TWAS hub - PRSS50

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Left Ventricle	0.7242	0.0804	9.1e-04	-0.002	NA	-0.005	NA	-0.005	4.6e-01	NA	8.6e-01	NA	9.7e-01
2	GTEx	Nerve Tibial	0.8037	0.0490	3.2e-06	-0.003	NA	0.028	NA	0.050	6.8e-01	NA	4.3e-03	NA	1.8e-04
3	GTEx	Testis	0.2330	0.0730	4.1e-05	0.090	NA	0.128	NA	0.151	8.2e-05	NA	2.8e-06	NA	3.3e-07
4	METSIM	Adipose	0.0348	0.0157	2.8e-03	0.021	0.016	0.010	0.015	0.014	3.1e-04	0.0013	1.0e-02	0.0019	3.2e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	2	3	4
Mouth/teeth dental problems: Mouth ulcers	11.7	18.7	53.6	2.6	3.8	7.3
Medication: Aspirin	4.5	5.9	9.5	2.7	3.1	2.6
Medication: Amlodipine	4.4	6.2	13.0	1.0	-3.3	-3.6
Breast Cancer	4.1	9.9	25.0	2.1	-5.0	-3.2
Medication: Aspirin	3.6	4.8	11.4	3.4	2.1	1.8
Forced expiratory volume in 1-second (FEV1), predicted	3.1	6.4	14.1	0.7	-3.8	-3.4
Happiness	2.9	3.5	8.9	-0.4	-2.2	-3.0
Medication: Ibuprofen (e.g. Nurofen)	2.8	3.5	9.1	3.0	2.1	0.7
Lung cancer (father)	2.6	3.0	6.4	-0.6	2.5	2.3
Average weekly spirits intake	2.4	2.9	6.3	0.3	-2.5	-2.3
Comparative height size at age 10	2.4	13.1	26.2	2.3	-5.1	-4.5
Impedance of whole body	2.2	11.1	20.0	-3.4	-3.6	-4.5
Mouth/teeth dental problems	2.1	3.3	10.6	0.2	-1.6	-3.3
Exposure to tobacco smoke outside home	2.1	2.8	9.8	3.1	0.9	0.6
Angina (self-reported)	2.1	2.7	6.2	0.8	2.5	2.0
Number of full sisters	2.1	2.6	5.3	0.1	2.3	2.2
Osteoporosis (self-reported)	2.1	2.5	5.2	-1.4	-2.3	-1.8
Average weekly beer plus cider intake	2.1	3.0	4.4	1.9	2.0	2.1
Risk taking	2.1	3.1	5.2	-1.7	2.3	2.1
Impedance of leg (right)	2.0	9.5	22.6	-1.8	-3.5	-4.8
Impedance of leg (left)	2.0	9.8	21.1	-2.6	-3.4	-4.6
Impedance of arm (left)	2.0	9.2	13.3	-3.6	-3.3	-3.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	8.6	-2.9	-0.1	0.3
Irritable Bowel Disease (IBD)	1.8	4.3	11.3	-1.4	2.0	3.4
Medication: Lansoprazole	1.8	2.0	7.6	-2.8	0.6	-0.3
Angina	1.7	2.3	4.8	0.9	2.2	1.9
Pack years adult smoking proportion	1.6	2.4	6.6	1.1	2.6	1.4
Qualifications: CSEs or equivalent	1.6	2.1	4.6	1.4	2.2	1.4
Impedance of arm (right)	1.6	7.6	12.1	-2.9	-3.1	-3.5
Depression (self-reported)	1.6	1.9	5.2	1.1	1.1	2.3
Age at first live birth	1.6	2.9	5.7	2.4	-1.7	-1.7
Pack years of smoking	1.5	2.2	5.7	1.0	2.4	1.4
Ulcerative Colitis (UC)	1.4	2.6	6.8	-0.6	1.8	2.6
Lupus	1.4	2.1	4.3	-0.1	-2.1	-2.0
Medication: Ramipril	1.4	1.8	3.7	-0.4	1.9	1.8
Medication: Omeprazole	1.4	1.6	3.6	-0.9	-1.9	-1.4
Friendships satisfaction	1.4	1.7	4.9	-0.7	-1.2	-2.2
Crohns Disease (2017)	1.3	2.8	7.8	-1.4	1.3	2.8
Hand grip strength (right)	1.3	3.6	8.5	2.9	-1.8	-1.6
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	4.3	-1.0	-0.8	-2.1
Standing height	1.3	13.3	31.7	2.9	-5.6	-3.7
Exposure to tobacco smoke at home	1.3	1.4	4.0	2.0	-0.9	-0.9
