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chr1:25,475,418-27,820,430

Best TWAS P=6.3e-12 · Best GWAS P=1.62e-10 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	PDIK1L	0.03	0.01	blup	37	0.02	2.6e-03	5.8	-6.9	6.3e-12	-0.87	0.01	0.55	TRUE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDIK1L	0.02	0.02	blup	37	0.02	2.8e-03	6.4	-6.4	1.2e-10	-0.95	0.01	0.85	TRUE
6	GTEx	Spleen	PIGV	0.16	0.13	lasso	13	0.16	6.6e-05	5.6	-6.4	2.0e-10	-0.05	0.27	0.16	TRUE
1	GTEx	Esophagus Mucosa	PDIK1L	0.10	0.09	lasso	6	0.09	8.8e-07	6.4	-6.3	3.8e-10	-0.99	0.02	0.98	TRUE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	FAM54B	0.06	0.01	blup	63	0.04	1.8e-09	5.0	-6.1	9.4e-10	-0.32	0.02	0.97	TRUE
9	GTEx	Whole Blood	CEP85	0.07	0.01	enet	17	0.02	1.3e-02	-2.0	-5.8	5.9e-09	-0.31	0.16	0.43	TRUE
8	GTEx	Thyroid	SEPN1	0.10	0.03	lasso	3	0.04	7.0e-04	-4.5	-5.6	1.7e-08	-0.39	0.89	0.01	TRUE
25	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RPS6KA1	0.11	0.05	lasso	6	0.07	8.0e-04	-6.3	5.4	8.2e-08	0.11	0.01	0.89	TRUE
4	GTEx	Skin Not Sun Exposed Suprapubic	PDIK1L	0.22	0.05	enet	37	0.11	8.3e-07	6.4	-5.2	2.0e-07	-0.80	0.02	0.98	TRUE
2	GTEx	Muscle Skeletal	PIGV	0.07	0.01	enet	12	0.02	2.1e-03	4.3	-5.2	2.4e-07	-0.20	0.46	0.10	TRUE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRIM63	0.29	0.33	enet	20	0.33	2.5e-38	6.3	6.8	1.2e-11	0.95	0.01	0.99	FALSE
11	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIM63	0.03	0.02	blup	33	0.02	4.6e-03	6.4	6.6	3.4e-11	0.93	0.01	0.88	FALSE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRIM63	0.15	0.16	lasso	2	0.16	2.3e-32	6.4	6.4	1.4e-10	0.98	0.00	1.00	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	TRIM63	0.18	0.26	enet	7	0.26	3.0e-25	6.2	6.4	1.5e-10	0.95	0.01	0.99	FALSE
14	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TRIM63	0.14	0.15	lasso	1	0.14	2.2e-07	6.4	6.4	1.8e-10	0.96	0.01	0.99	FALSE
24	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TRIM63	0.14	0.18	lasso	7	0.15	3.0e-10	6.3	6.4	1.8e-10	0.96	0.01	0.99	FALSE
15	The Cancer Genome Atlas	Colon Adenocarcinoma	TRIM63	0.08	0.10	lasso	4	0.10	3.7e-06	6.3	6.4	1.9e-10	0.97	0.01	0.99	FALSE
23	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TRIM63	0.16	0.11	lasso	1	0.10	2.0e-11	6.3	6.3	2.5e-10	0.99	0.01	0.99	FALSE
22	The Cancer Genome Atlas	Lung Adenocarcinoma	TRIM63	0.14	0.20	enet	7	0.21	9.4e-24	6.2	6.3	3.3e-10	0.96	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TRIM63	0.19	0.07	blup	33	0.14	1.3e-04	6.3	6.2	6.9e-10	0.90	0.01	0.99	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC30A2	0.03	0.02	lasso	3	0.01	1.1e-02	5.2	-6.1	1.3e-09	-0.76	0.02	0.91	FALSE
27	The Cancer Genome Atlas	Rectum Adenocarcinoma	TRIM63	0.28	0.22	lasso	3	0.20	1.7e-05	5.2	6.0	1.9e-09	0.75	0.02	0.90	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRIM63	0.11	0.11	enet	4	0.12	9.0e-14	6.3	5.8	5.3e-09	0.96	0.01	0.99	FALSE
7	GTEx	Thyroid	CNKSR1	0.10	0.04	lasso	7	0.03	2.1e-03	5.5	-5.7	1.4e-08	-0.70	0.09	0.89	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	MTFR1L	0.23	0.25	lasso	5	0.30	7.4e-39	-4.6	-5.6	2.0e-08	-0.28	1.00	0.00	FALSE
5	GTEx	Skin Sun Exposed Lower leg	PDIK1L	0.14	0.05	enet	23	0.12	3.1e-10	6.4	-5.6	2.2e-08	-0.78	0.02	0.98	FALSE
3	GTEx	Nerve Tibial	PDIK1L	0.09	0.01	enet	10	0.03	2.2e-03	5.0	-5.5	3.3e-08	-0.74	0.20	0.74	FALSE
28	The Cancer Genome Atlas	Soft Tissue Sarcoma	FAM54B	0.11	0.03	blup	63	0.09	3.3e-06	-4.0	-5.5	3.6e-08	-0.29	0.04	0.87	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	SH3BGRL3	0.05	0.03	lasso	2	0.03	9.3e-04	4.7	5.3	1.1e-07	0.55	0.00	0.91	FALSE
16	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GRRP1	0.11	0.02	blup	52	0.03	8.8e-05	-3.6	5.3	1.3e-07	0.51	0.02	0.29	FALSE