TWAS hub - MAFF

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.085	0.0390	8.2e-03	0.079	NA	0.058	NA	0.061	1.7e-06	NA	3.5e-05	NA	2.2e-05
2	GTEx	Nerve Tibial	0.143	0.0486	6.7e-05	0.065	NA	0.048	NA	0.053	2.3e-05	NA	2.5e-04	NA	1.2e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Breast Cancer	17.7	42.6	46.1	-6.8	-6.2
Triglycerides	14.6	23.9	25.8	4.7	5.1
Trunk fat percentage	14.6	58.3	88.8	-5.3	-9.4
Trunk fat mass	11.9	51.2	72.5	-5.5	-8.5
Body fat percentage	11.7	46.1	70.9	-4.6	-8.4
Whole body fat mass	10.2	42.4	58.4	-5.1	-7.6
Diabetes (self-reported)	8.1	12.6	15.0	3.2	3.9
Impedance of arm (right)	8.1	37.6	67.7	-2.7	-8.2
Leg fat mass (right)	8.1	31.5	42.6	-4.5	-6.5
Arm fat percentage (right)	7.8	30.9	42.8	-4.4	-6.5
Arm fat percentage (left)	7.8	31.2	44.4	-4.2	-6.7
Leg fat mass (left)	7.5	29.2	38.9	-4.4	-6.2
Diabetes diagnosed by doctor	7.1	11.7	15.5	2.8	3.9
Impedance of arm (left)	7.0	32.2	60.6	-2.0	-7.8
Arm fat mass (right)	7.0	28.7	34.3	-4.8	-5.9
Birth weight	6.9	15.0	16.3	-3.7	-4.0
Comparative height size at age 10	6.7	37.0	44.5	-5.4	-6.7
Arm fat mass (left)	6.3	25.9	31.3	-4.5	-5.6
Leg fat percentage (right)	6.0	21.6	34.7	-2.9	-5.9
Breast cancer (self-reported)	6.0	7.1	10.0	3.2	2.1
Weight	5.9	28.9	32.5	-5.0	-5.7
Alzheimer’s Disease (in father)	5.8	6.3	6.6	2.5	2.6
Medication: Metformin	5.6	7.9	11.7	2.0	3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	5.5	6.5	8.8	-2.0	-3.0
Leg fat percentage (left)	5.2	19.0	30.3	-2.8	-5.5
Birth weight of first child	5.1	9.2	10.0	-3.2	-2.9
Falls in the last year	4.8	6.5	7.8	-2.3	-2.8
Deep venous thrombosis (DVT) (self-reported)	4.6	5.9	7.9	-2.0	-2.8
Impedance of whole body	4.6	23.5	46.3	-0.9	-6.8
LDL Cholesterol	4.5	7.1	7.8	2.5	2.8
Hip circumference	4.4	18.8	24.9	-3.6	-5.0
HDL Cholesterol	4.3	7.1	9.1	-2.3	-3.0
Peak expiratory flow (PEF)	4.3	9.9	14.3	-2.3	-3.8
Maternal smoking around birth	4.2	6.0	8.9	3.0	1.8
Blood clot in the leg (DVT)	3.9	5.0	7.2	-1.7	-2.7
Body Mass Index (BMI) (2010)	3.8	5.2	6.5	-2.0	-2.5
Type 2 Diabetes (T2D) (2018)	3.7	7.0	9.4	2.2	3.1
Leg fat-free mass (left)	3.6	19.1	24.4	-4.9	-3.7
Leg predicted mass (left)	3.6	19.1	24.1	-4.9	-3.7
Blood Red Count	3.3	31.9	49.8	3.7	7.1
Number of full sisters	3.2	3.9	3.9	-2.0	-2.0
Standing height	3.1	30.3	39.3	-4.6	-6.3
Height	3.0	58.4	72.9	-6.6	-8.5
Medication: Aspirin	3.0	3.9	5.8	1.4	2.4
Prostate Cancer	2.9	4.1	6.7	2.6	1.2
BMI	2.9	16.8	17.4	-4.2	-4.0
Ever had hysterectomy (womb removed)	2.9	3.2	3.3	-1.8	-1.8
Diabetes (mother)	2.9	3.7	4.9	1.6	2.2
Sitting height	2.9	20.9	24.1	-4.2	-4.9
Medication: Paracetamol	2.9	4.8	5.6	2.0	2.4
Leg fat-free mass (right)	2.9	15.3	21.3	-4.6	-3.0
Tanning	2.8	33.7	49.8	-4.2	-7.1
Leg predicted mass (right)	2.8	15.2	21.2	-4.6	-3.0
Asthma (self-reported)	2.7	5.3	9.0	1.3	3.0
Reaction Time	2.6	4.9	5.5	2.1	2.3
HbA1C	2.6	2.9	5.7	2.4	-0.2
Asthma	2.6	5.2	8.4	1.4	2.9
Mean time to correctly identify matches	2.6	4.9	5.4	2.3	2.1