Medication: Ibuprofen	1.3	1.6	5.2	2.3	1.1	0.1
Medication: Allopurinol	1.3	1.7	2.6	1.6	-1.4	-1.5
Heart disease (mother)	1.3	1.6	3.3	-1.8	1.6	0.5
Knee pain experienced in last month	1.3	2.0	6.0	0.2	2.5	1.4
Medication: Gliclazide	1.3	1.5	5.7	-2.4	-0.1	-0.6
Arm fat-free mass (left)	1.3	6.6	25.2	5.0	-0.4	0.9
Age at First Birth	1.2	1.7	4.0	-0.1	-2.0	-1.7
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	3.0	-1.6	1.0	1.7
Medication: Levothyroxine sodium	1.2	2.0	6.8	2.6	-0.7	0.9
Body mass index (BMI)	1.2	4.9	10.3	3.2	1.4	2.7
Pulse wave reflection index	1.2	1.5	4.0	2.0	0.4	1.4
Blood clot in the leg (DVT)	1.2	1.5	4.0	-0.1	2.0	1.5
Chest pain or discomfort	1.2	1.7	5.2	-0.6	2.3	1.1
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	5.1	-2.3	-0.8	-0.4
Ever had bowel cancer screening	1.2	1.4	4.1	-2.0	-0.8	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	7.7	-2.8	-0.7	-1.5
Arm predicted mass (left)	1.2	6.2	23.9	4.9	-0.3	1.0
Bipolar Disorder (2018)	1.1	1.8	2.8	1.4	1.6	1.7
Hip circumference	1.1	4.7	15.3	3.9	-1.6	1.1
Arm fat-free mass (right)	1.1	5.7	21.4	4.6	-0.8	0.8
Medication for pain relief, constipation, heartburn	1.1	2.0	6.4	-2.5	-1.2	-0.1
Arm predicted mass (right)	1.1	5.7	21.7	4.7	-0.3	1.0
Age at last live birth	1.1	1.6	4.8	2.2	-1.2	-0.1
Whole body water mass	1.1	6.2	23.0	4.8	-0.6	1.2
Tinnitus: Yes, now most or all of the time	1.1	1.2	4.9	-0.1	2.2	-0.0
Medication: Atorvastatin	1.1	1.4	5.0	2.2	0.0	0.8
Basal metabolic rate	1.1	6.0	22.0	4.7	-0.8	1.1
Schizophrenia vs Biploar Disorder	1.0	1.3	2.7	0.8	-1.6	-1.3
HbA1C	1.0	1.1	2.7	0.4	1.7	1.2
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.4	-1.5	-0.0	-1.5
Leg fat-free mass (left)	1.0	5.3	18.3	4.3	-0.4	1.6
Leg predicted mass (left)	1.0	5.3	18.6	4.3	-0.4	1.6
Weight	1.0	5.0	17.7	4.2	-1.2	1.0
Trunk fat-free mass	1.0	5.7	21.4	4.6	-0.9	0.6
Trunk predicted mass	1.0	5.6	21.1	4.6	-0.9	0.5
Number of full brothers	1.0	1.3	3.6	1.9	0.5	1.1
Whole body fat-free mass	1.0	6.0	22.1	4.7	-0.5	1.3
Eye problems/disorders: Cataract	1.0	1.1	2.1	-1.3	0.9	1.5
Commuting to job workplace: Public transport	1.0	1.2	3.3	1.2	-1.8	0.5
Number of operations (self-reported)	1.0	1.5	5.2	2.3	-0.6	0.6
Diastolic blood pressure, automated reading	1.0	3.0	11.4	3.4	-0.5	0.6
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	3.6	0.1	1.9	1.2
Alzheimer’s Disease (in father)	0.9	1.0	2.7	0.3	-1.6	-1.1
Height	0.9	17.0	41.6	3.3	-6.5	-3.9
Cardiovascular Disease	0.9	2.8	10.2	3.2	0.3	1.0
Lung FEV1/FVC ratio	0.9	4.7	13.9	-0.1	-2.2	-3.7
Hand grip strength (left)	0.9	2.5	8.8	3.0	-1.0	-0.3
Falls in the last year	0.9	1.2	2.0	-1.4	-1.1	-1.2
Noisy workplace	0.9	1.2	2.0	-1.4	-1.0	-1.3
Pulse wave Arterial Stiffness index	0.9	1.1	3.3	1.8	-0.9	-0.5
Tense / ‘highly strung’	0.9	1.4	2.7	1.6	1.1	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	2.9	0.1	-1.7	-1.1
