Best TWAS P=6.76e-10 · Best GWAS P=1.31e-08 conditioned to 0.486
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PLCD1 | 0.07 | 0.02 | lasso | 4 | 0.03 | 4.2e-04 | 3.5 | 5.5 | 4.2e-08 | 0.73 | 0.03 | 0.92 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | VILL | 0.26 | 0.38 | lasso | 3 | 0.38 | 1.9e-49 | 5.2 | -5.4 | 6.5e-08 | -0.99 | 0.05 | 0.95 | FALSE |
3 | GTEx | Brain Caudate basal ganglia | VILL | 0.35 | 0.38 | lasso | 8 | 0.33 | 3.9e-10 | 5.3 | -5.6 | 2.5e-08 | -0.97 | 0.02 | 0.98 | FALSE |
4 | GTEx | Brain Cortex | VILL | 0.33 | 0.29 | lasso | 2 | 0.25 | 1.8e-07 | 5.5 | -5.6 | 2.0e-08 | -0.89 | 0.02 | 0.98 | FALSE |
5 | GTEx | Brain Frontal Cortex BA9 | VILL | 0.31 | 0.30 | enet | 11 | 0.34 | 7.9e-10 | 5.4 | -5.7 | 1.6e-08 | -0.86 | 0.02 | 0.98 | FALSE |
6 | GTEx | Brain Nucleus accumbens basal ganglia | VILL | 0.31 | 0.13 | lasso | 6 | 0.12 | 5.2e-04 | 5.3 | -6.2 | 6.8e-10 | -0.86 | 0.02 | 0.93 | TRUE |
7 | ROSMAP | Brain Pre-frontal Cortex | VILL | 0.34 | 0.46 | lasso | 3 | 0.46 | 3.1e-65 | 5.2 | -5.3 | 1.3e-07 | -0.96 | 0.06 | 0.94 | FALSE |
8 | ROSMAP | Brain Pre-frontal Cortex | PLCD1 | 0.13 | 0.12 | bslmm | 421 | 0.12 | 6.6e-15 | 5.5 | -5.6 | 2.4e-08 | -0.80 | 0.02 | 0.98 | FALSE |
9 | YFS | Blood | PLCD1 | 0.07 | 0.08 | enet | 15 | 0.08 | 8.0e-25 | 5.5 | 5.6 | 2.5e-08 | 0.85 | 0.02 | 0.98 | FALSE |
10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PLCD1 | 0.01 | 0.02 | blup | 55 | 0.01 | 7.3e-03 | 5.2 | 5.3 | 8.8e-08 | 0.88 | 0.02 | 0.89 | FALSE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | VILL | 0.03 | 0.01 | blup | 52 | 0.01 | 1.5e-02 | 5.4 | -5.3 | 1.1e-07 | -0.73 | 0.01 | 0.67 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PLCD1 | 0.05 | 0.04 | enet | 8 | 0.04 | 6.3e-05 | 5.2 | 5.3 | 1.2e-07 | 0.81 | 0.02 | 0.98 | FALSE |