TWAS hub - VILL

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2570	0.0390	0.0e+00	0.377	0.302	0.367	0.371	0.384	1.8e-48	2.7e-37	6.6e-47	1.8e-47	1.9e-49
2	GTEx	Brain Caudate basal ganglia	0.3460	0.0830	6.1e-05	0.381	NA	0.297	NA	0.327	6.3e-12	NA	3.3e-09	NA	3.9e-10
3	GTEx	Brain Cortex	0.3320	0.0890	1.5e-04	0.292	NA	0.153	NA	0.247	9.8e-09	NA	5.1e-05	NA	1.8e-07
4	GTEx	Brain Frontal Cortex BA9	0.3129	0.0853	1.3e-04	0.300	NA	0.340	NA	0.337	1.2e-08	NA	7.9e-10	NA	9.7e-10
5	GTEx	Brain Nucleus accumbens basal ganglia	0.3060	0.0950	8.5e-04	0.131	NA	0.026	NA	0.116	2.4e-04	NA	6.6e-02	NA	5.2e-04
6	GTEx	Brain Putamen basal ganglia	0.3810	0.1400	3.5e-03	0.310	NA	0.063	NA	0.258	4.0e-08	NA	1.4e-02	NA	7.9e-07
7	GTEx	Esophagus Mucosa	0.2830	0.0660	2.0e-06	0.015	NA	0.030	NA	0.035	3.2e-02	NA	4.0e-03	NA	2.0e-03
8	GTEx	Lung	0.1469	0.0545	3.1e-03	0.093	NA	0.035	NA	0.069	1.3e-07	NA	1.1e-03	NA	5.6e-06
9	ROSMAP	Brain Pre-frontal Cortex	0.3416	0.0413	0.0e+00	0.459	0.381	0.431	0.445	0.456	6.5e-66	8.1e-52	1.1e-60	4.2e-63	3.1e-65
10	TCGA	Brain Lower Grade Glioma	0.0284	0.0199	9.6e-03	0.008	0.012	0.004	NA	0.007	3.7e-02	1.5e-02	9.2e-02	NA	4.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Sitting height	9.5	67.5	95.2	-8.9	-9.3	-9.5	-9.8	-8.9	-8.0	4.2	-0.2	-8.8	-9.1
Standing height	6.0	60.0	79.0	-8.6	-8.7	-8.5	-8.6	-8.9	-7.8	5.4	1.7	-8.4	-7.8
Height	5.9	114.0	153.8	-11.8	-12.0	-11.8	-12.3	-12.4	-10.6	6.5	1.5	-11.5	-11.1
Maternal smoking around birth	4.9	7.1	11.4	-2.9	-2.9	-2.8	-2.7	-2.5	-2.9	3.4	0.9	-2.7	-2.1
Comparative height size at age 10	4.6	25.3	38.1	-5.4	-5.6	-5.6	-5.7	-6.2	-4.8	3.4	0.5	-5.3	-5.3
Medication: Atorvastatin	4.5	5.5	9.5	-2.3	-2.5	-2.9	-3.0	-2.5	-1.8	0.7	-1.5	-2.2	-3.1
Handedness (chirality/laterality): Left-handed	3.8	4.6	6.6	2.5	2.2	1.7	1.6	2.2	2.4	-2.6	-2.2	2.3	1.7
Time employed in main current job	3.6	4.2	6.0	-2.1	-2.2	-2.2	-2.2	-2.2	-2.0	2.5	0.5	-2.2	-1.8
Pulse wave peak to peak time	3.5	4.1	14.4	-1.9	-1.6	-0.8	-0.8	-0.7	-2.4	3.0	3.8	-2.0	-0.3
Arm fat-free mass (right)	3.4	17.7	24.8	-4.7	-4.6	-4.4	-4.2	-5.0	-4.2	4.4	1.1	-4.3	-3.9
Medication: Ramipril	3.3	4.2	5.8	-2.4	-2.3	-2.2	-2.1	-1.3	-2.4	2.4	1.3	-2.3	-1.1
Stomach or abdominal pain in last month	3.2	4.0	6.6	-2.2	-2.2	-1.9	-1.8	-2.2	-2.3	2.6	1.3	-2.2	-0.9
Eye problems/disorders: None of the above	3.1	3.6	7.7	-1.7	-1.6	-1.3	-1.4	-2.3	-2.1	2.8	2.1	-1.9	-1.4
Arm predicted mass (right)	3.1	15.9	22.1	-4.5	-4.4	-4.1	-3.8	-4.7	-4.0	4.4	1.3	-4.1	-3.4
Trunk predicted mass	3.0	17.0	24.8	-4.6	-4.4	-4.0	-3.7	-4.8	-4.2	5.0	2.1	-4.2	-3.3
Trunk fat-free mass	2.9	16.8	24.6	-4.6	-4.4	-4.0	-3.7	-4.8	-4.2	5.0	2.0	-4.2	-3.4
Glaucoma (self-reported)	2.9	3.4	5.2	1.9	1.8	1.1	1.1	2.3	2.2	-2.2	-2.0	2.0	1.2
Osteoarthritis (self-reported)	2.9	3.7	8.4	1.4	1.8	2.3	2.7	1.9	1.2	-0.1	1.6	1.7	2.9
Mother’s age at death	2.9	3.6	8.3	1.8	1.8	1.3	1.6	2.2	2.1	-2.9	-1.7	1.9	0.6
Had menopause	2.7	3.4	5.8	-1.7	-1.9	-2.2	-2.4	-2.1	-1.5	-0.3	-0.7	-1.9	-2.4
Illnesses of father: High blood pressure	2.7	3.4	6.8	2.0	1.8	1.1	1.1	2.6	2.1	-1.7	-2.5	1.9	0.6
Hand grip strength (right)	2.5	6.8	9.6	-2.8	-2.8	-2.6	-2.5	-3.1	-2.5	2.8	0.8	-2.6	-2.8
Eye problems/disorders: Cataract	2.5	2.9	8.8	1.4	1.3	0.7	0.6	1.0	1.9	-2.9	-3.0	1.5	0.2
Arm predicted mass (left)	2.5	12.6	18.3	-4.0	-3.9	-3.5	-3.2	-4.2	-3.7	4.3	1.6	-3.6	-2.7
Ever used hormone-replacement therapy (HRT)	2.4	3.1	4.5	-1.8	-2.0	-2.0	-2.0	-1.4	-1.7	1.6	-0.1	-1.9	-2.1
Pain type(s) experienced in last month: Hip pain	2.4	3.1	4.5	-1.9	-1.8	-1.4	-1.7	-1.9	-2.0	2.1	1.4	-1.9	-1.1
Arm fat-free mass (left)	2.4	12.2	17.6	-3.9	-3.8	-3.5	-3.2	-4.2	-3.5	4.2	1.3	-3.5	-2.9
Lupus	2.3	3.5	4.8	-2.1	-2.2	-2.1	-2.0	-2.0	-2.0	1.9	0.5	-2.1	-1.0
Whole body fat-free mass	2.3	13.3	19.8	-4.0	-3.9	-3.7	-3.5	-4.5	-3.6	4.1	1.3	-3.7	-3.3
Whole body water mass	2.3	13.1	19.5	-4.0	-3.9	-3.6	-3.4	-4.4	-3.6	4.1	1.3	-3.7	-3.2
