TWAS hub - TMEM184B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0790	0.0310	1.4e-03	0.076	NA	0.072	NA	0.075	8.5e-07	NA	1.7e-06	NA	1.0e-06
2	GTEx	Artery Aorta	0.1680	0.0550	9.5e-05	0.068	NA	0.027	NA	0.024	1.3e-04	NA	1.2e-02	NA	1.7e-02
3	GTEx	Brain Cortex	0.2910	0.1100	3.1e-03	0.119	NA	0.053	NA	0.093	3.6e-04	NA	1.4e-02	NA	1.6e-03
4	GTEx	Brain Putamen basal ganglia	0.5740	0.1360	6.6e-03	0.156	NA	0.140	NA	0.228	1.5e-04	NA	3.5e-04	NA	3.9e-06
5	GTEx	Cells Transformed fibroblasts	0.1690	0.0530	9.2e-07	0.159	NA	0.097	NA	0.136	5.1e-12	NA	1.0e-07	NA	2.1e-10
6	GTEx	Colon Sigmoid	0.1980	0.0820	4.0e-03	0.027	NA	-0.006	NA	-0.005	3.8e-02	NA	6.0e-01	NA	5.4e-01
7	GTEx	Esophagus Muscularis	0.1130	0.0480	1.9e-03	0.014	NA	0.056	NA	0.049	4.5e-02	NA	2.7e-04	NA	6.4e-04
8	GTEx	Nerve Tibial	0.1556	0.0500	3.0e-05	0.117	NA	0.130	NA	0.141	1.3e-08	NA	1.9e-09	NA	3.6e-10
9	GTEx	Thyroid	0.1870	0.0450	7.3e-10	0.161	NA	0.156	NA	0.180	2.2e-12	NA	5.5e-12	NA	1.0e-13
10	YFS	Blood	0.0897	0.0200	0.0e+00	0.071	0.087	0.090	0.088	0.088	2.6e-22	5.0e-27	7.8e-28	2e-27	2.2e-27
11	TCGA	Kidney Renal Clear Cell Carcinoma	0.0281	0.0152	4.7e-03	0.033	0.013	0.034	NA	0.035	1.2e-04	1.1e-02	9.2e-05	NA	7.7e-05
12	TCGA	Thyroid Carcinoma	0.0340	0.0200	6.5e-03	0.042	0.021	0.032	NA	0.037	5.3e-05	3.6e-03	4.2e-04	NA	1.6e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Trunk fat percentage	10.1	40.6	79.3	-6.6	-8.4	-8.9	-2.4	-6.2	-5.5	-6.4	-5.7	-7.2	-6.0	-5.4	-5.4
Breast Cancer	9.8	23.6	38.1	-5.7	-5.3	-4.9	-1.6	-4.8	-4.9	-5.2	-4.6	-6.2	-4.8	-4.3	-4.5
Trunk fat mass	8.7	37.6	64.3	-6.5	-7.5	-8.0	-2.8	-6.1	-5.5	-6.5	-5.8	-7.1	-5.3	-5.5	-5.4
Body fat percentage	8.3	32.7	63.5	-5.8	-7.7	-8.0	-2.3	-5.5	-4.9	-5.8	-5.1	-6.4	-5.4	-4.9	-4.8
Whole body fat mass	7.6	31.6	52.9	-5.9	-6.9	-7.3	-2.8	-5.5	-5.0	-6.0	-5.3	-6.4	-4.9	-5.0	-4.9
Arm fat percentage (right)	6.4	25.2	44.0	-5.2	-6.6	-6.3	-1.9	-4.9	-4.5	-5.4	-4.6	-5.7	-4.7	-4.4	-4.4
Arm fat percentage (left)	6.4	25.5	45.0	-5.2	-6.7	-6.4	-1.9	-4.8	-4.5	-5.6	-4.6	-5.7	-4.8	-4.3	-4.3
Leg fat mass (right)	5.8	22.5	37.7	-5.1	-5.8	-6.1	-2.9	-4.7	-4.1	-5.3	-4.5	-5.5	-3.8	-4.2	-4.2
Arm fat mass (right)	5.6	23.2	31.6	-5.2	-5.5	-5.6	-2.5	-4.8	-4.4	-5.5	-4.7	-5.6	-4.1	-4.5	-4.4
Leg fat mass (left)	5.6	21.7	35.5	-5.0	-5.6	-6.0	-2.6	-4.6	-4.1	-5.1	-4.5	-5.4	-3.7	-4.3	-4.1
Arm fat mass (left)	5.3	21.7	29.8	-5.0	-5.2	-5.5	-2.6	-4.7	-4.3	-5.2	-4.6	-5.4	-4.0	-4.4	-4.2
Weight	4.8	23.5	34.4	-5.5	-4.8	-5.3	-2.7	-5.0	-4.6	-5.3	-5.0	-5.9	-3.8	-4.8	-4.7
Mouth/teeth dental problems: Loose teeth	4.3	5.1	7.1	2.6	1.7	1.4	1.9	2.5	2.1	2.7	2.6	2.6	2.1	2.4	2.4
Leg fat percentage (right)	4.2	15.1	31.5	-3.9	-5.4	-5.6	-1.6	-3.7	-3.1	-4.1	-3.5	-4.2	-3.4	-3.3	-3.2
Leg fat percentage (left)	4.0	14.3	28.9	-3.8	-5.2	-5.4	-1.5	-3.6	-3.1	-3.9	-3.4	-4.1	-3.5	-3.3	-3.1
Body Mass Index (BMI) (2010)	3.7	5.1	9.6	-1.9	-2.2	-3.1	-2.5	-2.0	-1.9	-2.4	-2.1	-2.3	-2.4	-2.2	-1.8
Triglycerides	3.7	6.0	22.3	2.7	1.7	4.7	2.3	2.2	1.6	2.4	1.7	3.3	1.5	1.6	1.7
Hip circumference	3.5	14.9	26.5	-4.0	-5.2	-4.8	-1.2	-3.7	-3.5	-4.2	-3.8	-4.5	-2.8	-3.8	-3.4
Impedance of arm (right)	3.4	15.6	49.4	-3.5	-7.0	-6.9	-0.1	-3.3	-2.5	-2.7	-2.5	-4.1	-4.3	-2.5	-2.5
Medication: Paracetamol	3.4	5.7	7.8	2.7	1.3	2.8	0.9	2.7	2.2	2.3	2.8	2.8	2.1	2.5	2.6
Diabetes (self-reported)	3.3	5.1	10.3	2.5	2.7	3.0	0.3	2.4	1.4	3.2	1.9	2.6	1.4	2.0	2.1
Birth weight of first child	3.2	5.9	13.3	-2.7	-1.8	-2.9	-0.5	-2.6	-2.5	-3.6	-1.9	-2.8	-2.1	-1.8	-2.4
Leg fat-free mass (left)	3.1	16.6	25.3	-4.7	-3.0	-3.8	-2.4	-4.3	-4.1	-5.0	-4.4	-5.0	-3.0	-4.2	-4.1
Leg predicted mass (left)	3.1	16.2	24.7	-4.6	-3.1	-3.8	-2.3	-4.2	-4.1	-5.0	-4.4	-5.0	-2.9	-4.1	-4.0
Comparative height size at age 10	3.1	16.9	28.6	-4.9	-4.1	-5.1	-2.5	-4.1	-3.5	-4.3	-3.8	-5.3	-3.3	-3.9	-3.7
Had other major operations	2.9	3.5	5.2	2.0	1.1	1.7	0.3	2.1	1.6	1.9	2.3	2.1	2.0	2.2	2.1
Coronary Artery Disease (CAD)	2.8	3.3	7.5	-2.0	-0.7	-1.8	-0.4	-2.1	-2.0	-2.7	-1.8	-1.8	-2.2	-1.2	-1.8
Shortness of breath walking on level ground	2.8	3.3	6.9	-1.8	-2.6	-2.5	0.2	-1.9	-1.9	-1.8	-1.7	-1.8	-1.4	-1.5	-1.7
BMI	2.7	15.9	24.5	-4.3	-4.9	-3.8	-2.8	-4.0	-3.7	-4.6	-4.1	-4.5	-2.9	-3.8	-3.8
Age when periods started (menarche)	2.7	6.4	11.5	2.6	1.7	1.9	2.3	2.5	2.5	2.9	2.6	2.6	3.4	2.7	2.3
Impedance of arm (left)	2.7	12.5	44.2	-2.9	-6.5	-6.7	0.1	-2.7	-1.9	-2.4	-1.9	-3.5	-4.0	-1.8	-1.9