Leg fat-free mass (right)	0.9	4.7	15.0	3.9	-0.3	1.9
Major Depression (MDD)	0.8	1.0	3.3	1.8	0.1	0.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	1.8	-0.2	-1.4	-1.2
Diabetes (father)	0.8	0.9	2.1	0.6	1.4	1.2
Townsend deprivation index at recruitment	0.8	1.1	2.7	1.0	1.6	0.8
Average weekly fortified wine intake	0.8	0.9	1.6	0.8	1.3	1.2
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	2.6	-1.6	-0.7	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	6.4	-0.9	-1.8	-2.5
Arm fat mass (right)	0.8	3.2	10.2	3.2	-0.2	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.3	1.0	1.5	1.3
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.0	-0.6	1.4	1.3
Whole body fat mass	0.8	3.3	11.3	3.4	-1.2	0.5
Leg fat mass (right)	0.8	3.0	10.9	3.3	-0.6	1.0
Suffer from ‘nerves’	0.8	1.3	4.1	0.9	0.5	2.0
Family relationship satisfaction	0.8	1.0	3.0	-0.2	-0.9	-1.7
Commuting to job workplace: Walk	0.8	0.9	2.2	-0.8	-1.5	-0.9
Leg predicted mass (right)	0.8	4.4	14.2	3.8	-0.3	1.8
Financial situation satisfaction	0.8	1.0	3.9	-0.2	-0.2	-2.0
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.5	-0.7	-1.6	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.2	-0.7	-1.5	-1.2
Leg fat mass (left)	0.8	3.0	10.4	3.2	-0.6	1.1
Crohns Disease (2012)	0.7	1.2	3.2	-1.8	0.0	1.2
BMI	0.7	4.1	9.8	3.1	1.0	2.4
Hypothyroidism (self reported)	0.7	1.6	3.7	1.9	-1.7	0.1
Taking other prescription medications	0.7	1.1	2.7	-0.6	-1.7	-1.1
Multivitamins +/- minerals	0.7	0.9	3.2	0.6	-0.0	1.8
Trunk fat mass	0.7	3.1	9.7	3.1	-1.7	0.2
Birth weight of first child	0.7	1.3	2.9	1.3	-1.7	-0.7
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.5	1.9	-1.2	0.4
Forced vital capacity (FVC), Best measure	0.7	2.4	5.6	-1.2	-1.7	-2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.4	-1.0	0.4	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	2.4	0.0	1.0	1.6
Number of self-reported non-cancer illnesses	0.7	1.3	4.0	2.0	-1.0	-0.1
Average weekly champagne plus white wine intake	0.7	1.0	2.6	-0.7	-1.6	-0.9
Miserableness	0.7	1.2	2.7	1.6	0.9	1.1
Alcohol drinker status: Previous	0.7	0.8	2.2	-0.5	-1.5	-1.0
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.5	0.1	-1.9	-1.5
Blood White Count	0.6	4.1	16.2	-0.1	4.0	-0.7
Severe depression (siblings)	0.6	0.7	1.9	1.4	0.4	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	3.2	0.1	1.8	0.8
Had other major operations	0.6	0.8	2.2	1.0	-0.0	1.5
High blood pressure (siblings)	0.6	0.9	3.2	1.8	-0.5	-0.1
Pulse wave peak to peak time	0.6	0.8	2.7	-1.6	0.5	0.3
Migraine (self-reported)	0.6	0.8	1.3	0.8	1.1	1.1
Medication: Seretide 50 evohaler	0.6	0.7	2.4	1.6	-0.5	-0.6
Mean time to correctly identify matches	0.6	1.1	4.0	-0.7	2.0	-0.2
Arm fat mass (left)	0.6	2.4	7.8	2.8	-0.4	1.3
