Hub : Genes

SPOCD1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0406	0.0126	2.9e-06	0.037	0.020	0.036	0.034	0.037	2.5e-12	3.1e-07	4.7e-12	2.7e-11	2.5e-12
2	TCGA	Brain Lower Grade Glioma	0.0479	0.0215	1.8e-04	0.045	0.041	0.041	NA	0.040	6.5e-06	1.9e-05	1.7e-05	NA	2.0e-05
3	TCGA	Thyroid Carcinoma	0.0440	0.0240	3.1e-03	0.019	0.022	0.021	NA	0.021	5.2e-03	3.0e-03	3.3e-03	NA	3.5e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.4	0.6	0.8	-0.7	-0.5
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	0.4	-0.4	-0.2
Depressed Affect (Nagel 2018)	0.1	0.2	0.6	-0.3	-0.1	-0.8
Depression (Nagel 2018)	0.3	0.5	1.4	0.1	-0.3	-1.2
Intelligence (Savage-Jansen 2018)	0.9	2.7	3.1	-1.7	1.4	1.8
Neuroticism (Nagel 2018)	0.5	1.2	2.5	0.6	-0.8	-1.6
Schizophrenia (2018)	0.0	0.0	0.0	-0.1	0.0	0.1
Schizophrenia vs Biploar Disorder	0.7	1.0	1.6	-0.9	0.7	1.3
Worry (Nagel 2018)	1.8	3.8	5.3	1.7	-1.8	-2.3
Alzheimer’s Disease (in mother)	0.6	0.7	1.0	0.8	-0.7	-1.0
Alzheimer’s Disease (in father)	0.4	0.5	1.1	-0.5	0.3	1.1
Alzheimer’s Disease (including proxy)	1.0	1.5	1.8	1.4	-1.3	-1.0
Crohns Disease (2017)	0.7	1.5	2.0	1.2	-1.1	-1.4
Irritable Bowel Disease (IBD)	0.0	0.1	0.3	0.0	0.1	-0.5
Ulcerative Colitis (UC)	0.6	1.1	1.5	-1.2	1.2	0.5
Major Depression (MDD)	0.2	0.3	0.4	0.6	-0.6	-0.5
Reaction Time	0.3	0.6	1.1	0.8	-1.0	-0.0
Verbal and Numeric Reasoning (VNR)	1.5	3.5	4.0	-2.0	2.0	1.6
Breast Cancer	0.1	0.1	0.4	0.6	0.1	0.1
Ovarian Cancer	1.0	1.4	1.8	-1.3	1.1	1.1
Prostate Cancer	2.6	3.6	5.4	-1.9	1.4	2.3
Age at First Birth	1.3	1.9	2.3	-1.4	1.3	1.5
Bipolar Disorder (2011)	0.1	0.1	0.4	0.6	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.4	0.2	0.4
Coronary Artery Disease (CAD)	0.4	0.5	1.6	1.2	0.0	0.0
Crohns Disease (2012)	1.4	2.2	3.3	1.5	-1.0	-1.8
Mean Putamen Volume	0.6	0.7	1.2	0.8	-0.6	-1.1
Fasting Glucose	2.1	2.5	3.0	1.7	-1.6	-1.5
HbA1C	1.3	1.4	2.2	-1.5	0.9	1.1
HDL Cholesterol	0.1	0.2	0.3	-0.5	0.6	-0.1
LDL Cholesterol	1.0	1.5	2.0	1.2	-1.4	-1.0
Lupus	2.2	3.3	4.8	-2.0	2.2	1.1
Neuroticism (2016)	0.1	0.2	0.2	-0.5	0.4	-0.4
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.3	-0.4	0.1
Rheumatoid Arthritis	0.5	0.7	0.8	-0.7	0.8	0.9
Schizophrenia (2014)	0.1	0.2	0.4	-0.3	0.3	0.7
Triglycerides	0.6	1.0	1.3	1.0	-1.1	-0.8
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	-0.1	0.2	0.6
Ulcerative Colitis	0.2	0.3	0.5	-0.7	0.7	0.0
Blood Eosinophil Count	0.7	5.6	6.8	-2.6	2.5	2.0
Blood Platelet Count	0.0	0.2	0.4	-0.6	0.6	0.1
Blood Red Count	0.1	1.1	1.9	-1.2	1.4	0.2
Blood White Count	0.2	1.8	2.8	1.2	-1.1	-1.7
Heel T-Score	0.2	1.8	3.4	-1.4	1.9	0.0
BMI	0.0	0.1	0.2	0.1	0.4	-0.2
Height	1.3	25.6	34.8	-4.4	4.7	5.9
Waist Hip Ratio (WHR)	0.1	0.2	0.6	-0.4	0.2	0.8
Systolic Blood Pressure	2.1	10.4	10.9	3.2	-3.3	-3.2