Illnesses of mother	2.5	3.1	3.7	-1.6	-1.9
Mouth/teeth dental problems: Loose teeth	2.5	2.9	3.9	1.4	2.0
Medication: Simvastatin	2.4	3.6	5.7	2.4	1.2
Medication: Lansoprazole	2.4	2.7	3.2	-1.8	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.8	4.2	-1.2	-2.1
Coronary Artery Disease (CAD)	2.3	2.7	3.3	-1.4	-1.8
Diverticular disease/diverticulitis (self-reported)	2.3	2.8	4.8	-0.9	-2.2
Had other major operations	2.3	2.8	3.8	1.4	1.9
Medication: Gliclazide	2.3	2.6	3.7	1.9	1.3
Lung FEV1/FVC ratio	2.2	11.1	15.4	-2.6	-3.9
Shortness of breath walking on level ground	2.2	2.6	4.9	-0.6	-2.2
Medication: Aspirin	2.2	2.9	3.8	1.4	2.0
Basal metabolic rate	2.2	12.2	17.5	-4.2	-2.6
Basal cell carcinoma (self-reported)	2.2	2.6	3.6	1.9	1.3
Heel bone mineral density (BMD) T-score, automated (right)	2.1	4.7	6.2	1.8	2.5
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	3.6	-1.3	-1.9
Respiratory disease	2.0	4.5	5.5	1.9	2.4
Body mass index (BMI)	2.0	8.7	9.3	-3.1	-2.8
Pulse wave reflection index	2.0	2.5	3.3	1.3	1.8
Cholesterol lowering medication	2.0	3.0	4.0	1.4	2.0
Medication: Omeprazole	1.9	2.3	2.7	-1.4	-1.7
Diabetes (father)	1.8	2.3	4.0	0.8	2.0
Age when periods started (menarche)	1.8	4.3	4.7	2.0	2.2
Chronic bronchitis/emphysema (father)	1.8	2.2	3.2	1.1	1.8
Medication: Lisinopril	1.8	2.3	3.0	1.3	1.7
Intelligence (Savage-Jansen 2018)	1.7	5.1	7.1	1.8	2.7
Supplements: Zinc	1.7	1.8	3.5	-1.9	-0.5
Impedance of leg (right)	1.7	8.3	16.0	0.8	-4.0
Medication for hormone replacement therapy	1.6	1.8	3.4	-1.8	-0.5
High blood pressure (mother)	1.6	2.2	2.4	1.4	1.5
Qualifications: None of the above	1.6	3.5	3.9	-1.7	-2.0
Comparative body size at age 10	1.6	4.4	7.6	-2.8	-1.1
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	2.3	-1.2	-1.5
Impedance of leg (left)	1.5	7.4	13.8	1.0	-3.7
Waist circumference	1.5	5.3	7.0	-1.9	-2.6
Breastfed as a baby	1.5	1.8	2.4	1.1	1.5
Long-standing illness, disability or infirmity	1.5	2.3	4.1	0.7	2.0
Age started oral contraceptive pill	1.5	1.8	1.9	1.4	1.3
Pain experienced in last month	1.5	2.4	3.5	-1.1	-1.9
Verbal and Numeric Reasoning (VNR)	1.4	3.3	3.8	1.7	1.9
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	2.6	1.6	0.8
Wheeze or whistling in the chest in last year	1.4	2.5	4.2	0.9	2.0
Medication for pain relief, constipation, heartburn	1.4	2.5	3.5	-1.2	-1.9
Migraine (self-reported)	1.4	1.8	3.4	1.8	0.4
Whole body fat-free mass	1.4	8.2	14.2	-3.8	-1.4
Illnesses of father: None of the above (group 1)	1.4	1.8	2.1	-1.4	-1.2
Whole body water mass	1.4	7.8	13.8	-3.7	-1.4
Ever taken oral contraceptive pill	1.4	1.6	1.8	1.2	1.3
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	1.7	1.1	1.3
Hair/balding pattern: Pattern 2	1.3	1.6	2.2	1.5	1.0
Commuting to job workplace: Car/motor vehicle	1.3	1.5	1.9	1.0	1.4
High cholesterol (Self-reported)	1.3	2.3	2.6	1.4	1.6
Fractured/broken bones in last 5 years	1.3	1.7	2.5	-0.9	-1.6
Average weekly fortified wine intake	1.2	1.4	1.5	-1.1	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	3.2	1.5	1.8