Medication: Lisinopril	0.6	0.7	2.8	1.7	-0.0	0.4
Age started oral contraceptive pill	0.6	0.8	3.1	-1.8	-0.3	0.3
Vascular/heart problems diagnosed by doctor	0.6	1.5	5.6	-2.4	0.2	-0.7
Pain experienced in last month	0.6	1.0	3.1	0.4	-1.8	-0.8
Reaction Time	0.5	0.9	3.2	-0.5	1.8	-0.3
Body Mass Index (BMI) (2010)	0.5	0.7	1.6	0.8	0.8	1.3
Coronary Artery Disease (CAD)	0.5	0.6	2.2	-1.5	0.3	-0.4
Neuroticism (2016)	0.5	0.7	1.7	1.3	-0.7	0.7
Waist Hip Ratio (WHR)	0.5	2.4	8.3	-1.2	-0.1	-2.9
Lung FVC	0.5	2.3	6.1	-2.5	1.8	-0.0
Sensitivity / hurt feelings	0.5	0.9	2.7	-0.1	1.6	1.0
Current tobacco smoking	0.5	0.8	3.1	0.3	-0.4	-1.8
Fed-up feelings	0.5	0.9	2.8	1.7	0.6	-0.6
Age when periods started (menarche)	0.5	1.2	2.3	1.5	0.6	1.5
Hayfever, allergic rhinitis or eczema	0.5	1.2	3.0	1.3	-1.7	0.1
Sitting height	0.5	3.9	9.1	3.0	-2.5	-0.4
Chronic bronchitis/emphysema (father)	0.5	0.6	1.7	0.7	1.3	0.4
Illnesses of siblings	0.5	0.7	2.5	-1.6	0.0	-0.3
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.6	-1.1	-1.2	-1.9
Prospective memory result	0.5	0.6	1.3	-1.0	-0.1	-1.2
Breastfed as a baby	0.5	0.6	1.2	1.1	-1.1	-0.5
Headache pain in last month	0.5	0.8	2.5	0.1	1.6	0.9
Birth weight	0.5	1.0	2.4	1.3	-1.6	-0.3
Comparative body size at age 10	0.5	1.4	3.3	1.3	0.9	1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.8	-1.4	0.7	0.3
Health satisfaction	0.5	0.7	1.4	0.4	-1.2	-1.0
Medication: Blood pressure	0.5	1.0	1.8	0.8	-1.3	-1.2
Back pain experienced in last month	0.5	0.7	1.1	-1.1	-0.7	-1.1
Hearing aid user	0.5	0.6	2.0	-1.4	0.3	0.6
High cholesterol (Self-reported)	0.5	0.8	1.5	1.2	0.7	1.2
Illnesses of father: High blood pressure	0.5	0.6	0.9	0.7	0.9	1.0
Alcohol drinker status: Never	0.5	0.6	1.6	-1.3	-0.3	-0.8
Ever smoked	0.5	0.9	2.5	1.6	-0.9	0.4
Irritability	0.5	0.9	3.3	1.8	-0.2	0.2
Ever depressed for a whole week	0.5	0.6	2.2	1.5	-0.1	-0.3
Commuting to job workplace: Cycle	0.5	0.6	2.4	-0.0	0.1	-1.6
Bipolar Disorder or Schizophrenia	0.4	0.9	1.7	1.3	0.4	1.3
Rheumatoid Arthritis	0.4	0.5	1.5	-1.2	-0.8	-0.3
Ulcerative Colitis	0.4	0.6	1.1	-0.7	1.1	1.0
Blood Eosinophil Count	0.4	3.0	9.3	1.0	3.1	1.3
Blood Red Count	0.4	4.1	12.7	3.6	-1.2	-1.4
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.6	1.2	0.8	-0.4
Hearing difficulty/problems: Yes	0.4	0.6	2.4	-1.6	-0.1	-0.4
Relative age of first facial hair	0.4	0.7	1.9	-1.4	-0.4	1.0
Diabetes (mother)	0.4	0.5	1.2	1.1	0.7	-0.7
Trunk fat percentage	0.4	1.5	3.7	1.9	-1.5	0.0
Maternal smoking around birth	0.4	0.6	2.1	1.5	-0.1	-0.4
High blood pressure	0.4	1.2	4.4	2.1	-0.1	0.6
Waist circumference	0.4	1.6	5.7	2.4	-0.1	0.8
Past tobacco smoking	0.4	0.8	2.7	-1.6	0.3	-0.6
Financial difficulties in last 2 years	0.4	0.6	2.1	1.4	0.3	-0.3
Heart attack	0.4	0.5	1.7	0.4	1.3	0.3