Smoking Status	1.9	4.6	6.0	2.1	-2.5	-1.9
Allergy or Eczema	0.7	1.7	2.4	1.6	-1.4	-0.9
Cardiovascular Disease	0.2	0.6	0.8	0.8	-0.7	-0.9
Hypothyroidism (self reported)	0.3	0.6	1.0	0.8	-0.5	-1.0
Respiratory disease	1.7	3.7	4.7	2.2	-1.9	-1.7
Type 2 Diabetes (T2D) (2018)	1.3	2.5	3.6	1.7	-1.0	-1.9
Lung FEV1/FVC ratio	0.1	0.6	1.0	1.0	-0.8	-0.4
Lung FVC	0.2	0.9	1.1	-0.9	0.9	1.0
Neuroticism	2.0	4.9	6.9	2.0	-1.9	-2.6
Chronotype (morning person)	0.2	0.5	0.8	-0.9	0.8	0.4
Hair Pigment	0.0	0.1	0.2	-0.4	-0.3	0.1
Tanning	0.0	0.4	0.5	0.7	-0.4	-0.6
Hand grip strength (left)	2.0	5.3	8.6	-1.8	2.0	2.9
Number of treatments/medications taken	1.8	3.3	3.6	1.6	-1.9	-1.9
Average weekly spirits intake	0.0	0.0	0.0	0.0	-0.2	0.0
Sensitivity / hurt feelings	0.6	1.1	1.6	0.9	-0.9	-1.3
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	-0.0	-0.4	-0.5
Hearing difficulty/problems: Yes	0.9	1.4	2.2	1.0	-1.5	-0.9
Relative age of first facial hair	0.9	1.9	2.6	1.4	-1.1	-1.6
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	1.5	1.2	-1.1	-1.2
Ever used hormone-replacement therapy (HRT)	3.8	4.8	5.6	-2.3	2.4	1.8
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	-0.4	0.3	0.4
Systolic blood pressure, automated reading	1.3	3.8	5.0	1.8	-1.8	-2.2
Eye problems/disorders: Diabetes related eye disease	3.1	3.4	5.1	2.3	-1.6	-1.6
Angina	3.1	4.1	4.7	2.2	-1.7	-2.2
Medication for hormone replacement therapy	0.0	0.0	0.1	-0.1	0.0	0.3
Vitamin and mineral supplements	0.2	0.3	0.5	0.3	-0.7	-0.6
Supplements: Zinc	0.1	0.1	0.2	0.1	-0.1	0.4
Medication: Co-codamol	0.0	0.0	0.1	-0.1	-0.0	0.4
Medication: Metformin	0.9	1.2	1.5	1.2	-0.9	-1.2
Diabetes (father)	1.6	2.0	2.4	1.4	-1.5	-1.3
Diabetes (mother)	2.2	2.8	3.3	1.7	-1.8	-1.5
Severe depression (siblings)	0.9	1.0	1.6	0.8	-0.7	-1.3
Pack years adult smoking proportion	3.0	4.5	6.1	2.0	-1.9	-2.5
Impedance of leg (right)	0.8	3.9	4.4	1.7	-2.1	-2.1
Leg fat-free mass (left)	0.8	4.3	5.7	-1.8	2.0	2.4
Trunk fat percentage	0.1	0.2	0.6	0.2	-0.2	-0.8
Hand grip strength (right)	1.4	3.8	7.0	-1.4	1.5	2.6
Townsend deprivation index at recruitment	3.8	5.3	7.5	2.1	-2.0	-2.7
Current tobacco smoking	3.9	6.4	8.0	2.5	-2.8	-2.2
Average weekly fortified wine intake	0.1	0.1	0.2	0.3	-0.5	0.3
Maternal smoking around birth	3.8	5.5	7.0	2.2	-2.2	-2.6
Fed-up feelings	0.6	1.1	1.8	0.7	-1.0	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	3.3	1.1	-1.3	-1.8
Relative age voice broke	0.3	0.5	0.7	0.7	-0.5	-0.9
Taking other prescription medications	1.2	1.9	2.0	1.3	-1.4	-1.4
Age when periods started (menarche)	0.1	0.3	0.3	-0.4	0.6	0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.1	-0.3	0.1	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.1	0.3	0.1	-0.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	0.7	-0.4	-0.3
