Hub : Genes

PLCD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0720 0.0320 2.5e-03 0.021 0.009 0.020 0.013 0.025 1.2e-03 2.7e-02 1.3e-03 7.9e-03 4.2e-04
2 GTEx Brain Cerebellar Hemisphere 0.3280 0.1160 7.3e-03 -0.009 NA 0.011 NA -0.007 6.1e-01 NA 1.6e-01 NA 5.4e-01
3 GTEx Colon Transverse 0.1960 0.0700 3.6e-03 0.078 NA 0.074 NA 0.083 1.5e-04 NA 2.1e-04 NA 9.3e-05
4 GTEx Skin Not Sun Exposed Suprapubic 0.1080 0.0440 4.0e-03 0.101 NA 0.059 NA 0.067 3.7e-06 NA 3.8e-04 NA 1.5e-04
5 ROSMAP Brain Pre-frontal Cortex 0.1318 0.0320 8.8e-11 0.115 0.102 0.101 0.118 0.110 1.3e-14 4.7e-13 7.1e-13 6.6e-15 5.0e-14
6 YFS Blood 0.0689 0.0155 0.0e+00 0.075 0.072 0.080 0.079 0.079 2.0e-23 1.6e-22 8.0e-25 1.1e-24 1.7e-24
7 TCGA Breast Invasive Carcinoma 0.0127 0.0073 2.0e-03 0.017 0.008 0.005 NA 0.006 1.9e-04 7.3e-03 2.6e-02 NA 1.5e-02
8 TCGA Prostate Adenocarcinoma 0.0523 0.0240 1.8e-05 0.041 0.037 0.039 NA 0.033 3.9e-05 8.8e-05 6.3e-05 NA 2.0e-04
9 TCGA Thyroid Carcinoma 0.3540 0.0880 4.4e-07 0.020 0.086 0.092 NA 0.082 3.9e-03 1.1e-08 2.8e-09 NA 2.3e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 1.2 1.9 4.4 -1.0 -1.5 -1.8 2.1 1.1 -1.2 -1.2 -1.4 -0.6
Bipolar Disorder or Schizophrenia 1.5 3.7 13.2 -1.1 -1.3 -1.8 3.6 0.5 -1.6 -1.3 -1.8 -2.5
Depressed Affect (Nagel 2018) 0.7 1.5 4.9 -2.2 0.4 0.1 0.5 1.5 -1.5 -1.1 -1.5 -0.8
Depression (Nagel 2018) 0.9 1.3 3.5 -1.9 0.1 -1.7 1.3 1.2 -1.1 -0.5 -1.0 0.5
Intelligence (Savage-Jansen 2018) 0.3 0.9 4.2 0.6 -0.9 -0.6 0.5 0.7 -0.8 -0.3 -0.9 2.0
Neuroticism (Nagel 2018) 0.4 0.9 1.9 -0.9 0.8 -0.2 1.2 0.8 -0.8 -0.6 -1.0 -1.4
Schizophrenia (2018) 1.1 2.3 8.9 -0.6 -0.4 -0.9 3.0 -0.2 -1.1 -0.7 -1.2 -2.7
Schizophrenia vs Biploar Disorder 0.2 0.3 0.9 0.9 0.5 1.0 0.4 -0.4 0.4 -0.1 0.3 -0.0
Worry (Nagel 2018) 0.6 1.2 4.4 0.7 1.4 -0.1 2.1 -1.0 0.7 1.0 0.4 -1.1
Alzheimer’s Disease (in mother) 1.4 1.6 4.8 -0.6 -1.5 -2.2 1.3 1.0 -1.0 -0.6 -1.2 -1.3
Alzheimer’s Disease (in father) 0.1 0.1 0.4 0.5 -0.3 -0.7 -0.6 -0.0 0.1 0.4 -0.1 0.3
Alzheimer’s Disease (including proxy) 0.6 0.9 4.6 1.2 -1.2 -2.2 0.4 -0.0 0.4 0.7 -0.0 -0.2
Crohns Disease (2017) 0.0 0.1 0.3 -0.2 -0.2 -0.4 0.3 0.5 -0.2 -0.5 -0.2 -0.2
Irritable Bowel Disease (IBD) 0.2 0.5 1.2 -0.6 -0.1 -0.6 0.2 1.0 -1.1 -0.8 -1.1 -0.2
Ulcerative Colitis (UC) 0.5 0.9 2.2 -0.7 -0.3 -0.9 0.7 1.1 -1.5 -0.8 -1.4 0.4
Major Depression (MDD) 0.9 1.1 5.2 -0.7 -1.2 -0.4 1.1 -0.6 0.7 0.6 0.4 -2.3
Reaction Time 1.0 2.0 3.8 -1.4 -1.4 -0.1 0.1 2.0 -1.9 -1.9 -1.7 0.0
Verbal and Numeric Reasoning (VNR) 0.2 0.4 1.6 -0.2 -0.4 -1.3 -0.1 0.8 -0.6 -0.4 -0.9 0.4
Breast Cancer 0.4 1.1 3.4 1.0 -1.4 -1.4 1.8 -0.5 0.3 0.6 0.4 0.6
Ovarian Cancer 1.7 2.2 8.3 -1.5 -1.9 0.7 1.3 0.9 -1.3 -0.7 -0.8 2.9
Prostate Cancer 0.6 0.8 1.9 -1.4 -1.2 -0.4 0.3 1.2 -0.8 -1.0 -0.8 -0.3
Age at First Birth 1.9 2.8 5.6 -2.0 -1.3 -1.1 -0.7 2.4 -1.7 -1.9 -2.3 -0.2
Bipolar Disorder (2011) 1.8 1.8 5.7 -0.9 -0.9 -1.4 2.4 1.0 -1.3 -1.2 -1.6 -0.2
Body Mass Index (BMI) (2010) 0.4 0.6 1.6 1.1 -0.4 1.1 -1.3 0.1 -0.3 -0.7 -0.5 -0.4
Coronary Artery Disease (CAD) 0.8 0.9 2.6 -1.0 1.1 -1.2 -1.3 0.4 0.4 -0.2 -0.1 -1.6
Crohns Disease (2012) 0.6 0.9 2.3 1.2 -0.8 0.2 -0.4 -0.9 1.4 1.0 1.5 0.2
Mean Putamen Volume 0.4 0.4 1.1 1.0 0.3 -0.8 1.1 -0.3 0.2 0.7 0.6 -0.1
Fasting Glucose 0.7 0.8 1.7 1.0 -1.3 0.9 -0.8 -1.3 0.6 0.7 0.8 0.3
HbA1C 0.4 0.5 0.8 -0.9 -0.9 -0.7 -0.7 0.8 -0.4 -0.7 -0.5 0.4
HDL Cholesterol 0.5 0.9 4.5 -0.6 0.6 -1.0 -1.1 0.2 0.3 0.0 0.4 2.1
LDL Cholesterol 0.4 0.7 2.3 0.4 1.5 0.9 -0.6 -0.8 0.5 0.9 0.5 -0.7
Lupus 1.8 2.7 7.0 1.8 0.4 -0.4 1.0 -2.3 2.0 2.6 1.7 -0.5
Neuroticism (2016) 1.1 1.6 4.2 -1.6 -1.2 -0.1 2.1 1.0 -1.2 -0.8 -1.2 -1.3
