TWAS hub - EIF3I

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Not Sun Exposed Suprapubic	0.116	0.0540	5.8e-03	0.061	NA	0.006	NA	0.032	0.0003	NA	1.3e-01	NA	0.00720
2	ROSMAP	Brain Pre-frontal Cortex	0.120	0.0392	1.9e-05	-0.002	0.038	0.052	0.041	0.024	0.6100	9.4e-06	2.8e-07	4.6e-06	0.00041

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Eye problems/disorders: None of the above	5.2	6.1	10.4	1.3	3.2
Medication: Co-codamol	4.5	5.2	5.9	-2.1	-2.4
Sitting height	3.8	26.8	47.2	-6.9	-2.5
Arm fat-free mass (right)	3.7	18.8	36.5	-6.0	-1.1
Arm predicted mass (right)	3.7	18.7	35.8	-6.0	-1.3
Supplements: Calcium	3.6	3.9	5.5	-1.5	-2.3
Length of working week for main job	3.5	3.8	4.6	1.7	2.1
Mineral and other dietary supplements	3.5	4.7	6.4	2.5	1.7
Arm fat-free mass (left)	3.5	17.8	33.9	-5.8	-1.3
Arm predicted mass (left)	3.5	17.7	33.6	-5.8	-1.3
Chronic bronchitis/emphysema (father)	3.3	3.8	5.0	1.6	2.2
Number of live births	3.2	4.6	8.8	-3.0	-0.6
Comparative height size at age 10	3.2	17.6	28.2	-5.3	-2.6
Ever depressed for a whole week	3.2	4.0	4.1	-2.0	-2.0
Trunk fat-free mass	3.1	17.8	33.2	-5.8	-1.5
Trunk predicted mass	3.1	17.8	33.3	-5.8	-1.5
Standing height	3.1	30.4	47.5	-6.9	-3.6
Illnesses of father: High blood pressure	3.1	3.8	6.7	2.6	-1.0
Whole body fat-free mass	3.0	17.3	32.6	-5.7	-1.4
Eye problems/disorders: Cataract	3.0	3.5	5.2	-1.3	-2.3
Whole body water mass	3.0	17.1	31.9	-5.7	-1.5
Basal metabolic rate	3.0	16.3	31.1	-5.6	-1.2
Pulse wave Arterial Stiffness index	2.8	3.3	5.8	-2.4	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.8	3.4	6.1	-2.5	-0.8
Unable to work because of sickness or disability	2.8	3.6	7.1	-0.3	2.7
Fluid intelligence score	2.7	5.7	7.0	-2.1	-2.6
Leg fat-free mass (left)	2.6	13.8	26.3	-5.1	-1.1
Tinnitus: Yes, now most or all of the time	2.6	3.1	5.6	-2.4	-0.7
Verbal and Numeric Reasoning (VNR)	2.5	6.0	6.9	-2.6	-2.2
Qualifications: CSEs or equivalent	2.5	3.3	3.9	1.6	2.0
Supplements: Glucosamine	2.5	3.2	3.9	-1.6	-2.0
Leg predicted mass (left)	2.5	13.2	25.1	-5.0	-1.1
Supplements: Fish oil (including cod liver oil)	2.5	3.3	6.2	-2.5	-0.7
Pulse wave peak to peak time	2.4	2.8	3.6	1.9	-1.4
Medication: Allopurinol	2.4	3.3	4.0	-2.0	-1.6
Had major operations	2.4	2.8	5.2	-0.7	-2.3
Leg fat-free mass (right)	2.4	12.6	24.1	-4.9	-1.1
Weight	2.3	11.4	22.3	-4.7	-0.7
Suffer from ‘nerves’	2.3	3.6	6.5	2.5	0.8
Leg predicted mass (right)	2.3	12.5	23.9	-4.9	-1.1
Height	2.2	42.9	70.7	-8.4	-3.9
Multivitamins +/- minerals	2.2	2.8	4.4	-1.1	-2.1
Rheumatoid Arthritis	2.1	2.9	3.6	-1.9	-1.5
Number of self-reported non-cancer illnesses	2.1	3.6	4.4	-2.1	-1.7
Maternal smoking around birth	2.0	2.9	3.2	-1.6	1.8
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	4.8	0.1	2.2
Relative age voice broke	1.9	2.9	5.5	-2.3	-0.5
Had other major operations	1.9	2.3	4.3	-2.1	-0.6
Pulse wave reflection index	1.9	2.3	3.5	-1.9	1.1
Illnesses of father: None of the above (group 1)	1.9	2.4	4.6	-2.2	-0.3