Qualifications: CSEs or equivalent	11.7	15.5	16.1	4.0	-3.8	-4.0
Serious illness, injury or assault to yourself	0.0	0.0	0.1	0.3	-0.1	-0.3
High blood pressure	0.1	0.2	0.3	0.6	-0.3	-0.5
Hayfever, allergic rhinitis or eczema	0.8	1.6	2.3	1.3	-1.5	-0.9
Multivitamins +/- minerals	0.9	1.2	1.8	-0.9	1.3	0.9
Stomach or abdominal pain in last month	1.6	2.0	2.5	1.4	-1.2	-1.6
Supplements: Glucosamine	0.2	0.3	0.5	-0.3	0.5	0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	-0.4	0.7	0.1
Medication: Atenolol	0.2	0.2	0.4	-0.1	0.7	-0.4
Medication: Levothyroxine sodium	0.5	0.9	1.3	-1.1	1.1	0.5
Sitting height	0.8	5.6	8.2	-2.0	2.1	2.9
Chronic bronchitis/emphysema (father)	6.8	8.0	9.2	3.0	-3.0	-2.4
High blood pressure (mother)	0.6	0.8	1.5	-0.9	1.2	0.1
Body mass index (BMI)	0.1	0.2	0.7	0.2	0.2	-0.8
Impedance of leg (left)	0.7	3.6	4.0	1.7	-2.0	-2.0
Leg predicted mass (left)	0.8	4.3	5.6	-1.8	2.0	2.4
Trunk fat mass	0.0	0.2	0.3	-0.5	0.6	0.2
Waist circumference	0.0	0.1	0.2	-0.1	0.5	0.1
Number of incorrect matches in round	0.6	0.9	1.1	1.0	-1.0	-0.9
Past tobacco smoking	0.4	0.7	1.0	-0.7	1.0	0.7
Alcohol usually taken with meals	8.9	14.4	15.5	-3.6	3.9	3.9
Nervous feelings	0.2	0.4	0.8	0.4	-0.4	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.5	0.7	-1.2	-1.0
Hearing difficulty/problems with background noise	0.2	0.3	0.3	0.5	-0.6	-0.5
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	-0.3	0.5	0.9
Had menopause	1.6	2.0	2.9	-1.2	1.2	1.7
Had other major operations	0.2	0.3	0.5	0.6	-0.1	-0.7
Forced vital capacity (FVC)	0.7	2.6	4.3	-1.4	1.2	2.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	0.5	-0.2	-0.6
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.2	-1.1	1.0	1.1
Qualifications: None of the above	1.0	2.2	3.6	1.2	-1.4	-1.9
Financial difficulties in last 2 years	1.8	2.4	2.9	1.6	-1.7	-1.4
Mouth/teeth dental problems	0.1	0.1	0.2	-0.3	0.5	0.1
Heart attack	0.1	0.1	0.3	-0.0	0.4	-0.6
Allergy	0.4	0.9	1.2	-1.1	1.0	0.8
Pain all over the body in last month	0.0	0.0	0.0	-0.1	0.0	0.2
Diabetes (self-reported)	1.9	2.9	4.2	1.7	-1.3	-2.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.6	0.8	-0.7	-0.6
Medication: Ramipril	0.0	0.0	0.1	0.2	-0.2	0.3
Medication: Simvastatin	1.6	2.3	3.5	1.4	-1.2	-1.9
Fluid intelligence score	2.4	5.0	5.5	-2.3	2.3	2.0
Illnesses of siblings	0.0	0.0	0.1	-0.1	0.2	0.3
Neuroticism score	2.0	4.1	5.6	1.9	-1.8	-2.4
Weight	0.4	1.9	2.5	-1.2	1.6	1.3
Impedance of arm (right)	0.2	1.2	1.6	0.9	-1.3	-1.0
Arm fat percentage (right)	0.1	0.5	1.2	0.4	-0.2	-1.1
Trunk fat-free mass	1.3	7.3	9.2	-2.3	2.7	3.0
Hip circumference	0.0	0.0	0.1	0.2	0.2	-0.2
Time employed in main current job	0.1	0.1	0.2	-0.2	-0.3	0.4
Alcohol intake versus 10 years previously	1.6	2.4	4.6	0.8	-1.4	-2.1
Father’s age at death	1.3	1.8	2.6	-1.3	1.6	1.0