Diabetes (self-reported)	0.4	0.7	2.2	-1.5	-0.4	-0.6
Fluid intelligence score	0.4	0.9	1.9	1.4	-1.3	-0.2
Arm fat percentage (right)	0.4	1.5	3.7	1.9	-0.2	1.5
Time employed in main current job	0.4	0.5	1.5	0.2	-1.2	-0.7
Hair/balding pattern: Pattern 3	0.4	0.6	1.3	-1.1	0.1	-1.1
Medication: Cholesterol lowering	0.4	0.7	1.2	0.9	0.8	1.1
Shortness of breath walking on level ground	0.4	0.4	1.1	0.8	1.1	0.0
Qualifications: College or University degree	0.4	1.1	1.8	-1.1	1.3	1.2
Eye problems/disorders: None of the above	0.4	0.4	1.5	1.2	0.4	0.3
Emphysema/chronic bronchitis	0.4	0.4	0.7	0.7	0.6	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.2	-0.5	-0.8	-1.1
Illnesses of siblings: Diabetes	0.4	0.5	1.9	1.4	0.0	0.4
Mood swings	0.4	0.7	2.4	1.5	0.8	-0.1
Diabetes diagnosed by doctor	0.4	0.7	2.2	-1.5	0.1	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.9	-0.2	0.9	0.9
Osteoarthritis (self-reported)	0.4	0.5	0.8	-0.6	0.9	0.9
Smoking status: Current	0.4	0.6	2.3	0.4	-0.2	-1.5
Eye problems/disorders: Glaucoma	0.4	0.5	1.1	0.6	-1.1	-0.7
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.2	-1.1	0.8	-0.5
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.6	0.6	0.4	1.3
Medication: Bendroflumethiazide	0.4	0.7	1.3	1.2	-0.8	-0.8
Myopia	0.4	0.6	2.2	0.1	-1.5	-0.4
Cholesterol lowering medication	0.4	0.6	1.3	0.5	0.9	1.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.4	0.7	1.2	0.2
Alzheimer’s Disease (including proxy)	0.3	0.5	1.0	0.6	-1.0	-0.7
Ovarian Cancer	0.3	0.4	1.2	0.5	-0.3	-1.1
Fasting Glucose	0.3	0.3	0.7	0.7	-0.3	-0.8
Heel T-Score	0.3	2.0	4.0	-2.0	1.2	-1.6
Systolic Blood Pressure	0.3	1.4	5.4	2.3	-0.2	-0.1
Smoking Status	0.3	0.7	2.3	1.5	0.5	0.5
Allergy or Eczema	0.3	0.8	2.0	1.1	-0.3	1.4
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.1	-1.0	1.0	-0.2
Number of treatments/medications taken	0.3	0.5	1.1	0.9	-1.0	-0.1
Systolic blood pressure, automated reading	0.3	1.0	3.1	1.8	0.2	0.9
Medication for hormone replacement therapy	0.3	0.3	1.1	-1.0	-0.4	0.1
Vitamin and mineral supplements	0.3	0.4	1.1	-0.8	0.2	-1.1
Stomach or abdominal pain in last month	0.3	0.3	0.9	-0.4	0.9	0.5
Supplements: Glucosamine	0.3	0.4	1.3	0.3	-1.2	-0.1
High blood pressure (mother)	0.3	0.4	0.9	0.6	-1.0	-0.7
Qualifications: None of the above	0.3	0.7	1.7	0.4	1.3	1.0
Pain all over the body in last month	0.3	0.3	1.0	-1.0	-0.0	0.6
Worrier / anxious feelings	0.3	0.6	2.3	1.5	0.5	-0.1
Pulse rate	0.3	0.6	1.9	0.1	-0.6	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.1	1.1	0.3	0.5
Length of working week for main job	0.3	0.3	0.7	-0.6	-0.3	-0.9
Loud music exposure frequency	0.3	0.4	0.6	0.8	-0.5	-0.8
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.5	1.2	0.1	-0.1
Body fat percentage	0.3	1.1	3.2	1.8	-1.0	0.4
Leg fat percentage (right)	0.3	1.3	4.4	2.1	-0.6	0.5