Number of treatments/medications taken	1.8	3.2	4.1	-2.0	-1.5
Medication: Lansoprazole	1.8	2.0	4.0	-2.0	-0.1
Number of operations (self-reported)	1.8	2.6	3.8	-1.9	-1.2
Intelligence (Savage-Jansen 2018)	1.7	5.1	6.0	-2.5	-2.0
Diabetes (father)	1.7	2.2	3.7	0.8	1.9
Trunk fat mass	1.7	7.2	14.5	-3.8	-0.1
Serious illness, injury or assault of a close relative in last 2 years	1.7	2.0	3.9	-0.3	-2.0
Leg fat mass (left)	1.7	6.6	12.9	-3.6	0.6
Type 2 Diabetes (T2D) (2012)	1.6	1.8	3.5	0.4	-1.9
Mouth/teeth dental problems: Dentures	1.6	2.7	2.8	1.7	1.6
Prospective memory result	1.6	2.0	3.8	2.0	0.3
Number of full brothers	1.6	2.1	2.6	1.2	1.6
Age at first live birth	1.6	2.9	5.7	-0.1	-2.4
Whole body fat mass	1.6	6.8	13.4	-3.7	0.4
Leg fat mass (right)	1.6	6.0	11.7	-3.4	0.6
Commuting to job workplace: Public transport	1.6	1.9	2.8	-1.7	-1.0
High cholesterol (Self-reported)	1.6	2.8	3.4	-1.8	-1.5
Taking other prescription medications	1.5	2.3	4.4	-2.1	-0.5
Breastfed as a baby	1.5	1.9	3.7	-1.9	-0.4
Mouth/teeth dental problems: Mouth ulcers	1.5	2.3	3.8	-2.0	-0.9
Depression (Nagel 2018)	1.4	2.1	3.9	-2.0	-0.4
Hand grip strength (left)	1.4	3.7	4.2	-2.0	-1.8
Hearing difficulty/problems: Yes	1.4	2.2	3.1	-1.8	-1.1
Supplements: Zinc	1.4	1.5	2.3	-0.9	-1.5
Bilateral oophorectomy (both ovaries removed)	1.4	1.7	2.8	-1.7	-0.7
Had menopause	1.4	1.8	2.4	-1.5	-1.1
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	2.8	-0.8	-1.7
Medication: Blood pressure	1.4	2.4	4.4	-2.1	-0.7
Wears glasses or contact lenses	1.4	1.6	2.9	-1.7	-0.6
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.3	-1.5	-0.7
Waist circumference	1.3	4.7	9.2	-3.0	0.3
Pain all over the body in last month	1.3	1.4	2.5	1.6	0.6
Hip circumference	1.3	5.5	10.6	-3.3	0.6
Illnesses of siblings: Diabetes	1.3	1.6	2.1	-1.0	-1.5
Age started oral contraceptive pill	1.3	1.6	3.1	0.3	-1.8
Lupus	1.2	1.8	3.3	-1.8	-0.6
Diabetes (mother)	1.2	1.6	2.6	-1.6	0.8
Alcohol intake versus 10 years previously	1.2	1.7	3.0	-1.7	0.7
Arm fat mass (right)	1.2	4.9	9.4	-3.1	0.6
Qualifications: nursing, teaching	1.2	1.9	2.0	1.4	-1.4
Arm fat mass (left)	1.2	4.7	9.0	-3.0	0.7
Mean Putamen Volume	1.1	1.3	1.4	1.1	1.2
Schizophrenia (2014)	1.1	2.3	2.6	1.6	1.4
Medication for hormone replacement therapy	1.1	1.2	1.7	1.3	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.6	3.0	-1.7	-1.5
Qualifications: None of the above	1.1	2.4	4.4	0.7	2.1
Heart attack	1.1	1.4	2.0	-0.9	1.4
Hair/balding pattern: Pattern 3	1.1	1.6	2.9	0.5	1.7
Medication: Amlodipine	1.1	1.6	2.0	-1.1	-1.4
Mouth/teeth dental problems: Loose teeth	1.1	1.3	1.5	1.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	4.7	-0.3	-2.2
Heart attack/myocardial infarction (self-reported)	1.1	1.4	2.2	-0.8	1.5
Alcohol drinker status: Previous	1.1	1.3	2.4	-0.3	1.6
Ever used hormone-replacement therapy (HRT)	1.0	1.2	2.2	-0.5	-1.5
Vitamin and mineral supplements	1.0	1.4	1.5	1.2	1.1
Hand grip strength (right)	1.0	2.6	3.3	-1.4	-1.8