Worrier / anxious feelings	0.5	0.9	1.5	0.8	-0.7	-1.2
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	3.0	1.6	-1.4	-1.7
Falls in the last year	0.1	0.2	0.3	-0.4	0.6	0.3
Hair/balding pattern: Pattern 3	2.2	3.3	4.0	1.8	-1.7	-2.0
Number of live births	0.7	1.0	1.4	1.2	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	1.8	-0.9	0.8	1.3
Pulse rate	0.5	0.8	1.5	0.8	-1.2	-0.4
Happiness	0.1	0.1	0.2	0.4	-0.2	0.0
Noisy workplace	1.3	1.6	2.4	1.0	-1.2	-1.6
Qualifications: A levels/AS levels or equivalent	6.1	13.5	14.7	-3.5	3.8	3.6
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	-0.1	0.4	0.1
Mouth/teeth dental problems: Dentures	0.7	1.2	1.4	1.0	-1.0	-1.2
Asthma	0.0	0.1	0.1	-0.2	0.3	0.3
Medication: Ibuprofen (e.g. Nurofen)	2.3	2.9	3.6	1.8	-1.9	-1.3
Medication: Cholesterol lowering	1.4	2.2	2.5	1.6	-1.3	-1.5
Depression (self-reported)	1.0	1.2	1.7	0.7	-1.2	-1.3
Medication: Lansoprazole	0.3	0.4	0.5	-0.7	0.7	0.4
Prospective memory result	0.1	0.1	0.2	0.4	-0.3	-0.5
Lung cancer (father)	0.1	0.1	0.2	0.4	-0.3	-0.1
Illnesses of mother	1.0	1.3	1.9	1.3	-1.4	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.3	-0.9	0.9	1.2
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	-0.2	0.0	-0.4
Impedance of arm (left)	0.3	1.3	1.9	1.0	-1.4	-1.0
Arm fat mass (right)	0.0	0.1	0.2	-0.0	0.3	-0.4
Trunk predicted mass	1.2	7.1	9.0	-2.3	2.6	3.0
Standing height	1.3	13.3	20.0	-3.2	3.1	4.5
Length of working week for main job	1.6	1.8	2.2	1.1	-1.5	-1.4
Exposure to tobacco smoke at home	0.3	0.3	0.6	0.3	-0.8	-0.5
Breastfed as a baby	2.7	3.4	4.1	-1.5	2.0	2.0
Tense / ‘highly strung’	0.3	0.5	0.9	0.5	-0.9	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	1.9	0.7	-1.1	-1.4
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	-0.0	-0.2	-0.5
Birth weight of first child	0.4	0.8	1.3	-1.1	0.9	0.4
Peak expiratory flow (PEF)	0.0	0.1	0.1	0.2	-0.4	0.1
Pulse wave reflection index	0.2	0.2	0.5	0.3	-0.2	-0.7
Ever highly irritable/argumentative for 2 days	0.5	0.6	0.8	0.9	-0.9	-0.5
Loud music exposure frequency	1.5	1.7	2.5	1.6	-1.4	-0.8
Qualifications: O levels/GCSEs or equivalent	3.8	6.1	7.5	-2.3	2.7	2.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.7	0.6	-0.8	-0.2
Blood clot in the leg (DVT)	0.4	0.5	0.6	-0.7	0.7	0.6
Medication: Paracetamol	2.5	4.1	7.2	1.6	-1.6	-2.7
Headache pain in last month	0.5	0.8	1.7	0.4	-0.7	-1.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.4	-0.6	0.4	0.5
Glaucoma (self-reported)	0.6	0.7	0.7	-0.8	0.8	0.8
Gout (self-reported)	0.8	1.1	1.3	1.1	-1.1	-0.9
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.1	-0.1	0.3	-0.3
Medication: Amlodipine	0.3	0.4	0.5	-0.6	0.7	0.7
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	0.2	0.0	-0.5
Birth weight	2.7	5.8	6.1	-2.5	2.5	2.3