Past tobacco smoking	1.2	2.2	4.0	-2.0	-0.6
Forced expiratory volume in 1-second (FEV1)	1.2	3.9	5.6	-1.5	-2.4
Medication: Allopurinol	1.2	1.6	2.1	1.1	1.4
Chest pain or discomfort	1.2	1.7	2.1	1.2	1.4
Illnesses of siblings: Diabetes	1.2	1.5	2.3	0.8	1.5
Heart disease (siblings)	1.2	1.5	3.0	0.0	-1.7
Waist Hip Ratio (WHR)	1.1	4.9	5.9	2.0	2.4
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	1.6	1.1	1.3
Qualifications: nursing, teaching	1.1	1.8	2.9	-0.8	-1.7
Supplements: Fish oil (including cod liver oil)	1.1	1.5	2.9	-1.7	0.1
Risk taking	1.1	1.6	1.6	1.2	1.3
Alzheimer’s Disease (including proxy)	1.0	1.5	2.2	0.9	1.5
Number of incorrect matches in round	1.0	1.6	1.8	-1.4	-1.2
Mouth/teeth dental problems	1.0	1.5	1.6	-1.2	-1.3
Noisy workplace	1.0	1.2	2.4	1.6	-0.1
Depression (self-reported)	1.0	1.1	2.1	0.5	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	4.8	-1.3	-2.2
High blood pressure (siblings)	1.0	1.5	2.1	0.9	1.4
Medication: Ibuprofen	1.0	1.2	1.7	1.3	0.9
Medication: Paracetamol	1.0	1.6	1.8	1.3	1.2
Lupus	0.9	1.3	1.9	1.4	0.8
Chronotype (morning person)	0.9	2.0	2.8	-1.1	-1.7
Supplements: Glucosamine	0.9	1.1	1.7	-1.3	-0.7
Heart attack	0.9	1.1	2.2	-1.5	-0.2
Hair/balding pattern: Pattern 3	0.9	1.3	2.5	0.2	-1.6
Happiness	0.9	1.1	2.3	-0.2	1.5
Forced vital capacity (FVC), Best measure	0.9	3.3	4.3	-1.5	-2.1
Eye problems/disorders: Cataract	0.9	1.1	1.5	-1.2	-0.8
Hearing aid user	0.9	1.0	1.9	-0.2	1.4
Alcohol drinker status: Never	0.9	1.1	1.5	-1.2	-0.8
Alcohol drinker status: Previous	0.9	1.0	1.3	-0.9	-1.1
Arm predicted mass (left)	0.9	4.6	8.6	-2.9	-0.7
Ulcerative Colitis	0.8	1.2	2.3	-1.5	-0.1
Hypothyroidism (self reported)	0.8	1.8	3.2	-1.8	-0.6
Trunk fat-free mass	0.8	4.5	8.9	-3.0	-0.2
Trunk predicted mass	0.8	4.3	8.7	-2.9	-0.1
Glaucoma (self-reported)	0.8	1.0	1.8	-0.4	-1.3
Gout (self-reported)	0.8	1.0	1.1	1.0	1.0
Medication: Amlodipine	0.8	1.1	1.3	0.9	1.1
Heart disease (mother)	0.8	0.9	1.2	0.8	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.2	1.1	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.0	1.0	1.0
Smoking status: Previous	0.8	1.2	2.4	1.6	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	2.3	-1.1	-1.5
Average weekly red wine intake	0.8	1.2	1.5	-1.2	-0.9
Back pain experienced in last month	0.8	1.2	2.2	0.4	1.5
Arm fat-free mass (left)	0.8	4.3	8.1	-2.9	-0.7
Average weekly beer plus cider intake	0.8	1.2	1.3	1.2	1.0
Fasting Glucose	0.7	0.8	1.6	1.3	-0.1
Heel T-Score	0.7	5.4	7.6	1.8	2.8
Average weekly spirits intake	0.7	0.8	1.7	0.0	-1.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.1	1.0	1.0
Hearing difficulty/problems: Yes	0.7	1.0	2.0	0.2	1.4
Medication: Atenolol	0.7	0.8	1.6	1.3	-0.2
Nervous feelings	0.7	1.3	1.5	-1.1	-1.2
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.7	0.3	1.3
Worry too long after embarrassment	0.7	1.2	2.1	-1.4	-0.6
Arm predicted mass (right)	0.7	3.6	6.8	-2.6	-0.7
