-0.0	0.4	1.4	0.5	-0.2	1.1	-0.6
Commuting to job workplace: Cycle	0.3	0.4	2.2	-0.0	0.1	-0.1	0.1	-0.9	1.5	0.0
Depression (Nagel 2018)	0.2	0.2	0.6	0.7	-0.7	-0.2	-0.7	0.1	-0.2	-0.4
Waist Hip Ratio (WHR)	0.2	1.1	3.6	-0.4	1.9	-0.2	0.7	1.8	0.1	-0.3
Systolic Blood Pressure	0.2	0.8	2.9	0.1	-0.3	0.7	1.2	0.4	-0.7	-1.7
Hypothyroidism (self reported)	0.2	0.5	1.7	-0.7	0.1	0.8	-0.7	-1.3	-0.2	0.2
Relative age of first facial hair	0.2	0.4	0.8	-0.4	0.5	0.1	-0.9	-0.7	-0.9	0.6
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	0.5	0.5	-0.3	-0.4	-0.2	0.7	-0.3
Angina	0.2	0.2	0.9	0.5	0.1	-0.1	-0.4	-0.4	1.0	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.8	-0.8	-0.2	0.9	0.1	-0.4	0.2	-0.8
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.1	-0.7	1.0	0.4	-0.0	-0.5	-0.3	-0.6
Multivitamins +/- minerals	0.2	0.3	0.9	1.0	0.5	-0.5	-0.4	-0.4	0.4	0.4
Medication: Levothyroxine sodium	0.2	0.4	1.6	-0.1	0.1	-0.0	-0.7	-0.1	-1.3	0.6
Nervous feelings	0.2	0.4	1.1	-0.2	-0.5	0.5	0.6	-0.8	-0.6	-1.1
Hair/balding pattern: Pattern 2	0.2	0.2	0.7	-0.8	0.2	-0.1	0.4	0.7	-0.2	-0.3
Heart attack	0.2	0.3	0.9	0.3	-0.3	0.3	0.7	-0.9	0.1	-0.4
Allergy	0.2	0.5	1.3	1.0	-1.1	-0.7	-0.1	0.3	0.6	0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.8	0.8	0.5	-0.0	-0.9	0.2	0.5	-0.2
Father’s age at death	0.2	0.2	0.5	0.3	0.7	-0.7	-0.5	-0.3	-0.2	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.1	-1.0	0.1	0.1	0.2	0.4	0.6	-0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.3	0.6	-1.1	0.4	-1.0	-1.1	0.5	-0.1
Medication: Cholesterol lowering	0.2	0.3	0.7	0.8	0.2	-0.5	-0.8	0.6	0.5	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.0	0.3	-1.4	0.5	-0.0	-1.2	-0.1	-0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.3	-0.1	0.3	-0.2	-1.1	-0.0	-1.0	0.7
Age at last live birth	0.2	0.3	0.9	-0.7	0.9	0.3	0.2	0.8	0.2	0.4
Hypertension (Self-reported)	0.2	0.5	1.9	1.0	-1.4	-0.1	-0.6	-0.1	0.4	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	1.5	-0.1	-1.2	-0.1	-0.0	-0.2	-0.3	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.3	-0.2	0.0	-0.1	0.6	1.1	-0.2	-0.8
Illnesses of father: None of the above (group 1)	0.2	0.2	0.5	-0.4	-0.7	0.3	0.3	-0.7	0.3	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.8	-0.1	-1.4	0.2	-0.4	0.1	-0.5	-0.9
Number of self-reported non-cancer illnesses	0.2	0.3	0.8	0.9	0.1	-0.5	-0.7	0.7	0.5	-0.0
Average weekly champagne plus white wine intake	0.2	0.3	0.9	0.9	-0.0	-0.4	-0.9	0.4	-0.2	0.2
Guilty feelings	0.2	0.2	1.0	-0.3	0.0	0.1	1.0	-0.0	-0.7	-0.2