Chronic bronchitis/emphysema (mother)	3.0	3.5	4.3	1.8	-1.7	-2.1
High blood pressure (siblings)	0.4	0.6	1.2	0.5	-0.7	-1.1
Forced vital capacity (FVC), Best measure	0.7	2.6	3.1	-1.5	1.5	1.8
Body fat percentage	0.1	0.5	1.3	0.4	-0.4	-1.1
Leg fat percentage (right)	0.3	1.0	2.2	0.7	-0.6	-1.5
Arm fat-free mass (right)	1.1	5.7	7.0	-2.1	2.4	2.6
Exposure to tobacco smoke outside home	3.4	4.5	6.7	2.0	-1.7	-2.6
Comparative body size at age 10	0.1	0.2	0.3	0.4	-0.5	-0.1
Number of full brothers	1.3	1.6	2.2	1.2	-1.5	-1.0
Worry too long after embarrassment	0.7	1.2	1.4	1.1	-1.0	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.7	-0.8	0.7	0.5
Wheeze or whistling in the chest in last year	0.1	0.2	0.2	0.4	-0.5	-0.4
Number of children fathered	0.0	0.0	0.0	-0.1	-0.1	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.3	-0.5	0.6	0.2
Age at first live birth	2.7	4.8	7.9	-2.1	1.5	2.8
Pulse wave peak to peak time	0.1	0.1	0.4	0.1	0.0	0.6
Health satisfaction	0.1	0.2	0.5	0.2	-0.2	-0.7
Shortness of breath walking on level ground	0.2	0.2	0.5	0.4	-0.1	-0.7
Qualifications: College or University degree	3.6	11.3	18.1	-3.1	2.5	4.2
Eye problems/disorders: None of the above	0.3	0.4	0.8	-0.9	0.6	0.2
Mouth/teeth dental problems: Loose teeth	0.0	0.1	0.1	-0.3	0.1	-0.3
Emphysema/chronic bronchitis	0.7	0.8	0.9	1.0	-0.7	-1.0
Medication for pain relief, constipation, heartburn	0.3	0.5	1.4	-0.4	0.1	1.2
Neck or shoulder pain in last month	2.1	3.0	5.6	1.5	-1.1	-2.4
Medication: Blood pressure	0.0	0.0	0.1	-0.1	0.2	0.3
Angina (self-reported)	3.4	4.5	5.3	2.3	-1.8	-2.3
Migraine (self-reported)	0.2	0.2	0.4	-0.4	0.7	0.0
Medication: Ibuprofen	2.6	3.1	3.8	1.9	-1.9	-1.4
Medication: Allopurinol	0.3	0.5	0.7	-0.7	0.5	0.8
Medication: Omeprazole	0.2	0.3	0.7	0.1	-0.3	-0.8
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.5	0.4	0.5
Mean time to correctly identify matches	0.1	0.1	0.2	0.2	-0.4	0.4
Heart disease (mother)	0.6	0.8	1.2	-0.7	0.8	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.5	-0.7	0.4	0.6
Whole body fat mass	0.0	0.1	0.2	-0.2	0.4	-0.3
Leg fat mass (right)	0.0	0.1	0.4	0.1	0.0	-0.6
Arm predicted mass (right)	0.9	4.8	6.5	-1.9	2.1	2.5
Pulse rate, automated reading	0.2	0.5	1.0	0.6	-1.0	0.4
Alcohol intake frequency.	3.1	7.2	12.1	2.5	-1.8	-3.5
Comparative height size at age 10	3.9	21.7	26.7	-4.6	4.1	5.2
Number of full sisters	0.8	1.0	1.3	1.1	-0.7	-1.1
Suffer from ‘nerves’	0.2	0.3	0.6	0.4	-0.4	-0.8
Overall health rating	3.4	7.3	9.1	2.6	-2.5	-3.0
Chest pain or discomfort	0.1	0.2	0.2	0.5	-0.5	-0.3
Had major operations	0.8	1.0	1.4	-0.8	1.2	0.9
Age at last live birth	0.3	0.4	1.0	-0.4	0.4	1.0
Family relationship satisfaction	0.9	1.1	1.4	-1.0	1.2	1.0
Leg pain on walking	4.2	5.3	6.8	2.3	-2.6	-1.9