High blood pressure (mother)	1.0	1.3	2.1	1.4	0.8
Hair/balding pattern: Pattern 2	1.0	1.2	1.3	-1.1	-1.1
Forced vital capacity (FVC)	1.0	3.9	5.4	-2.3	-1.6
Birth weight of first child	1.0	1.8	2.4	-1.6	-1.1
Loud music exposure frequency	1.0	1.1	2.1	-1.4	-0.4
Migraine (self-reported)	1.0	1.2	2.2	-0.4	-1.5
Age at last live birth	1.0	1.4	2.3	-0.8	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	3.8	-2.0	-0.6
Diabetes diagnosed by doctor	1.0	1.6	1.6	-1.3	1.2
Commuting to job workplace: Walk	1.0	1.1	2.0	1.4	-0.5
Ever taken oral contraceptive pill	1.0	1.1	2.2	-0.2	1.5
Bipolar Disorder (2018)	0.9	1.4	1.9	1.4	0.9
Breast Cancer	0.9	2.1	3.3	-1.8	-1.0
Coronary Artery Disease (CAD)	0.9	1.1	1.5	-0.8	1.2
Smoking Status	0.9	2.2	4.5	-2.1	-0.1
Diabetes (self-reported)	0.9	1.4	2.6	-1.6	0.3
Illnesses of siblings	0.9	1.3	1.7	0.9	1.3
Tense / ‘highly strung’	0.9	1.5	1.5	1.2	-1.2
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	2.0	-1.4	-0.8
Forced vital capacity (FVC), Best measure	0.9	3.3	3.4	-1.9	-1.8
Neck or shoulder pain in last month	0.9	1.3	1.6	1.3	1.0
Medication: Ibuprofen	0.9	1.1	1.6	1.3	-0.7
Overall health rating	0.9	2.0	4.0	-0.1	2.0
Leg pain on walking	0.9	1.1	1.1	-1.1	-1.0
Medication: Aspirin	0.9	1.1	1.7	-1.3	-0.8
Asthma (self-reported)	0.9	1.8	2.6	-1.6	-1.0
Medication: Aspirin	0.9	1.2	1.6	-1.3	-0.9
Medication: Atorvastatin	0.9	1.1	2.0	-0.5	1.4
Pain experienced in last month	0.9	1.5	3.0	-1.7	-0.2
Bipolar Disorder or Schizophrenia	0.8	2.0	2.4	1.6	1.2
Major Depression (MDD)	0.8	0.9	1.3	-0.7	-1.1
Prostate Cancer	0.8	1.2	2.2	0.3	-1.5
BMI	0.8	4.9	9.8	-3.1	0.2
Relative age of first facial hair	0.8	1.6	2.5	-0.8	1.6
Alcohol usually taken with meals	0.8	1.4	2.5	0.5	-1.6
Heart disease (mother)	0.8	1.0	1.8	-1.3	-0.4
Average weekly red wine intake	0.8	1.2	1.7	0.8	-1.3
Heart disease (siblings)	0.8	1.0	1.7	-0.5	-1.3
Blood Eosinophil Count	0.7	5.3	6.4	-2.5	-2.1
Cardiovascular Disease	0.7	2.2	3.4	-1.9	-1.0
Type 2 Diabetes (T2D) (2018)	0.7	1.4	2.7	-1.6	0.2
Systolic blood pressure, automated reading	0.7	2.2	3.2	1.8	1.0
Severe depression (siblings)	0.7	0.8	1.5	1.2	0.3
Pack years adult smoking proportion	0.7	1.1	2.1	0.3	1.4
Trunk fat percentage	0.7	2.7	5.1	-2.3	0.5
Townsend deprivation index at recruitment	0.7	0.9	1.8	0.1	1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	1.7	-1.3	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.1	-0.3	1.4
Asthma	0.7	1.5	2.2	-1.5	-0.8
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.2	1.5	0.1
Qualifications: College or University degree	0.7	2.3	4.4	0.4	-2.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.3	0.5	1.2
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.7	-1.3	-0.1
Medication: Bendroflumethiazide	0.7	1.1	1.8	-0.6	-1.3
Leg fat percentage (left)	0.7	2.5	2.7	-1.6	1.5
Worry (Nagel 2018)	0.6	1.3	2.4	1.5	0.5
LDL Cholesterol	0.6	1.0	1.5	0.6	1.2
Blood White Count	0.6	4.1	7.8	-2.8	-0.6
Sensitivity / hurt feelings	0.6	1.0	2.1	0.0	1.4