LDL Cholesterol	2.6	4.0	7.0	2.5	2.2	2.2	0.4	2.0	1.6	2.6	1.8	2.5	1.4	1.9	1.9
Diabetes (mother)	2.5	3.2	4.3	1.8	1.8	1.8	1.4	2.0	1.8	1.3	1.9	1.8	2.1	1.8	2.0
Leg predicted mass (right)	2.5	13.2	20.6	-4.2	-2.3	-3.1	-2.5	-3.8	-3.8	-4.4	-4.0	-4.5	-2.7	-3.8	-3.7
Alzheimer’s Disease (in father)	2.4	2.6	5.2	1.8	1.5	2.3	1.3	1.7	1.5	1.8	1.3	2.1	1.3	1.0	1.4
Hypothyroidism (self reported)	2.4	5.4	8.8	-2.7	-3.0	-0.9	0.4	-2.7	-2.9	-1.8	-2.6	-2.5	-1.5	-2.5	-2.7
Birth weight	2.4	5.2	11.4	-2.6	-2.5	-3.4	-0.9	-2.1	-1.7	-2.1	-1.8	-3.1	-2.4	-1.7	-1.9
Mean time to correctly identify matches	2.4	4.5	9.1	2.1	2.4	1.2	-0.2	2.2	1.9	3.0	2.3	2.3	2.2	2.5	1.9
Leg fat-free mass (right)	2.4	13.0	20.3	-4.1	-2.3	-3.1	-2.4	-3.8	-3.7	-4.5	-4.0	-4.5	-2.7	-3.8	-3.6
HDL Cholesterol	2.3	3.8	7.5	-2.2	-1.7	-2.7	-1.5	-1.9	-1.5	-1.3	-1.8	-2.4	-2.2	-1.9	-1.7
Waist circumference	2.3	8.3	11.2	-3.1	-3.3	-2.8	-1.4	-2.9	-2.9	-3.3	-3.1	-3.2	-2.1	-3.1	-2.7
Deep venous thrombosis (DVT) (self-reported)	2.3	2.9	9.0	-1.8	-2.8	-3.0	-0.5	-1.4	-1.0	-2.4	-1.0	-1.8	-0.5	-0.7	-1.0
Ever had hysterectomy (womb removed)	2.2	2.5	4.4	-2.0	-1.7	-1.4	-0.8	-1.7	-1.5	-1.4	-1.7	-2.1	-1.0	-1.6	-1.6
Maternal smoking around birth	2.2	3.1	4.5	2.0	1.3	1.1	-0.2	2.1	1.9	2.0	1.9	2.1	1.7	1.8	2.1
Body mass index (BMI)	2.2	9.4	14.2	-3.3	-3.1	-3.2	-1.8	-3.1	-3.0	-3.8	-3.2	-3.5	-2.5	-2.9	-2.9
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	5.9	-1.6	-1.9	-2.1	-0.4	-1.4	-1.6	-2.4	-1.3	-1.5	-1.3	-1.2	-1.4
Past tobacco smoking	2.1	3.9	8.7	-2.2	-1.0	0.1	-1.1	-2.1	-1.9	-2.9	-2.4	-2.3	-1.6	-2.1	-2.1
Medication for pain relief, constipation, heartburn	2.1	3.6	7.0	-2.1	-1.3	-2.6	-1.3	-2.1	-1.8	-1.4	-2.0	-2.1	-1.7	-1.7	-2.1
Sitting height	2.0	14.0	24.3	-4.5	-1.1	-4.3	-1.8	-4.2	-3.3	-2.7	-4.4	-4.9	-3.0	-4.6	-3.8
Blood clot in the leg (DVT)	2.0	2.6	8.7	-1.6	-2.7	-3.0	-0.6	-1.3	-0.9	-2.2	-0.9	-1.7	-0.5	-0.6	-0.9
Chest pain or discomfort	2.0	2.9	10.0	1.9	0.7	1.4	3.2	1.6	1.4	2.1	1.5	1.8	0.5	1.6	1.6
Diabetes diagnosed by doctor	2.0	3.2	9.3	1.7	2.8	3.0	-0.8	1.6	0.7	2.4	1.2	1.9	0.9	1.3	1.3
Mouth/teeth dental problems	1.9	3.0	5.5	-1.8	-1.7	-0.7	-0.6	-1.7	-1.6	-1.7	-1.9	-1.9	-2.3	-2.0	-1.7
Breast cancer (self-reported)	1.9	2.2	7.0	2.0	1.1	1.2	2.6	1.1	1.2	1.7	1.0	2.0	0.3	1.1	1.1
Basal metabolic rate	1.9	10.5	16.5	-3.8	-1.9	-2.5	-2.3	-3.4	-3.3	-4.0	-3.7	-4.1	-1.9	-3.6	-3.3
Medication: Ibuprofen	1.8	2.1	3.9	1.4	1.0	1.9	-0.9	1.5	1.1	2.0	1.5	1.5	1.9	0.9	1.4
Osteoarthritis (self-reported)	1.8	2.3	4.5	1.8	-0.2	0.0	0.3	1.7	1.5	1.8	1.9	1.5	2.1	1.7	1.8
Medication: Aspirin	1.8	2.3	5.8	1.5	1.8	2.4	2.3	1.5	1.3	0.7	1.1	1.6	0.8	1.1	1.4
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	3.5	-1.4	-1.7	-1.8	0.9	-1.5	-1.4	-1.2	-1.5	-1.5	-1.9	-1.4	-1.3
Reaction Time	1.7	3.3	8.2	1.9	1.6	1.4	0.1	1.8	1.5	2.9	1.8	1.9	2.0	2.1	1.5
Smoking Status	1.7	4.2	8.9	2.4	1.4	-0.4	0.7	2.4	2.3	3.0	2.5	2.2	0.9	1.9	2.5
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.8	11.3	1.8	3.4	3.1	0.3	1.8	1.8	1.5	1.2	1.8	1.5	1.7	1.7
Mouth/teeth dental problems: Bleeding gums	1.7	2.1	3.9	1.6	0.6	1.4	0.5	1.4	1.6	1.8	1.7	1.5	1.5	2.0	1.4
Risk taking	1.7	2.5	4.3	2.1	2.0	1.3	-0.4	1.9	1.5	0.9	1.8	1.9	0.8	1.8	1.8
Average weekly fortified wine intake	1.6	1.9	7.3	-1.3	-2.7	-0.7	0.8	-1.3	-1.1	-0.1	-1.2	-1.5	-1.8	-1.3	-1.2
Multivitamins +/- minerals	1.6	2.1	3.7	-1.6	-1.8	-0.1	-0.5	-1.6	-1.9	-0.7	-1.6	-1.6	-1.1	-1.7	-1.7
Falls in the last year	1.6	2.1	5.3	-1.5	-1.5	-2.3	-0.1	-1.4	-1.4	-2.1	-0.8	-1.7	-1.6	-0.4	-1.1
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	4.4	2.0	0.9	0.4	1.3	1.6	1.3	1.4	1.4	2.1	0.3	0.5	1.7
Lung cancer (father)	1.6	1.9	3.5	1.4	1.6	0.5	-0.1	1.6	1.6	1.1	1.5	1.4	1.3	1.9	1.6
Standing height	1.6	15.9	27.4	-4.8	-3.7	-4.8	-2.0	-4.2	-3.5	-3.6	-4.1	-5.2	-2.6	-4.2	-3.8
Mood swings	1.6	2.8	4.5	-1.9	-0.7	0.2	0.1	-2.0	-2.1	-1.9	-1.9	-1.8	-1.7	-1.9	-2.0
Average weekly beer plus cider intake	1.6	2.4	3.4	1.7	1.6	0.4	1.3	1.9	1.7	1.8	1.4	1.6	0.3	1.8	1.8
Ulcerative Colitis	1.5	2.1	3.6	-1.5	-1.0	0.2	0.9	-1.5	-1.4	-1.9	-1.8	-1.3	-1.8	-1.7	-1.6
Hearing difficulty/problems: Yes	1.5	2.2	16.5	1.0	4.1	2.0	0.4	0.9	1.0	-0.6	0.4	0.9	0.3	0.9	0.9
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	3.4	1.2	1.0	1.8	-1.5	1.3	0.9	1.6	1.5	1.2	1.9	1.0	1.2
