TWAS hub - TSEN2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1140	0.0420	2.9e-04	0.005	NA	0.024	NA	0.016	1.6e-01	NA	1.7e-02	NA	4.2e-02
2	GTEx	Artery Tibial	0.1397	0.0423	1.2e-05	0.096	NA	0.059	NA	0.068	5.5e-08	NA	2.0e-05	NA	5.3e-06
3	GTEx	Cells EBV-transformed lymphocytes	0.4770	0.0970	8.2e-06	0.267	NA	0.249	NA	0.256	2.7e-09	NA	1.1e-08	NA	6.3e-09
4	GTEx	Cells Transformed fibroblasts	0.3350	0.0540	2.8e-10	0.210	NA	0.229	NA	0.234	1.2e-15	NA	4.2e-17	NA	1.5e-17
5	GTEx	Esophagus Muscularis	0.1200	0.0520	1.9e-03	0.031	NA	0.050	NA	-0.001	5.3e-03	NA	5.6e-04	NA	4.1e-01
6	GTEx	Skin Not Sun Exposed Suprapubic	0.2280	0.0710	5.8e-04	0.102	NA	0.067	NA	0.074	3.3e-06	NA	1.6e-04	NA	6.7e-05
7	METSIM	Adipose	0.0639	0.0247	1.2e-05	0.018	0.027	0.063	0.035	0.053	9.2e-04	5.0e-05	9.3e-10	5.3e-06	2.2e-08
8	NTR	Blood	0.0223	0.0094	1.5e-03	0.000	0.007	0.002	0.007	0.001	2.8e-01	2.0e-03	6.7e-02	1.4e-03	1.8e-01
9	ROSMAP	Brain Pre-frontal Cortex	0.1518	0.0345	1.3e-10	0.111	0.047	0.124	0.096	0.133	4.6e-14	1.0e-06	1.2e-15	2.3e-12	1.0e-16
10	YFS	Blood	0.1445	0.0264	0.0e+00	0.101	0.120	0.143	0.139	0.141	3.1e-31	5.2e-37	2.7e-44	4.3e-43	6.6e-44
11	TCGA	Breast Invasive Carcinoma	0.0329	0.0137	1.7e-05	0.005	0.021	0.018	NA	0.011	2.4e-02	2.5e-05	1.1e-04	NA	2.1e-03
12	TCGA	Cervical Squamous Cell Carcinoma	0.0810	0.0440	7.2e-03	0.018	0.047	0.019	NA	0.034	4.4e-02	2.3e-03	3.8e-02	NA	8.7e-03
13	TCGA	Head and Neck Squamous Cell Carcinoma	0.1087	0.0543	7.6e-04	0.029	0.026	0.034	NA	0.022	2.9e-04	6.0e-04	8.8e-05	NA	1.3e-03
14	TCGA	Lung Adenocarcinoma	0.0418	0.0195	3.2e-03	0.036	0.022	0.037	NA	0.030	4.4e-05	1.2e-03	3.4e-05	NA	1.8e-04
15	TCGA	Lung Squamous Cell Carcinoma	0.0633	0.0293	1.9e-03	0.045	0.022	0.032	NA	0.041	6.4e-06	1.3e-03	1.3e-04	NA	1.7e-05
16	TCGA	Ovarian Serous Cystadenocarcinoma	0.0590	0.0300	6.1e-03	-0.001	0.020	0.027	NA	0.003	4.1e-01	1.5e-02	6.2e-03	NA	1.9e-01
17	TCGA	Prostate Adenocarcinoma	0.0887	0.0349	4.0e-07	0.029	0.061	0.060	NA	0.054	5.0e-04	5.0e-07	6.7e-07	NA	2.4e-06
18	TCGA	Stomach Adenocarcinoma	0.0680	0.0330	3.3e-03	0.062	0.032	0.051	NA	0.050	2.7e-05	2.3e-03	1.4e-04	NA	1.5e-04
19	TCGA	Thyroid Carcinoma	0.0860	0.0340	9.6e-05	0.039	0.051	0.038	NA	0.031	1.1e-04	9.2e-06	1.1e-04	NA	5.2e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Waist Hip Ratio (WHR)	8.2	36.9	121.0	8.4	7.8	5.7	5.5	9.6	4.2	11.0	7.7	3.5	7.6	3.3	7.2	-0.8	-2.0	3.9	5.5	4.4	3.9	0.0
Relative age voice broke	5.1	7.9	14.6	3.8	3.1	3.2	3.2	1.9	3.1	2.5	3.2	1.8	3.6	2.9	2.8	2.2	0.2	3.0	2.6	3.5	2.9	-1.2
High cholesterol (Self-reported)	4.4	7.7	40.3	2.4	4.7	1.4	1.8	4.5	1.4	6.3	3.6	3.1	2.2	1.2	1.9	2.0	-0.5	1.0	2.6	2.3	1.0	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	3.8	4.0	9.1	1.6	1.9	2.1	2.2	1.7	2.1	0.1	1.1	1.8	2.2	2.8	2.1	2.2	1.7	1.9	2.4	3.0	1.9	-1.4
Alcohol intake versus 10 years previously	3.4	5.2	11.6	-2.8	-1.8	-2.5	-2.1	-3.0	-2.0	-1.6	-1.0	-2.3	-2.2	-3.4	-3.0	-1.1	-2.5	-1.8	-2.6	-2.6	-1.8	0.7
Qualifications: nursing, teaching	3.4	5.2	11.0	2.9	2.7	2.7	2.7	1.9	2.5	2.1	1.4	1.9	3.3	2.8	2.7	0.6	-0.0	2.2	2.1	2.5	2.3	-1.2
Fluid intelligence score	2.9	6.1	14.4	2.7	2.5	2.8	2.4	2.4	2.3	1.3	2.1	2.7	3.2	3.8	3.4	0.1	0.7	2.0	2.6	3.6	2.0	-0.2
Pain all over the body in last month	2.8	3.0	9.8	1.2	-0.6	2.5	2.1	1.3	2.4	-0.8	-0.3	-0.4	1.5	1.1	1.2	2.1	1.5	2.6	0.8	1.1	2.6	-3.1
Blood Red Count	2.7	26.5	81.9	-9.1	-6.8	-4.1	-4.3	-7.2	-3.2	-2.8	-8.9	-3.9	-7.3	-4.2	-4.4	-2.1	1.7	-2.9	-5.2	-5.8	-2.8	-0.9
Blood Eosinophil Count	2.6	20.2	57.0	7.5	1.0	5.9	4.5	7.5	4.6	6.9	2.6	-0.0	3.7	2.0	4.0	0.3	3.1	4.8	3.2	3.0	4.8	-5.5
Length of working week for main job	2.6	2.9	9.4	-0.3	-0.6	-1.7	-2.0	-2.3	-1.7	0.4	-0.6	-0.9	-2.5	-1.8	-1.3	-3.1	-0.7	-1.8	-2.2	-2.4	-1.8	0.0
Reason for reducing amount of alcohol drunk: Health precaution	2.6	3.0	4.9	-2.2	-1.6	-2.1	-2.0	-1.7	-2.1	-1.4	-1.2	-1.2	-1.7	-2.0	-1.9	-1.4	-1.0	-2.1	-1.6	-2.0	-2.0	1.0
Ever had bowel cancer screening	2.6	3.1	6.6	-2.6	-2.3	-1.7	-2.0	-1.6	-1.4	-0.1	-2.2	-0.8	-2.4	-2.0	-2.0	-0.7	-0.4	-1.4	-2.4	-2.3	-1.4	-0.7
Lung FVC	2.5	12.9	27.5	-4.2	-2.4	-3.9	-3.7	-5.2	-3.6	-0.2	-1.4	-3.7	-2.8	-4.7	-4.5	-2.9	-4.1	-3.3	-4.4	-4.2	-3.3	0.8
Diabetes (mother)	2.5	3.2	10.9	-0.6	-3.3	2.1	1.1	0.3	1.8	0.6	-0.8	-3.2	0.7	-2.0	-0.0	-0.1	0.0	2.2	-1.5	-1.8	2.2	-3.0
Exposure to tobacco smoke at home	2.4	2.7	5.0	-1.6	-1.2	-1.8	-2.1	-0.9	-2.0	0.2	-2.2	-0.4	-2.0	-1.9	-1.8	-0.7	-0.9	-2.0	-2.0	-2.1	-1.9	1.1
Qualifications: College or University degree	2.3	7.3	15.9	3.5	2.7	3.1	2.7	2.3	2.5	1.6	2.7	3.4	3.0	3.6	4.0	0.0	1.2	2.2	2.8	3.3	2.2	-0.1
Angina (self-reported)	2.2	2.8	6.5	1.7	2.1	1.5	1.7	2.5	1.5	1.8	1.4	2.4	1.0	1.6	1.5	2.0	1.1	1.3	2.2	1.6	1.3	-0.3
LDL Cholesterol	2.1	3.4	19.7	0.8	3.4	-0.4	-0.4	1.9	-0.6	4.4	3.3	0.5	1.5	-1.1	-0.4	-0.9	-3.4	-0.6	0.1	-0.1	-0.8	0.4
Medication: Atenolol	2.1	2.6	5.0	2.1	1.7	2.1	1.8	2.1	1.8	1.4	0.9	1.4	1.6	1.4	2.2	0.3	1.2	1.6	1.6	1.6	1.6	-1.2
Number of children fathered	2.1	2.4	5.1	-1.2	-1.6	-1.2	-1.7	-1.8	-1.5	-1.9	-0.1	-1.7	-1.0	-2.2	-1.5	-1.1	-1.5	-1.4	-2.2	-2.1	-1.4	0.5
Average weekly red wine intake	2.1	3.1	7.3	1.4	1.2	1.7	1.6	2.0	1.6	1.0	0.9	1.9	1.5	2.7	2.3	1.3	2.2	1.3	2.0	2.7	1.3	-1.0
Eye problems/disorders: Glaucoma	2.1	2.5	4.8	1.9	1.4	2.0	2.2	1.1	2.0	0.3	1.2	0.5	2.1	1.6	2.0	0.5	0.6	2.0	1.7	1.8	2.0	-0.9
Type 2 Diabetes (T2D) (2012)	2.0	2.4	5.5	0.8	1.3	1.8	1.6	1.4	1.8	2.4	1.0	1.9	1.0	1.4	2.2	0.5	1.7	1.5	1.4	1.7	1.5	-1.1
Hayfever, allergic rhinitis or eczema	2.0	4.4	9.1	2.8	1.8	2.6	2.4	3.0	2.0	2.0	1.6	1.1	2.6	2.0	2.7	-0.3	1.0	2.0	2.5	2.2	2.0	-0.9
Wheeze or whistling in the chest in last year	2.0	3.6	11.3	2.3	2.4	1.1	1.5	3.4	1.2	1.1	2.4	2.6	2.0	1.9	2.1	1.2	0.3	1.0	2.4	2.6	1.0	0.5
Breast cancer (self-reported)	2.0	2.4	6.2	1.7	0.7	2.1	1.9	2.2	1.7	1.9	0.9	-0.9	2.5	0.5	0.9	1.2	-0.5	1.9	0.9	1.1	1.8	-1.8