Ever had bowel cancer screening	0.7	0.8	1.3	1.1	0.6
Mineral and other dietary supplements	0.7	1.0	1.3	1.2	-0.8
Osteoarthritis (self-reported)	0.7	0.9	1.9	1.4	0.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.7	-0.0	1.3
Medication: Atorvastatin	0.7	0.8	1.7	-1.3	0.1
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.8	-1.3	-0.3
Bipolar Disorder (2018)	0.6	0.9	1.0	0.9	1.0
Worry (Nagel 2018)	0.6	1.4	1.8	-1.4	-1.0
Ovarian Cancer	0.6	0.8	1.2	-0.6	-1.1
Primary Biliary Cirrhosis	0.6	0.8	1.2	0.6	-1.1
Fed-up feelings	0.6	1.0	1.7	-0.6	1.3
Forced vital capacity (FVC)	0.6	2.5	3.5	-1.2	-1.9
Medication: Ramipril	0.6	0.8	1.5	-1.2	-0.1
Father’s age at death	0.6	0.8	0.8	0.8	0.9
Arm fat-free mass (right)	0.6	3.3	6.4	-2.5	-0.5
Qualifications: College or University degree	0.6	1.8	2.3	1.2	1.5
Mother’s age at death	0.6	0.8	1.3	0.5	1.1
Medication: Bendroflumethiazide	0.6	0.9	1.1	0.8	-1.1
Ever depressed for a whole week	0.6	0.7	1.2	1.1	0.5
Commuting to job workplace: Cycle	0.6	0.7	1.3	-1.1	-0.5
Pack years of smoking	0.6	0.9	1.0	-1.0	-0.9
Schizophrenia vs Biploar Disorder	0.5	0.7	1.2	-0.4	1.1
Ulcerative Colitis (UC)	0.5	0.9	1.2	-0.8	-1.1
Blood Platelet Count	0.5	6.3	10.4	-1.5	-3.2
Smoking Status	0.5	1.2	2.2	1.5	0.5
Cardiovascular Disease	0.5	1.8	1.9	1.3	1.4
Number of treatments/medications taken	0.5	0.8	1.2	0.7	1.1
Angina	0.5	0.6	1.2	-1.1	0.2
Vitamin and mineral supplements	0.5	0.7	0.8	0.9	0.8
Pack years adult smoking proportion	0.5	0.8	1.1	-1.1	-0.8
Townsend deprivation index at recruitment	0.5	0.8	1.5	0.2	-1.2
Serious illness, injury or assault to yourself	0.5	0.6	1.1	-1.1	0.4
Hayfever, allergic rhinitis or eczema	0.5	1.2	2.2	-1.5	-0.4
Hearing difficulty/problems with background noise	0.5	0.9	1.7	-0.0	1.3
Number of live births	0.5	0.7	1.3	-0.4	-1.1
Prospective memory result	0.5	0.6	0.8	0.9	-0.6
Emphysema/chronic bronchitis	0.5	0.6	1.2	1.1	0.2
Major Depression (MDD)	0.4	0.5	0.9	-0.1	-1.0
Neuroticism (2016)	0.4	0.6	0.6	0.8	-0.8
Schizophrenia (2014)	0.4	0.8	1.7	-0.0	1.3
Blood Eosinophil Count	0.4	2.7	4.5	0.9	2.1
Hand grip strength (left)	0.4	1.1	1.5	-1.2	-0.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.6	-0.8	0.6
Medication: Co-codamol	0.4	0.5	0.7	-0.5	-0.9
Multivitamins +/- minerals	0.4	0.6	0.6	-0.8	-0.7
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.6	-0.7	-0.7
Financial difficulties in last 2 years	0.4	0.6	1.1	-0.2	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.5	0.7	0.7
Length of working week for main job	0.4	0.4	0.8	-0.1	-0.9
Headache pain in last month	0.4	0.7	1.5	0.1	1.2
Eye problems/disorders: None of the above	0.4	0.5	0.7	0.5	0.8
Angina (self-reported)	0.4	0.5	0.9	-1.0	-0.1
Medication: Seretide 50 evohaler	0.4	0.5	0.9	-0.3	0.9
Family relationship satisfaction	0.4	0.6	0.8	-0.6	0.9
Supplements: Vitamin C	0.4	0.5	1.0	-1.0	0.0
Friendships satisfaction	0.4	0.5	0.7	-0.9	0.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	0.8	0.9	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.7	0.2	-1.3