Primary Biliary Cirrhosis 0.8 1.2 2.6 1.1 -0.6 -1.6 0.3 -1.3 1.1 1.3 1.3 -0.5
Rheumatoid Arthritis 0.1 0.2 0.8 -0.9 -0.4 0.2 0.3 0.2 -0.3 0.2 -0.4 -0.2
Schizophrenia (2014) 0.8 1.7 5.5 -0.2 0.1 -0.6 2.4 0.0 -1.2 -1.0 -1.3 -2.3
Triglycerides 0.6 1.0 2.9 -0.8 -1.7 -0.5 0.5 1.1 -1.1 -0.8 -1.2 -0.8
Type 2 Diabetes (T2D) (2012) 1.0 1.1 4.3 0.2 -2.1 -0.8 1.3 -0.8 0.9 0.8 1.0 0.5
Ulcerative Colitis 0.5 0.8 2.1 -0.6 0.5 0.3 1.2 0.5 -1.0 -0.4 -1.0 1.4
Blood Eosinophil Count 0.2 1.5 7.4 -1.2 -0.6 -1.6 1.2 -0.2 0.0 0.4 0.0 2.7
Blood Platelet Count 0.1 0.9 2.1 -0.7 -0.2 1.3 0.9 0.9 -0.8 -1.4 -0.5 1.3
Blood Red Count 0.7 6.8 12.0 3.5 2.5 2.0 0.2 -3.0 3.0 3.4 3.1 0.0
Blood White Count 0.7 5.2 10.9 2.4 0.6 0.5 0.1 -3.0 3.3 3.3 2.8 1.3
Heel T-Score 0.6 4.9 16.5 1.9 3.3 4.1 1.2 -2.5 1.3 1.2 1.3 -0.2
BMI 0.3 1.5 4.0 -0.4 2.0 1.6 -0.7 0.5 -1.4 -1.4 -1.3 -0.5
Height 4.3 82.7 153.8 10.1 3.3 -0.3 7.6 -11.9 12.4 11.5 12.0 1.7
Waist Hip Ratio (WHR) 0.7 3.0 11.9 0.7 2.7 2.4 3.5 -0.8 -0.7 -0.4 -0.2 -0.3
Systolic Blood Pressure 0.7 3.4 7.8 1.4 -0.4 1.6 -1.0 -2.5 2.8 1.8 2.6 -0.8
Smoking Status 0.4 0.9 2.5 0.7 1.6 0.4 0.3 -1.2 0.9 0.9 0.8 -1.1
Allergy or Eczema 0.7 1.9 3.0 1.6 1.4 0.2 -1.4 -1.4 1.7 1.7 1.4 0.9
Cardiovascular Disease 0.2 0.8 1.3 -0.1 0.6 1.2 0.2 -1.1 1.0 1.1 1.1 -0.7
Hypothyroidism (self reported) 0.9 2.1 12.4 0.7 1.3 -1.6 3.5 -0.4 0.3 0.3 0.4 1.0
Respiratory disease 0.2 0.6 2.3 0.2 -0.4 -0.5 -0.4 -0.5 0.4 1.0 0.8 1.5
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.7 0.9 0.8 0.7 -0.8 -0.3 1.3 0.5 1.1 0.3
Lung FEV1/FVC ratio 0.5 2.4 7.7 0.4 -0.4 2.4 1.6 -1.7 0.6 0.7 1.4 2.8
Lung FVC 0.5 2.8 10.8 1.1 3.3 2.8 -1.7 0.0 -0.8 -0.5 -0.3 -1.1
Neuroticism 0.5 1.1 2.1 -0.9 1.1 0.1 1.3 1.0 -1.3 -0.9 -1.4 -0.8
Chronotype (morning person) 0.4 0.8 5.5 0.9 -0.1 0.1 0.1 -0.3 0.5 0.6 0.7 -2.3
Hair Pigment 0.0 1.1 3.8 -1.2 0.3 1.2 2.0 0.5 -0.6 -0.9 -0.9 -0.7
Tanning 0.0 0.4 1.4 0.4 -0.2 -0.4 -0.2 0.4 -0.5 -0.8 -0.5 -1.2
Hand grip strength (left) 0.4 1.2 3.3 0.6 -0.0 0.7 -1.8 -1.4 1.6 1.0 0.9 -0.3
Number of treatments/medications taken 0.2 0.4 1.5 -0.4 1.0 0.4 1.2 0.1 -0.1 0.1 -0.1 0.6
Average weekly spirits intake 0.5 0.6 1.7 1.3 0.9 1.0 0.5 -0.7 0.6 0.4 0.4 0.3
Sensitivity / hurt feelings 0.3 0.5 2.0 0.8 1.3 -0.2 0.6 -0.3 0.1 0.1 0.1 -1.4
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.7 -0.7 0.3 -0.6 1.3 0.2 -0.1 0.3 -0.0 0.3
Hearing difficulty/problems: Yes 0.2 0.4 2.0 0.1 -1.4 -0.4 0.1 0.6 -0.2 -0.1 -0.3 -0.8
Relative age of first facial hair 0.2 0.4 0.9 -1.0 -0.1 -0.2 0.7 0.5 -0.9 -0.6 -0.6 -0.6
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.4 0.6 -1.1 -1.2 0.8 -0.2 0.2 0.2 0.2 0.1
Ever used hormone-replacement therapy (HRT) 1.8 2.3 4.5 1.9 -0.2 0.6 0.1 -1.8 1.9 1.9 2.1 1.3
Ever had hysterectomy (womb removed) 1.5 1.6 5.3 2.3 1.5 1.7 -0.9 -1.1 0.9 0.9 0.8 -0.5
Systolic blood pressure, automated reading 0.5 1.5 3.1 1.6 -0.1 1.1 -0.1 -1.8 1.2 1.3 1.6 -1.1
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 2.8 0.5 0.3 0.7 -0.9 -1.3 1.7 1.0 1.5 -1.6
Angina 0.9 1.2 2.6 1.1 0.5 0.6 -0.2 -1.5 1.4 1.3 1.6 -0.1
Medication for hormone replacement therapy 1.4 1.6 3.2 1.3 -0.5 1.1 1.3 -1.8 1.3 1.3 1.5 -0.6
Vitamin and mineral supplements 0.4 0.5 2.0 -0.9 0.5 -0.6 0.1 -0.4 0.6 0.2 0.6 -1.4
Supplements: Zinc 1.3 1.4 2.5 -1.4 -0.2 1.3 -0.2 1.3 -1.3 -1.6 -1.4 1.2
Medication: Co-codamol 0.6 0.7 4.7 -0.5 -0.3 -0.1 2.2 0.6 -0.5 -0.3 -0.5 0.1
Medication: Metformin 0.1 0.1 0.5 0.2 -0.1 0.1 0.2 -0.1 0.7 0.0 0.4 -0.3
Diabetes (father) 1.2 1.5 2.7 -1.2 1.3 1.3 -0.3 1.1 -1.6 -1.6 -1.5 0.1
Diabetes (mother) 1.7 2.2 5.3 2.0 1.2 1.3 0.9 -2.3 1.4 1.4 1.7 0.3