Crohns Disease (2012)	1.9	3.0	6.1	-2.5	-1.9	-1.9	-1.9	-1.2	-2.0	-1.3	-1.5	-1.4	-2.2	-1.8	-1.4	-1.9	-0.1	-1.7	-1.6	-2.0	-1.8	1.1
Asthma	1.9	3.8	8.5	2.8	1.7	1.9	2.0	2.7	1.6	1.4	2.3	1.3	2.9	1.9	2.9	-0.1	0.0	1.6	2.1	2.3	1.6	0.5
Eye problems/disorders: Cataract	1.9	2.2	6.1	1.4	2.0	0.3	0.5	2.3	0.2	0.4	1.5	2.5	1.0	2.0	1.1	2.5	0.8	-0.1	1.8	1.1	-0.0	2.1
Asthma (self-reported)	1.9	3.7	8.2	2.8	1.8	1.6	1.8	2.9	1.3	1.6	2.2	1.7	2.7	2.0	2.7	0.3	0.1	1.2	2.2	2.4	1.3	1.0
Angina	1.8	2.3	5.1	1.3	1.8	1.4	1.5	2.3	1.4	1.5	0.9	2.2	0.8	1.4	1.3	2.0	1.2	1.2	2.1	1.6	1.2	-0.4
Chronic bronchitis/emphysema (mother)	1.8	2.0	4.5	2.1	1.0	1.7	1.5	1.7	1.4	-0.0	1.3	1.4	1.5	1.8	1.2	-0.2	1.2	1.4	1.5	1.5	1.4	-1.7
Frequency of depressed mood in last 2 weeks	1.7	2.3	5.0	2.2	1.9	1.5	1.8	1.9	1.6	0.6	1.2	1.2	2.0	1.5	1.8	0.5	0.0	1.5	1.5	1.8	1.5	-0.8
Medication: Simvastatin	1.7	2.6	11.8	-1.0	2.5	-1.8	-1.0	2.7	-1.4	3.4	-0.2	2.4	-1.2	-0.2	0.1	-0.3	0.4	-1.7	1.0	0.4	-1.7	0.9
Father’s age at death	1.7	2.3	8.2	-1.0	0.2	-1.6	-1.6	-2.9	-1.7	-2.1	1.0	-0.4	-0.0	-0.0	-0.8	-1.0	-2.1	-1.8	-1.5	-1.2	-1.8	2.1
Medication: Aspirin	1.7	2.2	6.4	-1.4	-1.2	-1.5	-1.6	-1.3	-1.3	0.8	-1.1	-1.2	-2.1	-2.5	-2.0	-0.8	-0.6	-1.3	-1.7	-2.0	-1.3	-0.7
Intelligence (Savage-Jansen 2018)	1.6	5.0	11.7	2.8	1.5	2.9	2.3	1.1	2.4	1.1	1.8	1.8	2.8	3.4	3.2	-1.1	1.2	2.2	1.6	3.1	2.2	-1.6
Lupus	1.6	2.5	9.2	-0.8	-2.5	1.1	0.6	-1.6	1.1	-2.5	-1.3	-3.0	0.4	-1.6	-0.4	-0.0	-1.0	1.4	-1.9	-1.5	1.4	-2.1
Allergy or Eczema	1.6	4.1	7.7	2.8	1.9	2.4	2.3	2.6	1.9	2.0	2.4	0.9	2.7	1.7	2.3	0.3	0.6	1.9	2.4	2.1	1.9	-1.0
Respiratory disease	1.6	3.5	8.7	2.9	1.6	1.7	1.7	2.5	1.4	1.3	2.0	1.8	2.3	2.1	2.9	-0.2	0.9	1.2	2.2	2.3	1.3	0.6
Hearing difficulty/problems with background noise	1.6	2.5	5.8	2.0	0.5	2.0	1.5	-0.4	1.8	-1.2	1.3	1.4	2.2	2.4	1.7	1.1	1.1	1.7	0.9	2.0	1.7	-1.9
Medication: Cholesterol lowering	1.6	2.6	11.6	1.0	3.2	-0.5	0.1	2.9	-0.4	3.4	1.6	2.6	-0.0	0.7	0.9	0.8	0.1	-0.7	1.7	1.0	-0.7	0.8
Pulse wave peak to peak time	1.6	1.9	7.4	2.1	0.6	0.7	0.7	0.8	0.8	-0.7	-0.5	2.2	0.2	2.7	1.9	-0.4	2.7	0.5	1.5	1.4	0.6	0.7
Comparative height size at age 10	1.6	8.6	38.1	2.8	6.2	0.4	1.4	3.4	0.6	3.1	4.3	4.5	2.8	2.4	2.8	1.3	-2.0	-0.0	2.8	3.5	-0.0	2.8
Crohns Disease (2017)	1.5	3.2	7.0	-2.6	-2.2	-1.8	-1.8	-1.9	-1.7	-0.7	-2.0	-2.5	-1.9	-2.2	-1.7	-0.9	-0.5	-1.4	-1.9	-2.4	-1.4	0.4
Blood Platelet Count	1.5	16.8	112.4	5.4	2.2	4.5	3.5	7.4	3.3	10.6	1.9	1.0	3.8	2.0	3.9	0.7	0.3	3.2	2.5	2.4	3.2	-1.7
Emphysema/chronic bronchitis	1.5	1.7	5.2	-0.6	0.6	-2.0	-1.8	-0.2	-2.1	-0.1	0.9	1.5	-0.9	-0.2	-0.6	-0.7	-0.6	-2.2	-0.5	-0.0	-2.3	2.0
Alcohol intake frequency.	1.5	3.5	10.6	-2.1	0.1	-3.3	-2.3	-1.5	-2.4	-0.2	-1.5	-0.6	-2.6	-1.7	-1.3	-0.8	-0.9	-2.4	-1.2	-1.9	-2.4	2.3
Chronic bronchitis/emphysema (father)	1.4	1.7	3.8	-1.5	-1.7	-1.4	-1.6	-2.0	-1.1	-1.3	-1.7	-0.3	-1.9	-0.5	-1.1	0.0	1.3	-1.1	-1.3	-1.3	-1.1	-0.5
Eye problems/disorders: None of the above	1.4	1.6	5.0	-1.5	-1.3	-1.2	-1.2	-2.2	-1.0	-0.8	-0.8	-1.3	-1.5	-1.7	-1.5	-1.2	-1.2	-1.0	-1.5	-1.1	-1.0	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	3.8	0.8	0.9	1.3	1.7	1.3	1.6	0.1	1.3	0.7	1.7	1.1	1.5	1.2	0.3	1.6	1.6	1.9	1.6	-0.7
Fractured/broken bones in last 5 years	1.4	1.9	9.0	1.1	3.0	0.3	1.2	1.6	0.6	-0.0	1.6	1.7	1.7	1.2	0.9	1.1	-1.0	0.4	1.8	1.9	0.5	0.7
Myopia	1.4	2.1	5.1	-1.6	-1.7	-1.1	-1.6	-2.3	-1.1	-1.7	-1.3	-1.2	-1.7	-0.9	-0.7	-1.8	-0.2	-1.2	-2.0	-1.7	-1.2	0.6
Depression (self-reported)	1.3	1.5	4.7	2.2	0.9	1.3	1.3	1.8	1.3	1.4	0.8	0.5	1.1	1.1	1.6	-0.7	0.7	1.2	1.2	1.4	1.3	-0.6
Standing height	1.3	13.3	40.1	3.6	6.3	1.1	1.6	4.6	1.0	4.0	5.1	6.3	3.1	4.3	4.3	1.2	-0.5	0.2	3.6	4.6	0.2	3.0
Illnesses of father: Heart disease	1.3	1.7	3.3	1.4	1.3	1.1	1.5	1.1	1.5	1.1	1.5	1.3	1.2	1.4	1.8	1.4	0.6	1.3	1.6	1.7	1.3	0.4
Loneliness, isolation	1.3	1.9	5.9	1.3	2.4	0.2	0.4	1.9	-0.1	1.4	1.7	2.3	0.6	1.9	1.4	-0.7	0.7	-0.3	1.8	1.5	-0.3	1.1
Friendships satisfaction	1.3	1.7	5.0	1.7	0.9	1.3	1.2	0.6	1.4	0.8	-0.2	0.8	0.9	1.4	1.9	-2.2	1.5	1.2	0.9	1.3	1.3	-1.4
Alcohol drinker status: Previous	1.3	1.5	4.9	-1.5	0.2	-2.2	-1.5	-0.2	-1.7	-0.2	-1.1	0.6	-1.6	-0.8	-1.0	-0.7	-0.2	-1.9	-0.2	-0.7	-1.8	1.4
Height	1.2	24.0	68.7	5.2	8.3	2.2	2.8	6.0	2.0	5.6	7.3	7.8	4.7	5.5	5.5	2.2	-0.7	1.0	5.0	6.1	1.0	3.2
Qualifications: None of the above	1.2	2.7	6.2	-1.9	-0.1	-2.5	-1.9	-0.7	-2.1	0.1	-0.9	-1.4	-1.4	-2.5	-2.4	-0.3	-1.8	-1.9	-1.3	-1.7	-2.0	0.7
Allergy	1.2	2.7	10.1	-2.5	-1.6	-1.6	-1.5	-3.2	-1.1	-2.0	-1.6	-0.8	-2.2	-1.2	-2.1	0.5	-0.1	-1.1	-1.8	-1.7	-1.1	-0.0
Pulse wave Arterial Stiffness index	1.2	1.4	7.1	-1.8	-0.0	-0.6	-0.5	-0.5	-0.6	1.1	0.9	-1.6	0.0	-2.3	-1.4	0.3	-2.7	-0.4	-1.2	-1.1	-0.4	-0.7
Glaucoma (self-reported)	1.2	1.4	3.3	1.4	0.3	1.7	1.6	-0.2	1.6	-0.7	0.8	-1.0	1.8	0.6	1.0	0.3	-0.0	1.7	0.5	0.8	1.7	-1.7
Depression (Nagel 2018)	1.1	1.7	6.0	1.5	2.3	-0.0	0.7	2.4	0.2	0.8	1.1	1.9	1.2	1.3	1.5	0.4	-0.4	0.0	1.5	1.6	0.1	1.4
Neuroticism	1.1	2.7	13.2	2.6	1.3	1.3	1.4	3.6	1.3	0.4	0.6	1.5	1.1	1.8	1.7	0.2	1.6	1.1	2.1	2.0	1.1	-0.6
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.6	5.0	1.3	2.0	0.7	1.2	1.6	0.7	-0.5	2.2	0.6	2.2	0.9	1.0	0.9	-1.1	0.7	1.5	1.7	0.7	0.5
Happiness	1.1	1.4	4.5	1.9	0.8	1.3	1.1	0.8	1.3	0.2	0.7	0.7	0.8	1.5	2.1	-1.5	1.1	1.2	0.8	0.8	1.2	-0.8
Noisy workplace	1.1	1.4	3.0	-1.4	-0.9	-1.5	-1.2	-1.7	-1.2	-1.6	-0.6	-0.8	-1.5	-1.1	-0.8	-0.1	-0.0	-1.1	-0.9	-1.5	-1.1	1.3
Ever depressed for a whole week	1.1	1.4	7.0	-0.2	-2.6	0.7	-0.0	0.5	0.5	-1.0	-2.2	-0.5	-0.5	-0.1	0.6	-1.1	2.5	0.6	-0.5	-0.4	0.6	-1.7
Verbal and Numeric Reasoning (VNR)	1.0	2.5	5.9	1.5	1.0	2.0	1.6	1.0	1.8	0.9	1.2	1.2	2.2	2.4	2.2	-0.6	0.3	1.6	1.3	2.4	1.6	-0.6
Rheumatoid Arthritis	1.0	1.4	7.6	-1.5	-2.0	1.0	0.4	-0.4	0.4	-1.1	-0.6	-2.8	0.2	-1.6	-0.9	-0.7	-0.7	0.8	-0.8	-1.4	0.8	-1.2