Supplements: Zinc	2.2	2.4	3.5	1.6	1.6	1.3	1.3	1.9	1.9	-1.4	-1.7	1.8	0.6
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.5	4.7	-1.3	-1.6	-2.0	-2.2	-1.8	-1.0	0.5	-1.6	-1.4	-1.8
Mean time to correctly identify matches	2.2	4.2	7.6	2.3	2.3	2.1	1.9	1.8	2.2	-2.8	-1.2	2.2	1.3
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.6	8.3	-2.2	-2.4	-2.6	-2.8	-2.1	-1.6	0.5	-0.9	-2.1	-2.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.6	5.1	-1.7	-1.6	-1.2	-0.8	-1.4	-2.0	2.2	2.0	-1.7	-0.3
Basal metabolic rate	2.2	12.1	18.6	-3.8	-3.7	-3.6	-3.4	-4.3	-3.4	3.7	1.0	-3.5	-3.3
Forced vital capacity (FVC)	2.1	8.1	10.2	-3.2	-3.1	-2.8	-2.9	-3.0	-2.8	3.1	1.1	-3.1	-2.7
Eye problems/disorders: Glaucoma	2.1	2.5	5.1	1.7	1.6	1.1	1.3	2.2	1.9	-1.4	-1.2	1.8	1.2
Pulse wave Arterial Stiffness index	2.0	2.4	12.2	1.1	0.8	0.1	0.0	-0.1	1.6	-2.4	-3.5	1.2	-0.3
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	5.6	-1.6	-1.5	-1.1	-1.2	-2.1	-1.5	2.4	0.9	-1.5	-1.1
Medication for hormone replacement therapy	1.9	2.1	5.7	-1.4	-1.5	-1.7	-1.5	-1.3	-1.1	0.7	-0.5	-1.3	-2.4
Diabetes (mother)	1.9	2.4	3.7	-1.4	-1.5	-1.7	-1.9	-1.5	-1.5	1.6	0.0	-1.6	-1.9
Forced vital capacity (FVC), Best measure	1.9	7.0	10.8	-2.9	-2.9	-2.9	-3.2	-3.0	-2.2	1.9	0.1	-2.7	-3.3
Age at last live birth	1.9	2.7	5.6	1.7	1.8	1.7	1.9	1.5	1.7	-2.4	-0.2	1.8	1.0
Reaction Time	1.8	3.5	4.7	2.1	2.0	1.9	1.9	1.7	2.0	-2.2	-1.0	2.1	1.3
Back pain experienced in last month	1.8	2.6	5.5	-1.7	-1.5	-0.9	-0.8	-1.5	-1.9	2.3	2.3	-1.6	-0.3
Relative age voice broke	1.7	2.6	3.2	1.8	1.7	1.7	1.7	1.8	1.8	-1.8	-1.0	1.7	0.8
Falls in the last year	1.7	2.3	5.2	1.1	1.4	1.8	2.0	1.6	1.0	-0.2	1.4	1.4	2.3
Weight	1.6	7.7	13.3	-3.0	-3.0	-3.0	-2.8	-3.6	-2.6	2.5	0.6	-2.8	-2.7
Tense / ‘highly strung’	1.6	2.6	7.0	-1.9	-1.6	-1.3	-0.8	-1.3	-1.6	2.6	1.6	-1.2	-1.3
Loud music exposure frequency	1.6	1.8	3.6	1.3	1.4	1.5	1.4	1.9	1.2	-0.9	-0.2	1.3	1.6
Knee pain experienced in last month	1.6	2.5	10.2	-1.1	-0.9	-0.1	-0.0	-0.8	-1.6	2.6	3.2	-1.1	1.2
Myopia	1.6	2.4	4.1	1.8	1.7	1.3	1.2	2.0	1.7	-1.6	-0.9	1.6	1.2
Leg fat-free mass (left)	1.5	7.7	13.1	-2.8	-2.9	-3.1	-3.0	-3.6	-2.5	2.4	0.1	-2.8	-3.1
Leg predicted mass (left)	1.5	8.1	13.4	-2.9	-3.0	-3.1	-3.0	-3.7	-2.5	2.6	0.2	-2.9	-3.1
Nervous feelings	1.5	2.9	12.3	-0.0	0.5	1.4	1.7	0.8	-0.3	2.7	3.5	0.4	1.6
Health satisfaction	1.5	1.9	2.8	1.3	1.4	1.6	1.7	1.7	1.5	-0.8	0.0	1.6	1.5
Medication: Seretide 50 evohaler	1.5	1.8	3.9	-1.3	-1.4	-1.2	-1.4	-2.0	-1.6	0.7	0.8	-1.5	-0.6
Worry (Nagel 2018)	1.4	2.9	6.1	-1.9	-1.7	-1.2	-0.8	-1.8	-1.9	2.0	2.5	-1.6	-0.8
Age at First Birth	1.4	2.1	3.7	1.4	1.5	1.9	1.8	1.9	1.0	-1.2	0.6	1.4	1.0
Bipolar Disorder (2011)	1.4	1.4	2.2	1.3	1.3	1.3	1.4	0.9	1.2	-0.4	0.2	1.4	1.5
Exposure to tobacco smoke outside home	1.4	1.9	4.1	-1.2	-1.4	-1.7	-1.5	-1.7	-1.0	-0.4	-0.7	-1.2	-2.0
Leg fat-free mass (right)	1.4	7.3	12.1	-2.7	-2.8	-3.0	-2.9	-3.5	-2.4	2.3	0.1	-2.7	-3.1
Leg predicted mass (right)	1.4	7.4	12.5	-2.8	-2.9	-3.0	-3.0	-3.5	-2.4	2.4	0.1	-2.7	-3.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.2	9.9	-2.0	-2.1	-2.4	-2.6	-2.1	-1.4	0.8	-0.6	-1.9	-3.1
Exposure to tobacco smoke at home	1.3	1.4	2.3	1.2	1.3	1.4	1.5	1.3	0.8	-0.8	1.1	1.1	1.3
Migraine (self-reported)	1.3	1.6	4.7	1.3	1.3	0.8	0.8	0.9	1.5	-2.2	-1.0	1.3	0.8
Diabetes (father)	1.2	1.4	2.4	1.5	1.5	1.6	1.3	1.0	1.3	0.0	0.2	1.4	1.2
Trunk fat mass	1.2	4.9	8.8	-2.3	-2.4	-2.6	-2.8	-3.0	-1.9	0.8	-0.4	-2.2	-2.5
Forced expiratory volume in 1-second (FEV1)	1.2	3.9	5.4	-2.1	-2.1	-2.0	-2.1	-1.9	-1.8	2.1	0.6	-2.1	-2.3
Shortness of breath walking on level ground	1.2	1.4	3.9	-0.8	-1.0	-1.4	-1.2	-2.0	-0.3	0.7	-1.4	-0.6	-1.6
Hypertension (Self-reported)	1.2	3.4	4.9	-2.2	-2.1	-2.1	-2.1	-1.6	-1.8	2.0	0.2	-2.0	-1.4
Neuroticism (2016)	1.1	1.7	3.2	1.5	1.5	1.2	1.4	0.9	1.6	-0.2	-0.9	1.8	1.1
Illnesses of siblings	1.1	1.5	5.0	0.9	1.1	1.5	1.4	0.7	0.6	-1.0	1.3	0.8	2.2
Number of live births	1.1	1.5	3.2	0.8	1.0	1.7	1.6	0.8	0.5	0.8	1.8	0.9	1.6