Severe depression (siblings) 1.5 1.6 4.9 1.3 1.3 1.0 -2.2 -0.7 1.1 0.7 1.0 1.5
Pack years adult smoking proportion 0.3 0.5 1.2 -0.2 -0.8 -0.5 -1.1 0.6 -0.7 -1.0 -0.7 0.2
Impedance of leg (right) 0.3 1.4 3.5 0.3 0.3 -1.4 -0.1 -0.3 1.9 1.6 1.5 1.6
Leg fat-free mass (left) 1.1 5.9 12.1 3.0 1.6 1.0 2.1 -3.5 2.9 2.6 2.8 -0.6
Trunk fat percentage 0.5 2.0 5.0 0.5 -0.0 -0.8 2.2 -1.2 1.8 1.5 1.8 1.4
Hand grip strength (right) 1.6 4.4 8.6 2.4 1.0 1.0 -1.6 -2.9 2.9 2.4 2.5 0.3
Townsend deprivation index at recruitment 0.3 0.5 1.9 0.3 -0.8 -1.4 0.0 0.2 0.2 -0.1 -0.4 -1.2
Current tobacco smoking 0.7 1.2 3.9 0.3 -1.6 -2.0 -1.5 0.0 0.8 0.8 0.2 -0.4
Average weekly fortified wine intake 1.1 1.3 3.9 -0.6 -1.7 -1.6 -0.7 0.7 -0.7 -0.4 -0.6 2.0
Maternal smoking around birth 2.5 3.6 8.1 2.7 0.7 0.1 0.5 -2.5 2.0 2.8 2.2 0.9
Fed-up feelings 0.1 0.1 0.5 0.0 -0.1 0.0 0.7 0.4 -0.4 -0.0 -0.2 -0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 2.2 -1.0 -0.8 -1.5 -0.1 1.0 -0.6 -0.3 -0.9 0.5
Relative age voice broke 1.6 2.4 8.1 -2.8 -0.1 0.8 -1.3 1.9 -1.5 -1.8 -1.4 0.3
Taking other prescription medications 0.8 1.3 6.6 -1.3 0.2 -0.2 0.4 1.4 -0.7 -0.3 -0.8 2.6
Age when periods started (menarche) 0.9 2.1 4.9 -1.4 -2.2 -1.2 -1.8 1.5 -0.5 -1.0 -0.8 -1.9
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.3 0.0 -0.2 0.5 -0.1 -1.3 1.5 0.8 1.4 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 4.6 0.6 0.2 2.1 0.3 -0.9 0.6 0.1 0.6 -0.1
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 4.8 -0.7 -2.2 -1.0 -1.6 1.1 -0.4 -0.3 -0.4 0.1
Qualifications: CSEs or equivalent 0.6 0.8 2.1 -0.8 0.5 1.4 0.8 0.6 -0.8 -1.0 -0.8 -0.9
Serious illness, injury or assault to yourself 0.4 0.5 1.2 0.2 0.4 0.2 -0.3 -0.7 1.1 0.7 0.9 -1.1
High blood pressure 0.5 1.5 3.2 0.5 0.3 0.8 -0.1 -1.6 1.8 1.7 1.7 -1.0
Hayfever, allergic rhinitis or eczema 0.2 0.5 2.3 0.8 1.0 0.5 -1.5 -0.1 0.3 0.4 -0.2 0.0
Multivitamins +/- minerals 0.1 0.1 0.4 0.6 -0.6 0.2 -0.2 0.2 -0.2 -0.0 -0.4 0.4
Stomach or abdominal pain in last month 2.0 2.5 6.2 2.5 2.1 0.6 -0.2 -1.9 1.4 1.8 1.2 -1.1
Supplements: Glucosamine 1.2 1.6 3.2 -1.4 -0.1 1.0 -1.0 1.8 -1.1 -1.6 -1.3 1.2
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 0.6 -0.2 -0.5 0.5 -0.3 -0.3 0.8 0.8 0.7 0.1
Medication: Atenolol 0.8 0.9 3.2 -1.2 -0.1 0.2 -1.8 0.4 0.5 -0.1 -0.1 -1.8
Medication: Levothyroxine sodium 1.2 2.0 10.0 1.2 0.1 -1.1 3.2 -0.8 0.4 1.1 0.7 1.6
Sitting height 6.8 48.4 107.2 8.3 1.1 -1.4 0.7 -8.7 10.4 9.1 9.7 1.4
Chronic bronchitis/emphysema (father) 0.2 0.2 0.8 0.0 -0.5 -0.9 -0.1 0.5 -0.1 0.1 -0.1 0.9
High blood pressure (mother) 0.5 0.7 2.8 -0.3 1.3 1.7 0.2 -0.7 0.7 0.1 0.6 0.7
Body mass index (BMI) 0.2 0.8 1.7 -0.9 0.6 0.9 -0.2 0.9 -1.3 -1.1 -1.1 -0.1
Impedance of leg (left) 0.2 1.1 2.8 0.1 0.1 -1.4 0.1 -0.2 1.7 1.3 1.2 1.4
Leg predicted mass (left) 1.1 6.1 12.4 3.1 1.6 1.1 2.2 -3.5 3.0 2.6 2.9 -0.7
Trunk fat mass 0.9 4.0 7.6 1.8 1.0 -0.2 2.1 -2.4 2.8 2.4 2.6 1.0
Waist circumference 0.3 1.3 2.9 0.8 1.7 1.3 1.1 -1.3 0.9 0.9 1.1 0.6
Number of incorrect matches in round 0.8 1.3 3.1 1.8 0.7 1.2 0.1 -1.4 1.4 0.9 1.2 -0.1
Past tobacco smoking 0.7 1.3 6.9 -1.1 -2.6 -1.1 -0.8 0.9 -0.4 0.2 -0.5 0.6
Alcohol usually taken with meals 0.2 0.3 0.9 -0.1 0.9 0.8 -0.1 -0.3 0.4 -0.1 0.2 -0.8
Nervous feelings 1.1 2.0 4.4 -0.3 0.9 0.8 2.0 1.3 -2.0 -1.2 -2.1 -1.2
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 3.0 -1.2 1.2 1.1 -0.5 1.5 -1.3 -1.2 -1.7 -1.6
Hearing difficulty/problems with background noise 0.8 1.2 2.4 -0.6 -0.7 1.6 -1.2 1.1 -0.9 -1.2 -1.2 -1.1
Hair/balding pattern: Pattern 2 1.0 1.3 5.2 -0.7 -1.2 -0.6 2.3 0.7 -1.3 -0.8 -1.1 0.1
Had menopause 2.7 3.3 7.0 1.5 -0.8 -1.0 1.0 -2.4 2.2 2.4 2.6 1.3