Chronotype (morning person)	1.0	2.3	7.0	-2.0	-0.0	-1.7	-1.3	-2.6	-1.3	-0.7	-1.3	-1.6	-0.7	-1.8	-1.7	-1.8	-1.6	-1.2	-1.9	-1.3	-1.2	-0.9
Relative age of first facial hair	1.0	2.1	6.1	2.5	1.2	1.5	1.1	0.7	1.4	1.8	1.0	2.1	1.0	1.9	1.5	1.6	1.2	1.1	0.9	1.6	1.1	-0.7
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	4.2	-1.2	-1.0	-1.2	-1.1	-0.7	-1.0	0.1	-0.0	-0.9	-1.3	-2.1	-1.4	0.9	-1.2	-0.9	-1.4	-1.1	-0.9	0.2
Qualifications: A levels/AS levels or equivalent	1.0	2.1	5.9	0.7	1.2	1.4	1.6	1.2	1.5	0.3	0.2	2.2	1.3	2.4	2.4	0.0	1.3	1.3	1.8	1.9	1.3	-0.1
Birth weight of first child	1.0	1.9	5.0	-2.2	0.4	-1.8	-1.6	-2.2	-1.5	-1.7	-0.7	-0.4	-1.4	-0.8	-1.1	0.3	-1.1	-1.6	-1.4	-1.1	-1.6	1.0
Mouth/teeth dental problems: Loose teeth	1.0	1.1	5.0	0.1	1.1	-0.3	-0.2	1.8	-0.3	1.0	0.2	2.2	-0.7	1.3	0.7	-0.1	1.9	-0.5	1.3	1.1	-0.5	0.9
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	3.1	1.5	-0.2	1.8	1.4	0.6	1.5	0.3	1.0	-0.4	1.3	0.3	0.5	1.7	0.2	1.6	0.7	0.9	1.6	-1.0
Alcohol drinker status: Never	1.0	1.2	2.9	-0.6	0.9	-1.7	-1.3	-0.7	-1.3	-0.5	0.4	-0.4	-1.1	-1.6	-0.9	-1.2	-1.3	-1.4	-0.8	-1.0	-1.4	0.2
Bipolar Disorder (2018)	0.9	1.4	9.4	-0.1	-2.3	0.0	-0.3	-0.2	0.3	-1.8	-1.8	-0.1	-1.8	0.3	0.2	-0.3	3.1	0.4	-0.4	-0.6	0.3	-1.4
Bipolar Disorder or Schizophrenia	0.9	2.2	9.2	-0.9	-3.0	-0.5	-1.4	0.3	-0.8	-0.8	-2.5	-0.7	-2.7	-1.1	-1.2	-1.4	2.0	-0.7	-1.2	-1.5	-0.7	-1.1
Breast Cancer	0.9	2.2	12.9	-1.1	0.8	-2.4	-1.7	-1.4	-2.0	-0.9	0.3	0.7	-1.0	0.5	-0.7	-0.6	-0.9	-2.1	-0.1	-0.2	-2.1	3.6
HbA1C	0.9	1.0	6.2	-0.6	0.4	-1.2	-0.9	1.2	-1.0	2.5	-1.0	0.4	-1.4	-0.8	-0.5	-0.8	-0.1	-1.0	-0.0	-0.3	-1.1	0.7
Cardiovascular Disease	0.9	3.0	16.9	1.3	2.8	0.3	0.7	3.9	0.2	4.1	2.1	1.7	0.9	-0.2	1.4	-0.1	-1.0	0.0	1.3	1.0	0.0	0.6
Hearing difficulty/problems: Yes	0.9	1.4	6.1	2.5	-0.1	1.6	0.9	-0.8	1.2	-0.3	1.0	0.5	1.4	1.8	1.2	-0.6	0.7	1.2	0.2	0.8	1.2	-1.6
Pulse rate	0.9	1.4	7.2	-1.0	-1.0	-0.6	-0.5	-1.6	-0.5	-0.1	-0.4	-2.0	0.7	-2.0	-1.4	0.6	-2.7	-0.3	-1.7	-1.0	-0.3	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	4.5	1.2	-0.4	1.3	1.2	-0.3	1.4	-1.4	-0.6	-0.5	0.7	0.7	0.7	-0.2	1.2	1.5	0.6	0.9	1.5	-2.1
Prospective memory result	0.9	1.2	3.1	-1.2	-1.6	-0.7	-1.0	-1.1	-0.7	0.4	-0.7	-1.3	-1.2	-1.4	-1.5	0.4	-0.3	-0.6	-1.7	-1.7	-0.5	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.5	1.7	-0.5	1.2	1.0	1.2	1.1	-1.4	1.9	1.2	1.2	0.9	1.2	0.9	1.1	1.0	0.8	1.5	1.1	-0.9
Gout (self-reported)	0.9	1.3	5.2	-0.4	-0.4	-0.1	-0.3	-1.4	-0.3	-1.5	1.2	-1.7	0.6	-1.9	-1.4	-0.2	-2.3	-0.1	-1.4	-1.2	-0.1	-0.4
Pulse rate, automated reading	0.9	2.9	10.0	-2.6	-0.8	-1.8	-1.4	-3.2	-1.4	0.2	-0.8	-1.9	-0.5	-2.4	-1.8	-0.8	-2.6	-1.3	-2.1	-1.6	-1.2	0.5
Family relationship satisfaction	0.9	1.1	3.6	0.6	0.1	0.9	0.9	0.1	1.1	-1.1	-0.2	1.2	0.0	1.0	1.7	-1.5	1.9	1.0	1.0	1.4	1.0	-0.8
Osteoarthritis (self-reported)	0.9	1.2	2.6	-1.6	-0.8	-1.4	-1.2	-0.9	-1.2	0.3	-0.4	-0.5	-1.2	-1.5	-1.6	0.9	-1.2	-1.1	-0.7	-0.8	-1.1	1.3
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.8	-1.2	-1.7	-1.0	-1.0	-0.8	-0.6	1.3	-0.9	-0.9	-1.5	-1.4	-1.3	0.6	0.2	-0.5	-1.4	-1.2	-0.5	-1.0
Medication: Atorvastatin	0.9	1.1	8.0	1.2	1.2	0.5	0.5	0.1	0.6	2.8	1.4	0.0	0.4	-0.8	-0.2	1.4	-1.5	0.5	-0.1	-0.1	0.5	-0.9
Cholesterol lowering medication	0.9	1.3	18.5	-1.0	1.1	-0.5	-0.2	0.9	-0.1	4.3	0.3	0.7	-0.5	-1.1	-0.2	-0.2	-0.7	-0.3	-0.0	-0.3	-0.3	-0.3
Schizophrenia (2018)	0.8	1.8	4.5	-1.1	-2.1	-0.7	-1.5	0.3	-1.3	0.5	-1.7	-0.9	-2.0	-1.7	-1.7	-1.6	0.0	-1.2	-1.3	-1.6	-1.2	-0.3
Alzheimer’s Disease (in father)	0.8	0.9	2.8	0.6	0.6	0.7	1.0	-1.6	1.0	-1.4	0.6	-0.9	1.1	0.3	-0.0	1.2	-0.6	1.0	0.0	0.4	1.1	-1.7
Bipolar Disorder (2011)	0.8	0.8	3.5	0.0	-1.6	0.5	-0.1	-0.3	0.2	-0.8	-1.7	-0.5	-0.9	0.4	0.1	-1.9	1.3	0.4	-0.4	-0.7	0.3	-0.9
Sensitivity / hurt feelings	0.8	1.3	2.9	1.4	0.6	1.4	1.5	0.6	1.7	0.5	1.0	0.5	1.0	0.4	1.1	0.7	0.4	1.6	0.8	1.4	1.6	-1.6
Medication for hormone replacement therapy	0.8	0.9	3.0	-1.1	-0.5	-1.2	-1.0	-0.1	-1.1	0.3	-0.4	-0.5	-0.4	-1.6	-1.2	0.2	-1.7	-0.9	-1.0	-0.5	-1.0	0.6
Maternal smoking around birth	0.8	1.2	4.1	-1.6	-1.3	-0.9	-0.8	-1.1	-0.9	-2.0	-1.7	-0.6	-0.9	-0.7	-1.9	1.0	0.2	-0.7	-0.6	-0.5	-0.7	-0.1
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	4.0	0.8	-0.3	-0.6	-0.8	-0.8	-0.8	0.5	1.1	-1.2	0.2	-1.5	-0.9	-1.6	-2.0	-0.7	-1.2	-1.1	-0.7	0.4
Medication: Ramipril	0.8	1.0	2.3	-0.9	-0.7	-1.2	-1.2	0.4	-1.2	-0.8	-0.8	-0.5	-1.1	-1.1	-0.8	-1.5	-0.5	-1.2	-0.8	-1.5	-1.2	0.9
Neuroticism score	0.8	1.7	6.5	2.5	0.9	1.4	1.3	2.5	1.1	0.1	0.9	0.5	1.2	1.1	1.5	-0.3	0.9	1.1	1.5	1.4	1.1	-0.5
Medication: Lansoprazole	0.8	0.9	3.2	1.1	1.2	1.0	0.9	-0.4	1.0	0.6	1.8	0.2	1.6	0.3	0.4	0.7	-1.4	0.9	0.2	0.5	0.9	-0.9
Breastfed as a baby	0.8	1.0	2.6	0.6	-0.3	1.6	1.4	0.3	1.3	0.4	0.9	0.2	1.3	0.9	0.6	1.4	0.2	1.4	1.0	1.2	1.4	-0.2
Peak expiratory flow (PEF)	0.8	1.9	5.0	1.9	2.2	1.4	1.6	1.0	1.3	0.9	2.0	0.6	2.0	1.3	0.9	1.2	-0.7	1.2	1.4	1.3	1.3	-0.3
Loud music exposure frequency	0.8	0.8	2.2	-1.0	-0.4	-1.5	-0.9	-0.5	-1.0	-0.9	-0.4	-0.5	-1.2	-0.9	-0.7	-1.1	-0.8	-0.9	-0.5	-0.9	-0.9	1.4
Neck or shoulder pain in last month	0.8	1.1	4.6	1.1	2.1	0.3	1.1	0.9	0.7	-0.4	1.8	0.8	1.2	0.6	0.6	1.4	-0.4	0.6	1.4	1.3	0.7	-0.0
Number of full sisters	0.8	1.0	3.3	-0.5	-1.1	-1.2	-1.0	-1.8	-0.6	-1.6	-1.2	-0.1	-1.3	-0.7	-0.6	-1.1	0.4	-0.7	-1.3	-0.5	-0.7	-0.8
Hypertension (Self-reported)	0.8	2.2	9.3	1.5	1.5	1.5	1.6	2.7	1.3	3.0	1.6	0.6	1.6	0.2	1.6	0.3	-0.2	1.3	1.3	1.0	1.3	-0.2
Osteoporosis (self-reported)	0.8	1.0	6.2	-0.5	0.0	-1.3	-0.9	0.1	-0.9	-2.5	-1.8	0.6	-1.3	-0.6	-1.0	0.4	0.4	-0.9	-0.2	-0.5	-1.0	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	7.1	-0.6	-0.2	-0.6	-0.6	-2.7	-0.5	0.1	0.4	-2.1	-0.1	-2.0	-1.3	-1.3	-2.5	-0.4	-1.9	-1.3	-0.4	-0.6
Guilty feelings	0.8	1.2	4.9	2.2	1.1	1.0	0.8	2.0	0.6	-0.2	1.3	0.8	1.1	1.3	1.4	0.2	0.6	0.4	1.2	1.0	0.5	0.1
Medication: Paracetamol	0.8	1.3	8.1	-0.3	-1.0	-0.3	-0.1	-0.5	-0.1	-0.3	-1.4	-2.9	0.4	-1.6	-1.3	0.2	-1.6	0.1	-1.3	-1.6	0.2	-1.3