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.6	0.0	-0.2	-0.8	-1.0	-1.1	0.3	-1.9	-1.9	-0.1	-1.8
Medication for cholesterol	1.1	1.6	2.3	1.4	1.4	1.5	1.2	1.4	1.0	-1.5	0.4	1.1	1.3
Osteoporosis (self-reported)	1.1	1.4	2.1	-1.4	-1.4	-1.3	-1.1	-0.7	-1.5	0.9	0.8	-1.4	-1.0
Guilty feelings	1.1	1.6	3.8	1.2	1.4	1.4	1.9	1.0	1.4	-0.1	0.3	1.6	1.1
Basal cell carcinoma (self-reported)	1.1	1.3	2.1	-1.4	-1.2	-0.9	-0.9	-1.3	-1.4	0.9	1.0	-1.4	-0.3
Ulcerative Colitis (UC)	1.0	1.8	2.6	1.5	1.4	1.6	1.5	1.6	1.4	-0.6	-0.0	1.3	1.6
Ovarian Cancer	1.0	1.3	3.4	1.1	1.1	0.8	0.9	1.8	1.3	-1.0	-0.4	1.3	0.9
Primary Biliary Cirrhosis	1.0	1.4	2.3	-1.2	-1.2	-1.4	-1.3	-1.3	-1.1	0.2	0.4	-1.3	-1.5
Hand grip strength (left)	1.0	2.7	6.9	-1.7	-1.6	-1.3	-1.2	-1.5	-1.7	2.6	1.4	-1.6	-1.1
Pack years adult smoking proportion	1.0	1.5	2.0	1.4	1.3	1.1	0.9	1.4	1.3	-1.4	-1.2	1.3	0.6
High blood pressure	1.0	2.8	4.1	-2.0	-1.9	-1.9	-1.9	-1.3	-1.7	1.9	0.3	-1.8	-1.1
Supplements: Glucosamine	1.0	1.4	2.4	1.3	1.3	1.6	1.3	1.5	1.0	-0.6	-0.2	1.1	1.0
Pulse wave reflection index	1.0	1.2	5.4	0.1	-0.2	-0.7	-0.7	-0.4	0.3	-2.1	-2.3	-0.0	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.3	-1.0	-0.9	-0.6	-0.6	-0.6	-1.5	1.4	1.8	-1.2	0.4
Asthma (self-reported)	1.0	2.0	4.1	-1.5	-1.5	-1.2	-0.9	-1.6	-1.7	2.0	1.0	-1.6	-0.6
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	4.5	0.7	0.8	1.1	1.3	0.8	0.5	0.3	1.4	0.9	2.1
Blood White Count	0.9	6.9	9.2	-2.9	-3.0	-3.0	-2.9	-2.6	-2.5	2.4	-0.0	-2.7	-2.9
Allergy or Eczema	0.9	2.3	4.3	-1.6	-1.6	-1.6	-1.5	-2.1	-1.5	0.8	0.2	-1.6	-1.9
Average weekly spirits intake	0.9	1.1	2.9	-1.0	-0.9	-0.5	-0.6	-1.1	-1.1	1.7	1.3	-0.9	-1.0
Angina	0.9	1.1	3.2	-0.4	-0.7	-1.3	-1.4	-1.0	-0.1	-0.0	-1.8	-0.5	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	4.1	-1.2	-0.9	-0.4	-0.2	-1.3	-1.2	2.0	1.9	-0.8	0.3
Asthma	0.9	1.8	3.3	-1.3	-1.4	-1.2	-0.9	-1.7	-1.6	1.8	0.8	-1.5	-0.5
Number of children fathered	0.9	1.0	2.7	0.7	0.8	1.3	1.3	0.6	0.2	0.9	1.6	0.4	1.2
Overall health rating	0.9	2.0	3.7	-1.7	-1.5	-1.2	-0.9	-1.3	-1.6	1.9	1.7	-1.3	-0.2
Wears glasses or contact lenses	0.9	1.0	2.5	-1.1	-1.0	-0.8	-0.4	-1.2	-1.1	1.6	0.9	-0.9	-0.4
Alcohol drinker status: Never	0.9	1.1	1.6	-1.3	-1.2	-1.2	-1.2	-0.9	-1.2	0.8	0.5	-1.2	-0.9
Fractured/broken bones in last 5 years	0.9	1.2	1.9	1.2	1.2	1.1	1.2	0.8	1.4	-1.0	-0.5	1.4	0.8
Unable to work because of sickness or disability	0.9	1.2	2.2	-0.9	-1.1	-1.3	-1.4	-0.9	-0.8	-0.9	-0.9	-0.8	-1.5
Pain experienced in last month	0.9	1.5	8.1	0.6	0.4	-0.5	-0.6	0.6	1.1	-1.8	-2.8	0.6	-0.6
Prostate Cancer	0.8	1.1	2.0	1.1	1.1	1.0	0.8	0.8	1.2	-1.4	-1.0	1.2	0.7
Crohns Disease (2012)	0.8	1.3	2.5	-1.4	-1.4	-1.2	-1.2	-0.2	-1.4	0.5	0.4	-1.3	-1.6
Systolic Blood Pressure	0.8	4.0	7.3	-2.0	-2.2	-2.5	-2.5	-1.1	-1.7	0.7	-1.1	-2.2	-2.7
Smoking Status	0.8	1.8	3.2	-1.5	-1.4	-1.1	-1.0	-1.8	-1.5	1.2	1.8	-1.1	-0.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.9	-0.8	-0.9	-1.3	-1.4	-0.6	-0.5	0.1	-1.3	-0.7	-1.1
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	2.5	-0.8	-1.0	-1.2	-1.5	-0.4	-0.7	0.3	-0.6	-0.9	-1.6
Number of incorrect matches in round	0.8	1.2	2.0	-1.3	-1.2	-1.2	-1.3	-1.1	-1.0	0.7	0.3	-1.1	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.5	0.7	0.9	1.4	1.6	0.4	0.4	1.2	1.4	1.0	1.3
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	3.8	0.5	0.2	-0.4	-0.6	0.5	0.8	-1.7	-1.9	0.5	-1.3
Breastfed as a baby	0.8	1.0	2.3	1.0	1.1	1.4	1.5	0.5	0.9	0.3	0.6	1.1	0.9
Medication: Ventolin 100micrograms inhaler	0.8	1.0	4.2	-0.5	-0.4	0.3	0.4	-0.6	-0.9	2.0	1.8	-0.5	0.8
Medication: Blood pressure	0.8	1.5	2.4	-1.5	-1.4	-1.4	-1.5	-0.7	-1.3	1.2	0.8	-1.3	-0.2
Angina (self-reported)	0.8	1.0	2.5	-0.5	-0.7	-1.3	-1.4	-0.9	-0.2	0.3	-1.6	-0.5	-1.5
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.6	0.6	0.7	1.0	1.0	0.5	0.4	-1.6	0.7	0.7	1.5
Medication: Lisinopril	0.8	1.1	3.2	0.9	0.8	0.3	0.1	0.7	1.3	-1.6	-1.8	1.0	0.4