Had other major operations 0.4 0.5 1.0 -0.1 1.0 -0.9 -0.8 0.8 -0.7 -0.1 -0.8 -0.2
Forced vital capacity (FVC) 1.8 6.9 13.2 3.1 3.6 1.9 0.8 -3.3 2.8 2.8 2.9 0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 2.9 0.6 0.3 1.7 -0.2 -0.5 0.5 0.2 0.2 0.2
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.0 -0.2 -0.6 -0.3 1.0 -0.8 0.7 0.1 0.6 0.6
Qualifications: None of the above 0.5 1.1 3.7 0.6 -0.1 0.2 1.9 -1.1 0.3 1.2 1.0 -1.6
Financial difficulties in last 2 years 0.4 0.5 2.6 0.1 0.7 1.0 -1.6 0.1 -0.5 -0.3 -0.4 -0.6
Mouth/teeth dental problems 0.9 1.4 5.7 -1.2 1.0 2.4 -1.0 0.9 -1.0 -0.7 -1.0 0.2
Heart attack 0.8 1.0 1.9 -1.3 -0.0 0.4 -1.4 1.1 -0.8 -0.6 -1.0 -1.3
Allergy 0.1 0.3 1.2 -0.4 -1.1 -0.6 0.3 0.2 0.1 -0.5 -0.0 -0.9
Pain all over the body in last month 0.6 0.6 3.2 -0.2 0.5 1.8 0.6 0.4 -0.5 -1.1 -0.6 0.2
Diabetes (self-reported) 0.2 0.3 0.7 0.4 0.3 0.2 -0.7 -0.4 0.9 0.4 0.7 -0.4
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.6 1.3 0.6 -0.1 0.3 -0.6 0.8 0.9 0.9 0.1
Medication: Ramipril 1.7 2.1 4.8 1.0 -0.1 -0.4 -0.9 -1.9 1.8 2.2 1.8 -1.5
Medication: Simvastatin 0.6 0.9 4.3 -1.0 0.1 1.2 -2.1 0.9 -0.3 -0.5 -0.2 -0.1
Fluid intelligence score 0.1 0.2 1.1 0.1 -0.3 -1.0 0.2 0.5 -0.3 -0.2 -0.5 0.2
Illnesses of siblings 1.3 1.8 7.7 -0.8 -0.7 -2.8 0.4 1.6 -1.2 -1.0 -1.4 0.5
Neuroticism score 0.4 0.8 2.8 -0.5 0.9 -0.3 1.7 0.7 -1.1 -0.6 -1.1 -0.5
Weight 1.0 4.9 9.1 2.6 1.9 0.8 1.7 -3.0 2.8 2.6 2.7 -0.0
Impedance of arm (right) 0.7 3.2 14.9 -0.6 -1.6 -2.7 3.9 0.4 0.8 0.6 0.8 1.5
Arm fat percentage (right) 0.3 1.1 2.3 -1.2 -0.2 -0.5 1.5 1.3 -1.1 -1.2 -1.0 0.6
Trunk fat-free mass 1.6 9.3 18.0 4.0 2.8 1.3 0.8 -4.2 3.9 3.6 3.3 -1.2
Hip circumference 0.3 1.4 3.6 1.0 0.6 -0.3 0.6 -1.3 1.9 1.5 1.6 0.8
Time employed in main current job 3.1 3.6 7.7 2.8 0.1 0.0 1.1 -2.6 2.0 2.3 1.9 -1.8
Alcohol intake versus 10 years previously 0.3 0.5 1.3 -0.8 -0.1 1.2 -0.8 0.5 -0.6 -1.0 -0.6 -0.4
Father’s age at death 0.5 0.7 1.6 0.6 -1.0 0.5 -0.5 -0.7 1.3 0.5 1.1 0.8
Worrier / anxious feelings 0.4 0.8 3.5 -0.5 1.0 -0.0 0.6 0.7 -0.4 -0.5 -0.9 -1.9
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 1.2 0.3 0.6 -0.8 -0.7 0.3 0.6 0.6 -0.2 -1.1
Falls in the last year 1.9 2.5 6.2 -1.9 0.3 -1.1 -1.0 2.5 -1.9 -1.6 -2.0 -0.6
Hair/balding pattern: Pattern 3 0.2 0.2 1.4 0.1 -0.0 1.2 -0.2 0.2 -0.4 -0.5 -0.4 -0.1
Number of live births 1.2 1.7 3.2 -1.4 -0.5 1.4 0.7 1.8 -1.7 -1.5 -1.4 -0.7
Forced expiratory volume in 1-second (FEV1) 1.4 4.6 7.8 2.6 2.8 2.5 1.0 -2.6 2.0 1.8 2.2 0.7
Pulse rate 1.3 2.3 11.3 -1.4 1.6 0.9 3.4 0.1 -1.2 -0.3 -1.0 0.9
Happiness 0.4 0.5 1.2 -0.3 0.8 0.6 -0.3 0.7 -1.1 -0.8 -0.9 -0.5
Noisy workplace 0.5 0.6 3.3 -0.9 -0.3 0.6 -0.4 0.1 -0.0 -0.3 0.1 -1.8
Qualifications: A levels/AS levels or equivalent 0.5 1.1 3.1 -0.8 -0.1 -1.8 -1.2 1.0 -1.1 -0.8 -1.3 0.1
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 3.0 -0.2 1.7 1.1 0.7 1.1 -0.7 -1.0 -0.9 0.2
Mouth/teeth dental problems: Dentures 0.3 0.6 1.8 0.1 -0.5 -1.3 0.8 -0.3 0.6 0.6 0.7 1.1
Asthma 0.3 0.6 1.7 0.3 0.1 0.1 0.2 -1.0 0.6 1.3 0.9 1.1
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 3.3 -0.4 -1.4 -1.8 0.2 1.0 -0.1 -0.5 -0.5 -1.0
Medication: Cholesterol lowering 0.4 0.6 1.8 -0.6 -0.6 1.0 -1.4 -0.5 0.7 0.4 0.6 0.5
Depression (self-reported) 0.5 0.6 1.8 -0.5 -0.8 0.4 -1.4 1.1 -0.2 -0.9 -0.4 0.5
Medication: Lansoprazole 0.4 0.5 1.2 -1.0 -0.1 1.0 0.3 -0.6 0.4 0.6 0.6 1.1
Prospective memory result 0.8 1.0 4.0 0.9 2.0 1.2 -0.2 -0.7 -0.1 0.9 0.7 1.1
Lung cancer (father) 0.2 0.2 1.3 1.1 -0.1 0.5 0.5 -0.2 0.2 0.2 0.2 -0.2
Illnesses of mother 0.6 0.7 2.9 0.1 -0.8 -0.9 0.0 0.5 -1.0 -0.3 -0.9 -1.7