Illnesses of father: High blood pressure	0.8	1.0	2.7	1.6	0.8	1.1	1.1	1.1	1.0	-1.2	0.6	0.7	0.8	0.7	1.5	0.3	1.1	1.0	1.1	0.8	0.9	-0.6
Average weekly beer plus cider intake	0.8	1.2	8.1	-0.1	0.4	-0.3	-0.1	0.1	-0.3	1.3	1.6	-1.7	1.1	-1.6	-0.7	-0.8	-2.9	-0.1	-1.1	-0.9	-0.1	0.0
Irritability	0.8	1.3	3.8	2.0	0.7	1.6	1.3	1.2	1.2	0.1	0.7	0.1	0.8	1.0	1.1	0.2	1.4	1.3	1.1	1.3	1.3	-1.4
Unable to work because of sickness or disability	0.8	1.0	2.2	-0.9	-1.1	-1.1	-1.3	-0.6	-1.1	0.2	-1.0	-0.8	-1.3	-1.5	-1.4	0.4	-0.6	-1.0	-1.3	-1.2	-1.0	-0.3
Alzheimer’s Disease (in mother)	0.7	0.8	3.4	-1.9	-0.4	-1.2	-1.0	-0.8	-1.0	0.8	-1.4	0.5	-1.1	-0.7	-1.2	0.1	0.2	-1.0	-0.4	-0.3	-1.0	0.3
Alzheimer’s Disease (including proxy)	0.7	1.0	3.9	-1.7	-0.6	-1.1	-0.7	-2.0	-0.6	-0.9	-1.6	-0.5	-0.8	-0.9	-1.3	0.2	-0.1	-0.5	-0.9	-0.8	-0.6	-0.7
Schizophrenia (2014)	0.7	1.5	4.8	-0.8	-2.1	-0.5	-1.3	0.9	-1.0	0.9	-2.1	-0.3	-2.2	-1.1	-1.0	-1.4	1.1	-0.9	-0.9	-1.1	-0.9	-0.5
Triglycerides	0.7	1.2	10.8	-0.1	1.3	-0.1	0.1	2.3	-0.1	3.3	1.2	1.1	0.6	-0.5	0.0	0.4	-0.9	-0.1	0.8	0.4	-0.2	0.3
Smoking Status	0.7	1.6	5.5	-2.3	-1.4	-1.5	-1.2	-1.6	-1.0	-1.6	-1.6	-0.5	-2.0	-0.3	-0.9	-0.5	1.2	-1.0	-0.9	-0.6	-1.0	-0.1
Hand grip strength (left)	0.7	1.9	5.5	0.1	1.1	1.0	0.8	2.4	0.4	1.7	0.4	2.3	0.1	2.0	1.8	-0.6	2.0	0.3	2.0	1.5	0.3	1.0
Ever used hormone-replacement therapy (HRT)	0.7	0.9	5.7	0.5	1.0	0.5	0.6	1.7	0.8	1.4	-0.0	1.0	0.5	0.2	0.2	2.4	0.1	0.6	0.4	1.1	0.6	-1.0
Vitamin and mineral supplements	0.7	1.0	4.7	0.2	2.0	-0.7	-0.5	0.2	-1.1	-0.3	1.5	0.0	0.4	0.2	-0.9	0.4	-1.4	-1.1	0.5	-0.2	-1.1	2.2
Current tobacco smoking	0.7	1.1	4.9	-2.2	-0.6	-1.6	-1.2	-0.9	-1.1	-1.0	-1.1	0.2	-1.5	-0.1	-0.3	-0.7	1.0	-1.2	-0.4	-0.4	-1.2	0.3
Waist circumference	0.7	2.4	10.4	2.7	2.3	0.5	1.0	3.2	0.9	1.2	0.1	2.0	0.6	1.7	1.7	1.8	0.6	0.7	1.5	1.5	0.7	0.8
Nervous feelings	0.7	1.4	4.3	1.3	0.2	1.1	1.2	2.1	1.0	0.9	0.8	1.0	0.4	0.8	1.4	0.7	1.9	1.0	1.8	1.4	1.0	-0.3
Hair/balding pattern: Pattern 2	0.7	0.9	4.6	-1.2	-0.6	-0.6	-0.4	-2.1	-0.2	-1.3	-0.8	-0.8	-0.4	-0.8	-1.0	-0.3	-0.4	-0.1	-1.2	-0.5	-0.1	-1.6
Had menopause	0.7	0.9	2.3	-1.1	0.0	-1.1	-1.0	0.8	-1.0	1.5	-0.8	0.4	-1.2	-0.7	-1.3	1.4	-0.3	-1.1	-0.5	-0.7	-1.1	0.3
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	3.8	-0.5	-2.0	-0.3	-0.7	-0.2	-0.4	-1.2	-1.5	-0.8	-1.0	-0.4	-0.1	-1.0	1.8	-0.2	-0.7	-0.9	-0.2	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.8	0.1	0.6	1.1	0.9	0.1	1.0	0.9	0.1	0.8	0.5	1.3	1.2	-0.5	1.0	0.9	0.8	1.2	0.9	-1.3
Lung cancer (father)	0.7	0.8	2.4	-1.1	0.1	-1.3	-0.5	-0.8	-0.6	-0.4	-0.5	-0.9	-0.4	-1.4	-1.4	1.0	-1.5	-0.5	-0.8	-1.2	-0.5	0.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	7.0	-0.8	-2.7	0.3	-0.4	-2.0	0.0	-1.7	-1.5	-1.1	-0.6	0.1	-0.8	-1.0	0.8	0.2	-1.1	-0.5	0.2	-0.6
Worry too long after embarrassment	0.7	1.2	3.3	1.8	-1.1	1.6	0.8	0.7	1.0	-1.4	-0.0	-0.1	0.5	1.1	1.0	-1.6	1.6	1.0	0.4	0.5	1.1	-1.5
Mean time to correctly identify matches	0.7	1.4	5.2	1.4	0.1	1.2	0.9	0.7	1.3	1.9	0.1	0.0	0.2	0.5	1.8	-0.8	1.7	1.3	0.2	-0.0	1.3	-2.3
Heart disease (mother)	0.7	0.9	2.9	1.1	1.0	0.6	0.8	-0.2	0.8	1.4	0.8	0.9	-0.1	1.0	1.7	-1.0	1.2	0.8	1.0	0.4	0.7	0.8
Chest pain or discomfort	0.7	1.0	4.0	1.1	-0.5	1.2	0.9	0.6	1.1	-0.2	-0.0	1.2	0.2	1.3	1.4	-0.3	2.0	1.0	1.0	0.9	1.1	-0.6
Mood swings	0.7	1.2	5.5	2.3	1.3	0.8	0.9	1.0	0.9	0.2	1.0	1.2	0.9	1.3	1.5	-0.6	0.9	0.7	1.0	1.2	0.7	-0.5
Medication for cholesterol	0.7	1.1	12.0	0.5	-1.0	0.2	0.1	-1.8	0.3	-3.5	-0.9	-0.4	0.3	1.2	0.0	0.8	0.8	0.4	-0.3	0.0	0.4	-0.0
Smoking status: Current	0.7	1.0	4.8	-2.2	-0.6	-1.5	-1.2	-1.2	-1.1	-0.9	-0.7	-0.2	-1.5	-0.5	-0.3	-0.8	0.6	-1.1	-0.7	-0.6	-1.1	0.3
Mother’s age at death	0.7	0.9	4.1	-0.5	1.3	-0.7	-0.4	-2.0	-0.7	-0.6	1.6	0.7	-0.3	0.4	-0.0	-0.2	-0.9	-0.8	0.4	-0.3	-0.8	1.9
Pain type(s) experienced in last month: Hip pain	0.7	0.9	3.0	-1.6	-0.6	-1.0	-0.9	-1.1	-1.1	-1.7	-1.1	-0.4	-0.8	-0.6	-1.4	0.7	-0.0	-1.0	-0.4	-0.5	-0.9	0.2
Supplements: Calcium	0.7	0.7	2.2	-1.2	0.0	-1.2	-0.9	-0.9	-0.8	-0.5	-1.1	1.2	-1.5	-0.5	-0.8	-0.1	-0.1	-0.9	-0.5	-0.3	-0.9	0.2
Basal cell carcinoma (self-reported)	0.7	0.8	2.0	-1.4	-1.0	-1.0	-1.0	-1.3	-0.8	-0.8	-1.2	0.1	-1.4	-0.2	-0.8	-0.1	0.7	-0.9	-0.8	-0.9	-0.8	0.5
Depressed Affect (Nagel 2018)	0.6	1.3	5.1	2.3	1.8	0.4	0.5	2.2	0.3	1.1	0.2	1.6	0.3	1.4	1.4	-0.3	0.9	0.1	1.3	1.2	0.2	0.3
Schizophrenia vs Biploar Disorder	0.6	0.7	2.3	0.7	1.5	-0.1	0.3	1.5	0.0	0.8	0.9	1.4	0.8	0.0	-0.0	0.9	-1.1	-0.2	0.7	1.3	-0.1	0.7
Reaction Time	0.6	1.2	4.3	0.8	0.2	0.9	0.7	1.0	1.1	1.5	-0.3	0.2	0.1	0.6	1.9	-1.7	1.7	1.0	0.1	0.1	1.0	-2.1
Neuroticism (2016)	0.6	0.9	2.7	1.6	1.5	0.2	0.4	0.5	0.6	0.2	0.8	1.3	0.6	1.4	1.4	-0.8	0.9	0.3	1.1	0.9	0.3	-0.1
Blood White Count	0.6	4.3	40.8	-0.3	-0.3	1.8	1.2	2.6	1.4	6.4	-1.3	-2.0	0.0	-0.8	1.0	-1.1	1.2	1.6	0.0	-0.9	1.7	-3.5
Hypothyroidism (self reported)	0.6	1.4	5.4	-0.6	-1.4	0.6	-0.1	1.9	0.3	0.1	-2.2	-0.4	-1.2	-0.2	0.7	-1.8	2.3	0.4	-0.1	-0.4	0.3	-2.1
Hair Pigment	0.6	15.8	29.7	-4.9	-5.0	-4.0	-4.4	-2.7	-4.1	-2.5	-5.3	-3.3	-5.5	-4.3	-4.8	-2.7	0.4	-3.7	-3.8	-4.9	-3.7	1.0
Average weekly spirits intake	0.6	0.7	2.5	-0.4	1.3	-1.1	-0.9	-0.6	-0.9	0.0	0.7	1.3	-0.1	0.3	-0.1	0.7	-0.6	-1.1	-0.3	0.3	-1.1	1.6
Hand grip strength (right)	0.6	1.5	5.2	0.3	1.5	0.6	0.7	1.6	0.3	1.7	1.0	2.3	0.3	1.9	1.6	-0.5	1.0	0.1	1.7	1.5	0.2	1.2
Average weekly fortified wine intake	0.6	0.7	2.4	-0.9	0.0	-0.7	-1.0	0.6	-1.2	1.6	-0.2	1.0	-0.5	-0.2	0.0	-0.1	-0.1	-1.3	-0.2	-0.4	-1.3	1.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	2.5	-0.1	1.3	-0.1	0.4	0.6	0.4	0.4	-0.8	1.6	0.1	1.3	0.7	0.1	1.2	0.2	1.3	1.4	0.2	0.0
Qualifications: CSEs or equivalent	0.6	0.8	1.9	-0.5	-1.0	-0.6	-0.8	-0.8	-0.8	-1.0	-0.2	-1.2	-0.0	-1.2	-0.9	-0.8	-1.1	-0.7	-1.2	-1.4	-0.7	0.4
Sitting height	0.6	4.5	12.8	2.5	3.5	1.2	1.5	2.3	1.3	1.4	2.3	3.6	1.6	3.0	3.1	0.6	0.8	0.9	2.1	2.7	0.9	0.7
