Best TWAS P=1.45e-24 · Best GWAS P=6.94e-49 conditioned to 3.66e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FNDC3B | 0.07 | 0.06 | enet | 8 | 0.05 | 3.2e-07 | -10.9 | 9.8 | 1.3e-22 | 0.06 | 0.97 | 0.00 | TRUE |
| 2 | GTEx | Artery Coronary | NCEH1 | 0.22 | 0.00 | lasso | 4 | -0.01 | 7.0e-01 | 6.5 | 5.9 | 4.0e-09 | 0.32 | 0.06 | 0.30 | TRUE |
| 3 | GTEx | Breast Mammary Tissue (Female) | PLD1 | 0.07 | -0.01 | lasso | 1 | 0.01 | 2.2e-01 | 5.8 | 5.8 | 8.5e-09 | -0.01 | 0.05 | 0.07 | FALSE |
| 4 | GTEx | Ovary | TNFSF10 | 0.40 | 0.01 | lasso | 10 | 0.05 | 1.8e-02 | 3.1 | 9.6 | 5.4e-22 | 0.24 | 0.05 | 0.26 | TRUE |
| 5 | YFS | Blood | TNFSF10 | 0.09 | 0.04 | bslmm | 462 | 0.08 | 1.6e-24 | 8.7 | 7.5 | 6.9e-14 | 0.25 | 1.00 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Glioblastoma Multiforme | FNDC3B | 0.27 | 0.05 | lasso | 6 | 0.08 | 1.8e-03 | 4.9 | -8.5 | 2.5e-17 | -0.61 | 0.06 | 0.30 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FNDC3B | 0.07 | 0.02 | enet | 6 | 0.02 | 3.9e-03 | 10.7 | -10.2 | 1.4e-24 | -0.71 | 0.08 | 0.83 | TRUE |
| 8 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TNFSF10 | 0.17 | 0.11 | lasso | 2 | 0.09 | 6.0e-04 | -6.4 | 6.4 | 1.2e-10 | 0.40 | 0.04 | 0.10 | FALSE |