Average weekly beer plus cider intake	0.8	1.2	2.6	-1.0	-1.1	-1.4	-1.2	-1.6	-1.2	0.9	0.0	-1.2	-0.4
Commuting to job workplace: Cycle	0.8	1.0	3.7	-0.7	-0.8	-0.8	-1.1	-1.4	-0.4	-0.7	-0.7	-0.7	-1.9
Bipolar Disorder or Schizophrenia	0.7	1.8	6.6	0.4	0.7	1.4	1.8	0.7	-0.1	1.3	2.6	0.5	1.7
Blood Red Count	0.7	7.0	11.3	-2.7	-2.9	-3.1	-2.9	-2.7	-2.5	3.4	-0.2	-2.8	-1.6
Severe depression (siblings)	0.7	0.8	2.5	-0.9	-0.9	-1.0	-1.0	-1.0	-0.6	0.3	-0.4	-0.7	-1.6
Had other major operations	0.7	0.8	3.9	-0.2	0.1	0.6	0.7	-0.1	-0.4	0.4	2.0	-0.1	1.8
Allergy	0.7	1.6	4.3	1.1	1.0	0.4	0.2	1.7	1.5	-1.6	-2.1	1.2	0.4
Happiness	0.7	0.9	1.4	1.0	1.0	0.8	1.0	0.9	1.1	-0.3	-1.1	1.2	0.5
Medication: Lansoprazole	0.7	0.8	5.9	0.3	0.1	-0.5	-0.5	0.1	0.8	-0.6	-2.4	0.4	-0.7
Whole body fat mass	0.7	2.8	5.2	-1.7	-1.7	-1.9	-2.0	-2.3	-1.4	0.9	-0.3	-1.6	-1.9
Number of full sisters	0.7	0.9	1.5	1.0	1.0	0.9	0.8	1.2	0.9	-0.7	-0.8	0.9	0.9
Mineral and other dietary supplements	0.7	1.0	2.5	-0.6	-0.8	-1.1	-1.1	-1.6	-0.4	-0.8	-0.7	-0.7	-1.4
Miserableness	0.7	1.1	2.0	1.1	1.2	1.1	1.3	1.2	1.2	-0.1	-0.0	1.4	0.9
Commuting to job workplace: Public transport	0.7	0.9	1.6	0.8	1.0	1.1	1.0	1.3	0.9	-0.3	0.4	1.2	0.9
Vascular/heart problems diagnosed by doctor	0.7	1.8	2.9	1.6	1.5	1.7	1.7	0.9	1.2	-1.4	0.6	1.4	1.0
Bipolar Disorder (2018)	0.6	1.0	2.2	0.7	0.9	1.3	1.2	0.4	0.5	0.2	1.5	0.8	1.4
LDL Cholesterol	0.6	0.9	2.4	-1.0	-0.9	-1.0	-0.6	-0.9	-1.0	1.6	0.9	-0.9	-0.6
Triglycerides	0.6	1.0	3.4	0.4	0.6	1.0	1.1	1.1	-0.0	1.1	1.9	0.3	1.2
Ever had hysterectomy (womb removed)	0.6	0.7	2.2	-0.7	-0.7	-0.7	-0.8	-0.8	-0.6	1.5	-0.1	-0.8	-1.1
Systolic blood pressure, automated reading	0.6	1.8	2.8	-1.4	-1.5	-1.7	-1.6	-1.0	-1.1	1.1	-0.7	-1.4	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	3.4	-0.1	0.2	0.6	0.8	-0.1	-0.3	1.4	1.8	0.2	0.9
Mouth/teeth dental problems	0.6	0.9	4.0	0.2	0.4	0.8	1.0	0.8	0.2	2.0	1.1	0.4	0.9
Pain all over the body in last month	0.6	0.6	1.2	0.9	0.9	0.6	0.6	0.9	1.1	-0.5	-0.8	1.1	-0.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.6	-0.8	-0.8	-0.6	-0.7	-1.9	-0.8	0.5	0.2	-0.9	-0.8
Mouth/teeth dental problems: Dentures	0.6	0.9	4.4	0.6	0.3	-0.3	-0.5	-0.5	0.8	-1.8	-2.1	0.4	-0.4
Depression (self-reported)	0.6	0.8	1.4	0.9	0.9	0.7	0.6	0.8	1.0	-1.2	-1.0	1.1	0.1
Blood clot in the leg (DVT)	0.6	0.8	3.2	-0.0	0.1	0.5	0.7	0.1	-0.3	1.0	1.8	0.1	1.8
Mood swings	0.6	1.1	1.6	1.1	1.2	1.2	1.3	1.0	0.9	0.7	0.8	1.2	1.0
Smoking status: Current	0.6	1.0	3.0	-1.1	-0.9	-0.4	-0.5	-1.2	-1.2	1.1	1.7	-0.8	0.1
Hearing aid user	0.6	0.7	1.2	-0.9	-0.8	-0.5	-0.5	-1.0	-1.0	1.0	1.1	-0.8	-0.3
Pack years of smoking	0.6	0.9	1.8	1.1	1.0	0.7	0.5	1.0	1.1	-1.2	-1.3	1.0	0.2
Depressed Affect (Nagel 2018)	0.5	1.1	2.0	1.0	1.1	1.1	1.4	1.3	1.0	0.2	0.1	1.4	1.1
Schizophrenia (2018)	0.5	1.1	4.4	-0.0	0.1	0.8	1.2	0.5	-0.5	1.5	2.1	0.0	1.1
Alzheimer’s Disease (in mother)	0.5	0.6	1.6	0.5	0.6	1.0	1.1	0.4	0.2	0.0	1.0	0.5	1.2
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.0	-0.8	-0.8	-0.9	-1.0	-0.5	-0.7	0.2	-0.0	-0.9	-0.7
Heel T-Score	0.5	4.3	8.6	-2.0	-1.9	-1.8	-1.8	-2.9	-1.9	2.6	1.0	-2.0	-2.2
Respiratory disease	0.5	1.1	2.1	-1.0	-1.0	-0.9	-0.6	-1.4	-1.1	1.5	0.2	-1.0	-0.9
Serious illness, injury or assault to yourself	0.5	0.6	1.1	-0.9	-0.9	-0.9	-0.8	-1.1	-0.7	0.2	-0.2	-0.8	-0.6
Hearing difficulty/problems with background noise	0.5	0.8	1.7	0.8	0.9	1.0	1.3	1.2	0.8	0.3	-0.2	0.9	0.7
Hair/balding pattern: Pattern 2	0.5	0.6	1.6	0.6	0.7	1.0	0.9	1.2	0.6	-0.3	0.6	0.7	1.0
Qualifications: None of the above	0.5	1.1	3.0	-0.6	-0.8	-0.9	-0.9	-1.6	-1.1	1.7	0.6	-0.8	0.1
Heart attack	0.5	0.6	1.8	0.4	0.5	0.7	0.8	1.0	0.3	1.3	0.7	0.6	0.9
Hip circumference	0.5	2.4	3.7	-1.7	-1.7	-1.9	-1.8	-1.9	-1.3	0.6	-0.1	-1.5	-1.8
Father’s age at death	0.5	0.7	2.4	-0.6	-0.6	-0.8	-1.0	-0.8	-0.2	-0.7	-0.8	-0.5	-1.6
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.3	1.1	1.1	1.3	1.5	0.4	0.7	-0.4	0.5	0.9	0.5