Medication: Metformin	0.6	0.8	1.6	-1.3	-0.2
Fed-up feelings	0.6	1.1	2.2	-0.3	1.5
Medication: Levothyroxine sodium	0.6	1.0	1.3	-1.1	-0.8
Father’s age at death	0.6	0.8	1.3	-0.6	-1.1
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	2.5	-1.6	-1.2
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.7	-0.1	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	2.1	-1.3	-1.5
Peak expiratory flow (PEF)	0.6	1.3	2.2	-1.5	-0.6
Body fat percentage	0.6	2.2	3.8	-1.9	0.8
Leg fat percentage (right)	0.6	2.2	2.5	-1.6	1.4
Emphysema/chronic bronchitis	0.6	0.6	1.2	0.2	1.1
Alcohol intake frequency.	0.6	1.5	2.3	-0.9	1.5
Average weekly champagne plus white wine intake	0.6	0.8	1.3	-1.1	-0.5
Average weekly beer plus cider intake	0.6	0.8	1.6	-0.2	1.2
Vascular/heart problems diagnosed by doctor	0.6	1.6	2.2	1.5	1.0
High blood pressure	0.5	1.3	2.0	-1.4	-0.8
Stomach or abdominal pain in last month	0.5	0.7	1.3	-0.1	1.2
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.3	-1.1	-0.1
Body mass index (BMI)	0.5	2.2	3.1	-1.8	1.1
Allergy	0.5	1.2	2.0	1.4	0.5
Worrier / anxious feelings	0.5	1.0	1.4	-0.8	-1.2
Lung cancer (father)	0.5	0.6	1.0	-1.0	0.5
Medication: Paracetamol	0.5	0.8	1.6	0.4	1.2
Gout (self-reported)	0.5	0.6	1.2	-1.1	-0.0
Number of full sisters	0.5	0.6	1.2	-1.1	0.1
Supplements: Vitamin C	0.5	0.6	1.1	-1.1	-0.1
Hypertension (Self-reported)	0.5	1.3	1.5	-1.2	-1.1
Illnesses of father: Heart disease	0.5	0.7	1.1	-0.5	-1.0
Long-standing illness, disability or infirmity	0.5	0.8	1.7	-1.3	-0.1
Back pain experienced in last month	0.5	0.8	0.9	0.9	0.8
Hearing aid user	0.5	0.5	0.9	-1.0	-0.4
Eye problems/disorders: Glaucoma	0.5	0.6	0.7	0.7	-0.8
Medication: Lisinopril	0.5	0.7	1.4	-1.2	0.2
Schizophrenia (2018)	0.4	0.9	1.0	0.9	1.0
Reaction Time	0.4	0.9	1.1	0.8	1.1
Ulcerative Colitis	0.4	0.5	0.9	-1.0	0.4
Systolic Blood Pressure	0.4	2.2	2.6	1.3	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.7	-0.8	0.6
Serious illness, injury or assault to yourself	0.4	0.5	0.9	0.4	0.9
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.0	-1.0	-1.0
Medication: Atenolol	0.4	0.4	0.4	0.7	-0.7
Number of incorrect matches in round	0.4	0.7	1.2	0.5	1.1
Past tobacco smoking	0.4	0.7	1.1	1.0	-0.5
Financial difficulties in last 2 years	0.4	0.5	0.9	0.9	0.4
Impedance of arm (right)	0.4	2.0	3.9	2.0	-0.4
Headache pain in last month	0.4	0.6	1.2	-0.2	-1.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.3	-1.1	-0.5
Wheeze or whistling in the chest in last year	0.4	0.7	1.3	0.4	1.1
Pulse rate, automated reading	0.4	1.4	2.7	-1.6	-0.1
Knee pain experienced in last month	0.4	0.6	0.9	1.0	-0.5
Smoking status: Previous	0.4	0.5	1.0	-1.0	0.3
Arm fat percentage (left)	0.4	1.6	1.6	-1.2	1.3
Medication for cholesterol	0.4	0.7	1.3	-1.1	0.3
Myopia	0.4	0.6	0.6	-0.8	-0.7
Cholesterol lowering medication	0.4	0.6	1.0	-0.3	-1.0
Pack years of smoking	0.4	0.6	1.1	0.1	1.1
Neuroticism (2016)	0.3	0.4	0.8	-0.9	-0.1
Triglycerides	0.3	0.5	0.5	-0.7	0.7
Allergy or Eczema	0.3	0.9	1.3	-0.7	-1.1