Neck or shoulder pain in last month	0.3	0.4	1.2	-1.1	0.3	0.3
Had major operations	0.3	0.4	0.9	1.0	0.4	0.7
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.8	0.1	0.9	0.8
Smoking status: Previous	0.3	0.4	0.9	1.0	0.1	0.8
Qualifications: nursing, teaching	0.3	0.5	1.7	0.1	0.4	1.3
Ever taken oral contraceptive pill	0.3	0.3	1.1	-0.2	0.3	1.0
Mother’s age at death	0.3	0.3	0.8	-0.6	0.4	-0.9
Leg fat percentage (left)	0.3	1.0	3.5	1.9	-0.5	0.7
Unable to work because of sickness or disability	0.3	0.4	1.4	-1.2	-0.6	-0.3
Prostate Cancer	0.2	0.3	1.0	1.0	-0.4	0.5
HDL Cholesterol	0.2	0.4	1.3	-0.3	-1.1	0.5
LDL Cholesterol	0.2	0.3	0.7	0.6	0.8	0.3
Primary Biliary Cirrhosis	0.2	0.2	0.9	-0.9	-0.1	-0.0
Blood Platelet Count	0.2	2.8	5.7	-1.8	1.4	2.4
Chronotype (morning person)	0.2	0.4	1.6	-0.0	0.3	-1.3
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	-0.5	0.3	0.6
Medication: Co-codamol	0.2	0.3	1.0	-0.2	-1.0	-0.1
Medication: Metformin	0.2	0.3	0.9	-0.2	0.9	-0.6
Relative age voice broke	0.2	0.3	0.8	-0.9	-0.6	0.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.7	-0.2	-0.8	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.8	-0.8	0.3	-0.9
Medication: Atenolol	0.2	0.2	0.8	-0.9	0.1	0.3
Forced vital capacity (FVC)	0.2	0.9	1.6	-1.1	-0.9	-1.2
Allergy	0.2	0.4	1.1	-0.7	1.1	-0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.6	0.8	0.2	0.6
Neuroticism score	0.2	0.5	1.4	1.2	0.7	0.4
Alcohol intake versus 10 years previously	0.2	0.3	0.9	0.2	-0.2	1.0
Number of live births	0.2	0.2	0.9	0.1	0.9	-0.0
Asthma	0.2	0.3	0.9	1.0	-0.6	-0.2
Illnesses of mother	0.2	0.3	0.9	-0.3	-0.2	0.9
Hair/balding pattern: Pattern 4	0.2	0.5	1.0	1.0	0.8	0.8
Medication: Paracetamol	0.2	0.3	1.0	1.0	0.4	-0.1
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.5	0.7	0.7	0.4
Number of children fathered	0.2	0.2	0.5	-0.1	-0.5	-0.7
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	-0.4	-0.5	-0.8
Alcohol intake frequency.	0.2	0.4	0.7	-0.9	-0.8	-0.4
Supplements: Vitamin C	0.2	0.3	0.9	0.3	-0.4	-0.9
Hypertension (Self-reported)	0.2	0.6	2.0	1.4	-0.2	0.7
Arm fat percentage (left)	0.2	1.0	2.1	1.4	-0.3	1.3
Average weekly red wine intake	0.2	0.2	0.8	0.9	-0.0	0.4
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.7	-0.9	-0.3	0.4
Loneliness, isolation	0.2	0.3	0.7	0.6	0.9	0.2
Medication for cholesterol	0.2	0.3	0.7	0.7	0.8	0.4
Asthma (self-reported)	0.2	0.4	0.8	0.9	-0.8	-0.5
Wears glasses or contact lenses	0.2	0.2	0.6	-0.2	-0.8	0.3
Supplements: Calcium	0.2	0.3	0.7	-0.5	0.3	0.8
Basal cell carcinoma (self-reported)	0.2	0.2	0.7	-0.1	0.3	0.8
Depressed Affect (Nagel 2018)	0.1	0.2	0.8	0.9	0.0	-0.1
Depression (Nagel 2018)	0.1	0.1	0.4	0.6	-0.0	0.1
Neuroticism (Nagel 2018)	0.1	0.1	0.4	0.3	0.6	0.3
Schizophrenia (2018)	0.1	0.3	0.5	0.7	-0.7	0.3