High blood pressure (siblings)	0.5	0.8	3.3	-0.3	-0.4	-0.8	-0.7	0.2	0.2	0.4	-1.8	-0.1	-1.6
Comparative body size at age 10	0.5	1.5	6.6	1.0	0.7	0.2	0.1	0.1	1.1	-2.6	-2.0	0.8	-0.9
Neck or shoulder pain in last month	0.5	0.7	4.0	-0.4	-0.2	0.3	0.5	-0.5	-0.7	1.3	2.0	-0.4	-0.2
Medication: Omeprazole	0.5	0.6	2.5	-0.2	0.1	0.6	0.9	-0.1	-0.3	1.0	1.6	0.1	1.2
Suffer from ‘nerves’	0.5	0.7	1.5	0.6	0.8	1.1	1.2	0.3	0.5	0.2	1.0	0.8	1.2
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.0	-0.9	-0.9	-1.0	-0.7	-0.6	-0.8	0.5	-0.2	-1.0	-0.6
Qualifications: nursing, teaching	0.5	0.8	3.4	0.2	0.5	1.0	1.2	0.5	-0.1	0.3	1.9	0.2	1.2
Ever taken oral contraceptive pill	0.5	0.5	1.0	-0.7	-0.7	-0.9	-1.0	-0.8	-0.4	0.0	-0.6	-0.6	-1.0
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.4	0.5	0.7	0.8	0.9	1.2	0.5	0.7	0.2	0.6	1.2
Heart attack/myocardial infarction (self-reported)	0.5	0.7	3.0	0.2	0.4	0.6	0.7	0.9	0.1	1.7	0.9	0.4	1.0
Alcohol drinker status: Previous	0.5	0.6	1.6	-0.8	-0.7	-0.8	-0.0	-1.3	-0.6	1.1	0.4	-0.4	-0.7
Depression (Nagel 2018)	0.4	0.6	1.2	0.6	0.8	0.9	1.1	0.3	0.5	0.4	0.7	0.9	1.1
Irritable Bowel Disease (IBD)	0.4	0.9	1.6	0.8	0.9	1.2	1.2	1.3	0.8	-0.1	0.2	0.8	1.2
Major Depression (MDD)	0.4	0.5	1.0	-0.7	-0.7	-0.7	-0.5	-1.0	-0.7	1.0	0.8	-0.5	-0.1
Schizophrenia (2014)	0.4	0.8	4.0	0.2	0.3	0.9	1.2	0.2	-0.3	1.1	2.0	0.2	0.8
Cardiovascular Disease	0.4	1.4	2.0	-1.4	-1.4	-1.4	-1.3	-1.0	-1.0	1.3	-0.6	-1.2	-0.9
Vitamin and mineral supplements	0.4	0.5	1.6	-0.0	-0.2	-0.4	-0.6	-1.2	0.0	-1.3	-0.7	-0.1	-0.7
Impedance of leg (right)	0.4	1.9	3.3	-1.8	-1.7	-1.2	-1.4	-1.1	-1.8	0.5	1.3	-1.7	-0.6
Trunk fat percentage	0.4	1.7	3.3	-1.1	-1.2	-1.6	-1.8	-1.7	-0.8	-0.8	-0.9	-1.1	-1.7
Current tobacco smoking	0.4	0.7	1.5	-1.0	-0.9	-0.5	-0.6	-1.2	-1.0	0.6	1.1	-0.7	-0.1
Average weekly fortified wine intake	0.4	0.4	1.4	0.6	0.5	0.5	0.6	0.7	0.6	-1.2	-0.8	0.6	-0.1
Qualifications: CSEs or equivalent	0.4	0.5	1.1	0.4	0.5	0.8	0.8	1.0	0.3	0.8	0.7	0.6	0.7
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.3	-0.9	-0.8	-0.3	-0.1	-1.1	-1.1	1.2	1.5	-0.9	-0.5
Medication: Levothyroxine sodium	0.4	0.7	1.1	-1.0	-0.9	-0.6	-0.8	-0.6	-1.1	0.6	0.9	-1.0	-0.4
High blood pressure (mother)	0.4	0.5	2.1	-0.2	-0.2	-0.5	-0.5	-0.3	0.2	-0.6	-1.5	-0.2	-1.3
Financial difficulties in last 2 years	0.4	0.6	3.6	-0.1	0.1	0.3	0.5	0.3	-0.2	1.9	1.1	0.1	0.5
Arm fat percentage (right)	0.4	1.5	2.3	1.4	1.4	1.1	1.1	0.9	1.5	-1.5	-0.7	1.4	0.8
Pulse rate	0.4	0.6	1.1	0.8	0.8	0.7	0.6	0.6	1.1	0.7	-0.9	1.0	0.5
Qualifications: A levels/AS levels or equivalent	0.4	0.9	5.8	-0.1	0.2	0.8	1.0	0.5	-0.5	0.0	2.4	-0.1	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.8	0.2	0.6	0.8	0.9	-0.4	0.4	-0.6	1.3	0.5	0.3
Illnesses of mother	0.4	0.5	2.1	0.1	0.3	0.5	0.9	0.7	0.1	0.6	1.4	0.4	0.9
Illnesses of siblings: Diabetes	0.4	0.5	2.2	0.1	-0.2	-0.6	-0.7	-0.6	0.2	0.2	-1.5	-0.2	-1.1
Smoking status: Previous	0.4	0.6	1.8	-0.6	-0.7	-1.0	-0.8	-0.9	-0.4	-0.3	-0.1	-0.5	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	2.9	-0.5	-0.3	0.2	0.1	-0.5	-0.7	0.7	1.7	-0.4	0.2
Risk taking	0.4	0.6	1.6	-0.8	-0.7	-0.5	-0.4	-1.3	-0.7	1.2	0.6	-0.5	-0.2
Impedance of whole body	0.4	1.8	3.7	-1.3	-1.5	-1.4	-1.9	-0.9	-1.3	-1.4	-0.1	-1.4	-1.4
Alzheimer’s Disease (including proxy)	0.3	0.4	1.5	-0.6	-0.6	-0.2	-0.3	-1.2	-0.7	0.2	0.8	-0.6	-0.2
Fasting Glucose	0.3	0.4	1.3	-0.1	-0.3	-0.9	-0.8	-0.1	-0.0	0.1	-1.1	-0.3	-1.1
HDL Cholesterol	0.3	0.5	2.4	0.5	0.4	0.1	-0.2	0.2	0.6	-1.6	-1.2	0.4	0.4
Rheumatoid Arthritis	0.3	0.5	2.0	-0.4	-0.3	0.0	0.0	-0.1	-0.6	1.1	1.4	-0.3	0.8
Ulcerative Colitis	0.3	0.5	1.0	0.6	0.6	1.0	0.8	0.9	0.5	-0.1	0.5	0.6	1.0
Lung FEV1/FVC ratio	0.3	1.3	4.5	0.0	-0.4	-1.2	-1.3	-1.0	0.1	-1.3	-1.6	-0.5	-2.1
Neuroticism	0.3	0.8	2.8	0.1	0.3	0.8	1.1	0.4	-0.1	1.4	1.7	0.5	0.8
Hearing difficulty/problems: Yes	0.3	0.4	1.4	-0.7	-0.5	0.1	0.1	-0.1	-0.8	1.1	1.2	-0.5	-0.1
Taking other prescription medications	0.3	0.4	1.4	0.4	0.5	0.8	0.8	0.5	0.2	0.4	0.7	0.6	1.2