Eye problems/disorders: Glaucoma	0.4	0.5	0.6	0.8	-0.6
Illnesses of father: High blood pressure	0.4	0.4	0.7	0.8	0.4
Ever smoked	0.4	0.8	1.1	1.1	0.7
Supplements: Calcium	0.4	0.4	0.6	-0.8	-0.4
Depressed Affect (Nagel 2018)	0.3	0.6	1.1	-1.0	-0.3
Crohns Disease (2017)	0.3	0.7	1.0	1.0	-0.6
Neuroticism	0.3	0.8	1.6	-1.3	0.1
Relative age of first facial hair	0.3	0.7	1.2	-0.4	-1.1
Current tobacco smoking	0.3	0.5	1.0	-1.0	-0.2
Relative age voice broke	0.3	0.4	0.8	0.9	0.3
Taking other prescription medications	0.3	0.5	0.9	0.4	1.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	0.5	-0.5	0.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.6	0.8	0.4
Fluid intelligence score	0.3	0.6	0.8	0.9	0.6
Alcohol intake versus 10 years previously	0.3	0.5	0.8	0.3	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.8	0.5	0.9
Lung cancer (father)	0.3	0.3	0.5	0.3	0.7
Number of children fathered	0.3	0.3	0.5	0.7	-0.2
Neck or shoulder pain in last month	0.3	0.4	0.7	0.2	0.8
Overall health rating	0.3	0.5	1.0	0.3	1.0
Miserableness	0.3	0.5	0.7	-0.5	0.9
Guilty feelings	0.3	0.4	0.7	-0.8	0.3
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.4	0.6	0.6
Depression (Nagel 2018)	0.2	0.3	0.6	0.8	0.1
Irritable Bowel Disease (IBD)	0.2	0.6	1.1	-0.2	-1.1
Crohns Disease (2012)	0.2	0.2	0.3	0.6	0.4
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.3	0.2	0.6
Systolic Blood Pressure	0.2	0.8	1.0	0.7	1.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.2	0.7
Stomach or abdominal pain in last month	0.2	0.2	0.3	-0.4	-0.5
Had menopause	0.2	0.2	0.4	-0.1	-0.6
Pain all over the body in last month	0.2	0.3	0.5	-0.1	-0.7
Worrier / anxious feelings	0.2	0.4	0.7	-0.8	-0.4
Medication: Cholesterol lowering	0.2	0.4	0.5	0.7	0.5
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	0.1	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.6	0.8	0.3
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.5	-0.7	0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	0.2	0.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.3	-0.5	-0.6
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	0.7	0.2
Number of full brothers	0.2	0.3	0.5	0.7	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	0.6	-0.2
Health satisfaction	0.2	0.2	0.4	-0.3	0.6
Alcohol intake frequency.	0.2	0.4	0.6	0.5	0.7
Suffer from ‘nerves’	0.2	0.3	0.5	-0.7	0.2
Had major operations	0.2	0.2	0.5	-0.7	0.1
Illnesses of father: Heart disease	0.2	0.3	0.5	0.2	-0.7
Commuting to job workplace: Walk	0.2	0.2	0.3	-0.3	-0.5
Medication for cholesterol	0.2	0.2	0.3	0.5	-0.4
Number of self-reported non-cancer illnesses	0.2	0.4	0.4	0.6	0.6
Wears glasses or contact lenses	0.2	0.3	0.5	-0.3	-0.7
Financial situation satisfaction	0.2	0.2	0.4	0.3	0.6
Commuting to job workplace: Public transport	0.2	0.2	0.4	-0.1	0.6
Medication: Blood pressure	0.2	0.4	0.7	0.4	0.8
Irritability	0.2	0.4	0.8	0.1	0.9
Diastolic blood pressure, automated reading	0.2	0.8	0.9	0.9	0.8