Medication: Lansoprazole	1.5	1.7	3.5	-1.3	-1.7	-1.9	-0.1	-1.1	-1.2	-0.9	-1.1	-1.5	-1.7	-1.0	-1.1
Respiratory disease	1.4	3.0	6.8	1.7	2.3	2.6	1.5	1.6	0.6	2.2	1.4	1.8	1.7	1.2	1.3
Breastfed as a baby	1.4	1.7	4.5	1.4	1.0	1.8	1.1	1.1	0.7	2.1	1.1	1.2	1.3	1.4	1.0
Medication: Omeprazole	1.4	1.7	3.0	-1.4	-1.7	-1.7	1.1	-1.3	-1.1	-0.8	-1.3	-1.4	-1.5	-1.0	-1.1
Handedness (chirality/laterality): Left-handed	1.4	1.7	7.0	-1.0	1.0	-0.2	-2.6	-1.0	-0.8	-1.3	-1.1	-1.0	-1.8	-1.1	-1.0
Blood Red Count	1.3	12.1	50.7	3.5	4.4	7.1	1.7	2.9	2.3	3.4	2.1	3.8	2.6	1.9	2.3
Wheeze or whistling in the chest in last year	1.3	2.3	4.2	1.8	1.0	1.3	2.0	1.5	0.9	1.4	1.7	1.9	1.4	1.6	1.3
Number of full sisters	1.3	1.6	4.9	-1.0	-1.6	-2.2	0.5	-0.8	-1.0	-1.9	-0.7	-1.1	-1.9	-0.4	-0.6
High cholesterol (Self-reported)	1.3	2.3	3.5	1.9	1.3	1.2	1.5	1.8	1.6	0.8	1.7	1.8	0.3	1.5	1.8
Alcohol drinker status: Previous	1.3	1.5	4.7	-0.9	-1.8	-1.6	-0.1	-1.0	-0.8	-1.2	-1.0	-0.9	-2.2	-1.2	-0.7
Impedance of whole body	1.3	6.8	29.6	-1.9	-5.2	-5.4	0.1	-1.7	-0.9	-0.9	-1.1	-2.3	-2.9	-1.2	-1.0
Intelligence (Savage-Jansen 2018)	1.2	3.6	10.3	1.8	2.2	2.6	3.2	1.7	1.1	2.5	1.1	1.9	0.3	1.0	1.4
Verbal and Numeric Reasoning (VNR)	1.2	2.8	5.3	1.7	1.9	1.9	2.3	1.9	1.5	1.6	1.4	1.8	0.6	1.2	1.7
Prostate Cancer	1.2	1.7	3.9	1.4	1.8	0.8	1.4	1.3	1.0	2.0	1.0	1.4	0.8	1.1	1.2
Height	1.2	23.0	50.7	-5.8	-4.3	-7.1	-1.1	-5.0	-4.0	-4.4	-4.3	-6.3	-3.3	-4.8	-4.5
Tanning	1.2	14.8	40.1	-4.4	-3.9	-6.3	-1.5	-4.1	-3.1	-2.5	-3.4	-5.0	-2.8	-3.2	-3.5
Medication: Co-codamol	1.2	1.4	2.3	-0.9	-1.2	-0.8	0.2	-1.3	-1.1	-1.5	-1.3	-1.1	-1.5	-1.2	-1.1
Medication: Simvastatin	1.2	1.7	2.7	1.6	1.2	1.3	1.3	1.5	1.3	1.2	1.3	1.6	0.6	1.2	1.4
Medication: Aspirin	1.2	1.5	4.2	1.2	1.5	2.0	2.0	1.1	0.9	0.5	0.9	1.2	0.3	0.8	1.1
Whole body fat-free mass	1.2	6.6	11.1	-3.1	-0.7	-1.3	-2.1	-2.7	-2.7	-3.3	-3.0	-3.3	-1.1	-3.0	-2.8
Ever had bowel cancer screening	1.2	1.4	2.7	1.1	0.5	0.6	1.1	1.3	1.3	1.3	1.1	1.3	1.6	1.1	1.2
Eye problems/disorders: Cataract	1.2	1.4	3.0	-1.4	-0.5	-0.7	0.8	-1.4	-1.7	-0.8	-1.2	-1.2	-1.2	-1.3	-1.5
Medication: Paracetamol	1.2	1.9	3.1	1.7	-0.1	1.4	1.2	1.6	1.0	1.3	1.8	1.7	1.3	1.3	1.4
Worry (Nagel 2018)	1.1	2.3	4.4	-1.9	-2.1	-0.8	-0.0	-1.6	-1.9	-1.8	-1.1	-1.4	-1.6	-1.0	-1.6
Ulcerative Colitis (UC)	1.1	2.0	3.3	-1.5	-1.7	-0.4	0.1	-1.6	-1.4	-1.4	-1.8	-1.3	-1.5	-1.8	-1.5
Medication: Metformin	1.1	1.5	7.2	0.8	2.0	2.7	-0.7	0.9	-0.1	1.5	0.3	1.0	0.6	0.8	0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	6.2	1.6	2.5	2.4	1.0	1.4	1.4	1.1	1.2	1.6	1.3	1.5	1.4
Exposure to tobacco smoke at home	1.1	1.3	1.9	1.2	1.0	0.7	0.8	1.2	1.4	0.6	1.3	1.2	1.2	1.2	1.2
Exposure to tobacco smoke outside home	1.1	1.4	6.2	-1.0	-0.8	-1.1	-2.5	-1.1	-1.0	-0.9	-1.1	-1.1	-1.0	-0.8	-1.1
Whole body water mass	1.1	6.5	10.9	-3.0	-0.7	-1.3	-2.1	-2.7	-2.7	-3.3	-3.0	-3.2	-1.0	-2.9	-2.7
Eye problems/disorders: Glaucoma	1.1	1.3	3.4	1.4	-1.2	-0.6	0.6	1.2	1.8	0.3	1.3	1.1	0.3	0.9	1.5
Number of operations (self-reported)	1.1	1.6	3.2	1.3	0.6	1.1	1.2	1.6	1.3	0.8	1.6	1.0	0.6	1.4	1.8
Rheumatoid Arthritis	1.0	1.4	4.0	-1.1	-2.0	-0.3	1.3	-1.1	-1.2	-1.3	-1.1	-0.8	-0.9	-1.1	-1.2
Supplements: Glucosamine	1.0	1.4	2.5	-1.4	-1.6	-0.8	0.1	-1.3	-1.4	-1.4	-1.0	-1.3	-0.8	-0.7	-1.3
Medication: Levothyroxine sodium	1.0	1.8	3.7	-1.5	-1.3	-0.6	0.0	-1.6	-1.9	-0.5	-1.7	-1.3	-1.0	-1.5	-1.6
Nervous feelings	1.0	1.9	3.1	-1.8	-1.4	-0.9	0.4	-1.6	-1.6	-1.2	-1.3	-1.5	-1.1	-1.4	-1.7
Illnesses of mother	1.0	1.2	4.1	-0.9	-1.2	-2.0	-0.1	-1.1	-0.9	-1.4	-0.5	-1.0	-1.2	-0.6	-0.9
High blood pressure (siblings)	1.0	1.5	6.5	1.2	1.4	1.4	2.5	0.9	0.6	0.6	0.9	1.3	0.4	1.1	0.9
Qualifications: College or University degree	1.0	3.2	6.5	1.7	1.6	2.5	2.6	1.6	1.4	2.4	1.5	1.8	1.5	0.9	1.3
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.1	-1.2	-0.7	-0.8	-0.3	-1.3	-0.7	-1.8	-1.4	-1.1	-1.4	-1.0	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	5.5	-0.9	-1.2	-2.3	0.5	-0.5	-0.0	-1.4	-0.5	-1.4	-0.9	-0.1	-0.2
Smoking status: Previous	1.0	1.5	6.2	1.2	0.5	-0.2	0.2	1.1	1.1	2.5	1.4	1.3	1.3	1.2	1.2
Pain type(s) experienced in last month: Hip pain	1.0	1.2	5.9	0.9	0.9	1.1	2.4	0.9	0.6	1.4	0.6	0.9	0.9	0.6	0.8
Ever smoked	1.0	1.7	3.3	1.6	0.6	-0.3	0.2	1.5	1.2	1.8	1.7	1.7	1.2	1.3	1.4
Pack years of smoking	1.0	1.4	4.2	-0.9	-1.6	-1.3	-0.3	-0.7	-1.0	-2.0	-0.7	-1.1	-2.0	-0.2	-0.7
Pack years adult smoking proportion	0.9	1.4	4.5	-0.9	-1.7	-1.2	0.0	-0.6	-0.9	-2.1	-0.7	-1.0	-2.0	-0.2	-0.6