Forced expiratory volume in 1-second (FEV1), Best measure 2.4 7.6 11.9 2.8 3.5 3.4 2.4 -3.4 2.2 2.0 2.9 1.8
Pulse wave Arterial Stiffness index 0.3 0.4 1.8 -0.7 1.0 -0.3 -0.1 0.2 0.1 -0.2 0.2 1.3
Impedance of arm (left) 0.9 3.9 16.6 -0.4 -1.6 -2.3 4.1 -0.5 1.7 1.4 1.9 1.6
Arm fat mass (right) 0.1 0.4 1.6 0.4 0.8 0.1 1.3 -0.5 0.6 0.3 0.5 0.3
Trunk predicted mass 1.6 9.4 17.9 4.0 2.9 1.2 0.8 -4.2 3.9 3.6 3.4 -1.2
Standing height 4.1 40.4 77.8 7.2 3.1 0.1 4.3 -8.4 8.8 8.1 8.3 0.5
Length of working week for main job 0.5 0.5 1.6 1.3 -0.3 0.1 0.4 -0.4 0.7 0.5 0.8 -1.0
Exposure to tobacco smoke at home 1.2 1.4 2.6 -0.1 -1.3 -0.8 -1.4 1.6 -1.2 -1.5 -1.3 -0.4
Breastfed as a baby 1.0 1.3 2.5 -1.2 0.4 -0.2 -1.2 1.6 -1.3 -1.1 -1.6 -0.9
Tense / ‘highly strung’ 0.5 0.9 2.5 1.6 -0.0 0.3 1.0 -1.3 0.7 1.4 0.6 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 2.4 -0.3 -0.3 0.7 1.5 0.6 -1.0 -0.7 -0.9 0.8
Hair/balding pattern: Pattern 4 0.2 0.4 1.7 -0.9 -1.3 0.2 0.6 0.5 -0.2 0.1 -0.0 -0.3
Birth weight of first child 0.9 1.6 7.1 0.8 1.4 1.5 -1.5 -0.2 -0.3 -0.3 -0.1 -2.7
Peak expiratory flow (PEF) 0.4 0.9 3.0 1.6 1.7 1.3 0.4 -0.6 0.4 0.2 0.5 -0.0
Pulse wave reflection index 0.6 0.7 2.5 -0.1 -0.7 -1.6 -0.8 -0.1 1.3 0.3 1.0 0.2
Ever highly irritable/argumentative for 2 days 0.2 0.2 1.4 0.3 -0.7 0.3 1.2 0.1 0.3 -0.2 0.2 -0.0
Loud music exposure frequency 0.9 1.0 2.8 -0.9 -0.2 -0.2 0.0 1.7 -1.2 -1.6 -1.1 0.3
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 3.2 -0.8 -0.1 -1.3 -0.5 0.1 0.4 0.1 0.2 1.8
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.6 1.0 -0.2 -1.3 0.4 -0.7 0.5 0.2 0.4 -1.3
Blood clot in the leg (DVT) 1.0 1.3 6.4 -0.7 1.1 -0.5 0.4 0.7 -1.3 -0.1 -0.9 2.5
Medication: Paracetamol 0.4 0.7 1.2 -0.4 0.8 1.0 1.1 0.6 -1.1 -1.1 -0.8 -0.1
Headache pain in last month 0.3 0.5 4.2 0.2 0.0 -2.1 0.2 0.6 0.0 0.0 -0.4 0.2
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 2.7 -0.2 0.1 -0.2 0.6 1.6 -1.3 -1.4 -1.4 -0.6
Glaucoma (self-reported) 1.5 1.8 5.7 -1.3 -2.4 -1.0 0.2 0.6 -1.3 -1.4 -1.2 1.4
Gout (self-reported) 0.5 0.6 2.4 0.2 -0.3 1.6 1.5 0.0 -0.9 -0.2 -0.4 -0.1
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 6.9 1.2 0.8 -1.2 2.6 -0.4 0.2 0.5 0.4 0.2
Medication: Amlodipine 0.4 0.6 1.3 0.1 -0.6 0.7 0.2 -1.1 0.7 0.9 1.1 0.8
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.3 0.0 1.2 0.3 -0.4 0.9 -0.8 -0.1 -0.6 -0.1
Birth weight 0.3 0.6 1.9 1.2 0.4 0.8 1.4 -0.9 -0.2 0.4 0.0 -0.6
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.2 -0.9 -0.4 1.1 0.7 0.4 -0.4 -0.5 -0.4 -0.1
High blood pressure (siblings) 0.6 0.8 4.2 0.0 0.5 2.1 -0.3 -0.5 0.5 0.6 0.7 1.1
Forced vital capacity (FVC), Best measure 2.6 9.5 18.4 3.4 4.3 2.7 2.4 -3.8 2.9 2.7 3.3 1.2
Body fat percentage 0.2 0.8 2.2 0.3 0.3 -0.4 1.5 -0.5 0.9 0.8 1.0 1.3
Leg fat percentage (right) 0.1 0.3 1.3 -0.2 1.2 0.3 0.2 0.6 -0.3 -0.3 -0.3 0.8
Arm fat-free mass (right) 2.1 10.5 22.0 3.9 2.5 1.3 0.4 -4.7 4.2 4.0 3.9 -0.6
Exposure to tobacco smoke outside home 1.3 1.8 4.5 1.4 -1.2 0.1 -2.1 -1.3 1.5 1.3 1.6 0.6
Comparative body size at age 10 0.3 0.8 4.8 -0.3 0.1 -1.2 -0.6 -0.4 0.3 -0.1 0.4 2.2
Number of full brothers 0.9 1.1 3.8 -0.5 1.2 2.0 1.7 0.1 -0.7 -0.7 -0.5 -0.4
Worry too long after embarrassment 0.3 0.5 1.9 -0.3 0.1 -1.4 0.0 0.7 -0.8 -0.8 -1.0 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 3.7 -0.1 -0.1 0.6 1.9 -0.0 -0.0 -0.2 -0.3 0.3
Wheeze or whistling in the chest in last year 0.1 0.2 0.4 0.5 0.2 0.5 0.5 -0.6 0.4 0.4 0.4 -0.2
Number of children fathered 1.1 1.3 2.3 -1.4 -1.3 -0.2 -0.9 1.5 -1.3 -1.0 -1.3 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 2.4 2.8 5.4 1.8 1.4 0.2 0.2 -2.3 2.0 2.1 1.9 1.5