Unable to work because of sickness or disability	0.2	0.2	0.4	-0.6	-0.2
Bipolar Disorder or Schizophrenia	0.1	0.3	0.4	0.4	0.6
Neuroticism (Nagel 2018)	0.1	0.1	0.3	-0.5	0.1
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	-0.3	-0.4
Mean Putamen Volume	0.1	0.1	0.1	0.4	0.0
Rheumatoid Arthritis	0.1	0.2	0.3	0.5	-0.2
Blood White Count	0.1	1.0	1.1	0.9	1.1
Allergy or Eczema	0.1	0.3	0.5	-0.7	0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.0	0.5
Systolic blood pressure, automated reading	0.1	0.4	0.8	0.0	-0.9
Hand grip strength (right)	0.1	0.2	0.4	-0.7	-0.1
Qualifications: CSEs or equivalent	0.1	0.1	0.3	-0.0	0.5
High blood pressure	0.1	0.2	0.5	0.7	0.2
Alcohol usually taken with meals	0.1	0.2	0.4	-0.3	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	-0.1	-0.4
Allergy	0.1	0.2	0.4	0.6	-0.2
Neuroticism score	0.1	0.2	0.4	-0.6	0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.5	-0.7	-0.3
Exposure to tobacco smoke at home	0.1	0.2	0.3	0.5	0.2
Tense / ‘highly strung’	0.1	0.2	0.3	0.5	0.1
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	0.2	-0.8
Exposure to tobacco smoke outside home	0.1	0.1	0.2	0.2	-0.5
Age at first live birth	0.1	0.2	0.4	0.7	-0.1
Pulse wave peak to peak time	0.1	0.1	0.2	-0.5	0.2
Medication: Blood pressure	0.1	0.2	0.2	0.4	0.5
Age at last live birth	0.1	0.1	0.1	0.3	0.3
Leg pain on walking	0.1	0.1	0.1	0.4	-0.3
Knee pain experienced in last month	0.1	0.2	0.3	0.4	-0.5
Hypertension (Self-reported)	0.1	0.4	0.7	0.9	-0.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.1	-0.4	-0.0
Mood swings	0.1	0.2	0.4	-0.6	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.2	-0.5
Osteoporosis (self-reported)	0.1	0.2	0.2	-0.4	-0.5
Smoking status: Current	0.1	0.1	0.2	-0.4	0.3
Average weekly champagne plus white wine intake	0.1	0.1	0.1	0.3	0.3
Number of operations (self-reported)	0.1	0.2	0.2	-0.4	0.4
Schizophrenia (2018)	0.0	0.0	0.1	-0.3	-0.0
Age at First Birth	0.0	0.1	0.1	0.3	-0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Lung FVC	0.0	0.0	0.0	0.1	-0.2
Hair Pigment	0.0	0.9	1.7	-0.1	-1.3
Sensitivity / hurt feelings	0.0	0.0	0.0	-0.2	0.2
Severe depression (siblings)	0.0	0.0	0.0	0.0	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.0	-0.2	0.2
Medication: Levothyroxine sodium	0.0	0.0	0.1	-0.2	0.2
Illnesses of siblings	0.0	0.0	0.1	0.0	-0.3
Time employed in main current job	0.0	0.0	0.0	0.1	-0.0
Pulse rate	0.0	0.0	0.1	0.2	-0.1
Mouth/teeth dental problems: Dentures	0.0	0.0	0.0	0.2	0.1
Loud music exposure frequency	0.0	0.0	0.0	0.2	0.2
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	-0.2	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	-0.3	0.0
Pulse rate, automated reading	0.0	0.0	0.0	0.1	0.0
Loneliness, isolation	0.0	0.0	0.0	0.1	-0.1
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.0	0.0	0.2
Myopia	0.0	0.0	0.0	0.1	0.0
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	-0.5	-0.2

Hub : Genes

MAFF

Models

Trait associations