Hearing difficulty/problems with background noise	0.9	1.5	8.1	0.7	2.9	1.8	0.3	0.7	0.8	-0.8	0.8	0.7	0.4	1.3	0.8
Asthma	0.9	1.7	7.8	1.0	2.4	2.8	0.5	0.9	0.1	1.2	0.9	1.1	1.0	0.5	0.5
Glaucoma (self-reported)	0.9	1.1	2.2	1.2	-1.4	-1.5	0.3	1.0	1.4	-0.4	1.1	0.8	0.0	0.6	1.3
Number of children fathered	0.9	1.0	1.9	0.8	1.4	0.2	-0.8	0.9	1.3	0.8	1.3	0.7	0.7	1.4	1.1
Qualifications: nursing, teaching	0.9	1.4	4.4	-1.0	-2.1	-1.5	0.6	-1.1	-1.2	-0.5	-1.0	-1.0	-0.9	-1.3	-1.1
Asthma (self-reported)	0.9	1.7	7.9	1.0	2.4	2.8	0.4	0.8	0.0	1.1	0.9	1.1	1.1	0.4	0.5
Medication: Gliclazide	0.9	1.1	3.4	1.2	0.2	0.7	0.5	1.2	0.3	1.8	1.0	1.4	0.9	0.9	1.0
Smoking status: Current	0.9	1.5	3.0	1.5	0.8	-0.1	0.1	1.7	1.6	0.7	1.6	1.3	0.3	1.3	1.7
Commuting to job workplace: Public transport	0.9	1.1	1.8	1.0	0.5	1.0	1.1	1.3	1.2	0.4	1.2	0.8	1.0	1.1	1.2
Illnesses of father: High blood pressure	0.9	1.1	9.6	0.6	-0.1	0.9	3.1	0.8	0.8	0.2	0.3	0.4	0.3	0.1	0.8
Cholesterol lowering medication	0.9	1.4	3.4	1.0	1.8	1.3	1.8	1.0	0.9	0.2	1.0	1.2	-0.8	1.2	1.0
HbA1C	0.8	0.9	2.9	0.6	-0.8	-0.3	1.7	0.7	0.9	1.2	1.0	0.8	0.8	1.0	0.8
Fluid intelligence score	0.8	1.7	8.0	1.0	1.4	1.2	2.8	1.2	1.0	1.4	0.6	1.0	0.5	0.4	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.8	1.4	0.5	0.6	1.2	1.2	1.2	0.7	1.3	1.2	0.8	1.7	1.3
Peak expiratory flow (PEF)	0.8	1.7	7.2	-1.2	-1.7	-2.7	1.1	-1.2	-0.1	-1.3	-0.7	-1.7	-1.0	-0.6	-0.7
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	4.0	-1.2	-2.0	-0.3	0.1	-1.4	-1.7	-0.5	-1.4	-1.2	-0.7	-1.4	-1.4
Health satisfaction	0.8	1.1	2.8	-0.9	-0.4	1.0	0.9	-1.2	-1.7	-0.7	-1.3	-0.9	-0.8	-0.8	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	2.1	1.4	-0.3	0.8	1.1	1.3	0.8	0.5	1.4	1.4	1.1	1.3	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	5.8	-0.1	-1.1	-2.4	-1.8	-0.2	0.1	-0.8	0.2	-0.5	-0.8	-0.1	0.0
Hearing aid user	0.8	0.9	5.2	0.7	2.3	1.5	0.3	0.7	0.4	-0.5	0.4	0.6	0.1	0.8	0.7
Ever depressed for a whole week	0.8	0.9	1.6	1.3	0.9	0.9	-0.5	1.0	1.1	0.3	1.0	1.2	0.8	0.9	1.1
Heel T-Score	0.7	5.9	20.2	1.9	4.5	4.0	-1.2	1.9	2.4	0.4	1.8	1.9	1.7	2.2	2.1
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.9	1.1	0.6	0.9	1.2	0.8	0.4	1.0	1.3	1.3	0.9	1.4	0.6
Vitamin and mineral supplements	0.7	1.0	3.2	1.0	1.8	0.3	0.1	1.0	1.3	0.7	1.0	1.1	0.3	1.0	1.0
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.6	-0.5	-1.2	-0.9	0.8	-0.7	-0.6	-1.6	-0.7	-0.6	-1.4	-1.1	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.4	1.2	0.2	0.5	1.5	1.1	1.2	0.5	1.3	1.1	0.3	1.5	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	3.1	1.1	-0.6	-0.2	0.9	1.1	0.9	0.0	1.2	0.9	-0.4	1.8	1.2
Migraine (self-reported)	0.7	0.9	3.3	1.2	0.6	0.2	1.8	0.9	0.8	1.2	0.7	0.9	-0.1	0.5	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	4.3	1.1	0.3	0.0	2.1	0.7	0.6	0.7	0.9	1.3	-0.4	0.7	0.7
Arm predicted mass (right)	0.7	3.4	6.7	-2.2	0.1	-0.5	-1.7	-1.9	-2.0	-2.6	-2.2	-2.3	-0.3	-2.2	-2.0
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.4	1.2	1.5	1.1	0.8	0.7	0.5	1.2	0.5	1.1	0.1	0.4	0.6
Long-standing illness, disability or infirmity	0.7	1.1	4.5	0.9	-0.0	1.5	1.6	0.9	0.2	2.1	0.8	0.9	0.4	0.8	0.6
Medication for cholesterol	0.7	1.0	2.2	1.0	0.3	-0.6	-1.3	1.0	1.1	1.5	0.8	0.8	1.5	0.6	1.0
Ever taken oral contraceptive pill	0.7	0.8	2.0	1.1	1.0	1.3	0.6	0.8	0.4	1.4	-0.0	1.0	-0.6	-0.8	0.6
Heart disease (siblings)	0.7	0.9	5.3	-0.4	-0.6	-2.3	-1.5	-0.5	-0.1	-0.8	-0.4	-0.7	-1.1	-0.3	-0.2
Bipolar Disorder (2018)	0.6	0.9	3.2	0.6	1.4	1.6	1.8	0.7	0.7	0.5	0.5	0.8	-0.7	0.5	0.6
Depressed Affect (Nagel 2018)	0.6	1.3	2.9	-1.4	-1.5	0.3	-0.0	-1.2	-1.4	-1.7	-1.0	-1.1	-0.1	-1.1	-1.2
Ovarian Cancer	0.6	0.8	1.6	-0.9	-0.4	-0.7	1.1	-1.0	-1.0	-0.5	-1.1	-1.0	-0.4	-1.3	-1.1
Crohns Disease (2012)	0.6	1.0	3.6	1.0	1.9	0.3	0.9	0.9	1.2	0.3	0.7	0.7	0.9	0.9	1.0
Cardiovascular Disease	0.6	1.9	11.4	1.2	-0.1	2.0	3.4	1.0	0.7	0.6	0.9	1.4	0.7	0.6	1.0
Type 2 Diabetes (T2D) (2018)	0.6	1.2	4.1	0.8	1.6	2.0	0.7	0.6	-0.2	2.0	0.2	1.1	0.6	0.4	0.3
Lung FEV1/FVC ratio	0.6	3.2	12.5	-2.0	-3.5	-2.1	-0.3	-1.7	-0.9	-1.6	-1.4	-2.2	-1.0	-1.5	-1.4
Chronotype (morning person)	0.6	1.4	2.5	-1.3	-1.6	-1.4	-0.3	-1.3	-0.9	-1.3	-1.4	-1.3	-0.5	-1.3	-1.1
High blood pressure (mother)	0.6	0.8	4.4	0.3	1.0	2.1	1.3	0.4	0.3	1.1	0.2	0.7	0.8	0.2	0.4
Had menopause	0.6	0.7	2.0	-0.9	-1.4	-1.1	0.9	-0.7	-0.9	0.1	-0.6	-0.8	-0.9	-0.4	-0.8