Hip circumference	0.6	2.7	17.3	-0.0	-0.2	-1.2	-0.5	-0.4	-0.1	-4.2	-2.9	1.7	-2.0	1.8	-0.1	2.5	2.5	-0.3	0.2	0.7	-0.3	0.7
Hair/balding pattern: Pattern 4	0.6	1.4	2.8	1.1	1.3	1.3	1.5	1.5	1.2	0.4	0.9	0.8	1.4	1.7	1.3	0.9	0.7	1.2	1.6	1.3	1.2	-0.5
Medication: Paracetamol	0.6	1.1	5.7	0.2	-1.2	0.6	0.6	-0.2	0.8	-0.5	-1.1	-2.1	0.8	-0.7	-0.8	0.8	-0.4	1.0	-0.7	-0.6	1.0	-2.4
Medication: Amlodipine	0.6	0.8	5.7	-1.0	0.2	-0.4	-0.2	-0.1	-0.5	0.1	0.7	-1.7	0.8	-1.5	-0.9	-0.6	-2.4	-0.4	-0.9	-0.5	-0.4	0.2
Forced vital capacity (FVC), Best measure	0.6	2.3	11.9	1.4	3.2	0.7	1.0	-0.2	0.7	1.2	3.5	0.8	2.3	0.8	1.3	-0.2	-2.0	0.5	0.6	1.5	0.5	-0.2
Exposure to tobacco smoke outside home	0.6	0.8	2.4	-0.7	-0.2	-0.8	-0.8	0.3	-1.0	1.1	0.1	-0.6	-0.4	-1.2	-1.2	-0.7	-1.6	-1.0	-0.6	-0.7	-1.0	1.2
Medication: Ibuprofen	0.6	0.7	4.2	0.2	-0.6	0.2	0.2	-1.1	0.3	-2.1	-1.2	-1.4	-0.1	-0.3	-0.5	-0.8	0.3	0.4	-0.3	-0.2	0.4	-1.6
Leg pain on walking	0.6	0.8	3.1	-0.6	-1.6	-0.3	-0.7	-0.9	-0.6	-0.4	-0.0	-1.8	-0.4	-1.1	-1.0	-0.5	-0.5	-0.3	-1.2	-1.1	-0.3	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	4.5	0.4	2.1	-0.4	-0.4	1.2	-0.8	1.8	1.9	0.8	0.7	0.0	0.7	-1.3	-1.5	-0.9	0.4	0.4	-0.9	1.4
Mineral and other dietary supplements	0.6	0.8	2.1	1.2	1.3	1.0	0.8	0.7	0.5	0.3	1.2	0.3	1.4	1.3	1.2	-1.1	-0.2	0.5	0.9	0.8	0.5	0.7
Medication: Aspirin	0.6	0.8	3.0	-0.5	-0.3	-0.8	-0.8	-0.6	-0.7	1.2	0.1	-0.8	-1.2	-1.7	-1.2	-0.7	-0.7	-0.7	-1.0	-1.2	-0.7	-0.8
Illnesses of father: None of the above (group 1)	0.6	0.7	3.9	-0.8	0.4	-0.8	-0.5	-0.7	-0.9	-0.1	0.5	-0.8	-0.3	-0.9	-1.5	0.1	-2.0	-0.7	-0.2	-0.2	-0.7	0.9
Commuting to job workplace: Cycle	0.6	0.8	3.8	0.3	-1.2	1.0	0.7	0.2	0.9	-0.0	-0.7	0.8	-0.5	0.8	0.7	-0.7	1.9	1.0	0.6	0.5	1.0	-1.1
Neuroticism (Nagel 2018)	0.5	1.1	6.1	2.0	1.0	0.7	0.8	2.5	0.4	0.2	0.2	1.0	0.4	0.9	1.0	-0.2	1.1	0.4	1.5	1.4	0.4	-0.3
Major Depression (MDD)	0.5	0.6	1.9	-0.5	0.4	-1.4	-1.0	-0.1	-1.0	0.3	-0.2	0.8	-1.4	-0.2	-0.6	0.4	0.5	-1.2	-0.1	0.1	-1.2	0.4
Prostate Cancer	0.5	0.7	8.2	0.9	-0.5	-0.3	-0.3	0.3	-0.5	-2.9	1.2	0.6	0.1	0.4	-0.1	0.5	0.6	-0.5	0.5	0.3	-0.4	0.7
Mean Putamen Volume	0.5	0.6	2.0	1.4	-0.3	0.8	0.6	0.6	1.0	0.0	-0.1	0.4	0.7	1.1	0.6	0.8	1.0	0.9	0.2	0.7	0.9	-1.1
Heel T-Score	0.5	3.7	21.4	-1.7	-1.8	0.2	-0.4	-3.0	-0.1	-4.6	-1.4	-1.6	-1.2	-0.3	-0.2	-3.7	1.9	0.1	-0.6	-1.7	0.1	-2.4
Number of treatments/medications taken	0.5	1.0	4.3	-0.8	-0.4	-1.0	-0.8	-0.2	-0.8	0.8	-0.1	-1.5	-0.8	-2.1	-1.0	-0.3	-1.3	-0.8	-1.1	-1.4	-0.8	-0.6
Ever had hysterectomy (womb removed)	0.5	0.5	2.5	0.6	-0.1	0.4	0.3	1.6	0.4	1.4	0.9	-0.4	0.3	-1.0	0.0	0.2	-1.1	0.4	-0.6	-0.4	0.4	-0.7
Supplements: Zinc	0.5	0.6	1.8	0.1	-1.3	0.4	0.5	0.1	0.8	-1.2	-0.4	0.8	-0.2	0.2	0.3	1.0	1.2	0.9	0.1	0.6	0.8	-1.3
Trunk fat percentage	0.5	1.8	6.7	1.3	0.5	-1.2	-1.1	-0.5	-0.8	-2.6	-2.4	1.5	-1.6	1.8	-0.1	1.6	1.4	-1.0	-0.3	-0.0	-1.0	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.0	1.1	0.9	0.3	0.7	0.8	0.6	0.5	1.4	0.7	1.3	0.9	0.6	1.3	-0.7	0.5	0.6	0.8	0.5	0.6
Taking other prescription medications	0.5	0.8	2.1	-0.6	-0.8	-1.1	-1.1	0.1	-1.2	0.6	-0.2	-0.7	-1.0	-1.4	-0.6	-0.6	-0.6	-1.1	-0.9	-1.2	-1.1	0.3
Serious illness, injury or assault to yourself	0.5	0.6	2.4	-1.5	-0.6	-0.5	-0.5	-0.5	-0.5	-0.1	-1.1	-0.4	-0.7	-1.0	-1.2	-0.9	-0.5	-0.5	-0.6	-0.7	-0.4	-0.6
High blood pressure	0.5	1.5	7.6	1.0	1.6	1.1	1.1	2.3	0.8	2.8	1.5	0.7	1.3	-0.0	1.4	-0.1	-0.4	0.8	1.0	0.7	0.8	-0.0
Medication: Levothyroxine sodium	0.5	0.8	4.2	-0.2	-0.9	0.1	-0.2	1.5	0.1	0.1	-2.0	-0.1	-0.9	0.2	0.4	-0.3	2.0	0.1	-0.2	-0.3	0.1	-1.6
Financial difficulties in last 2 years	0.5	0.6	2.3	-0.2	0.7	-1.4	-0.9	-1.1	-0.8	-1.1	0.1	0.2	-0.8	0.1	0.0	-1.5	-0.2	-1.0	-0.7	-0.2	-1.0	0.0
Diabetes (self-reported)	0.5	0.8	3.9	-1.0	0.9	-0.8	-0.6	1.5	-0.9	2.0	-0.2	-0.3	-0.3	-0.9	-0.2	-0.9	-0.8	-0.9	0.1	-0.4	-0.9	0.6
Weight	0.5	2.5	10.8	1.6	2.9	-0.6	0.1	2.4	-0.1	0.0	-0.0	3.3	-0.3	2.4	1.1	2.0	1.0	-0.4	1.5	1.6	-0.4	1.8
Trunk fat-free mass	0.5	2.9	11.2	0.6	3.4	-0.3	0.5	3.3	0.1	2.4	1.9	3.0	0.7	1.4	1.4	0.7	-0.3	-0.2	1.9	1.6	-0.2	1.8
Trunk predicted mass	0.5	3.0	11.6	0.8	3.3	-0.2	0.6	3.4	0.3	2.3	2.0	3.1	0.8	1.5	1.5	0.7	-0.2	-0.1	2.0	1.7	-0.1	1.7
Pulse wave reflection index	0.5	0.6	2.2	-1.2	0.2	-0.6	-0.5	0.3	-0.4	0.7	-0.8	-0.8	-0.9	-1.5	-0.5	-0.6	-0.7	-0.3	-0.7	-1.1	-0.3	-0.5
Body fat percentage	0.5	1.9	8.3	1.0	-0.0	-1.2	-1.1	-0.9	-0.7	-2.9	-2.9	1.1	-1.9	1.6	-0.3	1.4	1.7	-0.9	-0.5	-0.3	-0.9	0.9
Leg fat percentage (right)	0.5	1.7	8.3	0.7	-0.5	-1.3	-0.9	-1.3	-0.6	-2.6	-2.9	0.7	-2.1	1.1	-0.6	1.1	1.7	-0.7	-0.4	-0.4	-0.7	0.9
Medication: Allopurinol	0.5	0.7	2.7	-0.2	-0.7	0.4	0.0	-0.7	0.1	-1.1	0.7	-1.0	0.7	-1.6	-0.9	-0.1	-1.4	0.2	-1.0	-0.8	0.2	-1.2
Knee pain experienced in last month	0.5	0.7	1.7	0.5	-0.5	0.9	0.8	1.1	0.8	-1.2	0.6	-1.0	1.3	-0.5	-0.4	1.2	-0.7	1.0	0.1	-0.4	1.0	-0.9
Wears glasses or contact lenses	0.5	0.6	1.6	-0.4	-0.6	-0.8	-0.9	-0.6	-0.7	0.7	-0.8	0.1	-0.6	-0.4	-0.6	1.3	-0.5	-0.8	-1.1	-0.6	-0.8	1.1
Commuting to job workplace: Public transport	0.5	0.6	1.8	0.2	1.3	0.8	0.8	0.8	0.5	-0.0	0.7	0.9	0.9	0.8	0.6	0.0	0.1	0.5	1.3	1.2	0.5	-0.2
Leg fat percentage (left)	0.5	1.7	8.9	0.4	-0.5	-1.4	-1.0	-1.1	-0.7	-2.6	-3.0	0.7	-2.2	0.9	-0.7	0.9	1.6	-0.8	-0.4	-0.5	-0.8	0.6
Arm fat-free mass (left)	0.5	2.3	9.7	0.5	3.1	-0.5	0.5	3.1	0.1	1.8	0.8	2.8	0.3	1.3	1.1	1.2	0.2	-0.2	1.8	1.5	-0.2	1.4
Heart disease (siblings)	0.5	0.6	2.9	-0.2	0.5	-0.9	-0.6	0.6	-0.8	1.7	-0.6	0.4	-0.9	-0.6	-1.3	0.5	-0.4	-0.8	-0.0	-0.2	-0.8	0.3
Ovarian Cancer	0.4	0.5	2.5	0.1	0.2	-0.4	-0.5	0.7	-0.6	0.2	-0.3	1.0	-0.9	0.8	-0.1	1.1	1.6	-0.7	0.5	0.4	-0.7	0.4
Body Mass Index (BMI) (2010)	0.4	0.5	2.2	0.5	0.4	-0.5	-0.1	0.5	-0.1	0.4	-0.4	1.5	-0.7	0.9	0.0	1.3	1.3	-0.2	0.9	0.6	-0.2	0.6
Coronary Artery Disease (CAD)	0.4	0.5	3.6	0.6	1.4	-0.0	-0.0	-0.8	0.3	1.9	1.2	0.2	-0.0	-0.2	0.6	-0.7	-0.0	0.2	-0.1	-0.1	0.0	-0.8