Age at first live birth 0.2 0.4 1.5 -1.2 -0.1 -0.5 -0.6 0.5 0.0 -1.1 -0.5 -0.5
Pulse wave peak to peak time 0.6 0.7 1.7 1.3 -0.7 0.2 0.4 -1.0 0.6 1.0 0.4 -1.2
Health satisfaction 1.0 1.3 2.4 -1.4 -0.4 0.7 0.6 1.3 -1.6 -1.4 -1.5 0.3
Shortness of breath walking on level ground 0.8 1.0 2.6 0.6 0.6 0.1 0.2 -1.2 1.4 1.6 1.4 0.3
Qualifications: College or University degree 0.1 0.3 0.9 -0.3 -0.1 -0.7 0.5 0.4 -0.4 -0.5 -0.7 0.9
Eye problems/disorders: None of the above 1.7 1.9 6.3 2.5 1.0 1.0 0.9 -1.8 0.7 1.4 1.0 -1.2
Mouth/teeth dental problems: Loose teeth 0.8 1.0 4.0 1.1 0.1 0.1 -0.7 -0.8 1.1 0.2 1.1 2.0
Emphysema/chronic bronchitis 0.6 0.7 2.0 -0.7 -1.4 -0.7 -0.6 0.6 -0.3 -0.5 -0.4 -1.4
Medication for pain relief, constipation, heartburn 0.2 0.4 1.4 -0.1 -0.5 -0.2 -0.8 -0.5 0.5 0.2 0.6 1.2
Neck or shoulder pain in last month 0.8 1.1 6.6 0.1 0.7 0.4 -0.8 1.0 -0.2 -0.6 -0.7 -2.6
Medication: Blood pressure 0.5 0.9 2.3 0.1 0.3 -0.5 -0.7 -1.4 1.3 1.5 1.3 0.2
Angina (self-reported) 0.9 1.2 2.3 1.3 0.4 0.8 -0.0 -1.4 1.4 1.3 1.5 -0.3
Migraine (self-reported) 0.6 0.8 1.5 -0.7 -1.1 -0.8 1.2 0.6 -0.8 -1.0 -0.8 0.7
Medication: Ibuprofen 0.6 0.8 3.7 0.1 -1.1 -1.9 -1.0 0.6 0.7 -0.0 0.2 0.1
Medication: Allopurinol 0.5 0.7 3.0 0.4 -0.2 1.7 1.2 -0.5 -0.3 -0.0 -0.1 -1.0
Medication: Omeprazole 0.4 0.5 1.5 -0.4 0.4 0.4 -0.9 1.2 -0.7 -0.5 -0.9 -0.3
Medication: Seretide 50 evohaler 0.8 1.0 2.2 0.0 0.2 0.4 -0.7 -0.9 1.2 1.5 1.2 1.5
Mean time to correctly identify matches 1.1 2.1 4.0 -1.5 -1.8 -0.3 -0.3 2.0 -1.6 -2.0 -1.6 0.1
Heart disease (mother) 1.1 1.4 8.3 0.3 0.3 -0.3 -0.7 -0.5 1.0 1.0 1.1 2.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 1.0 -0.0 -0.3 -1.0 -0.8 -0.0 0.6 0.6 0.5 -0.4
Whole body fat mass 0.6 2.3 4.0 1.6 1.3 0.2 1.5 -1.8 2.0 1.8 1.9 0.7
Leg fat mass (right) 0.2 1.0 2.9 1.1 1.7 0.9 0.5 -0.9 0.9 0.7 0.9 0.6
Arm predicted mass (right) 1.8 9.2 18.8 3.7 2.5 1.3 0.5 -4.3 3.9 3.7 3.6 -0.8
Pulse rate, automated reading 0.9 2.8 20.9 -0.3 0.8 -0.2 4.6 -0.5 -1.4 0.0 -0.9 0.9
Alcohol intake frequency. 0.3 0.7 3.7 -0.3 -1.2 0.7 0.1 0.4 0.1 -0.2 0.2 -1.9
Comparative height size at age 10 3.2 17.8 31.1 5.5 2.3 0.2 2.4 -5.6 5.6 5.3 5.3 -0.1
Number of full sisters 0.7 0.9 2.8 -0.4 -1.2 -0.6 -1.7 1.2 -0.6 -1.0 -0.7 0.0
Suffer from ‘nerves’ 0.5 0.9 1.7 -0.6 0.8 -0.2 1.2 1.1 -1.3 -1.0 -1.1 -0.4
Overall health rating 0.4 0.8 1.7 1.2 0.7 -1.0 0.8 -0.8 0.6 1.3 0.6 -0.6
Chest pain or discomfort 0.9 1.4 6.9 0.0 -1.2 -2.6 -1.0 0.6 -0.2 0.1 -0.3 1.5
Had major operations 0.3 0.4 1.2 -1.0 -1.1 0.4 -0.7 0.1 0.1 -0.1 0.3 -0.3
Age at last live birth 1.8 2.7 5.8 -2.3 0.0 0.9 -1.3 2.0 -1.6 -2.4 -1.9 -0.0
Family relationship satisfaction 0.5 0.6 1.3 -0.3 -0.5 0.7 0.2 0.7 -0.7 -0.9 -1.0 -1.2
Leg pain on walking 0.4 0.6 2.8 0.1 1.7 0.9 -0.0 0.1 -0.2 -0.2 -0.4 -1.1
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 2.9 1.3 1.7 1.0 -0.5 -1.1 1.2 1.3 0.8 0.7
Commuting to job workplace: Car/motor vehicle 0.3 0.4 0.8 -0.2 0.7 0.8 -0.1 -0.9 0.4 0.6 0.9 0.0
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 2.2 -0.4 -1.5 -1.1 -0.0 -0.3 0.6 0.6 0.9 1.4
Medication: Aspirin 0.2 0.3 1.2 -0.1 0.2 0.7 -1.1 0.1 0.4 0.3 0.1 -0.7
Supplements: Vitamin C 1.1 1.3 5.7 1.2 0.6 1.8 -0.9 -0.3 0.0 0.5 0.1 2.4
Knee pain experienced in last month 0.2 0.3 0.9 0.7 0.7 0.2 -0.7 0.2 -0.5 0.3 -0.4 -0.9
Hypertension (Self-reported) 0.7 1.9 4.0 0.5 0.4 0.9 0.1 -1.8 2.0 1.9 1.9 -1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 4.1 -2.0 -0.5 0.8 0.8 0.3 -0.8 -0.5 -0.4 0.7
Illnesses of father: Heart disease 0.7 0.9 3.3 -0.5 1.8 0.7 -0.8 0.6 -1.2 -0.3 -1.0 0.7
Illnesses of siblings: Diabetes 0.2 0.3 0.8 0.1 -0.7 0.6 0.2 -0.9 0.5 0.5 0.7 0.2