Qualifications: None of the above	0.6	1.2	6.2	-1.1	-0.9	-2.5	-1.5	-0.7	-0.6	-1.4	-0.2	-1.0	-0.1	0.1	-0.5
Medication: Ramipril	0.6	0.8	1.9	-1.1	0.6	0.2	0.6	-0.8	-0.5	-1.4	-0.9	-1.0	-1.0	-1.1	-0.8
Trunk fat-free mass	0.6	3.2	5.5	-2.2	0.5	-0.0	-1.6	-1.8	-1.9	-2.4	-2.2	-2.2	-0.0	-2.3	-2.0
Happiness	0.6	0.7	3.7	0.0	-0.5	1.8	1.9	-0.1	-0.6	0.0	-0.1	0.4	0.9	0.0	-0.4
Medication: Cholesterol lowering	0.6	0.9	2.9	1.0	1.2	0.7	1.7	0.9	0.8	0.8	0.7	0.7	0.2	0.9	0.9
Loud music exposure frequency	0.6	0.6	1.4	1.2	-0.4	-0.1	1.1	0.8	0.7	0.0	0.9	1.0	0.1	1.0	0.9
Medication: Ventolin 100micrograms inhaler	0.6	0.8	5.0	-0.4	0.2	1.0	2.2	-0.6	-1.0	-0.5	-0.4	-0.0	0.5	-0.8	-0.7
Emphysema/chronic bronchitis	0.6	0.7	1.7	0.9	-0.1	0.1	0.5	0.9	0.7	1.0	1.3	1.1	0.6	1.2	0.8
Neck or shoulder pain in last month	0.6	0.8	3.1	0.9	0.9	0.4	-0.2	0.7	0.7	1.8	0.6	0.6	1.5	0.7	0.7
Heart disease (mother)	0.6	0.7	2.2	0.6	1.3	1.5	0.1	0.8	0.4	1.4	0.7	0.5	0.2	0.5	0.6
Supplements: Vitamin C	0.6	0.7	1.7	-0.8	-0.3	0.1	0.7	-0.9	-1.0	-1.3	-1.2	-0.8	-0.1	-0.7	-1.0
Illnesses of father: Heart disease	0.6	0.8	2.0	-0.7	-0.6	-0.9	1.4	-0.8	-0.8	-0.2	-1.1	-1.0	-1.2	-0.9	-0.8
Illnesses of siblings: Diabetes	0.6	0.8	3.9	0.7	2.0	1.3	-0.7	0.6	0.2	0.7	0.7	0.8	0.3	0.6	0.4
Friendships satisfaction	0.6	0.8	2.3	-0.5	0.0	1.5	1.4	-0.7	-1.5	-0.2	-0.9	-0.4	-0.3	-0.6	-1.0
Back pain experienced in last month	0.6	0.8	2.8	0.9	-0.1	0.8	1.7	0.9	0.6	0.7	1.0	0.9	0.9	0.9	0.8
Illnesses of father: None of the above (group 1)	0.6	0.8	7.0	-0.3	-0.6	-1.0	-2.6	-0.1	-0.3	-0.7	0.3	-0.3	0.3	0.4	-0.1
Number of self-reported non-cancer illnesses	0.6	1.0	8.4	0.8	-0.4	0.6	2.9	0.8	0.2	0.4	0.6	0.7	0.0	0.5	0.7
Tinnitus: Yes, now most or all of the time	0.6	0.7	4.0	1.0	2.0	0.5	-0.0	0.8	0.7	-0.1	0.6	0.8	-0.5	0.4	0.7
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.2	-1.0	-1.0	0.1	1.5	-1.0	-0.9	-0.5	-1.0	-0.9	-0.5	-0.7	-1.1
Arm fat-free mass (left)	0.6	2.9	4.8	-2.0	0.2	-0.4	-1.9	-1.7	-1.7	-2.2	-2.0	-2.2	-0.2	-2.0	-1.8
Age started oral contraceptive pill	0.6	0.8	1.8	1.0	0.6	0.5	0.1	1.1	1.0	0.9	1.2	1.3	1.0	0.5	0.8
Unable to work because of sickness or disability	0.6	0.8	4.1	-0.4	-1.3	-0.6	0.2	-0.6	-0.9	-0.7	-0.8	-0.6	-2.0	-0.9	-0.5
Arm predicted mass (left)	0.6	3.3	5.5	-2.2	0.3	-0.5	-1.7	-1.9	-1.9	-2.2	-2.2	-2.3	-0.2	-2.2	-2.0
Schizophrenia vs Biploar Disorder	0.5	0.7	2.6	-0.5	0.7	0.3	-1.6	-0.9	-1.0	-1.1	-0.8	-0.3	-0.0	-0.4	-1.1
Lupus	0.5	0.7	1.8	1.0	0.8	0.6	0.9	0.7	0.9	1.3	0.6	0.9	0.2	0.7	0.8
Blood Platelet Count	0.5	5.2	16.8	-1.9	-4.1	-2.8	-0.5	-1.9	-1.5	-3.1	-2.0	-2.3	-1.9	-1.6	-1.7
Medication for hormone replacement therapy	0.5	0.5	1.4	-0.9	-0.8	0.2	0.4	-0.7	-0.8	-0.6	-0.7	-1.0	-1.2	-0.3	-0.6
Supplements: Zinc	0.5	0.6	1.1	-0.6	-0.8	-0.4	-0.7	-0.6	-0.9	-1.1	-0.7	-0.7	-0.5	-0.8	-0.7
Diabetes (father)	0.5	0.6	3.6	0.4	1.9	1.6	0.2	0.3	0.0	-0.2	-0.1	0.6	0.4	0.1	0.3
Severe depression (siblings)	0.5	0.6	4.3	-0.4	0.1	-0.0	0.6	-0.5	-0.7	-0.3	-0.7	-0.5	-2.1	-0.4	-0.5
Current tobacco smoking	0.5	0.9	1.8	1.0	0.5	-0.4	-0.2	1.3	1.3	0.6	1.2	0.8	0.2	0.9	1.3
Number of incorrect matches in round	0.5	0.9	3.6	-0.7	-1.5	-0.0	-1.0	-0.7	-0.4	-1.9	-0.4	-0.8	-1.2	-0.6	-0.5
Hair/balding pattern: Pattern 2	0.5	0.6	2.1	0.8	0.9	0.6	-0.5	0.9	0.8	0.6	0.7	0.7	1.5	0.3	0.8
Heart attack	0.5	0.6	2.8	0.5	1.7	0.2	0.4	0.9	1.0	0.0	0.8	0.3	0.6	0.7	0.9
Pain all over the body in last month	0.5	0.5	1.4	-0.6	-0.5	-1.0	-0.2	-0.8	-1.1	-0.4	-0.3	-0.5	-1.2	0.1	-0.7
Alcohol intake versus 10 years previously	0.5	0.8	4.8	-0.5	-0.5	1.2	-2.2	-0.6	-1.1	-0.1	-0.4	-0.3	-0.1	-0.4	-0.6
Hair/balding pattern: Pattern 3	0.5	0.7	2.6	-0.9	-1.0	-1.6	0.2	-0.7	-0.9	-0.3	-0.8	-0.7	-0.3	-1.2	-0.7
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.7	-1.2	-1.5	-1.9	1.1	-1.3	-0.8	-0.9	-1.3	-1.6	-0.8	-1.3	-1.2
Mouth/teeth dental problems: Dentures	0.5	0.8	1.7	0.8	1.3	-1.0	-0.0	0.7	0.7	1.0	0.9	0.8	0.9	1.1	0.8
Depression (self-reported)	0.5	0.5	1.5	0.9	0.6	1.2	0.5	0.7	0.6	0.4	0.6	1.1	0.4	0.6	0.7
Prospective memory result	0.5	0.7	1.5	0.4	-0.9	-0.4	-0.9	0.8	0.7	0.2	1.2	0.5	0.8	1.2	0.8
Pulse wave Arterial Stiffness index	0.5	0.6	1.0	-1.0	0.9	-0.8	-0.1	-0.7	-0.4	-0.7	-0.7	-0.8	-1.0	-0.8	-0.7
Trunk predicted mass	0.5	2.9	5.3	-2.0	0.6	0.1	-1.6	-1.7	-1.7	-2.3	-2.1	-2.1	0.0	-2.1	-1.8