Primary Biliary Cirrhosis	0.4	0.6	2.8	0.3	-1.3	0.1	-0.1	0.1	-0.1	-0.2	0.2	-1.7	0.1	-1.1	-1.0	0.5	-1.1	0.2	-1.0	-1.2	0.2	0.0
Lung FEV1/FVC ratio	0.4	2.3	6.6	-0.5	-0.7	-1.1	-1.1	-1.8	-0.9	0.7	-0.2	-2.3	-1.0	-2.6	-2.2	0.6	-2.5	-0.8	-2.0	-2.4	-0.7	0.0
Medication: Co-codamol	0.4	0.4	3.0	-0.1	-1.0	-0.7	-0.5	0.1	-0.4	-1.3	-0.7	0.2	-0.4	-0.1	-0.6	1.7	0.0	-0.4	-0.5	-0.2	-0.4	0.4
Medication: Metformin	0.4	0.5	1.5	-0.5	-0.6	-0.2	-0.3	0.9	-0.1	1.2	-1.0	-0.9	-0.7	-0.9	0.1	-1.1	0.7	0.0	-0.5	-0.9	-0.0	-0.7
Pack years adult smoking proportion	0.4	0.6	2.9	0.4	1.1	-1.1	-0.7	0.1	-1.0	-0.2	1.0	0.5	-0.6	-0.2	-0.2	-1.7	-0.5	-1.0	-0.2	-0.5	-1.0	0.3
Leg fat-free mass (left)	0.4	2.0	8.7	0.5	2.9	-0.8	-0.1	2.5	-0.5	0.7	0.6	2.7	-0.1	1.7	0.9	1.1	0.0	-0.8	1.3	1.1	-0.8	2.3
Townsend deprivation index at recruitment	0.4	0.6	1.8	-0.9	0.1	-1.1	-0.7	-0.5	-0.9	-0.9	-1.4	-0.4	-1.3	-0.2	-0.6	-0.4	0.3	-0.8	-0.3	-1.0	-0.8	-0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.8	-0.0	-0.7	0.1	0.1	-0.1	0.3	1.3	0.7	-0.0	0.5	-1.1	-0.4	1.3	-1.3	0.4	-0.9	-0.2	0.3	-0.2
Leg predicted mass (left)	0.4	1.9	8.5	0.4	2.9	-0.8	-0.2	2.4	-0.5	0.7	0.7	2.6	-0.1	1.6	0.8	1.1	-0.1	-0.8	1.3	1.1	-0.8	2.3
Trunk fat mass	0.4	1.7	4.3	1.5	1.4	-1.0	-0.7	0.4	-0.6	-1.8	-1.6	2.0	-1.2	2.1	0.4	1.7	1.2	-0.9	0.3	0.4	-0.9	1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	6.5	-0.5	-0.8	0.5	0.1	-1.3	0.3	-2.5	-1.1	-0.4	-0.8	0.4	0.7	-1.3	1.7	0.3	-0.1	-0.7	0.4	-1.1
Mouth/teeth dental problems	0.4	0.7	3.1	-1.3	-0.6	-0.7	-0.6	-1.8	-0.4	-0.9	-1.3	-0.7	-0.6	-0.9	-0.7	-0.4	-0.6	-0.4	-0.9	-0.4	-0.4	-0.1
Arm fat percentage (right)	0.4	1.6	6.3	1.3	0.5	-0.7	-0.6	-0.1	-0.4	-2.5	-2.3	1.4	-1.5	2.0	0.2	1.3	1.9	-0.6	0.2	0.1	-0.6	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.6	1.6	1.3	0.4	0.4	1.2	0.1	-0.3	1.3	0.4	1.3	0.2	0.5	0.8	-1.6	0.1	0.2	0.9	0.1	0.4
Number of live births	0.4	0.6	2.3	0.5	1.5	-0.6	-0.2	0.8	-0.4	-0.3	0.8	1.5	-0.0	1.1	0.3	-0.6	0.6	-0.6	0.9	0.7	-0.6	0.7
Illnesses of mother	0.4	0.5	1.9	-0.4	0.3	-0.3	-0.3	-0.6	-0.4	-1.1	0.6	-0.1	0.6	0.4	-0.8	1.4	-1.2	-0.5	-0.2	1.0	-0.5	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	7.5	0.7	2.6	0.1	0.4	-0.9	0.0	1.0	2.7	-0.1	1.5	-0.2	0.3	-0.2	-2.7	-0.0	-0.1	0.3	-0.0	0.3
Arm fat mass (right)	0.4	1.5	4.2	1.3	1.6	-0.6	-0.2	1.2	-0.2	-1.3	-1.4	2.0	-0.9	2.0	0.6	1.7	1.4	-0.4	0.8	0.7	-0.4	1.4
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.6	0.9	-0.1	0.3	0.5	1.6	0.5	-0.8	0.4	-0.1	0.5	0.3	0.8	-0.5	1.2	0.5	0.9	0.7	0.5	-0.5
Headache pain in last month	0.4	0.7	2.8	1.7	1.0	0.4	0.7	0.6	0.6	-1.1	0.8	0.7	0.6	0.3	0.5	0.8	0.3	0.6	0.6	1.2	0.6	-1.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	4.1	-0.8	-0.9	-0.2	-0.5	1.2	-0.3	-0.7	-1.9	0.1	-1.3	0.0	-0.0	-0.6	2.0	-0.3	-0.2	-0.4	-0.3	-1.4
Medication: Ventolin 100micrograms inhaler	0.4	0.6	3.3	1.1	0.6	0.4	0.6	1.8	0.2	-0.0	0.6	0.7	0.8	0.7	0.8	0.2	0.6	0.2	1.1	0.9	0.3	0.1
Arm fat-free mass (right)	0.4	2.3	9.9	-0.0	3.1	-0.8	0.3	3.0	-0.1	2.1	0.8	2.6	0.2	1.0	0.8	1.3	-0.3	-0.4	1.7	1.4	-0.4	1.7
Comparative body size at age 10	0.4	1.0	3.4	-1.3	-0.4	-0.8	-0.4	-1.3	-0.4	-1.9	-1.2	0.9	-1.4	1.2	-0.1	1.0	1.2	-0.4	0.3	0.5	-0.4	1.5
Number of full brothers	0.4	0.5	4.1	-0.2	0.5	-0.3	0.2	-0.9	0.3	-2.0	-1.1	0.6	-0.0	1.0	0.1	-0.7	0.5	0.1	0.3	0.1	0.2	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	2.3	1.4	0.9	0.3	0.1	1.3	-0.1	0.3	1.5	0.4	1.0	0.2	0.4	-0.3	-1.1	-0.2	0.1	0.4	-0.2	0.3
Age at first live birth	0.4	0.7	3.7	-0.6	-0.3	0.2	-0.2	-1.9	-0.2	-0.2	0.5	-1.5	0.7	-0.6	-0.1	-1.7	-1.4	-0.1	-0.8	-0.8	-0.1	0.2
Health satisfaction	0.4	0.5	2.7	0.4	-1.1	0.4	0.1	-0.0	0.3	-0.6	0.1	-1.7	-0.1	-0.4	0.5	-1.6	0.4	0.4	-0.7	-0.5	0.4	-0.9
Medication for pain relief, constipation, heartburn	0.4	0.8	2.5	0.5	1.3	0.3	0.4	0.7	0.1	0.3	1.0	1.5	0.6	1.5	1.1	0.3	0.4	0.0	1.1	0.9	0.0	1.6
Medication: Blood pressure	0.4	0.7	2.9	1.2	1.7	0.3	0.7	1.4	0.4	0.2	1.4	-0.1	1.3	-0.2	0.8	0.3	-0.8	0.4	0.6	0.4	0.4	0.1
Migraine (self-reported)	0.4	0.5	4.6	-0.2	-1.0	-0.2	-0.2	-0.4	-0.0	0.3	-0.9	1.0	-1.0	1.1	0.1	0.2	2.1	-0.1	0.3	0.3	-0.1	-0.0
Whole body fat mass	0.4	1.6	4.3	1.1	1.3	-1.2	-0.7	0.4	-0.6	-1.8	-1.8	2.1	-1.4	1.9	0.2	1.6	1.3	-0.9	0.4	0.4	-0.9	1.7
Leg fat mass (right)	0.4	1.6	5.7	0.7	0.7	-1.6	-1.1	-0.1	-0.9	-2.0	-2.4	1.5	-1.9	1.4	-0.2	1.0	1.2	-1.1	0.0	-0.1	-1.1	1.8
Arm predicted mass (right)	0.4	2.1	8.8	0.1	2.8	-0.6	0.5	3.0	0.2	1.9	0.7	2.6	0.3	1.1	1.0	1.3	-0.0	-0.1	1.7	1.4	-0.1	1.6
Suffer from ‘nerves’	0.4	0.6	2.8	1.7	0.5	0.1	0.1	1.6	0.2	0.5	1.1	1.1	0.7	0.3	0.5	-0.9	0.3	0.0	0.4	0.9	0.0	-0.6
Had major operations	0.4	0.4	1.5	-0.6	-0.8	0.0	-0.1	0.2	-0.0	0.4	-1.2	-1.0	-0.9	-0.9	-1.0	-0.8	-0.1	0.1	-0.2	-0.7	0.1	-0.8
Age at last live birth	0.4	0.6	7.0	-0.2	-0.1	0.0	0.1	-1.5	0.2	-2.6	0.3	0.2	0.4	0.3	0.2	-1.0	0.4	0.2	0.1	0.1	0.2	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.8	-0.2	-1.5	0.4	0.3	-0.1	0.5	-1.2	-0.6	-0.2	-0.6	-0.1	0.4	-0.1	1.7	0.6	0.1	0.1	0.6	-0.2
Supplements: Vitamin C	0.4	0.5	2.7	-0.4	-1.4	0.3	0.3	-0.2	0.6	-0.4	-1.0	0.7	-0.5	0.5	0.2	0.4	1.6	0.7	0.2	0.7	0.6	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	2.1	1.2	1.0	0.3	0.4	0.1	0.5	-0.3	1.5	0.6	0.6	0.2	0.3	0.6	-1.3	0.4	-0.3	0.4	0.4	-0.2
Whole body fat-free mass	0.4	2.4	10.2	0.4	3.2	-0.6	0.2	3.1	-0.2	1.8	1.3	2.8	0.3	1.4	1.1	0.9	-0.2	-0.5	1.6	1.3	-0.5	1.9
Leg fat-free mass (right)	0.4	2.2	9.8	0.1	3.1	-1.0	-0.2	2.7	-0.6	1.0	0.8	2.6	-0.1	1.5	0.6	1.1	-0.3	-1.0	1.3	1.1	-0.9	2.4
Arm fat percentage (left)	0.4	1.6	6.2	1.0	0.5	-0.7	-0.6	0.1	-0.4	-2.5	-2.4	1.4	-1.5	2.0	0.2	1.5	2.0	-0.5	0.2	0.1	-0.5	1.1
Whole body water mass	0.4	2.4	10.1	0.3	3.2	-0.6	0.2	3.0	-0.2	1.8	1.0	2.9	0.2	1.4	1.0	1.0	-0.1	-0.5	1.6	1.3	-0.5	1.9
Leg predicted mass (right)	0.4	2.1	9.6	0.2	3.1	-0.9	-0.2	2.7	-0.6	1.0	0.8	2.6	-0.0	1.5	0.7	1.1	-0.3	-0.9	1.4	1.1	-0.9	2.3
