Best TWAS P=5.45e-09 · Best GWAS P=1.56e-15 conditioned to 7.6e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Testis | PRSS50 | 0.23 | 0.09 | lasso | 10 | 0.15 | 3.3e-07 | 4.2 | -5.1 | 3.1e-07 | 0.17 | 0.35 | 0.45 | FALSE |
| 2 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SCAP | 0.05 | 0.01 | blup | 30 | 0.02 | 7.1e-03 | -8.0 | -5.4 | 6.1e-08 | 0.83 | 0.01 | 0.93 | TRUE |
| 3 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | PRSS45 | 0.09 | 0.08 | lasso | 1 | 0.06 | 4.6e-04 | 5.6 | 5.6 | 2.6e-08 | -0.14 | 0.00 | 0.96 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PRSS45 | 0.14 | 0.05 | lasso | 1 | 0.04 | 1.3e-05 | 5.6 | 5.6 | 2.6e-08 | -0.14 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PRSS45 | 0.18 | 0.08 | blup | 35 | 0.08 | 1.2e-09 | 5.6 | 5.8 | 5.4e-09 | -0.20 | 0.00 | 1.00 | TRUE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | PRSS45 | 0.37 | 0.10 | enet | 16 | 0.12 | 1.9e-14 | 5.6 | 5.8 | 5.8e-09 | -0.13 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PRSS45 | 0.05 | 0.06 | enet | 3 | 0.06 | 6.1e-07 | 5.6 | 5.7 | 1.1e-08 | -0.16 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | PRSS45 | 0.14 | 0.11 | lasso | 2 | 0.10 | 2.6e-07 | 5.6 | 5.5 | 3.2e-08 | -0.14 | 0.00 | 1.00 | FALSE |
| 9 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | PRSS45 | 0.27 | 0.00 | enet | 5 | 0.03 | 2.0e-02 | 4.9 | 5.3 | 1.2e-07 | -0.17 | 0.01 | 0.61 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PRSS45 | 0.11 | 0.04 | lasso | 1 | 0.04 | 5.2e-05 | 5.6 | 5.6 | 2.6e-08 | -0.14 | 0.00 | 0.99 | FALSE |