Current tobacco smoking	0.3	0.5	0.9	-1.0	0.3
Average weekly fortified wine intake	0.3	0.3	0.6	-0.2	-0.8
Age when periods started (menarche)	0.3	0.6	0.8	0.9	-0.7
Nervous feelings	0.3	0.5	1.0	1.0	-0.2
Hearing difficulty/problems with background noise	0.3	0.5	1.0	-0.2	-1.0
Mouth/teeth dental problems	0.3	0.4	0.8	-0.2	-0.9
Arm fat percentage (right)	0.3	1.3	1.4	-1.1	1.2
Time employed in main current job	0.3	0.3	0.7	0.0	0.8
Noisy workplace	0.3	0.4	0.5	-0.5	0.7
Medication: Cholesterol lowering	0.3	0.4	0.5	-0.7	0.6
Impedance of arm (left)	0.3	1.6	2.8	1.7	-0.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.4	-0.6	-0.6
Blood clot in the leg (DVT)	0.3	0.4	0.7	0.8	0.4
Health satisfaction	0.3	0.3	0.6	-0.4	0.7
Chest pain or discomfort	0.3	0.4	0.7	0.9	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.5	-0.7	0.3
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.6	0.8	-0.1
Mood swings	0.3	0.5	0.6	-0.8	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	-0.7	0.4
Smoking status: Current	0.3	0.5	1.0	-1.0	-0.2
Medication: Paracetamol	0.3	0.4	0.5	0.7	0.6
Alcohol drinker status: Never	0.3	0.4	0.4	-0.6	-0.6
Basal cell carcinoma (self-reported)	0.3	0.3	0.6	-0.8	0.0
Depressed Affect (Nagel 2018)	0.2	0.4	0.7	-0.8	-0.2
Schizophrenia vs Biploar Disorder	0.2	0.3	0.5	0.4	-0.7
Alzheimer’s Disease (in mother)	0.2	0.3	0.4	0.3	0.6
Alzheimer’s Disease (in father)	0.2	0.2	0.3	0.6	-0.1
Crohns Disease (2012)	0.2	0.3	0.6	-0.8	0.1
Fasting Glucose	0.2	0.2	0.2	0.3	0.5
Blood Platelet Count	0.2	2.2	2.9	-1.7	-1.3
Blood Red Count	0.2	1.5	2.5	-1.6	-0.6
Waist Hip Ratio (WHR)	0.2	0.7	1.2	-1.1	-0.5
Respiratory disease	0.2	0.5	0.8	-0.9	0.5
Lung FVC	0.2	1.0	1.9	-0.3	-1.4
Neuroticism	0.2	0.4	0.7	0.8	0.4
Chronotype (morning person)	0.2	0.4	0.6	0.4	-0.7
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.4	-0.6	-0.4
Medication: Simvastatin	0.2	0.2	0.4	-0.7	-0.2
Neuroticism score	0.2	0.4	0.6	0.8	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.4	0.7	-0.4
Glaucoma (self-reported)	0.2	0.3	0.5	-0.2	-0.7
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.3	-0.5	0.5
Number of children fathered	0.2	0.2	0.3	-0.1	-0.6
Shortness of breath walking on level ground	0.2	0.2	0.5	-0.2	0.7
Medication for pain relief, constipation, heartburn	0.2	0.3	0.5	-0.7	-0.4
Angina (self-reported)	0.2	0.3	0.4	0.3	0.6
Family relationship satisfaction	0.2	0.2	0.4	-0.2	-0.6
Loneliness, isolation	0.2	0.2	0.4	-0.3	-0.6
Ever had bowel cancer screening	0.2	0.2	0.3	-0.5	-0.4
Miserableness	0.2	0.3	0.3	-0.5	0.5
Guilty feelings	0.2	0.3	0.5	0.7	0.2
Mother’s age at death	0.2	0.2	0.4	0.0	-0.7
Medication: Blood pressure	0.2	0.4	0.8	0.0	-0.9
Irritability	0.2	0.4	0.5	0.7	-0.5
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.5	0.1	-0.7
Fractured/broken bones in last 5 years	0.2	0.3	0.4	0.5	0.6
Diastolic blood pressure, automated reading	0.2	0.5	0.6	0.6	0.8
Commuting to job workplace: Cycle	0.2	0.3	0.5	0.0	0.7