Ever taken oral contraceptive pill	0.4	0.4	2.2	-0.5	0.1	-0.7	-0.5	-1.0	-0.6	-1.5	-0.3	0.0	-0.4	0.5	-0.4	-1.0	-0.3	-0.6	-0.4	-0.1	-0.6	0.5
Hearing aid user	0.4	0.5	1.7	0.1	0.3	-0.7	-0.6	-0.2	-0.3	1.3	-1.1	0.8	-0.3	-0.4	-0.5	-0.1	-1.2	-0.6	-1.0	-0.5	-0.5	-0.4
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.8	-0.5	-0.3	-0.5	-0.7	-0.6	-0.7	0.5	-1.0	-0.2	-0.5	-0.3	-1.1	-1.3	-0.2	-0.7	-0.4	-0.6	-0.7	0.1
Medication: Lisinopril	0.4	0.5	2.4	-0.4	0.2	-0.3	-0.6	1.2	-0.5	1.6	-1.0	1.3	-0.9	-0.3	0.1	-0.3	0.8	-0.7	0.0	0.2	-0.7	-0.2
Basal metabolic rate	0.4	2.3	9.6	0.6	3.1	-0.8	0.1	2.8	-0.3	1.3	0.7	3.0	0.0	1.6	1.0	1.1	0.1	-0.6	1.5	1.4	-0.6	2.1
Number of operations (self-reported)	0.4	0.5	1.5	-1.1	-0.9	-0.1	-0.2	0.3	-0.0	0.1	-1.1	-0.8	-0.8	-1.1	-1.2	0.6	-0.1	0.0	-0.6	-0.9	0.0	-1.2
Ever had prostate specific antigen (PSA) test	0.4	0.4	3.3	0.1	-0.2	0.6	0.2	-0.4	0.4	-1.8	0.1	0.7	-0.2	0.6	0.8	-0.3	1.2	0.3	0.4	0.3	0.3	-0.7
Age started oral contraceptive pill	0.4	0.5	2.5	-0.3	0.1	-0.0	-0.2	-0.3	0.1	0.8	0.0	-1.2	0.3	-0.7	-1.1	0.9	-1.6	0.0	-1.0	-0.6	0.0	-0.9
Vascular/heart problems diagnosed by doctor	0.4	1.1	6.7	-0.8	-1.3	-0.8	-0.7	-2.2	-0.5	-2.6	-1.2	-0.6	-0.6	0.2	-1.2	0.5	0.2	-0.4	-0.9	-0.4	-0.4	-0.1
Pain experienced in last month	0.4	0.7	3.2	-0.4	0.0	-0.4	-0.9	-0.8	-0.5	1.8	-0.8	1.3	-1.0	0.3	0.7	-0.7	0.8	-0.8	-0.6	-0.2	-0.8	0.7
Pack years of smoking	0.4	0.6	2.0	0.6	1.3	-1.0	-0.7	0.2	-1.0	-0.0	1.4	0.7	-0.6	-0.1	-0.3	-1.4	-0.5	-1.1	-0.2	-0.4	-1.1	0.2
Leg fat mass (left)	0.4	1.6	5.6	0.6	0.8	-1.6	-1.0	0.0	-1.0	-2.0	-2.4	1.5	-1.9	1.3	-0.3	1.0	1.1	-1.1	0.1	-0.1	-1.1	1.6
Arm predicted mass (left)	0.4	2.2	9.2	0.4	3.0	-0.4	0.6	3.0	0.3	1.6	0.5	2.8	0.3	1.4	1.2	1.2	0.2	-0.0	1.9	1.6	-0.0	1.4
Worry (Nagel 2018)	0.3	0.5	7.6	0.6	-0.1	0.2	0.3	2.8	-0.2	0.5	0.2	0.0	0.2	-0.4	0.1	-0.2	0.3	-0.1	1.0	0.5	-0.0	0.3
Irritable Bowel Disease (IBD)	0.3	0.7	2.7	-1.6	-0.7	-0.8	-0.8	-0.8	-0.9	0.5	-0.6	-0.9	-1.0	-1.2	-0.7	-0.3	-0.5	-0.7	-0.8	-0.8	-0.7	0.7
Age at First Birth	0.3	0.5	2.1	-0.6	-1.0	-0.0	-0.5	-0.1	-0.6	1.5	-0.6	-0.5	-0.3	-0.9	-0.6	-0.7	-1.0	-0.6	-0.8	-0.7	-0.5	0.3
Fasting Glucose	0.3	0.4	1.2	0.6	0.5	0.3	0.5	0.7	0.3	-0.9	1.1	0.8	0.5	0.3	0.4	1.0	-0.1	0.3	0.5	0.7	0.3	0.5
BMI	0.3	1.9	11.8	0.5	0.9	-1.0	-0.4	0.4	-0.1	-3.4	-2.7	1.6	-1.8	1.5	0.1	1.6	2.1	-0.3	0.3	0.1	-0.3	0.2
Systolic Blood Pressure	0.3	1.3	4.5	-1.1	1.0	-1.2	-0.4	1.6	-0.9	1.7	1.1	-0.9	-0.0	-2.1	-1.0	0.6	-1.6	-0.8	0.4	-0.8	-0.8	1.3
Type 2 Diabetes (T2D) (2018)	0.3	0.5	3.2	-1.1	0.8	0.2	0.4	1.6	0.3	1.8	-0.4	-0.2	0.2	-0.3	0.9	-0.7	0.3	0.3	0.7	0.1	0.3	-0.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.6	-1.3	-0.8	-0.8	-0.7	-0.6	-0.5	0.3	-0.6	-0.0	-0.7	-0.9	-0.7	-0.4	-0.2	-0.5	-0.8	-0.6	-0.5	-0.4
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	2.0	-1.0	0.2	-0.3	-0.2	0.5	-0.5	0.7	-0.7	-0.7	-0.3	-0.6	-0.0	-1.4	-0.2	-0.3	-0.1	-0.9	-0.4	0.1
Diabetes (father)	0.3	0.4	1.4	0.1	-0.3	0.9	0.7	0.2	0.8	0.7	0.0	-0.9	0.8	-0.3	0.6	0.1	0.1	0.9	-0.1	-0.4	0.9	-1.2
Severe depression (siblings)	0.3	0.3	1.8	0.2	0.1	-0.5	0.1	-0.2	0.4	-1.0	-0.3	1.3	-0.6	0.4	0.3	0.0	1.0	0.2	0.2	0.6	0.2	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	5.7	-0.4	-0.7	0.7	0.4	-1.3	0.6	-2.4	-0.7	-0.1	-0.2	0.3	0.6	-0.9	1.2	0.6	-0.1	-0.6	0.6	-1.3
Stomach or abdominal pain in last month	0.3	0.4	2.2	-0.5	0.6	-0.5	0.1	0.2	-0.2	0.6	1.5	0.7	0.6	-0.6	-0.1	-1.1	-1.0	-0.2	0.4	0.6	-0.2	0.6
High blood pressure (mother)	0.3	0.4	2.1	0.8	1.5	-0.2	0.0	0.7	-0.3	0.2	0.2	0.7	-0.0	0.4	1.0	-0.7	0.2	-0.3	0.7	-0.3	-0.3	1.1
Had other major operations	0.3	0.4	1.3	-0.8	-0.8	-0.5	-0.4	-0.2	-0.2	0.6	-0.3	-0.6	-0.2	-0.9	-1.1	0.9	-0.5	-0.2	-0.6	-0.5	-0.1	-0.8
Forced vital capacity (FVC)	0.3	1.1	5.9	0.4	2.4	0.0	0.3	-0.5	0.0	0.9	2.2	0.9	1.5	0.7	0.4	-0.4	-1.7	-0.1	0.4	1.2	-0.1	0.4
Illnesses of siblings	0.3	0.5	1.5	0.6	-0.3	0.8	0.7	0.1	0.9	-0.1	-0.4	0.2	0.2	0.9	1.2	-0.7	1.2	0.8	0.5	0.2	0.8	-0.7
Impedance of arm (right)	0.3	1.4	8.6	2.9	-0.2	1.4	0.2	-1.6	0.5	-0.9	1.0	0.6	1.0	2.0	1.8	-1.1	0.7	0.3	-0.1	0.8	0.3	0.2
Hair/balding pattern: Pattern 3	0.3	0.4	1.4	-0.4	-1.0	-0.2	-0.3	1.2	-0.4	-1.0	-1.2	-0.5	-0.7	-0.3	-0.0	0.3	0.9	-0.3	0.3	-0.5	-0.4	0.7
Impedance of arm (left)	0.3	1.2	6.0	2.4	0.2	1.2	0.2	-1.2	0.4	-0.7	1.2	1.1	1.1	2.2	1.8	-0.4	0.5	0.2	0.0	1.1	0.2	0.7
Tense / ‘highly strung’	0.3	0.5	2.9	-0.4	-0.3	-0.2	-0.3	1.7	-0.6	0.8	-1.0	0.0	-0.6	-0.5	-0.0	-1.4	0.8	-0.5	0.5	-0.2	-0.5	0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.4	1.0	-0.0	0.5	0.4	1.2	0.2	-0.9	0.0	0.3	0.3	0.6	0.5	1.1	0.7	0.4	0.6	0.4	0.3	0.2
Blood clot in the leg (DVT)	0.3	0.4	1.9	0.5	-0.4	0.3	0.5	1.0	0.5	-0.8	-0.4	-0.6	0.1	0.5	-0.6	0.9	0.8	0.6	0.2	0.1	0.6	-1.4
Birth weight	0.3	0.6	3.0	-0.5	-0.8	0.1	-0.0	-0.9	0.2	-0.7	-1.4	0.3	-0.6	1.2	-0.1	1.6	1.7	0.2	0.1	-0.4	0.2	0.4
High blood pressure (siblings)	0.3	0.4	1.3	-0.7	-0.2	-0.7	-0.7	-0.8	-0.6	-0.4	0.1	-0.5	-0.1	-0.7	-1.2	0.6	-1.0	-0.6	-0.9	-0.3	-0.6	0.3
Medication: Omeprazole	0.3	0.4	1.8	0.6	0.4	-0.1	0.0	0.9	-0.2	-0.5	1.3	0.5	0.1	-0.1	0.9	-0.0	-0.1	-0.2	0.4	0.5	-0.2	1.3
Overall health rating	0.3	0.6	3.9	0.9	-0.7	0.9	0.5	0.8	0.8	0.2	-0.3	-0.7	0.7	-0.5	0.4	-0.1	-0.2	0.9	-0.5	-0.1	0.9	-2.0
Diabetes diagnosed by doctor	0.3	0.6	3.0	-0.9	0.6	-0.7	-0.4	1.3	-0.7	1.7	-0.5	-0.6	-0.3	-1.0	-0.0	-0.9	-0.4	-0.6	0.1	-0.5	-0.6	0.4
Back pain experienced in last month	0.3	0.4	2.2	0.6	0.7	0.1	0.4	1.5	0.0	-0.9	0.5	0.4	0.5	0.6	0.6	0.5	0.4	0.1	1.2	0.7	0.1	0.5
Medication: Gliclazide	0.3	0.3	1.6	0.2	-0.0	0.2	0.2	1.1	0.2	1.2	0.6	-0.1	0.4	0.1	0.9	-0.9	0.3	0.3	0.4	-0.2	0.3	1.1
Arm fat mass (left)	0.3	1.4	4.2	1.3	1.7	-0.6	-0.2	1.3	-0.2	-1.1	-1.3	2.0	-0.8	2.0	0.6	1.8	1.3	-0.4	0.8	0.7	-0.4	1.3
Number of self-reported non-cancer illnesses	0.3	0.5	2.6	0.3	0.6	-0.4	-0.4	1.6	-0.6	1.4	1.0	0.1	-0.3	-0.8	-0.2	-0.5	-0.8	-0.6	0.1	-0.3	-0.6	0.2