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	0.5	-0.4	-0.1
Mean Putamen Volume	0.1	0.1	0.3	0.5	-0.0	-0.6
Triglycerides	0.1	0.2	0.5	0.7	0.3	-0.5
Respiratory disease	0.1	0.3	0.6	0.8	0.2	0.7
Neuroticism	0.1	0.4	0.7	0.7	0.5	0.8
Tanning	0.1	0.7	2.1	0.6	1.4	0.8
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.5	0.5	-0.2
Supplements: Zinc	0.1	0.1	0.4	0.6	0.2	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	0.5	-0.3	-0.2
Serious illness, injury or assault to yourself	0.1	0.2	0.4	0.2	0.6	0.5
Number of incorrect matches in round	0.1	0.2	0.9	-0.0	-0.9	0.0
Alcohol usually taken with meals	0.1	0.2	0.7	0.1	-0.8	-0.2
Nervous feelings	0.1	0.3	0.4	-0.5	0.6	0.7
Hearing difficulty/problems with background noise	0.1	0.2	0.5	-0.7	0.2	0.2
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.5	0.1	0.2
Had menopause	0.1	0.1	0.3	-0.1	0.5	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.7	-0.6	0.8	-0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	0.0	0.3	-0.6
Medication: Simvastatin	0.1	0.2	0.3	-0.6	0.4	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.4	0.3	0.6	0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.2	-0.3	-1.1	-0.2
Mouth/teeth dental problems: Dentures	0.1	0.1	0.3	0.0	-0.6	-0.1
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	-0.1	0.5	0.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	0.0	-0.5	-0.6
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.8	-0.9	-0.1	-0.0
Glaucoma (self-reported)	0.1	0.1	0.3	0.5	-0.4	-0.3
Gout (self-reported)	0.1	0.2	0.4	0.7	0.5	-0.4
Worry too long after embarrassment	0.1	0.2	0.6	-0.1	0.1	-0.8
Pulse rate, automated reading	0.1	0.3	0.5	0.6	0.7	0.6
Long-standing illness, disability or infirmity	0.1	0.1	0.2	-0.1	-0.4	-0.3
Mineral and other dietary supplements	0.1	0.2	0.6	0.3	-0.0	-0.8
Breast cancer (self-reported)	0.1	0.1	0.5	-0.7	-0.0	0.1
Illnesses of father: None of the above (group 1)	0.1	0.1	0.5	-0.7	0.2	-0.2
Medication: Blood pressure	0.1	0.2	0.8	0.0	0.1	0.9
Fractured/broken bones in last 5 years	0.1	0.1	0.2	-0.1	-0.3	0.5
Heart disease (siblings)	0.1	0.2	0.3	0.3	0.6	0.4
Intelligence (Savage-Jansen 2018)	0.0	0.0	0.1	0.1	0.0	0.3
Worry (Nagel 2018)	0.0	0.1	0.2	-0.3	0.5	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.0	0.1	0.3	0.1	-0.5	0.1
Hair Pigment	0.0	0.3	1.2	0.3	-0.2	1.1
Father’s age at death	0.0	0.1	0.2	-0.2	-0.4	0.1
Peak expiratory flow (PEF)	0.0	0.1	0.3	-0.0	-0.1	0.6
Wheeze or whistling in the chest in last year	0.0	0.0	0.1	0.3	-0.2	-0.1
Overall health rating	0.0	0.1	0.3	-0.1	-0.1	-0.6
Leg pain on walking	0.0	0.0	0.0	0.2	0.1	0.1
Illnesses of father: Heart disease	0.0	0.0	0.1	0.1	-0.1	0.3
Guilty feelings	0.0	0.0	0.2	0.1	0.1	-0.4
Medication: Paracetamol	0.0	0.1	0.3	-0.2	0.5	-0.1

Hub : Genes

PRSS50

Models

Trait associations