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	0.7	0.4
Impedance of whole body	0.2	1.0	1.9	1.4	-0.3
Alzheimer’s Disease (including proxy)	0.1	0.2	0.2	0.5	0.4
Crohns Disease (2017)	0.1	0.3	0.3	0.5	0.6
Body Mass Index (BMI) (2010)	0.1	0.2	0.4	-0.6	0.1
HbA1C	0.1	0.1	0.2	-0.5	-0.2
Heel T-Score	0.1	0.8	1.6	-0.1	1.3
Hypothyroidism (self reported)	0.1	0.3	0.6	-0.8	-0.3
Tanning	0.1	0.7	0.8	0.7	0.9
Average weekly spirits intake	0.1	0.1	0.1	0.2	0.4
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	-0.4	-0.0
Angina	0.1	0.2	0.3	0.3	0.6
Impedance of leg (right)	0.1	0.7	1.3	1.1	-0.1
Impedance of leg (left)	0.1	0.7	1.3	1.2	0.3
Falls in the last year	0.1	0.1	0.2	-0.0	0.4
Pulse rate	0.1	0.1	0.2	-0.4	0.3
Happiness	0.1	0.1	0.1	-0.3	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.1	-0.3	-0.4
Hair/balding pattern: Pattern 4	0.1	0.4	0.6	0.8	0.4
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.3	-0.5	0.2
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	0.2	0.5
High blood pressure (siblings)	0.1	0.2	0.4	0.0	-0.6
Exposure to tobacco smoke outside home	0.1	0.2	0.3	0.2	0.5
Comparative body size at age 10	0.1	0.2	0.3	-0.2	-0.6
Worry too long after embarrassment	0.1	0.2	0.3	-0.3	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.1	-0.0	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.3	0.2	0.6
Medication: Omeprazole	0.1	0.1	0.1	0.0	0.4
Friendships satisfaction	0.1	0.1	0.3	0.1	0.5
Osteoporosis (self-reported)	0.1	0.1	0.1	-0.2	0.3
Osteoarthritis (self-reported)	0.1	0.1	0.1	-0.3	0.3
Ever smoked	0.1	0.2	0.5	-0.1	0.7
Risk taking	0.1	0.1	0.2	0.2	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.3	0.1	-0.6
Neuroticism (Nagel 2018)	0.0	0.1	0.1	0.3	-0.2
Irritable Bowel Disease (IBD)	0.0	0.1	0.1	-0.1	0.3
Ulcerative Colitis (UC)	0.0	0.1	0.1	-0.4	0.2
Ovarian Cancer	0.0	0.1	0.1	0.1	0.3
Age at First Birth	0.0	0.0	0.1	-0.1	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.0	0.2	-0.0
Primary Biliary Cirrhosis	0.0	0.0	0.1	-0.2	-0.2
Lung FEV1/FVC ratio	0.0	0.1	0.2	-0.3	0.4
Hair Pigment	0.0	0.4	0.7	0.9	0.0
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.1	-0.2	0.1
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	-0.0	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.1	0.1	-0.3
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.0	0.0	-0.2
Medication: Ramipril	0.0	0.1	0.1	0.3	0.0
Depression (self-reported)	0.0	0.1	0.1	0.3	-0.2
Illnesses of mother	0.0	0.0	0.0	0.0	-0.1
Exposure to tobacco smoke at home	0.0	0.0	0.0	-0.1	0.1
Birth weight	0.0	0.1	0.1	-0.1	0.3
Medication: Seretide 50 evohaler	0.0	0.0	0.1	0.3	-0.1
Mean time to correctly identify matches	0.0	0.0	0.0	0.1	-0.0
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.1	-0.0	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	0.2	0.0
Breast cancer (self-reported)	0.0	0.0	0.0	-0.1	-0.1
Medication: Gliclazide	0.0	0.0	0.1	-0.1	0.3
Financial situation satisfaction	0.0	0.0	0.1	-0.0	-0.3

Hub : Genes

EIF3I

Models

Trait associations