Smoking status: Previous 1.4 2.1 8.1 1.4 2.8 1.7 1.6 -1.5 0.6 0.3 1.1 0.3
Forced expiratory volume in 1-second (FEV1), predicted 2.4 5.0 11.4 3.4 1.0 0.5 1.6 -2.9 2.8 2.3 2.8 0.9
Whole body fat-free mass 1.4 8.0 16.3 3.6 2.4 1.2 1.3 -4.0 3.5 3.2 3.2 -1.0
Leg fat-free mass (right) 1.1 5.7 12.5 3.0 1.4 1.0 2.3 -3.5 2.8 2.5 2.7 -0.9
Arm fat percentage (left) 0.2 0.7 2.6 -1.1 -0.1 -0.0 1.6 0.9 -0.7 -0.9 -0.5 0.6
Average weekly red wine intake 0.4 0.6 2.5 1.6 0.9 0.6 -1.0 -0.3 0.5 -0.1 0.1 -0.0
Handedness (chirality/laterality): Left-handed 1.6 1.9 3.5 -1.8 -1.1 -1.1 0.8 1.5 -1.9 -1.7 -1.5 0.4
Mood swings 1.0 1.8 3.2 -1.0 0.8 1.3 1.0 1.1 -1.7 -1.3 -1.5 -1.8
Loneliness, isolation 0.3 0.4 0.9 -0.5 -0.5 -0.4 -0.3 0.9 -0.8 -0.3 -0.7 0.6
Long-standing illness, disability or infirmity 0.2 0.2 0.7 -0.1 0.3 -0.6 0.7 -0.2 0.3 0.5 0.3 0.9
Ever had bowel cancer screening 0.6 0.7 2.4 0.2 0.2 1.4 -1.5 0.8 -0.6 -0.4 -0.5 0.7
Diabetes diagnosed by doctor 0.2 0.4 1.4 0.6 0.2 -0.0 -0.2 -0.5 1.2 0.6 1.0 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 2.1 1.3 0.5 0.3 -0.0 -0.0 0.0 -0.2 -0.4 -1.5
Friendships satisfaction 0.4 0.5 1.3 0.0 -1.1 -0.9 0.3 0.6 -0.9 -0.3 -0.8 0.2
Qualifications: nursing, teaching 0.7 1.0 3.7 0.1 0.2 -0.5 -1.9 1.4 -1.1 -0.6 -1.2 0.5
Commuting to job workplace: Walk 0.4 0.5 2.5 -0.4 0.4 0.6 1.6 0.7 -0.6 -0.3 -0.5 0.2
Eye problems/disorders: Cataract 1.3 1.5 5.8 -2.4 0.6 0.5 -1.7 1.0 -0.1 -0.9 -0.1 1.5
Mouth/teeth dental problems: Mouth ulcers 0.9 1.5 6.3 0.8 -0.5 -0.3 2.5 -0.0 -0.4 -0.3 -0.4 -2.3
Medication for cholesterol 0.7 1.1 2.5 -0.8 -0.8 -1.6 -0.7 1.2 -1.0 -1.3 -1.2 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 1.5 0.7 -0.5 -0.2 -0.5 -0.5 0.7 1.2 0.7 0.2
Back pain experienced in last month 0.9 1.3 4.0 2.0 1.8 0.6 0.3 -0.8 0.8 1.2 0.6 -0.8
Mineral and other dietary supplements 0.9 1.2 3.5 0.5 -0.2 0.1 1.9 -1.3 1.2 1.0 1.4 -1.0
Breast cancer (self-reported) 0.5 0.6 2.2 -1.5 1.1 -0.6 -0.8 0.5 -0.5 -0.2 -0.4 -0.0
Asthma (self-reported) 0.3 0.6 1.8 0.5 -0.1 0.3 -0.0 -1.0 0.6 1.4 0.9 1.0
Osteoporosis (self-reported) 0.6 0.7 1.6 0.8 -0.6 -0.7 -0.3 -0.8 1.3 1.3 1.0 0.4
Osteoarthritis (self-reported) 2.5 3.3 8.2 -1.9 -0.2 -0.1 -0.4 2.9 -2.6 -2.2 -2.5 -0.4
Medication: Aspirin 0.2 0.2 0.8 0.1 -0.1 0.2 -0.9 0.2 0.6 0.5 0.2 -0.7
Medication: Gliclazide 1.3 1.5 9.5 -0.2 0.6 1.8 0.1 -0.4 0.5 -0.2 -0.1 -3.1
Illnesses of father: None of the above (group 1) 0.5 0.6 3.7 0.1 -0.7 -0.0 0.4 -0.0 0.5 -0.2 0.5 -1.9
Smoking status: Current 0.7 1.2 3.3 0.5 -1.4 -1.7 -1.8 0.1 0.7 0.7 -0.0 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 8.4 -0.6 1.0 2.9 -1.2 0.5 -1.0 -0.5 -0.3 2.0
Whole body water mass 1.4 7.9 15.8 3.6 2.4 1.2 1.3 -4.0 3.5 3.2 3.1 -1.1
Leg predicted mass (right) 1.1 5.9 12.4 3.1 1.5 1.1 2.2 -3.5 2.8 2.5 2.7 -1.0
Arm fat mass (left) 0.1 0.4 1.9 0.2 1.0 0.4 1.4 -0.4 0.4 0.2 0.5 0.2
Number of self-reported non-cancer illnesses 0.2 0.3 1.3 -0.3 1.1 0.7 0.2 0.3 -0.1 0.2 0.1 0.7
Average weekly champagne plus white wine intake 0.4 0.5 2.8 0.3 -0.6 -1.0 -0.2 -0.1 0.4 -0.1 -0.2 -1.7
Miserableness 0.7 1.1 2.4 -1.5 -0.3 -0.3 0.2 1.4 -1.5 -1.1 -1.4 -0.3
Guilty feelings 1.4 2.2 3.3 -1.5 1.1 0.5 1.5 1.4 -1.8 -1.7 -1.8 -1.4
Wears glasses or contact lenses 0.5 0.6 2.7 0.9 0.8 0.4 -0.0 -0.6 0.7 0.6 0.5 -1.6
Ever taken oral contraceptive pill 0.7 0.8 2.3 1.5 0.5 -0.0 0.2 -1.3 1.0 0.8 0.9 0.5
Hearing aid user 0.2 0.2 0.6 0.0 0.8 0.2 -0.8 0.1 0.1 0.5 0.3 0.4
Mother’s age at death 1.1 1.3 2.5 -1.5 -0.8 -0.1 0.7 1.0 -1.3 -1.4 -1.2 1.6
Financial situation satisfaction 0.2 0.3 1.5 -0.4 -0.5 -0.3 -0.2 0.4 -0.6 -0.3 -0.2 1.2