Age when periods started (menarche)	0.3	0.8	3.7	0.2	0.4	0.9	1.0	0.2	-0.2	0.2	1.9	0.2	1.4
Impedance of leg (left)	0.3	1.3	2.2	-1.4	-1.4	-1.0	-1.3	-0.9	-1.5	-0.0	1.1	-1.4	-0.5
Waist circumference	0.3	1.3	3.9	-1.0	-1.1	-1.3	-1.2	-2.0	-0.8	0.4	-0.1	-0.9	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	3.2	-0.9	-0.7	-0.4	-0.1	-0.1	-0.6	1.8	0.8	-0.6	-0.6
Alcohol intake versus 10 years previously	0.3	0.5	1.4	0.6	0.7	0.5	0.5	1.2	0.8	-0.8	-0.5	0.8	0.0
Impedance of arm (left)	0.3	1.5	4.3	-0.8	-1.0	-1.2	-1.7	-0.7	-0.8	-2.1	-0.4	-1.1	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.7	0.6	0.7	0.7	0.7	0.8	0.5	0.5	0.9	0.8	0.2
Medication: Paracetamol	0.3	0.6	1.0	0.8	0.9	0.9	1.0	-0.0	0.8	-0.8	0.4	0.9	0.3
Headache pain in last month	0.3	0.5	3.0	-0.5	-0.3	-0.0	0.1	-1.7	-0.5	0.0	1.3	-0.4	0.3
Gout (self-reported)	0.3	0.4	0.8	0.7	0.7	0.5	0.6	0.7	0.8	0.3	-0.3	0.9	0.3
Number of full brothers	0.3	0.3	1.1	0.6	0.5	0.6	0.4	0.4	0.5	1.0	-0.0	0.6	0.7
Worry too long after embarrassment	0.3	0.6	1.0	0.7	0.6	0.6	0.8	1.0	0.7	-0.9	-1.0	0.7	0.3
Wheeze or whistling in the chest in last year	0.3	0.5	1.5	-0.7	-0.7	-0.6	-0.6	-1.2	-0.7	0.7	-0.1	-0.7	-0.8
Age at first live birth	0.3	0.6	5.0	0.5	0.4	0.3	0.2	0.3	0.4	-2.2	-0.4	0.3	-0.0
Heart disease (mother)	0.3	0.4	0.9	-0.5	-0.6	-0.8	-1.0	-0.4	-0.4	-0.5	-0.9	-0.6	-0.4
Had major operations	0.3	0.4	1.8	0.4	0.3	-0.1	-0.2	0.4	0.6	-0.6	-1.4	0.3	-0.7
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.5	-0.1	-0.3	-0.5	-0.8	0.4	0.0	-0.6	-1.2	-0.2	-0.8
Supplements: Vitamin C	0.3	0.4	2.0	-0.6	-0.4	-0.2	-0.2	-0.1	-0.4	1.4	0.6	-0.4	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.8	0.6	0.5	0.4	0.9	0.8	0.7	0.3	-0.3	0.7	0.7
Illnesses of father: Heart disease	0.3	0.4	1.2	0.6	0.6	0.7	0.7	0.3	0.5	0.5	0.2	0.6	1.1
Arm fat percentage (left)	0.3	1.0	2.2	1.2	1.1	0.7	0.6	0.6	1.3	-1.5	-1.0	1.1	0.2
Diabetes diagnosed by doctor	0.3	0.5	1.0	-0.7	-0.7	-0.8	-1.0	-0.6	-0.7	0.1	-0.5	-0.8	-0.6
Medication: Gliclazide	0.3	0.4	1.3	-0.7	-0.5	-0.4	-0.3	-0.6	-0.7	1.2	0.7	-0.5	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	1.7	0.7	0.8	0.8	0.6	1.3	0.9	-0.2	-0.4	0.7	0.3
Heart disease (siblings)	0.3	0.4	2.0	-0.1	-0.3	-0.7	-0.7	-0.2	0.0	0.0	-1.4	-0.2	-1.0
Mean Putamen Volume	0.2	0.2	0.5	-0.6	-0.5	-0.6	-0.6	-0.7	-0.2	0.1	0.1	-0.3	-0.4
HbA1C	0.2	0.3	0.5	0.4	0.4	0.5	0.7	0.7	0.2	-0.5	0.6	0.3	0.7
Blood Platelet Count	0.2	2.6	6.2	1.8	1.8	1.4	1.0	1.0	2.1	-2.5	-1.3	1.8	0.3
BMI	0.2	1.0	1.8	1.2	1.2	1.1	1.3	0.6	1.1	0.2	-0.1	1.2	0.9
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.7	-0.3	-0.4	-0.6	-1.0	-0.3	-0.1	-0.5	-1.3	-0.4	-0.8
Chronotype (morning person)	0.2	0.4	0.9	-0.9	-0.7	-0.5	-0.4	0.1	-0.7	1.0	0.9	-0.7	0.3
Medication: Co-codamol	0.2	0.2	0.5	0.4	0.4	0.5	0.4	0.5	0.3	0.4	0.4	0.5	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.8	-0.8	-0.6	-0.5	-0.3	-0.4	-0.5	1.4	0.3	-0.6	-1.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	0.4	0.3	0.3	0.5	0.5	0.3	-0.6	-0.5	0.4	0.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	-0.4	-0.4	-0.5	-0.6	-0.3	-0.3	0.5	-0.3	-0.3	-0.8
Body mass index (BMI)	0.2	0.8	1.3	1.1	1.1	0.9	1.1	0.4	1.1	-0.1	-0.3	1.1	0.8
Diabetes (self-reported)	0.2	0.2	0.6	-0.5	-0.5	-0.5	-0.8	-0.3	-0.5	0.1	-0.4	-0.6	-0.5
Medication: Simvastatin	0.2	0.3	0.7	0.5	0.5	0.4	0.3	0.6	0.5	-0.3	-0.5	0.5	0.9
Neuroticism score	0.2	0.4	1.6	0.1	0.2	0.5	0.8	0.2	-0.0	1.0	1.3	0.4	0.5
Medication: Cholesterol lowering	0.2	0.3	1.4	-0.0	-0.1	-0.4	-0.6	0.2	0.2	-0.7	-1.2	0.1	-0.4
Prospective memory result	0.2	0.3	0.5	-0.4	-0.5	-0.7	-0.6	-0.7	-0.5	0.6	-0.4	-0.4	-0.4
Lung cancer (father)	0.2	0.2	0.3	-0.4	-0.4	-0.3	-0.4	-0.6	-0.5	0.4	0.5	-0.6	0.2
Length of working week for main job	0.2	0.3	0.8	-0.3	-0.4	-0.6	-0.6	-0.6	-0.1	0.1	-0.9	-0.3	-0.7
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.3	0.1	0.0	-0.3	-0.2	-0.2	0.2	-1.1	-0.9	0.0	-0.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	-0.4	-0.5	-0.2	-0.3	-0.3	-0.6	-0.6	0.1	-0.6	-0.4