High cholesterol (Self-reported)	0.2	0.3	0.7	-0.3	0.3	0.3	0.7	0.8	0.4	-0.7
Illnesses of father: High blood pressure	0.2	0.2	1.0	0.4	-0.4	-0.1	0.2	-0.1	0.1	-1.0
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.7	0.2	-0.3	0.7	0.8	-0.1	-0.5	-0.5
Diastolic blood pressure, automated reading	0.2	0.5	2.2	1.5	0.4	-0.4	-0.9	0.1	-0.1	-0.3
Unable to work because of sickness or disability	0.2	0.3	0.8	-0.9	-0.2	0.8	0.6	-0.3	0.1	-0.4
Myopia	0.2	0.2	0.7	0.1	0.8	0.6	0.2	0.2	-0.5	-0.4
Supplements: Calcium	0.2	0.2	0.4	-0.3	0.2	-0.3	-0.6	-0.2	0.6	0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.9	0.5	-0.4	-0.0	0.4	-0.9	-0.0	-0.4
Bipolar Disorder or Schizophrenia	0.1	0.3	0.9	-1.0	0.5	0.3	0.4	0.6	0.4	-0.3
Neuroticism (Nagel 2018)	0.1	0.3	0.7	0.4	-0.1	0.5	0.7	-0.9	-0.3	-0.7
Schizophrenia (2018)	0.1	0.2	0.7	-0.8	-0.2	0.1	-0.2	0.5	-0.2	0.2
Ovarian Cancer	0.1	0.2	0.9	-0.0	-0.1	0.4	-0.3	0.0	1.0	-0.0
Crohns Disease (2012)	0.1	0.2	0.6	0.0	0.4	0.6	0.4	0.3	-0.2	-0.8
Blood White Count	0.1	0.9	2.7	-0.8	1.4	0.4	0.6	1.6	-0.1	-0.3
Cardiovascular Disease	0.1	0.2	0.6	0.4	0.4	-0.2	0.5	0.8	0.2	-0.3
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.4	0.0	0.6	-0.1	-0.2	0.5	0.4	0.6
Vitamin and mineral supplements	0.1	0.1	0.3	-0.5	-0.4	0.0	0.0	0.4	-0.1	0.3
Severe depression (siblings)	0.1	0.2	0.5	-0.1	-0.3	0.5	-0.2	-0.3	0.7	-0.4
High blood pressure	0.1	0.3	1.0	0.5	-1.0	0.4	-0.0	-0.2	0.5	-0.5
Alcohol usually taken with meals	0.1	0.2	0.9	-0.5	0.1	1.0	0.0	-0.2	0.1	-0.5
Forced vital capacity (FVC)	0.1	0.5	1.5	0.6	-0.5	0.0	-1.2	-0.9	0.9	0.3
Illnesses of siblings	0.1	0.2	0.5	0.7	-0.1	-0.3	-0.1	0.2	0.2	0.7
Alcohol intake versus 10 years previously	0.1	0.2	0.7	-0.2	0.7	-0.4	0.2	-0.0	0.8	-0.4
Headache pain in last month	0.1	0.3	1.0	0.5	1.0	-0.4	-0.1	0.6	0.2	0.0
Forced vital capacity (FVC), Best measure	0.1	0.4	1.5	0.2	-0.9	0.4	-0.0	-1.2	0.0	-0.6
Angina (self-reported)	0.1	0.1	0.3	0.3	-0.5	0.1	-0.1	-0.6	0.3	-0.3
Pulse rate, automated reading	0.1	0.4	0.9	-0.6	0.3	-0.1	1.0	0.7	-0.8	-0.7
Alcohol intake frequency.	0.1	0.2	0.8	0.2	0.8	-0.3	0.1	0.9	0.3	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.4	-0.3	0.4	0.1	0.4	0.5	0.5	-0.6
Eye problems/disorders: Cataract	0.1	0.1	0.5	0.1	0.1	0.5	-0.5	-0.7	-0.1	-0.1
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.7	-0.3	0.8	-0.6	-0.1	0.1	-0.6	0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.2	4.4	1.3	-0.9	-0.8	-2.1	-0.2	0.1	0.8

Hub : Genes

BAIAP2L2

Models

Trait associations