Qualifications: NVQ or HND or HNC or equivalent	5.4	6.5	8.0	2.6	-2.2	-2.8
Commuting to job workplace: Car/motor vehicle	1.8	2.0	3.3	1.4	-1.0	-1.8
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.4	-0.2	0.0	0.6
Medication: Aspirin	2.0	2.6	3.1	-1.4	1.6	1.8
Supplements: Vitamin C	0.2	0.2	0.4	0.7	-0.4	0.0
Knee pain experienced in last month	1.7	2.7	3.0	1.7	-1.6	-1.5
Hypertension (Self-reported)	0.0	0.0	0.1	0.3	-0.1	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.7	0.1	0.2	-0.8
Illnesses of father: Heart disease	0.0	0.1	0.1	0.2	-0.2	-0.3
Illnesses of siblings: Diabetes	0.0	0.1	0.1	0.1	-0.3	0.2
Smoking status: Previous	0.1	0.1	0.2	0.2	-0.5	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.2	1.1	-0.8	-0.2
Whole body fat-free mass	1.2	6.7	8.4	-2.2	2.6	2.9
Leg fat-free mass (right)	0.9	5.0	6.7	-1.9	2.2	2.6
Arm fat percentage (left)	0.2	0.8	1.7	0.6	-0.5	-1.3
Average weekly red wine intake	8.0	11.8	14.4	-3.3	3.8	3.2
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.0	-0.1	0.2	0.0
Mood swings	0.2	0.4	0.5	0.5	-0.7	-0.6
Loneliness, isolation	0.0	0.0	0.1	-0.1	-0.1	-0.2
Long-standing illness, disability or infirmity	3.8	5.8	6.7	2.4	-2.2	-2.6
Ever had bowel cancer screening	1.3	1.5	1.8	-1.3	1.0	1.4
Diabetes diagnosed by doctor	3.2	5.3	7.2	2.3	-1.9	-2.7
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.1	-0.2	0.4
Friendships satisfaction	0.2	0.3	0.6	0.3	0.3	-0.8
Qualifications: nursing, teaching	3.5	5.4	8.2	-2.1	1.8	2.9
Commuting to job workplace: Walk	0.0	0.0	0.0	0.1	-0.1	0.2
Eye problems/disorders: Cataract	0.1	0.1	0.4	0.2	-0.0	0.6
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.3	-0.7	0.3	1.5
Medication for cholesterol	0.1	0.1	0.1	0.3	-0.4	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	2.0	1.2	-1.3	-1.4
Back pain experienced in last month	1.3	1.8	2.0	1.4	-1.3	-1.3
Mineral and other dietary supplements	0.1	0.1	0.1	-0.0	-0.3	-0.4
Breast cancer (self-reported)	0.1	0.1	0.3	-0.3	0.1	-0.6
Asthma (self-reported)	0.0	0.0	0.0	0.0	0.1	0.1
Osteoporosis (self-reported)	0.2	0.3	0.5	0.3	-0.4	-0.7
Osteoarthritis (self-reported)	4.4	5.7	8.5	2.0	-2.2	-2.9
Medication: Aspirin	3.2	4.1	4.7	-1.9	2.0	2.2
Medication: Gliclazide	0.4	0.5	0.7	-0.8	0.8	0.2
Illnesses of father: None of the above (group 1)	1.4	1.7	1.8	-1.3	1.3	1.3
Smoking status: Current	2.2	3.5	4.3	1.8	-2.1	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.1	0.1	-0.2	0.1
Whole body water mass	1.3	7.4	9.2	-2.4	2.7	3.0
Leg predicted mass (right)	1.0	5.1	6.6	-1.9	2.2	2.6
Arm fat mass (left)	0.0	0.1	0.1	-0.1	0.4	-0.3
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	0.4	-0.3	-0.7
Average weekly champagne plus white wine intake	0.2	0.3	0.4	0.4	-0.6	-0.6
Miserableness	1.6	2.8	3.3	1.6	-1.7	-1.8
Guilty feelings	3.7	5.6	6.8	2.2	-2.2	-2.6