Tinnitus: Yes, now most or all of the time 1.0 1.2 4.6 -0.5 -0.8 -2.2 0.1 1.5 -0.9 -1.0 -0.9 0.2
Commuting to job workplace: Public transport 0.9 1.1 2.8 -0.1 -1.3 -1.7 0.2 1.2 -0.4 -0.9 -1.2 -1.0
Eye problems/disorders: Glaucoma 1.1 1.3 2.8 -1.7 -1.6 -0.2 0.3 0.9 -1.4 -1.4 -1.3 0.5
Medication: Blood pressure 0.5 0.9 5.6 -0.5 1.0 2.4 -0.2 0.2 0.3 -0.1 0.3 -0.9
Pain type(s) experienced in last month: Hip pain 1.5 1.9 5.2 2.3 1.3 1.1 -0.7 -1.1 1.4 1.5 1.2 -1.1
Supplements: Fish oil (including cod liver oil) 0.5 0.7 3.1 -0.2 0.2 0.3 -1.8 0.9 -0.8 -0.7 -1.0 0.4
High cholesterol (Self-reported) 0.3 0.5 0.8 -0.9 -0.8 -0.3 -0.9 0.7 -0.9 -0.2 -0.6 0.5
Medication: Bendroflumethiazide 0.7 1.0 4.0 -0.8 1.6 1.2 -0.2 0.5 -0.3 -0.5 -0.3 -2.0
Medication: Paracetamol 0.3 0.5 1.3 -0.1 1.1 1.0 0.7 0.6 -0.6 -0.8 -0.5 0.3
Medication: Lisinopril 0.2 0.3 1.1 -1.1 0.4 -0.3 0.7 -0.2 -0.3 -0.2 -0.0 0.8
Medication: Atorvastatin 4.2 5.2 10.0 1.8 -0.4 -0.3 -1.1 -3.0 3.2 3.1 3.0 2.3
Illnesses of father: High blood pressure 1.6 2.0 5.5 -0.8 0.6 2.0 -2.3 0.8 -1.3 -1.3 -1.1 1.7
Alcohol drinker status: Never 0.9 1.1 3.9 0.4 -0.3 1.0 0.0 -1.1 1.1 1.1 1.2 -2.0
Ever smoked 0.3 0.5 3.3 0.3 1.8 -0.2 -0.1 -0.1 0.2 -0.4 0.0 -1.0
Basal metabolic rate 1.3 7.5 14.8 3.5 2.3 1.1 1.4 -3.9 3.5 3.1 3.1 -0.8
Leg fat percentage (left) 0.1 0.4 0.8 -0.5 0.9 0.4 0.3 0.8 -0.6 -0.5 -0.6 0.6
Arm fat-free mass (left) 1.4 6.9 13.9 3.3 2.5 1.1 0.6 -3.7 3.3 3.1 2.9 -0.6
Number of operations (self-reported) 0.2 0.4 0.8 -0.7 0.8 0.9 -0.5 0.5 -0.5 -0.2 -0.2 0.6
Average weekly beer plus cider intake 0.9 1.3 2.4 1.1 0.2 -1.0 -1.5 -1.3 1.0 1.4 1.1 -1.0
Irritability 0.2 0.3 0.9 0.4 1.0 0.5 0.3 0.4 -0.2 -0.4 -0.4 -0.7
Risk taking 0.2 0.4 1.1 -0.1 0.5 -0.5 -1.0 0.2 0.6 0.5 0.2 1.0
Ever had prostate specific antigen (PSA) test 0.4 0.4 2.6 0.2 -0.6 0.1 -0.7 0.5 -0.1 0.3 -0.2 1.6
Fractured/broken bones in last 5 years 1.2 1.6 2.8 -1.6 1.1 1.2 -1.2 1.4 -0.8 -1.7 -1.3 -0.9
Age started oral contraceptive pill 0.2 0.3 0.9 0.5 0.7 0.2 -0.9 0.2 0.0 -0.2 -0.0 1.0
Diastolic blood pressure, automated reading 0.5 1.5 4.4 -0.5 0.7 0.9 1.8 0.5 -1.5 -0.8 -1.0 -2.1
Ever depressed for a whole week 0.6 0.8 3.6 0.1 -1.9 -0.8 1.2 -0.8 0.6 0.1 0.3 -0.5
Unable to work because of sickness or disability 0.8 1.0 2.6 0.8 -0.7 -0.6 -0.8 -1.2 1.4 0.9 1.6 0.7
Commuting to job workplace: Cycle 0.7 0.8 2.3 0.3 0.1 -0.7 -0.4 -1.1 1.5 1.0 1.4 -0.1
Myopia 0.9 1.3 2.3 -0.8 -1.5 -1.1 1.1 1.0 -1.2 -1.3 -1.3 -0.5
Vascular/heart problems diagnosed by doctor 0.5 1.4 2.9 -0.5 -0.4 -0.8 0.7 1.4 -1.7 -1.6 -1.6 1.1
Cholesterol lowering medication 0.2 0.2 1.1 -0.4 0.6 1.0 0.2 0.5 -0.4 0.1 -0.2 0.0
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.1 -0.1 0.5 0.5 -1.0 0.8 -0.7 -0.4 -0.6 -0.2
Pain experienced in last month 0.7 1.1 4.7 -0.3 -1.3 -0.9 -0.3 -0.8 0.7 0.7 1.1 2.2
Supplements: Calcium 0.3 0.3 1.1 0.1 -0.8 -0.8 -1.1 0.1 -0.3 0.2 -0.4 -0.1
Basal cell carcinoma (self-reported) 1.0 1.2 2.8 1.7 -0.7 -1.1 1.1 -0.6 1.1 1.3 0.9 0.8
Heart attack/myocardial infarction (self-reported) 0.7 0.9 2.5 -1.1 0.3 0.5 -1.2 0.9 -0.7 -0.4 -0.9 -1.6
Deep venous thrombosis (DVT) (self-reported) 1.5 2.0 6.9 -1.4 0.9 0.0 0.2 1.4 -1.9 -0.9 -1.5 2.6
Heart disease (siblings) 1.0 1.3 6.1 0.0 1.7 2.5 -0.4 -0.8 0.6 0.2 0.7 0.8
Alcohol drinker status: Previous 0.4 0.4 1.1 0.5 0.8 0.9 1.0 -0.1 0.0 0.0 -0.1 -1.1
Pack years of smoking 0.2 0.2 0.6 0.1 -0.6 -0.5 -0.8 0.2 -0.4 -0.6 -0.4 0.2
Impedance of whole body 0.6 3.1 6.5 -0.2 -1.1 -2.1 2.5 -0.6 2.1 1.7 2.0 2.0
Leg fat mass (left) 0.2 0.9 2.3 1.0 1.5 0.8 0.5 -1.0 1.0 0.8 1.0 0.6
Arm predicted mass (left) 1.3 6.6 12.7 3.4 2.3 0.6 0.2 -3.6 3.3 3.1 2.9 -0.8