Medication: Blood pressure	0.3	0.7	5.9	-0.2	0.1	0.5	0.4	1.5	0.5	2.4	0.0	0.1	-0.4	-0.6	0.8	-1.1	0.7	0.5	0.4	0.1	0.5	-0.6
Risk taking	0.3	0.5	1.4	-1.1	0.1	-1.0	-0.5	-0.6	-0.7	-0.7	-0.8	0.1	-0.7	0.0	-0.8	-0.9	-0.4	-0.6	0.0	-0.7	-0.7	1.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	2.1	0.4	0.2	-0.2	-0.3	0.6	-0.5	0.3	1.4	0.3	0.3	-0.3	0.6	-0.7	-0.7	-0.4	-0.0	0.1	-0.4	1.5
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.9	0.8	0.1	0.6	0.7	0.7	0.7	0.5	0.4	0.5	0.1	0.2	-0.3	0.9	0.0	0.6	0.5	0.5	0.7	-0.9
HDL Cholesterol	0.2	0.3	1.8	1.1	0.7	0.4	-0.2	-0.4	-0.1	-0.6	1.4	-0.4	0.3	-0.5	0.1	-0.9	-1.0	-0.2	-0.3	0.1	-0.3	0.2
Impedance of leg (right)	0.2	0.8	6.4	1.6	-0.8	0.5	0.0	-2.5	0.4	-0.8	0.0	0.1	0.6	0.6	1.0	-1.7	0.1	0.3	-0.6	0.6	0.3	-0.2
Fed-up feelings	0.2	0.4	1.9	1.4	0.3	1.0	0.5	1.1	0.5	0.7	0.5	-0.3	0.3	0.1	0.6	-1.0	0.0	0.5	0.1	0.1	0.5	-0.9
Age when periods started (menarche)	0.2	0.5	1.8	0.4	0.0	0.4	0.5	0.6	0.6	-0.6	0.2	0.7	0.4	1.0	0.5	1.4	1.2	0.6	0.8	1.0	0.6	0.2
Multivitamins +/- minerals	0.2	0.3	1.4	-0.1	-0.3	0.0	0.3	0.5	0.4	0.6	-0.3	0.5	-0.3	0.1	0.9	-0.4	1.2	0.4	0.2	0.6	0.4	-1.2
Supplements: Glucosamine	0.2	0.3	0.9	-0.0	-0.3	0.8	0.6	0.0	0.8	0.1	0.6	0.2	0.4	-0.1	0.5	0.9	0.3	0.8	0.2	0.6	0.8	-0.9
Body mass index (BMI)	0.2	1.0	5.1	-0.0	0.2	-1.1	-0.6	0.4	-0.6	-1.8	-2.3	0.4	-1.7	0.5	-0.8	1.5	1.1	-0.6	-0.1	-0.5	-0.6	0.5
Number of incorrect matches in round	0.2	0.3	1.6	-1.1	-0.5	-0.1	0.1	-0.2	-0.1	-0.4	0.8	-1.3	0.2	-0.7	-0.8	0.3	-1.0	0.1	-0.3	-0.1	0.1	-0.5
Time employed in main current job	0.2	0.2	1.2	0.6	0.3	-0.1	-0.1	-0.5	0.0	0.7	0.9	-0.3	0.4	-0.2	-0.3	-0.2	-1.1	-0.0	-0.6	-0.5	0.0	0.4
Worrier / anxious feelings	0.2	0.4	2.0	-0.2	-0.7	-0.4	-0.5	1.4	-0.8	0.3	-0.2	-0.5	-0.0	-1.0	-0.7	0.4	-0.6	-0.7	-0.1	-0.1	-0.6	1.0
Falls in the last year	0.2	0.3	2.2	0.4	-0.2	-0.3	-0.4	0.2	-0.4	-1.5	0.5	0.4	0.1	0.3	0.1	-0.9	-0.3	-0.4	-0.4	-0.1	-0.4	0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	4.1	0.3	2.0	-0.4	-0.0	-0.9	-0.4	0.5	1.7	-0.0	0.9	-0.1	-0.3	-0.1	-2.0	-0.4	-0.1	0.3	-0.4	0.7
Mouth/teeth dental problems: Dentures	0.2	0.3	2.0	0.6	0.5	0.1	0.2	0.7	0.3	1.1	1.4	0.3	0.2	0.2	0.5	-0.2	-0.2	0.2	0.3	-0.1	0.2	0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	2.5	-0.0	-0.1	-0.3	-0.5	-0.2	-0.5	-0.7	0.5	0.4	-0.4	0.4	0.2	-1.6	0.1	-0.6	-0.2	0.0	-0.6	0.7
Medication: Seretide 50 evohaler	0.2	0.3	1.5	0.5	0.4	-0.2	-0.1	1.0	-0.3	0.3	-0.0	0.8	0.3	0.1	0.4	-0.1	-0.5	-0.4	0.5	0.6	-0.3	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	1.9	-0.2	-0.4	0.2	-0.4	-0.1	-0.1	1.4	-0.9	-0.3	-0.0	0.1	0.5	-0.5	-0.2	-0.2	-0.8	-0.5	-0.2	0.1
Illnesses of siblings: Diabetes	0.2	0.3	2.7	-0.7	0.1	0.1	0.2	0.3	0.2	-1.6	-1.1	0.0	0.1	0.2	0.5	0.2	0.7	0.2	0.3	-0.1	0.2	-0.3
Smoking status: Previous	0.2	0.4	2.0	0.1	-1.4	0.6	0.4	-0.2	0.5	-0.1	-0.3	-1.2	0.1	-0.2	-0.7	0.6	0.4	0.7	-0.2	-0.1	0.7	-0.7
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.7	0.3	-0.5	-0.8	-0.6	-0.4	-0.5	0.1	-0.8	-0.1	-0.6	-0.5	-0.0	-0.3	0.5	-0.4	-0.3	-0.3	-0.4	0.3
Long-standing illness, disability or infirmity	0.2	0.4	2.3	-0.2	0.5	-0.3	0.0	0.7	0.1	0.1	0.7	0.5	0.3	-0.7	-0.6	1.5	-0.7	-0.0	-0.0	0.5	-0.0	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.5	-0.1	-1.2	0.2	-0.2	-0.4	-0.1	0.2	-0.3	-0.5	0.0	-0.4	-0.5	-0.7	0.4	0.0	-0.7	-0.7	0.0	-0.8
Miserableness	0.2	0.4	3.1	0.5	0.3	-0.6	-0.6	-0.3	-0.6	-0.4	-0.2	0.2	-0.6	-0.0	0.6	-1.8	0.1	-0.7	-0.3	-0.5	-0.7	0.6
Financial situation satisfaction	0.2	0.3	1.7	0.3	0.7	0.2	0.3	0.1	0.1	-0.4	0.7	0.0	1.1	0.5	0.7	-1.3	-0.4	0.1	0.3	0.6	0.1	0.4
Medication: Bendroflumethiazide	0.2	0.3	1.2	0.6	1.1	-0.6	-0.2	1.1	-0.4	0.4	0.2	0.3	0.1	-0.4	0.3	0.2	-0.3	-0.5	0.2	0.2	-0.5	0.7
Diastolic blood pressure, automated reading	0.2	0.5	4.4	0.4	1.0	-0.6	-0.4	0.4	-0.5	2.1	0.2	1.0	-0.5	0.3	0.4	0.1	0.1	-0.6	0.1	-0.3	-0.6	1.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	1.1	0.1	-0.4	-0.0	0.1	0.6	0.2	-0.7	-0.6	-0.6	-0.2	0.4	-0.7	0.5	0.8	0.2	0.1	-0.1	0.2	-1.0
Impedance of whole body	0.2	1.2	5.2	2.3	-0.1	1.2	0.4	-1.6	0.6	-1.0	0.9	0.8	1.2	1.8	1.8	-0.8	0.5	0.5	0.1	1.2	0.5	0.2
Ulcerative Colitis (UC)	0.1	0.3	1.9	-0.3	0.5	0.3	0.4	0.5	0.2	1.4	0.6	0.7	0.2	-0.1	0.1	0.4	-0.5	0.2	0.4	0.8	0.2	0.4
Ulcerative Colitis	0.1	0.1	0.8	-0.5	-0.3	0.1	-0.2	0.3	-0.3	0.9	-0.4	-0.1	-0.6	-0.6	-0.1	-0.5	-0.2	-0.2	-0.2	-0.0	-0.2	0.3
Systolic blood pressure, automated reading	0.1	0.4	1.8	-0.1	0.5	0.0	0.2	1.0	-0.0	1.3	0.6	-0.5	0.3	-0.8	-0.4	1.4	-0.5	0.1	0.4	-0.4	0.0	-0.1
Impedance of leg (left)	0.1	0.7	5.7	1.2	-0.8	0.2	-0.1	-2.4	0.2	-0.9	-0.4	0.1	0.4	0.4	0.8	-1.7	-0.0	0.1	-0.6	0.4	0.1	-0.3
Past tobacco smoking	0.1	0.2	1.0	0.9	1.0	0.2	0.1	0.4	0.1	0.5	0.1	0.8	0.4	0.1	0.7	-0.4	-0.2	0.1	-0.0	0.0	0.1	-0.4
Alcohol usually taken with meals	0.1	0.2	1.2	1.1	0.8	0.1	0.2	0.1	0.3	0.2	0.5	0.2	0.6	0.3	0.7	-0.2	-0.2	0.2	-0.3	0.2	0.2	-0.6
Heart attack	0.1	0.1	0.5	0.5	-0.2	0.1	0.1	0.7	0.1	0.5	0.3	0.4	-0.4	0.0	-0.5	0.4	-0.1	0.0	0.2	0.1	0.1	-0.2
Shortness of breath walking on level ground	0.1	0.1	1.1	-0.4	-1.1	-0.2	-0.4	0.1	-0.3	-0.3	0.2	-0.1	-0.0	-0.1	0.0	0.2	0.0	-0.2	-0.3	-0.1	-0.2	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.5	0.6	0.0	-0.1	-0.1	-0.1	0.1	-0.6	-0.5	-0.4	0.1	-0.3	0.1	0.3	-0.5	0.0	-0.5	-0.2	0.1	-0.7
Commuting to job workplace: Walk	0.1	0.1	0.8	0.0	0.0	0.1	0.1	0.0	0.2	0.3	0.3	0.5	-0.2	0.7	-0.1	0.2	0.9	0.2	0.4	0.7	0.2	0.1
Average weekly champagne plus white wine intake	0.1	0.2	0.8	-0.1	0.1	0.0	0.5	-0.0	0.4	-0.9	-0.4	-0.4	-0.2	-0.1	0.4	-0.5	0.2	0.5	0.5	0.2	0.5	-0.4
Ever smoked	0.1	0.3	1.5	-1.2	0.1	-0.8	-0.3	0.0	-0.5	-0.0	-0.1	-0.1	-0.3	-0.1	-0.6	-0.3	-0.3	-0.6	0.4	0.4	-0.6	0.8
Tanning	0.0	0.3	1.4	0.3	0.6	0.5	0.6	1.0	0.3	-0.1	1.2	-0.3	0.9	0.8	0.6	-0.3	0.1	0.4	0.6	0.7	0.4	-0.2

Hub : Genes

TSEN2

Models

Trait associations