Wears glasses or contact lenses	0.1	0.2	0.2	-0.3	0.5	0.4
Ever taken oral contraceptive pill	1.0	1.1	1.3	-1.1	0.9	1.1
Hearing aid user	3.9	4.4	5.2	2.3	-2.2	-1.8
Mother’s age at death	2.7	3.4	3.8	-1.9	1.8	1.8
Financial situation satisfaction	0.7	0.8	1.0	1.0	-1.0	-0.7
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.5	0.3	0.0
Commuting to job workplace: Public transport	1.2	1.5	2.7	1.3	-1.6	-0.1
Eye problems/disorders: Glaucoma	0.5	0.6	0.7	0.8	-0.7	-0.8
Medication: Blood pressure	0.0	0.0	0.0	0.0	0.2	-0.1
Pain type(s) experienced in last month: Hip pain	3.2	4.0	5.2	2.3	-1.9	-1.8
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.8	-0.2	0.1	0.9
High cholesterol (Self-reported)	0.6	1.0	1.4	1.2	-1.0	-0.7
Medication: Bendroflumethiazide	0.1	0.1	0.1	-0.1	-0.3	-0.4
Medication: Paracetamol	3.5	5.5	7.6	2.0	-2.1	-2.8
Medication: Lisinopril	1.0	1.2	1.7	1.2	-0.8	-1.3
Medication: Atorvastatin	0.1	0.1	0.3	0.4	-0.5	-0.2
Illnesses of father: High blood pressure	0.6	0.7	1.3	-0.8	1.1	0.4
Alcohol drinker status: Never	0.2	0.2	0.3	0.6	-0.3	0.3
Ever smoked	0.8	1.4	1.7	1.1	-1.3	-1.1
Basal metabolic rate	0.9	5.0	6.1	-2.0	2.3	2.5
Leg fat percentage (left)	0.2	0.6	1.6	0.5	-0.3	-1.3
Arm fat-free mass (left)	1.1	5.8	6.6	-2.2	2.4	2.6
Number of operations (self-reported)	0.1	0.1	0.1	-0.0	0.4	-0.4
Average weekly beer plus cider intake	1.0	1.4	1.5	1.2	-1.2	-1.2
Irritability	0.1	0.2	0.3	-0.6	0.5	0.4
Risk taking	0.9	1.4	2.5	-1.0	0.8	1.6
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.0	-0.2	0.2	0.1
Fractured/broken bones in last 5 years	0.4	0.5	0.6	0.7	-0.8	-0.6
Age started oral contraceptive pill	3.3	4.1	4.3	-2.1	2.0	2.0
Diastolic blood pressure, automated reading	1.3	4.0	5.1	1.8	-1.9	-2.3
Ever depressed for a whole week	0.6	0.8	1.9	-0.6	0.2	1.4
Unable to work because of sickness or disability	4.2	5.5	10.6	2.0	-1.4	-3.3
Commuting to job workplace: Cycle	0.2	0.3	0.6	0.4	0.1	-0.8
Myopia	0.2	0.3	0.6	-0.8	0.7	0.1
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.3	-0.2	-0.1	0.6
Cholesterol lowering medication	0.1	0.1	0.2	-0.3	0.3	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.8	0.4	-0.4	-0.9
Pain experienced in last month	1.9	3.2	4.8	-1.7	1.4	2.2
Supplements: Calcium	0.2	0.2	0.5	0.7	-0.5	-0.0
Basal cell carcinoma (self-reported)	2.0	2.4	2.8	-1.6	1.7	1.4
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	-0.1	0.4	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.4	-0.6	0.5	0.6
Heart disease (siblings)	1.2	1.4	2.1	-1.0	1.1	1.4
Alcohol drinker status: Previous	0.8	0.9	1.7	0.9	-0.4	-1.3
Pack years of smoking	1.9	2.8	4.0	1.6	-1.4	-2.0
Impedance of whole body	0.6	2.9	3.6	1.5	-1.9	-1.7
Leg fat mass (left)	0.0	0.1	0.3	0.1	0.2	-0.5
Arm predicted mass (left)	1.0	5.1	6.0	-2.0	2.3	2.4