Length of working week for main job	0.5	0.6	2.4	0.1	-1.6	-1.5	1.4	0.1	-0.2	0.5	0.0	-0.1	-0.2	-0.2	0.1
Hair/balding pattern: Pattern 4	0.5	1.1	4.6	-0.9	-2.2	-1.3	-0.8	-0.9	-0.7	-0.1	-0.5	-0.8	-1.5	-0.3	-0.9
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.3	0.8	-0.8	0.6	1.2	0.7	0.8	-0.1	0.9	0.7	0.6	0.8	0.8
Gout (self-reported)	0.5	0.7	1.3	1.0	0.8	0.2	0.9	0.9	1.0	1.1	0.5	0.8	1.1	0.3	0.9
Arm fat-free mass (right)	0.5	2.6	5.5	-1.9	0.3	-0.5	-1.9	-1.5	-1.5	-2.4	-1.9	-2.0	-0.1	-1.9	-1.6
Comparative body size at age 10	0.5	1.3	3.9	-1.0	0.3	-1.2	1.8	-0.8	-0.5	-1.0	-0.9	-1.4	-2.0	-0.5	-0.8
Eye problems/disorders: None of the above	0.5	0.6	1.9	0.3	1.4	1.1	-1.1	0.7	0.5	-0.0	0.7	0.4	0.5	0.9	0.5
Medication: Bendroflumethiazide	0.5	0.8	2.0	-0.8	-0.5	-0.9	0.7	-1.0	-0.9	-0.4	-1.1	-0.7	-1.4	-0.8	-0.9
Medication: Atorvastatin	0.5	0.6	3.5	-0.6	0.9	-0.1	0.6	-0.5	-0.4	-1.0	-0.7	-0.7	-1.9	-0.3	-0.4
Fractured/broken bones in last 5 years	0.5	0.6	2.6	-0.5	-0.9	-1.3	0.6	-0.4	-0.9	-1.6	-0.2	-0.7	-0.4	-0.0	-0.2
Commuting to job workplace: Cycle	0.5	0.5	3.6	-0.5	-0.2	-0.5	-1.9	-0.4	-0.6	-0.3	-0.4	-0.6	-0.9	-0.5	-0.3
Basal cell carcinoma (self-reported)	0.5	0.6	3.3	0.8	0.6	1.8	-0.1	0.7	0.4	0.9	0.3	0.8	0.1	0.6	0.5
Crohns Disease (2017)	0.4	0.8	3.1	1.1	1.7	-0.9	-0.0	0.8	1.2	0.5	0.5	0.8	-0.1	0.6	1.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.2	-0.7	-0.3	0.7	1.1	-0.7	-0.8	0.6	-0.6	-0.9	-0.8	-0.3	-0.9
Townsend deprivation index at recruitment	0.4	0.5	3.2	0.1	-0.9	-1.8	0.2	0.4	0.3	-0.8	0.8	0.0	-0.6	0.5	0.3
Taking other prescription medications	0.4	0.6	2.2	-0.5	-0.3	0.7	0.9	-0.7	-1.5	0.5	-0.9	-0.4	-0.6	-1.0	-0.9
Serious illness, injury or assault to yourself	0.4	0.5	0.9	-0.7	-0.8	-0.6	0.9	-0.7	-0.9	-0.9	-0.6	-0.8	0.1	-0.6	-0.8
Hayfever, allergic rhinitis or eczema	0.4	0.9	3.6	-0.6	-1.9	-0.3	0.9	-0.8	-1.2	-1.0	-0.6	-0.9	-0.5	-0.7	-0.7
Chronic bronchitis/emphysema (father)	0.4	0.5	3.5	0.1	1.9	0.8	0.4	0.2	-0.0	1.0	0.0	0.4	0.2	-0.3	0.1
Financial difficulties in last 2 years	0.4	0.6	2.8	-0.5	-1.7	-1.3	-1.1	-0.3	-0.4	0.1	0.1	-0.8	0.2	0.2	-0.2
Noisy workplace	0.4	0.5	1.1	-0.2	-1.0	-0.9	0.8	-0.6	-0.6	-0.7	-0.6	-0.3	-1.1	-0.3	-0.5
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.7	-0.8	-1.1	-0.2	1.3	-1.0	-1.2	-0.1	-1.2	-0.7	-0.7	-1.2	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	2.3	-1.1	-0.7	-1.4	0.6	-1.2	-0.6	-0.8	-1.2	-1.5	-0.9	-1.2	-1.1
Pulse wave reflection index	0.4	0.5	3.2	0.4	1.8	0.9	-0.1	0.5	0.2	0.7	0.2	0.7	0.8	0.1	0.3
Headache pain in last month	0.4	0.7	2.7	0.6	0.7	1.6	0.5	0.8	0.5	0.3	0.7	0.8	1.4	0.4	0.6
Forced vital capacity (FVC), Best measure	0.4	1.4	3.1	-1.3	-0.2	-1.5	0.4	-1.3	-0.9	-0.8	-1.4	-1.8	-1.3	-1.2	-1.3
Number of full brothers	0.4	0.4	1.1	0.8	1.0	-0.4	0.2	0.4	0.5	0.7	0.7	0.9	-0.2	0.8	0.6
Medication: Allopurinol	0.4	0.5	1.0	1.0	0.4	0.8	1.0	0.9	0.8	0.4	0.5	0.8	0.5	0.2	0.8
Age at last live birth	0.4	0.6	1.3	-0.4	-0.9	0.8	-1.1	-0.7	-0.8	-0.4	-0.7	-0.4	-0.9	-0.8	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.9	0.9	0.1	0.8	0.0	0.7	0.8	0.9	0.6	0.8	0.6	1.0	0.7
Commuting to job workplace: Walk	0.4	0.4	2.7	-0.5	-1.6	-0.4	-0.8	-0.5	-0.4	-0.2	-0.2	-0.3	0.6	0.1	-0.5
Medication: Lisinopril	0.4	0.6	2.6	-0.2	0.8	1.6	0.3	-0.4	-1.1	-0.6	-0.3	0.2	1.0	-0.5	-0.5
Alcohol drinker status: Never	0.4	0.5	1.3	-1.1	-0.8	-0.2	0.0	-0.7	-0.8	-0.8	-0.3	-0.9	-0.5	-0.4	-0.8
Heart attack/myocardial infarction (self-reported)	0.4	0.6	2.5	0.4	1.6	0.1	0.3	0.8	1.0	0.2	0.8	0.3	0.6	0.7	0.9
Depression (Nagel 2018)	0.3	0.4	1.0	0.5	-0.3	0.7	0.9	0.6	0.3	0.3	1.0	0.7	0.6	0.9	0.6
Alzheimer’s Disease (in mother)	0.3	0.4	1.2	-0.4	-0.5	-1.1	0.2	-0.5	-0.7	0.3	-0.7	-0.5	-0.2	-0.9	-0.6
Alzheimer’s Disease (including proxy)	0.3	0.4	1.0	0.7	0.7	0.8	0.7	0.6	0.4	1.0	0.5	0.7	0.5	0.0	0.3
Mean Putamen Volume	0.3	0.3	0.9	0.2	-0.6	-0.8	-1.0	0.4	0.4	0.3	0.5	0.2	0.1	0.9	0.5
Schizophrenia (2014)	0.3	0.8	4.6	0.6	2.1	0.4	0.4	0.6	0.6	-0.6	0.9	1.0	0.3	0.8	0.5
Type 2 Diabetes (T2D) (2012)	0.3	0.3	2.2	0.1	1.5	0.2	-1.0	-0.1	-0.4	0.3	-0.1	0.2	0.0	0.4	-0.2
Average weekly spirits intake	0.3	0.3	1.3	-0.2	-0.9	-1.1	0.4	-0.3	0.1	0.1	-0.5	-0.5	-1.1	-0.1	-0.1
Sensitivity / hurt feelings	0.3	0.5	1.7	0.2	1.0	0.6	-1.3	0.5	0.4	-0.0	0.6	0.5	0.9	0.6	0.5
Impedance of leg (right)	0.3	1.4	8.0	-0.1	-2.8	-2.6	0.6	-0.2	0.6	0.8	0.3	-0.2	-0.7	0.2	0.3
Stomach or abdominal pain in last month	0.3	0.4	1.2	0.5	-1.1	-0.6	0.2	0.5	0.7	0.3	0.4	0.3	1.1	0.3	0.7