Medication: Amlodipine	0.2	0.2	0.6	-0.3	-0.4	-0.8	-0.8	0.2	-0.2	0.2	-0.6	-0.3	-0.7
Birth weight	0.2	0.5	3.4	-0.3	-0.3	-0.2	-0.1	-0.3	-0.4	1.8	0.8	-0.3	0.1
Qualifications: College or University degree	0.2	0.5	1.3	0.5	0.6	0.5	0.7	1.1	0.7	-1.2	-0.3	0.6	0.5
Emphysema/chronic bronchitis	0.2	0.2	1.4	-0.3	-0.2	0.2	0.4	-0.1	-0.6	0.1	1.2	-0.3	-0.2
Medication: Ibuprofen	0.2	0.2	0.9	-0.3	-0.3	-0.2	-0.3	-0.5	-0.4	-1.0	0.4	-0.5	-0.5
Leg fat mass (right)	0.2	0.8	2.2	-0.9	-0.8	-0.9	-0.9	-1.5	-0.6	0.9	-0.1	-0.7	-0.9
Pulse rate, automated reading	0.2	0.7	2.9	0.4	0.6	0.7	0.7	0.6	0.5	1.7	0.8	0.7	1.0
Family relationship satisfaction	0.2	0.3	0.5	0.3	0.4	0.7	0.7	0.7	0.3	0.3	0.5	0.6	-0.1
Loneliness, isolation	0.2	0.2	0.5	-0.1	0.2	0.4	0.7	0.4	0.0	0.7	0.6	0.4	0.6
Friendships satisfaction	0.2	0.3	1.9	-0.2	-0.1	0.3	0.6	0.5	-0.4	0.4	1.4	0.0	0.4
Commuting to job workplace: Walk	0.2	0.2	0.4	0.2	0.4	0.6	0.6	0.4	0.3	0.2	0.5	0.4	0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	1.0	0.3	0.3	0.5	0.3	0.8	0.1	-0.1	1.0	0.3	0.5
Average weekly champagne plus white wine intake	0.2	0.3	1.2	-0.5	-0.4	-0.1	-0.3	0.3	-0.5	0.5	0.5	-0.4	-1.1
Financial situation satisfaction	0.2	0.2	1.3	0.1	0.1	0.3	0.4	0.3	-0.1	0.3	1.1	0.2	0.3
Medication: Paracetamol	0.2	0.3	0.5	0.4	0.5	0.6	0.7	-0.2	0.5	-0.6	0.6	0.6	-0.0
Diastolic blood pressure, automated reading	0.2	0.8	2.8	0.1	0.3	0.8	1.0	0.7	0.0	1.7	1.1	0.3	1.1
Ever depressed for a whole week	0.2	0.3	1.9	-0.0	-0.2	-0.4	-0.7	0.4	0.1	-0.4	-0.4	-0.1	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.0	-0.0	0.2	0.4	0.7	0.0	-0.0	0.8	0.7	0.2	1.0
Supplements: Calcium	0.2	0.2	0.8	-0.4	-0.3	-0.1	0.1	0.0	-0.6	0.9	0.5	-0.6	0.3
Leg fat mass (left)	0.2	0.9	2.6	-0.9	-0.9	-1.0	-1.0	-1.6	-0.6	0.7	-0.3	-0.7	-1.0
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.5	-0.0	0.2	0.4	0.6	0.7	0.0	0.1	0.5	0.3	0.4
Neuroticism (Nagel 2018)	0.1	0.3	0.9	0.1	0.2	0.4	0.9	0.2	0.1	0.7	0.9	0.5	0.5
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	-0.1	-0.1	-0.3	-0.1	0.2	0.1	-0.4	-0.4	0.0	-0.6
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	-0.0	0.1	0.5	0.6	0.6	0.1	-0.4	0.5	0.3	0.6
Breast Cancer	0.1	0.2	0.5	-0.4	-0.5	-0.6	-0.5	-0.5	-0.4	0.4	0.1	-0.5	-0.7
Body Mass Index (BMI) (2010)	0.1	0.2	1.2	0.4	0.3	0.3	0.4	1.1	0.3	0.2	-0.0	0.4	-0.1
Blood Eosinophil Count	0.1	0.4	2.2	0.0	0.1	-0.1	-0.0	0.4	0.6	-1.5	-1.2	0.4	-0.1
Waist Hip Ratio (WHR)	0.1	0.3	2.0	0.2	0.1	0.2	0.3	-1.4	0.2	-0.7	0.2	0.2	0.1
Hypothyroidism (self reported)	0.1	0.1	1.0	-0.1	-0.1	-0.2	-0.2	-0.4	0.0	-1.0	-0.3	-0.1	-0.1
Number of treatments/medications taken	0.1	0.3	1.2	-0.4	-0.2	-0.0	0.1	-0.1	-0.3	1.1	1.0	-0.1	0.3
Sensitivity / hurt feelings	0.1	0.1	0.2	-0.2	-0.3	-0.4	-0.2	-0.4	-0.2	0.3	-0.4	-0.1	-0.4
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.6	-0.3	-0.2	-0.1	-0.1	-0.6	-0.2	0.8	0.3	0.1	-0.1
Relative age of first facial hair	0.1	0.2	0.4	0.6	0.5	0.4	0.7	0.6	0.4	-0.2	-0.3	0.5	0.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.4	-0.6	-0.4	-0.4	-0.2	0.2	-0.3	-0.6	0.3	-0.3	0.1
Medication: Metformin	0.1	0.2	0.9	0.0	-0.0	-0.2	-0.3	-0.1	0.2	-0.3	-1.0	0.1	-0.6
Townsend deprivation index at recruitment	0.1	0.1	0.4	-0.1	-0.1	-0.1	-0.0	-0.6	-0.2	0.7	0.5	-0.0	0.4
Multivitamins +/- minerals	0.1	0.1	0.6	-0.0	0.0	0.1	0.3	0.6	-0.1	0.8	0.2	-0.0	0.5
Medication: Atenolol	0.1	0.1	0.4	-0.0	0.2	0.3	0.1	0.3	0.1	0.4	0.7	0.3	0.6
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	0.0	0.1	0.0	0.4	0.2	0.1	-0.1	-0.0	0.2	0.6
Past tobacco smoking	0.1	0.3	0.7	0.4	0.4	0.5	0.3	0.8	0.3	0.4	-0.6	0.1	0.8
Alcohol usually taken with meals	0.1	0.2	0.6	-0.4	-0.3	-0.2	-0.2	-0.4	-0.3	-0.3	0.3	-0.3	-0.8
Fluid intelligence score	0.1	0.1	0.6	-0.2	-0.0	0.2	0.3	0.5	-0.2	0.2	0.8	-0.1	0.2
Impedance of arm (right)	0.1	0.5	3.4	-0.2	-0.3	-0.3	-0.7	-0.0	-0.3	-1.9	0.2	-0.4	-0.4
Worrier / anxious feelings	0.1	0.1	0.5	0.1	0.2	0.5	0.7	-0.1	0.1	-0.1	0.6	0.3	0.2