Impedance of leg (left)	0.3	1.4	6.5	0.2	-2.6	-2.4	0.5	0.2	0.9	1.3	0.7	0.1	-0.5	0.4	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.8	0.5	-1.3	-0.4	0.6	0.6	0.4	-0.0	1.1	0.3	-0.1	1.3	0.4
Forced vital capacity (FVC)	0.3	1.3	3.4	-1.1	-0.8	-1.8	0.8	-1.2	-0.9	-0.6	-1.2	-1.5	-1.0	-1.2	-1.1
Number of live births	0.3	0.5	2.4	-0.2	-1.4	-1.5	0.6	-0.3	-0.1	-0.5	0.1	-0.3	-0.8	0.4	-0.2
Pulse rate	0.3	0.5	1.6	0.8	0.9	0.4	-0.4	0.7	1.3	-0.0	0.6	0.5	0.4	0.8	0.8
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	2.2	-0.5	-1.3	-1.0	-1.5	-0.5	-0.5	-0.6	-0.1	-0.5	-0.6	-0.1	-0.4
Age at first live birth	0.3	0.5	1.3	-0.5	-0.5	0.5	-0.9	-0.6	-1.1	0.1	-0.8	-0.5	-1.1	-0.9	-0.7
Medication: Seretide 50 evohaler	0.3	0.3	1.7	-0.1	1.3	1.2	0.4	0.1	0.0	-0.5	0.4	0.2	0.4	-0.1	0.1
Had major operations	0.3	0.3	0.9	0.4	0.3	0.6	0.8	0.6	0.7	-0.1	0.5	0.3	0.9	0.7	0.7
Family relationship satisfaction	0.3	0.3	1.6	0.1	0.8	1.2	1.2	0.1	-0.3	0.1	-0.2	-0.0	-0.2	0.1	-0.1
Leg pain on walking	0.3	0.4	2.9	0.3	-1.7	-0.9	-0.3	-0.0	-0.4	-0.1	0.2	0.1	-0.2	0.3	0.1
Knee pain experienced in last month	0.3	0.5	2.0	-0.6	-1.4	-0.8	0.6	-0.6	-0.6	-0.3	-0.7	-0.7	-0.1	-0.8	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.0	-0.7	-0.2	-1.0	-0.9	-0.8	-0.7	-0.1	-1.0	-1.0	-0.4	-0.4	-0.6
Average weekly red wine intake	0.3	0.4	1.9	-0.6	-1.4	-0.5	-0.2	-0.7	-0.3	-0.6	-0.5	-0.7	0.1	-0.5	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.4	-0.5	-1.2	-0.0	-0.2	-0.5	-0.4	-0.7	-0.3	-0.5	-1.0	-0.2	-0.5
Osteoporosis (self-reported)	0.3	0.4	1.7	-0.5	-1.3	-1.1	-0.4	-0.4	-0.5	0.6	-0.4	-0.4	-0.0	-0.1	-0.3
Pain experienced in last month	0.3	0.5	1.9	-0.7	-0.5	-1.4	-0.8	-0.6	-0.4	-0.9	-0.4	-0.7	-1.0	-0.3	-0.5
Bipolar Disorder or Schizophrenia	0.2	0.5	2.1	0.7	1.5	0.3	0.7	0.5	0.7	-0.2	0.8	0.9	-0.6	0.5	0.6
Irritable Bowel Disease (IBD)	0.2	0.4	0.9	-0.4	0.0	-0.7	-0.0	-0.6	-0.2	-1.0	-1.0	-0.5	-0.9	-0.9	-0.4
Major Depression (MDD)	0.2	0.3	0.8	-0.4	-0.5	-0.8	-0.9	-0.5	-0.2	-0.9	-0.2	-0.4	-0.6	-0.2	-0.2
Fasting Glucose	0.2	0.3	0.7	0.2	-0.6	-0.9	-0.8	0.1	-0.1	0.7	-0.2	-0.1	-0.5	-0.7	0.1
Neuroticism (2016)	0.2	0.3	1.4	0.5	-0.3	-1.0	-0.3	0.1	-0.2	0.4	0.9	0.4	-0.4	1.2	0.2
Primary Biliary Cirrhosis	0.2	0.4	1.4	0.1	-1.1	-1.2	1.1	-0.0	-0.1	-0.4	0.5	0.1	0.3	0.1	0.2
Lung FVC	0.2	0.9	6.2	0.2	1.1	-0.7	2.5	0.1	0.2	0.4	-0.1	-0.2	-1.4	0.1	-0.0
Number of treatments/medications taken	0.2	0.4	2.3	0.3	0.3	1.0	1.5	0.3	-0.4	0.4	0.2	0.5	0.6	-0.1	0.0
Relative age of first facial hair	0.2	0.4	1.4	-0.5	-1.2	-0.7	0.3	-0.5	-0.5	-0.2	-0.7	-0.7	-0.4	-0.4	-0.4
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.4	0.2	-0.7	1.1	1.2	0.3	-0.1	-0.1	0.3	0.2	-0.1	0.3	0.3
Systolic blood pressure, automated reading	0.2	0.6	1.6	-1.2	-1.1	-0.2	0.0	-0.9	-0.6	-0.7	-0.4	-0.9	-0.5	-1.2	-0.9
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.9	-0.2	0.5	0.9	-0.2	-0.3	-0.9	0.1	-0.4	0.1	-0.7	-0.5	-0.3
Fed-up feelings	0.2	0.4	1.7	0.1	0.7	1.3	-0.4	0.5	0.1	-0.9	0.4	0.2	0.4	0.5	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.9	0.3	-0.4	0.4	0.9	0.3	0.4	-0.3	0.6	0.2	0.3	0.7	0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	1.0	0.1	1.0	1.0	0.1	0.1	-0.1	0.5	0.5	0.3	0.2	0.5	0.1
Alcohol usually taken with meals	0.2	0.4	1.1	-0.4	-0.2	-0.0	-0.1	-0.7	-0.5	-0.9	-0.8	-0.6	0.3	-1.0	-0.6
Allergy	0.2	0.4	1.8	0.1	1.4	-0.1	-0.9	0.2	0.7	1.0	-0.1	0.3	-0.2	0.1	0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.6	0.5	0.6	-0.5	1.3	0.4	0.5	0.4	0.1	0.5	0.6	-0.0	0.4
Father’s age at death	0.2	0.2	0.7	-0.7	0.5	0.9	-0.2	-0.4	-0.3	-0.2	-0.4	-0.3	-0.1	-0.3	-0.6
Worrier / anxious feelings	0.2	0.4	1.2	-0.9	-0.6	-0.1	0.2	-0.6	-1.0	-1.1	-0.0	-0.4	-0.2	-0.1	-0.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.3	-0.1	0.5	0.6	1.1	-0.4	-0.5	0.7	-0.7	-0.1	-0.9	-0.5	-0.5
Medication: Amlodipine	0.2	0.3	1.6	0.0	1.3	0.8	0.5	-0.3	-0.5	0.3	-0.2	0.3	0.6	-0.0	-0.3
Pulse wave peak to peak time	0.2	0.2	1.2	0.6	-1.1	0.4	-0.0	0.3	0.1	0.4	0.3	0.4	0.7	0.3	0.3
Medication: Blood pressure	0.2	0.3	1.4	-0.1	0.9	0.5	1.2	-0.3	-0.3	-0.0	-0.8	-0.0	0.6	-0.6	-0.3
Alcohol intake frequency.	0.2	0.4	1.4	-0.5	-1.2	0.1	-0.9	-0.5	-0.9	-0.5	-0.2	0.0	-0.6	-0.5	-0.7
Loneliness, isolation	0.2	0.3	0.8	0.2	-0.8	0.1	-0.4	0.1	-0.2	-0.9	0.8	0.5	0.7	0.9	0.3
Mineral and other dietary supplements	0.2	0.2	0.6	0.5	0.4	-0.6	-0.8	0.5	0.5	-0.0	0.5	0.4	0.3	0.2	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	1.3	-0.2	0.2	-1.1	0.8	-0.5	0.0	-0.5	-0.4	-0.6	-0.7	-0.4	-0.4
Miserableness	0.2	0.4	2.2	0.1	0.6	1.5	1.0	0.1	0.1	-0.8	0.4	0.2	0.6	0.4	0.0
Wears glasses or contact lenses	0.2	0.2	1.4	-0.2	0.6	-0.4	1.2	0.1	0.1	-0.8	0.5	-0.3	-0.0	0.1	0.0
Mother’s age at death	0.2	0.3	1.2	-0.2	1.1	1.0	-0.9	0.0	-0.1	0.5	-0.1	0.2	0.5	-0.0	-0.2
Financial situation satisfaction	0.2	0.3	2.0	0.3	0.0	0.5	-1.4	-0.2	-0.5	0.6	-0.0	0.1	-0.6	0.1	-0.2
Irritability	0.2	0.3	1.5	0.3	0.2	1.2	0.7	0.3	-0.0	-0.7	0.2	0.5	0.8	0.3	0.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	1.3	-0.3	0.8	1.2	0.2	-0.1	-0.2	-0.2	-0.4	-0.1	0.5	-0.2	-0.1
Supplements: Calcium	0.2	0.2	1.2	-0.5	-0.3	-1.1	-0.1	-0.5	-0.4	-0.1	-0.2	-0.2	-0.1	-0.2	-0.5
Neuroticism (Nagel 2018)	0.1	0.3	1.6	-0.5	-1.3	0.6	0.3	-0.2	-0.7	-0.7	0.3	-0.1	0.3	-0.1	-0.3
Schizophrenia (2018)	0.1	0.3	0.8	0.4	0.7	-0.9	-0.6	0.1	0.3	-0.6	0.7	0.5	-0.2	0.2	0.2
Age at First Birth	0.1	0.2	1.2	0.1	-0.2	-0.3	0.0	-0.0	-0.3	1.1	-0.5	-0.1	-0.3	-0.5	-0.1
Blood Eosinophil Count	0.1	0.9	3.5	0.6	-0.3	0.8	1.4	0.6	0.3	1.7	0.6	1.0	1.9	0.0	0.1
Blood White Count	0.1	0.5	2.4	0.6	-0.9	0.7	1.6	0.6	0.5	0.0	0.4	0.7	0.6	-0.6	0.4
Waist Hip Ratio (WHR)	0.1	0.6	4.6	0.4	1.2	2.2	-0.5	0.1	-0.3	0.5	-0.3	0.7	0.5	-0.2	-0.1
Systolic Blood Pressure	0.1	0.7	4.3	-0.6	-0.4	2.1	0.4	-0.7	-0.5	-0.8	-0.3	-0.2	-0.4	-1.3	-0.8
Allergy or Eczema	0.1	0.4	2.1	-0.1	-1.1	0.1	1.5	-0.3	-1.0	0.2	-0.1	-0.3	-0.3	0.2	-0.4
Neuroticism	0.1	0.2	0.5	-0.5	-0.7	0.1	-0.6	-0.2	-0.6	-0.7	0.0	-0.2	0.4	0.1	-0.4
Hand grip strength (left)	0.1	0.3	1.2	-0.4	0.3	-0.2	-0.9	-0.3	0.3	-0.3	-0.2	-0.5	1.1	-0.2	-0.3
Angina	0.1	0.1	0.3	0.2	0.4	-0.2	-0.4	0.2	0.3	0.0	-0.0	0.1	0.4	0.6	0.3
Hand grip strength (right)	0.1	0.4	2.2	0.2	1.5	0.7	-0.2	0.2	0.9	-0.2	0.2	-0.1	0.9	0.2	0.3
Relative age voice broke	0.1	0.1	0.8	0.0	-0.9	0.4	0.7	-0.2	-0.4	-0.2	-0.0	0.1	0.1	0.2	-0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	-0.1	-0.1	0.5	0.0	-0.0	0.2	0.6	-0.2	-0.0	0.6	-0.5	-0.1
Qualifications: CSEs or equivalent	0.1	0.1	0.4	0.3	-0.2	-0.6	-0.5	0.1	-0.2	-0.3	-0.4	0.4	0.2	-0.4	0.0
High blood pressure	0.1	0.2	1.6	-0.1	-0.3	0.6	1.3	-0.2	-0.4	-0.3	-0.2	0.1	-0.3	-0.5	-0.1
Medication: Atenolol	0.1	0.2	0.4	0.3	0.3	-0.0	-0.4	0.5	0.5	0.4	0.2	0.6	-0.2	0.5	0.6
Illnesses of siblings	0.1	0.2	0.7	-0.3	-0.7	0.4	-0.9	-0.3	0.0	0.2	-0.4	-0.4	0.3	-0.4	-0.4
Neuroticism score	0.1	0.3	1.5	-0.5	-0.4	0.5	-0.2	-0.4	-0.7	-1.2	-0.1	-0.2	0.2	0.1	-0.5
Time employed in main current job	0.1	0.1	0.3	0.1	0.1	-0.1	0.5	-0.1	-0.3	0.2	-0.0	0.2	-0.0	-0.6	-0.3
Tense / ‘highly strung’	0.1	0.1	0.4	0.2	-0.6	-0.1	0.1	0.4	0.1	-0.4	0.5	0.6	0.1	0.5	0.4
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.7	0.0	0.3	-0.1	-0.8	-0.0	-0.0	0.1	-0.2	-0.1	-0.1	0.1	-0.1
Worry too long after embarrassment	0.1	0.2	1.0	-0.2	-0.5	-0.1	0.1	0.2	0.2	-0.2	0.6	-0.0	1.0	0.4	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	-0.0	0.1	0.4	0.6	0.1	0.5	0.2	0.0	-0.2	-0.3	-0.0	0.2
Angina (self-reported)	0.1	0.1	0.3	-0.1	0.2	-0.6	-0.4	-0.0	0.1	-0.2	-0.3	-0.2	0.1	0.3	0.1
Pulse rate, automated reading	0.1	0.3	1.6	-0.3	1.3	0.3	0.1	-0.5	0.0	0.2	-0.5	-0.5	-0.8	-0.5	-0.6
Suffer from ‘nerves’	0.1	0.2	0.5	-0.5	-0.2	0.6	0.3	-0.4	-0.7	-0.6	-0.2	-0.2	-0.4	0.4	-0.5
Overall health rating	0.1	0.3	1.2	0.1	-0.7	0.2	1.1	-0.2	-1.0	-0.5	-0.4	-0.1	-0.4	0.1	-0.4
Hypertension (Self-reported)	0.1	0.3	3.4	0.2	-0.1	0.2	1.8	0.1	-0.0	0.2	0.2	0.3	0.0	-0.2	0.2
Average weekly champagne plus white wine intake	0.1	0.2	0.8	0.2	0.5	0.7	-0.9	0.1	0.3	0.1	-0.3	-0.0	0.1	-0.2	0.1
Guilty feelings	0.1	0.1	0.9	-0.1	-0.4	0.4	-0.9	-0.0	-0.4	-0.3	0.2	0.1	0.4	0.1	-0.1
Medication: Blood pressure	0.1	0.3	1.0	0.2	0.5	0.7	0.9	0.2	-0.1	-0.7	0.4	0.3	-1.0	-0.0	0.2
Diastolic blood pressure, automated reading	0.1	0.4	1.4	0.2	0.8	1.2	-0.1	0.5	0.4	0.7	0.4	0.4	1.0	-0.2	0.3
Myopia	0.1	0.2	1.1	0.0	1.1	0.8	0.2	0.2	-0.0	0.1	0.4	0.3	0.6	-0.1	0.0
Vascular/heart problems diagnosed by doctor	0.1	0.1	1.1	-0.1	-0.2	-0.5	-1.0	-0.1	0.2	0.1	-0.1	-0.2	0.3	0.2	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.5	-0.2	-0.1
Hair Pigment	0.0	0.7	2.8	0.2	-1.1	-1.5	1.7	0.0	-0.0	0.5	-0.2	-0.1	-1.0	0.1	0.2

Hub : Genes

TMEM184B

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Trait associations