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	0.4	0.5	0.3	0.2	0.3	0.5	0.4	-0.1	0.5	-0.0
Noisy workplace	0.1	0.2	1.0	-0.0	0.0	0.2	0.2	0.2	-0.1	1.0	0.6	0.0	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.6	0.2	0.2	0.3	0.5	0.2	0.0	-0.8	0.4	0.1	-0.2
Arm fat mass (right)	0.1	0.3	0.9	-0.4	-0.4	-0.6	-0.5	-0.9	-0.2	0.1	-0.4	-0.3	-0.8
Hair/balding pattern: Pattern 4	0.1	0.3	1.1	-0.1	-0.1	0.4	0.3	0.6	-0.5	0.7	1.1	-0.2	0.6
Birth weight of first child	0.1	0.3	1.5	-0.1	-0.1	0.0	0.4	-0.5	-0.2	1.2	0.6	-0.1	-0.3
Peak expiratory flow (PEF)	0.1	0.3	1.4	-0.2	-0.3	-0.3	-0.3	-0.6	-0.3	1.2	0.4	-0.4	-0.6
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.8	0.1	0.0	0.1	-0.1	-0.2	0.3	-0.9	-0.5	0.3	-0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.8	-0.6	-0.5	-0.2	-0.3	-0.5	-0.7	0.3	0.9	-0.6	0.0
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.4	0.0	0.1	0.2	0.2	0.4	-0.0	0.5	0.6	0.2	0.4
Body fat percentage	0.1	0.5	1.0	-0.4	-0.5	-0.8	-0.9	-1.0	-0.1	-0.7	-0.8	-0.3	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.1	0.0	0.2	0.3	0.1	0.0	0.5	0.6	0.2	-0.3
Medication for pain relief, constipation, heartburn	0.1	0.1	0.4	-0.1	-0.2	-0.2	-0.5	0.1	-0.0	-0.6	-0.6	-0.2	-0.1
Medication: Allopurinol	0.1	0.1	0.4	-0.1	0.0	-0.0	0.1	-0.0	0.0	0.6	0.6	0.1	-0.4
Alcohol intake frequency.	0.1	0.2	0.4	-0.4	-0.4	-0.5	-0.2	-0.6	-0.6	0.3	0.5	-0.4	-0.7
Chest pain or discomfort	0.1	0.2	0.8	0.4	0.4	0.2	0.4	0.4	0.4	-0.9	-0.3	0.4	0.5
Leg pain on walking	0.1	0.1	0.3	0.3	0.3	0.3	0.4	0.1	0.5	0.2	-0.3	0.6	0.2
Medication: Aspirin	0.1	0.1	0.5	-0.1	-0.0	-0.3	-0.1	0.2	0.2	0.6	-0.7	0.2	-0.6
Long-standing illness, disability or infirmity	0.1	0.1	0.4	-0.5	-0.4	-0.4	-0.3	-0.6	-0.2	-0.1	-0.0	-0.1	0.3
Ever had bowel cancer screening	0.1	0.2	0.6	0.3	0.4	0.4	0.2	0.2	0.2	0.5	0.3	0.3	0.8
Breast cancer (self-reported)	0.1	0.2	1.0	0.3	0.3	0.2	0.5	0.3	0.1	-0.4	0.1	0.2	1.0
Medication: Aspirin	0.1	0.2	0.9	-0.3	-0.2	-0.4	-0.2	0.1	-0.1	1.0	-0.3	-0.0	-0.4
Illnesses of father: None of the above (group 1)	0.1	0.1	0.6	-0.4	-0.3	-0.1	-0.1	-0.5	-0.4	0.2	0.8	-0.4	-0.2
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	-0.5	-0.4	-0.2	0.0	-0.7	-0.4	0.5	0.2	-0.3	0.3
Medication: Blood pressure	0.1	0.3	1.4	-0.1	-0.1	-0.3	-0.1	-0.3	0.3	0.7	-1.2	0.2	-0.6
High cholesterol (Self-reported)	0.1	0.2	1.0	0.2	0.3	0.5	0.3	0.6	0.2	0.0	0.4	0.3	1.0
Medication: Bendroflumethiazide	0.1	0.1	0.2	0.4	0.4	0.3	0.2	0.3	0.4	0.3	-0.4	0.4	0.4
Ever smoked	0.1	0.2	0.8	-0.1	-0.1	-0.0	0.1	-0.8	-0.2	-0.6	0.9	0.0	-0.3
Leg fat percentage (left)	0.1	0.3	0.8	0.5	0.6	0.6	0.6	0.1	0.5	-0.0	0.2	0.6	0.9
Number of operations (self-reported)	0.1	0.1	0.2	0.2	0.2	0.3	0.2	-0.1	0.2	-0.5	0.3	0.2	0.4
Irritability	0.1	0.1	0.7	0.1	0.2	0.1	0.2	-0.0	0.1	0.8	0.4	0.4	-0.3
Cholesterol lowering medication	0.1	0.1	0.8	-0.2	-0.1	0.1	0.1	-0.2	-0.1	0.9	0.3	0.0	0.2
Alzheimer’s Disease (in father)	0.0	0.0	0.1	-0.1	-0.1	0.0	-0.1	-0.3	0.0	0.2	0.0	0.1	-0.2
Crohns Disease (2017)	0.0	0.1	0.5	-0.1	0.1	0.4	0.4	0.7	0.1	-0.2	0.3	0.0	0.1
Coronary Artery Disease (CAD)	0.0	0.1	0.2	-0.0	0.0	0.2	-0.0	-0.1	0.1	0.3	0.2	-0.4	0.4
Lung FVC	0.0	0.2	1.3	0.1	0.3	0.6	0.4	0.2	0.3	1.2	0.2	0.3	0.2
Hair Pigment	0.0	0.4	0.7	0.4	0.6	0.8	0.8	0.8	0.7	-0.6	-0.3	0.8	0.5
Tanning	0.0	0.3	1.3	0.5	0.6	0.6	0.8	0.2	0.2	-0.1	0.4	0.3	1.2
Fed-up feelings	0.0	0.0	0.1	0.2	0.1	0.0	0.3	-0.1	0.2	0.3	-0.2	0.4	0.0
Leg fat percentage (right)	0.0	0.1	0.5	0.2	0.3	0.4	0.4	-0.2	0.3	0.2	0.3	0.4	0.7
Average weekly red wine intake	0.0	0.0	0.2	-0.1	-0.1	-0.1	0.0	-0.2	0.1	-0.2	-0.4	0.0	-0.4
Arm fat mass (left)	0.0	0.2	0.7	-0.3	-0.3	-0.5	-0.5	-0.9	-0.1	0.1	-0.5	-0.2	-0.6
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.0	-0.1	0.0	0.1	-0.2	-0.1	0.1	0.0	0.0	0.1	0.2
Age started oral contraceptive pill	0.0	0.0	0.1	0.0	0.1	0.1	0.1	-0.2	-0.0	-0.2	0.3	-0.1	0.1

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